SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_A_ACRA1431_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE


(Trypanosoma
brucei)
PF00162
(PGK)
4 ASN A  26
HIS A  62
GLY A  68
ASN A 133
3PG  A 423 (-3.9A)
3PG  A 423 (-4.1A)
None
None
1.11A 5x7pA-13pkA:
undetectable
5x7pA-13pkA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE


(Bos taurus)
PF00135
(COesterase)
4 HIS A 435
ASP A 438
GLY A 315
ASN A 317
None
1.12A 5x7pA-1aqlA:
0.1
5x7pA-1aqlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 HIS A  38
ASP A 241
GLY A 214
ASN A  33
None
0.94A 5x7pA-1bqgA:
undetectable
5x7pA-1bqgA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 ASP A 196
ASP A 357
GLY A 358
ASN A 370
ZN  A 501 (-2.1A)
None
None
None
0.95A 5x7pA-1fnoA:
0.0
5x7pA-1fnoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03372
(Exo_endo_phos)
4 ASN A 742
HIS A 699
GLY A 569
ASN A 566
None
None
None
CA  A 301 ( 4.6A)
1.13A 5x7pA-1i9zA:
undetectable
5x7pA-1i9zA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus)
PF14592
(Chondroitinas_B)
4 ASN A 358
HIS A 356
ASP A 401
GLY A 422
None
0.93A 5x7pA-1ofmA:
0.0
5x7pA-1ofmA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osm OMPK36

(Klebsiella
pneumoniae)
PF00267
(Porin_1)
4 ASN A 163
ASP A 172
GLY A 173
ASN A 170
None
0.87A 5x7pA-1osmA:
undetectable
5x7pA-1osmA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE


(Bacillus
intermedius)
PF00089
(Trypsin)
5 ASN A 196
HIS A 186
ASP A 135
GLY A 134
ASN A 170
None
1.36A 5x7pA-1p3cA:
undetectable
5x7pA-1p3cA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)


(Escherichia
coli)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ASP A 183
ASP A 155
GLY A 156
ASN A  64
None
CA  A 675 (-3.3A)
TPP  A 670 ( 3.5A)
None
1.06A 5x7pA-1qgdA:
0.0
5x7pA-1qgdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Archaeoglobus
fulgidus)
PF01513
(NAD_kinase)
4 ASN A 234
HIS A  78
ASP A  49
GLY A  48
None
None
NAP  A3075 (-4.2A)
NAP  A3075 (-3.4A)
1.08A 5x7pA-1suwA:
undetectable
5x7pA-1suwA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans)
PF13277
(YmdB)
4 ASN A  65
HIS A  66
GLY A 205
ASN A  38
None
1.14A 5x7pA-1t70A:
2.1
5x7pA-1t70A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans)
PF13277
(YmdB)
4 HIS A  66
ASP A   8
GLY A 205
ASN A  38
None
0.94A 5x7pA-1t70A:
2.1
5x7pA-1t70A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae)
PF13277
(YmdB)
4 ASN A  71
HIS A  72
GLY A 216
ASN A  44
FE  A 302 (-2.8A)
None
None
FE  A 301 (-2.7A)
0.62A 5x7pA-1t71A:
undetectable
5x7pA-1t71A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae)
PF13277
(YmdB)
4 HIS A  72
ASP A  12
GLY A 216
ASN A  44
None
FE  A 301 (-3.2A)
None
FE  A 301 (-2.7A)
1.03A 5x7pA-1t71A:
undetectable
5x7pA-1t71A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Archaeoglobus
fulgidus)
PF01513
(NAD_kinase)
4 ASN A 234
HIS A  78
ASP A  49
GLY A  48
None
None
NAP  A3076 (-4.2A)
NAP  A3076 ( 3.7A)
1.10A 5x7pA-1z0uA:
undetectable
5x7pA-1z0uA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyl HYPOTHETICAL PROTEIN
YIHE


(Escherichia
coli)
PF01636
(APH)
4 ASN A  39
ASP A 217
ASP A 201
GLY A 200
None
1.06A 5x7pA-1zylA:
undetectable
5x7pA-1zylA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ASN A 119
HIS A 303
ASP A 136
ASN A 137
None
1.04A 5x7pA-2a8xA:
2.1
5x7pA-2a8xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904


(Enterococcus
faecalis)
PF12706
(Lactamase_B_2)
4 HIS A 195
ASP A 168
GLY A 260
ASN A 264
None
1.15A 5x7pA-2az4A:
undetectable
5x7pA-2az4A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF03971
(IDH)
4 ASN A 177
ASP A 450
ASP A 428
GLY A 429
None
1.11A 5x7pA-2b0tA:
undetectable
5x7pA-2b0tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x ANTIBODY AQC2 FAB

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 ASN L  30
HIS L  31
ASP H 101
GLY H 102
None
None
MG  A 400 (-3.6A)
None
1.03A 5x7pA-2b2xL:
undetectable
5x7pA-2b2xL:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwa SINGLE-STRAND
BINDING PROTEIN


(Thermus
thermophilus)
PF00436
(SSB)
4 HIS A 171
ASP A 102
GLY A  80
ASN A   6
None
0.97A 5x7pA-2cwaA:
undetectable
5x7pA-2cwaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1)
PF02225
(PA)
PF04389
(Peptidase_M28)
4 ASN A 274
ASP A 230
ASP A 240
GLY A 237
None
None
ZN  A1001 ( 2.4A)
None
1.11A 5x7pA-2ek8A:
undetectable
5x7pA-2ek8A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C


(Escherichia
coli)
PF00267
(Porin_1)
4 ASN A 168
ASP A 178
GLY A 179
ASN A 176
None
0.86A 5x7pA-2j1nA:
undetectable
5x7pA-2j1nA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 246
ASP A 224
GLY A 171
ASN A 199
None
1.06A 5x7pA-2oqhA:
3.2
5x7pA-2oqhA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC


(Mus musculus)
PF00162
(PGK)
4 ASN A  25
ASP A  67
GLY A  68
ASN A 120
None
1.01A 5x7pA-2paaA:
undetectable
5x7pA-2paaA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE


(Phaseolus
vulgaris)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
4 ASN A 201
HIS A 202
ASP A 135
GLY A 366
ZN  A 434 ( 2.7A)
SO4  A 435 (-4.2A)
FE  A 433 ( 2.9A)
None
1.00A 5x7pA-2qfrA:
undetectable
5x7pA-2qfrA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbd BH2358 PROTEIN

(Bacillus
halodurans)
PF11553
(DUF3231)
4 ASN A 153
ASP A  46
TRP A 156
GLY A  43
None
1.14A 5x7pA-2rbdA:
undetectable
5x7pA-2rbdA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE
SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1


(Archaeoglobus
fulgidus;
Oryctolagus
cuniculus)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
4 ASP I 654
ASP I 653
GLY I 636
ASN H 330
None
1.05A 5x7pA-2voyI:
undetectable
5x7pA-2voyI:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzp EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF16990
(CBM_35)
4 ASN A  21
HIS A  22
GLY A 119
ASN A 121
None
None
None
EDO  A1130 (-3.4A)
1.03A 5x7pA-2vzpA:
8.7
5x7pA-2vzpA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzp EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF16990
(CBM_35)
4 ASN A  21
HIS A  22
TRP A  90
ASN A 121
None
None
None
EDO  A1130 (-3.4A)
0.33A 5x7pA-2vzpA:
8.7
5x7pA-2vzpA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w87 ESTERASE D

(Cellvibrio
japonicus)
PF03422
(CBM_6)
4 ASN A  29
HIS A  30
TRP A  99
ASN A 130
GCU  A1150 ( 4.7A)
GCU  A1150 (-4.0A)
GCU  A1150 (-3.9A)
GCU  A1150 (-3.1A)
0.21A 5x7pA-2w87A:
6.7
5x7pA-2w87A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C


(Escherichia
coli)
PF00267
(Porin_1)
4 ASN A 164
ASP A 175
GLY A 176
ASN A 173
None
0.85A 5x7pA-2xe5A:
undetectable
5x7pA-2xe5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625


(Thermus
thermophilus)
PF13277
(YmdB)
4 ASN A  65
HIS A  66
GLY A 202
ASN A  38
CO  A 253 (-2.5A)
None
None
None
0.73A 5x7pA-2z06A:
undetectable
5x7pA-2z06A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajz ANCESTRAL CONGERIN
CON-ANC


(-)
PF00337
(Gal-bind_lectin)
4 ASN A  31
HIS A  42
ASP A  64
GLY A  65
None
GAL  A 133 (-4.0A)
None
None
1.07A 5x7pA-3ajzA:
undetectable
5x7pA-3ajzA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri)
PF00128
(Alpha-amylase)
4 ASN A 446
HIS A 518
ASP A 137
GLY A 138
None
None
TRS  A6646 (-3.0A)
TRS  A6646 ( 4.8A)
1.12A 5x7pA-3czeA:
undetectable
5x7pA-3czeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA


(Bacillus
subtilis)
PF01510
(Amidase_2)
4 HIS A  43
ASP A  39
ASP A  99
GLY A 100
None
0.99A 5x7pA-3hmbA:
undetectable
5x7pA-3hmbA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis)
PF00704
(Glyco_hydro_18)
4 ASN A 225
ASP A 158
GLY A 156
ASN A  81
None
1.12A 5x7pA-3ianA:
undetectable
5x7pA-3ianA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 ASP A 199
ASP A 359
GLY A 360
ASN A 372
ZN  A 411 (-1.9A)
None
None
None
1.01A 5x7pA-3ifeA:
undetectable
5x7pA-3ifeA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ASP A 185
ASP A 157
GLY A 158
ASN A  66
None
None
OCS  A 159 ( 2.4A)
None
1.05A 5x7pA-3komA:
undetectable
5x7pA-3komA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF13378
(MR_MLE_C)
4 HIS A  27
ASP A 231
GLY A 204
ASN A  22
SO4  A 450 (-4.1A)
None
None
SO4  A 450 (-3.2A)
1.12A 5x7pA-3mznA:
undetectable
5x7pA-3mznA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 ASN A 449
HIS A 400
GLY A 276
ASN A 273
None
None
None
MG  A  61 ( 4.8A)
1.10A 5x7pA-3n9vA:
undetectable
5x7pA-3n9vA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
no annotation 4 ASN B 432
HIS B 718
GLY B 565
ASN B 609
None
0.97A 5x7pA-3nr8B:
undetectable
5x7pA-3nr8B:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE


(Enterobacter
cloacae)
PF00328
(His_Phos_2)
4 ASN A  25
ASP A 209
ASP A 288
ASN A 205
IHP  A 550 ( 4.4A)
IHP  A 550 (-3.6A)
IHP  A 550 (-2.4A)
IHP  A 550 ( 4.2A)
1.11A 5x7pA-3ntlA:
undetectable
5x7pA-3ntlA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE


(Burkholderia
lata)
PF13378
(MR_MLE_C)
4 ASN A 309
ASP A 281
GLY A 228
ASN A 257
MG  A 476 (-2.4A)
None
None
MG  A 476 ( 4.3A)
1.13A 5x7pA-3nxlA:
undetectable
5x7pA-3nxlA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE


(Burkholderia
lata)
PF13378
(MR_MLE_C)
4 HIS A  36
ASP A 255
GLY A 228
ASN A  31
CO3  A 477 (-4.0A)
MG  A 476 (-2.8A)
None
CO3  A 477 ( 3.8A)
1.12A 5x7pA-3nxlA:
undetectable
5x7pA-3nxlA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE


(Plasmodium
falciparum)
PF00162
(PGK)
4 ASN A  26
HIS A  63
GLY A  69
ASN A 120
SO4  A 601 ( 4.5A)
SO4  A 601 (-4.4A)
None
None
1.13A 5x7pA-3oz7A:
undetectable
5x7pA-3oz7A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Ralstonia
pickettii)
PF13378
(MR_MLE_C)
4 HIS A  32
ASP A 251
GLY A 224
ASN A  27
GKR  A 472 (-3.9A)
MG  A 471 ( 2.6A)
None
GKR  A 472 (-3.5A)
1.12A 5x7pA-3p0wA:
undetectable
5x7pA-3p0wA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE


(Tenebrio
molitor)
PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29)
4 ASP A 249
ASP A 234
GLY A 302
ASN A 300
None
0.89A 5x7pA-3qt4A:
undetectable
5x7pA-3qt4A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens)
PF01501
(Glyco_transf_8)
4 ASN A 188
HIS A 212
ASP A 163
GLY A 162
None
MN  A 263 ( 3.3A)
None
None
1.07A 5x7pA-3rmvA:
undetectable
5x7pA-3rmvA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7


(Sphingopyxis
macrogoltabida)
PF00067
(p450)
5 ASN A 402
HIS A 304
ASP A  85
ASP A  86
GLY A  80
None
1.33A 5x7pA-3rwlA:
undetectable
5x7pA-3rwlA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB


(Bacillus
anthracis)
PF04183
(IucA_IucC)
PF06276
(FhuF)
4 ASN A 355
ASP A 262
GLY A 264
ASN A 197
None
EDO  A 618 (-4.3A)
EDO  A 618 ( 4.1A)
None
1.15A 5x7pA-3to3A:
undetectable
5x7pA-3to3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ASP A 203
ASP A 175
GLY A 176
ASN A  84
None
None
OCS  A 177 ( 2.4A)
OCS  A 177 ( 4.2A)
1.04A 5x7pA-3uk1A:
undetectable
5x7pA-3uk1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum)
PF13378
(MR_MLE_C)
4 HIS A  29
ASP A 220
GLY A 193
ASN A  24
SO4  A 424 (-3.8A)
MG  A 425 ( 2.4A)
None
SO4  A 424 (-3.8A)
1.12A 5x7pA-3va8A:
undetectable
5x7pA-3va8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE


(Mycolicibacterium
smegmatis)
PF13378
(MR_MLE_C)
4 HIS A  30
ASP A 222
GLY A 195
ASN A  25
ACT  A 504 (-4.0A)
NA  A 502 (-2.9A)
None
ACT  A 504 (-3.9A)
1.11A 5x7pA-3vdgA:
undetectable
5x7pA-3vdgA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7


(Arabidopsis
thaliana)
no annotation 4 ASP D  40
ASP D  39
GLY D  37
ASN D  97
None
1.07A 5x7pA-3vx8D:
undetectable
5x7pA-3vx8D:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE


(Bacillus
circulans)
PF13199
(Glyco_hydro_66)
PF16990
(CBM_35)
5 ASN A 438
HIS A 439
ASP A 449
TRP A 506
ASN A 539
None
0.32A 5x7pA-3wnpA:
9.2
5x7pA-3wnpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyp CIP1

(Trichoderma
reesei)
no annotation 4 ASP A 174
ASP A 121
GLY A 126
ASN A 171
None
1.12A 5x7pA-3zypA:
7.1
5x7pA-3zypA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE


(Bacillus
subtilis)
PF13277
(YmdB)
4 ASN A  67
HIS A  68
GLY A 207
ASN A  40
PO4  A1265 ( 2.6A)
PO4  A1265 (-3.7A)
None
FE2  A1266 ( 2.5A)
0.70A 5x7pA-4b2oA:
2.3
5x7pA-4b2oA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE


(Bacillus
subtilis)
PF13277
(YmdB)
4 HIS A  68
ASP A   8
GLY A 207
ASN A  40
PO4  A1265 (-3.7A)
FE2  A1266 (-3.1A)
None
FE2  A1266 ( 2.5A)
0.96A 5x7pA-4b2oA:
2.3
5x7pA-4b2oA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ASP A 184
ASP A 129
TRP A 302
GLY A 276
None
0.80A 5x7pA-4bgvA:
undetectable
5x7pA-4bgvA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Thermobispora
bispora)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 HIS A  25
ASP A 217
GLY A 190
ASN A  20
PO4  A 501 (-4.0A)
None
None
PO4  A 501 (-3.6A)
1.11A 5x7pA-4dhgA:
undetectable
5x7pA-4dhgA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
4 HIS A 858
ASP A 866
GLY A 865
ASN A 862
None
1.01A 5x7pA-4fddA:
undetectable
5x7pA-4fddA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica)
PF00871
(Acetate_kinase)
4 ASP A 196
ASP A 319
GLY A 198
ASN A 215
None
1.14A 5x7pA-4fwmA:
undetectable
5x7pA-4fwmA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE


(Actinobacillus
succinogenes)
PF13378
(MR_MLE_C)
4 HIS A  28
ASP A 231
GLY A 204
ASN A  23
SO4  A 501 (-4.2A)
NA  A 502 (-2.3A)
None
SO4  A 501 (-3.3A)
1.12A 5x7pA-4g8tA:
undetectable
5x7pA-4g8tA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata)
PF00840
(Glyco_hydro_7)
4 ASN A 218
ASP A 426
GLY A 160
ASN A 398
None
1.10A 5x7pA-4haqA:
4.8
5x7pA-4haqA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION


(synthetic
construct)
PF01731
(Arylesterase)
4 ASN A 168
ASP A 269
GLY A 344
ASN A 270
CA  A 402 ( 3.8A)
CA  A 402 (-2.6A)
None
CA  A 402 ( 3.8A)
1.09A 5x7pA-4hhqA:
undetectable
5x7pA-4hhqA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE


(Pseudomonas
mendocina)
PF13378
(MR_MLE_C)
4 HIS A  34
ASP A 252
GLY A 225
ASN A  29
GOL  A 502 (-4.3A)
None
None
GOL  A 502 (-3.5A)
1.10A 5x7pA-4hn8A:
undetectable
5x7pA-4hn8A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE


(Acidaminococcus
intestini)
PF13378
(MR_MLE_C)
4 HIS A  27
ASP A 231
GLY A 204
ASN A  22
CL  A 502 (-4.2A)
None
None
None
1.14A 5x7pA-4hyrA:
undetectable
5x7pA-4hyrA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE


(Escherichia
coli)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ASN A 123
HIS A 307
ASP A 139
ASN A 140
SO4  A 502 (-4.9A)
None
None
None
1.07A 5x7pA-4jq9A:
undetectable
5x7pA-4jq9A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 ASN A 348
HIS A 349
ASP A 422
GLY A 431
GOL  A 705 (-2.9A)
GOL  A 705 (-4.4A)
None
None
1.09A 5x7pA-4lxfA:
2.6
5x7pA-4lxfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE


(Methylacidiphilum
fumariolicum)
PF13360
(PQQ_2)
4 ASN A 406
ASP A 388
ASP A 301
GLY A 302
None
PQQ  A 602 (-2.7A)
CE  A 601 ( 2.3A)
None
1.13A 5x7pA-4maeA:
undetectable
5x7pA-4maeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
PF16403
(DUF5011)
4 ASN A 216
ASP A 149
GLY A 147
ASN A  67
None
1.13A 5x7pA-4mb5A:
3.9
5x7pA-4mb5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN


(Thermomonospora
curvata)
PF13458
(Peripla_BP_6)
4 ASN A 273
ASP A 169
ASP A 167
GLY A 205
PLM  A 601 ( 3.8A)
None
None
None
1.01A 5x7pA-4n03A:
undetectable
5x7pA-4n03A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C


(Butyrivibrio
proteoclasticus)
PF00150
(Cellulase)
4 ASN A 378
ASP A 356
GLY A  53
ASN A  77
None
1.11A 5x7pA-4nf7A:
undetectable
5x7pA-4nf7A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oij C-C MOTIF CHEMOKINE
1


(Homo sapiens)
PF00048
(IL8)
4 HIS A  68
ASP A  54
GLY A  39
ASN A  30
SO4  A 105 ( 3.9A)
None
None
SO4  A 105 (-3.6A)
1.13A 5x7pA-4oijA:
undetectable
5x7pA-4oijA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Ochrobactrum
anthropi)
PF01547
(SBP_bac_1)
4 ASN A 144
HIS A 146
TRP A 272
ASN A 303
None
GLC  A 501 (-4.4A)
GLC  A 501 (-3.5A)
GLC  A 501 (-3.9A)
1.13A 5x7pA-4r2bA:
undetectable
5x7pA-4r2bA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis)
PF11477
(PM0188)
4 ASN A  58
HIS A   7
GLY A 115
ASN A  82
None
1.03A 5x7pA-4v39A:
undetectable
5x7pA-4v39A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
4 ASN A 216
ASP A 149
GLY A 147
ASN A  67
None
1.12A 5x7pA-4w5zA:
undetectable
5x7pA-4w5zA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa0 POSSIBLE ADHESIN

(Caldicellulosiruptor
kronotskyensis)
no annotation 4 ASN A 562
ASP A 295
GLY A 275
ASN A 257
None
1.02A 5x7pA-4wa0A:
undetectable
5x7pA-4wa0A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ASP A 183
ASP A 155
GLY A 156
ASN A  64
None
1.05A 5x7pA-4xeuA:
undetectable
5x7pA-4xeuA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis)
no annotation 5 ASN A 488
HIS A 489
ASP A 499
TRP A 566
ASN A 598
GLC  A 704 ( 4.4A)
GLC  A 704 (-3.9A)
None
GLC  A 704 (-3.6A)
GLC  A 704 (-3.0A)
0.17A 5x7pA-5awpA:
7.4
5x7pA-5awpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT


(Candidatus
Kuenenia
stuttgartiensis)
no annotation 4 HIS A 453
ASP A 246
GLY A 235
ASN A 432
None
0.96A 5x7pA-5c2vA:
undetectable
5x7pA-5c2vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d62 AGGLUTININ

(Marasmius
oreades)
PF14200
(RicinB_lectin_2)
4 ASN A  95
HIS A  97
ASP A  28
GLY A  29
GLA  A 305 (-3.3A)
GLA  A 305 (-3.9A)
GLA  A 306 ( 4.9A)
None
0.85A 5x7pA-5d62A:
undetectable
5x7pA-5d62A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE


(Staphylococcus
aureus)
no annotation 4 ASN B  11
ASP B  97
GLY B   7
ASN B  56
5RX  B 202 (-3.8A)
MG  B 204 (-2.5A)
None
5RX  B 202 (-3.2A)
1.06A 5x7pA-5etsB:
undetectable
5x7pA-5etsB:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 ASP A 998
TRP A1051
GLY A1081
ASN A1083
GLC  A1113 (-4.0A)
GLC  A1112 (-3.6A)
GLC  A1113 (-3.2A)
GLC  A1112 (-2.9A)
0.93A 5x7pA-5f7uA:
20.9
5x7pA-5f7uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 HIS A 985
TRP A1051
GLY A 996
ASN A1083
GLC  A1112 (-3.9A)
GLC  A1112 (-3.6A)
GLC  A1112 (-3.6A)
GLC  A1112 (-2.9A)
1.12A 5x7pA-5f7uA:
20.9
5x7pA-5f7uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
4 HIS A 985
TRP A1051
GLY A1081
ASN A1083
GLC  A1112 (-3.9A)
GLC  A1112 (-3.6A)
GLC  A1113 (-3.2A)
GLC  A1112 (-2.9A)
0.52A 5x7pA-5f7uA:
20.9
5x7pA-5f7uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvn OMPC PORIN

(Enterobacter
cloacae)
PF00267
(Porin_1)
4 ASN A 164
ASP A 174
GLY A 175
ASN A 172
None
L1L  A 414 ( 2.9A)
None
None
0.82A 5x7pA-5fvnA:
undetectable
5x7pA-5fvnA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum)
no annotation 4 ASP A 411
ASP A 341
GLY A 340
ASN A 409
NAG  A 704 (-3.5A)
NAG  A 704 ( 4.2A)
None
None
1.05A 5x7pA-5gqfA:
undetectable
5x7pA-5gqfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ASP A 183
ASP A 155
GLY A 156
ASN A  64
None
CA  A 703 ( 3.2A)
TPP  A 701 (-3.5A)
None
1.09A 5x7pA-5i51A:
undetectable
5x7pA-5i51A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u04 ZIKA VIRUS NS5 RDRP

(Zika virus)
PF00972
(Flavi_NS5)
4 HIS A 714
ASP A 846
GLY A 842
ASN A 716
ZN  A1001 (-3.2A)
None
None
ZN  A1001 ( 4.6A)
1.14A 5x7pA-5u04A:
undetectable
5x7pA-5u04A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42


(Saccharomyces
cerevisiae)
no annotation 4 ASN D  19
ASP G 262
ASP G 258
GLY G 259
None
1.13A 5x7pA-5uz5D:
undetectable
5x7pA-5uz5D:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE


(Paenibacillus
sp. 598K)
PF13199
(Glyco_hydro_66)
PF16990
(CBM_35)
5 ASN A 439
HIS A 440
ASP A 450
TRP A 507
ASN A 540
GLC  A 811 ( 4.7A)
GLC  A 811 ( 3.7A)
None
GLC  A 811 ( 3.9A)
GLC  A 811 ( 2.8A)
0.28A 5x7pA-5x7hA:
3.9
5x7pA-5x7hA:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE


(Paenibacillus
sp. 598K)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110)
7 ASN A 875
HIS A 876
ASP A 886
ASP A 889
TRP A 943
GLY A 975
ASN A 977
None
0.17A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE


(Paenibacillus
sp. 598K)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110)
4 ASP A 491
ASP A 529
GLY A 532
ASN A 534
None
1.12A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE


(Paenibacillus
sp. 598K)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110)
4 HIS A1009
ASP A1019
TRP A1077
ASN A1109
None
0.27A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11


(Toxoplasma
gondii)
PF00411
(Ribosomal_S11)
PF01015
(Ribosomal_S3Ae)
4 ASN B  95
ASP O  28
GLY O  29
ASN B  42
None
0.92A 5x7pA-5xxuB:
undetectable
5x7pA-5xxuB:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB


(Rattus
norvegicus)
no annotation 4 ASN P 187
ASP P 171
GLY P 183
ASN P 369
None
1.02A 5x7pA-6c1dP:
undetectable
5x7pA-6c1dP:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft

()
no annotation 4 ASN B 271
HIS B 267
ASP A 328
GLY A 163
None
None
NAD  A 502 (-3.6A)
NAD  A 502 (-3.5A)
1.02A 5x7pA-6dftB:
undetectable
5x7pA-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
no annotation 4 ASN A 656
ASP A 710
ASP A 714
GLY A 715
None
0.97A 5x7pA-6f91A:
6.1
5x7pA-6f91A:
5.33