SIMILAR PATTERNS OF AMINO ACIDS FOR 5XIW_D_LOCD503_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 128
LEU A 319
THR A 301
ALA A 287
ILE A 274
 None
 1.21A 5xiwD-1bkhA:
2.8		 5xiwD-1bkhA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 ALA A 258
ALA A 251
ILE A 249
LYS A 277
ALA A 275
 None
 0.91A 5xiwD-1dkdA:
undetectable		 5xiwD-1dkdA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 LEU A 259
ASN A 209
ALA A 207
ILE A 203
ILE A 167
 None
 1.21A 5xiwD-1dysA:
undetectable		 5xiwD-1dysA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		5 LEU A 197
THR A 241
ALA A 239
ILE A   3
ALA A 226
 None
 0.90A 5xiwD-1f6yA:
2.2		 5xiwD-1f6yA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1365
ALA A1392
ILE A1394
ALA A1375
ILE A1410
 None
 0.95A 5xiwD-1ofeA:
undetectable		 5xiwD-1ofeA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK

(Escherichia
coli) 		PF04107
(GCS2) 		5 LEU A 164
ALA A 259
ILE A 331
ALA A 330
ILE A 318
 None
 1.26A 5xiwD-1r8gA:
undetectable		 5xiwD-1r8gA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkv HOMOSERINE KINASE

(Pseudomonas
aeruginosa) 		PF12710
(HAD) 		5 LEU A  80
LEU A 191
ALA A 150
ILE A 148
ALA A   4
 None
 0.97A 5xiwD-1rkvA:
4.0		 5xiwD-1rkvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		5 ALA A 149
LEU A 147
ALA A 107
ILE A  69
ALA A  91
 None
 0.69A 5xiwD-1ur4A:
2.9		 5xiwD-1ur4A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 336
LEU A 286
ALA A 348
THR A 235
ALA A 292
 None
 0.92A 5xiwD-1wopA:
undetectable		 5xiwD-1wopA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		5 CYH A 140
LEU A 142
THR A 267
ILE A 218
ALA A 131
 None
 1.03A 5xiwD-1xcrA:
undetectable		 5xiwD-1xcrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		5 LEU A   6
LEU A 569
LEU A 573
ASN A 572
ILE A   8
 None
 1.23A 5xiwD-1xdpA:
undetectable		 5xiwD-1xdpA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		5 LEU P  77
ALA P  85
ILE P  83
ALA P  74
ILE P 107
 None
 0.83A 5xiwD-2aieP:
undetectable		 5xiwD-2aieP:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A  73
ALA A 102
ILE A 234
ALA A 286
ILE A 161
 None
 1.10A 5xiwD-2d0iA:
2.1		 5xiwD-2d0iA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.23A 5xiwD-2ffhA:
undetectable		 5xiwD-2ffhA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjr REPRESSOR PROTEIN CI

(Escherichia
virus 186) 		PF07022
(Phage_CI_repr)
PF16452
(Phage_CI_C) 		5 CYH A  57
LEU A  59
LEU A  65
ILE A  17
ALA A  20
 None
 1.23A 5xiwD-2fjrA:
undetectable		 5xiwD-2fjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		5 LEU A 147
ALA A 297
ASN A  81
ALA A  87
ILE A  96
 None
 1.16A 5xiwD-2iksA:
undetectable		 5xiwD-2iksA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j42 C2 TOXIN
COMPONENT-II

(Clostridium
botulinum) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 LEU A 520
LEU A 518
ALA A 523
LEU A 490
ALA A 505
 None
 1.32A 5xiwD-2j42A:
undetectable		 5xiwD-2j42A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 324
LEU A 239
ALA A 293
LEU A 297
ASN A 300
 None
 1.31A 5xiwD-2jiiA:
undetectable		 5xiwD-2jiiA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		5 LEU A 163
ALA A 161
ILE A 140
LYS A 166
ALA A 138
 None
 1.32A 5xiwD-2khoA:
undetectable		 5xiwD-2khoA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la4 NUCLEAR AND
CYTOPLASMIC
POLYADENYLATED
RNA-BINDING PROTEIN
PUB1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 ALA A 395
THR A 341
ALA A 343
ILE A 345
ILE A 381
 None
 0.87A 5xiwD-2la4A:
undetectable		 5xiwD-2la4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.29A 5xiwD-2ng1A:
3.4		 5xiwD-2ng1A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.88A 5xiwD-2oi6A:
undetectable		 5xiwD-2oi6A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		5 LEU A 189
LEU A 247
ALA A 210
ILE A 207
ILE A 181
 None
 1.13A 5xiwD-2q7xA:
4.8		 5xiwD-2q7xA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 167
LEU A  65
ALA A 123
ILE A 125
ILE A  76
 None
 0.85A 5xiwD-2v7bA:
undetectable		 5xiwD-2v7bA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmd DISCOIDIN-2

(Dictyostelium
discoideum) 		PF00754
(F5_F8_type_C)
PF09458
(H_lectin) 		5 CYH A  10
LEU A  11
THR A  96
ALA A 153
ILE A 134
 None
 1.21A 5xiwD-2vmdA:
undetectable		 5xiwD-2vmdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 LEU A 504
LEU A 412
THR A 450
ILE A 459
ALA A 474
 None
 1.27A 5xiwD-2w2gA:
undetectable		 5xiwD-2w2gA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 598
THR A 724
ALA A 715
ILE A 712
ILE A  79
 PGR  A1742 (-4.0A)
None
None
None
None
 1.01A 5xiwD-2xe4A:
2.6		 5xiwD-2xe4A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 CYH A 351
ALA A 349
THR A 435
ILE A 311
ALA A 377
 None
 1.06A 5xiwD-2xijA:
4.5		 5xiwD-2xijA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr3 MYOSIN LIGHT CHAIN
KINASE, SMOOTH
MUSCLE

(Homo sapiens) 		PF07679
(I-set) 		5 CYH A  92
ALA A  94
THR A  58
ALA A  64
ILE A  43
 None
 1.25A 5xiwD-2yr3A:
undetectable		 5xiwD-2yr3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]

(Methanocaldococcus
jannaschii) 		PF13847
(Methyltransf_31) 		5 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.77A 5xiwD-2yxdA:
3.3		 5xiwD-2yxdA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 CYH A  49
LEU A  51
THR A 218
ILE A  93
ALA A  91
 None
 1.16A 5xiwD-3bwqA:
undetectable		 5xiwD-3bwqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 1.00A 5xiwD-3bz5A:
undetectable		 5xiwD-3bz5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.66A 5xiwD-3ctzA:
undetectable		 5xiwD-3ctzA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		5 LEU A  72
LEU A   8
ALA A  55
ILE A  42
ALA A  41
 None
 1.07A 5xiwD-3fkqA:
2.7		 5xiwD-3fkqA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fou QUINOL-CYTOCHROME C
REDUCTASE, RIESKE
IRON-SULFUR SUBUNIT

(Thermus
thermophilus) 		PF00355
(Rieske) 		5 LEU A 178
ALA A 189
ASN A 101
ALA A  84
ALA A 127
 None
 1.21A 5xiwD-3fouA:
undetectable		 5xiwD-3fouA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		5 LEU A 275
LEU A 282
LEU A 266
THR A 214
ALA A 204
 None
 1.12A 5xiwD-3gbzA:
undetectable		 5xiwD-3gbzA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		5 LEU A 106
LEU A 113
LEU A  95
ILE A 293
ALA A 292
 None
 0.72A 5xiwD-3jv9A:
undetectable		 5xiwD-3jv9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		5 LEU A 113
LEU A  95
ILE A 293
ALA A 292
ILE A 145
 None
 1.31A 5xiwD-3jv9A:
undetectable		 5xiwD-3jv9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 LEU A  63
ASN A  81
THR A   5
ALA A   7
ILE A  85
 None
 1.31A 5xiwD-3k53A:
2.9		 5xiwD-3k53A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbg 30S RIBOSOMAL
PROTEIN S4E

(Thermoplasma
acidophilum) 		PF00900
(Ribosomal_S4e)
PF01479
(S4) 		5 LEU A  41
LEU A  48
ALA A  57
ASN A  89
ILE A  86
 None
 1.12A 5xiwD-3kbgA:
undetectable		 5xiwD-3kbgA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.17A 5xiwD-3klbA:
4.3		 5xiwD-3klbA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 162
LEU A 169
ALA A 316
ILE A 194
ALA A 168
 None
 0.98A 5xiwD-3m6iA:
3.8		 5xiwD-3m6iA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 LEU A-209
LEU A-226
ASN A-224
ILE A-216
LYS A-221
 None
 1.16A 5xiwD-3n94A:
undetectable		 5xiwD-3n94A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU B 359
ALA B 335
LEU B 339
THR B  60
ALA B 358
 None
 1.29A 5xiwD-3pr2B:
2.1		 5xiwD-3pr2B:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 525
LEU A 498
LEU A 503
THR A 459
ILE A 486
 None
 1.08A 5xiwD-3rg1A:
undetectable		 5xiwD-3rg1A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		5 LEU A 379
LEU A  12
ALA A 243
ILE A 414
ALA A 412
 None
 1.17A 5xiwD-3sg1A:
undetectable		 5xiwD-3sg1A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 ALA A 242
THR A 388
ILE A 403
ALA A 375
ILE A 414
 None
 1.24A 5xiwD-3vcyA:
undetectable		 5xiwD-3vcyA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 CYH A  28
ASN A  18
ALA A  16
ILE A  49
ILE A   6
 None
 1.32A 5xiwD-3vr5A:
2.3		 5xiwD-3vr5A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		5 LEU A 107
ALA A 249
ILE A 173
ALA A 172
ILE A 184
 None
 0.94A 5xiwD-3wrcA:
undetectable		 5xiwD-3wrcA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		5 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.97A 5xiwD-3wtcA:
6.7		 5xiwD-3wtcA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		5 CYH A  34
ASN A 100
ILE A  51
ALA A  97
ILE A  71
 None
 1.05A 5xiwD-4d7pA:
undetectable		 5xiwD-4d7pA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		5 ALA A 283
ASN A 218
ILE A 260
ALA A 257
ILE A 222
 None
 1.11A 5xiwD-4fmcA:
undetectable		 5xiwD-4fmcA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.28A 5xiwD-4hrlA:
undetectable		 5xiwD-4hrlA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb8 DARPIN C7_16

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU P  84
ALA P 104
ASN P 135
ILE P  95
ALA P  87
 None
 1.31A 5xiwD-4jb8P:
undetectable		 5xiwD-4jb8P:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 480
THR A 298
ILE A  60
ALA A  58
ILE A 268
 None
 1.13A 5xiwD-4lc9A:
4.9		 5xiwD-4lc9A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nez ENGINEERED PROTEIN
OR276

(synthetic
construct) 		no annotation 5 LEU A 103
LEU A 148
ILE A  89
ALA A 145
ILE A 130
 None
 1.14A 5xiwD-4nezA:
undetectable		 5xiwD-4nezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  17
LEU A 171
ALA A 139
LEU A 143
THR A 150
 None
 1.24A 5xiwD-4nf2A:
undetectable		 5xiwD-4nf2A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhw GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A  81
ASN A  80
ALA A 170
ALA A 109
ILE A 102
 None
 1.20A 5xiwD-4nhwA:
undetectable		 5xiwD-4nhwA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nim VERSICOLORIN
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 LEU A  26
ALA A 230
ILE A  12
ALA A  92
ILE A  88
 None
 1.02A 5xiwD-4nimA:
7.5		 5xiwD-4nimA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.89A 5xiwD-4twiA:
3.9		 5xiwD-4twiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 LEU A 386
ALA A 434
LEU A 438
ALA A 318
LYS A 319
 None
 1.25A 5xiwD-4u3tA:
undetectable		 5xiwD-4u3tA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 ALA A 685
LEU A 687
THR A 614
ALA A 616
ILE A 659
 None
 1.16A 5xiwD-4u7mA:
undetectable		 5xiwD-4u7mA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		5 LEU A 327
ALA A 347
ILE A  18
ALA A 136
ILE A  16
 None
 1.15A 5xiwD-4usqA:
undetectable		 5xiwD-4usqA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Streptococcus
pyogenes) 		PF04321
(RmlD_sub_bind) 		5 LEU A  18
ALA A 192
THR A  95
ILE A   4
ILE A   2
 None
None
MRD  A 302 (-2.9A)
None
None
 0.92A 5xiwD-4wpgA:
6.1		 5xiwD-4wpgA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		5 LEU A 283
LEU A 238
ALA A 294
ILE A 270
LYS A 246
 None
 1.32A 5xiwD-4wu0A:
undetectable		 5xiwD-4wu0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdj RUBISCO LARGE
SUBUNIT-BINDING
PROTEIN SUBUNIT
ALPHA, CHLOROPLASTIC

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		5 ALA A 258
ALA A 251
ILE A 249
LYS A 277
ALA A 275
 None
 1.00A 5xiwD-5cdjA:
undetectable		 5xiwD-5cdjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Acinetobacter
nosocomialis;
Escherichia
coli) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		5 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
 None
 1.29A 5xiwD-5cfvA:
undetectable		 5xiwD-5cfvA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 204
ALA A 227
LEU A 190
THR A 159
ILE A 155
 None
 1.18A 5xiwD-5cweA:
undetectable		 5xiwD-5cweA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyl FIMBRIAL SUBUNIT
CUPB6

(Pseudomonas
aeruginosa) 		PF00419
(Fimbrial) 		5 LEU A  42
LEU A 153
ASN A 152
ALA A 191
ILE A  86
 None
 1.30A 5xiwD-5cylA:
undetectable		 5xiwD-5cylA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 373
LEU A 407
ALA A 441
ALA A 437
ILE A 446
 None
 1.11A 5xiwD-5dgtA:
2.4		 5xiwD-5dgtA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1v POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		no annotation 5 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.92A 5xiwD-5e1vB:
undetectable		 5xiwD-5e1vB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey2 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus cereus) 		PF06018
(CodY)
PF08222
(HTH_CodY) 		5 ASN A 219
ALA A 186
ILE A 206
ALA A 207
ILE A 190
 None
 0.97A 5xiwD-5ey2A:
undetectable		 5xiwD-5ey2A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 239
LEU A 463
ILE A 268
ALA A 279
ILE A 476
 None
 1.19A 5xiwD-5i4eA:
undetectable		 5xiwD-5i4eA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 LEU A3806
LEU A3789
ASN A3791
ILE A3799
LYS A3794
 None
 1.32A 5xiwD-5ii5A:
undetectable		 5xiwD-5ii5A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 LEU A3806
LEU A3789
THR A3912
ILE A3799
LYS A3794
 None
 1.20A 5xiwD-5ii5A:
undetectable		 5xiwD-5ii5A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 LEU A4108
LEU A4091
THR A4214
ILE A4101
LYS A4096
 None
 1.26A 5xiwD-5iicA:
undetectable		 5xiwD-5iicA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 LEU A 346
ALA A 355
LYS A 351
ALA A 315
ILE A 404
 None
 1.30A 5xiwD-5jfmA:
undetectable		 5xiwD-5jfmA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.07A 5xiwD-5jqeA:
undetectable		 5xiwD-5jqeA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 386
ALA A 434
LEU A 438
ALA A 318
LYS A 319
 None
 1.22A 5xiwD-5kshA:
undetectable		 5xiwD-5kshA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		5 LEU B 358
ALA B 334
LEU B 338
THR B  59
ALA B 357
 None
 1.27A 5xiwD-5kzmB:
undetectable		 5xiwD-5kzmB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB

(Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C) 		5 LEU A 121
ASN A 155
ILE A 148
ALA A 149
ILE A 159
 None
 1.00A 5xiwD-5l75A:
undetectable		 5xiwD-5l75A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.28A 5xiwD-5le9A:
undetectable		 5xiwD-5le9A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A 206
ALA A 226
ASN A 257
ILE A 217
ALA A 209
 None
 1.30A 5xiwD-5le9A:
undetectable		 5xiwD-5le9A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 266
ALA A 234
ILE A 236
ALA A 226
ILE A 271
 None
 0.98A 5xiwD-5lm7A:
undetectable		 5xiwD-5lm7A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxr RNA-BINDING PROTEIN
7

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU A  69
ALA A  33
LEU A  29
ILE A  82
ILE A  80
 None
 1.05A 5xiwD-5lxrA:
undetectable		 5xiwD-5lxrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.18A 5xiwD-5mdhA:
undetectable		 5xiwD-5mdhA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA

(Nostoc sp. PCC
7120) 		no annotation 5 LEU A  84
ALA A  80
LEU A  41
ALA A  58
ILE A  23
 None
 0.87A 5xiwD-5n3uA:
undetectable		 5xiwD-5n3uA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A1896
ALA A1895
THR A1913
ILE A2014
ALA A2013
 None
None
ADP  A4801 (-3.8A)
None
None
 1.24A 5xiwD-5nugA:
undetectable		 5xiwD-5nugA:
1.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nus P34

(Chaetomium
thermophilum) 		no annotation 5 LEU A 239
LEU A 270
ASN A  51
ILE A 258
ALA A 260
 None
 1.32A 5xiwD-5nusA:
4.3		 5xiwD-5nusA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2s DARPIN K27

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU B  94
ALA B 114
ASN B 145
ILE B 105
ALA B  97
 None
 1.31A 5xiwD-5o2sB:
undetectable		 5xiwD-5o2sB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 LEU T1803
ALA T1786
LEU T1744
ASN T1741
ILE T1766
 None
 1.20A 5xiwD-5ojsT:
undetectable		 5xiwD-5ojsT:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2i NUCLEOSIDE
DIPHOSPHATE KINASE

(Naegleria
fowleri) 		PF00334
(NDK) 		5 ALA A  14
THR A  93
ILE A   8
ALA A   9
ILE A  90
 None
 1.31A 5xiwD-5u2iA:
undetectable		 5xiwD-5u2iA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A 379
LEU A  12
ALA A 242
ILE A 414
ALA A 412
 None
 1.23A 5xiwD-5u4hA:
undetectable		 5xiwD-5u4hA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 157
ALA A 161
LEU A  13
THR A   2
ALA A 222
 None
 1.28A 5xiwD-5ujuA:
undetectable		 5xiwD-5ujuA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdy HEAT SHOCK PROTEIN
HTRA

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 310
ASN A 297
LYS A 283
ALA A 275
ILE A 243
 None
 1.26A 5xiwD-5xdyA:
undetectable		 5xiwD-5xdyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 135
THR A 228
ALA A 226
ILE A 224
ILE A 217
 None
 1.10A 5xiwD-6amsA:
undetectable		 5xiwD-6amsA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
 None
 1.06A 5xiwD-6apxA:
undetectable		 5xiwD-6apxA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 LEU A 223
ALA A 219
THR A 232
ILE A 356
ALA A 362
 None
 1.21A 5xiwD-6bz0A:
undetectable		 5xiwD-6bz0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 5 LEU A 115
LEU A 118
ALA A  72
ALA A 160
ALA A  37
 None
 0.95A 5xiwD-6c62A:
undetectable		 5xiwD-6c62A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 LEU A 508
ALA A 485
ALA A 542
ALA A 562
ILE A 555
 None
 1.01A 5xiwD-6cipA:
undetectable		 5xiwD-6cipA:
17.65