SIMILAR PATTERNS OF AMINO ACIDS FOR 5XIQ_D_HFGD1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		3 THR A 268
GLU A 270
HIS A  69
 None
 0.88A 5xiqD-1arlA:
undetectable		 5xiqD-1arlA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		3 THR A 219
GLU A 129
HIS A  98
 None
 0.89A 5xiqD-1egzA:
undetectable		 5xiqD-1egzA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 THR A 177
GLU A 316
HIS A  65
 NAD  A 375 (-3.6A)
NAD  A 375 ( 4.3A)
ZN  A 372 (-3.4A)
 0.69A 5xiqD-1f8fA:
2.2		 5xiqD-1f8fA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		3 THR A 171
GLU A 166
HIS A  93
 None
 0.84A 5xiqD-1gzjA:
undetectable		 5xiqD-1gzjA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc4 METHYLMALONYL-COA
EPIMERASE

(Propionibacterium
freudenreichii) 		PF13669
(Glyoxalase_4) 		3 THR A 122
GLU A  48
HIS A  91
 SO4  A 203 (-3.0A)
SO4  A 203 (-3.6A)
None
 0.89A 5xiqD-1jc4A:
undetectable		 5xiqD-1jc4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A  91
GLU A  47
HIS A 143
 None
None
CU  A 501 (-3.1A)
 0.90A 5xiqD-1kbvA:
undetectable		 5xiqD-1kbvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		3 THR A  68
GLU A 208
HIS A 206
 CYS  A1000 (-3.3A)
CYS  A1000 ( 4.9A)
None
 0.90A 5xiqD-1li7A:
2.2		 5xiqD-1li7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		3 THR A  87
GLU A 239
HIS A 232
 None
 0.91A 5xiqD-1m54A:
undetectable		 5xiqD-1m54A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 THR A 264
GLU A 126
HIS A 123
 None
 0.74A 5xiqD-1m7sA:
undetectable		 5xiqD-1m7sA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A 117
GLU A 119
HIS A 237
 5CA  A 512 (-3.5A)
5CA  A 512 (-3.0A)
5CA  A 512 (-4.4A)
 0.45A 5xiqD-1nj1A:
43.8		 5xiqD-1nj1A:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		3 THR A 101
GLU A 103
HIS A 221
 None
 0.74A 5xiqD-1nj8A:
42.3		 5xiqD-1nj8A:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 THR A 274
GLU A 196
HIS A 336
 None
 0.81A 5xiqD-1o2dA:
undetectable		 5xiqD-1o2dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 THR A 255
GLU A 282
HIS A  51
 None
 0.84A 5xiqD-1q1nA:
2.8		 5xiqD-1q1nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		3 THR A  71
GLU A 104
HIS A 132
 None
 0.81A 5xiqD-1sfjA:
undetectable		 5xiqD-1sfjA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		3 THR A 221
GLU A 131
HIS A 100
 None
 0.90A 5xiqD-1tvpA:
undetectable		 5xiqD-1tvpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve0 HYPOTHETICAL PROTEIN
(ST2072)

(Sulfurisphaera
tokodaii) 		PF01894
(UPF0047) 		3 THR A  12
GLU A 118
HIS A  43
 None
None
SO4  A 135 (-4.1A)
 0.93A 5xiqD-1ve0A:
undetectable		 5xiqD-1ve0A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmf HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01894
(UPF0047) 		3 THR A   8
GLU A 116
HIS A  41
 None
None
ACT  A 135 (-4.1A)
 0.87A 5xiqD-1vmfA:
undetectable		 5xiqD-1vmfA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01128
(IspD) 		3 THR A  78
GLU A 175
HIS A 170
 None
 0.84A 5xiqD-1vpaA:
2.9		 5xiqD-1vpaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vph HYPOTHETICAL PROTEIN
SSO2532

(Sulfolobus
solfataricus) 		PF01894
(UPF0047) 		3 THR A  12
GLU A 120
HIS A  45
 None
None
PO4  A 139 (-3.9A)
 0.89A 5xiqD-1vphA:
undetectable		 5xiqD-1vphA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A  92
GLU A  47
HIS A  60
 None
 0.88A 5xiqD-2avfA:
undetectable		 5xiqD-2avfA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		3 THR A 234
GLU A 232
HIS A 141
 None
None
ZN  A 401 (-3.4A)
 0.77A 5xiqD-2cbnA:
undetectable		 5xiqD-2cbnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A 123
GLU A  79
HIS A 177
 None
None
CU  A 401 (-3.1A)
 0.88A 5xiqD-2dwsA:
undetectable		 5xiqD-2dwsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		3 THR A 210
GLU A 208
HIS A 134
 None
None
ZN  A1302 (-3.7A)
 0.79A 5xiqD-2e7yA:
undetectable		 5xiqD-2e7yA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 148
GLU A 506
HIS A 446
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-4.0A)
 0.74A 5xiqD-2fqdA:
undetectable		 5xiqD-2fqdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 148
GLU A 506
HIS A 448
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.3A)
 0.74A 5xiqD-2fqdA:
undetectable		 5xiqD-2fqdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.87A 5xiqD-2i7tA:
undetectable		 5xiqD-2i7tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.89A 5xiqD-2iyaA:
3.1		 5xiqD-2iyaA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6h HYPOTHETICAL PROTEIN

(Aeropyrum
pernix) 		PF01894
(UPF0047) 		3 THR A  10
GLU A 118
HIS A  43
 None
None
SO4  A 501 (-4.4A)
 0.92A 5xiqD-2p6hA:
undetectable		 5xiqD-2p6hA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6y HYPOTHETICAL PROTEIN
VCA0587

(Vibrio cholerae) 		PF03479
(DUF296) 		3 THR A 122
GLU A 126
HIS A  75
 None
None
ZN  A 201 (-3.3A)
 0.91A 5xiqD-2p6yA:
undetectable		 5xiqD-2p6yA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		3 THR A  68
GLU A 104
HIS A 103
 NAD  A 358 ( 4.7A)
None
None
 0.86A 5xiqD-2q1tA:
undetectable		 5xiqD-2q1tA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		3 THR A 140
GLU A 388
HIS A 364
 TRS  A1478 ( 4.4A)
TRS  A1478 (-2.8A)
UDP  A1477 (-3.9A)
 0.87A 5xiqD-2vg8A:
2.2		 5xiqD-2vg8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 THR A  68
GLU A  38
HIS A 221
 None
None
FE2  A 401 ( 3.4A)
 0.77A 5xiqD-2vw8A:
undetectable		 5xiqD-2vw8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		3 THR A  68
GLU A  42
HIS A  38
 CD  A1559 (-3.5A)
CD  A1559 (-3.0A)
CD  A1560 ( 3.5A)
 0.89A 5xiqD-2w5fA:
undetectable		 5xiqD-2w5fA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 (-3.5A)
 0.90A 5xiqD-2xr1A:
undetectable		 5xiqD-2xr1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		3 THR A 268
GLU A 270
HIS A 247
 None
 0.86A 5xiqD-2xrcA:
undetectable		 5xiqD-2xrcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 ( 3.3A)
 0.75A 5xiqD-2ycbA:
undetectable		 5xiqD-2ycbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A 394
GLU A 392
HIS A 344
 None
None
ZN  A 662 (-3.4A)
 0.82A 5xiqD-3af5A:
undetectable		 5xiqD-3af5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 139
GLU A 466
HIS A 396
 None
C2O  A 702 ( 4.5A)
C2O  A 702 ( 3.3A)
 0.88A 5xiqD-3aw5A:
undetectable		 5xiqD-3aw5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 THR A 220
GLU A 125
HIS A 111
 None
MG  A 901 ( 4.4A)
MG  A 901 (-3.4A)
 0.84A 5xiqD-3fe4A:
undetectable		 5xiqD-3fe4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 THR A 385
GLU A 481
HIS A 480
 None
 0.88A 5xiqD-3gszA:
undetectable		 5xiqD-3gszA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 208
GLU A 609
HIS A 529
 None
C2O  A1002 ( 4.8A)
CU  A1004 ( 3.2A)
 0.90A 5xiqD-3gyrA:
undetectable		 5xiqD-3gyrA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A  92
GLU A  47
HIS A  60
 None
 0.91A 5xiqD-3h4hA:
undetectable		 5xiqD-3h4hA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A  92
GLU A  47
HIS A 145
 None
None
CU  A1501 (-3.0A)
 0.93A 5xiqD-3h4hA:
undetectable		 5xiqD-3h4hA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A 146
GLU A 148
HIS A 266
 PR8  A 601 (-4.0A)
PR8  A 601 (-3.0A)
PR8  A 601 ( 3.9A)
 0.32A 5xiqD-3ialA:
43.2		 5xiqD-3ialA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 THR A 188
GLU A 186
HIS A 141
 U  E   1 ( 4.9A)
None
ZN  A 453 (-3.3A)
 0.82A 5xiqD-3ie1A:
undetectable		 5xiqD-3ie1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 3 THR B 636
GLU B 541
HIS B 587
 None
 0.76A 5xiqD-3kx2B:
undetectable		 5xiqD-3kx2B:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		3 THR A  33
GLU A 342
HIS A 328
 None
None
MN  A 396 (-3.3A)
 0.91A 5xiqD-3m8yA:
undetectable		 5xiqD-3m8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		3 THR A 323
GLU A 309
HIS A 294
 GOL  A 417 (-4.1A)
None
None
 0.72A 5xiqD-3s9jA:
undetectable		 5xiqD-3s9jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 THR A  67
GLU A 220
HIS A 218
 None
 0.87A 5xiqD-3sp1A:
undetectable		 5xiqD-3sp1A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 THR A 306
GLU A 387
HIS A 453
 None
 0.88A 5xiqD-3u3iA:
undetectable		 5xiqD-3u3iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		3 THR A 121
GLU A 124
HIS A 183
 None
None
SO4  A 904 ( 3.8A)
 0.73A 5xiqD-3vmwA:
undetectable		 5xiqD-3vmwA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		3 THR A  97
GLU A 241
HIS A 234
 None
 0.92A 5xiqD-3vscA:
2.6		 5xiqD-3vscA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 THR A  98
GLU A  91
HIS A 236
 None
 0.76A 5xiqD-3vueA:
2.1		 5xiqD-3vueA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		3 THR A  14
GLU A 159
HIS A 152
 None
None
PLP  A 401 ( 4.9A)
 0.91A 5xiqD-3x43A:
undetectable		 5xiqD-3x43A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		3 THR A  14
GLU A 161
HIS A 154
 None
 0.90A 5xiqD-3zeiA:
undetectable		 5xiqD-3zeiA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		3 THR A 277
GLU A 275
HIS A 182
 None
None
ZN  A1364 ( 3.5A)
 0.82A 5xiqD-3zwfA:
undetectable		 5xiqD-3zwfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 3 THR A 180
GLU A 340
HIS A  44
 None
 0.84A 5xiqD-4bpsA:
undetectable		 5xiqD-4bpsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF05207
(zf-CSL) 		3 THR A 230
GLU A 271
HIS A 250
 None
 0.83A 5xiqD-4d4pA:
undetectable		 5xiqD-4d4pA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		3 THR A 127
GLU A 209
HIS A 136
 None
 0.93A 5xiqD-4glfA:
undetectable		 5xiqD-4glfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 THR A 288
GLU A 189
HIS A 146
 None
None
CTT  A 401 (-3.7A)
 0.85A 5xiqD-4hu0A:
undetectable		 5xiqD-4hu0A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		3 THR A  96
GLU A  13
HIS A  34
 None
None
PO4  A 400 (-3.9A)
 0.66A 5xiqD-4hwgA:
2.4		 5xiqD-4hwgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		3 THR A  24
GLU A 175
HIS A 169
 None
 0.91A 5xiqD-4il5A:
undetectable		 5xiqD-4il5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 THR A 503
GLU A 499
HIS A 428
 None
 0.70A 5xiqD-4ktpA:
undetectable		 5xiqD-4ktpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		3 THR X  14
GLU X 160
HIS X 153
 None
 0.90A 5xiqD-4li3X:
undetectable		 5xiqD-4li3X:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		3 THR A  38
GLU A 354
HIS A 340
 None
None
MN  A 501 (-3.2A)
 0.88A 5xiqD-4n7tA:
undetectable		 5xiqD-4n7tA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 THR A 361
GLU A 236
HIS A 194
 None
 0.82A 5xiqD-4w87A:
undetectable		 5xiqD-4w87A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		3 THR B 230
GLU B 271
HIS B 250
 None
None
CL  A 102 ( 4.8A)
 0.86A 5xiqD-4x33B:
undetectable		 5xiqD-4x33B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(uncultured
bacterium;
Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 THR A 229
GLU A 138
HIS A 104
 None
 0.91A 5xiqD-4xzwA:
undetectable		 5xiqD-4xzwA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A 359
GLU A 361
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 (-4.0A)
 0.16A 5xiqD-4ydqA:
52.7		 5xiqD-4ydqA:
65.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		3 THR A 333
GLU A 449
HIS A 442
 None
 0.83A 5xiqD-4ye9A:
undetectable		 5xiqD-4ye9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		3 THR A 290
GLU A 185
HIS A 142
 None
None
BGC  A1367 (-4.0A)
 0.90A 5xiqD-5a8qA:
undetectable		 5xiqD-5a8qA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7j SWITCH-ACTIVATING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 3 THR A  30
GLU A  36
HIS A  76
 None
 0.75A 5xiqD-5b7jA:
undetectable		 5xiqD-5b7jA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		3 THR A 152
GLU A 409
HIS A 408
 None
 0.84A 5xiqD-5e78A:
undetectable		 5xiqD-5e78A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 THR A 284
GLU A 184
HIS A 149
 None
 0.85A 5xiqD-5ecuA:
undetectable		 5xiqD-5ecuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 THR A 293
GLU A 188
HIS A 153
 None
 0.92A 5xiqD-5fipA:
undetectable		 5xiqD-5fipA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		3 THR A 208
GLU A 206
HIS A 152
 A  C   1 ( 4.4A)
None
None
 0.76A 5xiqD-5habA:
undetectable		 5xiqD-5habA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		3 THR A 198
GLU A 193
HIS A 120
 None
 0.82A 5xiqD-5i77A:
undetectable		 5xiqD-5i77A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		3 THR A 246
GLU A 155
HIS A 124
 None
 0.89A 5xiqD-5ihsA:
undetectable		 5xiqD-5ihsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		3 THR A 173
GLU A 108
HIS A 146
 None
None
BEZ  A 401 ( 4.2A)
 0.88A 5xiqD-5im2A:
undetectable		 5xiqD-5im2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		3 THR A 338
GLU A 210
HIS A 131
 None
None
BGC  A 604 (-4.5A)
 0.92A 5xiqD-5j7zA:
undetectable		 5xiqD-5j7zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 THR A 297
GLU A 278
HIS A 166
 None
 0.92A 5xiqD-5mp7A:
undetectable		 5xiqD-5mp7A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Aspergillus
fumigatus) 		PF01487
(DHquinase_I) 		3 THR A1122
GLU A1155
HIS A1179
 None
 0.57A 5xiqD-5swuA:
undetectable		 5xiqD-5swuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 THR A 180
GLU A 319
HIS A  68
 None
 0.76A 5xiqD-5tnxA:
2.1		 5xiqD-5tnxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		3 THR A 131
GLU A 293
HIS A 289
 None
 0.71A 5xiqD-5uibA:
2.2		 5xiqD-5uibA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A1121
GLU A1123
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 (-4.1A)
 0.52A 5xiqD-5vadA:
49.6		 5xiqD-5vadA:
55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 3 THR A 283
GLU A 192
HIS A 156
 None
 0.89A 5xiqD-5wh8A:
undetectable		 5xiqD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		3 THR A  14
GLU A 160
HIS A 153
 None
 0.91A 5xiqD-5xa2A:
undetectable		 5xiqD-5xa2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 3 THR A 439
GLU A 441
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.7A)
 0.10A 5xiqD-5xiiA:
56.3		 5xiqD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 3 THR A 331
GLU A 333
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
HFG  A 801 (-4.2A)
 0.11A 5xiqD-5xioA:
51.5		 5xiqD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 3 THR A 359
GLU A 361
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 (-3.5A)
 0.27A 5xiqD-5xipA:
53.0		 5xiqD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 THR B 493
GLU B 207
HIS B 511
 None
 0.80A 5xiqD-5xogB:
undetectable		 5xiqD-5xogB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybl MULTIFUNCTIONAL
DIOXYGENASE AUSE

(Aspergillus
nidulans) 		no annotation 3 THR A 260
GLU A  89
HIS A  85
 None
 0.91A 5xiqD-5yblA:
undetectable		 5xiqD-5yblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN

(Japanese
encephalitis
virus) 		no annotation 3 THR A 317
GLU A 373
HIS A 144
 None
 0.62A 5xiqD-5ywpA:
undetectable		 5xiqD-5ywpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk8 PRE-MRNA-SPLICING
FACTOR SYF1

(Saccharomyces
cerevisiae) 		no annotation 3 THR U 796
GLU U 788
HIS U 791
 None
 0.89A 5xiqD-6bk8U:
undetectable		 5xiqD-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 3 THR A  21
GLU A 174
HIS A 167
 None
 0.93A 5xiqD-6c2hA:
2.6		 5xiqD-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 THR A 138
GLU A 496
HIS A 437
 None
 0.74A 5xiqD-6evgA:
undetectable		 5xiqD-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 THR A 138
GLU A 496
HIS A 439
 None
None
EDO  A 602 (-3.8A)
 0.80A 5xiqD-6evgA:
undetectable		 5xiqD-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 THR A 138
GLU A 496
HIS A 491
 None
 0.93A 5xiqD-6evgA:
undetectable		 5xiqD-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 3 THR A  17
GLU A  10
HIS A 153
 QPS  A 602 (-3.2A)
QPS  A 602 ( 4.5A)
QPS  A 602 (-3.9A)
 0.90A 5xiqD-6gnfA:
3.0		 5xiqD-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 3 THR A  35
GLU A  28
HIS A 171
 QPS  A 601 ( 3.0A)
QPS  A 601 ( 4.1A)
QPS  A 601 (-4.2A)
 0.91A 5xiqD-6gngA:
3.4		 5xiqD-6gngA:
undetectable