SIMILAR PATTERNS OF AMINO ACIDS FOR 5XOO_A_ADNA506_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 LEU A 172
LYS A 225
GLU A 226
LEU A 161
 None
 1.44A 5xooA-1d9zA:
0.0		 5xooA-1d9zA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0z FERREDOXIN

(Halobacterium
salinarum) 		PF00111
(Fer2) 		4 LEU A 100
LYS A  96
GLU A  92
LEU A  88
 FES  A 130 (-4.4A)
None
None
None
 1.32A 5xooA-1e0zA:
undetectable		 5xooA-1e0zA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5x RHO-GEF VAV

(Mus musculus) 		PF00621
(RhoGEF) 		4 TYR A 106
LEU A  46
GLU A  75
LEU A  76
 None
 1.11A 5xooA-1f5xA:
undetectable		 5xooA-1f5xA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jb7 TELOMERE-BINDING
PROTEIN BETA SUBUNIT

(Sterkiella nova) 		PF07404
(TEBP_beta) 		4 TYR B  47
LEU B 213
LYS B 223
GLU B 222
 None
 1.09A 5xooA-1jb7B:
0.0		 5xooA-1jb7B:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 TYR N  65
LEU N  48
GLU N  42
LEU N  44
 None
None
ALB  N 500 ( 3.9A)
None
 1.41A 5xooA-1k7sN:
undetectable		 5xooA-1k7sN:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 LEU A 263
LYS A 236
GLU A 240
LEU A 243
 None
 1.23A 5xooA-1lfwA:
0.0		 5xooA-1lfwA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 TRP A 993
LEU A 521
GLU A 480
LEU A 483
 None
 1.23A 5xooA-1n5xA:
0.0		 5xooA-1n5xA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CDC4 PROTEIN
CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 TYR B 289
LEU A 146
LYS A 116
LEU A 124
 None
 1.21A 5xooA-1nexB:
undetectable		 5xooA-1nexB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 TYR A 202
TRP A 229
LYS A 271
LEU A 193
 None
 1.32A 5xooA-1pbyA:
0.0		 5xooA-1pbyA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 TYR A 314
LEU A 329
LYS A 319
LEU A 206
 None
 1.24A 5xooA-1pgjA:
undetectable		 5xooA-1pgjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 LEU A 218
LYS A 172
GLU A 201
LEU A 220
 None
 1.41A 5xooA-1qpoA:
undetectable		 5xooA-1qpoA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		4 LEU A 176
LYS A 290
GLU A 287
LEU A 151
 None
 1.32A 5xooA-1ry6A:
undetectable		 5xooA-1ry6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		4 LEU A  62
LYS A 180
GLU A 111
LEU A 107
 None
 1.36A 5xooA-1sk7A:
undetectable		 5xooA-1sk7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 TYR A 276
TRP A 105
LEU A 106
LEU A 282
 None
 1.32A 5xooA-1szqA:
undetectable		 5xooA-1szqA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3g X-LINKED
INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		PF01582
(TIR) 		4 LEU A 434
LYS A 440
GLU A 439
LEU A 446
 None
 1.36A 5xooA-1t3gA:
undetectable		 5xooA-1t3gA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		4 LEU A 129
LYS A 364
GLU A 124
LEU A 371
 None
 1.18A 5xooA-1y56A:
undetectable		 5xooA-1y56A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Bacillus
subtilis) 		PF02547
(Queuosine_synth) 		4 TYR A 229
LEU A 208
GLU A  93
LEU A  84
 None
 1.39A 5xooA-1yy3A:
undetectable		 5xooA-1yy3A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		4 TYR P  55
LEU P 132
LYS P 103
LEU P  94
 None
 0.90A 5xooA-2aizP:
undetectable		 5xooA-2aizP:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 TYR A 321
LEU A 288
GLU A 348
LEU A 345
 None
 1.28A 5xooA-2aj4A:
undetectable		 5xooA-2aj4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 TYR A 415
LEU A  17
GLU A  28
LEU A  24
 None
 1.31A 5xooA-2bmoA:
undetectable		 5xooA-2bmoA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Mycobacterium
tuberculosis) 		PF02261
(Asp_decarbox) 		4 TYR A  90
LEU A  87
GLU A  42
LEU A  38
 None
 1.19A 5xooA-2c45A:
undetectable		 5xooA-2c45A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		4 LEU X 406
LYS X 420
GLU X 416
LEU X 413
 None
 1.34A 5xooA-2de0X:
undetectable		 5xooA-2de0X:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		4 LEU A 136
LYS A  35
GLU A  43
LEU A  92
 None
 1.40A 5xooA-2g9dA:
undetectable		 5xooA-2g9dA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 290
TRP A 101
LEU A 136
LEU A 297
 None
 1.43A 5xooA-2j3hA:
undetectable		 5xooA-2j3hA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2q SURFACTIN SYNTHETASE
THIOESTERASE SUBUNIT

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 TYR B  68
LEU B   4
GLU B  41
LEU B  43
 None
 1.30A 5xooA-2k2qB:
undetectable		 5xooA-2k2qB:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 TYR A   2
LEU A 352
LYS A 371
LEU A  51
 None
 1.35A 5xooA-2p50A:
undetectable		 5xooA-2p50A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppy ENOYL-COA HYDRATASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 TYR A  32
LEU A 121
GLU A 139
LEU A 137
 None
 1.43A 5xooA-2ppyA:
undetectable		 5xooA-2ppyA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 TYR A 107
LEU A 143
GLU A 152
LEU A 103
 None
 1.18A 5xooA-2rghA:
undetectable		 5xooA-2rghA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkj TYROSYL-TRNA
SYNTHETASE

(Neurospora
crassa) 		PF00579
(tRNA-synt_1b) 		4 TYR A 124
TRP A 174
LEU A 173
LEU A 117
 None
 1.33A 5xooA-2rkjA:
undetectable		 5xooA-2rkjA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		4 LEU A 439
LYS A   5
GLU A 494
LEU A 497
 None
 1.25A 5xooA-2v8jA:
undetectable		 5xooA-2v8jA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		4 LEU A 276
LYS A  91
GLU A  90
LEU A 104
 None
 1.44A 5xooA-2wk8A:
undetectable		 5xooA-2wk8A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 TYR A 576
LEU A 401
GLU A 408
LEU A 533
 None
 1.18A 5xooA-2x6kA:
3.7		 5xooA-2x6kA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgv PSIV CAPSID
N-TERMINAL DOMAIN

(Microcebus
murinus) 		PF00607
(Gag_p24) 		4 TYR A  39
TRP A  22
LEU A  56
LEU A 125
 None
 1.35A 5xooA-2xgvA:
undetectable		 5xooA-2xgvA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		4 LEU A   7
LYS A  65
GLU A  69
LEU A  93
 None
 1.45A 5xooA-2ywrA:
undetectable		 5xooA-2ywrA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 138
LYS A 117
GLU A 212
LEU A 216
 None
NDP  A3001 (-3.6A)
None
None
 1.29A 5xooA-3a14A:
undetectable		 5xooA-3a14A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a45 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 TYR A 109
LEU A  14
GLU A 228
LEU A 225
 None
 1.41A 5xooA-3a45A:
undetectable		 5xooA-3a45A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		4 TYR A 254
LEU A 264
GLU A  34
LEU A 186
 None
None
GOL  A 506 (-3.2A)
GOL  A 506 (-4.3A)
 1.38A 5xooA-3bh1A:
undetectable		 5xooA-3bh1A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlt ESTERASE D

(Lactobacillus
rhamnosus) 		PF12146
(Hydrolase_4) 		4 LEU A 199
LYS A 102
GLU A 105
LEU A 173
 None
 1.24A 5xooA-3dltA:
undetectable		 5xooA-3dltA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TYR A 217
LEU A 193
GLU A 156
LEU A 155
 None
 0.83A 5xooA-3g4fA:
undetectable		 5xooA-3g4fA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 TYR A 463
LEU A 358
GLU A 354
LEU A 372
 TPQ  A 461 ( 4.5A)
None
None
None
 1.35A 5xooA-3higA:
undetectable		 5xooA-3higA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		4 TYR A 180
TRP A 240
LEU A 230
LEU A 212
 None
 1.24A 5xooA-3hiqA:
undetectable		 5xooA-3hiqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		4 TYR A 180
TRP A 240
LEU A 230
LEU A 212
 None
 1.21A 5xooA-3hiwA:
undetectable		 5xooA-3hiwA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A 179
LYS A  76
GLU A 260
LEU A 264
 None
NDP  A 300 ( 4.8A)
NDP  A 300 (-3.2A)
None
 1.46A 5xooA-3hwrA:
undetectable		 5xooA-3hwrA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 TYR A 517
LEU A 399
GLU A 406
LEU A 475
 None
 1.42A 5xooA-3ihyA:
undetectable		 5xooA-3ihyA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 TYR A 277
LEU A 352
GLU A 398
LEU A 397
 None
 1.23A 5xooA-3j4pA:
undetectable		 5xooA-3j4pA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		4 TYR A 189
LEU A 135
GLU A 198
LEU A 206
 None
 1.46A 5xooA-3khsA:
undetectable		 5xooA-3khsA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		4 TYR A 127
LEU A 120
LYS A  10
LEU A  32
 None
 1.30A 5xooA-3kyeA:
undetectable		 5xooA-3kyeA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfk MARR LIKE PROTEIN,
TVG0766549

(Thermoplasma
volcanium) 		no annotation 4 LEU A  67
LYS A  80
GLU A  85
LEU A  51
 None
 1.17A 5xooA-3lfkA:
undetectable		 5xooA-3lfkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 TRP A 106
LEU A 102
GLU A 141
LEU A 142
 None
 1.38A 5xooA-3m1tA:
undetectable		 5xooA-3m1tA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 TYR A 508
LEU A 596
LYS A 545
LEU A 513
 None
 1.41A 5xooA-3ppcA:
undetectable		 5xooA-3ppcA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		4 TYR A 340
LEU A  50
GLU A  83
LEU A  84
 None
 1.30A 5xooA-3pshA:
undetectable		 5xooA-3pshA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 TYR A 673
LEU A 793
GLU A 790
LEU A 639
 None
 1.29A 5xooA-3tsyA:
undetectable		 5xooA-3tsyA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uz0 STAGE III
SPORULATION PROTEIN
AH

(Bacillus
subtilis) 		PF12685
(SpoIIIAH) 		4 LEU A 113
LYS A 156
GLU A 159
LEU A 171
 None
 1.17A 5xooA-3uz0A:
undetectable		 5xooA-3uz0A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 216
LYS A 212
GLU A 262
LEU A 258
 None
 0.88A 5xooA-3zx1A:
undetectable		 5xooA-3zx1A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 334
LYS A 534
GLU A 489
LEU A 492
 None
 1.32A 5xooA-3zz1A:
undetectable		 5xooA-3zz1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 265
LYS A 275
GLU A 274
LEU A 259
 None
 1.38A 5xooA-4e3cA:
4.5		 5xooA-4e3cA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		4 LEU A  54
LYS A 315
GLU A 319
LEU A 322
 None
 1.38A 5xooA-4emyA:
undetectable		 5xooA-4emyA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp8 ANTIBODY C05, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  79
LEU H   4
GLU H  76
LEU H  29
 None
 1.32A 5xooA-4fp8H:
undetectable		 5xooA-4fp8H:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 TYR A 417
LEU A  19
GLU A  30
LEU A  26
 None
 1.43A 5xooA-4hjlA:
undetectable		 5xooA-4hjlA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc5 TRANSMEMBRANE
PROTEIN 173

(Mus musculus) 		PF15009
(TMEM173) 		4 TYR A 239
LEU A 167
GLU A 259
LEU A 197
 None
 1.18A 5xooA-4jc5A:
undetectable		 5xooA-4jc5A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 LEU A 124
LYS A  97
GLU A  99
LEU A 101
 LEU  A 124 ( 0.5A)
LYS  A  97 ( 0.0A)
GLU  A  99 ( 0.6A)
LEU  A 101 ( 0.6A)
 1.33A 5xooA-4kqnA:
undetectable		 5xooA-4kqnA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN

(Homo sapiens) 		PF15009
(TMEM173) 		4 TYR A 240
LEU A 172
GLU A 260
LEU A 198
 1SY  A 500 (-4.7A)
None
1SY  A 500 (-4.2A)
None
 1.32A 5xooA-4ksyA:
undetectable		 5xooA-4ksyA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		4 LEU A 164
LYS A 109
GLU A 254
LEU A 238
 None
 1.20A 5xooA-4n06A:
undetectable		 5xooA-4n06A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 TYR A 111
LEU A 106
GLU A  23
LEU A  19
 None
 1.38A 5xooA-4npaA:
undetectable		 5xooA-4npaA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		4 LEU A 242
LYS A 291
GLU A 285
LEU A 282
 None
 1.20A 5xooA-4qlbA:
undetectable		 5xooA-4qlbA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxr STIMULATOR OF
INTERFERON GENES
PROTEIN

(Homo sapiens) 		PF15009
(TMEM173) 		4 TYR A 240
LEU A 168
GLU A 260
LEU A 198
 None
 1.23A 5xooA-4qxrA:
undetectable		 5xooA-4qxrA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxr STIMULATOR OF
INTERFERON GENES
PROTEIN

(Homo sapiens) 		PF15009
(TMEM173) 		4 TYR A 240
LEU A 172
GLU A 260
LEU A 198
 None
 1.31A 5xooA-4qxrA:
undetectable		 5xooA-4qxrA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		4 TYR A 153
LEU A 173
LYS A 228
GLU A 224
 None
 1.40A 5xooA-4s1aA:
undetectable		 5xooA-4s1aA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		4 TYR A 495
LEU A 344
GLU A 456
LEU A 523
 None
 1.17A 5xooA-4sliA:
undetectable		 5xooA-4sliA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099

(Methanocaldococcus
jannaschii) 		PF04476
(4HFCP_synth) 		4 TYR A 126
LEU A 150
GLU A 132
LEU A 134
 None
 1.43A 5xooA-4u9pA:
undetectable		 5xooA-4u9pA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux3 MITOTIC CHROMOSOME
DETERMINANT-RELATED
PROTEIN
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04825
(Rad21_Rec8_N) 		4 LEU B  75
LYS A 173
GLU A 176
LEU A 179
 None
 1.34A 5xooA-4ux3B:
undetectable		 5xooA-4ux3B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 TRP A 993
LEU A 520
GLU A 479
LEU A 482
 None
 1.20A 5xooA-4yswA:
undetectable		 5xooA-4yswA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 548
TRP A 418
LEU A 482
LEU A 557
 None
 1.18A 5xooA-5a7mA:
undetectable		 5xooA-5a7mA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c14 PLATELET ENDOTHELIAL
CELL ADHESION
MOLECULE

(Homo sapiens) 		PF13895
(Ig_2) 		4 TYR B  75
LEU B  26
LYS B  50
LEU B  98
 None
 1.00A 5xooA-5c14B:
undetectable		 5xooA-5c14B:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT

(Azospira oryzae) 		PF13247
(Fer4_11) 		4 TYR B 182
LEU B 288
GLU B  50
LEU B 133
 None
 1.45A 5xooA-5e7oB:
undetectable		 5xooA-5e7oB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg6 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A 621
LEU A 578
GLU A 628
LEU A 663
 None
None
EDO  A 703 (-3.1A)
EDO  A 703 ( 4.2A)
 1.16A 5xooA-5fg6A:
undetectable		 5xooA-5fg6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		4 TYR A 143
LEU A 221
GLU A1373
LEU A1337
 None
 1.46A 5xooA-5fguA:
undetectable		 5xooA-5fguA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 2, TFB2
RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 5, TFB5

(Saccharomyces
cerevisiae) 		PF06331
(Tfb5)
no annotation 		4 TRP W 483
LEU X   9
GLU X  33
LEU W 458
 None
 1.42A 5xooA-5fmfW:
undetectable		 5xooA-5fmfW:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grm STIMULATOR OF
INTERFERON GENES
PROTEIN

(Rattus
norvegicus) 		no annotation 4 TYR A 240
LEU A 172
GLU A 260
LEU A 198
 None
 1.42A 5xooA-5grmA:
undetectable		 5xooA-5grmA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwy PHOSPHATIDYLGLYCEROP
HOSPHATASE B

(Escherichia
coli) 		PF01569
(PAP2) 		4 TRP A 151
LEU A 204
GLU A  33
LEU A  38
 None
 1.20A 5xooA-5jwyA:
undetectable		 5xooA-5jwyA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF01180
(DHO_dh)
PF10418
(DHODB_Fe-S_bind) 		4 TYR A  36
LEU B  40
GLU B  32
LEU B  29
 None
 0.91A 5xooA-5kswA:
undetectable		 5xooA-5kswA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A  97
LYS A 138
GLU A 141
LEU A 144
 None
 1.30A 5xooA-5kxjA:
undetectable		 5xooA-5kxjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4A
CAPSID PROTEIN VP4B

(Nora virus) 		no annotation 4 TYR C 141
LEU B 131
LYS B  62
LEU B  65
 None
 1.25A 5xooA-5mm2C:
undetectable		 5xooA-5mm2C:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5a PEREGRIN

(Homo sapiens) 		no annotation 4 TYR A 687
LEU A 644
GLU A 694
LEU A 729
 None
 1.18A 5xooA-5o5aA:
undetectable		 5xooA-5o5aA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 4 TYR C 179
LEU C 208
LYS C 232
LEU C 240
 None
 1.39A 5xooA-5oktC:
4.6		 5xooA-5oktC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 TYR D 487
LEU D 495
GLU D 532
LEU E 385
 None
 1.30A 5xooA-5uz5D:
undetectable		 5xooA-5uz5D:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w66 RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN7

(Saccharomyces
cerevisiae) 		no annotation 4 TYR P 210
LEU P 105
GLU P 151
LEU P 154
 None
 1.40A 5xooA-5w66P:
undetectable		 5xooA-5w66P:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wco NS2

(Salmon isavirus) 		no annotation 4 LEU A 109
LYS A   1
GLU A   3
LEU A  44
 None
 1.12A 5xooA-5wcoA:
undetectable		 5xooA-5wcoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		4 TYR A -14
TRP A 162
LEU A 683
LEU A 192
 None
 1.11A 5xooA-5wx1A:
undetectable		 5xooA-5wx1A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 4 TYR A 830
LEU A 754
GLU A 544
LEU A 798
 None
 1.27A 5xooA-5xiiA:
undetectable		 5xooA-5xiiA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE

(Hydra vulgaris) 		no annotation 4 LEU A 236
LYS A 244
GLU A 304
LEU A 317
 None
 0.75A 5xooA-5xomA:
58.0		 5xooA-5xomA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 TYR A 188
LEU A 327
GLU A1453
LEU A1455
 None
 1.19A 5xooA-5xyaA:
undetectable		 5xooA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
PF08163
(NUC194) 		4 TYR C 175
LEU C 196
GLU C 203
LEU A 312
 None
 1.40A 5xooA-5y3rC:
undetectable		 5xooA-5y3rC:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 4 LEU A 925
LYS A1022
GLU A1026
LEU A1030
 None
 0.86A 5xooA-5zq6A:
undetectable		 5xooA-5zq6A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 4 LEU A 794
LYS A 825
GLU A 802
LEU A 798
 None
 1.42A 5xooA-6b3yA:
undetectable		 5xooA-6b3yA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9s METHYLPHOSPHONATE
SYNTHASE

(Nitrosopumilus
maritimus) 		no annotation 4 TYR A 110
LEU A 205
GLU A 128
LEU A 203
 None
 1.34A 5xooA-6b9sA:
undetectable		 5xooA-6b9sA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 TYR A 306
LEU A 291
LYS A 417
LEU A 348
 None
 1.29A 5xooA-6begA:
undetectable		 5xooA-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccu GLUCOSE-INDUCED
DEGRADATION PROTEIN
4 HOMOLOG

(Homo sapiens) 		no annotation 4 LEU A 284
LYS A 236
GLU A 237
LEU A 159
 None
 1.33A 5xooA-6ccuA:
undetectable		 5xooA-6ccuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cd8 GLUCOSE-INDUCED
DEGRADATION PROTEIN
4 HOMOLOG

(Homo sapiens) 		no annotation 4 LEU A 284
LYS A 236
GLU A 237
LEU A 159
 None
 1.31A 5xooA-6cd8A:
undetectable		 5xooA-6cd8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e2q -

(-) 		no annotation 4 TYR A 266
LEU A 309
GLU A 311
LEU A 314
 None
 1.17A 5xooA-6e2qA:
undetectable		 5xooA-6e2qA:
undetectable