SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_B_ACRB1431_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqg | D-GLUCARATEDEHYDRATASE (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | HIS A 38ASP A 241GLY A 214ASN A 33 | None | 0.91A | 5x7pB-1bqgA:0.0 | 5x7pB-1bqgA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7o | CYSTALYSIN (Treponemadenticola) |
PF00155(Aminotran_1_2) | 4 | HIS A 83ASP A 293TRP A 78GLY A 289 | None | 1.37A | 5x7pB-1c7oA:0.0 | 5x7pB-1c7oA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eye | DIHYDROPTEROATESYNTHASE I (Mycobacteriumtuberculosis) |
PF00809(Pterin_bind) | 4 | HIS A 255ASP A 86GLY A 49ASN A 13 | MG A 300 ( 4.0A)PMM A 301 (-3.2A)None MG A 300 ( 2.9A) | 1.24A | 5x7pB-1eyeA:0.0 | 5x7pB-1eyeA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jct | GLUCARATEDEHYDRATASE (Escherichiacoli) |
PF13378(MR_MLE_C) | 4 | HIS A 32ASP A 235GLY A 208ASN A 27 | GKR A 499 (-4.0A) MG A 498 ( 2.6A)NoneGKR A 499 (-3.5A) | 1.15A | 5x7pB-1jctA:0.0 | 5x7pB-1jctA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3c | GLUTAMYL-ENDOPEPTIDASE (Bacillusintermedius) |
PF00089(Trypsin) | 4 | HIS A 186ASP A 135GLY A 134ASN A 170 | None | 1.18A | 5x7pB-1p3cA:0.0 | 5x7pB-1p3cA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcz | GLUTAMYLENDOPEPTIDASE (Staphylococcusaureus) |
PF13365(Trypsin_2) | 4 | HIS A 184ASP A 137GLY A 136ASN A 168 | None | 1.24A | 5x7pB-1wczA:0.0 | 5x7pB-1wczA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bmb | FOLIC ACID SYNTHESISPROTEIN FOL1 (Saccharomycescerevisiae) |
PF00809(Pterin_bind)PF01288(HPPK) | 4 | HIS A 844ASP A 636GLY A 593ASN A 551 | PMM A1865 (-4.0A)PMM A1865 (-3.3A)NonePMM A1865 ( 3.8A) | 1.19A | 5x7pB-2bmbA:0.0 | 5x7pB-2bmbA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvt | BETA-1,4-MANNANASE (Cellulomonasfimi) |
PF02156(Glyco_hydro_26) | 4 | ASP A 246TRP A 217GLY A 220ASN A 176 | None | 1.49A | 5x7pB-2bvtA:2.2 | 5x7pB-2bvtA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1c | CARBOXYPEPTIDASE B (Helicoverpa zea) |
PF00246(Peptidase_M14) | 4 | HIS A 196ASP A 256GLY A 252ASN A 144 | ZN A 625 (-3.3A)NoneNoneNone | 1.48A | 5x7pB-2c1cA:0.0 | 5x7pB-2c1cA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cwa | SINGLE-STRANDBINDING PROTEIN (Thermusthermophilus) |
PF00436(SSB) | 4 | HIS A 171ASP A 102GLY A 80ASN A 6 | None | 0.95A | 5x7pB-2cwaA:undetectable | 5x7pB-2cwaA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4g | HYALURONOGLUCOSAMINIDASE (Bacteroidesthetaiotaomicron) |
PF02838(Glyco_hydro_20b)PF07555(NAGidase) | 4 | HIS A 36ASP A 96GLY A 99ASN A 34 | None | 1.38A | 5x7pB-2j4gA:3.5 | 5x7pB-2j4gA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kwo | HISTONE PEPTIDEZINC FINGER PROTEINDPF3 (Homo sapiens) |
PF00628(PHD)no annotation | 4 | HIS B 18ASP A 263TRP A 311GLY A 291 | SAC B 1 ( 4.9A)SAC B 1 ( 2.8A)NoneSAC B 1 ( 4.9A) | 1.33A | 5x7pB-2kwoB:undetectable | 5x7pB-2kwoB:1.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xa2 | TREHALOSE-SYNTHASETRET (Pyrococcushorikoshii) |
PF00534(Glycos_transf_1) | 4 | HIS A 273TRP A 279GLY A 269ASN A 300 | NoneNoneUPG A1415 (-2.9A)None | 1.39A | 5x7pB-2xa2A:3.0 | 5x7pB-2xa2A:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhg | TYROCIDINESYNTHETASE A (Brevibacillusbrevis) |
PF00668(Condensation) | 4 | HIS A 116ASP A 396GLY A 394ASN A 400 | None | 1.37A | 5x7pB-2xhgA:undetectable | 5x7pB-2xhgA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zkm | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATEPHOSPHODIESTERASEBETA-2 (Homo sapiens) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 4 | HIS X 327ASP X 607GLY X 334ASN X 627 | None | 1.21A | 5x7pB-2zkmX:2.2 | 5x7pB-2zkmX:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dty | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Pseudomonassyringae groupgenomosp. 3) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | HIS A 97ASP A 205GLY A 204ASN A 94 | None | 1.25A | 5x7pB-3dtyA:2.2 | 5x7pB-3dtyA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g25 | GLYCEROL KINASE (Staphylococcusaureus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | HIS A 178ASP A 89TRP A 170GLY A 93 | None | 1.32A | 5x7pB-3g25A:undetectable | 5x7pB-3g25A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jcx | FAB E HEAVY CHAIN (Rattusnorvegicus) |
PF07686(V-set) | 4 | HIS H 136ASP H 157GLY H 150ASN H 165 | None | 1.42A | 5x7pB-3jcxH:undetectable | 5x7pB-3jcxH:6.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2k | PUTATIVECARBOXYPEPTIDASE (Burkholderiamallei) |
PF00246(Peptidase_M14) | 4 | HIS A 119ASP A 218GLY A 219ASN A 214 | GOL A 389 (-3.9A)NoneNoneNone | 1.31A | 5x7pB-3k2kA:2.9 | 5x7pB-3k2kA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m2m | GALECTIN-1 (Rattusnorvegicus) |
PF00337(Gal-bind_lectin) | 4 | HIS A 52ASP A 125GLY A 124ASN A 46 | LAT A 999 (-3.9A)NoneNoneLAT A 999 (-4.1A) | 1.41A | 5x7pB-3m2mA:undetectable | 5x7pB-3m2mA:6.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzn | GLUCARATEDEHYDRATASE (Chromohalobactersalexigens) |
PF13378(MR_MLE_C) | 4 | HIS A 27ASP A 231GLY A 204ASN A 22 | SO4 A 450 (-4.1A)NoneNoneSO4 A 450 (-3.2A) | 1.11A | 5x7pB-3mznA:undetectable | 5x7pB-3mznA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxl | GLUCARATEDEHYDRATASE (Burkholderialata) |
PF13378(MR_MLE_C) | 4 | HIS A 36ASP A 255GLY A 228ASN A 31 | CO3 A 477 (-4.0A) MG A 476 (-2.8A)NoneCO3 A 477 ( 3.8A) | 1.12A | 5x7pB-3nxlA:undetectable | 5x7pB-3nxlA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4v | MTA/SAH NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 4 | HIS A 163ASP A 101GLY A 110ASN A 164 | None | 1.33A | 5x7pB-3o4vA:undetectable | 5x7pB-3o4vA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oz2 | DIGERANYLGERANYLGLYCEROPHOSPHOLIPIDREDUCTASE (Thermoplasmaacidophilum) |
PF01494(FAD_binding_3) | 4 | HIS A 339ASP A 283GLY A 282ASN A 298 | NoneFAD A 501 (-2.7A)FAD A 501 (-3.5A)EDO A 509 ( 3.4A) | 1.34A | 5x7pB-3oz2A:undetectable | 5x7pB-3oz2A:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p0w | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Ralstoniapickettii) |
PF13378(MR_MLE_C) | 4 | HIS A 32ASP A 251GLY A 224ASN A 27 | GKR A 472 (-3.9A) MG A 471 ( 2.6A)NoneGKR A 472 (-3.5A) | 1.11A | 5x7pB-3p0wA:undetectable | 5x7pB-3p0wA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfr | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Actinobacillussuccinogenes) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | HIS A 33ASP A 236GLY A 209ASN A 28 | GKR A 457 (-3.8A) MG A 456 ( 2.7A)NoneGKR A 457 (-3.4A) | 1.15A | 5x7pB-3pfrA:undetectable | 5x7pB-3pfrA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3soz | CYTOPLASMIC PROTEINSTM1381 (Salmonellaenterica) |
PF07090(GATase1_like) | 4 | HIS A 220ASP A 75TRP A 221GLY A 115 | GOL A1001 (-3.6A)GOL A1001 (-3.1A)GOL A1001 (-4.0A)None | 1.49A | 5x7pB-3sozA:undetectable | 5x7pB-3sozA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr1 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Coxiellaburnetii) |
PF00275(EPSP_synthase) | 4 | HIS A 25ASP A 233GLY A 19ASN A 49 | None | 1.43A | 5x7pB-3tr1A:undetectable | 5x7pB-3tr1A:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr9 | DIHYDROPTEROATESYNTHASE (Coxiellaburnetii) |
PF00809(Pterin_bind) | 4 | HIS A 274ASP A 111GLY A 69ASN A 35 | CL A 315 (-4.4A)PT1 A1001 ( 3.4A)None CL A 315 (-3.6A) | 1.14A | 5x7pB-3tr9A:3.3 | 5x7pB-3tr9A:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va8 | PROBABLE DEHYDRATASE (Fusariumgraminearum) |
PF13378(MR_MLE_C) | 4 | HIS A 29ASP A 220GLY A 193ASN A 24 | SO4 A 424 (-3.8A) MG A 425 ( 2.4A)NoneSO4 A 424 (-3.8A) | 1.11A | 5x7pB-3va8A:undetectable | 5x7pB-3va8A:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vdg | PROBABLE GLUCARATEDEHYDRATASE (Mycolicibacteriumsmegmatis) |
PF13378(MR_MLE_C) | 4 | HIS A 30ASP A 222GLY A 195ASN A 25 | ACT A 504 (-4.0A) NA A 502 (-2.9A)NoneACT A 504 (-3.9A) | 1.12A | 5x7pB-3vdgA:undetectable | 5x7pB-3vdgA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a39 | METALLO-CARBOXYPEPTIDASE (Pseudomonasaeruginosa) |
PF00246(Peptidase_M14) | 4 | HIS A 118ASP A 210GLY A 211ASN A 206 | None | 1.36A | 5x7pB-4a39A:undetectable | 5x7pB-4a39A:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b6z | FAMILY M14UNASSIGNED PEPTIDASE (Burkholderiacenocepacia) |
PF00246(Peptidase_M14) | 4 | HIS A 119ASP A 218GLY A 219ASN A 214 | None | 1.32A | 5x7pB-4b6zA:2.9 | 5x7pB-4b6zA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | HIS A 25ASP A 217GLY A 190ASN A 20 | PO4 A 501 (-4.0A)NoneNonePO4 A 501 (-3.6A) | 1.10A | 5x7pB-4dhgA:undetectable | 5x7pB-4dhgA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdd | TRANSPORTIN-1 (Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 4 | HIS A 858ASP A 866GLY A 865ASN A 862 | None | 1.05A | 5x7pB-4fddA:undetectable | 5x7pB-4fddA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8t | GLUCARATEDEHYDRATASE (Actinobacillussuccinogenes) |
PF13378(MR_MLE_C) | 4 | HIS A 28ASP A 231GLY A 204ASN A 23 | SO4 A 501 (-4.2A) NA A 502 (-2.3A)NoneSO4 A 501 (-3.3A) | 1.10A | 5x7pB-4g8tA:undetectable | 5x7pB-4g8tA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqa | NAD BINDINGOXIDOREDUCTASE (Klebsiellapneumoniae) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | HIS A 87ASP A 190GLY A 189ASN A 84 | None | 1.19A | 5x7pB-4gqaA:undetectable | 5x7pB-4gqaA:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gyp | GLUCARATEDEHYDRATASE-RELATEDPROTEIN (Escherichiacoli) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | HIS C 31ASP C 234GLY C 207ASN C 26 | CIT C 501 (-3.9A)NoneNoneCIT C 501 (-3.3A) | 1.18A | 5x7pB-4gypC:undetectable | 5x7pB-4gypC:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hn8 | D-GLUCARATEDEHYDRATASE (Pseudomonasmendocina) |
PF13378(MR_MLE_C) | 4 | HIS A 34ASP A 252GLY A 225ASN A 29 | GOL A 502 (-4.3A)NoneNoneGOL A 502 (-3.5A) | 1.09A | 5x7pB-4hn8A:undetectable | 5x7pB-4hn8A:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyr | GLUCARATEDEHYDRATASE (Acidaminococcusintestini) |
PF13378(MR_MLE_C) | 4 | HIS A 27ASP A 231GLY A 204ASN A 22 | CL A 502 (-4.2A)NoneNoneNone | 1.13A | 5x7pB-4hyrA:undetectable | 5x7pB-4hyrA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oij | C-C MOTIF CHEMOKINE1 (Homo sapiens) |
PF00048(IL8) | 4 | HIS A 68ASP A 54GLY A 39ASN A 30 | SO4 A 105 ( 3.9A)NoneNoneSO4 A 105 (-3.6A) | 1.13A | 5x7pB-4oijA:undetectable | 5x7pB-4oijA:4.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p27 | VENOM ALLERGEN-LIKE(VAL) 4 PROTEIN (Schistosomamansoni) |
PF00188(CAP) | 4 | HIS A 15ASP A 144GLY A 75ASN A 77 | None | 1.43A | 5x7pB-4p27A:undetectable | 5x7pB-4p27A:7.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r27 | GLYCOSIDE HYDROLASE (Microbacteriumsp. Gsoil167) |
PF00232(Glyco_hydro_1) | 4 | HIS A 48ASP A 60TRP A 44GLY A 36 | None | 1.23A | 5x7pB-4r27A:2.5 | 5x7pB-4r27A:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcv | NADP-DEPENDENT2-HYDROXYACIDDEHYDROGENASE (Rhizobium etli) |
PF02826(2-Hacid_dh_C) | 4 | HIS A 113ASP A 121GLY A 119ASN A 276 | None | 1.29A | 5x7pB-4xcvA:undetectable | 5x7pB-4xcvA:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwt | DR2417 (Deinococcusradiodurans) |
PF00753(Lactamase_B)PF07521(RMMBL) | 4 | HIS A 86ASP A 209GLY A 174ASN A 158 | ZN A 601 (-3.1A)NoneNoneNone | 1.46A | 5x7pB-4xwtA:2.9 | 5x7pB-4xwtA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2v | HYDRAZINE SYNTHASEALPHA SUBUNIT (CandidatusKueneniastuttgartiensis) |
no annotation | 4 | HIS A 453ASP A 246GLY A 235ASN A 432 | None | 0.99A | 5x7pB-5c2vA:undetectable | 5x7pB-5c2vA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | ASP A 998TRP A1051GLY A1081ASN A1083 | GLC A1113 (-4.0A)GLC A1112 (-3.6A)GLC A1113 (-3.2A)GLC A1112 (-2.9A) | 0.91A | 5x7pB-5f7uA:22.7 | 5x7pB-5f7uA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | HIS A 985TRP A1051GLY A 996ASN A1083 | GLC A1112 (-3.9A)GLC A1112 (-3.6A)GLC A1112 (-3.6A)GLC A1112 (-2.9A) | 1.11A | 5x7pB-5f7uA:22.7 | 5x7pB-5f7uA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | HIS A 985TRP A1051GLY A1081ASN A1083 | GLC A1112 (-3.9A)GLC A1112 (-3.6A)GLC A1113 (-3.2A)GLC A1112 (-2.9A) | 0.51A | 5x7pB-5f7uA:22.7 | 5x7pB-5f7uA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fzp | DISPASEAUTOLYSIS-INDUCINGPROTEIN (Streptomycesmobaraensis) |
no annotation | 4 | HIS A 318ASP A 322GLY A 323ASN A 319 | None CA A1351 (-2.3A)NoneNone | 1.14A | 5x7pB-5fzpA:undetectable | 5x7pB-5fzpA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jb3 | 30S RIBOSOMALPROTEIN S6E (Pyrococcusabyssi) |
PF01092(Ribosomal_S6e) | 4 | HIS G 79ASP G 36GLY G 35ASN G 110 | C 21402 ( 3.5A)None C 21404 ( 3.7A) U 21403 ( 2.5A) | 1.25A | 5x7pB-5jb3G:undetectable | 5x7pB-5jb3G:6.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5moy | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 4 | ASP A1289TRP A1101GLY A1292ASN A1012 | None | 1.37A | 5x7pB-5moyA:6.4 | 5x7pB-5moyA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u04 | ZIKA VIRUS NS5 RDRP (Zika virus) |
PF00972(Flavi_NS5) | 4 | HIS A 714ASP A 846GLY A 842ASN A 716 | ZN A1001 (-3.2A)NoneNone ZN A1001 ( 4.6A) | 1.18A | 5x7pB-5u04A:undetectable | 5x7pB-5u04A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x32 | N-ACYLGLUCOSAMINE2-EPIMERASE (Marinomonasmediterranea) |
no annotation | 4 | ASP A 158TRP A 227GLY A 172ASN A 176 | None | 1.23A | 5x7pB-5x32A:undetectable | 5x7pB-5x32A:4.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 5 | HIS A 876ASP A 889TRP A 943GLY A 975ASN A 977 | None | 0.17A | 5x7pB-5x7sA:58.3 | 5x7pB-5x7sA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yap | SCYLLO-INOSITOLDEHYDROGENASE WITHL-GLUCOSEDEHYDROGENASEACTIVITY (Paracoccuslaeviglucosivorans) |
no annotation | 4 | HIS A 88ASP A 191GLY A 190ASN A 85 | NAI A 401 (-3.8A)8S0 A 402 (-4.3A)NoneNAI A 401 (-3.7A) | 1.23A | 5x7pB-5yapA:undetectable | 5x7pB-5yapA:5.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdz | THYMIDYLATE SYNTHASE (Escherichiacoli) |
no annotation | 4 | HIS A 212ASP A 20GLY A 25ASN A 211 | None | 1.34A | 5x7pB-6cdzA:undetectable | 5x7pB-6cdzA:4.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6day | DIHYDROPTEROATESYNTHASE (Xanthomonasalbilineans) |
no annotation | 4 | HIS A 263ASP A 101GLY A 63ASN A 27 | SO4 A 403 (-4.2A)NoneNoneSO4 A 403 (-3.1A) | 1.23A | 5x7pB-6dayA:2.1 | 5x7pB-6dayA:5.00 |