SIMILAR PATTERNS OF AMINO ACIDS FOR 5XDX_W_CHDW101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI

(Mycoplasma) 		PF11407
(RestrictionMunI) 		4 ILE A  86
LEU A  42
PHE A  35
LEU A 189
 None
 0.90A 5xdxN-1d02A:
undetectable
5xdxW-1d02A:
undetectable		 5xdxN-1d02A:
17.47
5xdxW-1d02A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.72A 5xdxN-1harA:
undetectable
5xdxW-1harA:
0.0		 5xdxN-1harA:
18.00
5xdxW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 LEU A 500
PHE A 495
ARG A 336
THR A 159
 None
None
DAD  A 601 (-3.2A)
None
 0.89A 5xdxN-1kejA:
0.0
5xdxW-1kejA:
0.0		 5xdxN-1kejA:
19.85
5xdxW-1kejA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.86A 5xdxN-1kt8A:
0.0
5xdxW-1kt8A:
0.0		 5xdxN-1kt8A:
22.71
5xdxW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2m REP PROTEIN

(Tomato yellow
leaf curl
Sardinia virus) 		PF00799
(Gemini_AL1) 		4 ILE A   9
PHE A   7
THR A  17
LEU A  16
 None
 0.83A 5xdxN-1l2mA:
0.0
5xdxW-1l2mA:
undetectable		 5xdxN-1l2mA:
10.72
5xdxW-1l2mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 106
MET A 210
THR A 211
LEU A 214
 HEM  A1407 (-4.5A)
None
None
None
 0.88A 5xdxN-1odoA:
0.1
5xdxW-1odoA:
0.0		 5xdxN-1odoA:
23.13
5xdxW-1odoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.82A 5xdxN-1skaA:
0.0
5xdxW-1skaA:
0.0		 5xdxN-1skaA:
19.89
5xdxW-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		4 ILE A 216
LEU A  10
ARG A 180
LEU A 130
 None
 0.94A 5xdxN-1vlpA:
0.0
5xdxW-1vlpA:
0.0		 5xdxN-1vlpA:
20.47
5xdxW-1vlpA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.86A 5xdxN-1wqlB:
undetectable
5xdxW-1wqlB:
0.0		 5xdxN-1wqlB:
16.39
5xdxW-1wqlB:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysp TRANSCRIPTIONAL
REGULATOR KDGR

(Escherichia
coli) 		PF01614
(IclR) 		4 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.90A 5xdxN-1yspA:
undetectable
5xdxW-1yspA:
undetectable		 5xdxN-1yspA:
15.37
5xdxW-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.93A 5xdxN-1zv4X:
0.0
5xdxW-1zv4X:
undetectable		 5xdxN-1zv4X:
13.67
5xdxW-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 5xdxN-2eg5A:
0.0
5xdxW-2eg5A:
undetectable		 5xdxN-2eg5A:
22.14
5xdxW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.90A 5xdxN-2ho5A:
undetectable
5xdxW-2ho5A:
undetectable		 5xdxN-2ho5A:
20.46
5xdxW-2ho5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A  89
ARG A  28
THR A  31
LEU A  33
 None
 0.91A 5xdxN-2j3zA:
undetectable
5xdxW-2j3zA:
undetectable		 5xdxN-2j3zA:
19.36
5xdxW-2j3zA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 ILE A   3
LEU A 114
PHE A 111
LEU A  65
 None
 0.86A 5xdxN-2jznA:
undetectable
5xdxW-2jznA:
undetectable		 5xdxN-2jznA:
15.94
5xdxW-2jznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.88A 5xdxN-2la7A:
undetectable
5xdxW-2la7A:
undetectable		 5xdxN-2la7A:
14.14
5xdxW-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 ILE A  53
PHE A  79
THR A  97
LEU A  95
 None
 0.92A 5xdxN-2o6qA:
undetectable
5xdxW-2o6qA:
undetectable		 5xdxN-2o6qA:
18.29
5xdxW-2o6qA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 324
ARG A 365
THR A 342
LEU A 341
 None
 0.90A 5xdxN-2omvA:
undetectable
5xdxW-2omvA:
undetectable		 5xdxN-2omvA:
22.56
5xdxW-2omvA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.76A 5xdxN-2p0dA:
undetectable
5xdxW-2p0dA:
undetectable		 5xdxN-2p0dA:
12.67
5xdxW-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.80A 5xdxN-2p3gX:
undetectable
5xdxW-2p3gX:
undetectable		 5xdxN-2p3gX:
19.81
5xdxW-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A 272
PHE A 203
THR A  16
LEU A  17
 None
 0.88A 5xdxN-2qk4A:
undetectable
5xdxW-2qk4A:
undetectable		 5xdxN-2qk4A:
22.52
5xdxW-2qk4A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.93A 5xdxN-2uvfA:
undetectable
5xdxW-2uvfA:
undetectable		 5xdxN-2uvfA:
22.56
5xdxW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 363
LEU A 342
PHE A 341
ARG A 409
 None
 0.94A 5xdxN-2v7bA:
undetectable
5xdxW-2v7bA:
undetectable		 5xdxN-2v7bA:
21.98
5xdxW-2v7bA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 LEU 1  84
PHE 1 156
THR 1 198
LEU 1 197
 None
 0.89A 5xdxN-2ws91:
undetectable
5xdxW-2ws91:
undetectable		 5xdxN-2ws91:
19.07
5xdxW-2ws91:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 TYR J  32
MET J  36
THR J  37
LEU J  40
 None
 0.08A 5xdxN-2y69J:
undetectable
5xdxW-2y69J:
7.9		 5xdxN-2y69J:
10.31
5xdxW-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.94A 5xdxN-2zsgA:
undetectable
5xdxW-2zsgA:
undetectable		 5xdxN-2zsgA:
20.79
5xdxW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.66A 5xdxN-2ztsA:
undetectable
5xdxW-2ztsA:
undetectable		 5xdxN-2ztsA:
17.81
5xdxW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ILE A 343
LEU A 347
PHE A 344
LEU A 396
 None
 0.81A 5xdxN-3b46A:
undetectable
5xdxW-3b46A:
undetectable		 5xdxN-3b46A:
22.55
5xdxW-3b46A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.32A 5xdxN-3b7yA:
undetectable
5xdxW-3b7yA:
undetectable		 5xdxN-3b7yA:
13.39
5xdxW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.73A 5xdxN-3c9bA:
undetectable
5xdxW-3c9bA:
undetectable		 5xdxN-3c9bA:
16.41
5xdxW-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.86A 5xdxN-3dbyA:
1.9
5xdxW-3dbyA:
undetectable		 5xdxN-3dbyA:
17.09
5xdxW-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.74A 5xdxN-3dcpA:
undetectable
5xdxW-3dcpA:
undetectable		 5xdxN-3dcpA:
19.37
5xdxW-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		4 ILE X  25
LEU X  27
ARG X  43
LEU X  37
 None
 0.80A 5xdxN-3du1X:
undetectable
5xdxW-3du1X:
undetectable		 5xdxN-3du1X:
17.83
5xdxW-3du1X:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.80A 5xdxN-3fg4A:
undetectable
5xdxW-3fg4A:
undetectable		 5xdxN-3fg4A:
20.56
5xdxW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.91A 5xdxN-3gjuA:
undetectable
5xdxW-3gjuA:
undetectable		 5xdxN-3gjuA:
22.26
5xdxW-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.76A 5xdxN-3gzyB:
undetectable
5xdxW-3gzyB:
undetectable		 5xdxN-3gzyB:
15.34
5xdxW-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.92A 5xdxN-3ihpA:
undetectable
5xdxW-3ihpA:
undetectable		 5xdxN-3ihpA:
18.99
5xdxW-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 5xdxN-3iqdB:
undetectable
5xdxW-3iqdB:
undetectable		 5xdxN-3iqdB:
21.05
5xdxW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.87A 5xdxN-3j4pA:
undetectable
5xdxW-3j4pA:
undetectable		 5xdxN-3j4pA:
22.36
5xdxW-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 ILE A  38
LEU A 130
PHE A 131
LEU A 183
 None
 0.90A 5xdxN-3j4uA:
undetectable
5xdxW-3j4uA:
undetectable		 5xdxN-3j4uA:
21.07
5xdxW-3j4uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.74A 5xdxN-3k13A:
undetectable
5xdxW-3k13A:
undetectable		 5xdxN-3k13A:
20.20
5xdxW-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.91A 5xdxN-3kuqA:
undetectable
5xdxW-3kuqA:
undetectable		 5xdxN-3kuqA:
17.51
5xdxW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		4 ILE A  41
PHE A  37
ARG A  25
LEU A  15
 None
 0.92A 5xdxN-3majA:
undetectable
5xdxW-3majA:
undetectable		 5xdxN-3majA:
23.81
5xdxW-3majA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A 283
ARG A 298
THR A 296
LEU A 295
 None
 0.77A 5xdxN-3muuA:
undetectable
5xdxW-3muuA:
undetectable		 5xdxN-3muuA:
21.45
5xdxW-3muuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.73A 5xdxN-3ng9A:
undetectable
5xdxW-3ng9A:
undetectable		 5xdxN-3ng9A:
21.77
5xdxW-3ng9A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.91A 5xdxN-3om9A:
undetectable
5xdxW-3om9A:
undetectable		 5xdxN-3om9A:
20.12
5xdxW-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.78A 5xdxN-3p8cB:
1.5
5xdxW-3p8cB:
undetectable		 5xdxN-3p8cB:
18.35
5xdxW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.76A 5xdxN-3pf2A:
undetectable
5xdxW-3pf2A:
undetectable		 5xdxN-3pf2A:
18.65
5xdxW-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0x CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		4 LEU A 153
PHE A 155
ARG A  48
LEU A  63
 None
 0.90A 5xdxN-3q0xA:
undetectable
5xdxW-3q0xA:
2.3		 5xdxN-3q0xA:
16.90
5xdxW-3q0xA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 375
LEU A 250
ARG A 246
LEU A 318
 None
 0.77A 5xdxN-3ra2A:
undetectable
5xdxW-3ra2A:
undetectable		 5xdxN-3ra2A:
23.22
5xdxW-3ra2A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.72A 5xdxN-3rr1A:
undetectable
5xdxW-3rr1A:
undetectable		 5xdxN-3rr1A:
22.10
5xdxW-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.80A 5xdxN-3shmA:
undetectable
5xdxW-3shmA:
undetectable		 5xdxN-3shmA:
22.63
5xdxW-3shmA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u15 PROTEIN MDM4

(Homo sapiens) 		PF02201
(SWIB) 		4 ILE A  36
ARG A  87
MET A 101
LEU A 102
 None
 0.92A 5xdxN-3u15A:
undetectable
5xdxW-3u15A:
undetectable		 5xdxN-3u15A:
11.22
5xdxW-3u15A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.82A 5xdxN-3ux1A:
undetectable
5xdxW-3ux1A:
undetectable		 5xdxN-3ux1A:
22.87
5xdxW-3ux1A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		4 ILE A 191
LEU A 186
THR A  23
LEU A  22
 None
 0.90A 5xdxN-3v85A:
undetectable
5xdxW-3v85A:
undetectable		 5xdxN-3v85A:
17.05
5xdxW-3v85A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		4 LEU A  68
ARG A 164
THR A 105
LEU A 106
 None
 0.93A 5xdxN-3wa8A:
undetectable
5xdxW-3wa8A:
undetectable		 5xdxN-3wa8A:
13.36
5xdxW-3wa8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.83A 5xdxN-4b8cD:
undetectable
5xdxW-4b8cD:
undetectable		 5xdxN-4b8cD:
21.05
5xdxW-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjt DNA-BINDING PROTEIN
RAP1

(Saccharomyces
cerevisiae) 		PF11626
(Rap1_C) 		4 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.91A 5xdxN-4bjtA:
undetectable
5xdxW-4bjtA:
undetectable		 5xdxN-4bjtA:
18.11
5xdxW-4bjtA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  78
MET A  92
THR A  93
LEU A 160
 None
 0.80A 5xdxN-4bobA:
undetectable
5xdxW-4bobA:
undetectable		 5xdxN-4bobA:
15.65
5xdxW-4bobA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.80A 5xdxN-4bxmA:
undetectable
5xdxW-4bxmA:
undetectable		 5xdxN-4bxmA:
15.42
5xdxW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ILE B 116
LEU B 135
THR B 111
LEU B 109
 None
 0.87A 5xdxN-4htfB:
undetectable
5xdxW-4htfB:
undetectable		 5xdxN-4htfB:
18.97
5xdxW-4htfB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ILE A  93
LEU A  99
ARG A 109
LEU A  81
 None
 0.83A 5xdxN-4i9fA:
undetectable
5xdxW-4i9fA:
undetectable		 5xdxN-4i9fA:
20.93
5xdxW-4i9fA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 LEU A 275
ARG A 303
MET A 307
LEU A 308
 None
 0.69A 5xdxN-4kemA:
undetectable
5xdxW-4kemA:
undetectable		 5xdxN-4kemA:
21.75
5xdxW-4kemA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE B 512
LEU B 537
PHE B 558
LEU B 452
 None
 0.92A 5xdxN-4l37B:
undetectable
5xdxW-4l37B:
undetectable		 5xdxN-4l37B:
18.83
5xdxW-4l37B:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1a HYPOTHETICAL PROTEIN

(Sebaldella
termitidis) 		PF08921
(DUF1904) 		4 ILE A  73
PHE A  77
ARG A   5
THR A  37
 None
 0.81A 5xdxN-4m1aA:
undetectable
5xdxW-4m1aA:
undetectable		 5xdxN-4m1aA:
12.03
5xdxW-4m1aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjd KETOSTEROID
ISOMERASE FOLD
PROTEIN HMUK_0747

(Halomicrobium
mukohataei) 		PF12680
(SnoaL_2) 		4 ILE A 100
LEU A  26
ARG A   8
LEU A  14
 None
 0.90A 5xdxN-4mjdA:
undetectable
5xdxW-4mjdA:
undetectable		 5xdxN-4mjdA:
12.00
5xdxW-4mjdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 ILE A 272
LEU A 326
PHE A 325
THR A 303
 None
 0.92A 5xdxN-4o5pA:
0.5
5xdxW-4o5pA:
undetectable		 5xdxN-4o5pA:
19.53
5xdxW-4o5pA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 662
LEU A 683
THR A 674
LEU A 672
 None
 0.70A 5xdxN-4om9A:
undetectable
5xdxW-4om9A:
undetectable		 5xdxN-4om9A:
19.71
5xdxW-4om9A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.82A 5xdxN-4oqfA:
undetectable
5xdxW-4oqfA:
undetectable		 5xdxN-4oqfA:
20.15
5xdxW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 4 ILE A 130
PHE A  91
ARG A  72
LEU A  86
 None
 0.89A 5xdxN-4rw3A:
undetectable
5xdxW-4rw3A:
undetectable		 5xdxN-4rw3A:
20.23
5xdxW-4rw3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 4 ARG C 309
MET C 312
THR C 313
LEU C 316
 None
 0.90A 5xdxN-4rwtC:
undetectable
5xdxW-4rwtC:
undetectable		 5xdxN-4rwtC:
19.44
5xdxW-4rwtC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.92A 5xdxN-4w8pB:
undetectable
5xdxW-4w8pB:
undetectable		 5xdxN-4w8pB:
6.75
5xdxW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynh SPINDLE ASSEMBLY
ABNORMAL PROTEIN 5

(Caenorhabditis
elegans) 		no annotation 4 ILE A 247
LEU A 237
PHE A 243
LEU A 230
 None
 0.76A 5xdxN-4ynhA:
undetectable
5xdxW-4ynhA:
undetectable		 5xdxN-4ynhA:
8.11
5xdxW-4ynhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ILE A 484
LEU A 491
PHE A 452
LEU A 440
 None
 0.92A 5xdxN-5a5tA:
undetectable
5xdxW-5a5tA:
undetectable		 5xdxN-5a5tA:
13.37
5xdxW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 ILE A 388
PHE A 387
ARG A 454
THR A 333
 None
 0.91A 5xdxN-5c65A:
0.6
5xdxW-5c65A:
undetectable		 5xdxN-5c65A:
24.43
5xdxW-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.82A 5xdxN-5c9eA:
2.4
5xdxW-5c9eA:
undetectable		 5xdxN-5c9eA:
19.39
5xdxW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 LEU A 430
ARG A  37
THR A 464
LEU A 463
 None
 0.92A 5xdxN-5e7pA:
undetectable
5xdxW-5e7pA:
undetectable		 5xdxN-5e7pA:
22.32
5xdxW-5e7pA:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.90A 5xdxN-5ed8A:
undetectable
5xdxW-5ed8A:
undetectable		 5xdxN-5ed8A:
19.08
5xdxW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		4 ILE A  72
PHE A  63
ARG A  79
THR A  81
 None
 0.85A 5xdxN-5edjA:
undetectable
5xdxW-5edjA:
undetectable		 5xdxN-5edjA:
16.42
5xdxW-5edjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzy (R)-2-HALOACID
DEHALOGENASE

(Pseudomonas
putida) 		PF10778
(DehI) 		4 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.83A 5xdxN-5gzyA:
1.1
5xdxW-5gzyA:
undetectable		 5xdxN-5gzyA:
20.49
5xdxW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.88A 5xdxN-5i2qA:
undetectable
5xdxW-5i2qA:
undetectable		 5xdxN-5i2qA:
11.61
5xdxW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.83A 5xdxN-5idiA:
undetectable
5xdxW-5idiA:
undetectable		 5xdxN-5idiA:
21.38
5xdxW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.73A 5xdxN-5j6sA:
undetectable
5xdxW-5j6sA:
undetectable		 5xdxN-5j6sA:
20.29
5xdxW-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 ILE B  23
LEU B  48
THR B  33
LEU B  34
 None
 0.72A 5xdxN-5jw7B:
undetectable
5xdxW-5jw7B:
undetectable		 5xdxN-5jw7B:
10.76
5xdxW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 ILE A 703
LEU A 700
THR A  82
LEU A  81
 None
 0.84A 5xdxN-5jwfA:
1.0
5xdxW-5jwfA:
undetectable		 5xdxN-5jwfA:
20.60
5xdxW-5jwfA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ILE A 700
LEU A 697
THR A  82
LEU A  81
 None
 0.80A 5xdxN-5jxkA:
2.0
5xdxW-5jxkA:
undetectable		 5xdxN-5jxkA:
18.80
5xdxW-5jxkA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 LEU A 286
ARG A 277
THR A 275
LEU A 274
 None
 0.83A 5xdxN-5k9tA:
undetectable
5xdxW-5k9tA:
undetectable		 5xdxN-5k9tA:
21.11
5xdxW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 PHE A 206
ARG A 186
THR A 168
LEU A 167
 None
 0.83A 5xdxN-5mhfA:
undetectable
5xdxW-5mhfA:
undetectable		 5xdxN-5mhfA:
undetectable
5xdxW-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 155
LEU A 158
THR A 370
LEU A 175
 None
 0.78A 5xdxN-5mqmA:
undetectable
5xdxW-5mqmA:
undetectable		 5xdxN-5mqmA:
19.15
5xdxW-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 4 PHE G  86
MET G 100
THR G 101
LEU G 166
 None
 0.86A 5xdxN-5nbqG:
undetectable
5xdxW-5nbqG:
undetectable		 5xdxN-5nbqG:
undetectable
5xdxW-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 163
ARG A 149
MET A 604
LEU A 600
 None
 0.88A 5xdxN-5nqdA:
undetectable
5xdxW-5nqdA:
undetectable		 5xdxN-5nqdA:
undetectable
5xdxW-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ILE A 427
MET A 477
THR A 476
LEU A 475
 None
 0.81A 5xdxN-5ny0A:
undetectable
5xdxW-5ny0A:
undetectable		 5xdxN-5ny0A:
undetectable
5xdxW-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE B 127
PHE B 147
THR B 300
LEU B 299
 None
 0.85A 5xdxN-5tpwB:
undetectable
5xdxW-5tpwB:
undetectable		 5xdxN-5tpwB:
20.58
5xdxW-5tpwB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob ENVELOPE
GLYCOPROTEIN UL128

(Human
betaherpesvirus
5) 		no annotation 4 ILE C 109
LEU C 103
THR C  85
LEU C  84
 None
 0.86A 5xdxN-5vobC:
undetectable
5xdxW-5vobC:
undetectable		 5xdxN-5vobC:
14.92
5xdxW-5vobC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 243
TYR A  76
ARG A  78
LEU A 591
 None
 0.90A 5xdxN-5wugA:
undetectable
5xdxW-5wugA:
undetectable		 5xdxN-5wugA:
undetectable
5xdxW-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 201
LEU F 221
THR F 278
LEU F 271
 None
 0.80A 5xdxN-5xagF:
undetectable
5xdxW-5xagF:
undetectable		 5xdxN-5xagF:
undetectable
5xdxW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 LEU A 538
ARG A 511
THR A 505
LEU A 550
 None
 0.89A 5xdxN-5xfaA:
2.0
5xdxW-5xfaA:
undetectable		 5xdxN-5xfaA:
22.80
5xdxW-5xfaA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ILE A  88
LEU A 167
PHE A  90
THR A  59
 None
 0.76A 5xdxN-5xu1A:
undetectable
5xdxW-5xu1A:
undetectable		 5xdxN-5xu1A:
undetectable
5xdxW-5xu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 4 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.82A 5xdxN-5yksA:
1.8
5xdxW-5yksA:
undetectable		 5xdxN-5yksA:
19.85
5xdxW-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20

(Homo sapiens) 		no annotation 4 LEU A   7
ARG A  80
THR A  73
LEU A  72
 None
 0.89A 5xdxN-5z4iA:
undetectable
5xdxW-5z4iA:
undetectable		 5xdxN-5z4iA:
undetectable
5xdxW-5z4iA:
undetectable