SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_B_ACRB1471

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 ASP A 356
GLY A 331
LEU A 295
TYR A 334
THR A 131
 None
None
XPL  A 202 ( 4.8A)
None
XPL  A 202 ( 4.5A)
 1.42A 5x7pB-1l2qA:
0.3		 5x7pB-1l2qA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8f ENDOGLUCANASE

(Melanocarpus
albomyces) 		PF02015
(Glyco_hydro_45) 		5 ASP A  10
GLY A 129
TYR A   8
ASN A 178
THR A   6
 None
 1.35A 5x7pB-1l8fA:
0.0		 5x7pB-1l8fA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda AMICYANIN
METHYLAMINE
DEHYDROGENASE (LIGHT
SUBUNIT)

(Paracoccus
denitrificans) 		PF00127
(Copper-bind)
PF02975
(Me-amine-dh_L) 		5 ASP L 113
GLY L 111
HIS A  56
ASN A  54
THR A  93
 None
 1.37A 5x7pB-1mdaL:
0.0		 5x7pB-1mdaL:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ARG B 382
ASP B 283
GLY B 256
GLU B 253
ARG B 172
 None
 1.42A 5x7pB-1tqyB:
0.8		 5x7pB-1tqyB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eng ENDOGLUCANASE V

(Humicola
insolens) 		PF02015
(Glyco_hydro_45) 		5 ASP A  10
GLY A 130
TYR A   8
ASN A 179
THR A   6
 None
 1.34A 5x7pB-2engA:
0.0		 5x7pB-2engA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 ARG A 834
ASP A 659
GLY A 732
TYR A 803
THR A 825
 None
 1.05A 5x7pB-2g28A:
0.4		 5x7pB-2g28A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		5 ARG A 144
ASP A  51
GLY A  81
LEU A  83
ASN A 203
 None
None
None
None
PQQ  A4331 (-3.9A)
 1.20A 5x7pB-3dasA:
0.0		 5x7pB-3dasA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 ASP A 250
LEU A  95
ARG A 169
ASN A 128
THR A 130
 UNL  A   1 ( 2.9A)
UNL  A   1 ( 4.5A)
UNL  A   1 ( 2.8A)
None
None
 1.26A 5x7pB-3l49A:
1.7		 5x7pB-3l49A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ASP A 500
GLY A 496
GLU A 494
ASN A 452
HIS A 493
 PGE  A1684 ( 3.8A)
None
RDF  A1665 (-2.5A)
RDF  A1665 (-3.2A)
ZN  A1664 ( 3.4A)
 1.32A 5x7pB-3zukA:
0.7		 5x7pB-3zukA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 ASP A  46
GLY A 198
HIS A  79
THR A 146
HIS A 149
 None
None
ZN  A1001 (-3.3A)
None
None
 1.34A 5x7pB-4ad9A:
undetectable		 5x7pB-4ad9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		5 GLY C2245
LEU C2247
TYR C2208
ASN C2348
THR C2223
 None
 1.19A 5x7pB-4bgdC:
undetectable		 5x7pB-4bgdC:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i04 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		5 ARG A  49
ASP A 151
GLY A 147
GLU A 316
ARG A  60
 None
 1.20A 5x7pB-4i04A:
undetectable		 5x7pB-4i04A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		5 ARG A 354
GLY A  26
LEU A 357
TYR A 212
HIS A 209
 None
 1.37A 5x7pB-4ke4A:
undetectable		 5x7pB-4ke4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 ARG A  62
GLY A 109
LEU A 112
GLU A 118
HIS A 229
 None
 1.27A 5x7pB-5fw4A:
undetectable		 5x7pB-5fw4A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4u ENDO-BETA-1,4-GLUCAN
ASE

(Cryptopygus
antarcticus) 		PF02015
(Glyco_hydro_45) 		5 ASP A  13
GLY A 131
TYR A  11
ASN A 183
THR A   9
 None
 1.45A 5x7pB-5h4uA:
undetectable		 5x7pB-5h4uA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wut ULAM111

(Flavobacterium
sp.) 		no annotation 5 GLY A  64
GLU A  63
TYR A  67
ASN A  48
THR A  68
 None
 1.26A 5x7pB-5wutA:
4.2		 5x7pB-5wutA:
5.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		12 ARG A 362
ARG A 368
ASP A1160
GLY A1162
LEU A1165
GLU A1169
ARG A1177
TYR A1179
HIS A1181
ASN A1213
THR A1269
HIS A1271
 None
None
None
None
None
None
None
None
None
MES  A1707 (-3.4A)
None
None
 0.61A 5x7pB-5x7sA:
58.3		 5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		7 ARG A 362
ASP A1160
GLY A1162
LEU A1165
GLU A1169
ARG A1177
HIS A1271
 None
 0.97A 5x7pB-5x7sA:
58.3		 5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		6 GLY A1170
GLU A1169
ARG A1177
ASN A1213
THR A1269
HIS A1271
 None
None
None
MES  A1707 (-3.4A)
None
None
 1.40A 5x7pB-5x7sA:
58.3		 5x7pB-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 5 ARG A  84
ASP A 374
LEU A  73
HIS A 313
THR A 318
 None
 1.42A 5x7pB-5y0qA:
1.4		 5x7pB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1
SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 ARG A1031
GLY C1242
GLU C1205
TYR C1200
ASN A1154
 None
 1.30A 5x7pB-6en4A:
undetectable		 5x7pB-6en4A:
4.83