SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_B_ACRB1431_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 HIS A  38
ASP A 241
GLY A 214
ASN A  33
None
0.91A 5x7pB-1bqgA:
0.0
5x7pB-1bqgA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola)
PF00155
(Aminotran_1_2)
4 HIS A  83
ASP A 293
TRP A  78
GLY A 289
None
1.37A 5x7pB-1c7oA:
0.0
5x7pB-1c7oA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I


(Mycobacterium
tuberculosis)
PF00809
(Pterin_bind)
4 HIS A 255
ASP A  86
GLY A  49
ASN A  13
MG  A 300 ( 4.0A)
PMM  A 301 (-3.2A)
None
MG  A 300 ( 2.9A)
1.24A 5x7pB-1eyeA:
0.0
5x7pB-1eyeA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE


(Escherichia
coli)
PF13378
(MR_MLE_C)
4 HIS A  32
ASP A 235
GLY A 208
ASN A  27
GKR  A 499 (-4.0A)
MG  A 498 ( 2.6A)
None
GKR  A 499 (-3.5A)
1.15A 5x7pB-1jctA:
0.0
5x7pB-1jctA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE


(Bacillus
intermedius)
PF00089
(Trypsin)
4 HIS A 186
ASP A 135
GLY A 134
ASN A 170
None
1.18A 5x7pB-1p3cA:
0.0
5x7pB-1p3cA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE


(Staphylococcus
aureus)
PF13365
(Trypsin_2)
4 HIS A 184
ASP A 137
GLY A 136
ASN A 168
None
1.24A 5x7pB-1wczA:
0.0
5x7pB-1wczA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1


(Saccharomyces
cerevisiae)
PF00809
(Pterin_bind)
PF01288
(HPPK)
4 HIS A 844
ASP A 636
GLY A 593
ASN A 551
PMM  A1865 (-4.0A)
PMM  A1865 (-3.3A)
None
PMM  A1865 ( 3.8A)
1.19A 5x7pB-2bmbA:
0.0
5x7pB-2bmbA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi)
PF02156
(Glyco_hydro_26)
4 ASP A 246
TRP A 217
GLY A 220
ASN A 176
None
1.49A 5x7pB-2bvtA:
2.2
5x7pB-2bvtA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea)
PF00246
(Peptidase_M14)
4 HIS A 196
ASP A 256
GLY A 252
ASN A 144
ZN  A 625 (-3.3A)
None
None
None
1.48A 5x7pB-2c1cA:
0.0
5x7pB-2c1cA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwa SINGLE-STRAND
BINDING PROTEIN


(Thermus
thermophilus)
PF00436
(SSB)
4 HIS A 171
ASP A 102
GLY A  80
ASN A   6
None
0.95A 5x7pB-2cwaA:
undetectable
5x7pB-2cwaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE


(Bacteroides
thetaiotaomicron)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase)
4 HIS A  36
ASP A  96
GLY A  99
ASN A  34
None
1.38A 5x7pB-2j4gA:
3.5
5x7pB-2j4gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwo HISTONE PEPTIDE
ZINC FINGER PROTEIN
DPF3


(Homo sapiens)
PF00628
(PHD)
no annotation
4 HIS B  18
ASP A 263
TRP A 311
GLY A 291
SAC  B   1 ( 4.9A)
SAC  B   1 ( 2.8A)
None
SAC  B   1 ( 4.9A)
1.33A 5x7pB-2kwoB:
undetectable
5x7pB-2kwoB:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET


(Pyrococcus
horikoshii)
PF00534
(Glycos_transf_1)
4 HIS A 273
TRP A 279
GLY A 269
ASN A 300
None
None
UPG  A1415 (-2.9A)
None
1.39A 5x7pB-2xa2A:
3.0
5x7pB-2xa2A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A


(Brevibacillus
brevis)
PF00668
(Condensation)
4 HIS A 116
ASP A 396
GLY A 394
ASN A 400
None
1.37A 5x7pB-2xhgA:
undetectable
5x7pB-2xhgA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2


(Homo sapiens)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
4 HIS X 327
ASP X 607
GLY X 334
ASN X 627
None
1.21A 5x7pB-2zkmX:
2.2
5x7pB-2zkmX:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Pseudomonas
syringae group
genomosp. 3)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 HIS A  97
ASP A 205
GLY A 204
ASN A  94
None
1.25A 5x7pB-3dtyA:
2.2
5x7pB-3dtyA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 HIS A 178
ASP A  89
TRP A 170
GLY A  93
None
1.32A 5x7pB-3g25A:
undetectable
5x7pB-3g25A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcx FAB E HEAVY CHAIN

(Rattus
norvegicus)
PF07686
(V-set)
4 HIS H 136
ASP H 157
GLY H 150
ASN H 165
None
1.42A 5x7pB-3jcxH:
undetectable
5x7pB-3jcxH:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE


(Burkholderia
mallei)
PF00246
(Peptidase_M14)
4 HIS A 119
ASP A 218
GLY A 219
ASN A 214
GOL  A 389 (-3.9A)
None
None
None
1.31A 5x7pB-3k2kA:
2.9
5x7pB-3k2kA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2m GALECTIN-1

(Rattus
norvegicus)
PF00337
(Gal-bind_lectin)
4 HIS A  52
ASP A 125
GLY A 124
ASN A  46
LAT  A 999 (-3.9A)
None
None
LAT  A 999 (-4.1A)
1.41A 5x7pB-3m2mA:
undetectable
5x7pB-3m2mA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF13378
(MR_MLE_C)
4 HIS A  27
ASP A 231
GLY A 204
ASN A  22
SO4  A 450 (-4.1A)
None
None
SO4  A 450 (-3.2A)
1.11A 5x7pB-3mznA:
undetectable
5x7pB-3mznA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE


(Burkholderia
lata)
PF13378
(MR_MLE_C)
4 HIS A  36
ASP A 255
GLY A 228
ASN A  31
CO3  A 477 (-4.0A)
MG  A 476 (-2.8A)
None
CO3  A 477 ( 3.8A)
1.12A 5x7pB-3nxlA:
undetectable
5x7pB-3nxlA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli)
PF01048
(PNP_UDP_1)
4 HIS A 163
ASP A 101
GLY A 110
ASN A 164
None
1.33A 5x7pB-3o4vA:
undetectable
5x7pB-3o4vA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE


(Thermoplasma
acidophilum)
PF01494
(FAD_binding_3)
4 HIS A 339
ASP A 283
GLY A 282
ASN A 298
None
FAD  A 501 (-2.7A)
FAD  A 501 (-3.5A)
EDO  A 509 ( 3.4A)
1.34A 5x7pB-3oz2A:
undetectable
5x7pB-3oz2A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Ralstonia
pickettii)
PF13378
(MR_MLE_C)
4 HIS A  32
ASP A 251
GLY A 224
ASN A  27
GKR  A 472 (-3.9A)
MG  A 471 ( 2.6A)
None
GKR  A 472 (-3.5A)
1.11A 5x7pB-3p0wA:
undetectable
5x7pB-3p0wA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Actinobacillus
succinogenes)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 HIS A  33
ASP A 236
GLY A 209
ASN A  28
GKR  A 457 (-3.8A)
MG  A 456 ( 2.7A)
None
GKR  A 457 (-3.4A)
1.15A 5x7pB-3pfrA:
undetectable
5x7pB-3pfrA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soz CYTOPLASMIC PROTEIN
STM1381


(Salmonella
enterica)
PF07090
(GATase1_like)
4 HIS A 220
ASP A  75
TRP A 221
GLY A 115
GOL  A1001 (-3.6A)
GOL  A1001 (-3.1A)
GOL  A1001 (-4.0A)
None
1.49A 5x7pB-3sozA:
undetectable
5x7pB-3sozA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Coxiella
burnetii)
PF00275
(EPSP_synthase)
4 HIS A  25
ASP A 233
GLY A  19
ASN A  49
None
1.43A 5x7pB-3tr1A:
undetectable
5x7pB-3tr1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE


(Coxiella
burnetii)
PF00809
(Pterin_bind)
4 HIS A 274
ASP A 111
GLY A  69
ASN A  35
CL  A 315 (-4.4A)
PT1  A1001 ( 3.4A)
None
CL  A 315 (-3.6A)
1.14A 5x7pB-3tr9A:
3.3
5x7pB-3tr9A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum)
PF13378
(MR_MLE_C)
4 HIS A  29
ASP A 220
GLY A 193
ASN A  24
SO4  A 424 (-3.8A)
MG  A 425 ( 2.4A)
None
SO4  A 424 (-3.8A)
1.11A 5x7pB-3va8A:
undetectable
5x7pB-3va8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE


(Mycolicibacterium
smegmatis)
PF13378
(MR_MLE_C)
4 HIS A  30
ASP A 222
GLY A 195
ASN A  25
ACT  A 504 (-4.0A)
NA  A 502 (-2.9A)
None
ACT  A 504 (-3.9A)
1.12A 5x7pB-3vdgA:
undetectable
5x7pB-3vdgA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE


(Pseudomonas
aeruginosa)
PF00246
(Peptidase_M14)
4 HIS A 118
ASP A 210
GLY A 211
ASN A 206
None
1.36A 5x7pB-4a39A:
undetectable
5x7pB-4a39A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE


(Burkholderia
cenocepacia)
PF00246
(Peptidase_M14)
4 HIS A 119
ASP A 218
GLY A 219
ASN A 214
None
1.32A 5x7pB-4b6zA:
2.9
5x7pB-4b6zA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Thermobispora
bispora)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 HIS A  25
ASP A 217
GLY A 190
ASN A  20
PO4  A 501 (-4.0A)
None
None
PO4  A 501 (-3.6A)
1.10A 5x7pB-4dhgA:
undetectable
5x7pB-4dhgA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
4 HIS A 858
ASP A 866
GLY A 865
ASN A 862
None
1.05A 5x7pB-4fddA:
undetectable
5x7pB-4fddA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE


(Actinobacillus
succinogenes)
PF13378
(MR_MLE_C)
4 HIS A  28
ASP A 231
GLY A 204
ASN A  23
SO4  A 501 (-4.2A)
NA  A 502 (-2.3A)
None
SO4  A 501 (-3.3A)
1.10A 5x7pB-4g8tA:
undetectable
5x7pB-4g8tA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE


(Klebsiella
pneumoniae)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 HIS A  87
ASP A 190
GLY A 189
ASN A  84
None
1.19A 5x7pB-4gqaA:
undetectable
5x7pB-4gqaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN


(Escherichia
coli)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 HIS C  31
ASP C 234
GLY C 207
ASN C  26
CIT  C 501 (-3.9A)
None
None
CIT  C 501 (-3.3A)
1.18A 5x7pB-4gypC:
undetectable
5x7pB-4gypC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE


(Pseudomonas
mendocina)
PF13378
(MR_MLE_C)
4 HIS A  34
ASP A 252
GLY A 225
ASN A  29
GOL  A 502 (-4.3A)
None
None
GOL  A 502 (-3.5A)
1.09A 5x7pB-4hn8A:
undetectable
5x7pB-4hn8A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE


(Acidaminococcus
intestini)
PF13378
(MR_MLE_C)
4 HIS A  27
ASP A 231
GLY A 204
ASN A  22
CL  A 502 (-4.2A)
None
None
None
1.13A 5x7pB-4hyrA:
undetectable
5x7pB-4hyrA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oij C-C MOTIF CHEMOKINE
1


(Homo sapiens)
PF00048
(IL8)
4 HIS A  68
ASP A  54
GLY A  39
ASN A  30
SO4  A 105 ( 3.9A)
None
None
SO4  A 105 (-3.6A)
1.13A 5x7pB-4oijA:
undetectable
5x7pB-4oijA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p27 VENOM ALLERGEN-LIKE
(VAL) 4 PROTEIN


(Schistosoma
mansoni)
PF00188
(CAP)
4 HIS A  15
ASP A 144
GLY A  75
ASN A  77
None
1.43A 5x7pB-4p27A:
undetectable
5x7pB-4p27A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167)
PF00232
(Glyco_hydro_1)
4 HIS A  48
ASP A  60
TRP A  44
GLY A  36
None
1.23A 5x7pB-4r27A:
2.5
5x7pB-4r27A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE


(Rhizobium etli)
PF02826
(2-Hacid_dh_C)
4 HIS A 113
ASP A 121
GLY A 119
ASN A 276
None
1.29A 5x7pB-4xcvA:
undetectable
5x7pB-4xcvA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
4 HIS A  86
ASP A 209
GLY A 174
ASN A 158
ZN  A 601 (-3.1A)
None
None
None
1.46A 5x7pB-4xwtA:
2.9
5x7pB-4xwtA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT


(Candidatus
Kuenenia
stuttgartiensis)
no annotation 4 HIS A 453
ASP A 246
GLY A 235
ASN A 432
None
0.99A 5x7pB-5c2vA:
undetectable
5x7pB-5c2vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 ASP A 998
TRP A1051
GLY A1081
ASN A1083
GLC  A1113 (-4.0A)
GLC  A1112 (-3.6A)
GLC  A1113 (-3.2A)
GLC  A1112 (-2.9A)
0.91A 5x7pB-5f7uA:
22.7
5x7pB-5f7uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 HIS A 985
TRP A1051
GLY A 996
ASN A1083
GLC  A1112 (-3.9A)
GLC  A1112 (-3.6A)
GLC  A1112 (-3.6A)
GLC  A1112 (-2.9A)
1.11A 5x7pB-5f7uA:
22.7
5x7pB-5f7uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 HIS A 985
TRP A1051
GLY A1081
ASN A1083
GLC  A1112 (-3.9A)
GLC  A1112 (-3.6A)
GLC  A1113 (-3.2A)
GLC  A1112 (-2.9A)
0.51A 5x7pB-5f7uA:
22.7
5x7pB-5f7uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN


(Streptomyces
mobaraensis)
no annotation 4 HIS A 318
ASP A 322
GLY A 323
ASN A 319
None
CA  A1351 (-2.3A)
None
None
1.14A 5x7pB-5fzpA:
undetectable
5x7pB-5fzpA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S6E


(Pyrococcus
abyssi)
PF01092
(Ribosomal_S6e)
4 HIS G  79
ASP G  36
GLY G  35
ASN G 110
C  21402 ( 3.5A)
None
C  21404 ( 3.7A)
U  21403 ( 2.5A)
1.25A 5x7pB-5jb3G:
undetectable
5x7pB-5jb3G:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5moy BOTULINUM NEUROTOXIN
TYPE A


(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
4 ASP A1289
TRP A1101
GLY A1292
ASN A1012
None
1.37A 5x7pB-5moyA:
6.4
5x7pB-5moyA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u04 ZIKA VIRUS NS5 RDRP

(Zika virus)
PF00972
(Flavi_NS5)
4 HIS A 714
ASP A 846
GLY A 842
ASN A 716
ZN  A1001 (-3.2A)
None
None
ZN  A1001 ( 4.6A)
1.18A 5x7pB-5u04A:
undetectable
5x7pB-5u04A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE


(Marinomonas
mediterranea)
no annotation 4 ASP A 158
TRP A 227
GLY A 172
ASN A 176
None
1.23A 5x7pB-5x32A:
undetectable
5x7pB-5x32A:
4.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE


(Paenibacillus
sp. 598K)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110)
5 HIS A 876
ASP A 889
TRP A 943
GLY A 975
ASN A 977
None
0.17A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY


(Paracoccus
laeviglucosivorans)
no annotation 4 HIS A  88
ASP A 191
GLY A 190
ASN A  85
NAI  A 401 (-3.8A)
8S0  A 402 (-4.3A)
None
NAI  A 401 (-3.7A)
1.23A 5x7pB-5yapA:
undetectable
5x7pB-5yapA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdz THYMIDYLATE SYNTHASE

(Escherichia
coli)
no annotation 4 HIS A 212
ASP A  20
GLY A  25
ASN A 211
None
1.34A 5x7pB-6cdzA:
undetectable
5x7pB-6cdzA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6day DIHYDROPTEROATE
SYNTHASE


(Xanthomonas
albilineans)
no annotation 4 HIS A 263
ASP A 101
GLY A  63
ASN A  27
SO4  A 403 (-4.2A)
None
None
SO4  A 403 (-3.1A)
1.23A 5x7pB-6dayA:
2.1
5x7pB-6dayA:
5.00