SIMILAR PATTERNS OF AMINO ACIDS FOR 5XDH_B_DAHB60

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		4 HIS A 137
ASN A  13
VAL A  84
LEU A 104
 None
GAR  A 221 (-4.1A)
None
None
 1.25A 5xdhB-1c3eA:
undetectable		 5xdhB-1c3eA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4w TAB2

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H  80
ASN H  76
VAL H  71
LEU H  69
 None
 1.17A 5xdhB-1e4wH:
undetectable		 5xdhB-1e4wH:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		4 HIS A 242
MET A 119
VAL A 287
LEU A 285
 None
 1.33A 5xdhB-1e7sA:
0.0		 5xdhB-1e7sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS

(Burkholderia
pseudomallei) 		PF01007
(IRK) 		4 HIS A 230
MET A 192
VAL A 255
LEU A 253
 None
 1.31A 5xdhB-1p7bA:
undetectable		 5xdhB-1p7bA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 MET A 138
ASN A 132
VAL A 128
LEU A 126
 None
 1.38A 5xdhB-1sqjA:
undetectable		 5xdhB-1sqjA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 MET A 138
ASN A 134
VAL A 128
LEU A 126
 None
 1.10A 5xdhB-1sqjA:
undetectable		 5xdhB-1sqjA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t04 HUZAF ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET B  81
ASN B  77
VAL B  72
LEU B  70
 None
 1.09A 5xdhB-1t04B:
undetectable		 5xdhB-1t04B:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 MET A 188
ASN A 192
VAL A 197
LEU A 199
 None
 0.90A 5xdhB-1vkzA:
0.2		 5xdhB-1vkzA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 MET A 188
ASN A 195
VAL A 197
LEU A 199
 None
 1.26A 5xdhB-1vkzA:
0.2		 5xdhB-1vkzA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjd FAB FRAGMENT OF
5.11A1 ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H  81
ASN H  77
VAL H  72
LEU H  70
 None
 0.82A 5xdhB-1yjdH:
undetectable		 5xdhB-1yjdH:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A

(Homo sapiens) 		PF00041
(fn3) 		4 HIS A  77
MET A  57
VAL A  92
LEU A  90
 None
 1.21A 5xdhB-2crmA:
undetectable		 5xdhB-2crmA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2r GREEN-FLUORESCENT
ANTIBODY
(11G10)-HEAVY CHAIN

(Mus musculus) 		no annotation 4 MET H  80
ASN H  76
VAL H  71
LEU H  69
 None
 0.92A 5xdhB-2g2rH:
undetectable		 5xdhB-2g2rH:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2

(Trypanosoma
brucei) 		PF09387
(MRP) 		4 HIS A  79
MET A 204
ASN A 159
VAL A 199
 None
 1.14A 5xdhB-2gjeA:
undetectable		 5xdhB-2gjeA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 MET A 368
ASN A 233
VAL A 231
LEU A 229
 None
 1.34A 5xdhB-2iu3A:
undetectable		 5xdhB-2iu3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 HIS A 132
MET A 222
ASN A 362
LEU A 174
 None
 1.38A 5xdhB-2nyfA:
0.0		 5xdhB-2nyfA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		4 HIS A 164
ASN A  89
VAL A 142
LEU A 134
 None
 1.24A 5xdhB-2pk3A:
0.0		 5xdhB-2pk3A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC

(Thermotoga
maritima) 		PF01558
(POR) 		4 HIS A  13
ASN A  57
VAL A  75
LEU A  92
 None
 1.35A 5xdhB-2raaA:
0.0		 5xdhB-2raaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 HIS A 372
MET A 334
ASN A 406
LEU A 333
 None
None
AD0  A1617 (-3.0A)
None
 1.38A 5xdhB-2uvfA:
0.0		 5xdhB-2uvfA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 MET A 852
ASN A 564
VAL A 876
LEU A 873
 None
 1.31A 5xdhB-2x0sA:
0.5		 5xdhB-2x0sA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		4 HIS A 184
MET A 175
VAL A 266
LEU A 171
 None
 1.40A 5xdhB-3b59A:
undetectable		 5xdhB-3b59A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 MET A 124
ASN A  70
VAL A  68
LEU A  66
 None
 1.33A 5xdhB-3dbiA:
0.0		 5xdhB-3dbiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 HIS A 490
ASN A 471
VAL A 312
LEU A   8
 None
 0.91A 5xdhB-3e2dA:
undetectable		 5xdhB-3e2dA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 MET A 402
ASN A  76
VAL A  78
LEU A 414
 None
 1.29A 5xdhB-3h5cA:
undetectable		 5xdhB-3h5cA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 MET A 595
ASN A 327
VAL A 335
LEU A 502
 None
 1.50A 5xdhB-3i6sA:
undetectable		 5xdhB-3i6sA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 MET A 530
ASN A 537
VAL A 535
LEU A 531
 None
 1.41A 5xdhB-3igoA:
undetectable		 5xdhB-3igoA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		no annotation 4 MET C 219
ASN C 215
VAL C  64
LEU C  62
 None
 1.32A 5xdhB-3mh9C:
undetectable		 5xdhB-3mh9C:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		4 MET A 219
ASN A 215
VAL A  64
LEU A  62
 Z69  A   1 (-4.2A)
None
None
Z69  A   1 ( 4.8A)
 1.32A 5xdhB-3mhaA:
undetectable		 5xdhB-3mhaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 MET A 260
ASN A 256
VAL A 253
LEU A 251
 None
 1.11A 5xdhB-3n6xA:
undetectable		 5xdhB-3n6xA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		4 MET A 701
ASN A 709
VAL A 704
LEU A 698
 None
 1.36A 5xdhB-3nmzA:
undetectable		 5xdhB-3nmzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE

(Entamoeba
histolytica) 		PF00145
(DNA_methylase) 		4 MET A 313
ASN A 125
VAL A 170
LEU A 316
 None
 1.42A 5xdhB-3qv2A:
undetectable		 5xdhB-3qv2A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tih HIV-1 CLADE C
ZM109F.PB4 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 HIS A 374
ASN A 377
VAL A 255
LEU A 260
 None
 1.40A 5xdhB-3tihA:
undetectable		 5xdhB-3tihA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 MET A  77
ASN A 135
VAL A 137
LEU A 120
 None
 1.24A 5xdhB-3vbjA:
undetectable		 5xdhB-3vbjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		4 HIS A 486
ASN A 467
VAL A 308
LEU A   8
 None
 0.97A 5xdhB-3wbhA:
undetectable		 5xdhB-3wbhA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 HIS A 443
MET A 426
ASN A 436
LEU A 407
 None
 1.25A 5xdhB-4i5jA:
undetectable		 5xdhB-4i5jA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 HIS A  53
ASN A  49
VAL A  26
LEU A  68
 None
 1.50A 5xdhB-4ineA:
undetectable		 5xdhB-4ineA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1

(Homo sapiens) 		PF05641
(Agenet) 		4 HIS A 188
MET A 140
VAL A 133
LEU A 137
 None
 1.49A 5xdhB-4ovaA:
undetectable		 5xdhB-4ovaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 HIS A 230
ASN A 172
VAL A 169
LEU A 167
 None
2UF  A 401 (-3.9A)
None
None
 1.29A 5xdhB-4pbqA:
undetectable		 5xdhB-4pbqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 4 HIS A  74
MET A 293
VAL A  90
LEU A  88
 None
 1.13A 5xdhB-4rkmA:
undetectable		 5xdhB-4rkmA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		4 MET A 701
ASN A 709
VAL A 704
LEU A 698
 None
 1.35A 5xdhB-4yk6A:
undetectable		 5xdhB-4yk6A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2

(Rattus
norvegicus) 		no annotation 4 HIS A 451
ASN A 420
VAL A 428
LEU A 439
 None
 1.39A 5xdhB-5a9iA:
undetectable		 5xdhB-5a9iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 4 HIS A1640
ASN A1573
VAL A1571
LEU A1631
 None
 1.37A 5xdhB-5cwuA:
undetectable		 5xdhB-5cwuA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		4 HIS A  20
ASN A  17
VAL A  97
LEU A  55
 None
 1.32A 5xdhB-5dxxA:
undetectable		 5xdhB-5dxxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG

(Microbacterium
sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 HIS A 138
ASN A 111
VAL A 113
LEU A 135
 None
 1.25A 5xdhB-5h1aA:
undetectable		 5xdhB-5h1aA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 HIS C 131
ASN C 123
VAL C 121
LEU C  99
 None
 1.34A 5xdhB-5ip7C:
undetectable		 5xdhB-5ip7C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 MET A 671
ASN A 651
VAL A 646
LEU A 673
 None
 1.01A 5xdhB-5jqkA:
undetectable		 5xdhB-5jqkA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 MET A 305
ASN A 240
VAL A 310
LEU A 306
 None
 1.36A 5xdhB-5k94A:
undetectable		 5xdhB-5k94A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 HIS B 132
MET B 222
ASN B 362
LEU B 174
 None
 1.44A 5xdhB-5ltmB:
undetectable		 5xdhB-5ltmB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 4 MET A 414
ASN A 410
VAL A  10
LEU A   8
 None
 1.33A 5xdhB-5suiA:
undetectable		 5xdhB-5suiA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 HIS A 537
MET A 504
ASN A 555
VAL A 530
 None
 1.43A 5xdhB-5te1A:
1.0		 5xdhB-5te1A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tud ANTI-5-HT2B FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET C  81
ASN C  77
VAL C  72
LEU C  70
 None
 1.12A 5xdhB-5tudC:
undetectable		 5xdhB-5tudC:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		PF01253
(SUI1) 		4 MET A 453
ASN A 429
VAL A 433
LEU A 435
 None
 1.36A 5xdhB-5w2fA:
undetectable		 5xdhB-5w2fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		PF01253
(SUI1) 		4 MET A 453
ASN A 431
VAL A 433
LEU A 435
 None
 0.80A 5xdhB-5w2fA:
undetectable		 5xdhB-5w2fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 4 HIS A  10
ASN A 116
VAL A  77
LEU A  86
 ZN  A 502 (-3.3A)
None
None
None
 1.45A 5xdhB-5zb8A:
undetectable		 5xdhB-5zb8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 4 HIS A 155
MET A 220
ASN A 173
LEU A 224
 None
 1.45A 5xdhB-6c8zA:
undetectable		 5xdhB-6c8zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1e INTERFERON GAMMA

(Paralichthys
olivaceus) 		no annotation 4 HIS A  40
MET A  85
ASN A  91
LEU A 116
 None
 1.20A 5xdhB-6f1eA:
undetectable		 5xdhB-6f1eA:
21.18