SIMILAR PATTERNS OF AMINO ACIDS FOR 5X80_A_SALA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea)
PF01070
(FMN_dh)
4 VAL A 288
ARG A 289
PRO A 310
GLY A 308
None
FMN  A 360 (-2.9A)
None
FMN  A 360 (-3.5A)
0.94A 5x80A-1al8A:
0.0
5x80B-1al8A:
0.0
5x80A-1al8A:
22.28
5x80B-1al8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR


(Rattus
norvegicus)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL B  34
PRO B 100
GLY B 100
TYR B 100
None
1.03A 5x80A-1fn4B:
undetectable
5x80B-1fn4B:
undetectable
5x80A-1fn4B:
19.82
5x80B-1fn4B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1


(Homo sapiens)
PF00415
(RCC1)
4 VAL B  80
PRO B 112
GLY B 113
TYR B  89
None
1.30A 5x80A-1i2mB:
undetectable
5x80B-1i2mB:
undetectable
5x80A-1i2mB:
19.10
5x80B-1i2mB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm7 BRCA1-ASSOCIATED
RING DOMAIN PROTEIN
1


(Homo sapiens)
PF14835
(zf-RING_6)
4 VAL B  75
ARG B  52
PRO B  84
GLY B  82
None
1.14A 5x80A-1jm7B:
undetectable
5x80B-1jm7B:
undetectable
5x80A-1jm7B:
21.12
5x80B-1jm7B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum)
PF00293
(NUDIX)
4 VAL A  14
PRO A  28
GLY A   6
TYR A  27
None
1.22A 5x80A-1k26A:
undetectable
5x80B-1k26A:
undetectable
5x80A-1k26A:
22.73
5x80B-1k26A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae)
PF00173
(Cyt-b5)
PF01070
(FMN_dh)
4 VAL A 412
ARG A 413
PRO A 434
GLY A 432
None
FMN  A 570 (-3.9A)
None
FMN  A 570 (-3.8A)
0.94A 5x80A-1ltdA:
0.4
5x80B-1ltdA:
0.0
5x80A-1ltdA:
16.85
5x80B-1ltdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi)
PF13385
(Laminin_G_3)
PF13859
(BNR_3)
4 VAL A 181
PRO A 193
GLY A 178
TYR A 192
None
1.34A 5x80A-1ms8A:
undetectable
5x80B-1ms8A:
undetectable
5x80A-1ms8A:
14.04
5x80B-1ms8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od5 GLYCININ

(Glycine max)
PF00190
(Cupin_1)
4 VAL A 204
PRO A 169
GLY A 167
TYR A 164
None
1.19A 5x80A-1od5A:
0.0
5x80B-1od5A:
0.0
5x80A-1od5A:
13.62
5x80B-1od5A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puo MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 2, CHAIN 1


(Felis catus)
PF01099
(Uteroglobin)
PF09252
(Feld-I_B)
4 VAL A 137
PRO A 110
GLY A 108
TYR A 113
None
1.18A 5x80A-1puoA:
2.3
5x80B-1puoA:
1.7
5x80A-1puoA:
26.14
5x80B-1puoA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae)
PF01070
(FMN_dh)
4 VAL A 412
ARG A 413
PRO A 434
GLY A 432
None
FNS  A 570 (-3.3A)
None
FNS  A 570 (-3.4A)
0.95A 5x80A-1qcwA:
0.0
5x80B-1qcwA:
0.2
5x80A-1qcwA:
17.75
5x80B-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp0 CYTOCHROME C OXIDASE
ASSEMBLY PROTEIN
CTAG


(Sinorhizobium
meliloti)
PF04442
(CtaG_Cox11)
4 VAL A  41
PRO A 146
GLY A  44
TYR A 145
None
1.35A 5x80A-1sp0A:
undetectable
5x80B-1sp0A:
undetectable
5x80A-1sp0A:
21.91
5x80B-1sp0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa)
PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel)
4 VAL A 569
PRO A 623
GLY A 624
TYR A 566
None
1.32A 5x80A-1sy7A:
0.0
5x80B-1sy7A:
0.0
5x80A-1sy7A:
11.80
5x80B-1sy7A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t07 HYPOTHETICAL UPF0269
PROTEIN PA5148


(Pseudomonas
aeruginosa)
PF04362
(Iron_traffic)
4 VAL A  34
PRO A  21
GLY A  27
TYR A  31
None
1.33A 5x80A-1t07A:
0.4
5x80B-1t07A:
0.5
5x80A-1t07A:
19.88
5x80B-1t07A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF09152
(DUF1937)
4 VAL A  17
ARG A  21
PRO A   9
GLY A  86
None
1.45A 5x80A-1t1jA:
0.0
5x80B-1t1jA:
0.0
5x80A-1t1jA:
25.00
5x80B-1t1jA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE


(Pyrococcus
horikoshii)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 VAL A  52
ARG A 251
GLY A 197
TYR A 198
None
1.11A 5x80A-1v5vA:
0.0
5x80B-1v5vA:
0.0
5x80A-1v5vA:
16.71
5x80B-1v5vA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE


(Thermotoga
maritima)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 VAL A  48
ARG A 227
GLY A 187
TYR A 188
None
FFO  A2887 (-3.6A)
None
FFO  A2887 (-3.5A)
1.13A 5x80A-1wopA:
undetectable
5x80B-1wopA:
undetectable
5x80A-1wopA:
17.96
5x80B-1wopA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE


(Homo sapiens)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 VAL A  53
ARG A 233
GLY A 196
TYR A 197
VAL  A  53 ( 0.6A)
ARG  A 233 (-0.6A)
GLY  A 196 (-0.0A)
TYR  A 197 (-1.3A)
1.03A 5x80A-1wsvA:
undetectable
5x80B-1wsvA:
undetectable
5x80A-1wsvA:
20.12
5x80B-1wsvA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D


(Pyrococcus
abyssi)
PF00710
(Asparaginase)
4 VAL A 223
PRO A 198
GLY A 171
TYR A 170
None
1.36A 5x80A-1zq1A:
undetectable
5x80B-1zq1A:
undetectable
5x80A-1zq1A:
16.67
5x80B-1zq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA


(Cichorium
intybus)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 VAL A 461
PRO A 389
GLY A 458
TYR A 270
None
1.35A 5x80A-2aeyA:
undetectable
5x80B-2aeyA:
undetectable
5x80A-2aeyA:
15.64
5x80B-2aeyA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1


(Homo sapiens)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
4 VAL A 477
PRO A 473
GLY A 474
TYR A 501
None
1.32A 5x80A-2b3xA:
undetectable
5x80B-2b3xA:
undetectable
5x80A-2b3xA:
11.43
5x80B-2b3xA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT


(Klebsiella
oxytoca)
PF08841
(DDR)
4 VAL A 203
ARG A 242
PRO A 106
GLY A 107
None
1.17A 5x80A-2d0oA:
2.2
5x80B-2d0oA:
undetectable
5x80A-2d0oA:
15.08
5x80B-2d0oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT


(Pseudomonas
fragi)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 VAL A 153
PRO A 147
GLY A 148
TYR A 146
None
1.08A 5x80A-2d3tA:
undetectable
5x80B-2d3tA:
1.3
5x80A-2d3tA:
14.87
5x80B-2d3tA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5a HYPOTHETICAL PROTEIN
PH1109


(Pyrococcus
horikoshii)
PF13380
(CoA_binding_2)
4 VAL A 128
ARG A 131
PRO A   6
GLY A   9
None
1.37A 5x80A-2d5aA:
undetectable
5x80B-2d5aA:
undetectable
5x80A-2d5aA:
21.84
5x80B-2d5aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans)
PF02621
(VitK2_biosynth)
4 VAL A 132
ARG A 106
GLY A 150
TYR A 148
None
1.43A 5x80A-2i6eA:
undetectable
5x80B-2i6eA:
undetectable
5x80A-2i6eA:
23.33
5x80B-2i6eA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans)
PF01070
(FMN_dh)
4 VAL A 299
ARG A 300
PRO A 321
GLY A 319
None
FMN  A1375 (-2.9A)
None
FMN  A1375 (-3.3A)
1.03A 5x80A-2nliA:
undetectable
5x80B-2nliA:
undetectable
5x80A-2nliA:
19.55
5x80B-2nliA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis)
PF01636
(APH)
4 VAL A  69
PRO A  99
GLY A 100
TYR A 121
None
ADN  A   1 ( 4.9A)
None
None
1.12A 5x80A-2q83A:
undetectable
5x80B-2q83A:
undetectable
5x80A-2q83A:
20.90
5x80B-2q83A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE


(Arabidopsis
thaliana)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 VAL A 469
PRO A 395
GLY A 466
TYR A 275
None
1.30A 5x80A-2qquA:
undetectable
5x80B-2qquA:
undetectable
5x80A-2qquA:
14.09
5x80B-2qquA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2spt PROTHROMBIN

(Bos taurus)
PF00051
(Kringle)
PF00594
(Gla)
4 VAL A 143
PRO A 125
GLY A  71
TYR A  74
None
1.36A 5x80A-2sptA:
undetectable
5x80B-2sptA:
undetectable
5x80A-2sptA:
22.44
5x80B-2sptA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L


(Homo sapiens)
PF00224
(PK)
PF02887
(PK_C)
4 ARG A 518
PRO A 145
GLY A 143
TYR A 148
None
0.91A 5x80A-2vgiA:
undetectable
5x80B-2vgiA:
undetectable
5x80A-2vgiA:
16.63
5x80B-2vgiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51


(Fasciola
hepatica)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 VAL A  17
ARG A  18
GLY A   6
TYR A   7
None
1.42A 5x80A-2wrtA:
undetectable
5x80B-2wrtA:
undetectable
5x80A-2wrtA:
21.17
5x80B-2wrtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE


(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 VAL A 184
PRO A 142
GLY A 194
TYR A 141
None
1.28A 5x80A-2ybuA:
undetectable
5x80B-2ybuA:
undetectable
5x80A-2ybuA:
16.80
5x80B-2ybuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Bifidobacterium
longum)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 VAL A 993
ARG A 977
PRO A 871
GLY A 996
None
1.44A 5x80A-2zxqA:
undetectable
5x80B-2zxqA:
undetectable
5x80A-2zxqA:
9.57
5x80B-2zxqA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE


(Escherichia
coli)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 VAL A  48
ARG A 223
GLY A 187
TYR A 188
None
0.96A 5x80A-3a8kA:
undetectable
5x80B-3a8kA:
undetectable
5x80A-3a8kA:
19.89
5x80B-3a8kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Thermotoga
maritima)
PF01425
(Amidase)
4 VAL A 207
PRO A 202
GLY A 177
TYR A 178
None
0.94A 5x80A-3al0A:
undetectable
5x80B-3al0A:
undetectable
5x80A-3al0A:
16.45
5x80B-3al0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apm PROTEIN-ARGININE
DEIMINASE TYPE-4


(Homo sapiens)
PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M)
4 VAL A 456
PRO A 424
GLY A 426
TYR A 423
None
1.23A 5x80A-3apmA:
undetectable
5x80B-3apmA:
undetectable
5x80A-3apmA:
14.02
5x80B-3apmA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE


(Methanoculleus
marisnigri)
PF06314
(ADC)
4 VAL A 197
PRO A 200
GLY A 259
TYR A 199
None
None
None
P33  A 269 (-3.8A)
1.34A 5x80A-3cmbA:
undetectable
5x80B-3cmbA:
undetectable
5x80A-3cmbA:
23.05
5x80B-3cmbA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Vibrio cholerae)
PF02350
(Epimerase_2)
4 VAL A 174
PRO A 149
GLY A 171
TYR A 357
None
1.43A 5x80A-3dzcA:
undetectable
5x80B-3dzcA:
undetectable
5x80A-3dzcA:
20.60
5x80B-3dzcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis)
PF00190
(Cupin_1)
4 VAL A 271
PRO A 228
GLY A 226
TYR A 223
None
1.36A 5x80A-3ehkA:
undetectable
5x80B-3ehkA:
undetectable
5x80A-3ehkA:
13.45
5x80B-3ehkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II


(Rickettsia
prowazekii)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 VAL A 409
PRO A 414
GLY A 417
TYR A 418
None
1.29A 5x80A-3gtdA:
undetectable
5x80B-3gtdA:
undetectable
5x80A-3gtdA:
19.20
5x80B-3gtdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides)
PF00202
(Aminotran_3)
4 VAL A 204
PRO A 237
GLY A 239
TYR A 240
None
1.23A 5x80A-3i5tA:
2.4
5x80B-3i5tA:
2.7
5x80A-3i5tA:
15.51
5x80B-3i5tA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN


(Homo sapiens)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2)
4 VAL B1933
PRO B2024
GLY B2026
TYR B2017
None
1.40A 5x80A-3j2sB:
undetectable
5x80B-3j2sB:
undetectable
5x80A-3j2sB:
13.71
5x80B-3j2sB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN


(Bacteroides
vulgatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
4 VAL A  70
ARG A  73
GLY A  63
TYR A  65
None
1.35A 5x80A-3jq1A:
undetectable
5x80B-3jq1A:
undetectable
5x80A-3jq1A:
15.64
5x80B-3jq1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 VAL A 424
PRO A  35
GLY A  36
TYR A  34
None
1.14A 5x80A-3k92A:
undetectable
5x80B-3k92A:
undetectable
5x80A-3k92A:
16.21
5x80B-3k92A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE


(Streptomyces
coelicolor)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 VAL A 408
PRO A  54
GLY A 402
TYR A 406
None
1.08A 5x80A-3krtA:
undetectable
5x80B-3krtA:
undetectable
5x80A-3krtA:
20.35
5x80B-3krtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B


(Legionella
pneumophila)
PF00501
(AMP-binding)
4 VAL A 491
PRO A 468
GLY A 463
TYR A 467
None
1.16A 5x80A-3kxwA:
undetectable
5x80B-3kxwA:
undetectable
5x80A-3kxwA:
14.09
5x80B-3kxwA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans)
PF00501
(AMP-binding)
4 VAL A 296
ARG A 335
GLY A 308
TYR A 307
None
1.42A 5x80A-3l2kA:
undetectable
5x80B-3l2kA:
undetectable
5x80A-3l2kA:
18.03
5x80B-3l2kA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE


(Escherichia
coli)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 VAL A 394
PRO A 426
GLY A 428
TYR A 425
None
1.30A 5x80A-3mogA:
undetectable
5x80B-3mogA:
undetectable
5x80A-3mogA:
16.91
5x80B-3mogA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no4 CREATININE
AMIDOHYDROLASE


(Nostoc
punctiforme)
PF02633
(Creatininase)
4 VAL A 193
PRO A 210
GLY A 212
TYR A 209
None
0.80A 5x80A-3no4A:
undetectable
5x80B-3no4A:
undetectable
5x80A-3no4A:
25.18
5x80B-3no4A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN


(Escherichia
coli)
PF00496
(SBP_bac_5)
4 VAL A 386
PRO A 356
GLY A 352
TYR A 351
None
1.12A 5x80A-3o9pA:
undetectable
5x80B-3o9pA:
undetectable
5x80A-3o9pA:
16.11
5x80B-3o9pA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6


([Candida]
glabrata)
PF14633
(SH2_2)
4 VAL A1426
PRO A1424
GLY A1415
TYR A1423
None
1.34A 5x80A-3pjpA:
undetectable
5x80B-3pjpA:
undetectable
5x80A-3pjpA:
20.60
5x80B-3pjpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
4 VAL A 281
ARG A 282
PRO A 303
GLY A 301
None
FMN  A 401 (-2.9A)
FMN  A 401 (-4.8A)
FMN  A 401 (-3.4A)
1.05A 5x80A-3sgzA:
0.1
5x80B-3sgzA:
0.2
5x80A-3sgzA:
18.77
5x80B-3sgzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1


(Actinomyces
oris)
no annotation 4 VAL A 215
PRO A 218
GLY A 219
TYR A 217
None
1.29A 5x80A-3uxfA:
undetectable
5x80B-3uxfA:
undetectable
5x80A-3uxfA:
16.97
5x80B-3uxfA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1


(Actinomyces
oris)
no annotation 4 VAL A 215
PRO A 218
GLY A 220
TYR A 217
None
1.12A 5x80A-3uxfA:
undetectable
5x80B-3uxfA:
undetectable
5x80A-3uxfA:
16.97
5x80B-3uxfA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Streptomyces
avermitilis)
PF00215
(OMPdecase)
4 VAL A 175
PRO A 129
GLY A 132
TYR A 130
None
1.13A 5x80A-3v75A:
undetectable
5x80B-3v75A:
undetectable
5x80A-3v75A:
25.83
5x80B-3v75A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 STROMELYSIN-2

(Homo sapiens)
PF00413
(Peptidase_M10)
4 VAL B 143
PRO B 145
GLY B 263
TYR B 262
None
1.44A 5x80A-3v96B:
undetectable
5x80B-3v96B:
undetectable
5x80A-3v96B:
19.65
5x80B-3v96B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 VAL A 252
PRO A 183
GLY A 190
TYR A 230
None
1.42A 5x80A-3vi3A:
undetectable
5x80B-3vi3A:
undetectable
5x80A-3vi3A:
14.17
5x80B-3vi3A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w95 GENOME POLYPROTEIN

(Enterovirus A)
PF00947
(Pico_P2A)
4 VAL A  84
ARG A  93
PRO A  91
TYR A  90
None
1.21A 5x80A-3w95A:
undetectable
5x80B-3w95A:
undetectable
5x80A-3w95A:
27.42
5x80B-3w95A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium)
no annotation 4 VAL B 487
PRO B 529
GLY B 527
TYR B 547
None
1.30A 5x80A-3x17B:
undetectable
5x80B-3x17B:
undetectable
5x80A-3x17B:
16.25
5x80B-3x17B:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E


(Thermobifida
fusca)
PF01341
(Glyco_hydro_6)
4 VAL A 305
PRO A 223
GLY A 300
TYR A 301
None
1.39A 5x80A-4avoA:
undetectable
5x80B-4avoA:
undetectable
5x80A-4avoA:
15.83
5x80B-4avoA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF00043
(GST_C)
4 VAL A 189
PRO A 154
GLY A 150
TYR A 153
None
1.15A 5x80A-4bvxA:
undetectable
5x80B-4bvxA:
undetectable
5x80A-4bvxA:
23.21
5x80B-4bvxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 VAL A  10
ARG A  14
GLY A  34
TYR A 252
None
1.11A 5x80A-4c7vA:
undetectable
5x80B-4c7vA:
undetectable
5x80A-4c7vA:
13.80
5x80B-4c7vA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 VAL A 152
PRO A  83
GLY A  58
TYR A  81
None
1.44A 5x80A-4d4gA:
undetectable
5x80B-4d4gA:
undetectable
5x80A-4d4gA:
15.36
5x80B-4d4gA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1t INVASIN

(Yersinia
pseudotuberculosis)
PF11924
(IAT_beta)
4 VAL A 386
ARG A 229
GLY A 270
TYR A 248
None
0.95A 5x80A-4e1tA:
undetectable
5x80B-4e1tA:
undetectable
5x80A-4e1tA:
19.03
5x80B-4e1tA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2


(Plasmodium
vivax)
PF00090
(TSP_1)
PF00092
(VWA)
4 VAL A  64
PRO A 123
GLY A  56
TYR A  57
None
1.25A 5x80A-4hqnA:
undetectable
5x80B-4hqnA:
undetectable
5x80A-4hqnA:
17.83
5x80B-4hqnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga)
no annotation 4 ARG B 411
PRO B 612
GLY B 614
TYR B 611
None
1.03A 5x80A-4iglB:
undetectable
5x80B-4iglB:
undetectable
5x80A-4iglB:
14.24
5x80B-4iglB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 VAL A 319
PRO A 261
GLY A 263
TYR A 260
None
None
None
GAL  A1130 (-4.5A)
1.00A 5x80A-4iugA:
undetectable
5x80B-4iugA:
undetectable
5x80A-4iugA:
10.46
5x80B-4iugA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg3 PROTEASE 2A

(Enterovirus A)
PF00947
(Pico_P2A)
4 VAL A  84
ARG A  93
PRO A  91
TYR A  90
TRS  A 203 (-3.9A)
None
None
None
1.35A 5x80A-4mg3A:
undetectable
5x80B-4mg3A:
undetectable
5x80A-4mg3A:
22.86
5x80B-4mg3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF12741
(SusD-like)
4 VAL A 421
PRO A 401
GLY A 293
TYR A 290
None
1.43A 5x80A-4mruA:
undetectable
5x80B-4mruA:
undetectable
5x80A-4mruA:
14.75
5x80B-4mruA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2


(Homo sapiens)
PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M)
4 VAL A 456
PRO A 425
GLY A 427
TYR A 424
None
1.20A 5x80A-4n2cA:
undetectable
5x80B-4n2cA:
undetectable
5x80A-4n2cA:
13.50
5x80B-4n2cA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


(Escherichia
coli)
PF01103
(Bac_surface_Ag)
4 VAL A 456
PRO A 476
GLY A 453
TYR A 454
None
1.37A 5x80A-4n75A:
undetectable
5x80B-4n75A:
undetectable
5x80A-4n75A:
18.67
5x80B-4n75A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o96 TYPE III EFFECTOR
PROTEIN KINASE


(Escherichia
coli)
no annotation 4 VAL A 167
PRO A 145
GLY A 146
TYR A 158
GOL  A 401 (-4.7A)
None
None
None
1.43A 5x80A-4o96A:
undetectable
5x80B-4o96A:
undetectable
5x80A-4o96A:
21.11
5x80B-4o96A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
4 ARG A1911
PRO A2113
GLY A2115
TYR A2112
None
1.05A 5x80A-4o9xA:
undetectable
5x80B-4o9xA:
undetectable
5x80A-4o9xA:
6.19
5x80B-4o9xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozu CORONIN

(Toxoplasma
gondii)
PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4)
4 VAL A 341
PRO A  68
GLY A  65
TYR A  22
None
1.18A 5x80A-4ozuA:
undetectable
5x80B-4ozuA:
undetectable
5x80A-4ozuA:
17.01
5x80B-4ozuA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3y THIOL:DISULFIDE
INTERCHANGE PROTEIN


(Acinetobacter
baumannii)
PF01323
(DSBA)
4 VAL B  83
ARG B  86
GLY B 116
TYR B 115
None
1.39A 5x80A-4p3yB:
undetectable
5x80B-4p3yB:
undetectable
5x80A-4p3yB:
19.69
5x80B-4p3yB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A


(Mus musculus)
PF02373
(JmjC)
4 VAL A 320
ARG A 325
GLY A 216
TYR A 312
None
1.35A 5x80A-4qx8A:
undetectable
5x80B-4qx8A:
undetectable
5x80A-4qx8A:
18.51
5x80B-4qx8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 VAL A 243
PRO A 174
GLY A 181
TYR A 221
None
1.21A 5x80A-4um8A:
undetectable
5x80B-4um8A:
undetectable
5x80A-4um8A:
12.04
5x80B-4um8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens)
PF01839
(FG-GAP)
4 VAL A 252
PRO A 183
GLY A 190
TYR A 230
None
1.35A 5x80A-4wk4A:
undetectable
5x80B-4wk4A:
undetectable
5x80A-4wk4A:
17.38
5x80B-4wk4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
4 VAL A 487
ARG A 489
GLY A 636
TYR A 627
None
1.26A 5x80A-4woeA:
undetectable
5x80B-4woeA:
undetectable
5x80A-4woeA:
12.67
5x80B-4woeA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE


(Jonesia
denitrificans)
PF00697
(PRAI)
4 VAL A 114
ARG A 102
GLY A 118
TYR A 117
None
1.34A 5x80A-4wuiA:
undetectable
5x80B-4wuiA:
undetectable
5x80A-4wuiA:
26.20
5x80B-4wuiA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
4 ARG A  96
PRO A  74
GLY A 255
TYR A 229
ICS  A1496 (-4.0A)
None
None
ICS  A1496 (-4.1A)
1.14A 5x80A-4wzbA:
undetectable
5x80B-4wzbA:
undetectable
5x80A-4wzbA:
17.04
5x80B-4wzbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN


(Colletotrichum
graminicola)
PF01344
(Kelch_1)
PF09118
(DUF1929)
4 VAL A 293
ARG A 278
GLY A 274
TYR A 276
None
1.18A 5x80A-5c92A:
undetectable
5x80B-5c92A:
undetectable
5x80A-5c92A:
15.37
5x80B-5c92A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6


(Homo sapiens)
PF04189
(Gcd10p)
4 VAL B 237
PRO B 232
GLY B 233
TYR B 231
A  N  43 ( 4.8A)
None
None
None
1.42A 5x80A-5ccxB:
undetectable
5x80B-5ccxB:
undetectable
5x80A-5ccxB:
14.89
5x80B-5ccxB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5


(Homo sapiens)
PF00005
(ABC_tran)
PF01061
(ABC2_membrane)
4 VAL A 534
PRO A 431
GLY A 434
TYR A 432
None
1.13A 5x80A-5do7A:
0.2
5x80B-5do7A:
0.0
5x80A-5do7A:
13.24
5x80B-5do7A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE


(Legionella
pneumophila)
PF00156
(Pribosyltran)
4 VAL A 135
PRO A  55
GLY A 165
TYR A 164
None
1.10A 5x80A-5esxA:
undetectable
5x80B-5esxA:
undetectable
5x80A-5esxA:
22.44
5x80B-5esxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewy PUTATIVE
ADP-RIBOSYLTRANSFERA
SE SCABIN


(Streptomyces
scabiei)
no annotation 4 VAL A  59
PRO A 114
GLY A 165
TYR A 115
None
1.45A 5x80A-5ewyA:
undetectable
5x80B-5ewyA:
undetectable
5x80A-5ewyA:
19.29
5x80B-5ewyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR


(Acinetobacter
baumannii)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 VAL A 672
PRO A 616
GLY A 642
TYR A 641
None
1.37A 5x80A-5fr8A:
undetectable
5x80B-5fr8A:
undetectable
5x80A-5fr8A:
11.48
5x80B-5fr8A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1


(Homo sapiens)
PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M)
4 VAL A 457
PRO A 426
GLY A 428
TYR A 425
None
1.17A 5x80A-5hp5A:
undetectable
5x80B-5hp5A:
undetectable
5x80A-5hp5A:
15.77
5x80B-5hp5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899


(Dyadobacter
fermentans)
PF13088
(BNR_2)
4 VAL A 353
PRO A 331
GLY A 333
TYR A 327
None
1.34A 5x80A-5hx0A:
undetectable
5x80B-5hx0A:
undetectable
5x80A-5hx0A:
18.42
5x80B-5hx0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxw L-AMINO ACID
DEAMINASE


(Proteus
vulgaris)
PF01266
(DAO)
4 VAL A 236
PRO A 428
GLY A 429
TYR A 427
None
1.39A 5x80A-5hxwA:
undetectable
5x80B-5hxwA:
undetectable
5x80A-5hxwA:
16.37
5x80B-5hxwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
4 VAL A 330
PRO A 366
GLY A 325
TYR A 269
None
1.09A 5x80A-5j78A:
0.5
5x80B-5j78A:
0.7
5x80A-5j78A:
17.42
5x80B-5j78A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN


(Sphingopyxis
alaskensis)
PF00326
(Peptidase_S9)
4 VAL A 626
ARG A 721
PRO A 719
GLY A 652
None
1.10A 5x80A-5jrlA:
undetectable
5x80B-5jrlA:
undetectable
5x80A-5jrlA:
15.14
5x80B-5jrlA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3z POLYKETIDE
KETOREDUCTASE SIMC7


(Streptomyces
antibioticus)
PF13460
(NAD_binding_10)
4 ARG A 215
PRO A 156
GLY A 157
TYR A 155
None
0.92A 5x80A-5l3zA:
undetectable
5x80B-5l3zA:
undetectable
5x80A-5l3zA:
26.71
5x80B-5l3zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93


(Porphyromonas
gingivalis)
no annotation 4 VAL A 774
PRO A 696
GLY A 706
TYR A 703
None
1.43A 5x80A-5m11A:
undetectable
5x80B-5m11A:
undetectable
5x80A-5m11A:
11.81
5x80B-5m11A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 VAL A 243
PRO A 174
GLY A 181
TYR A 221
None
1.13A 5x80A-5neuA:
undetectable
5x80B-5neuA:
undetectable
5x80A-5neuA:
14.82
5x80B-5neuA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa)
PF03537
(Glyco_hydro_114)
4 VAL A  72
PRO A  93
GLY A 156
TYR A 154
None
1.38A 5x80A-5tcbA:
undetectable
5x80B-5tcbA:
undetectable
5x80A-5tcbA:
28.99
5x80B-5tcbA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8


(Homo sapiens)
PF00850
(Hist_deacetyl)
4 VAL A 345
ARG A 313
GLY A 341
TYR A 340
None
1.39A 5x80A-5vi6A:
undetectable
5x80B-5vi6A:
undetectable
5x80A-5vi6A:
18.38
5x80B-5vi6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN


(Homo sapiens)
no annotation 4 VAL A 550
PRO A 507
GLY A 505
TYR A 553
None
1.44A 5x80A-6bgzA:
undetectable
5x80B-6bgzA:
undetectable
5x80A-6bgzA:
21.74
5x80B-6bgzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE


(Paracoccus
denitrificans)
no annotation 4 VAL A 524
ARG A 523
GLY A 242
TYR A 243
None
1.35A 5x80A-6es9A:
0.8
5x80B-6es9A:
0.9
5x80A-6es9A:
23.90
5x80B-6es9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1


(Saccharomyces
cerevisiae)
no annotation 4 VAL A 266
ARG A 269
PRO A 264
GLY A  82
None
1.45A 5x80A-6f42A:
undetectable
5x80B-6f42A:
undetectable
5x80A-6f42A:
20.75
5x80B-6f42A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gmb HYDROXYACID OXIDASE
1


(Homo sapiens)
no annotation 4 VAL A 294
ARG A 295
PRO A 316
GLY A 314
None
FMN  A 506 ( 2.6A)
PG4  A 503 ( 3.7A)
FMN  A 506 (-3.4A)
1.06A 5x80A-6gmbA:
undetectable
5x80B-6gmbA:
0.0
5x80A-6gmbA:
18.45
5x80B-6gmbA:
18.45