SIMILAR PATTERNS OF AMINO ACIDS FOR 5X80_D_SALD201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 PRO A 310
GLY A 308
VAL A 288
ARG A 289
 None
FMN  A 360 (-3.5A)
None
FMN  A 360 (-2.9A)
 0.97A 5x80C-1al8A:
undetectable
5x80D-1al8A:
0.0		 5x80C-1al8A:
22.28
5x80D-1al8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 PRO A 104
GLY A  98
TYR A 101
VAL A 164
 None
 1.28A 5x80C-1e8cA:
0.0
5x80D-1e8cA:
0.0		 5x80C-1e8cA:
15.90
5x80D-1e8cA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO B 100
GLY B 100
TYR B 100
VAL B  34
 None
 0.96A 5x80C-1fn4B:
undetectable
5x80D-1fn4B:
undetectable		 5x80C-1fn4B:
19.82
5x80D-1fn4B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		4 PRO B 112
GLY B 113
TYR B  89
VAL B  80
 None
 1.23A 5x80C-1i2mB:
undetectable
5x80D-1i2mB:
undetectable		 5x80C-1i2mB:
19.10
5x80D-1i2mB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm7 BRCA1-ASSOCIATED
RING DOMAIN PROTEIN
1

(Homo sapiens) 		PF14835
(zf-RING_6) 		4 PRO B  84
GLY B  82
VAL B  75
ARG B  52
 None
 1.16A 5x80C-1jm7B:
undetectable
5x80D-1jm7B:
undetectable		 5x80C-1jm7B:
21.12
5x80D-1jm7B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum) 		PF00293
(NUDIX) 		4 PRO A  28
GLY A   6
TYR A  27
VAL A  14
 None
 1.17A 5x80C-1k26A:
undetectable
5x80D-1k26A:
undetectable		 5x80C-1k26A:
22.73
5x80D-1k26A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 PRO A 223
GLY A 227
TYR A 222
VAL A 230
 None
 1.30A 5x80C-1lrkA:
0.0
5x80D-1lrkA:
0.0		 5x80C-1lrkA:
20.12
5x80D-1lrkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		4 PRO A 434
GLY A 432
VAL A 412
ARG A 413
 None
FMN  A 570 (-3.8A)
None
FMN  A 570 (-3.9A)
 0.98A 5x80C-1ltdA:
0.0
5x80D-1ltdA:
0.0		 5x80C-1ltdA:
16.85
5x80D-1ltdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 PRO A 193
GLY A 178
TYR A 192
VAL A 181
 None
 1.29A 5x80C-1ms8A:
undetectable
5x80D-1ms8A:
undetectable		 5x80C-1ms8A:
14.04
5x80D-1ms8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od5 GLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		4 PRO A 169
GLY A 167
TYR A 164
VAL A 204
 None
 1.24A 5x80C-1od5A:
0.0
5x80D-1od5A:
0.0		 5x80C-1od5A:
13.62
5x80D-1od5A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puo MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 2, CHAIN 1

(Felis catus) 		PF01099
(Uteroglobin)
PF09252
(Feld-I_B) 		4 PRO A 110
GLY A 108
TYR A 113
VAL A 137
 None
 1.09A 5x80C-1puoA:
1.7
5x80D-1puoA:
1.6		 5x80C-1puoA:
26.14
5x80D-1puoA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 PRO A 434
GLY A 432
VAL A 412
ARG A 413
 None
FNS  A 570 (-3.4A)
None
FNS  A 570 (-3.3A)
 0.99A 5x80C-1qcwA:
0.0
5x80D-1qcwA:
0.0		 5x80C-1qcwA:
17.75
5x80D-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 PRO A 623
GLY A 624
TYR A 566
VAL A 569
 None
 1.31A 5x80C-1sy7A:
0.0
5x80D-1sy7A:
0.0		 5x80C-1sy7A:
11.80
5x80D-1sy7A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		4 PRO A   9
GLY A  86
VAL A  17
ARG A  21
 None
 1.44A 5x80C-1t1jA:
0.0
5x80D-1t1jA:
undetectable		 5x80C-1t1jA:
25.00
5x80D-1t1jA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		4 GLY A 158
TYR A 159
VAL A 154
ARG A 156
 None
 1.32A 5x80C-1t47A:
undetectable
5x80D-1t47A:
undetectable		 5x80C-1t47A:
20.42
5x80D-1t47A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLY A 197
TYR A 198
VAL A  52
ARG A 251
 None
 1.20A 5x80C-1v5vA:
undetectable
5x80D-1v5vA:
undetectable		 5x80C-1v5vA:
16.71
5x80D-1v5vA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbk HYPOTHETICAL PROTEIN
PH1313

(Pyrococcus
horikoshii) 		PF02568
(ThiI)
PF02926
(THUMP) 		4 PRO A 289
GLY A 262
TYR A 288
VAL A 259
 None
 1.19A 5x80C-1vbkA:
undetectable
5x80D-1vbkA:
undetectable		 5x80C-1vbkA:
19.03
5x80D-1vbkA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLY A 187
TYR A 188
VAL A  48
ARG A 227
 None
FFO  A2887 (-3.5A)
None
FFO  A2887 (-3.6A)
 1.22A 5x80C-1wopA:
undetectable
5x80D-1wopA:
undetectable		 5x80C-1wopA:
17.96
5x80D-1wopA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLY A 196
TYR A 197
VAL A  53
ARG A 233
 GLY  A 196 (-0.0A)
TYR  A 197 (-1.3A)
VAL  A  53 ( 0.6A)
ARG  A 233 (-0.6A)
 1.10A 5x80C-1wsvA:
undetectable
5x80D-1wsvA:
undetectable		 5x80C-1wsvA:
20.12
5x80D-1wsvA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 PRO A 599
GLY A 600
TYR A 602
VAL A 591
 None
MG  A7001 ( 4.8A)
None
None
 1.39A 5x80C-1yq2A:
undetectable
5x80D-1yq2A:
undetectable		 5x80C-1yq2A:
10.78
5x80D-1yq2A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkr MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 1, CHAIN 2

(Felis catus) 		PF01099
(Uteroglobin)
PF09252
(Feld-I_B) 		4 PRO A  18
GLY A  16
TYR A  21
VAL A  45
 None
 1.12A 5x80C-1zkrA:
3.1
5x80D-1zkrA:
2.8		 5x80C-1zkrA:
20.57
5x80D-1zkrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		4 PRO A 198
GLY A 171
TYR A 170
VAL A 223
 None
 1.30A 5x80C-1zq1A:
undetectable
5x80D-1zq1A:
undetectable		 5x80C-1zq1A:
16.67
5x80D-1zq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PRO A 389
GLY A 458
TYR A 270
VAL A 461
 None
 1.25A 5x80C-2aeyA:
undetectable
5x80D-2aeyA:
undetectable		 5x80C-2aeyA:
15.64
5x80D-2aeyA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 PRO A 473
GLY A 474
TYR A 501
VAL A 477
 None
 1.36A 5x80C-2b3xA:
undetectable
5x80D-2b3xA:
undetectable		 5x80C-2b3xA:
11.43
5x80D-2b3xA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 PRO A 106
GLY A 107
VAL A 203
ARG A 242
 None
 1.16A 5x80C-2d0oA:
2.6
5x80D-2d0oA:
1.8		 5x80C-2d0oA:
15.08
5x80D-2d0oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PRO A 147
GLY A 148
TYR A 146
VAL A 153
 None
 1.06A 5x80C-2d3tA:
1.2
5x80D-2d3tA:
1.5		 5x80C-2d3tA:
14.87
5x80D-2d3tA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5a HYPOTHETICAL PROTEIN
PH1109

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2) 		4 PRO A   6
GLY A   9
VAL A 128
ARG A 131
 None
 1.36A 5x80C-2d5aA:
undetectable
5x80D-2d5aA:
undetectable		 5x80C-2d5aA:
21.84
5x80D-2d5aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfk COLLYBISTIN II

(Rattus
norvegicus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PRO A 278
GLY A 280
TYR A 279
VAL A 333
 None
 1.23A 5x80C-2dfkA:
1.1
5x80D-2dfkA:
1.2		 5x80C-2dfkA:
17.81
5x80D-2dfkA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 PRO A 216
GLY A 127
TYR A 218
VAL A 282
 None
 0.94A 5x80C-2obeA:
undetectable
5x80D-2obeA:
undetectable		 5x80C-2obeA:
9.98
5x80D-2obeA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		4 PRO A  99
GLY A 100
TYR A 121
VAL A  69
 ADN  A   1 ( 4.9A)
None
None
None
 1.06A 5x80C-2q83A:
undetectable
5x80D-2q83A:
undetectable		 5x80C-2q83A:
20.90
5x80D-2q83A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PRO A 395
GLY A 466
TYR A 275
VAL A 469
 None
 1.23A 5x80C-2qquA:
undetectable
5x80D-2qquA:
undetectable		 5x80C-2qquA:
14.09
5x80D-2qquA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2spt PROTHROMBIN

(Bos taurus) 		PF00051
(Kringle)
PF00594
(Gla) 		4 PRO A 125
GLY A  71
TYR A  74
VAL A 143
 None
 1.40A 5x80C-2sptA:
undetectable
5x80D-2sptA:
undetectable		 5x80C-2sptA:
22.44
5x80D-2sptA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 PRO A 145
GLY A 143
TYR A 148
ARG A 518
 None
 0.88A 5x80C-2vgiA:
undetectable
5x80D-2vgiA:
undetectable		 5x80C-2vgiA:
16.63
5x80D-2vgiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A   6
TYR A   7
VAL A  17
ARG A  18
 None
 1.31A 5x80C-2wrtA:
undetectable
5x80D-2wrtA:
undetectable		 5x80C-2wrtA:
21.17
5x80D-2wrtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA

(Rhodococcus
erythropolis) 		PF02979
(NHase_alpha) 		4 PRO A  53
GLY A  56
VAL A 190
ARG A  54
 None
 1.34A 5x80C-2zpbA:
undetectable
5x80D-2zpbA:
undetectable		 5x80C-2zpbA:
21.53
5x80D-2zpbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 GLY A 114
TYR A 117
VAL A 206
ARG A 113
 None
 1.37A 5x80C-2zwvA:
undetectable
5x80D-2zwvA:
undetectable		 5x80C-2zwvA:
20.53
5x80D-2zwvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 PRO A 871
GLY A 996
VAL A 993
ARG A 977
 None
 1.44A 5x80C-2zxqA:
undetectable
5x80D-2zxqA:
undetectable		 5x80C-2zxqA:
9.57
5x80D-2zxqA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLY A 187
TYR A 188
VAL A  48
ARG A 223
 None
 1.05A 5x80C-3a8kA:
undetectable
5x80D-3a8kA:
undetectable		 5x80C-3a8kA:
19.89
5x80D-3a8kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 PRO A 202
GLY A 177
TYR A 178
VAL A 207
 None
 0.90A 5x80C-3al0A:
undetectable
5x80D-3al0A:
undetectable		 5x80C-3al0A:
16.45
5x80D-3al0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 PRO P 147
GLY P 144
TYR P 143
VAL P 171
 None
 1.36A 5x80C-3c5wP:
undetectable
5x80D-3c5wP:
undetectable		 5x80C-3c5wP:
20.20
5x80D-3c5wP:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE

(Methanoculleus
marisnigri) 		PF06314
(ADC) 		4 PRO A 200
GLY A 259
TYR A 199
VAL A 197
 None
None
P33  A 269 (-3.8A)
None
 1.35A 5x80C-3cmbA:
undetectable
5x80D-3cmbA:
undetectable		 5x80C-3cmbA:
23.05
5x80D-3cmbA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		4 PRO A 149
GLY A 171
TYR A 357
VAL A 174
 None
 1.38A 5x80C-3dzcA:
undetectable
5x80D-3dzcA:
undetectable		 5x80C-3dzcA:
20.60
5x80D-3dzcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		4 PRO A 226
GLY A 230
TYR A 225
VAL A 233
 None
 1.27A 5x80C-3enkA:
undetectable
5x80D-3enkA:
undetectable		 5x80C-3enkA:
20.17
5x80D-3enkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 PRO A 414
GLY A 417
TYR A 418
VAL A 409
 None
 1.28A 5x80C-3gtdA:
0.7
5x80D-3gtdA:
undetectable		 5x80C-3gtdA:
19.20
5x80D-3gtdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		4 PRO A 296
GLY A 297
TYR A 299
VAL A 256
 None
 1.34A 5x80C-3h2iA:
undetectable
5x80D-3h2iA:
undetectable		 5x80C-3h2iA:
17.18
5x80D-3h2iA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A  63
TYR A  65
VAL A  70
ARG A  73
 None
 1.38A 5x80C-3jq1A:
undetectable
5x80D-3jq1A:
undetectable		 5x80C-3jq1A:
15.64
5x80D-3jq1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PRO A  35
GLY A  36
TYR A  34
VAL A 424
 None
 1.18A 5x80C-3k92A:
undetectable
5x80D-3k92A:
undetectable		 5x80C-3k92A:
16.21
5x80D-3k92A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A  54
GLY A 402
TYR A 406
VAL A 408
 None
 1.09A 5x80C-3krtA:
undetectable
5x80D-3krtA:
undetectable		 5x80C-3krtA:
20.35
5x80D-3krtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 PRO A 468
GLY A 463
TYR A 467
VAL A 491
 None
 1.19A 5x80C-3kxwA:
undetectable
5x80D-3kxwA:
undetectable		 5x80C-3kxwA:
14.09
5x80D-3kxwA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PRO A 426
GLY A 428
TYR A 425
VAL A 394
 None
 1.30A 5x80C-3mogA:
undetectable
5x80D-3mogA:
undetectable		 5x80C-3mogA:
16.91
5x80D-3mogA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no4 CREATININE
AMIDOHYDROLASE

(Nostoc
punctiforme) 		PF02633
(Creatininase) 		4 PRO A 210
GLY A 212
TYR A 209
VAL A 193
 None
 0.73A 5x80C-3no4A:
undetectable
5x80D-3no4A:
undetectable		 5x80C-3no4A:
25.18
5x80D-3no4A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A 261
GLY A 263
TYR A 260
VAL A 319
 None
None
GAL  A1024 (-4.4A)
None
 1.00A 5x80C-3ogrA:
undetectable
5x80D-3ogrA:
undetectable		 5x80C-3ogrA:
10.37
5x80D-3ogrA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6

([Candida]
glabrata) 		PF14633
(SH2_2) 		4 PRO A1424
GLY A1415
TYR A1423
VAL A1426
 None
 1.34A 5x80C-3pjpA:
undetectable
5x80D-3pjpA:
undetectable		 5x80C-3pjpA:
20.60
5x80D-3pjpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		4 PRO A 327
GLY A 267
VAL A 258
ARG A 257
 None
 1.33A 5x80C-3pjxA:
1.7
5x80D-3pjxA:
undetectable		 5x80C-3pjxA:
17.70
5x80D-3pjxA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqc DNA-DIRECTED RNA
POLYMERASE SUBUNIT
B, DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A', DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Pyrococcus
furiosus) 		PF04560
(RNA_pol_Rpb2_7)
PF04997
(RNA_pol_Rpb1_1) 		4 PRO A 282
GLY A 136
VAL A 284
ARG A 287
 None
 1.28A 5x80C-3qqcA:
undetectable
5x80D-3qqcA:
undetectable		 5x80C-3qqcA:
16.75
5x80D-3qqcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		4 PRO A 303
GLY A 301
VAL A 281
ARG A 282
 FMN  A 401 (-4.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.9A)
 1.09A 5x80C-3sgzA:
undetectable
5x80D-3sgzA:
undetectable		 5x80C-3sgzA:
18.77
5x80D-3sgzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 PRO X 284
GLY X 285
TYR X 248
VAL X 280
 PLP  X 502 (-4.2A)
None
None
PLP  X 502 (-3.8A)
 1.33A 5x80C-3ss7X:
undetectable
5x80D-3ss7X:
undetectable		 5x80C-3ss7X:
17.23
5x80D-3ss7X:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PRO A  65
GLY A  54
TYR A  53
VAL A  62
 None
 1.44A 5x80C-3t9wA:
undetectable
5x80D-3t9wA:
undetectable		 5x80C-3t9wA:
25.98
5x80D-3t9wA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A 611
GLY A 563
TYR A 565
VAL A 526
 None
 1.25A 5x80C-3uk1A:
undetectable
5x80D-3uk1A:
undetectable		 5x80C-3uk1A:
13.64
5x80D-3uk1A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Streptomyces
avermitilis) 		PF00215
(OMPdecase) 		4 PRO A 129
GLY A 132
TYR A 130
VAL A 175
 None
 1.09A 5x80C-3v75A:
undetectable
5x80D-3v75A:
undetectable		 5x80C-3v75A:
25.83
5x80D-3v75A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 STROMELYSIN-2

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 PRO B 145
GLY B 263
TYR B 262
VAL B 143
 None
 1.43A 5x80C-3v96B:
undetectable
5x80D-3v96B:
undetectable		 5x80C-3v96B:
19.65
5x80D-3v96B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w95 GENOME POLYPROTEIN

(Enterovirus A) 		PF00947
(Pico_P2A) 		4 PRO A  91
TYR A  90
VAL A  84
ARG A  93
 None
 1.23A 5x80C-3w95A:
undetectable
5x80D-3w95A:
undetectable		 5x80C-3w95A:
27.42
5x80D-3w95A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 PRO B 529
GLY B 527
TYR B 547
VAL B 487
 None
 1.29A 5x80C-3x17B:
undetectable
5x80D-3x17B:
undetectable		 5x80C-3x17B:
16.25
5x80D-3x17B:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		4 PRO A 223
GLY A 300
TYR A 301
VAL A 305
 None
 1.38A 5x80C-4avoA:
undetectable
5x80D-4avoA:
undetectable		 5x80C-4avoA:
15.83
5x80D-4avoA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 PRO A 134
GLY A 104
TYR A 142
VAL A 144
 GSP  A1342 ( 4.4A)
GSP  A1342 ( 4.6A)
None
None
 1.24A 5x80C-4b45A:
undetectable
5x80D-4b45A:
undetectable		 5x80C-4b45A:
22.51
5x80D-4b45A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A  34
TYR A 252
VAL A  10
ARG A  14
 None
 1.11A 5x80C-4c7vA:
undetectable
5x80D-4c7vA:
undetectable		 5x80C-4c7vA:
13.80
5x80D-4c7vA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cya DPSA15

(Streptomyces
coelicolor) 		PF00210
(Ferritin) 		4 PRO A   7
GLY A  81
TYR A   9
VAL A  11
 None
 1.44A 5x80C-4cyaA:
1.8
5x80D-4cyaA:
undetectable		 5x80C-4cyaA:
25.52
5x80D-4cyaA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1t INVASIN

(Yersinia
pseudotuberculosis) 		PF11924
(IAT_beta) 		4 GLY A 270
TYR A 248
VAL A 386
ARG A 229
 None
 0.91A 5x80C-4e1tA:
undetectable
5x80D-4e1tA:
undetectable		 5x80C-4e1tA:
19.03
5x80D-4e1tA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 PRO A 123
GLY A  56
TYR A  57
VAL A  64
 None
 1.30A 5x80C-4hqnA:
undetectable
5x80D-4hqnA:
undetectable		 5x80C-4hqnA:
17.83
5x80D-4hqnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 PRO B 612
GLY B 614
TYR B 611
ARG B 411
 None
 1.06A 5x80C-4iglB:
undetectable
5x80D-4iglB:
undetectable		 5x80C-4iglB:
14.24
5x80D-4iglB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A 261
GLY A 263
TYR A 260
VAL A 319
 None
None
GAL  A1130 (-4.5A)
None
 0.97A 5x80C-4iugA:
undetectable
5x80D-4iugA:
undetectable		 5x80C-4iugA:
10.46
5x80D-4iugA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg3 PROTEASE 2A

(Enterovirus A) 		PF00947
(Pico_P2A) 		4 PRO A  91
TYR A  90
VAL A  84
ARG A  93
 None
None
TRS  A 203 (-3.9A)
None
 1.35A 5x80C-4mg3A:
undetectable
5x80D-4mg3A:
undetectable		 5x80C-4mg3A:
22.86
5x80D-4mg3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 PRO A 425
GLY A 427
TYR A 424
VAL A 456
 None
 1.17A 5x80C-4n2cA:
undetectable
5x80D-4n2cA:
undetectable		 5x80C-4n2cA:
13.50
5x80D-4n2cA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		4 PRO A 476
GLY A 453
TYR A 454
VAL A 456
 None
 1.31A 5x80C-4n75A:
undetectable
5x80D-4n75A:
undetectable		 5x80C-4n75A:
18.67
5x80D-4n75A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o96 TYPE III EFFECTOR
PROTEIN KINASE

(Escherichia
coli) 		no annotation 4 PRO A 145
GLY A 146
TYR A 158
VAL A 167
 None
None
None
GOL  A 401 (-4.7A)
 1.44A 5x80C-4o96A:
undetectable
5x80D-4o96A:
undetectable		 5x80C-4o96A:
21.11
5x80D-4o96A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 PRO A2113
GLY A2115
TYR A2112
ARG A1911
 None
 1.06A 5x80C-4o9xA:
undetectable
5x80D-4o9xA:
undetectable		 5x80C-4o9xA:
6.19
5x80D-4o9xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozu CORONIN

(Toxoplasma
gondii) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		4 PRO A  68
GLY A  65
TYR A  22
VAL A 341
 None
 1.08A 5x80C-4ozuA:
undetectable
5x80D-4ozuA:
undetectable		 5x80C-4ozuA:
17.01
5x80D-4ozuA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3y THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Acinetobacter
baumannii) 		PF01323
(DSBA) 		4 GLY B 116
TYR B 115
VAL B  83
ARG B  86
 None
 1.37A 5x80C-4p3yB:
undetectable
5x80D-4p3yB:
undetectable		 5x80C-4p3yB:
19.69
5x80D-4p3yB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		4 GLY A 216
TYR A 312
VAL A 320
ARG A 325
 None
 1.41A 5x80C-4qx8A:
undetectable
5x80D-4qx8A:
undetectable		 5x80C-4qx8A:
18.51
5x80D-4qx8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		4 PRO A 427
GLY A 423
TYR A 424
VAL A 491
 None
 1.37A 5x80C-4wrmA:
undetectable
5x80D-4wrmA:
undetectable		 5x80C-4wrmA:
17.89
5x80D-4wrmA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Jonesia
denitrificans) 		PF00697
(PRAI) 		4 GLY A 118
TYR A 117
VAL A 114
ARG A 102
 None
 1.32A 5x80C-4wuiA:
undetectable
5x80D-4wuiA:
undetectable		 5x80C-4wuiA:
26.20
5x80D-4wuiA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 PRO A  74
GLY A 255
TYR A 229
ARG A  96
 None
None
ICS  A1496 (-4.1A)
ICS  A1496 (-4.0A)
 1.12A 5x80C-4wzbA:
undetectable
5x80D-4wzbA:
undetectable		 5x80C-4wzbA:
17.04
5x80D-4wzbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLY A 274
TYR A 276
VAL A 293
ARG A 278
 None
 1.20A 5x80C-5c92A:
undetectable
5x80D-5c92A:
undetectable		 5x80C-5c92A:
15.37
5x80D-5c92A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		4 PRO A 431
GLY A 434
TYR A 432
VAL A 534
 None
 1.07A 5x80C-5do7A:
0.1
5x80D-5do7A:
undetectable		 5x80C-5do7A:
13.24
5x80D-5do7A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE

(Legionella
pneumophila) 		PF00156
(Pribosyltran) 		4 PRO A  55
GLY A 165
TYR A 164
VAL A 135
 None
 1.15A 5x80C-5esxA:
undetectable
5x80D-5esxA:
0.9		 5x80C-5esxA:
22.44
5x80D-5esxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 616
GLY A 642
TYR A 641
VAL A 672
 None
 1.41A 5x80C-5fr8A:
undetectable
5x80D-5fr8A:
undetectable		 5x80C-5fr8A:
11.48
5x80D-5fr8A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		4 PRO A   4
GLY A   5
VAL A   9
ARG A  25
 None
 1.11A 5x80C-5g4xA:
undetectable
5x80D-5g4xA:
undetectable		 5x80C-5g4xA:
20.18
5x80D-5g4xA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 PRO A 426
GLY A 428
TYR A 425
VAL A 457
 None
 1.16A 5x80C-5hp5A:
undetectable
5x80D-5hp5A:
undetectable		 5x80C-5hp5A:
15.77
5x80D-5hp5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2b PEPTIDE DEFORMYLASE

(Burkholderia
ambifaria) 		PF01327
(Pep_deformylase) 		4 PRO A  83
GLY A 119
TYR A 117
VAL A  79
 None
None
None
EDO  A 207 ( 4.3A)
 1.43A 5x80C-5i2bA:
undetectable
5x80D-5i2bA:
undetectable		 5x80C-5i2bA:
24.75
5x80D-5i2bA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		4 PRO A 366
GLY A 325
TYR A 269
VAL A 330
 None
 1.06A 5x80C-5j78A:
undetectable
5x80D-5j78A:
0.8		 5x80C-5j78A:
17.42
5x80D-5j78A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 PRO A 719
GLY A 652
VAL A 626
ARG A 721
 None
 1.04A 5x80C-5jrlA:
undetectable
5x80D-5jrlA:
undetectable		 5x80C-5jrlA:
15.14
5x80D-5jrlA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3z POLYKETIDE
KETOREDUCTASE SIMC7

(Streptomyces
antibioticus) 		PF13460
(NAD_binding_10) 		4 PRO A 156
GLY A 157
TYR A 155
ARG A 215
 None
 0.91A 5x80C-5l3zA:
undetectable
5x80D-5l3zA:
undetectable		 5x80C-5l3zA:
26.71
5x80D-5l3zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lz6 GOLGI RESIDENT
PROTEIN GCP60

(Homo sapiens) 		PF13897
(GOLD_2) 		4 PRO A 499
GLY A 500
TYR A 498
VAL A 503
 None
 1.24A 5x80C-5lz6A:
undetectable
5x80D-5lz6A:
undetectable		 5x80C-5lz6A:
19.44
5x80D-5lz6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 PRO A 174
GLY A 181
TYR A 221
VAL A 243
 None
 1.19A 5x80C-5neuA:
undetectable
5x80D-5neuA:
undetectable		 5x80C-5neuA:
14.82
5x80D-5neuA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 PRO A 458
GLY A 466
VAL A 391
ARG A 390
 None
 1.13A 5x80C-5u8zA:
undetectable
5x80D-5u8zA:
undetectable		 5x80C-5u8zA:
16.54
5x80D-5u8zA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 GLY A 341
TYR A 340
VAL A 345
ARG A 313
 None
 1.39A 5x80C-5vi6A:
undetectable
5x80D-5vi6A:
undetectable		 5x80C-5vi6A:
18.38
5x80D-5vi6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		4 PRO A 170
GLY A 168
VAL A 120
ARG A 173
 None
 1.43A 5x80C-5visA:
undetectable
5x80D-5visA:
undetectable		 5x80C-5visA:
19.84
5x80D-5visA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 4 PRO A 180
GLY A 178
TYR A 183
VAL A  94
 None
 1.30A 5x80C-6b7pA:
undetectable
5x80D-6b7pA:
undetectable		 5x80C-6b7pA:
20.42
5x80D-6b7pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 PRO A 400
GLY A 424
TYR A 399
VAL A 421
 None
 1.22A 5x80C-6chjA:
undetectable
5x80D-6chjA:
undetectable		 5x80C-6chjA:
18.35
5x80D-6chjA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 GLY A 242
TYR A 243
VAL A 524
ARG A 523
 None
 1.37A 5x80C-6es9A:
0.9
5x80D-6es9A:
0.9		 5x80C-6es9A:
23.90
5x80D-6es9A:
23.90