SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_B_ACRB1421_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 TYR A 702
GLU A 706
TYR A 713
GLY A 714
 None
 0.88A 5x7pB-1c4kA:
0.9		 5x7pB-1c4kA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 MET A  92
GLU A 113
GLY A 140
GLY A 139
 None
 0.65A 5x7pB-1dl2A:
undetectable		 5x7pB-1dl2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 MET A  92
GLU A 113
TYR A 159
GLY A 139
 None
 0.96A 5x7pB-1dl2A:
undetectable		 5x7pB-1dl2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 MET A 230
GLU A 335
TYR A 221
GLY A 222
 SAH  A 529 (-3.7A)
None
SAH  A 529 (-3.5A)
None
 0.96A 5x7pB-1f3lA:
0.1		 5x7pB-1f3lA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 MET A 313
TYR A 237
GLY A 245
GLY A 246
 None
3AT  A1000 (-4.7A)
None
3AT  A1000 (-3.0A)
 0.85A 5x7pB-1f5aA:
undetectable		 5x7pB-1f5aA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f97 JUNCTION ADHESION
MOLECULE

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 GLU A 120
TYR A 118
GLY A 115
GLY A 114
 None
 0.64A 5x7pB-1f97A:
undetectable		 5x7pB-1f97A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggv DIENELACTONE
HYDROLASE

(Pseudomonas
putida) 		PF01738
(DLH) 		4 GLU A  36
TYR A 145
GLY A 168
GLY A 169
 SEB  A 123 ( 4.2A)
SEB  A 123 ( 4.5A)
None
None
 0.75A 5x7pB-1ggvA:
undetectable		 5x7pB-1ggvA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		4 MET A  81
GLU A 170
GLY A  84
GLY A  85
 None
 0.97A 5x7pB-1iipA:
0.0		 5x7pB-1iipA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 TYR A 101
GLU A  78
TYR A 135
GLY A 131
GLY A 130
 None
 1.32A 5x7pB-1ixkA:
undetectable		 5x7pB-1ixkA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 MET A 269
TYR A 160
GLY A 176
GLY A  75
 None
 0.97A 5x7pB-1kcwA:
0.5		 5x7pB-1kcwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 GLU A  30
TYR A 237
GLY A 234
GLY A 231
 None
 0.66A 5x7pB-1khoA:
undetectable		 5x7pB-1khoA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpl HYPOTHETICAL 25.4
KDA PROTEIN F53F4.3
IN CHROMOSOME V

(Caenorhabditis
elegans) 		PF01302
(CAP_GLY) 		4 TYR A 184
TYR A 207
GLY A 208
GLY A 209
 None
 0.71A 5x7pB-1lplA:
undetectable		 5x7pB-1lplA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 MET A 391
GLU A 329
GLY A 348
GLY A 347
 None
 0.96A 5x7pB-1m54A:
1.8		 5x7pB-1m54A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbq JUNCTIONAL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 GLU A 121
TYR A 119
GLY A 116
GLY A 115
 None
 0.82A 5x7pB-1nbqA:
undetectable		 5x7pB-1nbqA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		4 GLU A 721
TYR A 723
GLY A 743
GLY A 742
 None
 0.91A 5x7pB-1nd7A:
undetectable		 5x7pB-1nd7A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 GLU A  30
TYR A 237
GLY A 234
GLY A 231
 None
 0.98A 5x7pB-1olpA:
undetectable		 5x7pB-1olpA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opg OPG2 FAB (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H 102
TYR H  32
GLY H  53
GLY H  54
 None
 0.77A 5x7pB-1opgH:
undetectable		 5x7pB-1opgH:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 TYR A 179
GLU A 172
GLY A 197
GLY A 196
 None
 0.88A 5x7pB-1px8A:
3.1		 5x7pB-1px8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx6 NPQTN SPECIFIC
SORTASE B

(Staphylococcus
aureus) 		PF04203
(Sortase) 		4 MET A  50
TYR A 165
GLU A 157
GLY A 163
 None
 0.86A 5x7pB-1qx6A:
undetectable		 5x7pB-1qx6A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		4 GLU A 246
TYR A 200
GLY A 225
GLY A 222
 GLN  A 400 ( 4.8A)
GLN  A 400 (-3.2A)
None
None
 0.74A 5x7pB-1sg9A:
undetectable		 5x7pB-1sg9A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		4 GLU A  29
TYR A  31
GLY A  33
GLY A  34
 None
 0.88A 5x7pB-1v19A:
3.0		 5x7pB-1v19A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 TYR A 193
GLU A 331
TYR A 194
GLY A 197
 None
 0.91A 5x7pB-1vclA:
undetectable		 5x7pB-1vclA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zt2 DNA PRIMASE LARGE
SUBUNIT

(Sulfolobus
solfataricus) 		PF04104
(DNA_primase_lrg) 		4 GLU B  62
TYR B  21
GLY B  22
GLY B  23
 None
 0.94A 5x7pB-1zt2B:
undetectable		 5x7pB-1zt2B:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		4 TYR A 148
GLU A 152
GLY A  96
GLY A  95
 None
ZN  A 501 (-2.0A)
None
None
 0.90A 5x7pB-2anpA:
1.0		 5x7pB-2anpA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4g DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF01180
(DHO_dh) 		4 TYR A 253
GLU A 256
GLY A 251
GLY A 223
 None
None
FMN  A1400 (-3.9A)
FMN  A1400 (-3.4A)
 0.86A 5x7pB-2b4gA:
2.8		 5x7pB-2b4gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		4 GLU A  22
TYR A   5
GLY A   6
GLY A   7
 None
 0.93A 5x7pB-2ch6A:
undetectable		 5x7pB-2ch6A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erx GTP-BINDING PROTEIN
DI-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A  36
GLU A  34
GLY A  17
GLY A  16
 PO4  A 402 ( 4.4A)
None
GDP  A 401 (-3.3A)
PO4  A 402 (-3.6A)
 0.91A 5x7pB-2erxA:
3.2		 5x7pB-2erxA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 GLU A 143
TYR A 212
GLY A 215
GLY A 115
 None
 0.97A 5x7pB-2gk3A:
undetectable		 5x7pB-2gk3A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A 650
TYR A 612
GLY A 611
GLY A 610
 None
 0.87A 5x7pB-2hdiA:
undetectable		 5x7pB-2hdiA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
None
None
ASP  A7001 ( 3.5A)
 0.92A 5x7pB-2himA:
2.9		 5x7pB-2himA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		4 GLU A 182
TYR A 135
GLY A 141
GLY A 140
 CA  A1398 ( 4.5A)
None
None
None
 0.95A 5x7pB-2jepA:
1.8		 5x7pB-2jepA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		4 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
None
None
ACT  A 601 ( 4.0A)
 0.90A 5x7pB-2ocdA:
undetectable		 5x7pB-2ocdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 MET A  77
GLU A  71
GLY A  35
GLY A  37
 None
 0.81A 5x7pB-2uu7A:
undetectable		 5x7pB-2uu7A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2k FERREDOXIN

(Mycolicibacterium
smegmatis) 		PF00037
(Fer4) 		4 TYR A  33
GLU A  38
TYR A  26
GLY A  28
 None
 0.88A 5x7pB-2v2kA:
undetectable		 5x7pB-2v2kA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLU A1450
TYR A1395
GLY A1377
GLY A1359
 None
 0.91A 5x7pB-2vdcA:
undetectable		 5x7pB-2vdcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 TYR A  64
GLU A 548
TYR A 551
GLY A 558
 None
 0.97A 5x7pB-2waeA:
undetectable		 5x7pB-2waeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus) 		PF06470
(SMC_hinge) 		4 TYR B 668
TYR B 667
GLY B 666
GLY B 665
 None
 0.75A 5x7pB-2wd5B:
undetectable		 5x7pB-2wd5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 GLU A  30
TYR A 237
GLY A 234
GLY A 231
 None
 0.91A 5x7pB-2wxuA:
undetectable		 5x7pB-2wxuA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 TYR A  38
GLU A  79
TYR A  24
GLY A  41
 None
 0.94A 5x7pB-2xn1A:
undetectable		 5x7pB-2xn1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqw COMPLEMENT C3

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 TYR A 268
TYR A 269
GLY A 270
GLY A 271
 None
 0.97A 5x7pB-2xqwA:
undetectable		 5x7pB-2xqwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLU A 317
TYR A 573
GLY A 572
GLY A 571
 None
 0.77A 5x7pB-2z1qA:
undetectable		 5x7pB-2z1qA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 GLU A 224
TYR A 396
GLY A 393
GLY A 392
 None
 0.85A 5x7pB-3a1iA:
undetectable		 5x7pB-3a1iA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		4 MET A 341
GLU A 306
GLY A 313
GLY A 317
 None
 0.87A 5x7pB-3b9nA:
undetectable		 5x7pB-3b9nA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3n DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF01180
(DHO_dh) 		4 TYR A 254
GLU A 257
GLY A 252
GLY A 224
 TYR  A 254 ( 1.3A)
GLU  A 257 ( 0.5A)
GLY  A 252 (-0.0A)
GLY  A 224 (-0.0A)
 0.94A 5x7pB-3c3nA:
undetectable		 5x7pB-3c3nA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 GLU A 389
TYR A 393
GLY A 370
GLY A 369
 None
 0.94A 5x7pB-3clqA:
undetectable		 5x7pB-3clqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE

(Methanoculleus
marisnigri) 		PF06314
(ADC) 		4 GLU A 106
TYR A  78
GLY A  76
GLY A  75
 None
 0.96A 5x7pB-3cmbA:
undetectable		 5x7pB-3cmbA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TYR A  95
GLU A  86
GLY A 576
GLY A 588
 None
 0.97A 5x7pB-3decA:
6.8		 5x7pB-3decA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR

(Bacillus
anthracis) 		PF12207
(DUF3600) 		4 MET A  82
TYR A  62
GLY A  63
GLY A  67
 None
 0.97A 5x7pB-3fh3A:
undetectable		 5x7pB-3fh3A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE

(Azospirillum
brasilense) 		PF00701
(DHDPS) 		4 MET A 152
GLU A 184
GLY A 225
GLY A  22
 KPI  A 182 ( 3.9A)
NA  A 409 ( 2.1A)
None
None
 0.92A 5x7pB-3fkrA:
undetectable		 5x7pB-3fkrA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		4 MET A 173
TYR A  78
GLY A  77
GLY A  76
 None
None
SO4  A 276 ( 4.6A)
None
 0.76A 5x7pB-3g23A:
undetectable		 5x7pB-3g23A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		4 MET A  67
TYR A  12
GLY A  42
GLY A  43
 None
None
None
GOL  A 154 ( 3.7A)
 0.62A 5x7pB-3grnA:
undetectable		 5x7pB-3grnA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens) 		PF03573
(OprD) 		4 GLU A 213
TYR A 176
GLY A 177
GLY A 178
 None
 0.95A 5x7pB-3jtyA:
undetectable		 5x7pB-3jtyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 TYR A1067
GLU A1021
TYR A1068
GLY A1069
 None
 0.90A 5x7pB-3l4kA:
undetectable		 5x7pB-3l4kA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhu DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
major) 		PF01180
(DHO_dh) 		4 TYR A 253
GLU A 256
GLY A 251
GLY A 223
 None
None
FMN  A 313 (-3.7A)
FMN  A 313 (-3.3A)
 0.89A 5x7pB-3mhuA:
undetectable		 5x7pB-3mhuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE

(Homo sapiens) 		PF05577
(Peptidase_S28) 		4 MET B 481
TYR B  89
GLY B 177
GLY B 178
 None
 0.75A 5x7pB-3n2zB:
undetectable		 5x7pB-3n2zB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		4 GLU B 459
TYR B 435
GLY B 436
GLY B 437
 None
 0.88A 5x7pB-3n6rB:
undetectable		 5x7pB-3n6rB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 TYR A 401
TYR A 332
GLY A 333
GLY A 334
 None
 0.97A 5x7pB-3nafA:
undetectable		 5x7pB-3nafA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndy ENDOGLUCANASE D

(Clostridium
cellulovorans) 		PF00150
(Cellulase) 		4 GLU A  89
TYR A 141
GLY A 142
GLY A   9
 None
 0.93A 5x7pB-3ndyA:
undetectable		 5x7pB-3ndyA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
 0.81A 5x7pB-3ntxA:
undetectable		 5x7pB-3ntxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A  76
GLU A  83
GLY A 235
GLY A 234
 None
 0.98A 5x7pB-3oytA:
undetectable		 5x7pB-3oytA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE

(Sphaerobacter
thermophilus) 		PF07228
(SpoIIE) 		4 MET A 213
GLU A 199
GLY A 167
GLY A 168
 None
 0.86A 5x7pB-3pu9A:
undetectable		 5x7pB-3pu9A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1n GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
paracasei) 		PF01263
(Aldose_epim) 		4 TYR A 237
GLU A 254
GLY A 258
GLY A 274
 None
EDO  A 302 (-2.9A)
None
None
 0.75A 5x7pB-3q1nA:
1.8		 5x7pB-3q1nA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u04 PEPTIDE DEFORMYLASE
1

(Ehrlichia
chaffeensis) 		PF01327
(Pep_deformylase) 		4 MET A  39
TYR A  90
GLY A  88
GLY A  87
 None
 0.95A 5x7pB-3u04A:
undetectable		 5x7pB-3u04A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 TYR A 244
GLU A 252
GLY A 413
GLY A 414
 None
 0.95A 5x7pB-3ue1A:
undetectable		 5x7pB-3ue1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1

(Actinomyces
oris) 		no annotation 4 GLU A 314
TYR A 427
GLY A 410
GLY A 411
 None
 0.84A 5x7pB-3uxfA:
undetectable		 5x7pB-3uxfA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 TYR A 230
GLU A 247
GLY A 227
GLY A 226
 ANP  A1401 ( 4.7A)
None
ANP  A1401 (-3.5A)
ANP  A1401 (-3.3A)
 0.92A 5x7pB-3zlbA:
undetectable		 5x7pB-3zlbA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 TYR A 324
GLU A 308
GLY A 292
GLY A 291
 None
 0.80A 5x7pB-4bq4A:
undetectable		 5x7pB-4bq4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1t INVASIN

(Yersinia
pseudotuberculosis) 		PF11924
(IAT_beta) 		4 TYR A 294
GLU A 297
GLY A 270
GLY A 271
 None
None
None
OLC  A 412 ( 4.0A)
 0.96A 5x7pB-4e1tA:
undetectable		 5x7pB-4e1tA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 GLU A 281
TYR A 208
GLY A 256
GLY A 255
 None
 0.90A 5x7pB-4e2zA:
undetectable		 5x7pB-4e2zA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 GLU A 392
TYR A 429
GLY A 430
GLY A 309
 ACT  A 811 (-3.9A)
EDO  A 824 ( 3.6A)
None
None
 0.88A 5x7pB-4fusA:
undetectable		 5x7pB-4fusA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		4 MET A  59
GLU A 316
TYR A  89
GLY A  90
 None
 0.94A 5x7pB-4g2tA:
undetectable		 5x7pB-4g2tA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kte GE148 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H 100
TYR H  33
GLY H  32
GLY H  31
 None
 0.90A 5x7pB-4kteH:
undetectable		 5x7pB-4kteH:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lab RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE B

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 TYR A  72
GLU A 231
GLY A 228
GLY A 227
 None
 0.83A 5x7pB-4labA:
undetectable		 5x7pB-4labA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 MET A 312
TYR A 236
GLY A 244
GLY A 245
 None
None
3AT  A 601 ( 4.7A)
3AT  A 601 ( 3.8A)
 0.93A 5x7pB-4lt6A:
undetectable		 5x7pB-4lt6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		4 GLU A 223
TYR A 210
GLY A 211
GLY A 212
 None
 0.98A 5x7pB-4m5pA:
undetectable		 5x7pB-4m5pA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A 405
TYR A 404
GLY A 403
GLY A 402
 None
 0.71A 5x7pB-4mmoA:
undetectable		 5x7pB-4mmoA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n81 INOSITOL
MONOPHOSPHATASE

(Zymomonas
mobilis) 		PF00459
(Inositol_P) 		4 GLU A 125
TYR A 188
GLY A 185
GLY A 184
 None
 0.85A 5x7pB-4n81A:
undetectable		 5x7pB-4n81A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozv ALGINATE LYASE

(Pseudomonas
aeruginosa) 		PF05426
(Alginate_lyase) 		5 MET A 122
GLU A 177
TYR A 155
GLY A 153
GLY A 354
 None
 1.44A 5x7pB-4ozvA:
undetectable		 5x7pB-4ozvA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		4 TYR A 118
GLU A 122
TYR A 115
GLY A 117
 None
 0.97A 5x7pB-4pxqA:
undetectable		 5x7pB-4pxqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 MET A 541
TYR A 727
GLU A 722
GLY A 623
 None
 0.87A 5x7pB-4q1vA:
undetectable		 5x7pB-4q1vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 GLU A 283
TYR A 209
GLY A 257
GLY A 256
 None
 0.89A 5x7pB-4rvhA:
undetectable		 5x7pB-4rvhA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 TYR A 250
GLU A 296
TYR A 251
GLY A 252
 None
CAC  A1574 ( 4.8A)
CAC  A1574 ( 4.1A)
None
 0.96A 5x7pB-4v2xA:
1.9		 5x7pB-4v2xA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzh DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
braziliensis) 		PF01180
(DHO_dh) 		4 TYR A 253
GLU A 256
GLY A 251
GLY A 223
 None
None
FMN  A 401 (-3.5A)
FMN  A 401 (-3.3A)
 0.79A 5x7pB-4wzhA:
undetectable		 5x7pB-4wzhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 TYR A 225
GLU A 271
TYR A 226
GLY A 227
 None
 0.95A 5x7pB-5e0cA:
undetectable		 5x7pB-5e0cA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 TYR A 266
GLU A 172
GLY A 288
GLY A 287
 HIS  A 502 (-4.7A)
None
None
HIS  A 502 ( 3.8A)
 0.96A 5x7pB-5e3iA:
undetectable		 5x7pB-5e3iA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 MET A 394
GLU A 378
GLY A 201
GLY A 410
 None
MG  A 503 (-3.8A)
None
None
 0.91A 5x7pB-5e4rA:
undetectable		 5x7pB-5e4rA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 337
TYR A 348
GLY A 347
GLY A 346
 None
 0.97A 5x7pB-5e76A:
undetectable		 5x7pB-5e76A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		4 MET A 125
GLU A  38
GLY A 100
GLY A  99
 None
 0.81A 5x7pB-5gxfA:
undetectable		 5x7pB-5gxfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PUTATIVE U3 SNORNP
PROTEIN

(Chaetomium
thermophilum) 		PF04192
(Utp21) 		4 TYR C 937
GLU C 942
GLY C 931
GLY C 932
 None
 0.89A 5x7pB-5icaC:
undetectable		 5x7pB-5icaC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 GLU A 442
TYR A 418
GLY A 419
GLY A 420
 None
 0.98A 5x7pB-5infA:
undetectable		 5x7pB-5infA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 TYR A 533
TYR A 532
GLY A 549
GLY A 450
 None
 0.91A 5x7pB-5k8dA:
undetectable		 5x7pB-5k8dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 4 MET A 466
GLU A 676
TYR A 432
GLY A 431
 None
U  C   2 ( 4.4A)
U  C   2 ( 3.5A)
U  C   3 ( 3.5A)
 0.81A 5x7pB-5n94A:
undetectable		 5x7pB-5n94A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 MET A 302
TYR A 367
GLY A 466
GLY A 255
 None
 0.98A 5x7pB-5njfA:
undetectable		 5x7pB-5njfA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 GLU A 281
TYR A 208
GLY A 256
GLY A 255
 None
 0.90A 5x7pB-5t67A:
undetectable		 5x7pB-5t67A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tii 3-OXOACYL-ACP
REDUCTASE

(uncultured
bacterium) 		PF13561
(adh_short_C2) 		4 GLU A  43
TYR A  40
GLY A  17
GLY A  22
 None
 0.95A 5x7pB-5tiiA:
undetectable		 5x7pB-5tiiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		4 GLU A 127
TYR A 117
GLY A 153
GLY A 152
 None
None
HSX  A 302 (-3.9A)
HSX  A 302 (-3.5A)
 0.94A 5x7pB-5vn4A:
undetectable		 5x7pB-5vn4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7l N,N'-DIACETYLBACILLI
OSAMINYL-1-PHOSPHATE
TRANSFERASE

(Campylobacter
concisus) 		no annotation 4 MET A  57
GLU A  94
GLY A 135
GLY A 110
 None
PO4  A 302 ( 3.3A)
None
None
 0.86A 5x7pB-5w7lA:
undetectable		 5x7pB-5w7lA:
5.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 TYR A 218
GLU A 228
TYR A 230
GLY A 232
GLY A 233
 None
 0.16A 5x7pB-5x7sA:
58.3		 5x7pB-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 4 MET A 126
TYR A 161
TYR A 162
GLY A 163
 None
 0.91A 5x7pB-6b5vA:
undetectable		 5x7pB-6b5vA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 TYR L 312
GLU L 305
TYR L 303
GLY L 302
GLY L 301
 None
 1.30A 5x7pB-6ehsL:
undetectable		 5x7pB-6ehsL:
5.91