SIMILAR PATTERNS OF AMINO ACIDS FOR 5XIO_A_HFGA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		5 GLU A 167
HIS A  95
THR A 130
SER A  96
GLY A 128
 PGA  A 600 (-2.4A)
PGA  A 600 (-4.0A)
None
None
None
 1.39A 5xioA-1amkA:
undetectable		 5xioA-1amkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		5 GLU A 168
HIS A  96
THR A 131
SER A  97
GLY A 129
 None
 1.37A 5xioA-1b9bA:
undetectable		 5xioA-1b9bA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE
ALPHA CHAIN
4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis;
Sphingomonas
paucimobilis) 		PF07746
(LigA)
PF02900
(LigB) 		5 VAL B 155
GLU B  86
PHE A  96
THR A  98
GLY B  87
 None
 1.33A 5xioA-1bouB:
undetectable		 5xioA-1bouB:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 GLU A 144
TRP A 158
GLU A 160
HIS A 162
THR A 228
SER A 258
GLY A 260
 None
 1.17A 5xioA-1hc7A:
45.4		 5xioA-1hc7A:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		8 PRO A 110
ARG A 142
TRP A 158
GLU A 160
HIS A 162
PHE A 205
THR A 228
GLY A 260
 None
 0.69A 5xioA-1hc7A:
45.4		 5xioA-1hc7A:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		8 PRO A 110
TRP A 158
GLU A 160
HIS A 162
PHE A 205
THR A 228
SER A 258
GLY A 260
 None
 0.58A 5xioA-1hc7A:
45.4		 5xioA-1hc7A:
40.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLU A  72
PRO A 143
THR A  44
SER A 157
GLY A 155
 ZN  A 400 (-2.1A)
None
None
None
None
 1.47A 5xioA-1kwmA:
2.3		 5xioA-1kwmA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 GLU A  96
VAL A  97
PRO A 116
ARG A 148
GLU A 168
HIS A 170
GLY A 267
 None
None
None
5CA  A 512 (-2.9A)
None
None
5CA  A 512 (-3.9A)
 0.60A 5xioA-1nj1A:
42.7		 5xioA-1nj1A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 GLU A  96
VAL A  97
PRO A 116
ARG A 148
HIS A 170
THR A 218
 None
None
None
5CA  A 512 (-2.9A)
None
None
 1.32A 5xioA-1nj1A:
42.7		 5xioA-1nj1A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 VAL A  97
HIS A 170
PHE A 212
THR A 235
GLY A 267
 None
None
5CA  A 512 (-4.0A)
5CA  A 512 (-3.0A)
5CA  A 512 (-3.9A)
 0.94A 5xioA-1nj1A:
42.7		 5xioA-1nj1A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		7 VAL A  97
PRO A 116
ARG A 148
GLU A 168
HIS A 170
THR A 235
GLY A 267
 None
None
5CA  A 512 (-2.9A)
None
None
5CA  A 512 (-3.0A)
5CA  A 512 (-3.9A)
 0.49A 5xioA-1nj1A:
42.7		 5xioA-1nj1A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		7 GLU A  80
VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.48A 5xioA-1nj8A:
40.8		 5xioA-1nj8A:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 GLU A  80
VAL A  81
PRO A 100
HIS A 154
PHE A 196
 None
 0.93A 5xioA-1nj8A:
40.8		 5xioA-1nj8A:
37.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		5 PHE A 133
VAL A 144
PRO A 137
GLU A 159
GLY A 122
 None
 1.44A 5xioA-1nrkA:
undetectable		 5xioA-1nrkA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 PHE A 508
GLU A 458
PRO A 534
PHE A 450
SER A 445
 None
 1.37A 5xioA-1ozhA:
undetectable		 5xioA-1ozhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 GLU A 160
VAL A 123
PRO A  29
ARG A 122
THR A  20
 None
 1.46A 5xioA-1rp1A:
2.8		 5xioA-1rp1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryl HYPOTHETICAL PROTEIN
YFBM

(Escherichia
coli) 		PF08974
(DUF1877) 		5 PHE A  59
PHE A  84
THR A 163
SER A  76
GLY A  73
 None
 1.47A 5xioA-1rylA:
undetectable		 5xioA-1rylA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		5 VAL A  82
PRO A  56
GLU A   5
HIS A 196
SER A 198
 None
 1.48A 5xioA-1twdA:
undetectable		 5xioA-1twdA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02347
(GDC-P)
PF02347
(GDC-P) 		5 VAL B 317
PRO B 129
ARG B 318
HIS B 265
THR A 326
 None
 1.49A 5xioA-1wytB:
undetectable		 5xioA-1wytB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		5 GLU A 149
VAL A 150
HIS A 197
PHE A  80
GLY A 219
 None
None
CH6  A  63 ( 3.5A)
None
None
 1.14A 5xioA-1xqmA:
undetectable		 5xioA-1xqmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 PHE A 192
VAL A 419
PRO A 314
THR A 203
SER A 199
 None
 1.47A 5xioA-2cjqA:
undetectable		 5xioA-2cjqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.12A 5xioA-2dq3A:
11.6		 5xioA-2dq3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 PHE A 410
GLU A 415
VAL A 413
GLU A 480
GLY A 446
 None
CA  A 701 (-2.3A)
None
None
None
 1.42A 5xioA-2erqA:
2.7		 5xioA-2erqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		5 GLU A 236
VAL A 308
THR A 334
SER A 190
GLY A 314
 None
 1.35A 5xioA-2greA:
undetectable		 5xioA-2greA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 PHE A  11
VAL A   9
THR A 126
SER A  84
GLY A 130
 None
 1.47A 5xioA-2hxgA:
2.5		 5xioA-2hxgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 PHE A 288
VAL A 310
GLU A 164
THR A 323
GLY A  65
 None
None
None
None
SO4  A1373 (-3.9A)
 1.31A 5xioA-2iu4A:
undetectable		 5xioA-2iu4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE

(Anopheles
gambiae) 		PF01048
(PNP_UDP_1) 		5 GLU A 174
PRO A 283
GLU A 286
THR A 327
GLY A 203
 None
None
DIH  A 401 (-2.8A)
DIH  A 401 (-4.2A)
DIH  A 401 (-3.4A)
 1.20A 5xioA-2p4sA:
2.4		 5xioA-2p4sA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		5 PHE A 265
GLU A 219
PRO A 268
SER A   8
GLY A 275
 None
 1.35A 5xioA-2qw5A:
undetectable		 5xioA-2qw5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PHE B 272
ARG B 330
TRP B 146
HIS B 404
THR B 460
 None
None
None
None
HPA  B1780 (-3.6A)
 1.36A 5xioA-2w55B:
undetectable		 5xioA-2w55B:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 GLU A 215
VAL A 216
HIS A  49
PHE A  81
GLY A 140
 None
 1.34A 5xioA-2yijA:
undetectable		 5xioA-2yijA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 PHE A 110
GLU A 109
VAL A 112
THR A 235
GLY A 271
 UNL  A 420 (-3.6A)
None
None
None
None
 1.24A 5xioA-3b9yA:
undetectable		 5xioA-3b9yA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 PHE A 124
VAL A 129
PHE A 111
THR A 157
GLY A 155
 None
 1.32A 5xioA-3bqyA:
undetectable		 5xioA-3bqyA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f44 PUTATIVE
MONOOXYGENASE

(Lactobacillus
acidophilus) 		PF03992
(ABM) 		5 VAL A 124
GLU A 169
HIS A 180
THR A 101
SER A 143
 None
 1.45A 5xioA-3f44A:
undetectable		 5xioA-3f44A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2u RAVER-1

(Homo sapiens) 		PF00076
(RRM_1) 		5 PHE B 162
GLU B  52
HIS B 206
THR B 130
GLY B 211
 None
 1.42A 5xioA-3h2uB:
undetectable		 5xioA-3h2uB:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 PRO A 145
ARG A 177
TRP A 194
GLU A 196
HIS A 198
GLY A 296
 None
PR8  A 601 ( 4.3A)
None
PR8  A 601 (-4.5A)
PR8  A 601 ( 4.5A)
PR8  A 601 (-3.4A)
 0.28A 5xioA-3ialA:
42.2		 5xioA-3ialA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 VAL A  75
PRO A 182
HIS A 161
PHE A 165
GLY A  94
 None
 1.42A 5xioA-3ifwA:
undetectable		 5xioA-3ifwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		5 GLU A  93
PRO A 186
GLU A 189
THR A 230
GLY A 122
 None
None
GNG  A 800 (-2.9A)
GNG  A 800 (-3.9A)
GNG  A 800 (-3.6A)
 1.30A 5xioA-3iomA:
undetectable		 5xioA-3iomA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		5 GLU A 192
GLU A 158
THR A 113
SER A 260
GLY A 138
 None
None
LEU  A 400 (-3.7A)
LEU  A 400 (-4.6A)
None
 1.11A 5xioA-3lopA:
3.0		 5xioA-3lopA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		5 GLU A 327
VAL A 336
GLU A 138
HIS A 291
GLY A 136
 None
 1.30A 5xioA-3muuA:
undetectable		 5xioA-3muuA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3org CMCLC

(Cyanidioschyzon
merolae) 		PF00654
(Voltage_CLC) 		5 VAL A 519
PRO A 168
GLU A 210
SER A 433
GLY A 208
 None
None
None
None
CL  A 802 (-3.6A)
 1.50A 5xioA-3orgA:
undetectable		 5xioA-3orgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ast ALDO-KETO REDUCTASE
AKR14A1

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 VAL A 203
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.39A 5xioA-4astA:
undetectable		 5xioA-4astA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 5 GLU A 241
GLU A 180
HIS A 125
PHE A 245
GLY A 178
 None
 1.43A 5xioA-4bg2A:
undetectable		 5xioA-4bg2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		5 VAL A  83
TRP A  42
GLU A 199
SER A 201
GLY A 198
 None
 1.39A 5xioA-4binA:
4.6		 5xioA-4binA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cza NA+/H+ ANTIPORTER,
PUTATIVE

(Pyrococcus
abyssi) 		PF00999
(Na_H_Exchanger) 		5 VAL A 405
PRO A 361
ARG A 362
GLU A 154
GLY A  96
 None
 1.40A 5xioA-4czaA:
undetectable		 5xioA-4czaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLU A  63
GLU A  22
HIS A 334
THR A 283
GLY A 342
 None
 1.46A 5xioA-4dpkA:
3.8		 5xioA-4dpkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 PHE A 328
VAL A 334
THR A 397
SER A 402
GLY A 400
 None
 1.25A 5xioA-4dyjA:
undetectable		 5xioA-4dyjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		5 GLU A 425
VAL A 423
PRO A 327
TRP A 350
GLY A 262
 None
 1.27A 5xioA-4el8A:
undetectable		 5xioA-4el8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		5 GLU A 111
GLU A 281
HIS A 206
SER A 227
GLY A  64
 None
ZN  A 401 (-2.2A)
ZN  A 401 (-3.4A)
None
None
 1.49A 5xioA-4h0fA:
undetectable		 5xioA-4h0fA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrf PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
ovatus) 		PF15495
(Fimbrillin_C) 		5 PRO A 484
GLU A 417
PHE A 434
SER A 419
GLY A 415
 None
 1.48A 5xioA-4jrfA:
undetectable		 5xioA-4jrfA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 5 PHE A 144
VAL A 194
ARG A 131
PHE A 117
THR A  90
 None
 1.33A 5xioA-4lgnA:
undetectable		 5xioA-4lgnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lna PURINE NUCLEOSIDE
PHOSPHORYLASE

(Spirosoma
linguale) 		PF01048
(PNP_UDP_1) 		5 GLU A  84
PRO A 189
GLU A 192
THR A 233
GLY A 113
 None
None
ADE  A 502 (-2.9A)
ADE  A 502 (-4.3A)
ADE  A 502 (-3.6A)
 1.17A 5xioA-4lnaA:
2.2		 5xioA-4lnaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE

(Planctopirus
limnophila) 		PF01048
(PNP_UDP_1) 		5 GLU A  87
PRO A 191
GLU A 194
THR A 235
GLY A 116
 None
None
ADE  A 401 (-2.7A)
ADE  A 401 (-4.3A)
ADE  A 401 (-3.7A)
 1.14A 5xioA-4m1eA:
2.8		 5xioA-4m1eA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		5 PHE A 195
PRO A 194
PHE A 222
THR A 155
GLY A 209
 ORO  A 403 ( 3.8A)
CL  A 401 (-4.4A)
None
None
None
 1.38A 5xioA-4nn3A:
undetectable		 5xioA-4nn3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Porphyromonas
gingivalis) 		PF01048
(PNP_UDP_1) 		5 GLU A 102
PRO A 205
GLU A 208
THR A 249
GLY A 131
 None
None
DA  A 301 (-2.7A)
DA  A 301 (-4.1A)
DA  A 301 (-3.4A)
 1.21A 5xioA-4ns1A:
undetectable		 5xioA-4ns1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 GLU A 757
VAL A 753
PRO A 418
HIS A 268
PHE A 432
 None
 1.21A 5xioA-4qi7A:
undetectable		 5xioA-4qi7A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6) 		PF13417
(GST_N_3) 		5 PHE A 237
GLU A 209
PRO A 205
PHE A 221
GLY A 232
 None
 1.42A 5xioA-4yamA:
undetectable		 5xioA-4yamA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Rattus
norvegicus) 		PF00083
(Sugar_tr) 		5 VAL A 163
PRO A 392
THR A 451
SER A 290
GLY A 286
 None
 1.38A 5xioA-4ybqA:
undetectable		 5xioA-4ybqA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		11 PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
HFG  A 802 ( 4.9A)
HFG  A 802 (-4.5A)
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.52A 5xioA-4ydqA:
50.6		 5xioA-4ydqA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		10 PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
PHE A 454
THR A 478
SER A 508
GLY A 510
 HFG  A 802 (-3.4A)
MG  A 803 ( 4.1A)
HFG  A 802 (-4.1A)
HFG  A 802 (-4.2A)
ANP  A 801 ( 2.5A)
None
HFG  A 802 (-3.6A)
HFG  A 802 ( 4.0A)
HFG  A 802 ( 3.8A)
HFG  A 802 (-3.7A)
 0.77A 5xioA-4ydqA:
50.6		 5xioA-4ydqA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		5 VAL A 535
PRO A 530
HIS A  97
SER A  95
GLY A 525
 None
 1.47A 5xioA-5d6aA:
2.2		 5xioA-5d6aA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2

(Aedes aegypti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 VAL A 207
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.42A 5xioA-5ft3A:
undetectable		 5xioA-5ft3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.03A 5xioA-5gkqA:
undetectable		 5xioA-5gkqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 GLU A  82
VAL A 114
GLU A  11
THR A 131
GLY A  13
 None
 1.42A 5xioA-5gqtA:
undetectable		 5xioA-5gqtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t79 ALDO-KETO REDUCTASE,
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 VAL A 203
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
None
None
None
NDP  A 404 (-3.0A)
 1.42A 5xioA-5t79A:
undetectable		 5xioA-5t79A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 GLU A  89
PRO A 198
GLU A 201
THR A 242
GLY A 118
 None
None
IM5  A 308 (-2.9A)
IM5  A 308 (-4.3A)
IM5  A 308 (-3.7A)
 1.12A 5xioA-5ugfA:
undetectable		 5xioA-5ugfA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 GLU A1154
PRO A1120
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.88A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		8 GLU A1154
PRO A1120
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.96A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		6 VAL A1101
PRO A1120
ARG A1152
HIS A1173
THR A1222
SER A1272
 None
None
PRO  A1602 ( 3.4A)
PRO  A1602 ( 4.5A)
None
PRO  A1602 (-3.3A)
 1.42A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		9 VAL A1101
PRO A1120
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
GLY A1274
 None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.60A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		8 VAL A1101
PRO A1120
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.79A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 5 PHE A 134
GLU A 132
PRO A 149
THR A  23
GLY A  21
 None
 1.49A 5xioA-5vehA:
undetectable		 5xioA-5vehA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC

(Medicago
truncatula) 		PF00815
(Histidinol_dh) 		5 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.28A 5xioA-5vldA:
2.4		 5xioA-5vldA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 9 PHE A 415
GLU A 418
VAL A 419
PRO A 438
ARG A 470
PHE A 534
THR A 558
SER A 588
GLY A 590
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.65A 5xioA-5xiiA:
51.7		 5xioA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 11 PHE A 415
VAL A 419
PRO A 438
ARG A 470
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
GLY A 590
 86X  A1004 (-3.6A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.40A 5xioA-5xiiA:
51.7		 5xioA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 7 TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 510
GLY A 512
 None
 0.41A 5xioA-5xilA:
46.0		 5xioA-5xilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 5 PHE A 307
GLU A 310
HIS A 383
THR A 432
SER A 480
 HFG  A 801 (-3.7A)
None
HFG  A 801 ( 4.7A)
None
HFG  A 801 ( 3.8A)
 1.38A 5xioA-5xioA:
60.2		 5xioA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 12 PHE A 307
GLU A 310
VAL A 311
PRO A 330
ARG A 362
TRP A 379
GLU A 381
HIS A 383
PHE A 426
THR A 450
SER A 480
GLY A 482
 HFG  A 801 (-3.7A)
None
HFG  A 801 (-4.3A)
HFG  A 801 ( 4.8A)
ANP  A 803 ( 3.1A)
None
HFG  A 801 ( 4.9A)
HFG  A 801 ( 4.7A)
HFG  A 801 (-3.7A)
ANP  A 803 (-3.9A)
HFG  A 801 ( 3.8A)
HFG  A 801 (-3.9A)
 0.00A 5xioA-5xioA:
60.2		 5xioA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 11 GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
PHE A 454
THR A 478
SER A 508
GLY A 510
 MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
HFG  A1003 (-3.4A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.59A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 6 GLU A 392
ARG A 390
GLU A 409
HIS A 411
THR A 478
SER A 508
 ANP  A1001 (-3.8A)
ANP  A1001 (-2.8A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
 1.42A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 11 PHE A 335
GLU A 338
VAL A 339
PRO A 358
ARG A 390
TRP A 407
GLU A 409
HIS A 411
THR A 478
SER A 508
GLY A 510
 HFG  A1003 (-3.8A)
MG  A1002 ( 4.3A)
HFG  A1003 ( 4.6A)
HFG  A1003 (-4.3A)
ANP  A1001 (-2.8A)
HFG  A1003 (-4.7A)
HFG  A1003 ( 4.8A)
HFG  A1003 ( 4.7A)
ANP  A1001 ( 3.7A)
HFG  A1003 ( 3.9A)
HFG  A1003 ( 3.9A)
 0.82A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 GLU A 349
VAL A 348
PRO A 527
PHE A 572
GLY A 534
 None
 1.46A 5xioA-6byiA:
undetectable		 5xioA-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6grw -

(-) 		no annotation 5 PRO A 407
GLU A 290
HIS A 266
SER A 267
GLY A 292
 None
 1.19A 5xioA-6grwA:
2.2		 5xioA-6grwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		3 THR A 268
GLU A 270
HIS A  69
 None
 0.79A 5xioA-1arlA:
undetectable		 5xioA-1arlA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 THR A 177
GLU A 316
HIS A  65
 NAD  A 375 (-3.6A)
NAD  A 375 ( 4.3A)
ZN  A 372 (-3.4A)
 0.62A 5xioA-1f8fA:
3.4		 5xioA-1f8fA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		3 THR A 171
GLU A 166
HIS A  93
 None
 0.81A 5xioA-1gzjA:
undetectable		 5xioA-1gzjA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc4 METHYLMALONYL-COA
EPIMERASE

(Propionibacterium
freudenreichii) 		PF13669
(Glyoxalase_4) 		3 THR A 122
GLU A  48
HIS A  91
 SO4  A 203 (-3.0A)
SO4  A 203 (-3.6A)
None
 0.88A 5xioA-1jc4A:
undetectable		 5xioA-1jc4A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		3 THR A  87
GLU A 239
HIS A 232
 None
 0.89A 5xioA-1m54A:
undetectable		 5xioA-1m54A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 THR A 264
GLU A 126
HIS A 123
 None
 0.76A 5xioA-1m7sA:
undetectable		 5xioA-1m7sA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A 117
GLU A 119
HIS A 237
 5CA  A 512 (-3.5A)
5CA  A 512 (-3.0A)
5CA  A 512 (-4.4A)
 0.46A 5xioA-1nj1A:
42.8		 5xioA-1nj1A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		3 THR A 101
GLU A 103
HIS A 221
 None
 0.76A 5xioA-1nj8A:
40.8		 5xioA-1nj8A:
37.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 THR A 274
GLU A 196
HIS A 336
 None
 0.72A 5xioA-1o2dA:
3.6		 5xioA-1o2dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 THR A 516
GLU A 518
HIS A 645
 None
 0.88A 5xioA-1o94A:
3.7		 5xioA-1o94A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 THR A 255
GLU A 282
HIS A  51
 None
 0.86A 5xioA-1q1nA:
3.5		 5xioA-1q1nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		3 THR A  71
GLU A 104
HIS A 132
 None
 0.85A 5xioA-1sfjA:
undetectable		 5xioA-1sfjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve0 HYPOTHETICAL PROTEIN
(ST2072)

(Sulfurisphaera
tokodaii) 		PF01894
(UPF0047) 		3 THR A  12
GLU A 118
HIS A  43
 None
None
SO4  A 135 (-4.1A)
 0.92A 5xioA-1ve0A:
undetectable		 5xioA-1ve0A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmf HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01894
(UPF0047) 		3 THR A   8
GLU A 116
HIS A  41
 None
None
ACT  A 135 (-4.1A)
 0.87A 5xioA-1vmfA:
undetectable		 5xioA-1vmfA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01128
(IspD) 		3 THR A  78
GLU A 175
HIS A 170
 None
 0.84A 5xioA-1vpaA:
3.7		 5xioA-1vpaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vph HYPOTHETICAL PROTEIN
SSO2532

(Sulfolobus
solfataricus) 		PF01894
(UPF0047) 		3 THR A  12
GLU A 120
HIS A  45
 None
None
PO4  A 139 (-3.9A)
 0.89A 5xioA-1vphA:
undetectable		 5xioA-1vphA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 THR A2309
GLU A2313
HIS A2379
 None
None
PO4  A3478 ( 4.7A)
 0.92A 5xioA-1wchA:
undetectable		 5xioA-1wchA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A  92
GLU A  47
HIS A  60
 None
 0.87A 5xioA-2avfA:
undetectable		 5xioA-2avfA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		3 THR A 234
GLU A 232
HIS A 141
 None
None
ZN  A 401 (-3.4A)
 0.75A 5xioA-2cbnA:
undetectable		 5xioA-2cbnA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A 123
GLU A  79
HIS A 177
 None
None
CU  A 401 (-3.1A)
 0.91A 5xioA-2dwsA:
undetectable		 5xioA-2dwsA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		3 THR A 210
GLU A 208
HIS A 134
 None
None
ZN  A1302 (-3.7A)
 0.75A 5xioA-2e7yA:
undetectable		 5xioA-2e7yA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Bacillus
subtilis) 		PF02390
(Methyltransf_4) 		3 THR A 101
GLU A 141
HIS A 134
 None
 0.89A 5xioA-2fcaA:
undetectable		 5xioA-2fcaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 148
GLU A 506
HIS A 446
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-4.0A)
 0.72A 5xioA-2fqdA:
undetectable		 5xioA-2fqdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 148
GLU A 506
HIS A 448
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.3A)
 0.75A 5xioA-2fqdA:
undetectable		 5xioA-2fqdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 THR A1802
GLU A1806
HIS A1871
 None
None
3UN  A 401 (-3.9A)
 0.91A 5xioA-2h03A:
undetectable		 5xioA-2h03A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.84A 5xioA-2i7tA:
undetectable		 5xioA-2i7tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 THR A 189
GLU A 286
HIS A 208
 None
 0.92A 5xioA-2ip4A:
3.5		 5xioA-2ip4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.90A 5xioA-2iyaA:
4.9		 5xioA-2iyaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 THR A1009
GLU A1013
HIS A1075
 None
 0.93A 5xioA-2ooqA:
undetectable		 5xioA-2ooqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6h HYPOTHETICAL PROTEIN

(Aeropyrum
pernix) 		PF01894
(UPF0047) 		3 THR A  10
GLU A 118
HIS A  43
 None
None
SO4  A 501 (-4.4A)
 0.92A 5xioA-2p6hA:
undetectable		 5xioA-2p6hA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		3 THR A  68
GLU A 104
HIS A 103
 NAD  A 358 ( 4.7A)
None
None
 0.89A 5xioA-2q1tA:
undetectable		 5xioA-2q1tA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		3 THR A 140
GLU A 388
HIS A 364
 TRS  A1478 ( 4.4A)
TRS  A1478 (-2.8A)
UDP  A1477 (-3.9A)
 0.88A 5xioA-2vg8A:
3.4		 5xioA-2vg8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 THR A  68
GLU A  38
HIS A 221
 None
None
FE2  A 401 ( 3.4A)
 0.83A 5xioA-2vw8A:
undetectable		 5xioA-2vw8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 (-3.5A)
 0.87A 5xioA-2xr1A:
undetectable		 5xioA-2xr1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		3 THR A 268
GLU A 270
HIS A 247
 None
 0.87A 5xioA-2xrcA:
undetectable		 5xioA-2xrcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 ( 3.3A)
 0.72A 5xioA-2ycbA:
undetectable		 5xioA-2ycbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A 394
GLU A 392
HIS A 344
 None
None
ZN  A 662 (-3.4A)
 0.80A 5xioA-3af5A:
undetectable		 5xioA-3af5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 139
GLU A 466
HIS A 396
 None
C2O  A 702 ( 4.5A)
C2O  A 702 ( 3.3A)
 0.88A 5xioA-3aw5A:
undetectable		 5xioA-3aw5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8z CYSTEINYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF01406
(tRNA-synt_1e) 		3 THR A  83
GLU A 230
HIS A 228
 5CA  A 418 (-3.4A)
None
None
 0.91A 5xioA-3c8zA:
undetectable		 5xioA-3c8zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 THR A 220
GLU A 125
HIS A 111
 None
MG  A 901 ( 4.4A)
MG  A 901 (-3.4A)
 0.88A 5xioA-3fe4A:
undetectable		 5xioA-3fe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		3 THR A 239
GLU A 241
HIS A  42
 None
SO4  A 368 ( 4.7A)
SO4  A 368 (-4.4A)
 0.91A 5xioA-3fmcA:
undetectable		 5xioA-3fmcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 THR A 385
GLU A 481
HIS A 480
 None
 0.87A 5xioA-3gszA:
undetectable		 5xioA-3gszA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 208
GLU A 609
HIS A 529
 None
C2O  A1002 ( 4.8A)
CU  A1004 ( 3.2A)
 0.90A 5xioA-3gyrA:
undetectable		 5xioA-3gyrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 THR A  92
GLU A  47
HIS A  60
 None
 0.91A 5xioA-3h4hA:
undetectable		 5xioA-3h4hA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A 146
GLU A 148
HIS A 266
 PR8  A 601 (-4.0A)
PR8  A 601 (-3.0A)
PR8  A 601 ( 3.9A)
 0.31A 5xioA-3ialA:
42.2		 5xioA-3ialA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 THR A 188
GLU A 186
HIS A 141
 U  E   1 ( 4.9A)
None
ZN  A 453 (-3.3A)
 0.78A 5xioA-3ie1A:
undetectable		 5xioA-3ie1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		3 THR A 342
GLU A 344
HIS A 171
 None
None
CL  A 387 (-4.6A)
 0.88A 5xioA-3k2kA:
undetectable		 5xioA-3k2kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 3 THR B 636
GLU B 541
HIS B 587
 None
 0.78A 5xioA-3kx2B:
undetectable		 5xioA-3kx2B:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		3 THR A 333
GLU A 335
HIS A 166
 UNL  A 378 ( 4.8A)
UNL  A 378 ( 3.3A)
CA  A 377 (-3.2A)
 0.93A 5xioA-3l2nA:
2.1		 5xioA-3l2nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		3 THR A  33
GLU A 342
HIS A 328
 None
None
MN  A 396 (-3.3A)
 0.92A 5xioA-3m8yA:
undetectable		 5xioA-3m8yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		3 THR A  56
GLU A 208
HIS A 201
 None
 0.92A 5xioA-3pc3A:
2.2		 5xioA-3pc3A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		3 THR A 323
GLU A 309
HIS A 294
 GOL  A 417 (-4.1A)
None
None
 0.71A 5xioA-3s9jA:
undetectable		 5xioA-3s9jA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 THR A  67
GLU A 220
HIS A 218
 None
 0.85A 5xioA-3sp1A:
undetectable		 5xioA-3sp1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 THR A 306
GLU A 387
HIS A 453
 None
 0.92A 5xioA-3u3iA:
undetectable		 5xioA-3u3iA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		3 THR A 121
GLU A 124
HIS A 183
 None
None
SO4  A 904 ( 3.8A)
 0.67A 5xioA-3vmwA:
undetectable		 5xioA-3vmwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		3 THR A  97
GLU A 241
HIS A 234
 None
 0.91A 5xioA-3vscA:
2.7		 5xioA-3vscA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 THR A  98
GLU A  91
HIS A 236
 None
 0.81A 5xioA-3vueA:
3.1		 5xioA-3vueA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		3 THR A  14
GLU A 159
HIS A 152
 None
None
PLP  A 401 ( 4.9A)
 0.90A 5xioA-3x43A:
undetectable		 5xioA-3x43A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		3 THR A  14
GLU A 161
HIS A 154
 None
 0.89A 5xioA-3zeiA:
undetectable		 5xioA-3zeiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		3 THR A 277
GLU A 275
HIS A 182
 None
None
ZN  A1364 ( 3.5A)
 0.79A 5xioA-3zwfA:
undetectable		 5xioA-3zwfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 3 THR A 180
GLU A 340
HIS A  44
 None
 0.87A 5xioA-4bpsA:
undetectable		 5xioA-4bpsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF05207
(zf-CSL) 		3 THR A 230
GLU A 271
HIS A 250
 None
 0.79A 5xioA-4d4pA:
undetectable		 5xioA-4d4pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 THR A 288
GLU A 189
HIS A 146
 None
None
CTT  A 401 (-3.7A)
 0.89A 5xioA-4hu0A:
undetectable		 5xioA-4hu0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		3 THR A  96
GLU A  13
HIS A  34
 None
None
PO4  A 400 (-3.9A)
 0.63A 5xioA-4hwgA:
3.6		 5xioA-4hwgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		3 THR A  24
GLU A 175
HIS A 169
 None
 0.89A 5xioA-4il5A:
undetectable		 5xioA-4il5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 THR A 503
GLU A 499
HIS A 428
 None
 0.67A 5xioA-4ktpA:
undetectable		 5xioA-4ktpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		3 THR X  14
GLU X 160
HIS X 153
 None
 0.88A 5xioA-4li3X:
undetectable		 5xioA-4li3X:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lma CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		3 THR A  14
GLU A 164
HIS A 157
 None
None
PLP  A 403 ( 4.9A)
 0.93A 5xioA-4lmaA:
undetectable		 5xioA-4lmaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		3 THR A  14
GLU A 164
HIS A 157
 None
None
PLP  A 403 ( 4.9A)
 0.92A 5xioA-4lmbA:
2.3		 5xioA-4lmbA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		3 THR A  38
GLU A 354
HIS A 340
 None
None
MN  A 501 (-3.2A)
 0.89A 5xioA-4n7tA:
undetectable		 5xioA-4n7tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		3 THR A 308
GLU A 300
HIS A 304
 None
 0.91A 5xioA-4rl1A:
undetectable		 5xioA-4rl1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 THR A 361
GLU A 236
HIS A 194
 None
 0.87A 5xioA-4w87A:
undetectable		 5xioA-4w87A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		3 THR B 230
GLU B 271
HIS B 250
 None
None
CL  A 102 ( 4.8A)
 0.84A 5xioA-4x33B:
undetectable		 5xioA-4x33B:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A 359
GLU A 361
HIS A 480
 HFG  A 802 (-3.2A)
HFG  A 802 (-2.9A)
HFG  A 802 (-4.0A)
 0.13A 5xioA-4ydqA:
50.6		 5xioA-4ydqA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		3 THR A 333
GLU A 449
HIS A 442
 None
 0.81A 5xioA-4ye9A:
undetectable		 5xioA-4ye9A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7j SWITCH-ACTIVATING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 3 THR A  30
GLU A  36
HIS A  76
 None
 0.72A 5xioA-5b7jA:
undetectable		 5xioA-5b7jA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 THR A 814
GLU A 806
HIS A 810
 None
 0.92A 5xioA-5bp1A:
2.5		 5xioA-5bp1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		3 THR A 152
GLU A 409
HIS A 408
 None
 0.83A 5xioA-5e78A:
undetectable		 5xioA-5e78A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 THR A 284
GLU A 184
HIS A 149
 None
 0.90A 5xioA-5ecuA:
undetectable		 5xioA-5ecuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		3 THR A 208
GLU A 206
HIS A 152
 A  C   1 ( 4.4A)
None
None
 0.74A 5xioA-5habA:
undetectable		 5xioA-5habA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		3 THR A 198
GLU A 193
HIS A 120
 None
 0.79A 5xioA-5i77A:
undetectable		 5xioA-5i77A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		3 THR A 173
GLU A 108
HIS A 146
 None
None
BEZ  A 401 ( 4.2A)
 0.88A 5xioA-5im2A:
undetectable		 5xioA-5im2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		3 THR A  12
GLU A 166
HIS A 159
 None
 0.91A 5xioA-5jjcA:
undetectable		 5xioA-5jjcA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 THR A 297
GLU A 278
HIS A 166
 None
 0.88A 5xioA-5mp7A:
undetectable		 5xioA-5mp7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Aspergillus
fumigatus) 		PF01487
(DHquinase_I) 		3 THR A1122
GLU A1155
HIS A1179
 None
 0.62A 5xioA-5swuA:
undetectable		 5xioA-5swuA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 THR A 180
GLU A 319
HIS A  68
 None
 0.66A 5xioA-5tnxA:
3.3		 5xioA-5tnxA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		3 THR A 131
GLU A 293
HIS A 289
 None
 0.68A 5xioA-5uibA:
4.7		 5xioA-5uibA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 THR A1121
GLU A1123
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 (-4.1A)
 0.51A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 3 THR A 283
GLU A 192
HIS A 156
 None
 0.93A 5xioA-5wh8A:
undetectable		 5xioA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		3 THR A  14
GLU A 160
HIS A 153
 None
 0.89A 5xioA-5xa2A:
undetectable		 5xioA-5xa2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 3 THR A 439
GLU A 441
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.7A)
 0.07A 5xioA-5xiiA:
51.7		 5xioA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 3 THR A 331
GLU A 333
HIS A 452
 HFG  A 801 (-3.4A)
HFG  A 801 (-3.0A)
HFG  A 801 (-4.2A)
 0.01A 5xioA-5xioA:
60.2		 5xioA-5xioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 3 THR A 359
GLU A 361
HIS A 480
 HFG  A1003 (-3.9A)
HFG  A1003 (-2.9A)
HFG  A1003 (-3.5A)
 0.31A 5xioA-5xipA:
51.3		 5xioA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 THR B 493
GLU B 207
HIS B 511
 None
 0.78A 5xioA-5xogB:
undetectable		 5xioA-5xogB:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN

(Japanese
encephalitis
virus) 		no annotation 3 THR A 317
GLU A 373
HIS A 144
 None
 0.67A 5xioA-5ywpA:
undetectable		 5xioA-5ywpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk8 PRE-MRNA-SPLICING
FACTOR SYF1

(Saccharomyces
cerevisiae) 		no annotation 3 THR U 796
GLU U 788
HIS U 791
 None
 0.90A 5xioA-6bk8U:
undetectable		 5xioA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 3 THR A  21
GLU A 174
HIS A 167
 None
 0.91A 5xioA-6c2hA:
2.6		 5xioA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 THR A 138
GLU A 496
HIS A 437
 None
 0.73A 5xioA-6evgA:
undetectable		 5xioA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 THR A 138
GLU A 496
HIS A 439
 None
None
EDO  A 602 (-3.8A)
 0.82A 5xioA-6evgA:
undetectable		 5xioA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 THR A 138
GLU A 496
HIS A 491
 None
 0.88A 5xioA-6evgA:
undetectable		 5xioA-6evgA:
undetectable