SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_A_ACRA1431_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 13pk | 3-PHOSPHOGLYCERATEKINASE (Trypanosomabrucei) |
PF00162(PGK) | 4 | ASN A 26HIS A 62GLY A 68ASN A 133 | 3PG A 423 (-3.9A)3PG A 423 (-4.1A)NoneNone | 1.11A | 5x7pA-13pkA:undetectable | 5x7pA-13pkA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aql | BILE-SALT ACTIVATEDLIPASE (Bos taurus) |
PF00135(COesterase) | 4 | HIS A 435ASP A 438GLY A 315ASN A 317 | None | 1.12A | 5x7pA-1aqlA:0.1 | 5x7pA-1aqlA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqg | D-GLUCARATEDEHYDRATASE (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | HIS A 38ASP A 241GLY A 214ASN A 33 | None | 0.94A | 5x7pA-1bqgA:undetectable | 5x7pA-1bqgA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fno | PEPTIDASE T (Salmonellaenterica) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | ASP A 196ASP A 357GLY A 358ASN A 370 | ZN A 501 (-2.1A)NoneNoneNone | 0.95A | 5x7pA-1fnoA:0.0 | 5x7pA-1fnoA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i9z | PHOSPHATIDYLINOSITOLPHOSPHATEPHOSPHATASE (Schizosaccharomycespombe) |
PF03372(Exo_endo_phos) | 4 | ASN A 742HIS A 699GLY A 569ASN A 566 | NoneNoneNone CA A 301 ( 4.6A) | 1.13A | 5x7pA-1i9zA:undetectable | 5x7pA-1i9zA:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofm | CHONDROITINASE B (Pedobacterheparinus) |
PF14592(Chondroitinas_B) | 4 | ASN A 358HIS A 356ASP A 401GLY A 422 | None | 0.93A | 5x7pA-1ofmA:0.0 | 5x7pA-1ofmA:16.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1osm | OMPK36 (Klebsiellapneumoniae) |
PF00267(Porin_1) | 4 | ASN A 163ASP A 172GLY A 173ASN A 170 | None | 0.87A | 5x7pA-1osmA:undetectable | 5x7pA-1osmA:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3c | GLUTAMYL-ENDOPEPTIDASE (Bacillusintermedius) |
PF00089(Trypsin) | 5 | ASN A 196HIS A 186ASP A 135GLY A 134ASN A 170 | None | 1.36A | 5x7pA-1p3cA:undetectable | 5x7pA-1p3cA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgd | PROTEIN(TRANSKETOLASE) (Escherichiacoli) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ASP A 183ASP A 155GLY A 156ASN A 64 | None CA A 675 (-3.3A)TPP A 670 ( 3.5A)None | 1.06A | 5x7pA-1qgdA:0.0 | 5x7pA-1qgdA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suw | PROBABLE INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Archaeoglobusfulgidus) |
PF01513(NAD_kinase) | 4 | ASN A 234HIS A 78ASP A 49GLY A 48 | NoneNoneNAP A3075 (-4.2A)NAP A3075 (-3.4A) | 1.08A | 5x7pA-1suwA:undetectable | 5x7pA-1suwA:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t70 | PHOSPHATASE (Deinococcusradiodurans) |
PF13277(YmdB) | 4 | ASN A 65HIS A 66GLY A 205ASN A 38 | None | 1.14A | 5x7pA-1t70A:2.1 | 5x7pA-1t70A:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t70 | PHOSPHATASE (Deinococcusradiodurans) |
PF13277(YmdB) | 4 | HIS A 66ASP A 8GLY A 205ASN A 38 | None | 0.94A | 5x7pA-1t70A:2.1 | 5x7pA-1t70A:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t71 | PHOSPHATASE (Mycoplasmapneumoniae) |
PF13277(YmdB) | 4 | ASN A 71HIS A 72GLY A 216ASN A 44 | FE A 302 (-2.8A)NoneNone FE A 301 (-2.7A) | 0.62A | 5x7pA-1t71A:undetectable | 5x7pA-1t71A:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t71 | PHOSPHATASE (Mycoplasmapneumoniae) |
PF13277(YmdB) | 4 | HIS A 72ASP A 12GLY A 216ASN A 44 | None FE A 301 (-3.2A)None FE A 301 (-2.7A) | 1.03A | 5x7pA-1t71A:undetectable | 5x7pA-1t71A:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z0u | PROBABLE INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Archaeoglobusfulgidus) |
PF01513(NAD_kinase) | 4 | ASN A 234HIS A 78ASP A 49GLY A 48 | NoneNoneNAP A3076 (-4.2A)NAP A3076 ( 3.7A) | 1.10A | 5x7pA-1z0uA:undetectable | 5x7pA-1z0uA:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zyl | HYPOTHETICAL PROTEINYIHE (Escherichiacoli) |
PF01636(APH) | 4 | ASN A 39ASP A 217ASP A 201GLY A 200 | None | 1.06A | 5x7pA-1zylA:undetectable | 5x7pA-1zylA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8x | DIHYDROLIPOYLDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ASN A 119HIS A 303ASP A 136ASN A 137 | None | 1.04A | 5x7pA-2a8xA:2.1 | 5x7pA-2a8xA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2az4 | HYPOTHETICAL PROTEINEF2904 (Enterococcusfaecalis) |
PF12706(Lactamase_B_2) | 4 | HIS A 195ASP A 168GLY A 260ASN A 264 | None | 1.15A | 5x7pA-2az4A:undetectable | 5x7pA-2az4A:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0t | NADP ISOCITRATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF03971(IDH) | 4 | ASN A 177ASP A 450ASP A 428GLY A 429 | None | 1.11A | 5x7pA-2b0tA:undetectable | 5x7pA-2b0tA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b2x | ANTIBODY AQC2 FAB (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | ASN L 30HIS L 31ASP H 101GLY H 102 | NoneNone MG A 400 (-3.6A)None | 1.03A | 5x7pA-2b2xL:undetectable | 5x7pA-2b2xL:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cwa | SINGLE-STRANDBINDING PROTEIN (Thermusthermophilus) |
PF00436(SSB) | 4 | HIS A 171ASP A 102GLY A 80ASN A 6 | None | 0.97A | 5x7pA-2cwaA:undetectable | 5x7pA-2cwaA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ek8 | AMINOPEPTIDASE (Aneurinibacillussp. AM-1) |
PF02225(PA)PF04389(Peptidase_M28) | 4 | ASN A 274ASP A 230ASP A 240GLY A 237 | NoneNone ZN A1001 ( 2.4A)None | 1.11A | 5x7pA-2ek8A:undetectable | 5x7pA-2ek8A:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j1n | OUTER MEMBRANEPROTEIN C (Escherichiacoli) |
PF00267(Porin_1) | 4 | ASN A 168ASP A 178GLY A 179ASN A 176 | None | 0.86A | 5x7pA-2j1nA:undetectable | 5x7pA-2j1nA:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqh | PUTATIVE ISOMERASE (Streptomycescoelicolor) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASN A 246ASP A 224GLY A 171ASN A 199 | None | 1.06A | 5x7pA-2oqhA:3.2 | 5x7pA-2oqhA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2paa | PHOSPHOGLYCERATEKINASE, TESTISSPECIFIC (Mus musculus) |
PF00162(PGK) | 4 | ASN A 25ASP A 67GLY A 68ASN A 120 | None | 1.01A | 5x7pA-2paaA:undetectable | 5x7pA-2paaA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfr | PURPLE ACIDPHOSPHATASE (Phaseolusvulgaris) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 4 | ASN A 201HIS A 202ASP A 135GLY A 366 | ZN A 434 ( 2.7A)SO4 A 435 (-4.2A) FE A 433 ( 2.9A)None | 1.00A | 5x7pA-2qfrA:undetectable | 5x7pA-2qfrA:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rbd | BH2358 PROTEIN (Bacillushalodurans) |
PF11553(DUF3231) | 4 | ASN A 153ASP A 46TRP A 156GLY A 43 | None | 1.14A | 5x7pA-2rbdA:undetectable | 5x7pA-2rbdA:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2voy | CATION-TRANSPORTINGATPASESARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 1 (Archaeoglobusfulgidus;Oryctolaguscuniculus) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase) | 4 | ASP I 654ASP I 653GLY I 636ASN H 330 | None | 1.05A | 5x7pA-2voyI:undetectable | 5x7pA-2voyI:8.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vzp | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF16990(CBM_35) | 4 | ASN A 21HIS A 22GLY A 119ASN A 121 | NoneNoneNoneEDO A1130 (-3.4A) | 1.03A | 5x7pA-2vzpA:8.7 | 5x7pA-2vzpA:6.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vzp | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF16990(CBM_35) | 4 | ASN A 21HIS A 22TRP A 90ASN A 121 | NoneNoneNoneEDO A1130 (-3.4A) | 0.33A | 5x7pA-2vzpA:8.7 | 5x7pA-2vzpA:6.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w87 | ESTERASE D (Cellvibriojaponicus) |
PF03422(CBM_6) | 4 | ASN A 29HIS A 30TRP A 99ASN A 130 | GCU A1150 ( 4.7A)GCU A1150 (-4.0A)GCU A1150 (-3.9A)GCU A1150 (-3.1A) | 0.21A | 5x7pA-2w87A:6.7 | 5x7pA-2w87A:7.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xe5 | OUTER MEMBRANE PORINC (Escherichiacoli) |
PF00267(Porin_1) | 4 | ASN A 164ASP A 175GLY A 176ASN A 173 | None | 0.85A | 5x7pA-2xe5A:undetectable | 5x7pA-2xe5A:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z06 | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA0625 (Thermusthermophilus) |
PF13277(YmdB) | 4 | ASN A 65HIS A 66GLY A 202ASN A 38 | CO A 253 (-2.5A)NoneNoneNone | 0.73A | 5x7pA-2z06A:undetectable | 5x7pA-2z06A:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ajz | ANCESTRAL CONGERINCON-ANC (-) |
PF00337(Gal-bind_lectin) | 4 | ASN A 31HIS A 42ASP A 64GLY A 65 | NoneGAL A 133 (-4.0A)NoneNone | 1.07A | 5x7pA-3ajzA:undetectable | 5x7pA-3ajzA:8.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cze | SUCROSE HYDROLASE (Xanthomonascitri) |
PF00128(Alpha-amylase) | 4 | ASN A 446HIS A 518ASP A 137GLY A 138 | NoneNoneTRS A6646 (-3.0A)TRS A6646 ( 4.8A) | 1.12A | 5x7pA-3czeA:undetectable | 5x7pA-3czeA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmb | N-ACETYLMURAMOYL-L-ALANINE AMIDASE XLYA (Bacillussubtilis) |
PF01510(Amidase_2) | 4 | HIS A 43ASP A 39ASP A 99GLY A 100 | None | 0.99A | 5x7pA-3hmbA:undetectable | 5x7pA-3hmbA:7.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ian | CHITINASE (Lactococcuslactis) |
PF00704(Glyco_hydro_18) | 4 | ASN A 225ASP A 158GLY A 156ASN A 81 | None | 1.12A | 5x7pA-3ianA:undetectable | 5x7pA-3ianA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ife | PEPTIDASE T (Bacillusanthracis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | ASP A 199ASP A 359GLY A 360ASN A 372 | ZN A 411 (-1.9A)NoneNoneNone | 1.01A | 5x7pA-3ifeA:undetectable | 5x7pA-3ifeA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kom | TRANSKETOLASE (Francisellatularensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ASP A 185ASP A 157GLY A 158ASN A 66 | NoneNoneOCS A 159 ( 2.4A)None | 1.05A | 5x7pA-3komA:undetectable | 5x7pA-3komA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzn | GLUCARATEDEHYDRATASE (Chromohalobactersalexigens) |
PF13378(MR_MLE_C) | 4 | HIS A 27ASP A 231GLY A 204ASN A 22 | SO4 A 450 (-4.1A)NoneNoneSO4 A 450 (-3.2A) | 1.12A | 5x7pA-3mznA:undetectable | 5x7pA-3mznA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n9v | TYPE IIINOSITOL-1,4,5-TRISPHOSPHATE5-PHOSPHATASE (Homo sapiens) |
PF03372(Exo_endo_phos) | 4 | ASN A 449HIS A 400GLY A 276ASN A 273 | NoneNoneNone MG A 61 ( 4.8A) | 1.10A | 5x7pA-3n9vA:undetectable | 5x7pA-3n9vA:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nr8 | PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE5-PHOSPHATASE 2 (Homo sapiens) |
no annotation | 4 | ASN B 432HIS B 718GLY B 565ASN B 609 | None | 0.97A | 5x7pA-3nr8B:undetectable | 5x7pA-3nr8B:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntl | ACIDGLUCOSE-1-PHOSPHATEPHOSPHATASE (Enterobactercloacae) |
PF00328(His_Phos_2) | 4 | ASN A 25ASP A 209ASP A 288ASN A 205 | IHP A 550 ( 4.4A)IHP A 550 (-3.6A)IHP A 550 (-2.4A)IHP A 550 ( 4.2A) | 1.11A | 5x7pA-3ntlA:undetectable | 5x7pA-3ntlA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxl | GLUCARATEDEHYDRATASE (Burkholderialata) |
PF13378(MR_MLE_C) | 4 | ASN A 309ASP A 281GLY A 228ASN A 257 | MG A 476 (-2.4A)NoneNone MG A 476 ( 4.3A) | 1.13A | 5x7pA-3nxlA:undetectable | 5x7pA-3nxlA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxl | GLUCARATEDEHYDRATASE (Burkholderialata) |
PF13378(MR_MLE_C) | 4 | HIS A 36ASP A 255GLY A 228ASN A 31 | CO3 A 477 (-4.0A) MG A 476 (-2.8A)NoneCO3 A 477 ( 3.8A) | 1.12A | 5x7pA-3nxlA:undetectable | 5x7pA-3nxlA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oz7 | PHOSPHOGLYCERATEKINASE (Plasmodiumfalciparum) |
PF00162(PGK) | 4 | ASN A 26HIS A 63GLY A 69ASN A 120 | SO4 A 601 ( 4.5A)SO4 A 601 (-4.4A)NoneNone | 1.13A | 5x7pA-3oz7A:undetectable | 5x7pA-3oz7A:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p0w | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Ralstoniapickettii) |
PF13378(MR_MLE_C) | 4 | HIS A 32ASP A 251GLY A 224ASN A 27 | GKR A 472 (-3.9A) MG A 471 ( 2.6A)NoneGKR A 472 (-3.5A) | 1.12A | 5x7pA-3p0wA:undetectable | 5x7pA-3p0wA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qt4 | CATHEPSIN-L-LIKEMIDGUT CYSTEINEPROTEINASE (Tenebriomolitor) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 4 | ASP A 249ASP A 234GLY A 302ASN A 300 | None | 0.89A | 5x7pA-3qt4A:undetectable | 5x7pA-3qt4A:14.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmv | GLYCOGENIN-1 (Homo sapiens) |
PF01501(Glyco_transf_8) | 4 | ASN A 188HIS A 212ASP A 163GLY A 162 | None MN A 263 ( 3.3A)NoneNone | 1.07A | 5x7pA-3rmvA:undetectable | 5x7pA-3rmvA:12.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwl | CYTOCHROME P450ALKANE HYDROXYLASE 1CYP153A7 (Sphingopyxismacrogoltabida) |
PF00067(p450) | 5 | ASN A 402HIS A 304ASP A 85ASP A 86GLY A 80 | None | 1.33A | 5x7pA-3rwlA:undetectable | 5x7pA-3rwlA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3to3 | PETROBACTINBIOSYNTHESIS PROTEINASBB (Bacillusanthracis) |
PF04183(IucA_IucC)PF06276(FhuF) | 4 | ASN A 355ASP A 262GLY A 264ASN A 197 | NoneEDO A 618 (-4.3A)EDO A 618 ( 4.1A)None | 1.15A | 5x7pA-3to3A:undetectable | 5x7pA-3to3A:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk1 | TRANSKETOLASE (Burkholderiathailandensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ASP A 203ASP A 175GLY A 176ASN A 84 | NoneNoneOCS A 177 ( 2.4A)OCS A 177 ( 4.2A) | 1.04A | 5x7pA-3uk1A:undetectable | 5x7pA-3uk1A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va8 | PROBABLE DEHYDRATASE (Fusariumgraminearum) |
PF13378(MR_MLE_C) | 4 | HIS A 29ASP A 220GLY A 193ASN A 24 | SO4 A 424 (-3.8A) MG A 425 ( 2.4A)NoneSO4 A 424 (-3.8A) | 1.12A | 5x7pA-3va8A:undetectable | 5x7pA-3va8A:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vdg | PROBABLE GLUCARATEDEHYDRATASE (Mycolicibacteriumsmegmatis) |
PF13378(MR_MLE_C) | 4 | HIS A 30ASP A 222GLY A 195ASN A 25 | ACT A 504 (-4.0A) NA A 502 (-2.9A)NoneACT A 504 (-3.9A) | 1.11A | 5x7pA-3vdgA:undetectable | 5x7pA-3vdgA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vx8 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME ATG7 (Arabidopsisthaliana) |
no annotation | 4 | ASP D 40ASP D 39GLY D 37ASN D 97 | None | 1.07A | 5x7pA-3vx8D:undetectable | 5x7pA-3vx8D:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnp | CYCLOISOMALTOOLIGOSACCHARIDEGLUCANOTRANSFERASE (Bacilluscirculans) |
PF13199(Glyco_hydro_66)PF16990(CBM_35) | 5 | ASN A 438HIS A 439ASP A 449TRP A 506ASN A 539 | None | 0.32A | 5x7pA-3wnpA:9.2 | 5x7pA-3wnpA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyp | CIP1 (Trichodermareesei) |
no annotation | 4 | ASP A 174ASP A 121GLY A 126ASN A 171 | None | 1.12A | 5x7pA-3zypA:7.1 | 5x7pA-3zypA:11.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b2o | YMDBPHOSPHODIESTERASE (Bacillussubtilis) |
PF13277(YmdB) | 4 | ASN A 67HIS A 68GLY A 207ASN A 40 | PO4 A1265 ( 2.6A)PO4 A1265 (-3.7A)NoneFE2 A1266 ( 2.5A) | 0.70A | 5x7pA-4b2oA:2.3 | 5x7pA-4b2oA:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b2o | YMDBPHOSPHODIESTERASE (Bacillussubtilis) |
PF13277(YmdB) | 4 | HIS A 68ASP A 8GLY A 207ASN A 40 | PO4 A1265 (-3.7A)FE2 A1266 (-3.1A)NoneFE2 A1266 ( 2.5A) | 0.96A | 5x7pA-4b2oA:2.3 | 5x7pA-4b2oA:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgv | MALATE DEHYDROGENASE (Picrophilustorridus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ASP A 184ASP A 129TRP A 302GLY A 276 | None | 0.80A | 5x7pA-4bgvA:undetectable | 5x7pA-4bgvA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | HIS A 25ASP A 217GLY A 190ASN A 20 | PO4 A 501 (-4.0A)NoneNonePO4 A 501 (-3.6A) | 1.11A | 5x7pA-4dhgA:undetectable | 5x7pA-4dhgA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdd | TRANSPORTIN-1 (Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 4 | HIS A 858ASP A 866GLY A 865ASN A 862 | None | 1.01A | 5x7pA-4fddA:undetectable | 5x7pA-4fddA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwm | PROPIONATE KINASE (Salmonellaenterica) |
PF00871(Acetate_kinase) | 4 | ASP A 196ASP A 319GLY A 198ASN A 215 | None | 1.14A | 5x7pA-4fwmA:undetectable | 5x7pA-4fwmA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8t | GLUCARATEDEHYDRATASE (Actinobacillussuccinogenes) |
PF13378(MR_MLE_C) | 4 | HIS A 28ASP A 231GLY A 204ASN A 23 | SO4 A 501 (-4.2A) NA A 502 (-2.3A)NoneSO4 A 501 (-3.3A) | 1.12A | 5x7pA-4g8tA:undetectable | 5x7pA-4g8tA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4haq | GH7 FAMILY PROTEIN (Limnoriaquadripunctata) |
PF00840(Glyco_hydro_7) | 4 | ASN A 218ASP A 426GLY A 160ASN A 398 | None | 1.10A | 5x7pA-4haqA:4.8 | 5x7pA-4haqA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hhq | SERUM PARAOXONASE BYDIRECTED EVOLUTION (syntheticconstruct) |
PF01731(Arylesterase) | 4 | ASN A 168ASP A 269GLY A 344ASN A 270 | CA A 402 ( 3.8A) CA A 402 (-2.6A)None CA A 402 ( 3.8A) | 1.09A | 5x7pA-4hhqA:undetectable | 5x7pA-4hhqA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hn8 | D-GLUCARATEDEHYDRATASE (Pseudomonasmendocina) |
PF13378(MR_MLE_C) | 4 | HIS A 34ASP A 252GLY A 225ASN A 29 | GOL A 502 (-4.3A)NoneNoneGOL A 502 (-3.5A) | 1.10A | 5x7pA-4hn8A:undetectable | 5x7pA-4hn8A:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyr | GLUCARATEDEHYDRATASE (Acidaminococcusintestini) |
PF13378(MR_MLE_C) | 4 | HIS A 27ASP A 231GLY A 204ASN A 22 | CL A 502 (-4.2A)NoneNoneNone | 1.14A | 5x7pA-4hyrA:undetectable | 5x7pA-4hyrA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jq9 | DIHYDROLIPOYLDEHYDROGENASE (Escherichiacoli) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ASN A 123HIS A 307ASP A 139ASN A 140 | SO4 A 502 (-4.9A)NoneNoneNone | 1.07A | 5x7pA-4jq9A:undetectable | 5x7pA-4jq9A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxf | TREHALOSE SYNTHASE (Mycobacteriumtuberculosis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 4 | ASN A 348HIS A 349ASP A 422GLY A 431 | GOL A 705 (-2.9A)GOL A 705 (-4.4A)NoneNone | 1.09A | 5x7pA-4lxfA:2.6 | 5x7pA-4lxfA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mae | METHANOLDEHYDROGENASE (Methylacidiphilumfumariolicum) |
PF13360(PQQ_2) | 4 | ASN A 406ASP A 388ASP A 301GLY A 302 | NonePQQ A 602 (-2.7A) CE A 601 ( 2.3A)None | 1.13A | 5x7pA-4maeA:undetectable | 5x7pA-4maeA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mb5 | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18)PF16403(DUF5011) | 4 | ASN A 216ASP A 149GLY A 147ASN A 67 | None | 1.13A | 5x7pA-4mb5A:3.9 | 5x7pA-4mb5A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n03 | ABC-TYPEBRANCHED-CHAIN AMINOACID TRANSPORTSYSTEMS PERIPLASMICCOMPONENT-LIKEPROTEIN (Thermomonosporacurvata) |
PF13458(Peripla_BP_6) | 4 | ASN A 273ASP A 169ASP A 167GLY A 205 | PLM A 601 ( 3.8A)NoneNoneNone | 1.01A | 5x7pA-4n03A:undetectable | 5x7pA-4n03A:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nf7 | ENDO-1,4-BETA-GLUCANASE CEL5C (Butyrivibrioproteoclasticus) |
PF00150(Cellulase) | 4 | ASN A 378ASP A 356GLY A 53ASN A 77 | None | 1.11A | 5x7pA-4nf7A:undetectable | 5x7pA-4nf7A:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oij | C-C MOTIF CHEMOKINE1 (Homo sapiens) |
PF00048(IL8) | 4 | HIS A 68ASP A 54GLY A 39ASN A 30 | SO4 A 105 ( 3.9A)NoneNoneSO4 A 105 (-3.6A) | 1.13A | 5x7pA-4oijA:undetectable | 5x7pA-4oijA:4.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2b | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Ochrobactrumanthropi) |
PF01547(SBP_bac_1) | 4 | ASN A 144HIS A 146TRP A 272ASN A 303 | NoneGLC A 501 (-4.4A)GLC A 501 (-3.5A)GLC A 501 (-3.9A) | 1.13A | 5x7pA-4r2bA:undetectable | 5x7pA-4r2bA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v39 | SIALYLTRANSFERASE (Pasteurelladagmatis) |
PF11477(PM0188) | 4 | ASN A 58HIS A 7GLY A 115ASN A 82 | None | 1.03A | 5x7pA-4v39A:undetectable | 5x7pA-4v39A:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5z | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18) | 4 | ASN A 216ASP A 149GLY A 147ASN A 67 | None | 1.12A | 5x7pA-4w5zA:undetectable | 5x7pA-4w5zA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wa0 | POSSIBLE ADHESIN (Caldicellulosiruptorkronotskyensis) |
no annotation | 4 | ASN A 562ASP A 295GLY A 275ASN A 257 | None | 1.02A | 5x7pA-4wa0A:undetectable | 5x7pA-4wa0A:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeu | TRANSKETOLASE (Pseudomonasaeruginosa) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ASP A 183ASP A 155GLY A 156ASN A 64 | None | 1.05A | 5x7pA-4xeuA:undetectable | 5x7pA-4xeuA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awp | ISOMALTODEXTRANASE (Arthrobacterglobiformis) |
no annotation | 5 | ASN A 488HIS A 489ASP A 499TRP A 566ASN A 598 | GLC A 704 ( 4.4A)GLC A 704 (-3.9A)NoneGLC A 704 (-3.6A)GLC A 704 (-3.0A) | 0.17A | 5x7pA-5awpA:7.4 | 5x7pA-5awpA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2v | HYDRAZINE SYNTHASEALPHA SUBUNIT (CandidatusKueneniastuttgartiensis) |
no annotation | 4 | HIS A 453ASP A 246GLY A 235ASN A 432 | None | 0.96A | 5x7pA-5c2vA:undetectable | 5x7pA-5c2vA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d62 | AGGLUTININ (Marasmiusoreades) |
PF14200(RicinB_lectin_2) | 4 | ASN A 95HIS A 97ASP A 28GLY A 29 | GLA A 305 (-3.3A)GLA A 305 (-3.9A)GLA A 306 ( 4.9A)None | 0.85A | 5x7pA-5d62A:undetectable | 5x7pA-5d62A:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ets | 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINEPYROPHOSPHOKINASE (Staphylococcusaureus) |
no annotation | 4 | ASN B 11ASP B 97GLY B 7ASN B 56 | 5RX B 202 (-3.8A) MG B 204 (-2.5A)None5RX B 202 (-3.2A) | 1.06A | 5x7pA-5etsB:undetectable | 5x7pA-5etsB:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | ASP A 998TRP A1051GLY A1081ASN A1083 | GLC A1113 (-4.0A)GLC A1112 (-3.6A)GLC A1113 (-3.2A)GLC A1112 (-2.9A) | 0.93A | 5x7pA-5f7uA:20.9 | 5x7pA-5f7uA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | HIS A 985TRP A1051GLY A 996ASN A1083 | GLC A1112 (-3.9A)GLC A1112 (-3.6A)GLC A1112 (-3.6A)GLC A1112 (-2.9A) | 1.12A | 5x7pA-5f7uA:20.9 | 5x7pA-5f7uA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 4 | HIS A 985TRP A1051GLY A1081ASN A1083 | GLC A1112 (-3.9A)GLC A1112 (-3.6A)GLC A1113 (-3.2A)GLC A1112 (-2.9A) | 0.52A | 5x7pA-5f7uA:20.9 | 5x7pA-5f7uA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fvn | OMPC PORIN (Enterobactercloacae) |
PF00267(Porin_1) | 4 | ASN A 164ASP A 174GLY A 175ASN A 172 | NoneL1L A 414 ( 2.9A)NoneNone | 0.82A | 5x7pA-5fvnA:undetectable | 5x7pA-5fvnA:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqf | LACTO-N-BIOSIDASE (Bifidobacteriumlongum) |
no annotation | 4 | ASP A 411ASP A 341GLY A 340ASN A 409 | NAG A 704 (-3.5A)NAG A 704 ( 4.2A)NoneNone | 1.05A | 5x7pA-5gqfA:undetectable | 5x7pA-5gqfA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i51 | TRANSKETOLASE (Scheffersomycesstipitis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ASP A 183ASP A 155GLY A 156ASN A 64 | None CA A 703 ( 3.2A)TPP A 701 (-3.5A)None | 1.09A | 5x7pA-5i51A:undetectable | 5x7pA-5i51A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u04 | ZIKA VIRUS NS5 RDRP (Zika virus) |
PF00972(Flavi_NS5) | 4 | HIS A 714ASP A 846GLY A 842ASN A 716 | ZN A1001 (-3.2A)NoneNone ZN A1001 ( 4.6A) | 1.14A | 5x7pA-5u04A:undetectable | 5x7pA-5u04A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz5 | 56 KDA U1 SMALLNUCLEARRIBONUCLEOPROTEINCOMPONENTU1 SMALL NUCLEARRIBONUCLEOPROTEINCOMPONENT PRP42 (Saccharomycescerevisiae) |
no annotation | 4 | ASN D 19ASP G 262ASP G 258GLY G 259 | None | 1.13A | 5x7pA-5uz5D:undetectable | 5x7pA-5uz5D:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7h | CYCLOISOMALTOOLIGOSACCHARIDEGLUCANOTRANSFERASE (Paenibacillussp. 598K) |
PF13199(Glyco_hydro_66)PF16990(CBM_35) | 5 | ASN A 439HIS A 440ASP A 450TRP A 507ASN A 540 | GLC A 811 ( 4.7A)GLC A 811 ( 3.7A)NoneGLC A 811 ( 3.9A)GLC A 811 ( 2.8A) | 0.28A | 5x7pA-5x7hA:3.9 | 5x7pA-5x7hA:23.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 7 | ASN A 875HIS A 876ASP A 886ASP A 889TRP A 943GLY A 975ASN A 977 | None | 0.17A | 5x7pA-5x7sA:59.0 | 5x7pA-5x7sA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 4 | ASP A 491ASP A 529GLY A 532ASN A 534 | None | 1.12A | 5x7pA-5x7sA:59.0 | 5x7pA-5x7sA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 4 | HIS A1009ASP A1019TRP A1077ASN A1109 | None | 0.27A | 5x7pA-5x7sA:59.0 | 5x7pA-5x7sA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINES1RIBOSOMAL PROTEINUS11 (Toxoplasmagondii) |
PF00411(Ribosomal_S11)PF01015(Ribosomal_S3Ae) | 4 | ASN B 95ASP O 28GLY O 29ASN B 42 | None | 0.92A | 5x7pA-5xxuB:undetectable | 5x7pA-5xxuB:11.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c1d | UNCONVENTIONALMYOSIN-IB (Rattusnorvegicus) |
no annotation | 4 | ASN P 187ASP P 171GLY P 183ASN P 369 | None | 1.02A | 5x7pA-6c1dP:undetectable | 5x7pA-6c1dP:5.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dft | () |
no annotation | 4 | ASN B 271HIS B 267ASP A 328GLY A 163 | NoneNoneNAD A 502 (-3.6A)NAD A 502 (-3.5A) | 1.02A | 5x7pA-6dftB:undetectable | 5x7pA-6dftB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f91 | PUTATIVEALPHA-1,2-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | ASN A 656ASP A 710ASP A 714GLY A 715 | None | 0.97A | 5x7pA-6f91A:6.1 | 5x7pA-6f91A:5.33 |