SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7Q_A_ACRA1481
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dex | RHAMNOGALACTURONANACETYLESTERASE (Aspergillusaculeatus) |
PF13472(Lipase_GDSL_2) | 4 | SER A 98ARG A 50GLU A 105TYR A 100 | None | 1.30A | 5x7qA-1dexA:undetectable | 5x7qA-1dexA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g38 | MODIFICATIONMETHYLASE TAQI (Thermusaquaticus) |
PF07669(Eco57I)PF12950(TaqI_C) | 4 | SER A 370ARG A 406GLU A 408TYR A 409 | None | 1.49A | 5x7qA-1g38A:0.0 | 5x7qA-1g38A:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0n | XANTHAN LYASE (Bacillus sp.GL1) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 4 | TRP A 199SER A 258GLU A 310TYR A 255 | NoneCEG A 780 ( 4.7A)CEG A 780 ( 4.3A)CEG A 780 (-4.4A) | 1.32A | 5x7qA-1j0nA:3.8 | 5x7qA-1j0nA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcm | PHOSPHATIDYLINOSITOLTRANSFER PROTEINALPHA (Mus musculus) |
PF02121(IP_trans) | 4 | HIS A 127ARG A 8GLU A 6TYR A 194 | None | 1.11A | 5x7qA-1kcmA:0.0 | 5x7qA-1kcmA:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lln | ANTIVIRAL PROTEIN 3 (Phytolaccaamericana) |
PF00161(RIP) | 4 | SER A 116ARG A 127GLU A 121TYR A 117 | MLY A 115 ( 4.2A)NoneNoneNone | 1.43A | 5x7qA-1llnA:0.0 | 5x7qA-1llnA:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mk2 | SMAD 3 (Homo sapiens) |
PF03166(MH2) | 4 | SER A 235HIS A 398ARG A 372GLU A 396 | NoneNoneACY A 2 (-4.5A)None | 1.22A | 5x7qA-1mk2A:0.0 | 5x7qA-1mk2A:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mz5 | SIALIDASE (Trypanosomarangeli) |
PF13385(Laminin_G_3)PF13859(BNR_3) | 4 | SER A 344ARG A 36GLU A 358TYR A 343 | None | 1.18A | 5x7qA-1mz5A:5.7 | 5x7qA-1mz5A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw1 | CHOLINE KINASE (49.2KD) (Caenorhabditiselegans) |
PF01633(Choline_kinase) | 4 | TRP A 201HIS A 121GLU A 303TYR A 304 | None | 1.33A | 5x7qA-1nw1A:undetectable | 5x7qA-1nw1A:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7f | CAMP-DEPENDENT RAP1GUANINE-NUCLEOTIDEEXCHANGE FACTOR (Mus musculus) |
PF00027(cNMP_binding)PF00610(DEP) | 4 | HIS A 359ARG A 429GLU A 357TYR A 377 | None | 1.44A | 5x7qA-1o7fA:2.3 | 5x7qA-1o7fA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ru4 | PECTATE LYASE (Dickeyachrysanthemi) |
PF13229(Beta_helix) | 4 | TRP A 229HIS A 172ARG A 116GLU A 148 | None | 1.30A | 5x7qA-1ru4A:undetectable | 5x7qA-1ru4A:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vli | SPORE COATPOLYSACCHARIDEBIOSYNTHESIS PROTEINSPSE (Bacillussubtilis) |
PF03102(NeuB)PF08666(SAF) | 4 | SER A 130ARG A 327GLU A 132TYR A 131 | None | 1.50A | 5x7qA-1vliA:1.5 | 5x7qA-1vliA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a1l | PHOSPHATIDYLINOSITOLTRANSFER PROTEINBETA ISOFORM (Rattusnorvegicus) |
PF02121(IP_trans) | 4 | HIS A 126ARG A 8GLU A 6TYR A 193 | None | 1.07A | 5x7qA-2a1lA:undetectable | 5x7qA-2a1lA:11.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8i | THREONINE ASPARTASE1 (Homo sapiens) |
PF01112(Asparaginase_2) | 4 | SER A 134ARG A 172GLU A 168TYR A 171 | None | 0.97A | 5x7qA-2a8iA:undetectable | 5x7qA-2a8iA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lqt | COILED-COIL-HELIX-COILED-COIL-HELIXDOMAIN-CONTAININGPROTEIN 7 (Homo sapiens) |
no annotation | 4 | SER A 23ARG A 43GLU A 19TYR A 40 | None | 1.45A | 5x7qA-2lqtA:undetectable | 5x7qA-2lqtA:4.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpj | KELCH-LIKE PROTEIN12 (Homo sapiens) |
PF01344(Kelch_1) | 4 | SER A 464ARG A 392GLU A 417TYR A 434 | NoneNoneACT A1569 (-3.8A)None | 1.09A | 5x7qA-2vpjA:4.0 | 5x7qA-2vpjA:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xt6 | 2-OXOGLUTARATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00198(2-oxoacid_dh)PF00676(E1_dh)PF02779(Transket_pyr)PF16870(OxoGdeHyase_C) | 4 | SER A 963ARG A 897GLU A 959TYR A 962 | None | 1.46A | 5x7qA-2xt6A:undetectable | 5x7qA-2xt6A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff6 | ACETYL-COACARBOXYLASE 2 (Homo sapiens) |
PF01039(Carboxyl_trans) | 4 | SER A1919ARG A2146GLU A1923TYR A1922 | None | 1.39A | 5x7qA-3ff6A:undetectable | 5x7qA-3ff6A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fgt | PUTATIVEPHOSPHOLIPASE B-LIKE2 28 KDA FORM (Mus musculus) |
PF04916(Phospholip_B) | 4 | SER A 68HIS A 85ARG A 79GLU A 81 | None | 1.31A | 5x7qA-3fgtA:undetectable | 5x7qA-3fgtA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hxk | SUGAR HYDROLASE (Lactococcuslactis) |
PF00326(Peptidase_S9) | 4 | TRP A 161SER A 127HIS A 231GLU A 61 | None | 1.39A | 5x7qA-3hxkA:undetectable | 5x7qA-3hxkA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9t | PUTATIVE PEPTIDASE (Clostridiumacetobutylicum) |
PF09940(DUF2172)PF16221(HTH_47)PF16254(DUF4910) | 4 | HIS A 103ARG A 78GLU A 154TYR A 76 | None | 1.30A | 5x7qA-3k9tA:undetectable | 5x7qA-3k9tA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oon | OUTER MEMBRANEPROTEIN (TPN50) (Borreliellaburgdorferi) |
PF00691(OmpA) | 4 | SER A 335HIS A 332ARG A 340GLU A 336 | None | 1.48A | 5x7qA-3oonA:undetectable | 5x7qA-3oonA:6.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 4 | TRP A 717SER A 679ARG A 635TYR A 634 | NoneNoneSTU A 1 (-2.9A)None | 1.42A | 5x7qA-3ppzA:3.0 | 5x7qA-3ppzA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmh | YEAST CDC13 OB4 ([Candida]glabrata) |
no annotation | 4 | SER A 722ARG A 652GLU A 650TYR A 675 | None | 1.25A | 5x7qA-3rmhA:undetectable | 5x7qA-3rmhA:7.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2a | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF00047(ig) | 4 | SER R 311ARG R 222GLU R 251TYR R 221 | None | 1.49A | 5x7qA-3v2aR:undetectable | 5x7qA-3v2aR:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwv | TTC1975 PEPTIDASE (Meiothermustaiwanensis) |
PF13654(AAA_32) | 4 | SER A 316ARG A 276GLU A 269TYR A 271 | None | 1.49A | 5x7qA-4fwvA:undetectable | 5x7qA-4fwvA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l6y | PROTEIN REGULATOR OFCYTOKINESIS 1 (Homo sapiens) |
PF03999(MAP65_ASE1) | 4 | TRP A 436HIS A 439ARG A 392GLU A 369 | None | 1.41A | 5x7qA-4l6yA:undetectable | 5x7qA-4l6yA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9a | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.1393C (Streptococcusmutans) |
no annotation | 4 | SER A 233ARG A 226GLU A 229TYR A 230 | None | 1.48A | 5x7qA-4l9aA:undetectable | 5x7qA-4l9aA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p2b | GLUTAMINEAMINOACYL-TRNASYNTHETASE (Toxoplasmagondii) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C) | 4 | SER A 114HIS A 212GLU A 88TYR A 112 | None | 1.22A | 5x7qA-4p2bA:undetectable | 5x7qA-4p2bA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4sli | INTRAMOLECULARTRANS-SIALIDASE (Macrobdelladecora) |
PF02973(Sialidase)PF13088(BNR_2) | 4 | SER A 714ARG A 293GLU A 729TYR A 713 | NoneCNP A 760 (-3.0A)NoneCNP A 760 (-4.0A) | 1.18A | 5x7qA-4sliA:4.0 | 5x7qA-4sliA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkc | MANNOSE RECOGNIZINGLECTIN (Marasmiusoreades) |
no annotation | 4 | HIS A 4ARG A 32GLU A 30TYR A 2 | None | 1.04A | 5x7qA-4tkcA:undetectable | 5x7qA-4tkcA:7.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x28 | ACYL-COADEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | SER A 4ARG A 13GLU A 10TYR A 5 | None | 1.35A | 5x7qA-4x28A:undetectable | 5x7qA-4x28A:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x6k | ANHYDROSIALIDASE ([Ruminococcus]gnavus) |
PF13088(BNR_2) | 4 | SER A 678ARG A 257GLU A 693TYR A 677 | None3XR A 802 (-3.0A)None3XR A 802 (-4.2A) | 1.19A | 5x7qA-4x6kA:undetectable | 5x7qA-4x6kA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhb | SIALIDASE B (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 4 | SER A 654ARG A 245GLU A 669TYR A 653 | NoneNHE A 702 (-2.7A)NoneNHE A 702 (-4.8A) | 1.19A | 5x7qA-4xhbA:4.3 | 5x7qA-4xhbA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yw5 | NEURAMINIDASE C (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 4 | SER A 696ARG A 290GLU A 711TYR A 695 | NoneG39 A 801 (-2.6A)NoneG39 A 801 (-4.4A) | 1.19A | 5x7qA-4yw5A:4.0 | 5x7qA-4yw5A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b47 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEALPHA SUBUNIT (Sulfurisphaeratokodaii) |
PF01558(POR)PF01855(POR_N)PF17147(PFOR_II) | 4 | SER A 415HIS A 381ARG A 38TYR A 414 | None | 1.39A | 5x7qA-5b47A:undetectable | 5x7qA-5b47A:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b47 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEALPHA SUBUNIT (Sulfurisphaeratokodaii) |
PF01558(POR)PF01855(POR_N)PF17147(PFOR_II) | 4 | TRP A 329HIS A 470ARG A 444TYR A 465 | None | 1.18A | 5x7qA-5b47A:undetectable | 5x7qA-5b47A:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b48 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEALPHA SUBUNIT (Sulfurisphaeratokodaii) |
PF01558(POR)PF01855(POR_N) | 4 | TRP A 329HIS A 470ARG A 444TYR A 465 | None | 1.21A | 5x7qA-5b48A:undetectable | 5x7qA-5b48A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cgl | ADENOSINEMONOPHOSPHATE-PROTEIN TRANSFERASE NMFIC (Neisseriameningitidis) |
PF02661(Fic) | 4 | TRP A 135SER A 182GLU A 186TYR A 185 | NoneNonePEG A 201 (-3.9A)None | 1.47A | 5x7qA-5cglA:undetectable | 5x7qA-5cglA:9.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5en4 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14 (Homo sapiens) |
PF13561(adh_short_C2) | 4 | SER A 173ARG A 130GLU A 172TYR A 175 | None | 1.28A | 5x7qA-5en4A:2.0 | 5x7qA-5en4A:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ggg | PROTEINO-LINKED-MANNOSEBETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE1 (Homo sapiens) |
PF03071(GNT-I)PF15711(ILEI) | 4 | TRP A 206SER A 182ARG A 129TYR A 152 | None | 1.27A | 5x7qA-5gggA:2.8 | 5x7qA-5gggA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9d | FARNESYLPYROPHOSPHATESYNTHETASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 4 | SER A 61ARG A 16GLU A 62TYR A 65 | None | 1.41A | 5x7qA-5h9dA:undetectable | 5x7qA-5h9dA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohs | - (-) |
no annotation | 4 | TRP A 452HIS A 520GLU A 270TYR A 315 | NSQ A 709 (-4.9A)NSQ A 709 (-3.9A)NSQ A 709 (-2.6A)NSQ A 709 ( 4.8A) | 1.34A | 5x7qA-5ohsA:18.8 | 5x7qA-5ohsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqj | U6 SNRNAPHOSPHODIESTERASE (Saccharomycescerevisiae) |
PF09749(HVSL) | 4 | SER A 284HIS A 283ARG A 286TYR A 277 | NoneNoneACT A 307 (-3.5A)None | 1.30A | 5x7qA-5uqjA:undetectable | 5x7qA-5uqjA:10.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w99 | PBTD (Planobisporarosea) |
no annotation | 4 | HIS A 311ARG A 202GLU A 198TYR A 201 | None | 1.01A | 5x7qA-5w99A:undetectable | 5x7qA-5w99A:5.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 6 | TRP A1148SER A1189HIS A1191ARG A1220GLU A1222TYR A1261 | None | 0.24A | 5x7qA-5x7sA:45.6 | 5x7qA-5x7sA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6am0 | KLLA0F23980P (Kluyveromyceslactis) |
no annotation | 4 | TRP A 49HIS A 194ARG A 147GLU A 151 | 6VQ A 302 (-3.4A)6VQ A 302 (-4.0A)NoneNone | 1.38A | 5x7qA-6am0A:undetectable | 5x7qA-6am0A:5.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bog | RNAPOLYMERASE-ASSOCIATED PROTEIN RAPA (Escherichiacoli) |
no annotation | 4 | TRP A 67SER A 63HIS A 64ARG A 98 | None | 1.12A | 5x7qA-6bogA:undetectable | 5x7qA-6bogA:4.75 |