SIMILAR PATTERNS OF AMINO ACIDS FOR 5X7P_A_ACRA1401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvp FLAVOPROTEIN 390

(Photobacterium
phosphoreum) 		no annotation 5 ASP A  97
ASP A  48
PHE A   9
ASN A  46
HIS A 131
 None
 1.46A 5x7pA-1fvpA:
undetectable		 5x7pA-1fvpA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		7 TRP A 318
ASP A 320
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.42A 5x7pA-2g3nA:
17.7		 5x7pA-2g3nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		7 TRP A 551
ASP A 553
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.37A 5x7pA-2x2iA:
25.7		 5x7pA-2x2iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		7 TRP A 580
ASP A 582
ARG A 642
TRP A 656
ASP A 659
PHE A 692
HIS A 740
 None
 0.57A 5x7pA-2xvgA:
33.6		 5x7pA-2xvgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 TRP A 580
TRP A 656
TRP A 343
PHE A 692
HIS A 740
 None
 0.91A 5x7pA-2xvgA:
33.6		 5x7pA-2xvgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		7 TRP A 441
ASP A 443
ARG A 526
TRP A 539
ASP A 542
PHE A 575
HIS A 600
 3CU  A1001 (-4.9A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.6A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
 0.50A 5x7pA-3cttA:
32.8		 5x7pA-3cttA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		7 TRP A 470
ASP A 472
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.59A 5x7pA-3lppA:
19.3		 5x7pA-3lppA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ARG A 404
TRP A 417
ASP A 420
PHE A 453
HIS A 478
 ACR  A 664 (-4.0A)
ACR  A 664 (-4.6A)
ACR  A 664 (-2.8A)
ACR  A 664 (-4.4A)
ACR  A 664 (-4.2A)
 0.42A 5x7pA-3pocA:
21.5		 5x7pA-3pocA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		7 TRP A1418
ASP A1420
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.53A 5x7pA-3topA:
24.7		 5x7pA-3topA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		7 TRP A 467
ASP A 469
ARG A 552
TRP A 565
ASP A 568
PHE A 601
HIS A 626
 None
ACR  A1001 (-3.2A)
ACR  A1001 (-3.0A)
ACR  A1001 (-4.8A)
ACR  A1001 (-2.7A)
ACR  A1001 (-4.3A)
ACR  A1001 (-4.1A)
 0.57A 5x7pA-3welA:
18.7		 5x7pA-3welA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		7 TRP A 410
ASP A 412
ARG A 463
TRP A 477
ASP A 480
PHE A 513
HIS A 540
 None
 0.40A 5x7pA-4b9yA:
21.5		 5x7pA-4b9yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 TRP A 319
ASP A 321
ARG A 385
ASP A 401
PHE A 434
 None
 1.16A 5x7pA-5djwA:
20.2		 5x7pA-5djwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		7 TRP A 554
ASP A 556
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.55A 5x7pA-5dkxA:
17.0		 5x7pA-5dkxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		6 ASP A 460
ARG A 507
TRP A 520
ASP A 523
PHE A 556
HIS A 588
 None
 0.42A 5x7pA-5f7cA:
13.2		 5x7pA-5f7cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		6 ASP A 467
ARG A 516
TRP A 529
ASP A 532
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
CA  A 805 ( 4.6A)
None
None
 0.62A 5x7pA-5f7sA:
21.4		 5x7pA-5f7sA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 ARG A 614
TRP A 627
ASP A 630
PHE A 663
HIS A 689
 GLC  A1116 (-2.8A)
GLC  A1117 (-4.6A)
GLC  A1117 (-2.7A)
GLC  A1116 (-4.6A)
GLC  A1117 (-4.1A)
 0.76A 5x7pA-5f7uA:
20.9		 5x7pA-5f7uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		7 TRP A 562
ASP A 564
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.55A 5x7pA-5hjrA:
34.4		 5x7pA-5hjrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		7 TRP A 551
ASP A 553
ARG A 613
TRP A 627
ASP A 630
PHE A 663
HIS A 709
 None
EDO  A1008 (-2.7A)
EDO  A1008 (-4.6A)
None
EDO  A1008 (-3.0A)
EDO  A1008 (-4.3A)
EDO  A1008 (-4.0A)
 0.46A 5x7pA-5jouA:
22.1		 5x7pA-5jouA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 TRP A 551
TRP A 627
TRP A 312
PHE A 663
HIS A 709
 None
None
None
EDO  A1008 (-4.3A)
EDO  A1008 (-4.0A)
 0.90A 5x7pA-5jouA:
22.1		 5x7pA-5jouA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 7 TRP A 516
ASP A 518
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
 None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.43A 5x7pA-5nn8A:
33.0		 5x7pA-5nn8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 5 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.74A 5x7pA-5x3jA:
21.9		 5x7pA-5x3jA:
6.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 ASP A 429
GLU A 430
ARG A 474
TRP A 488
ASN A 567
 None
 1.06A 5x7pA-5x7sA:
59.0		 5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		10 TRP A 427
ASP A 429
GLU A 430
ARG A 474
TRP A 488
ASP A 491
TRP A 504
PHE A 533
ASN A 534
HIS A 565
 None
 0.23A 5x7pA-5x7sA:
59.0		 5x7pA-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		5 GLN A  77
TYR A 146
ILE A  91
GLY A  55
SER A  56
 None
 1.46A 5x7pB-1wd3A:
2.8		 5x7pB-1wd3A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		5 GLN A 536
GLN A 493
ILE A 267
GLY A 559
SER A 558
 None
SIA  A1692 (-3.0A)
SIA  A1692 (-4.5A)
None
None
 1.31A 5x7pB-2bf6A:
0.9		 5x7pB-2bf6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 GLN A 136
TYR A 406
ILE A 427
GLY A 193
SER A 175
 None
 1.46A 5x7pB-2htvA:
0.0		 5x7pB-2htvA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 297
TYR A 125
ILE A 295
GLY A 133
SER A 132
 None
 1.40A 5x7pB-2vrkA:
1.3		 5x7pB-2vrkA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		5 GLN A  88
GLN A  80
ASP A 108
GLY A 193
SER A 190
 None
THM  A 302 (-3.0A)
THM  A 302 (-3.5A)
None
None
 1.47A 5x7pB-4ho4A:
0.4		 5x7pB-4ho4A:
12.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		9 GLN A 174
GLN A 194
TRP A 284
ASP A 311
TYR A 312
ILE A 354
LYS A 356
GLY A 437
SER A 438
 None
 0.39A 5x7pB-5x7sA:
58.3		 5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		6 GLN A 193
GLN A 194
TRP A 284
ASP A 311
TYR A 312
ILE A 354
 None
 1.47A 5x7pB-5x7sA:
58.3		 5x7pB-5x7sA:
100.00