SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_A_ACRA1471

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 172
GLU A 269
HIS A 236
THR A 272
HIS A 229
 ZN  A 500 ( 4.6A)
ZN  A 500 (-1.8A)
None
ZN  A 500 ( 4.8A)
ZN  A 500 (-3.1A)
 1.31A 5x7pA-2fpqA:
0.0		 5x7pA-2fpqA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 ASP A 250
LEU A  95
ARG A 169
ASN A 128
THR A 130
 UNL  A   1 ( 2.9A)
UNL  A   1 ( 4.5A)
UNL  A   1 ( 2.8A)
None
None
 1.30A 5x7pA-3l49A:
0.0		 5x7pA-3l49A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		5 ARG A 309
ARG A 215
ASN A 135
THR A 100
HIS A 116
 ACT  A 505 (-4.1A)
UDP  A 501 (-3.1A)
None
None
None
 1.41A 5x7pA-5dldA:
0.1		 5x7pA-5dldA:
16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		12 ARG A 362
ARG A 368
TYR A 373
ASP A1160
LEU A1165
GLU A1169
ARG A1177
TYR A1179
HIS A1181
ASN A1213
THR A1269
HIS A1271
 None
None
MES  A1707 (-3.6A)
None
None
None
None
None
None
MES  A1707 (-3.4A)
None
None
 0.39A 5x7pA-5x7sA:
59.0		 5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		6 ARG A 362
ASP A1160
LEU A1165
GLU A1169
ARG A1177
HIS A1271
 None
 1.05A 5x7pA-5x7sA:
59.0		 5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		7 TYR A 372
LEU A1165
GLU A1169
ARG A1177
HIS A1181
THR A1269
HIS A1271
 None
 1.35A 5x7pA-5x7sA:
59.0		 5x7pA-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 5 ARG A  84
ASP A 374
LEU A  73
HIS A 313
THR A 318
 None
 1.39A 5x7pA-5y0qA:
1.0		 5x7pA-5y0qA:
undetectable