SIMILAR PATTERNS OF AMINO ACIDS FOR 5XU8_A_DX4A701_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		4 GLY A  13
ASN A  26
ALA A 361
PHE A  24
 None
 0.81A 5xu8A-1a0dA:
undetectable		 5xu8A-1a0dA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 ASN 1 134
SER 1 132
GLN 1 133
ALA 1 230
 None
 0.80A 5xu8A-1ev11:
undetectable		 5xu8A-1ev11:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		4 LEU A 218
ASN A 264
SER A 265
ALA A 104
 None
 0.76A 5xu8A-1f2pA:
undetectable		 5xu8A-1f2pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 GLY A 611
ASN A 616
ALA A 596
PHE A 614
 None
 0.98A 5xu8A-1gxlA:
undetectable		 5xu8A-1gxlA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 134
LEU A 135
ASN A  57
SER A  58
 None
 0.87A 5xu8A-1qlbA:
undetectable		 5xu8A-1qlbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 6

(Saccharomyces
cerevisiae) 		PF00443
(UCH) 		5 GLY A 110
ASN A 121
GLN A 125
ALA A 450
PHE A 464
 None
 0.47A 5xu8A-1vjvA:
30.3		 5xu8A-1vjvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdf E2 GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2) 		4 ASN A 979
SER A 975
ALA A 974
PHE A 977
 None
 0.94A 5xu8A-1wdfA:
undetectable		 5xu8A-1wdfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		4 GLY A  71
LEU A  72
GLN A 280
ALA A 283
 None
 0.90A 5xu8A-1xi9A:
undetectable		 5xu8A-1xi9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		4 GLY A 241
ASN A 237
SER A 234
PHE A 238
 None
 0.77A 5xu8A-1xnfA:
undetectable		 5xu8A-1xnfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 LEU A  36
CYH A  33
GLN A  40
ALA A  43
 None
 0.99A 5xu8A-2axqA:
undetectable		 5xu8A-2axqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A 105
LEU A 106
ASN A 116
PHE A 449
 None
 0.43A 5xu8A-2aynA:
30.3		 5xu8A-2aynA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A 105
LEU A 106
GLN A 120
PHE A 449
 None
 0.70A 5xu8A-2aynA:
30.3		 5xu8A-2aynA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE

(Thermus
thermophilus) 		PF05067
(Mn_catalase) 		4 GLY A 179
LEU A 182
ASN A 215
SER A 216
 None
 0.88A 5xu8A-2cwlA:
undetectable		 5xu8A-2cwlA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 GLY A 686
ASN A 458
GLN A 462
PHE A 553
 None
 0.77A 5xu8A-2dfsA:
undetectable		 5xu8A-2dfsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		5 GLY A 215
LEU A 216
ASN A 226
GLN A 230
PHE A 480
 None
 0.59A 5xu8A-2f1zA:
27.4		 5xu8A-2f1zA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		4 GLY A 215
SER A 227
GLN A 230
PHE A 480
 None
 0.64A 5xu8A-2f1zA:
27.4		 5xu8A-2f1zA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 GLY A 157
LEU A 122
CYH A 120
ALA A  28
 None
 0.98A 5xu8A-2i2xA:
undetectable		 5xu8A-2i2xA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 124
LEU A 125
GLN A 137
ALA A 282
 None
HEM  A 505 (-4.1A)
None
None
 0.86A 5xu8A-2q9gA:
undetectable		 5xu8A-2q9gA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		4 GLY A  44
LEU A  43
SER A  17
ALA A  39
 None
 0.96A 5xu8A-2vc2A:
undetectable		 5xu8A-2vc2A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		7 GLY A 303
LEU A 304
ASN A 314
SER A 315
GLN A 318
ALA A 884
PHE A 897
 None
None
CME  A 311 ( 4.7A)
CME  A 311 ( 4.7A)
None
None
None
 0.27A 5xu8A-2y6eA:
40.5		 5xu8A-2y6eA:
41.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 GLY A 155
ASN A 151
SER A 148
PHE A 152
 None
 0.77A 5xu8A-3bqyA:
undetectable		 5xu8A-3bqyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 GLY A 283
LEU A 244
CYH A 246
ALA A 290
 None
 0.76A 5xu8A-3c87A:
undetectable		 5xu8A-3c87A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 GLY A 271
ASN A  60
SER A  58
ALA A 447
 None
 0.96A 5xu8A-3ehmA:
undetectable		 5xu8A-3ehmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		4 GLY A 286
LEU A 220
SER A  12
ALA A  10
 None
 0.99A 5xu8A-3emyA:
undetectable		 5xu8A-3emyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezu GGDEF DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF00990
(GGDEF) 		4 GLY A 107
LEU A 110
SER A  21
ALA A  44
 None
 0.87A 5xu8A-3ezuA:
undetectable		 5xu8A-3ezuA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 GLY A 314
SER A 272
GLN A 267
ALA A 231
 None
 0.97A 5xu8A-3hgoA:
undetectable		 5xu8A-3hgoA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		5 GLY A 213
LEU A 214
ASN A 224
GLN A 228
ALA A 521
 None
 0.27A 5xu8A-3i3tA:
40.8		 5xu8A-3i3tA:
49.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 GLY E 140
GLN E 168
ALA E 171
PHE E 172
 None
 0.98A 5xu8A-3kfuE:
undetectable		 5xu8A-3kfuE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		4 GLY A 104
SER A  45
ALA A  63
PHE A  37
 None
 0.83A 5xu8A-3kxpA:
undetectable		 5xu8A-3kxpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 GLY A 849
ASN A 878
SER A 877
GLN A 879
 None
 0.93A 5xu8A-3lppA:
undetectable		 5xu8A-3lppA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		5 GLY A 138
LEU A 139
GLN A 153
ALA A 430
PHE A 442
 None
 0.19A 5xu8A-3m99A:
30.8		 5xu8A-3m99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		5 GLY A 138
LEU A 139
SER A 150
GLN A 153
PHE A 442
 None
 0.46A 5xu8A-3m99A:
30.8		 5xu8A-3m99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 GLY A 288
LEU A 249
CYH A 251
ALA A 295
 None
 0.81A 5xu8A-3mgaA:
undetectable		 5xu8A-3mgaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 253
LEU A 256
CYH A 334
SER A 332
 None
 0.95A 5xu8A-3mpiA:
undetectable		 5xu8A-3mpiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  35
SER A 108
ALA A 104
PHE A  53
 CL  A 238 (-3.5A)
None
None
CL  A 238 ( 4.8A)
 0.81A 5xu8A-3myxA:
undetectable		 5xu8A-3myxA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		7 GLY A 778
LEU A 779
ASN A 789
SER A 790
GLN A 793
ALA A1070
PHE A1083
 None
 0.34A 5xu8A-3n3kA:
41.2		 5xu8A-3n3kA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		7 GLY A 268
LEU A 269
ASN A 279
SER A 280
GLN A 283
ALA A 560
PHE A 573
 None
None
CME  A 276 ( 4.0A)
CME  A 276 ( 4.5A)
None
None
None
 0.10A 5xu8A-3nheA:
49.3		 5xu8A-3nheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no5 UNCHARACTERIZED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		4 GLY A 227
LEU A 246
GLN A 210
ALA A 214
 None
 0.86A 5xu8A-3no5A:
undetectable		 5xu8A-3no5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 393
LEU A 394
SER A 497
GLN A 498
 None
 0.90A 5xu8A-3pvcA:
undetectable		 5xu8A-3pvcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 GLY A 504
ASN A 508
ALA A 446
PHE A 506
 None
 0.84A 5xu8A-3q60A:
undetectable		 5xu8A-3q60A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		4 GLY A 199
LEU A 200
GLN A 258
PHE A 254
 NAP  A 268 (-4.7A)
None
None
None
 0.82A 5xu8A-3rkuA:
undetectable		 5xu8A-3rkuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 GLY A 187
LEU A 186
GLN A 217
ALA A 240
 None
None
UD1  A 366 (-3.6A)
None
 0.81A 5xu8A-3s2uA:
undetectable		 5xu8A-3s2uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 GLY A  94
LEU A 278
CYH A 372
SER A 394
 None
 0.76A 5xu8A-3t2nA:
undetectable		 5xu8A-3t2nA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 GLY A  66
LEU A  69
SER A  58
ALA A 125
 None
 0.93A 5xu8A-3vw5A:
undetectable		 5xu8A-3vw5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		6 GLY A 495
LEU A 496
ASN A 506
GLN A 510
ALA A 799
PHE A 819
 None
 0.32A 5xu8A-4czwA:
20.9		 5xu8A-4czwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		5 LEU A 496
SER A 507
GLN A 510
ALA A 799
PHE A 819
 None
 0.69A 5xu8A-4czwA:
20.9		 5xu8A-4czwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		4 GLY A  95
SER A  35
ALA A  54
PHE A  27
 None
 0.89A 5xu8A-4dgqA:
undetectable		 5xu8A-4dgqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fb5 PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 348
LEU A 349
ALA A 119
PHE A 345
 None
 0.91A 5xu8A-4fb5A:
undetectable		 5xu8A-4fb5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn4 SHORT CHAIN
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF13561
(adh_short_C2) 		4 GLY A 164
LEU A 165
SER A 145
ALA A 147
 None
None
NAD  A 501 (-3.6A)
None
 0.95A 5xu8A-4fn4A:
undetectable		 5xu8A-4fn4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 463
LEU A 464
GLN A 460
ALA A 457
 None
EDO  A 551 (-4.4A)
None
None
 0.99A 5xu8A-4hjhA:
undetectable		 5xu8A-4hjhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8j PUTATIVE EFFLUX
TRANSPORTER

(Bacteroides
eggerthii) 		PF16576
(HlyD_D23) 		4 GLY A  65
ASN A 173
ALA A  60
PHE A  61
 None
 0.89A 5xu8A-4l8jA:
undetectable		 5xu8A-4l8jA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 GLY E 153
LEU E 318
SER E 301
ALA E 162
 None
 0.78A 5xu8A-4obuE:
undetectable		 5xu8A-4obuE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe8 TAT-LINKED QUALITY
CONTROL PROTEIN TATD

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 GLY A   5
LEU A  33
CYH A  55
ALA A  45
 None
 0.78A 5xu8A-4pe8A:
undetectable		 5xu8A-4pe8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		5 GLY A 506
LEU A 507
ASN A 517
GLN A 521
PHE A 824
 None
 0.46A 5xu8A-4q8gA:
23.6		 5xu8A-4q8gA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		5 GLY A 506
LEU A 507
ASN A 517
GLN A 521
PHE A 824
 None
 0.41A 5xu8A-4q8hA:
21.9		 5xu8A-4q8hA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 188
SER A 143
ALA A 144
PHE A 145
 None
 0.81A 5xu8A-4tx1A:
undetectable		 5xu8A-4tx1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 GLY A  11
LEU A  13
SER A  54
PHE A  56
 None
 0.97A 5xu8A-4uw2A:
undetectable		 5xu8A-4uw2A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd3 L-AMINO ACID LIGASE

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		4 GLY A 155
LEU A 154
ASN A 110
ALA A 105
 None
 0.98A 5xu8A-4wd3A:
undetectable		 5xu8A-4wd3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		no annotation 5 GLY G 506
LEU G 507
ASN G 517
GLN G 521
PHE G 824
 None
 0.59A 5xu8A-4xr7G:
22.4		 5xu8A-4xr7G:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 GLY A 467
ASN A 294
GLN A 295
ALA A 462
 None
 0.91A 5xu8A-4xz8A:
undetectable		 5xu8A-4xz8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		4 GLY A 129
ASN A 157
SER A 156
ALA A 178
 None
 0.99A 5xu8A-4zpjA:
undetectable		 5xu8A-4zpjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		4 GLY A 585
LEU A 596
ALA A 619
PHE A 583
 None
 0.92A 5xu8A-4ztkA:
undetectable		 5xu8A-4ztkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		4 LEU A 114
CYH A  65
ALA A 121
PHE A 118
 None
 0.73A 5xu8A-4zu2A:
undetectable		 5xu8A-4zu2A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 GLY A  89
LEU A  92
ASN A 244
SER A 245
 None
 0.87A 5xu8A-4zyoA:
undetectable		 5xu8A-4zyoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 LEU A  92
ASN A 244
SER A 245
ALA A 249
 None
 0.98A 5xu8A-4zyoA:
undetectable		 5xu8A-4zyoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLY A 146
CYH A 124
SER A 122
ALA A 179
 None
 0.88A 5xu8A-5c92A:
undetectable		 5xu8A-5c92A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18

(Mus musculus) 		PF00443
(UCH) 		6 GLY A  53
LEU A  54
ASN A  64
GLN A  68
ALA A 317
PHE A 330
 None
 0.25A 5xu8A-5chvA:
30.8		 5xu8A-5chvA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18

(Mus musculus) 		PF00443
(UCH) 		6 GLY A  53
LEU A  54
SER A  65
GLN A  68
ALA A 317
PHE A 330
 None
 0.56A 5xu8A-5chvA:
30.8		 5xu8A-5chvA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23

(Homo sapiens) 		PF03097
(BRO1) 		4 LEU A 180
GLN A 184
ALA A 185
PHE A 147
 None
 0.98A 5xu8A-5crvA:
undetectable		 5xu8A-5crvA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens) 		PF00443
(UCH) 		6 GLY B  36
LEU B  37
ASN B  47
SER B  48
GLN B  51
PHE B 327
 None
 0.64A 5xu8A-5cvoB:
33.8		 5xu8A-5cvoB:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		4 ASN A 291
SER A 292
GLN A 293
ALA A 315
 None
 0.97A 5xu8A-5g5nA:
undetectable		 5xu8A-5g5nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjq UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 GLY x 105
LEU x 106
ASN x 116
GLN x 120
PHE x 449
 None
 0.86A 5xu8A-5gjqx:
undetectable		 5xu8A-5gjqx:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		5 GLY A  65
LEU A  66
ASN A  76
SER A  77
GLN A  80
 None
 0.60A 5xu8A-5gviA:
31.3		 5xu8A-5gviA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 GLY A 873
GLN A 806
ALA A 807
PHE A 802
 None
 0.99A 5xu8A-5hzrA:
undetectable		 5xu8A-5hzrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		5 GLY A 215
LEU A 216
ASN A 226
GLN A 230
PHE A 480
 None
 0.36A 5xu8A-5j7tA:
27.6		 5xu8A-5j7tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		5 GLY A 215
LEU A 216
SER A 227
GLN A 230
PHE A 480
 None
 0.62A 5xu8A-5j7tA:
27.6		 5xu8A-5j7tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		5 GLY A 215
LEU A 216
ASN A 226
GLN A 230
PHE A 480
 None
 0.29A 5xu8A-5jtvA:
30.1		 5xu8A-5jtvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 LEU A 216
SER A 227
GLN A 230
PHE A 480
 None
 0.63A 5xu8A-5jtvA:
30.1		 5xu8A-5jtvA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A  40
LEU A  41
ASN A  51
ALA A 320
 None
 0.35A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A  40
LEU A  41
SER A  52
ALA A 320
 None
 0.73A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A  41
ASN A  51
ALA A 320
PHE A 331
 None
 0.52A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A  41
SER A  52
ALA A 320
PHE A 331
 None
 0.81A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxg ADIPONECTIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF03006
(HlyIII) 		4 GLY A 275
LEU A 276
ALA A 268
PHE A 271
 None
 0.82A 5xu8A-5lxgA:
undetectable		 5xu8A-5lxgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 GLY A1684
LEU A1723
SER A1562
PHE A1559
 None
 0.92A 5xu8A-5m5pA:
undetectable		 5xu8A-5m5pA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 4 GLY A 135
LEU A 134
GLN A 138
ALA A 143
 None
 0.91A 5xu8A-5n94A:
undetectable		 5xu8A-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 5 GLY A 215
LEU A 216
ASN A 226
GLN A 230
PHE A 480
 None
 0.33A 5xu8A-5ngeA:
28.3		 5xu8A-5ngeA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 4 GLY A 215
SER A 227
GLN A 230
PHE A 480
 None
 0.64A 5xu8A-5ngeA:
28.3		 5xu8A-5ngeA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o71 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Homo sapiens) 		no annotation 4 GLY A 170
LEU A 171
GLN A 185
ALA A 610
 None
 0.52A 5xu8A-5o71A:
22.6		 5xu8A-5o71A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 GLY A 281
LEU A 282
GLN A 366
ALA A 369
 None
 0.89A 5xu8A-5oenA:
undetectable		 5xu8A-5oenA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A  69
LEU A  70
ASN A  80
GLN A  84
 None
 0.26A 5xu8A-5ohkA:
32.2		 5xu8A-5ohkA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A  69
LEU A  70
SER A  81
GLN A  84
 None
 0.66A 5xu8A-5ohkA:
32.2		 5xu8A-5ohkA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 5 GLY A 442
LEU A 443
ASN A 453
GLN A 457
PHE A 893
 None
 0.35A 5xu8A-5txkA:
32.7		 5xu8A-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 5 GLY A 442
LEU A 443
SER A 454
GLN A 457
PHE A 893
 None
 0.68A 5xu8A-5txkA:
32.7		 5xu8A-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 6 GLY A1558
LEU A1559
ASN A1569
SER A1570
GLN A1573
PHE A1900
 None
 0.72A 5xu8A-5wchA:
31.0		 5xu8A-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A 270
LEU A 271
GLN A 338
ALA A 336
 None
 0.93A 5xu8A-5xmgA:
undetectable		 5xu8A-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB4, CP29

(Pisum sativum) 		no annotation 4 GLY R 211
LEU R 210
ALA R 103
PHE R 209
 CLA  R 613 (-3.3A)
XAT  R 622 ( 4.0A)
XAT  R 622 ( 3.9A)
XAT  R 622 (-4.0A)
 0.92A 5xu8A-5xnlR:
undetectable		 5xu8A-5xnlR:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 GLY A 362
SER A 306
ALA A 286
PHE A 277
 SEB  A 360 ( 4.1A)
None
None
None
 0.66A 5xu8A-5ydjA:
undetectable		 5xu8A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 4 GLY B3804
LEU B3802
GLN B3979
ALA B3958
 None
 0.87A 5xu8A-6a70B:
undetectable		 5xu8A-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 GLY A 362
SER A 306
ALA A 286
PHE A 277
 None
 0.74A 5xu8A-6arxA:
undetectable		 5xu8A-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 GLY A 442
CYH A 604
ASN A 603
PHE A 441
 None
 0.94A 5xu8A-6fikA:
undetectable		 5xu8A-6fikA:
undetectable