SIMILAR PATTERNS OF AMINO ACIDS FOR 5XIW_D_LOCD503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgx TP7 MAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 199
ALA H 194
VAL H 193
 None
 0.53A 5xiwC-1bgxH:
undetectable		 5xiwC-1bgxH:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bog ANTIBODY (CB 4-1)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 202
ALA B 197
VAL B 196
 None
 0.55A 5xiwC-1bogB:
undetectable		 5xiwC-1bogB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1e CATALYTIC ANTIBODY
1E9 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.51A 5xiwC-1c1eH:
undetectable		 5xiwC-1c1eH:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 SER H 216
ALA H 211
VAL H 210
 None
 0.46A 5xiwC-1etzH:
undetectable		 5xiwC-1etzH:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3d CATALYTIC ANTIBODY
4B2

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 211
ALA H 206
VAL H 205
 None
 0.53A 5xiwC-1f3dH:
undetectable		 5xiwC-1f3dH:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4w ANTIBODY S-20-4, FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 207
ALA H 202
VAL H 201
 None
 0.55A 5xiwC-1f4wH:
undetectable		 5xiwC-1f4wH:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		3 SER A 238
ALA A 249
VAL A 248
 None
 0.54A 5xiwC-1f89A:
0.1		 5xiwC-1f89A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.50A 5xiwC-1fptH:
0.0		 5xiwC-1fptH:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 204
ALA H 199
VAL H 198
 None
 0.52A 5xiwC-1h3pH:
undetectable		 5xiwC-1h3pH:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.46A 5xiwC-1ibgH:
undetectable		 5xiwC-1ibgH:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igt IGG2A INTACT
ANTIBODY - MAB231

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.48A 5xiwC-1igtB:
undetectable		 5xiwC-1igtB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1il1 MONOCLONAL ANTIBODY
G3-519 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 211
ALA A 206
VAL A 205
 None
 0.53A 5xiwC-1il1A:
undetectable		 5xiwC-1il1A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 SER B  64
ALA B  40
VAL B  39
 None
 0.47A 5xiwC-1jtdB:
undetectable		 5xiwC-1jtdB:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk3 9D7 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 209
ALA H 204
VAL H 203
 None
 0.51A 5xiwC-1lk3H:
undetectable		 5xiwC-1lk3H:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ngq N1G9 (IGG1-LAMBDA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 210
ALA H 205
VAL H 204
 None
 0.52A 5xiwC-1ngqH:
undetectable		 5xiwC-1ngqH:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ob1 ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 203
ALA B 198
VAL B 197
 None
 0.53A 5xiwC-1ob1B:
undetectable		 5xiwC-1ob1B:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		3 SER A 130
ALA A 174
VAL A 185
 None
 0.48A 5xiwC-1p3cA:
undetectable		 5xiwC-1p3cA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg7 MURINE ANTIBODY 6A6
FAB FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER X 203
ALA X 198
VAL X 197
 None
 0.50A 5xiwC-1pg7X:
undetectable		 5xiwC-1pg7X:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		3 SER D 780
ALA D 767
VAL D 766
 None
 0.43A 5xiwC-1pytD:
undetectable		 5xiwC-1pytD:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r24 PROTEIN (IGG3-KAPPA
ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 211
ALA B 207
VAL B 206
 None
 0.54A 5xiwC-1r24B:
undetectable		 5xiwC-1r24B:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfd FAB M82G2, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.50A 5xiwC-1rfdH:
undetectable		 5xiwC-1rfdH:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN

(Mus musculus) 		no annotation 3 SER H 208
ALA H 203
VAL H 202
 None
 0.52A 5xiwC-1t66H:
undetectable		 5xiwC-1t66H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 SER A 239
ALA A 174
VAL A 173
 None
 0.50A 5xiwC-1t8hA:
undetectable		 5xiwC-1t8hA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 SER A 164
ALA A 182
VAL A 175
 None
 0.55A 5xiwC-1wydA:
undetectable		 5xiwC-1wydA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 SER A 523
ALA A  48
VAL A  47
 None
 0.53A 5xiwC-2aj4A:
undetectable		 5xiwC-2aj4A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00885
(DMRL_synthase) 		3 SER A  25
ALA A  78
VAL A  77
 TSF  A 701 (-3.1A)
None
None
 0.55A 5xiwC-2c94A:
undetectable		 5xiwC-2c94A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A 304
ALA A 307
VAL A 308
 None
 0.54A 5xiwC-2ep5A:
undetectable		 5xiwC-2ep5A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f58 PROTEIN (IGG1 FAB
58.2 ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.54A 5xiwC-2f58H:
undetectable		 5xiwC-2f58H:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.49A 5xiwC-2g60H:
undetectable		 5xiwC-2g60H:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjz CATALYTIC
ELIMINATION ANTIBODY
13G5 HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER H 216
ALA H 211
VAL H 210
 None
 0.54A 5xiwC-2gjzH:
undetectable		 5xiwC-2gjzH:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4s GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 3 SER A 289
ALA A 263
VAL A 262
 None
 0.55A 5xiwC-2i4sA:
undetectable		 5xiwC-2i4sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfi 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		3 SER A  22
ALA A  71
VAL A  70
 None
 0.55A 5xiwC-2mfiA:
undetectable		 5xiwC-2mfiA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpa MN12H2
IGG2A-KAPPA,HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 211
ALA H 206
VAL H 205
 None
 0.50A 5xiwC-2mpaH:
undetectable		 5xiwC-2mpaH:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok0 FAB ED10 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.52A 5xiwC-2ok0H:
undetectable		 5xiwC-2ok0H:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1y FAB, ANTIBODY
FRAGMENT (IGG1K),
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 201
ALA B 196
VAL B 195
 None
 0.53A 5xiwC-2r1yB:
undetectable		 5xiwC-2r1yB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.52A 5xiwC-2r4sH:
undetectable		 5xiwC-2r4sH:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.55A 5xiwC-2v9uA:
undetectable		 5xiwC-2v9uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		3 SER A 400
ALA A 398
VAL A 397
 None
 0.49A 5xiwC-2w9mA:
undetectable		 5xiwC-2w9mA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy A13-D6.3 MONOCLONAL
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER G 203
ALA G 198
VAL G 197
 None
 0.54A 5xiwC-2xqyG:
undetectable		 5xiwC-2xqyG:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 208
ALA B 203
VAL B 202
 None
 0.52A 5xiwC-2z4qB:
undetectable		 5xiwC-2z4qB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		3 SER A  89
ALA A 111
VAL A 110
 MLA  A4892 (-3.2A)
None
None
 0.55A 5xiwC-3bf8A:
1.9		 5xiwC-3bf8A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		3 SER A 852
ALA A 847
VAL A 846
 None
 0.52A 5xiwC-3dpuA:
undetectable		 5xiwC-3dpuA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		3 SER A 102
ALA A 129
VAL A 128
 SO4  A 255 (-2.2A)
None
None
 0.49A 5xiwC-3ds8A:
3.5		 5xiwC-3ds8A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		3 SER A  21
ALA A  72
VAL A  97
 RIB  A 305 ( 4.7A)
None
None
 0.53A 5xiwC-3go7A:
4.8		 5xiwC-3go7A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		3 SER A 245
ALA A 241
VAL A 240
 None
 0.43A 5xiwC-3hheA:
2.1		 5xiwC-3hheA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 SER A 142
ALA A 113
VAL A 112
 None
 0.51A 5xiwC-3k9dA:
undetectable		 5xiwC-3k9dA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mck C705 MONOCLONAL
HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER H 213
ALA H 208
VAL H 207
 None
 0.52A 5xiwC-3mckH:
undetectable		 5xiwC-3mckH:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbk PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		3 SER A 123
ALA A 117
VAL A 116
 None
 0.51A 5xiwC-3nbkA:
undetectable		 5xiwC-3nbkA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojd FAB V2D2

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 203
ALA B 198
VAL B 197
 None
 0.55A 5xiwC-3ojdB:
undetectable		 5xiwC-3ojdB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 HEAVY CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.50A 5xiwC-3r08H:
undetectable		 5xiwC-3r08H:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER F 212
ALA F 207
VAL F 206
 None
 0.54A 5xiwC-3riaF:
undetectable		 5xiwC-3riaF:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		3 SER A 130
ALA A 128
VAL A 127
 None
AMP  A 616 ( 3.8A)
None
 0.45A 5xiwC-3sgiA:
undetectable		 5xiwC-3sgiA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		3 SER A 173
ALA A 175
VAL A 176
 None
 0.39A 5xiwC-3vvlA:
1.8		 5xiwC-3vvlA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 3 SER B 162
ALA B 153
VAL B 152
 None
 0.47A 5xiwC-3x17B:
undetectable		 5xiwC-3x17B:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkm FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER C 206
ALA C 201
VAL C 200
 None
 0.53A 5xiwC-3zkmC:
undetectable		 5xiwC-3zkmC:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.51A 5xiwC-4ag4H:
undetectable		 5xiwC-4ag4H:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		3 SER A 431
ALA A 429
VAL A 423
 None
 0.49A 5xiwC-4bv6A:
1.9		 5xiwC-4bv6A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ISCR

(Escherichia
coli) 		PF02082
(Rrf2) 		3 SER A  73
ALA A  75
VAL A  76
 None
 0.49A 5xiwC-4chuA:
undetectable		 5xiwC-4chuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3c SFN68 FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER L  12
ALA L  14
VAL L  15
 None
 0.51A 5xiwC-4d3cL:
undetectable		 5xiwC-4d3cL:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edx HEAVY CHAIN OF FAB
OF MURINE ANTI-NGF

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.54A 5xiwC-4edxB:
undetectable		 5xiwC-4edxB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffz DENV1-E111 FAB
FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.52A 5xiwC-4ffzH:
undetectable		 5xiwC-4ffzH:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq9 CHIKUNGUNYA VIRUS
NEUTRALIZING
ANTIBODY 9.8B FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 208
ALA H 203
VAL H 202
 None
 0.50A 5xiwC-4gq9H:
undetectable		 5xiwC-4gq9H:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		3 SER A 148
ALA A 145
VAL A 144
 None
 0.39A 5xiwC-4guzA:
undetectable		 5xiwC-4guzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf0 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ISCR

(Escherichia
coli) 		PF02082
(Rrf2) 		3 SER A  73
ALA A  75
VAL A  76
 None
 0.50A 5xiwC-4hf0A:
undetectable		 5xiwC-4hf0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		3 SER A  76
ALA A  78
VAL A  79
 None
 0.54A 5xiwC-4ho4A:
undetectable		 5xiwC-4ho4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.52A 5xiwC-4k3eH:
undetectable		 5xiwC-4k3eH:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5f HEAVY CHAIN OF E106
ANTIBODY (VH AND CH1
OF IGG2C)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 198
VAL H 197
 None
 0.54A 5xiwC-4l5fH:
undetectable		 5xiwC-4l5fH:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m43 FRAGMENT
ANTIGEN-BINDING
523-11 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.51A 5xiwC-4m43H:
undetectable		 5xiwC-4m43H:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 3 SER B  44
ALA B  22
VAL B  21
 SO4  B 301 (-3.2A)
None
None
 0.50A 5xiwC-4mkiB:
undetectable		 5xiwC-4mkiB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8c HEAVY CHAIN OF
MONOCLONAL ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 209
ALA H 204
VAL H 203
 None
 0.52A 5xiwC-4n8cH:
undetectable		 5xiwC-4n8cH:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncc FAB FRAGMENT HEAVY

(Mus musculus) 		no annotation 3 SER H 209
ALA H 204
VAL H 203
 None
 0.54A 5xiwC-4nccH:
undetectable		 5xiwC-4nccH:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 202
ALA H 197
VAL H 196
 None
 0.51A 5xiwC-4qexH:
undetectable		 5xiwC-4qexH:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0n PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		3 SER A 123
ALA A 117
VAL A 116
 None
 0.43A 5xiwC-4r0nA:
undetectable		 5xiwC-4r0nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1g QA1 MONOCLONAL
ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 212
ALA B 207
VAL B 206
 None
 0.54A 5xiwC-4u1gB:
undetectable		 5xiwC-4u1gB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		3 SER B 148
ALA B 150
VAL B 151
 None
 0.52A 5xiwC-4xl1B:
undetectable		 5xiwC-4xl1B:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlw DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		3 SER B 148
ALA B 150
VAL B 151
 None
 0.52A 5xiwC-4xlwB:
undetectable		 5xiwC-4xlwB:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 211
ALA H 206
VAL H 205
 None
 0.51A 5xiwC-4z0bH:
undetectable		 5xiwC-4z0bH:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb FAB 83-7 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 208
ALA A 203
VAL A 202
 None
 0.52A 5xiwC-4zxbA:
undetectable		 5xiwC-4zxbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5any FAB CHK265

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER I 203
ALA I 198
VAL I 197
 None
 0.54A 5xiwC-5anyI:
undetectable		 5xiwC-5anyI:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 3 SER H 210
ALA H 205
VAL H 204
 None
 0.54A 5xiwC-5c0nH:
undetectable		 5xiwC-5c0nH:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 SER A  78
ALA A 121
VAL A 120
 None
 0.50A 5xiwC-5c70A:
2.6		 5xiwC-5c70A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en2 GD01 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 203
ALA A 198
VAL A 197
 None
 0.55A 5xiwC-5en2A:
undetectable		 5xiwC-5en2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 206
ALA H 201
VAL H 200
 None
 0.53A 5xiwC-5eorH:
undetectable		 5xiwC-5eorH:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 SER A  20
ALA A  22
VAL A  23
 None
 0.53A 5xiwC-5h1kA:
undetectable		 5xiwC-5h1kA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdb MONOCLONAL ANTIBODY
10E5 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER E 209
ALA E 204
VAL E 203
 None
 0.52A 5xiwC-5hdbE:
undetectable		 5xiwC-5hdbE:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 SER A 533
ALA A 531
VAL A 530
 None
 0.54A 5xiwC-5i2tA:
undetectable		 5xiwC-5i2tA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i73 8B6 ANTIBODY, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 228
ALA B 223
VAL B 222
 None
 0.47A 5xiwC-5i73B:
undetectable		 5xiwC-5i73B:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 SER A 169
ALA A 171
VAL A 172
 None
None
TRH  A 500 (-3.9A)
 0.53A 5xiwC-5ifyA:
undetectable		 5xiwC-5ifyA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		3 SER A  97
ALA A  95
VAL A  94
 None
 0.53A 5xiwC-5inrA:
undetectable		 5xiwC-5inrA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy2 BETA-LACTAMASE
OXA-143

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 SER A 247
ALA A 245
VAL A 244
 None
 0.50A 5xiwC-5iy2A:
undetectable		 5xiwC-5iy2A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		3 SER A 164
ALA A 135
VAL A 134
 None
 0.55A 5xiwC-5j78A:
undetectable		 5xiwC-5j78A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0q MAB 8C7 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER C 210
ALA C 205
VAL C 204
 None
 0.52A 5xiwC-5l0qC:
undetectable		 5xiwC-5l0qC:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lji FLAVODOXIN

(Streptococcus
pneumoniae) 		PF00258
(Flavodoxin_1) 		3 SER A  90
ALA A  55
VAL A  54
 FMN  A 201 (-2.8A)
None
None
 0.55A 5xiwC-5ljiA:
3.5		 5xiwC-5ljiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 MONOCLONAL ANTIBODY
9AD4

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 212
ALA B 207
VAL B 206
 None
 0.50A 5xiwC-5mi0B:
undetectable		 5xiwC-5mi0B:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhy ZV67 FAB CHAIN 2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.52A 5xiwC-5uhyH:
undetectable		 5xiwC-5uhyH:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtg FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 211
ALA B 206
VAL B 205
 None
 0.49A 5xiwC-5wtgB:
undetectable		 5xiwC-5wtgB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 3 SER A 141
ALA A 143
VAL A 144
 None
None
GOL  A1003 (-4.8A)
 0.54A 5xiwC-5y0mA:
undetectable		 5xiwC-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER H 204
ALA H 199
VAL H 198
 None
 0.52A 5xiwC-6aq7H:
undetectable		 5xiwC-6aq7H:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzy 22D11 HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER H 204
ALA H 199
VAL H 198
 None
 0.52A 5xiwC-6bzyH:
undetectable		 5xiwC-6bzyH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER G 210
ALA G 205
VAL G 204
 None
 0.55A 5xiwC-6cnkG:
undetectable		 5xiwC-6cnkG:
17.44