SIMILAR PATTERNS OF AMINO ACIDS FOR 5XDH_D_DAHD60_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		4 HIS A 137
ASN A  13
VAL A  84
LEU A 104
 None
GAR  A 221 (-4.1A)
None
None
 1.28A 5xdhD-1c3eA:
0.0		 5xdhD-1c3eA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4w TAB2

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H  80
ASN H  76
VAL H  71
LEU H  69
 None
 1.19A 5xdhD-1e4wH:
undetectable		 5xdhD-1e4wH:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		4 HIS A 242
MET A 119
VAL A 287
LEU A 285
 None
 1.21A 5xdhD-1e7sA:
undetectable		 5xdhD-1e7sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecw GAG POLYPROTEIN

(Simian
immunodeficiency
virus) 		PF00540
(Gag_p17) 		4 HIS A  33
ASN A  80
VAL A  84
LEU A  16
 None
 1.48A 5xdhD-1ecwA:
0.3		 5xdhD-1ecwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 HIS A 214
ASN A 245
VAL A 249
LEU A 333
 None
 1.33A 5xdhD-1m9qA:
0.0		 5xdhD-1m9qA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS

(Burkholderia
pseudomallei) 		PF01007
(IRK) 		4 HIS A 230
MET A 192
VAL A 255
LEU A 253
 None
 1.32A 5xdhD-1p7bA:
undetectable		 5xdhD-1p7bA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 MET A 138
ASN A 132
VAL A 128
LEU A 126
 None
 1.22A 5xdhD-1sqjA:
undetectable		 5xdhD-1sqjA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 MET A 138
ASN A 134
VAL A 128
LEU A 126
 None
 0.90A 5xdhD-1sqjA:
undetectable		 5xdhD-1sqjA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t04 HUZAF ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET B  81
ASN B  77
VAL B  72
LEU B  70
 None
 1.12A 5xdhD-1t04B:
undetectable		 5xdhD-1t04B:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 HIS A 378
MET A 298
ASN A 294
VAL A 223
 None
 1.50A 5xdhD-1tr1A:
0.0		 5xdhD-1tr1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 MET A 188
ASN A 192
VAL A 197
LEU A 199
 None
 0.85A 5xdhD-1vkzA:
0.1		 5xdhD-1vkzA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 MET A 188
ASN A 195
VAL A 197
LEU A 199
 None
 1.09A 5xdhD-1vkzA:
0.1		 5xdhD-1vkzA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjd FAB FRAGMENT OF
5.11A1 ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H  81
ASN H  77
VAL H  72
LEU H  70
 None
 0.87A 5xdhD-1yjdH:
undetectable		 5xdhD-1yjdH:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 MET A 369
ASN A 473
VAL A 475
LEU A 383
 None
 1.42A 5xdhD-2bs9A:
0.0		 5xdhD-2bs9A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A

(Homo sapiens) 		PF00041
(fn3) 		4 HIS A  77
MET A  57
VAL A  92
LEU A  90
 None
 1.25A 5xdhD-2crmA:
undetectable		 5xdhD-2crmA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2r GREEN-FLUORESCENT
ANTIBODY
(11G10)-HEAVY CHAIN

(Mus musculus) 		no annotation 4 MET H  80
ASN H  76
VAL H  71
LEU H  69
 None
 0.92A 5xdhD-2g2rH:
undetectable		 5xdhD-2g2rH:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 HIS A  59
MET A  84
VAL A  68
LEU A  70
 None
 1.30A 5xdhD-2gcaA:
0.0		 5xdhD-2gcaA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2

(Trypanosoma
brucei) 		PF09387
(MRP) 		4 HIS A  79
MET A 204
ASN A 159
VAL A 199
 None
 1.07A 5xdhD-2gjeA:
undetectable		 5xdhD-2gjeA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 MET A 368
ASN A 233
VAL A 231
LEU A 229
 None
 1.13A 5xdhD-2iu3A:
undetectable		 5xdhD-2iu3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn4 ARGININE/SERINE-RIC
H 2
IMMUNOGLOBULIN
G-BINDING PROTEIN G,
SPLICING FACTOR

(Homo sapiens;
Streptococcus
sp. 'group G') 		PF00076
(RRM_1)
PF01378
(IgG_binding_B) 		4 MET A 146
ASN A  77
VAL A  75
LEU A  73
 None
 1.44A 5xdhD-2kn4A:
undetectable		 5xdhD-2kn4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 HIS A 368
MET A 426
VAL A 362
LEU A 391
 HEM  A 500 (-3.8A)
None
HEM  A 500 ( 4.9A)
None
 1.35A 5xdhD-2nnjA:
0.0		 5xdhD-2nnjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0a SYNAPSIN-3

(Homo sapiens) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 HIS A 251
MET A 367
ASN A 200
VAL A 198
 None
SO4  A 702 (-2.8A)
None
None
 1.32A 5xdhD-2p0aA:
undetectable		 5xdhD-2p0aA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		4 HIS A 164
ASN A  89
VAL A 142
LEU A 134
 None
 1.23A 5xdhD-2pk3A:
undetectable		 5xdhD-2pk3A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC

(Thermotoga
maritima) 		PF01558
(POR) 		4 HIS A  13
ASN A  57
VAL A  75
LEU A  92
 None
 1.38A 5xdhD-2raaA:
undetectable		 5xdhD-2raaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 HIS A 372
MET A 334
ASN A 406
LEU A 333
 None
None
AD0  A1617 (-3.0A)
None
 1.46A 5xdhD-2uvfA:
undetectable		 5xdhD-2uvfA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 MET A 852
ASN A 564
VAL A 876
LEU A 873
 None
 1.25A 5xdhD-2x0sA:
undetectable		 5xdhD-2x0sA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 HIS A 120
ASN A   6
VAL A 116
LEU A 124
 3CD  A 600 (-4.1A)
3CD  A 600 ( 4.3A)
None
None
 1.47A 5xdhD-2xf8A:
undetectable		 5xdhD-2xf8A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 HIS A 420
MET A 426
ASN A 398
VAL A 400
 None
 1.40A 5xdhD-2zwaA:
undetectable		 5xdhD-2zwaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		4 HIS A 184
MET A 175
VAL A 266
LEU A 171
 None
 1.30A 5xdhD-3b59A:
undetectable		 5xdhD-3b59A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 144
MET A  67
ASN A  74
VAL A  76
 None
 1.41A 5xdhD-3dakA:
undetectable		 5xdhD-3dakA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 MET A 124
ASN A  70
VAL A  68
LEU A  66
 None
 1.15A 5xdhD-3dbiA:
undetectable		 5xdhD-3dbiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 HIS A 490
ASN A 471
VAL A 312
LEU A   8
 None
 1.02A 5xdhD-3e2dA:
undetectable		 5xdhD-3e2dA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 MET A 402
ASN A  76
VAL A  78
LEU A 414
 None
 1.28A 5xdhD-3h5cA:
undetectable		 5xdhD-3h5cA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 MET A 595
ASN A 327
VAL A 335
LEU A 502
 None
 1.40A 5xdhD-3i6sA:
undetectable		 5xdhD-3i6sA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 MET A 530
ASN A 537
VAL A 535
LEU A 531
 None
 1.42A 5xdhD-3igoA:
undetectable		 5xdhD-3igoA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		no annotation 4 MET C 219
ASN C 215
VAL C  64
LEU C  62
 None
 1.16A 5xdhD-3mh9C:
undetectable		 5xdhD-3mh9C:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		4 MET A 219
ASN A 215
VAL A  64
LEU A  62
 Z69  A   1 (-4.2A)
None
None
Z69  A   1 ( 4.8A)
 1.15A 5xdhD-3mhaA:
undetectable		 5xdhD-3mhaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 MET A 260
ASN A 256
VAL A 253
LEU A 251
 None
 1.20A 5xdhD-3n6xA:
undetectable		 5xdhD-3n6xA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		4 MET A 701
ASN A 709
VAL A 704
LEU A 698
 None
 1.25A 5xdhD-3nmzA:
undetectable		 5xdhD-3nmzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 MET A  77
ASN A 135
VAL A 137
LEU A 120
 None
 1.15A 5xdhD-3vbjA:
undetectable		 5xdhD-3vbjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		4 HIS A 486
ASN A 467
VAL A 308
LEU A   8
 None
 1.09A 5xdhD-3wbhA:
undetectable		 5xdhD-3wbhA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt2 PROTEIN
DISULFIDE-ISOMERASE

(Humicola
insolens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 HIS A 270
ASN A 292
VAL A 289
LEU A 228
 None
 1.47A 5xdhD-3wt2A:
undetectable		 5xdhD-3wt2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 MET A 146
ASN A 428
VAL A 170
LEU A 168
 None
 1.36A 5xdhD-4ewjA:
undetectable		 5xdhD-4ewjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 HIS B 251
ASN B 160
VAL B 157
LEU B 155
 None
 1.47A 5xdhD-4g7eB:
undetectable		 5xdhD-4g7eB:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 HIS A 443
MET A 426
ASN A 436
LEU A 407
 None
 1.39A 5xdhD-4i5jA:
undetectable		 5xdhD-4i5jA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id0 GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF

(Pseudomonas
fluorescens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 HIS A  20
ASN A  26
VAL A  28
LEU A  30
 None
 1.35A 5xdhD-4id0A:
undetectable		 5xdhD-4id0A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 HIS A 347
ASN A 355
VAL A 342
LEU A 383
 None
 1.48A 5xdhD-4ofzA:
undetectable		 5xdhD-4ofzA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 HIS A 230
ASN A 172
VAL A 169
LEU A 167
 None
2UF  A 401 (-3.9A)
None
None
 1.35A 5xdhD-4pbqA:
undetectable		 5xdhD-4pbqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E
TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus) 		PF00437
(T2SSE)
PF05134
(T2SSL) 		4 HIS X 162
MET X 175
ASN A  44
LEU X 179
 None
 1.38A 5xdhD-4phtX:
undetectable		 5xdhD-4phtX:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		4 HIS A 446
ASN A 275
VAL A 273
LEU A 456
 None
FAD  A 501 (-3.1A)
None
None
 1.42A 5xdhD-4repA:
undetectable		 5xdhD-4repA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 4 HIS A  74
MET A 293
VAL A  90
LEU A  88
 None
 1.06A 5xdhD-4rkmA:
undetectable		 5xdhD-4rkmA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		4 MET A 701
ASN A 709
VAL A 704
LEU A 698
 None
 1.31A 5xdhD-4yk6A:
undetectable		 5xdhD-4yk6A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2

(Rattus
norvegicus) 		no annotation 4 HIS A 451
ASN A 420
VAL A 428
LEU A 439
 None
 1.39A 5xdhD-5a9iA:
undetectable		 5xdhD-5a9iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 4 HIS A1640
ASN A1573
VAL A1571
LEU A1631
 None
 1.37A 5xdhD-5cwuA:
undetectable		 5xdhD-5cwuA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 HIS B 109
ASN B 181
VAL B 179
LEU B 168
 None
 1.50A 5xdhD-5do8B:
undetectable		 5xdhD-5do8B:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		4 HIS A  20
ASN A  17
VAL A  97
LEU A  55
 None
 1.36A 5xdhD-5dxxA:
undetectable		 5xdhD-5dxxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG

(Microbacterium
sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 HIS A 138
ASN A 111
VAL A 113
LEU A 135
 None
 1.20A 5xdhD-5h1aA:
undetectable		 5xdhD-5h1aA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 HIS C 131
ASN C 123
VAL C 121
LEU C  99
 None
 1.34A 5xdhD-5ip7C:
undetectable		 5xdhD-5ip7C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iww PLS9-PPR

(unidentified) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		4 HIS D 277
MET D 298
VAL D 291
LEU D 261
 None
 1.28A 5xdhD-5iwwD:
undetectable		 5xdhD-5iwwD:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 MET A 671
ASN A 651
VAL A 646
LEU A 673
 None
 1.10A 5xdhD-5jqkA:
undetectable		 5xdhD-5jqkA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 HIS A 630
ASN A 654
VAL A 619
LEU A 597
 HIS  A 630 ( 1.0A)
ASN  A 654 ( 0.6A)
VAL  A 619 ( 0.6A)
LEU  A 597 ( 0.5A)
 1.38A 5xdhD-5l5nA:
undetectable		 5xdhD-5l5nA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 4 MET A 414
ASN A 410
VAL A  10
LEU A   8
 None
 1.18A 5xdhD-5suiA:
undetectable		 5xdhD-5suiA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tud ANTI-5-HT2B FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET C  81
ASN C  77
VAL C  72
LEU C  70
 None
 1.19A 5xdhD-5tudC:
undetectable		 5xdhD-5tudC:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 MET B 480
ASN B 473
VAL B 468
LEU B 466
 None
 1.46A 5xdhD-5vljB:
undetectable		 5xdhD-5vljB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		no annotation 4 HIS C 131
ASN C 123
VAL C 121
LEU C  99
 None
 1.47A 5xdhD-5w4uC:
undetectable		 5xdhD-5w4uC:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 4 HIS A  10
ASN A 116
VAL A  77
LEU A  86
 ZN  A 502 (-3.3A)
None
None
None
 1.44A 5xdhD-5zb8A:
undetectable		 5xdhD-5zb8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 4 HIS A 155
MET A 220
ASN A 173
LEU A 224
 None
 1.19A 5xdhD-6c8zA:
undetectable		 5xdhD-6c8zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1e INTERFERON GAMMA

(Paralichthys
olivaceus) 		no annotation 4 HIS A  40
MET A  85
ASN A  91
LEU A 116
 None
 1.10A 5xdhD-6f1eA:
undetectable		 5xdhD-6f1eA:
21.18