SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_A_ACRA1421

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 MET A 313
TYR A 237
GLY A 245
GLY A 246
 None
3AT  A1000 (-4.7A)
None
3AT  A1000 (-3.0A)
 0.84A 5x7pA-1f5aA:
undetectable		 5x7pA-1f5aA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 TYR A 101
TYR A 135
GLY A 131
GLY A 130
 None
 1.22A 5x7pA-1ixkA:
2.5		 5x7pA-1ixkA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 MET A 269
TYR A 160
GLY A 176
GLY A  75
 None
 0.93A 5x7pA-1kcwA:
1.2		 5x7pA-1kcwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 MET A 968
TYR A 860
GLY A 876
GLY A 790
 None
 1.16A 5x7pA-1kcwA:
1.2		 5x7pA-1kcwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 520
TYR A 521
GLY A 536
GLY A 431
 None
 1.14A 5x7pA-1kcwA:
1.2		 5x7pA-1kcwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 MET A  67
TYR A 163
GLY A 166
GLY A 178
 GOL  A 531 (-3.4A)
None
None
None
 1.11A 5x7pA-1kfwA:
1.5		 5x7pA-1kfwA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpl HYPOTHETICAL 25.4
KDA PROTEIN F53F4.3
IN CHROMOSOME V

(Caenorhabditis
elegans) 		PF01302
(CAP_GLY) 		4 TYR A 184
TYR A 207
GLY A 208
GLY A 209
 None
 0.73A 5x7pA-1lplA:
undetectable		 5x7pA-1lplA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moe ANTI-CEA MAB T84.66

(Mus musculus) 		PF07686
(V-set) 		4 TYR A  91
TYR A  90
GLY A 105
GLY A 104
 None
 1.22A 5x7pA-1moeA:
0.9		 5x7pA-1moeA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		4 MET A 166
TYR A 189
GLY A 149
GLY A 114
 None
 0.97A 5x7pA-1nd1A:
undetectable		 5x7pA-1nd1A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2

(Mus musculus) 		PF09258
(Glyco_transf_64) 		4 MET A 307
TYR A 209
TYR A 311
GLY A 262
 None
 1.11A 5x7pA-1omxA:
0.0		 5x7pA-1omxA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opg OPG2 FAB (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H 102
TYR H  32
GLY H  53
GLY H  54
 None
 0.71A 5x7pA-1opgH:
1.1		 5x7pA-1opgH:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 TYR A  41
TYR A  52
GLY A  40
GLY A  39
 None
 1.11A 5x7pA-1pv9A:
undetectable		 5x7pA-1pv9A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		4 MET A 134
TYR A  58
GLY A  57
GLY A  21
 None
 1.12A 5x7pA-1qvbA:
1.2		 5x7pA-1qvbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rv9 CONSERVED
HYPOTHETICAL PROTEIN
NMB0706

(Neisseria
meningitidis) 		PF02578
(Cu-oxidase_4) 		4 TYR A 163
TYR A 223
GLY A 224
GLY A 225
 None
 1.23A 5x7pA-1rv9A:
1.8		 5x7pA-1rv9A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 MET B1733
TYR B1689
GLY B1705
GLY B1604
 None
 1.14A 5x7pA-1sddB:
4.8		 5x7pA-1sddB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 TYR B1689
TYR B1690
GLY B1705
GLY B1604
 None
 1.11A 5x7pA-1sddB:
4.8		 5x7pA-1sddB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvc GLUCOSE-1-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		4 MET A  42
TYR A 129
GLY A 190
GLY A 189
 None
 1.15A 5x7pA-1wvcA:
undetectable		 5x7pA-1wvcA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 TYR A  44
TYR A  55
GLY A  43
GLY A  42
 None
 1.17A 5x7pA-1wy2A:
undetectable		 5x7pA-1wy2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 TYR A  11
TYR A 312
GLY A 313
GLY A 321
 None
 1.00A 5x7pA-2a7nA:
undetectable		 5x7pA-2a7nA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 MET A 543
TYR A 530
GLY A 531
GLY A 532
 None
 1.08A 5x7pA-2bklA:
undetectable		 5x7pA-2bklA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		4 MET A 187
TYR A 218
GLY A  83
GLY A  82
 None
 1.12A 5x7pA-2c7bA:
undetectable		 5x7pA-2c7bA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 147
TYR A 248
GLY A 246
GLY A 245
 None
 1.20A 5x7pA-2cxeA:
undetectable		 5x7pA-2cxeA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlw DOCKING PROTEIN 2,
ISOFORM A

(Homo sapiens) 		PF02174
(IRS) 		4 MET A  15
TYR A  52
GLY A  43
GLY A  44
 None
 1.19A 5x7pA-2dlwA:
undetectable		 5x7pA-2dlwA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 MET A 789
TYR A 824
GLY A 822
GLY A 821
 None
 1.18A 5x7pA-2ec5A:
undetectable		 5x7pA-2ec5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
None
None
ASP  A7001 ( 3.5A)
 0.91A 5x7pA-2himA:
3.1		 5x7pA-2himA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		4 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
None
None
ACT  A 601 ( 4.0A)
 0.89A 5x7pA-2ocdA:
undetectable		 5x7pA-2ocdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 MET A 221
TYR A 133
GLY A 171
GLY A 174
 None
 1.13A 5x7pA-2qtyA:
undetectable		 5x7pA-2qtyA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		4 MET A 142
TYR A 151
GLY A 150
GLY A 149
 None
 1.20A 5x7pA-2rchA:
undetectable		 5x7pA-2rchA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uud NQ10-1.12 ANTI-PHOX
ANTIBODY

(Mus musculus) 		PF07686
(V-set) 		4 TYR K  87
TYR K  86
GLY K 101
GLY K 100
 None
 1.13A 5x7pA-2uudK:
2.0		 5x7pA-2uudK:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uux TRYPTASE INHIBITOR

(Rhipicephalus
appendiculatus) 		no annotation 4 TYR A  46
TYR A  45
GLY A  62
GLY A  61
 None
 1.05A 5x7pA-2uuxA:
undetectable		 5x7pA-2uuxA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus) 		PF06470
(SMC_hinge) 		4 TYR B 668
TYR B 667
GLY B 666
GLY B 665
 None
 0.75A 5x7pA-2wd5B:
undetectable		 5x7pA-2wd5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		4 TYR A 170
TYR A   3
GLY A  34
GLY A  33
 OTP  A1174 (-4.7A)
None
None
None
 1.13A 5x7pA-2x32A:
undetectable		 5x7pA-2x32A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqw COMPLEMENT C3

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 TYR A 268
TYR A 269
GLY A 270
GLY A 271
 None
 0.95A 5x7pA-2xqwA:
undetectable		 5x7pA-2xqwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 TYR B1239
TYR B1240
GLY B1241
GLY B1242
 None
 1.01A 5x7pA-2xwbB:
2.6		 5x7pA-2xwbB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		4 TYR A 109
TYR A 112
GLY A 113
GLY A 114
 None
 1.06A 5x7pA-3adrA:
undetectable		 5x7pA-3adrA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		4 MET A1388
TYR A1348
GLY A1349
GLY A1351
 None
 1.20A 5x7pA-3b13A:
undetectable		 5x7pA-3b13A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 TYR A 180
TYR A 235
GLY A 236
GLY A 237
 None
 1.10A 5x7pA-3bb7A:
undetectable		 5x7pA-3bb7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clo TRANSCRIPTIONAL
REGULATOR

(Bacteroides
thetaiotaomicron) 		PF00196
(GerE) 		4 MET A 128
TYR A 160
GLY A  43
GLY A  42
 None
 1.21A 5x7pA-3cloA:
undetectable		 5x7pA-3cloA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 TYR A  16
TYR A 100
GLY A 101
GLY A  11
 None
 1.14A 5x7pA-3cq9A:
4.2		 5x7pA-3cq9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 MET A  97
TYR A 106
GLY A 105
GLY A 104
 None
 1.19A 5x7pA-3danA:
undetectable		 5x7pA-3danA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		4 MET A 142
TYR A 247
GLY A 250
GLY A 253
 None
 1.16A 5x7pA-3e48A:
undetectable		 5x7pA-3e48A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR

(Bacillus
anthracis) 		PF12207
(DUF3600) 		4 MET A  82
TYR A  62
GLY A  63
GLY A  67
 None
 0.90A 5x7pA-3fh3A:
undetectable		 5x7pA-3fh3A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		4 MET A 173
TYR A  78
GLY A  77
GLY A  76
 None
None
SO4  A 276 ( 4.6A)
None
 0.78A 5x7pA-3g23A:
undetectable		 5x7pA-3g23A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		4 MET A 164
TYR A 187
GLY A 147
GLY A 112
 None
 1.14A 5x7pA-3gboA:
undetectable		 5x7pA-3gboA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		4 MET A  67
TYR A  12
GLY A  42
GLY A  43
 None
None
None
GOL  A 154 ( 3.7A)
 0.66A 5x7pA-3grnA:
undetectable		 5x7pA-3grnA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 TYR A 283
TYR A 285
GLY A 307
GLY A 306
 None
NDP  A 401 (-4.0A)
None
None
 1.17A 5x7pA-3iupA:
4.0		 5x7pA-3iupA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy5 ANTIBODY FRAGMENT
IGG2A (LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 TYR A  88
TYR A  87
GLY A 102
GLY A 101
 None
 1.21A 5x7pA-3iy5A:
2.5		 5x7pA-3iy5A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 MET A 329
TYR A 305
GLY A 304
GLY A 303
 None
None
AZI  A 385 (-3.0A)
AZI  A 385 (-4.7A)
 1.22A 5x7pA-3jtmA:
undetectable		 5x7pA-3jtmA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvd TRANSCRIPTIONAL
REGULATORS

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		4 MET A 243
TYR A 272
GLY A 278
GLY A 321
 None
 1.13A 5x7pA-3jvdA:
undetectable		 5x7pA-3jvdA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TYR A 224
TYR A 225
GLY A 226
GLY A 256
 None
 1.05A 5x7pA-3kf3A:
2.8		 5x7pA-3kf3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 MET A 245
TYR A 139
GLY A 135
GLY A 130
 None
 1.12A 5x7pA-3lcrA:
1.7		 5x7pA-3lcrA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE

(Homo sapiens) 		PF05577
(Peptidase_S28) 		4 MET B 481
TYR B  89
GLY B 177
GLY B 178
 None
 0.69A 5x7pA-3n2zB:
undetectable		 5x7pA-3n2zB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 TYR A 401
TYR A 332
GLY A 333
GLY A 334
 None
 0.97A 5x7pA-3nafA:
2.9		 5x7pA-3nafA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
 0.80A 5x7pA-3ntxA:
2.8		 5x7pA-3ntxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TYR A 155
TYR A 413
GLY A 414
GLY A 415
 None
 1.18A 5x7pA-3pocA:
21.5		 5x7pA-3pocA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE

(Escherichia
coli) 		PF03629
(SASA) 		4 TYR A 282
TYR A 283
GLY A 284
GLY A  27
 None
 1.15A 5x7pA-3pt5A:
1.5		 5x7pA-3pt5A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rij SC_2CX5

(Thermus
thermophilus) 		PF04073
(tRNA_edit) 		4 TYR A  61
TYR A  54
GLY A  55
GLY A  56
 None
 1.15A 5x7pA-3rijA:
undetectable		 5x7pA-3rijA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u04 PEPTIDE DEFORMYLASE
1

(Ehrlichia
chaffeensis) 		PF01327
(Pep_deformylase) 		4 MET A  39
TYR A  90
GLY A  88
GLY A  87
 None
 0.92A 5x7pA-3u04A:
undetectable		 5x7pA-3u04A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		4 TYR A 236
TYR A 237
GLY A 238
GLY A 196
 None
 1.22A 5x7pA-3v1zA:
undetectable		 5x7pA-3v1zA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 MET A 288
TYR A 406
GLY A 405
GLY A 404
 None
 1.18A 5x7pA-4af1A:
undetectable		 5x7pA-4af1A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 TYR A  99
TYR A  79
GLY A  81
GLY A  82
 None
 1.06A 5x7pA-4bbwA:
2.1		 5x7pA-4bbwA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 MET B3103
TYR B2939
GLY B2938
GLY B2937
 None
 1.12A 5x7pA-4bedB:
undetectable		 5x7pA-4bedB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 TYR V 145
TYR V 146
GLY V 161
GLY V  60
 None
 1.10A 5x7pA-4bxsV:
undetectable		 5x7pA-4bxsV:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 TYR A 155
TYR A 166
GLY A 187
GLY A 193
 None
 1.15A 5x7pA-4cakA:
undetectable		 5x7pA-4cakA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA

(Arabidopsis
thaliana) 		PF03770
(IPK) 		4 MET A 224
TYR A 192
GLY A 193
GLY A 194
 None
 1.10A 5x7pA-4frfA:
undetectable		 5x7pA-4frfA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		4 MET A 135
TYR A  60
GLY A  59
GLY A  23
 None
 1.12A 5x7pA-4ha4A:
undetectable		 5x7pA-4ha4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is4 GLUTAMINE SYNTHETASE

(Medicago
truncatula) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 MET A 194
TYR A 150
GLY A 149
GLY A 148
 None
 1.03A 5x7pA-4is4A:
undetectable		 5x7pA-4is4A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  92
TYR L  28
GLY L  91
GLY L  90
 None
 1.22A 5x7pA-4jo2L:
undetectable		 5x7pA-4jo2L:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 MET A 208
TYR A 388
GLY A 201
GLY A 421
 None
 0.99A 5x7pA-4jrnA:
undetectable		 5x7pA-4jrnA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lms CRYPTOPHYTE
PHYCOCYANIN (ALPHA-1
CHAIN)
CRYPTOPHYTE
PHYCOCYANIN (BETA
CHAIN)

(Chroomonas sp.) 		PF00502
(Phycobilisome)
PF02972
(Phycoerythr_ab) 		4 TYR A  25
TYR B  18
GLY B  20
GLY B  21
 M1V  A 101 (-4.7A)
M1V  A 101 (-4.7A)
M1V  A 101 ( 3.7A)
M1V  A 101 ( 4.8A)
 1.16A 5x7pA-4lmsA:
undetectable		 5x7pA-4lmsA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 MET A 312
TYR A 236
GLY A 244
GLY A 245
 None
None
3AT  A 601 ( 4.7A)
3AT  A 601 ( 3.8A)
 0.92A 5x7pA-4lt6A:
undetectable		 5x7pA-4lt6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A 405
TYR A 404
GLY A 403
GLY A 402
 None
 0.71A 5x7pA-4mmoA:
undetectable		 5x7pA-4mmoA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozv ALGINATE LYASE

(Pseudomonas
aeruginosa) 		PF05426
(Alginate_lyase) 		4 MET A 122
TYR A 155
GLY A 153
GLY A 354
 None
 1.16A 5x7pA-4ozvA:
undetectable		 5x7pA-4ozvA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 MET A 271
TYR A 162
GLY A 161
GLY A 156
 GOL  A 703 ( 4.2A)
GOL  A 703 (-4.3A)
None
None
 1.14A 5x7pA-4pf1A:
undetectable		 5x7pA-4pf1A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py8 ANTIBODY 3.1 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR I  32
TYR I  53
GLY I 102
GLY I 101
 None
 1.11A 5x7pA-4py8I:
undetectable		 5x7pA-4py8I:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 TYR A1717
TYR A1732
GLY A1700
GLY A1698
 None
 1.08A 5x7pA-4uclA:
undetectable		 5x7pA-4uclA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli) 		PF01353
(GFP) 		4 TYR A  83
TYR A 182
GLY A 157
GLY A 156
 None
 1.20A 5x7pA-5bqlA:
undetectable		 5x7pA-5bqlA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		4 MET A 252
TYR A 298
TYR A 316
GLY A 297
 None
 1.19A 5x7pA-5cxpA:
undetectable		 5x7pA-5cxpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsc FAB HOU24.B LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  92
TYR B  28
GLY B  91
GLY B  90
 None
 1.18A 5x7pA-5dscB:
undetectable		 5x7pA-5dscB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 337
TYR A 348
GLY A 347
GLY A 346
 None
 0.96A 5x7pA-5e76A:
undetectable		 5x7pA-5e76A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo9 RIBITOL
2-DEHYDROGENASE

(Bradyrhizobium
japonicum) 		PF00106
(adh_short) 		4 MET A 108
TYR A 153
GLY A  94
GLY A  95
 None
SOR  A 302 (-3.9A)
None
None
 1.06A 5x7pA-5jo9A:
undetectable		 5x7pA-5jo9A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 MET A 260
TYR A 158
GLY A 174
GLY A  73
 None
 1.05A 5x7pA-5k8dA:
undetectable		 5x7pA-5k8dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 TYR A 533
TYR A 532
GLY A 549
GLY A 450
 None
 0.88A 5x7pA-5k8dA:
undetectable		 5x7pA-5k8dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 MET B1947
TYR B1837
GLY B1853
GLY B1760
 None
 1.21A 5x7pA-5k8dB:
undetectable		 5x7pA-5k8dB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwl VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 MET 3 166
TYR 3 189
GLY 3 188
GLY 3 187
 None
 1.19A 5x7pA-5kwl3:
undetectable		 5x7pA-5kwl3:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lac 3CL PROTEASE

(Alphamesonivirus
1) 		PF17222
(Peptidase_C107) 		4 MET A  15
TYR A 119
GLY A 155
GLY A 154
 None
 1.08A 5x7pA-5lacA:
undetectable		 5x7pA-5lacA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5low RABPHILIN-3A

(Rattus
norvegicus) 		PF00168
(C2) 		4 MET A 588
TYR A 550
GLY A 556
GLY A 555
 None
 1.07A 5x7pA-5lowA:
undetectable		 5x7pA-5lowA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 393
TYR A 394
GLY A 392
GLY A 389
 None
 1.05A 5x7pA-5lx8A:
undetectable		 5x7pA-5lx8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A  72
TYR A  73
GLY A 430
GLY A 428
 None
 1.09A 5x7pA-5n0cA:
undetectable		 5x7pA-5n0cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 MET A 268
TYR A 159
GLY A 175
GLY A  75
 None
 0.96A 5x7pA-5n4lA:
undetectable		 5x7pA-5n4lA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 MET A 962
TYR A 854
GLY A 870
GLY A 784
 None
 1.20A 5x7pA-5n4lA:
undetectable		 5x7pA-5n4lA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 MET A 302
TYR A 367
GLY A 466
GLY A 255
 None
 1.01A 5x7pA-5njfA:
undetectable		 5x7pA-5njfA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		4 MET A  18
TYR A  11
GLY A  80
GLY A  81
 None
 1.10A 5x7pA-5ugzA:
undetectable		 5x7pA-5ugzA:
12.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 TYR A 218
TYR A 230
GLY A 232
GLY A 233
 None
 0.12A 5x7pA-5x7sA:
59.0		 5x7pA-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 4 TYR A 240
TYR A 239
GLY A 238
GLY A 237
 None
 1.11A 5x7pA-5x8hA:
undetectable		 5x7pA-5x8hA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 TYR A 399
TYR A 385
GLY A 400
GLY A 583
 None
 1.17A 5x7pA-5xyaA:
undetectable		 5x7pA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 4 MET A 126
TYR A 161
TYR A 162
GLY A 163
 None
 0.87A 5x7pA-6b5vA:
undetectable		 5x7pA-6b5vA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 4 TYR L 312
TYR L 303
GLY L 302
GLY L 301
 None
 0.95A 5x7pA-6ehsL:
undetectable		 5x7pA-6ehsL:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus) 		no annotation 4 TYR 7 168
TYR 7 159
GLY 7 158
GLY 7 157
 None
 1.04A 5x7pA-6epd7:
undetectable		 5x7pA-6epd7:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 4 MET A 292
TYR A 207
GLY A 219
GLY A 220
 None
None
None
FAD  A 601 ( 4.0A)
 1.18A 5x7pA-6f72A:
undetectable		 5x7pA-6f72A:
5.26