SIMILAR PATTERNS OF AMINO ACIDS FOR 5XIP_A_HFGA1003_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 GLU A 450
TRP A 117
HIS A 447
 None
 0.89A 5xipA-1b41A:
0.0		 5xipA-1b41A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		3 GLU A 450
TRP A 117
HIS A 447
 None
 0.93A 5xipA-1c2oA:
0.0		 5xipA-1c2oA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		3 GLU A 402
TRP A 102
HIS A 399
 None
 0.90A 5xipA-1c7jA:
0.0		 5xipA-1c7jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		3 GLU A 170
TRP A 180
HIS A 123
 None
 0.76A 5xipA-1edgA:
0.0		 5xipA-1edgA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		3 GLU A 443
TRP A 114
HIS A 440
 None
None
EMM  A1999 ( 3.8A)
 0.96A 5xipA-1gqrA:
1.1		 5xipA-1gqrA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A 113
TRP A 158
HIS A 230
 None
 0.90A 5xipA-1hc7A:
46.6		 5xipA-1hc7A:
44.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 209
HIS A  94
 ZN  A 901 ( 4.5A)
None
ZN  A 901 ( 3.2A)
 1.03A 5xipA-1jd0A:
0.0		 5xipA-1jd0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 117
TRP A 209
HIS A  94
 None
None
ZN  A 901 ( 3.2A)
 1.12A 5xipA-1jd0A:
0.0		 5xipA-1jd0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		3 GLU A  98
TRP A 187
HIS A  92
 ZN  A 301 ( 4.6A)
None
ZN  A 301 ( 3.2A)
 0.98A 5xipA-1kopA:
0.0		 5xipA-1kopA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		3 GLU A 109
TRP A 187
HIS A  92
 None
None
ZN  A 301 ( 3.2A)
 0.97A 5xipA-1kopA:
0.0		 5xipA-1kopA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		3 GLU A 605
TRP A 437
HIS A 347
 None
ACR  A 700 (-4.8A)
None
 1.12A 5xipA-1lf9A:
0.0		 5xipA-1lf9A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		3 GLU A 203
TRP A  75
HIS A 173
 None
 1.06A 5xipA-1p1mA:
undetectable		 5xipA-1p1mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		3 GLU A 483
TRP A 146
HIS A 480
 None
None
SO4  A 593 (-4.1A)
 1.11A 5xipA-1qonA:
undetectable		 5xipA-1qonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 GLU A 305
TRP A  54
HIS A 298
 None
 1.06A 5xipA-1r9jA:
3.6		 5xipA-1r9jA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I
ENDO-1,4-BETA-XYLANA
SE

(Triticum
aestivum;
Aspergillus
nidulans) 		PF00704
(Glyco_hydro_18)
PF00331
(Glyco_hydro_10) 		3 GLU B 132
TRP B 212
HIS A 232
 None
 0.77A 5xipA-1ta3B:
undetectable		 5xipA-1ta3B:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 GLU A 288
TRP A 360
HIS A 299
 None
 1.10A 5xipA-1ufaA:
undetectable		 5xipA-1ufaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 209
HIS A  94
 ZN  A 280 ( 4.7A)
None
ZN  A 280 (-3.2A)
 0.93A 5xipA-1urtA:
undetectable		 5xipA-1urtA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 GLU A 117
TRP A 209
HIS A  94
 None
None
ZN  A 280 (-3.2A)
 1.04A 5xipA-1urtA:
undetectable		 5xipA-1urtA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		3 GLU A 122
TRP A 227
HIS A 115
 ZN  A 283 ( 4.5A)
None
ZN  A 283 ( 3.2A)
 1.09A 5xipA-1y7wA:
undetectable		 5xipA-1y7wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		3 GLU A 133
TRP A 227
HIS A 115
 None
None
ZN  A 283 ( 3.2A)
 1.11A 5xipA-1y7wA:
undetectable		 5xipA-1y7wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		3 GLU A 511
TRP A 450
HIS A 522
 None
 0.79A 5xipA-2hyxA:
2.5		 5xipA-2hyxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 209
HIS A  94
 ZN  A 561 ( 4.9A)
None
ZN  A 561 ( 3.2A)
 1.07A 5xipA-2it4A:
undetectable		 5xipA-2it4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		3 GLU A 237
TRP A  98
HIS A 234
 GUN  A 600 (-2.8A)
None
GUN  A 600 ( 2.8A)
 0.89A 5xipA-2oodA:
undetectable		 5xipA-2oodA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25

(Homo sapiens) 		PF00621
(RhoGEF) 		3 GLU B 224
TRP B 234
HIS B 242
 None
 1.08A 5xipA-2rgnB:
undetectable		 5xipA-2rgnB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 GLU A 908
TRP A 896
HIS A1064
 None
 0.91A 5xipA-2vz9A:
undetectable		 5xipA-2vz9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 209
HIS A  94
 ZN  A   1 ( 4.8A)
None
ZN  A   1 ( 3.3A)
 0.96A 5xipA-2zncA:
undetectable		 5xipA-2zncA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 GLU A 117
TRP A 209
HIS A  94
 None
None
ZN  A   1 ( 3.3A)
 1.03A 5xipA-2zncA:
undetectable		 5xipA-2zncA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		3 GLU A 154
TRP A 164
HIS A 111
 None
 1.01A 5xipA-3ayrA:
undetectable		 5xipA-3ayrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		3 GLU A 169
TRP A 270
HIS A 163
 ZN  A 378 ( 4.5A)
None
ZN  A 378 (-3.2A)
 1.07A 5xipA-3b1bA:
undetectable		 5xipA-3b1bA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		3 GLU A 180
TRP A 270
HIS A 163
 None
None
ZN  A 378 (-3.2A)
 1.09A 5xipA-3b1bA:
undetectable		 5xipA-3b1bA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 107
TRP A 210
HIS A  95
 ZN  A 301 ( 4.9A)
None
ZN  A 301 ( 3.6A)
 1.12A 5xipA-3da2A:
undetectable		 5xipA-3da2A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A 601
TRP A 571
HIS A 603
 None
 0.94A 5xipA-3decA:
undetectable		 5xipA-3decA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A 601
TRP A 571
HIS A 895
 None
 1.06A 5xipA-3decA:
undetectable		 5xipA-3decA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 125
TRP A 230
HIS A 111
 MG  A 901 ( 4.4A)
None
MG  A 901 (-3.4A)
 0.87A 5xipA-3fe4A:
undetectable		 5xipA-3fe4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 136
TRP A 230
HIS A 111
 None
None
MG  A 901 (-3.4A)
 0.95A 5xipA-3fe4A:
undetectable		 5xipA-3fe4A:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A 148
TRP A 194
HIS A 266
 PR8  A 601 (-3.0A)
None
PR8  A 601 ( 3.9A)
 0.35A 5xipA-3ialA:
42.8		 5xipA-3ialA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4
PRE-MRNA-SPLICING
FACTOR CWF3

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF02184
(HAT)
PF02184
(HAT) 		3 GLU r 538
TRP r 553
HIS R 285
 None
 0.77A 5xipA-3jb9r:
undetectable		 5xipA-3jb9r:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 GLU A1471
TRP A1138
HIS A1468
 None
 1.07A 5xipA-3k9bA:
undetectable		 5xipA-3k9bA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		3 GLU A 118
TRP A 109
HIS A  90
 None
None
CA  A 471 (-3.6A)
 0.82A 5xipA-3lnpA:
undetectable		 5xipA-3lnpA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 209
HIS A  94
 ZN  A 263 ( 4.6A)
None
ZN  A 263 ( 3.2A)
 1.09A 5xipA-3ml5A:
undetectable		 5xipA-3ml5A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 GLU A  98
TRP A  30
HIS A  95
 CD  A 318 (-2.3A)
None
None
 1.00A 5xipA-3mmwA:
undetectable		 5xipA-3mmwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 GLU A  60
TRP A 228
HIS A 123
 None
 1.06A 5xipA-3nqhA:
undetectable		 5xipA-3nqhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		3 GLU A 129
TRP A 225
HIS A 123
 ZN  A   1 ( 4.7A)
MLT  A   3 (-4.9A)
ZN  A   1 ( 3.2A)
 1.08A 5xipA-3q31A:
undetectable		 5xipA-3q31A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		3 GLU A 140
TRP A 225
HIS A 123
 None
MLT  A   3 (-4.9A)
ZN  A   1 ( 3.2A)
 1.02A 5xipA-3q31A:
undetectable		 5xipA-3q31A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		3 GLU A 155
TRP A 162
HIS A 169
 GOL  A 278 (-3.4A)
PG4  A 274 ( 4.0A)
PG4  A 274 (-3.9A)
 1.09A 5xipA-3rq0A:
undetectable		 5xipA-3rq0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 208
HIS A  94
 ZN  A 261 ( 4.9A)
None
ZN  A 261 (-3.3A)
 0.93A 5xipA-3uyqA:
undetectable		 5xipA-3uyqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 117
TRP A 208
HIS A  94
 None
None
ZN  A 261 (-3.3A)
 1.07A 5xipA-3uyqA:
undetectable		 5xipA-3uyqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		3 GLU A 209
TRP A  81
HIS A 179
 UNL  A 436 ( 2.8A)
None
UNL  A 436 ( 3.9A)
 1.03A 5xipA-3v7pA:
undetectable		 5xipA-3v7pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		3 GLU A 107
TRP A  98
HIS A  80
 None
None
ZN  A 504 (-3.1A)
 0.92A 5xipA-4dzhA:
undetectable		 5xipA-4dzhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		3 GLU A 230
TRP A  98
HIS A 200
 ZN  A 505 ( 4.2A)
None
None
 1.10A 5xipA-4dzhA:
undetectable		 5xipA-4dzhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		3 GLU A  99
TRP A  90
HIS A  72
 NOS  A 501 ( 2.8A)
None
NOS  A 501 (-3.7A)
 1.01A 5xipA-4f0sA:
undetectable		 5xipA-4f0sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		3 GLU A 222
TRP A  90
HIS A 192
 NOS  A 501 (-3.0A)
None
NOS  A 501 (-4.0A)
 0.94A 5xipA-4f0sA:
undetectable		 5xipA-4f0sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		3 GLU A  79
TRP A 180
HIS A  64
 None
GOL  A 805 (-3.7A)
CBI  A 802 (-4.4A)
 0.75A 5xipA-4fusA:
undetectable		 5xipA-4fusA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		3 GLU A  95
TRP A 184
HIS A  89
 AZM  A 302 ( 4.6A)
None
ZN  A 301 ( 3.2A)
 1.10A 5xipA-4g7aA:
undetectable		 5xipA-4g7aA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 184
HIS A  89
 None
None
ZN  A 301 ( 3.2A)
 1.12A 5xipA-4g7aA:
undetectable		 5xipA-4g7aA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		3 GLU A 225
TRP A 100
HIS A 251
 None
 1.10A 5xipA-4hjwA:
undetectable		 5xipA-4hjwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		3 GLU A 193
TRP A 203
HIS A 149
 None
 0.96A 5xipA-4im4A:
undetectable		 5xipA-4im4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		3 GLU A  45
TRP A 148
HIS A 120
 None
 1.02A 5xipA-4jqsA:
2.6		 5xipA-4jqsA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		3 GLU A 225
TRP A 100
HIS A 251
 None
 1.07A 5xipA-4lanA:
undetectable		 5xipA-4lanA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C

(Butyrivibrio
proteoclasticus) 		PF00150
(Cellulase) 		3 GLU A 189
TRP A 199
HIS A 141
 None
 0.98A 5xipA-4nf7A:
undetectable		 5xipA-4nf7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		3 GLU A 392
TRP A 458
HIS A 482
 None
None
NI  A 501 (-3.4A)
 0.87A 5xipA-4oflA:
2.2		 5xipA-4oflA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 209
HIS A  94
 ZN  A 301 ( 4.5A)
None
ZN  A 301 (-3.2A)
 1.07A 5xipA-4qk3A:
undetectable		 5xipA-4qk3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		3 GLU A 443
TRP A 114
HIS A 440
 None
 0.90A 5xipA-4qwwA:
undetectable		 5xipA-4qwwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		3 GLU A  88
TRP A 388
HIS A 126
 None
 0.81A 5xipA-4r27A:
undetectable		 5xipA-4r27A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		3 GLU A 118
TRP A 208
HIS A 112
 AZM  A 299 ( 4.4A)
None
ZN  A 298 (-3.2A)
 1.07A 5xipA-4uovA:
undetectable		 5xipA-4uovA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		3 GLU A 129
TRP A 208
HIS A 112
 None
None
ZN  A 298 (-3.2A)
 1.08A 5xipA-4uovA:
undetectable		 5xipA-4uovA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		3 GLU A 168
TRP A 175
HIS A 182
 GLU  A 168 (-0.5A)
TRP  A 175 ( 0.5A)
HIS  A 182 ( 1.0A)
 1.03A 5xipA-4w65A:
undetectable		 5xipA-4w65A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 GLU A 240
TRP A 250
HIS A 195
 BGC  A 502 ( 3.2A)
BGC  A 502 ( 3.8A)
None
 1.06A 5xipA-4w87A:
undetectable		 5xipA-4w87A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzf 1,3-BETA-GLUCANASE

(Mycobacterium
tuberculosis) 		PF00722
(Glyco_hydro_16) 		3 GLU A 176
TRP A 183
HIS A 190
 EDO  A 402 (-3.5A)
None
None
 1.11A 5xipA-4wzfA:
undetectable		 5xipA-4wzfA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		3 GLU A 116
TRP A 201
HIS A 110
 ZN  A 301 (-4.9A)
None
ZN  A 301 (-3.3A)
 0.98A 5xipA-4xfwA:
undetectable		 5xipA-4xfwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 GLU A 441
TRP A 112
HIS A 438
 None
None
40V  A1001 (-3.6A)
 0.87A 5xipA-4xiiA:
undetectable		 5xipA-4xiiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		3 GLU A 166
TRP A 264
HIS A 160
 2HP  A 402 ( 4.7A)
None
ZN  A 401 ( 3.2A)
 1.08A 5xipA-4xixA:
undetectable		 5xipA-4xixA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		3 GLU A 177
TRP A 264
HIS A 160
 None
None
ZN  A 401 ( 3.2A)
 1.10A 5xipA-4xixA:
undetectable		 5xipA-4xixA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		3 GLU A  46
TRP A 149
HIS A  31
 None
PGE  A 712 ( 3.8A)
None
 0.74A 5xipA-4xwlA:
undetectable		 5xipA-4xwlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		3 GLU A 164
TRP A 171
HIS A 178
 None
 1.00A 5xipA-4xxpA:
undetectable		 5xipA-4xxpA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		3 GLU A 171
TRP A 262
HIS A 165
 ZN  A 401 ( 4.5A)
None
ZN  A 401 ( 3.2A)
 1.04A 5xipA-4xz5A:
undetectable		 5xipA-4xz5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		3 GLU A 182
TRP A 262
HIS A 165
 None
None
ZN  A 401 ( 3.2A)
 1.10A 5xipA-4xz5A:
undetectable		 5xipA-4xz5A:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A 361
TRP A 407
HIS A 480
 HFG  A 802 (-2.9A)
None
HFG  A 802 (-4.0A)
 0.99A 5xipA-4ydqA:
50.7		 5xipA-4ydqA:
63.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjf GLYCOPROTEIN

(Lassa
mammarenavirus) 		PF00798
(Arena_glycoprot) 		3 GLU A 104
TRP A 227
HIS A  93
 None
 0.95A 5xipA-4zjfA:
undetectable		 5xipA-4zjfA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		3 GLU A 216
TRP A 465
HIS A 316
 GAL  A 701 (-2.8A)
LOG  A 702 (-3.8A)
None
 0.58A 5xipA-5bxpA:
3.0		 5xipA-5bxpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxd PUTATIVE
BETA-GLUCANASE

(Mycobacteroides
abscessus) 		PF00722
(Glyco_hydro_16) 		3 GLU A 146
TRP A 153
HIS A 160
 None
 1.10A 5xipA-5dxdA:
undetectable		 5xipA-5dxdA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		3 GLU X 105
TRP X 207
HIS X  93
 ZN  X 301 ( 4.6A)
None
ZN  X 301 (-3.2A)
 1.10A 5xipA-5eztX:
undetectable		 5xipA-5eztX:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		3 GLU A 162
TRP A 179
HIS A  73
 None
 0.67A 5xipA-5f5wA:
7.7		 5xipA-5f5wA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		3 GLU A 452
TRP A 121
HIS A 449
 None
 0.88A 5xipA-5fv4A:
undetectable		 5xipA-5fv4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3b UNCHARACTERIZED
PROTEIN HI_1552

(Haemophilus
influenzae) 		PF04301
(DUF452) 		3 GLU A  72
TRP A 187
HIS A 165
 None
 0.95A 5xipA-5h3bA:
undetectable		 5xipA-5h3bA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLU A 224
TRP A 301
HIS A 221
 None
 0.91A 5xipA-5h80A:
3.1		 5xipA-5h80A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		3 GLU A 102
TRP A 192
HIS A  96
 ZN  A 301 ( 4.6A)
None
ZN  A 301 (-3.2A)
 1.06A 5xipA-5hpjA:
undetectable		 5xipA-5hpjA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		3 GLU A 113
TRP A 192
HIS A  96
 None
None
ZN  A 301 (-3.2A)
 1.00A 5xipA-5hpjA:
undetectable		 5xipA-5hpjA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 106
TRP A 209
HIS A  94
 ZN  A 301 ( 4.6A)
None
ZN  A 301 ( 3.3A)
 0.97A 5xipA-5jn9A:
undetectable		 5xipA-5jn9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 GLU A 117
TRP A 209
HIS A  94
 None
None
ZN  A 301 ( 3.3A)
 1.11A 5xipA-5jn9A:
undetectable		 5xipA-5jn9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbo GLYCOSYL HYDROLASE
FAMILY 16

(Bacteroides
ovatus) 		no annotation 3 GLU A  62
TRP A 129
HIS A  54
 None
 0.98A 5xipA-5nboA:
undetectable		 5xipA-5nboA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nff GLYCOPROTEIN

(Morogoro
mammarenavirus) 		no annotation 3 GLU B 103
TRP B 225
HIS B  92
 None
 1.00A 5xipA-5nffB:
undetectable		 5xipA-5nffB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 3 GLU D 256
TRP D 279
HIS D 140
 None
 1.09A 5xipA-5uz5D:
undetectable		 5xipA-5uz5D:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A1123
TRP A1169
HIS A1242
 PRO  A1602 (-2.8A)
None
PRO  A1602 (-4.1A)
 0.42A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 3 GLU A 441
TRP A 487
HIS A 560
 86X  A1004 (-3.0A)
None
86X  A1004 (-3.7A)
 0.25A 5xipA-5xiiA:
53.0		 5xipA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 3 GLU A 361
TRP A 407
HIS A 480
 None
 0.83A 5xipA-5xilA:
49.8		 5xipA-5xilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 3 GLU A 333
TRP A 379
HIS A 452
 HFG  A 801 (-3.0A)
None
HFG  A 801 (-4.2A)
 0.27A 5xipA-5xioA:
50.3		 5xipA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 3 GLU A 361
TRP A 407
HIS A 480
 HFG  A1003 (-2.9A)
HFG  A1003 (-4.7A)
HFG  A1003 (-3.5A)
 0.00A 5xipA-5xipA:
62.1		 5xipA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 3 GLU A 603
TRP A 275
HIS A 600
 None
 0.93A 5xipA-6arxA:
undetectable		 5xipA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 3 GLU A 134
TRP A 212
HIS A 117
 None
None
ZN  A 301 (-3.3A)
 1.11A 5xipA-6ekiA:
undetectable		 5xipA-6ekiA:
undetectable