SIMILAR PATTERNS OF AMINO ACIDS FOR 5XIP_D_HFGD1003_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 GLU A 369
VAL A 368
PRO A 279
THR A 280
THR A 286
 None
 1.27A 5xipD-1cg4A:
undetectable		 5xipD-1cg4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		5 LEU B 133
VAL B 137
PRO B 158
THR B 157
ARG B 160
 None
 1.29A 5xipD-1d2zB:
undetectable		 5xipD-1d2zB:
15.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLU A  90
ARG A 142
TRP A 158
THR A 228
TRP A 259
 None
 1.15A 5xipD-1hc7A:
46.9		 5xipD-1hc7A:
44.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 LEU A  77
PRO A 110
THR A 111
ARG A 142
TRP A 158
GLU A 160
PHE A 205
THR A 228
TRP A 259
 None
 0.71A 5xipD-1hc7A:
46.9		 5xipD-1hc7A:
44.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		8 LEU A  77
THR A 111
GLU A 113
TRP A 158
GLU A 160
PHE A 205
THR A 228
TRP A 259
 None
 0.92A 5xipD-1hc7A:
46.9		 5xipD-1hc7A:
44.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 LEU A  91
GLU A 144
TRP A 158
GLU A 160
THR A 228
TRP A 259
 None
 1.28A 5xipD-1hc7A:
46.9		 5xipD-1hc7A:
44.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLU A 150
GLU A 119
ARG A 148
GLU A 168
PHE A 212
 5CA  A 512 (-4.1A)
5CA  A 512 (-3.0A)
5CA  A 512 (-2.9A)
None
5CA  A 512 (-4.0A)
 1.16A 5xipD-1nj1A:
43.5		 5xipD-1nj1A:
34.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 GLU A 150
PRO A 116
THR A 117
GLU A 119
ARG A 148
GLU A 168
 5CA  A 512 (-4.1A)
None
5CA  A 512 (-3.5A)
5CA  A 512 (-3.0A)
5CA  A 512 (-2.9A)
None
 0.94A 5xipD-1nj1A:
43.5		 5xipD-1nj1A:
34.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 LEU A  83
GLU A  96
VAL A  97
PRO A 116
THR A 117
GLU A 119
ARG A 148
GLU A 168
THR A 235
 None
None
None
None
5CA  A 512 (-3.5A)
5CA  A 512 (-3.0A)
5CA  A 512 (-2.9A)
None
5CA  A 512 (-3.0A)
 0.70A 5xipD-1nj1A:
43.5		 5xipD-1nj1A:
34.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 LEU A  83
GLU A  96
VAL A  97
PRO A 116
THR A 117
GLU A 119
THR A 218
 None
None
None
None
5CA  A 512 (-3.5A)
5CA  A 512 (-3.0A)
None
 1.20A 5xipD-1nj1A:
43.5		 5xipD-1nj1A:
34.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 LEU A  83
VAL A  97
GLU A 119
ARG A 148
GLU A 168
PHE A 212
THR A 235
 None
None
5CA  A 512 (-3.0A)
5CA  A 512 (-2.9A)
None
5CA  A 512 (-4.0A)
5CA  A 512 (-3.0A)
 0.86A 5xipD-1nj1A:
43.5		 5xipD-1nj1A:
34.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 VAL A  97
PRO A 116
THR A 117
GLU A 168
PHE A 243
 None
None
5CA  A 512 (-3.5A)
None
None
 1.19A 5xipD-1nj1A:
43.5		 5xipD-1nj1A:
34.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		6 GLU A  80
VAL A  81
PRO A 100
GLU A 103
PHE A 196
THR A 219
 None
 1.26A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 LEU A  67
VAL A  81
PRO A 100
ARG A 132
PHE A 196
 None
 1.46A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		7 LEU A  67
VAL A  81
PRO A 100
THR A 101
GLU A 103
GLU A 152
THR A 219
 None
 0.70A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		7 LEU A  67
VAL A  81
PRO A 100
THR A 101
GLU A 103
PHE A 196
THR A 219
 None
 1.06A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 VAL A  81
PRO A 100
THR A 101
GLU A 152
PHE A 227
 None
 1.12A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01128
(IspD) 		5 LEU A  99
VAL A 113
PRO A 158
THR A 157
THR A 203
 None
None
None
None
CTP  A 500 ( 4.6A)
 1.28A 5xipD-1vpaA:
3.5		 5xipD-1vpaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3a GLUTAMINE SYNTHETASE

(Zea mays) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.07A 5xipD-2d3aA:
undetectable		 5xipD-2d3aA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 LEU A 205
PRO A 230
THR A 231
GLU A 233
ARG A 262
 None
None
SSA  A1001 (-3.2A)
SSA  A1001 (-3.7A)
SSA  A1001 (-2.8A)
 1.05A 5xipD-2dq3A:
22.0		 5xipD-2dq3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 GLU A  92
PRO A 108
THR A 109
GLU A 111
ARG A 140
 None
None
5CA  A 439 (-3.6A)
5CA  A 439 (-2.6A)
5CA  A 439 (-2.8A)
 0.42A 5xipD-2i4nA:
28.7		 5xipD-2i4nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 PRO A  17
THR A  16
GLU A  40
GLU A 164
THR A 185
 None
None
None
None
PLP  A 400 (-3.6A)
 1.14A 5xipD-2isqA:
undetectable		 5xipD-2isqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 LEU A  56
GLU A 340
VAL A 339
THR A 333
ARG A 337
 None
 1.42A 5xipD-2iuyA:
2.4		 5xipD-2iuyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		5 GLU A 142
PRO A 108
THR A 109
GLU A 111
ARG A 140
 ATP  A 701 (-3.4A)
None
PRI  A1566 (-3.4A)
PRI  A1566 (-3.4A)
ATP  A 701 ( 2.6A)
 1.42A 5xipD-2j3mA:
25.0		 5xipD-2j3mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 145
VAL A 199
PRO A 138
THR A 139
GLU A 126
 LEU  A 145 ( 0.6A)
VAL  A 199 ( 0.6A)
PRO  A 138 ( 1.1A)
THR  A 139 ( 0.8A)
GLU  A 126 ( 0.5A)
 1.39A 5xipD-2nvvA:
undetectable		 5xipD-2nvvA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 291
GLU A 315
VAL A 314
GLU A 282
ARG A 312
 None
 1.40A 5xipD-2p6rA:
undetectable		 5xipD-2p6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		5 LEU A  32
VAL A  36
PRO A 227
THR A 226
GLU A 290
 None
None
None
ZN  A 501 ( 4.9A)
ZN  A 501 (-2.6A)
 1.38A 5xipD-2rjbA:
undetectable		 5xipD-2rjbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		5 LEU C 238
GLU C 297
PRO C 215
GLU C 145
THR C  20
 None
None
None
None
PMR  C1414 (-3.9A)
 1.47A 5xipD-2ynmC:
undetectable		 5xipD-2ynmC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		5 LEU A 208
GLU A 174
VAL A 175
THR A 136
GLU A 144
 None
PO4  A 403 ( 3.3A)
None
None
None
 1.38A 5xipD-3bacA:
undetectable		 5xipD-3bacA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhg ADENYLOSUCCINATE
LYASE

(Legionella
pneumophila) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 167
VAL A 384
PRO A 177
THR A 178
GLU A 183
 None
 1.33A 5xipD-3bhgA:
undetectable		 5xipD-3bhgA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 LEU A 265
VAL A 310
PRO A 260
THR A 237
GLU A 214
 None
 1.31A 5xipD-3dc8A:
undetectable		 5xipD-3dc8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		5 VAL A 418
PRO A 378
GLU A 392
ARG A 377
THR A 311
 None
None
None
HMH  A1001 (-4.6A)
None
 1.43A 5xipD-3epmA:
undetectable		 5xipD-3epmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 LEU A  39
GLU A 318
VAL A 316
THR A 310
ARG A 314
 None
 1.11A 5xipD-3f8rA:
undetectable		 5xipD-3f8rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum) 		PF01764
(Lipase_3) 		5 LEU A 133
VAL A  99
PRO A 102
THR A  43
ARG A 101
 None
 1.23A 5xipD-3g7nA:
undetectable		 5xipD-3g7nA:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 LEU A 112
GLU A 125
GLU A 148
ARG A 177
GLU A 196
PHE A 241
 None
None
PR8  A 601 (-3.0A)
PR8  A 601 ( 4.3A)
PR8  A 601 (-4.5A)
PR8  A 601 ( 4.1A)
 0.92A 5xipD-3ialA:
42.4		 5xipD-3ialA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		8 LEU A 112
GLU A 125
PRO A 145
THR A 146
GLU A 148
ARG A 177
TRP A 194
GLU A 196
 None
None
None
PR8  A 601 (-4.0A)
PR8  A 601 (-3.0A)
PR8  A 601 ( 4.3A)
None
PR8  A 601 (-4.5A)
 0.56A 5xipD-3ialA:
42.4		 5xipD-3ialA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLU A 228
VAL A 226
THR A 194
ARG A 198
GLU A 152
 None
 1.11A 5xipD-3l06A:
2.2		 5xipD-3l06A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU B 913
VAL B 915
PRO B 886
PHE B1471
THR B1478
 None
 1.38A 5xipD-3prxB:
undetectable		 5xipD-3prxB:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		5 VAL A 148
PRO A 151
THR A 152
GLU A 109
THR A  29
 None
 1.09A 5xipD-3q6tA:
undetectable		 5xipD-3q6tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		5 VAL A 148
PRO A 151
THR A 152
GLU A 109
THR A  54
 None
 1.42A 5xipD-3q6tA:
undetectable		 5xipD-3q6tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		5 LEU A 218
GLU A 184
VAL A 185
THR A 143
GLU A 151
 None
AMP  A 616 (-3.7A)
None
None
None
 1.23A 5xipD-3sgiA:
undetectable		 5xipD-3sgiA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtd UNCHARACTERIZED
PROTEIN C9ORF142

(Homo sapiens) 		PF15384
(PAXX) 		5 LEU A  98
GLU A  81
THR A  73
ARG A  77
GLU A  27
 None
 1.30A 5xipD-3wtdA:
undetectable		 5xipD-3wtdA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 PRO A 125
THR A 124
GLU A 148
GLU A 272
THR A 293
 None
None
None
None
PLP  A 500 (-3.6A)
 1.18A 5xipD-4aecA:
undetectable		 5xipD-4aecA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 421
GLU A 416
VAL A 414
THR A 408
ARG A 412
 None
 1.41A 5xipD-4autA:
undetectable		 5xipD-4autA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN

(Escherichia
coli) 		PF05171
(HemS) 		5 LEU A 198
GLU A 183
VAL A 182
GLU A 302
TRP A 328
 EDO  A1338 (-4.3A)
None
None
HEM  A 402 ( 4.7A)
None
 1.32A 5xipD-4cdpA:
undetectable		 5xipD-4cdpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLU A 402
VAL A 399
PRO A 191
THR A 192
GLU A 197
 None
 1.27A 5xipD-4efcA:
undetectable		 5xipD-4efcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 181
GLU A 402
VAL A 399
PRO A 191
GLU A 197
 None
 1.43A 5xipD-4efcA:
undetectable		 5xipD-4efcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 LEU A 263
VAL A 275
THR A 311
PHE A 448
THR A 451
 None
None
SO4  A1003 ( 4.4A)
None
None
 1.47A 5xipD-4ifqA:
undetectable		 5xipD-4ifqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 229
VAL A 311
THR A 245
GLU A 250
ARG A 325
 None
 1.19A 5xipD-4kbfA:
undetectable		 5xipD-4kbfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLU A 413
VAL A 410
PRO A 202
THR A 203
GLU A 208
 None
 1.27A 5xipD-4mx2A:
undetectable		 5xipD-4mx2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 192
GLU A 413
VAL A 410
PRO A 202
GLU A 208
 None
 1.46A 5xipD-4mx2A:
undetectable		 5xipD-4mx2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 109
VAL A  65
PRO A  93
THR A  92
GLU A 118
 None
 1.40A 5xipD-4o1oA:
undetectable		 5xipD-4o1oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 LEU B 414
GLU B 446
VAL B 445
ARG B 443
GLU B 436
 None
 1.16A 5xipD-4peqB:
undetectable		 5xipD-4peqB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A 485
VAL A 491
PRO A 442
GLU A 155
THR A 462
 None
None
None
None
MAN  A 602 ( 3.3A)
 1.36A 5xipD-4pfwA:
undetectable		 5xipD-4pfwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qid BACTERIORHODOPSIN-I

(Haloquadratum
walsbyi) 		PF01036
(Bac_rhodopsin) 		5 LEU A  78
GLU A  75
VAL A  76
THR A 201
GLU A 212
 None
None
ACT  A 302 ( 4.5A)
None
None
 1.42A 5xipD-4qidA:
undetectable		 5xipD-4qidA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 GLU A 392
THR A 359
GLU A 361
ARG A 390
GLU A 409
TRP A 509
 ANP  A 801 (-3.6A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
None
 1.40A 5xipD-4ydqA:
50.6		 5xipD-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
GLU A 409
PHE A 454
THR A 478
TRP A 509
 None
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 ( 4.9A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
None
 0.61A 5xipD-4ydqA:
50.6		 5xipD-4ydqA:
63.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 VAL A 339
PRO A 358
THR A 359
GLU A 409
PHE A 486
TRP A 509
 HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
HFG  A 802 (-3.2A)
HFG  A 802 ( 4.9A)
None
None
 1.34A 5xipD-4ydqA:
50.6		 5xipD-4ydqA:
63.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermoproteus
uzoniensis) 		PF01063
(Aminotran_4) 		5 GLU A 184
VAL A 182
PRO A 201
THR A 200
THR A 215
 PLP  A 301 (-2.7A)
None
None
None
None
 1.47A 5xipD-5ce8A:
undetectable		 5xipD-5ce8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		5 LEU A  55
GLU A  42
PRO A  79
THR A  78
GLU A 122
 None
None
None
SR  A 401 (-3.4A)
None
 1.25A 5xipD-5m8hA:
15.6		 5xipD-5m8hA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 5 LEU A 323
VAL A 321
PRO A 246
THR A 247
THR A 355
 None
 1.49A 5xipD-5mhfA:
undetectable		 5xipD-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mun LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF08126
(Propeptide_C25) 		5 LEU A 186
GLU A  53
VAL A  67
PRO A  84
THR A  33
 None
None
None
None
AZI  A 301 (-4.6A)
 1.43A 5xipD-5munA:
undetectable		 5xipD-5munA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 5 LEU A 215
GLU A 271
VAL A 274
THR A 260
THR A 542
 None
 1.24A 5xipD-5npuA:
2.1		 5xipD-5npuA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		11 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
GLU A1123
ARG A1152
TRP A1169
GLU A1171
THR A1240
TRP A1273
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
91Y  A1601 (-4.2A)
None
 0.73A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
GLU A1123
THR A1222
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
None
 1.36A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		10 LEU A1087
VAL A1101
PRO A1120
GLU A1123
ARG A1152
TRP A1169
GLU A1171
PHE A1216
THR A1240
TRP A1273
 None
None
None
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
None
 0.71A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 VAL A1101
PRO A1120
THR A1121
GLU A1171
PHE A1248
TRP A1273
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.7A)
None
None
 1.42A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		5 LEU A 835
GLU A1130
GLU A 870
ARG A1128
GLU A 880
 None
 1.20A 5xipD-5wvrA:
undetectable		 5xipD-5wvrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMS
ICMO (DOTL)

(Legionella
pneumophila;
Legionella
pneumophila) 		PF12608
(T4bSS_IcmS)
no annotation 		5 LEU C 733
VAL A  83
PRO A  81
THR A  80
ARG A  85
 None
 1.38A 5xipD-5x1eC:
undetectable		 5xipD-5x1eC:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 7 GLU A 472
THR A 439
GLU A 441
ARG A 470
TRP A 487
GLU A 489
TRP A 589
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
None
None
None
 1.37A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 6 LEU A 405
GLU A 418
VAL A 419
GLU A 441
PHE A 534
THR A 540
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-3.0A)
86X  A1004 (-3.6A)
None
 1.48A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 12 LEU A 405
GLU A 418
VAL A 419
PRO A 438
THR A 439
GLU A 441
ARG A 470
TRP A 487
GLU A 489
PHE A 534
THR A 558
TRP A 589
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
None
 0.39A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 6 VAL A 419
PRO A 438
THR A 439
GLU A 489
PHE A 566
TRP A 589
 86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
None
None
None
 1.40A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 6 GLU A 361
TRP A 407
GLU A 409
PHE A 454
THR A 478
TRP A 511
 None
 0.61A 5xipD-5xilA:
46.3		 5xipD-5xilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 7 GLU A 364
THR A 331
ARG A 362
TRP A 379
GLU A 381
THR A 450
TRP A 481
 ANP  A 803 (-3.7A)
HFG  A 801 (-3.4A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
ANP  A 803 (-3.9A)
None
 1.43A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 9 LEU A 297
GLU A 310
VAL A 311
THR A 331
GLU A 333
ARG A 362
TRP A 379
PHE A 426
THR A 450
 None
None
HFG  A 801 (-4.3A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
 0.65A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 11 LEU A 297
VAL A 311
PRO A 330
THR A 331
GLU A 333
ARG A 362
TRP A 379
GLU A 381
PHE A 426
THR A 450
TRP A 481
 None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
None
 0.39A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 6 VAL A 311
PRO A 330
THR A 331
GLU A 381
PHE A 458
TRP A 481
 HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
HFG  A 801 (-3.4A)
HFG  A 801 ( 4.9A)
None
None
 1.42A 5xipD-5xioA:
50.6		 5xipD-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 7 GLU A 392
THR A 359
ARG A 390
TRP A 407
GLU A 409
THR A 478
TRP A 509
 ANP  A1001 (-3.8A)
HFG  A1003 (-3.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
ANP  A1001 ( 3.7A)
None
 1.31A 5xipD-5xipA:
54.4		 5xipD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 12 LEU A 325
GLU A 338
VAL A 339
PRO A 358
THR A 359
GLU A 361
ARG A 390
TRP A 407
GLU A 409
PHE A 454
THR A 478
TRP A 509
 None
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
None
 0.34A 5xipD-5xipA:
54.4		 5xipD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 6 VAL A 339
PRO A 358
THR A 359
GLU A 409
PHE A 486
TRP A 509
 HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
HFG  A1003 (-3.9A)
HFG  A1003 ( 4.8A)
None
None
 1.36A 5xipD-5xipA:
54.4		 5xipD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6v ABC-TYPE
UNCHARACTERIZED
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Rhodothermus
marinus) 		no annotation 5 LEU A 106
GLU A  60
VAL A  61
PRO A  30
THR A  29
 None
 1.48A 5xipD-5z6vA:
2.9		 5xipD-5z6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU O 487
GLU O 649
VAL O 650
GLU O 320
THR O 142
 None
 1.38A 5xipD-6eu2O:
undetectable		 5xipD-6eu2O:
undetectable