SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_C_SAMC902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqb APO-D-ALANYL CARRIER
PROTEIN

(Lactobacillus
casei) 		PF00550
(PP-binding) 		5 LEU A  11
ALA A  15
GLU A  33
PHE A  32
THR A  69
 None
 1.25A 5x6yC-1hqbA:
undetectable		 5x6yC-1hqbA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A  25
GLY A 177
PRO A 220
PRO A 216
GLU A 161
 None
 1.29A 5x6yC-1ofeA:
1.2		 5x6yC-1ofeA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 5 LEU B   5
PRO B   7
ALA B   6
PRO B  10
THR B  28
 None
 1.11A 5x6yC-1pbyB:
undetectable		 5x6yC-1pbyB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		5 LEU A 188
PRO A 238
ALA A 237
GLU A 249
PHE A 247
 None
 1.23A 5x6yC-1pwwA:
undetectable		 5x6yC-1pwwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		5 GLY A 351
ALA A 542
HIS A 546
PRO A 534
THR A 350
 None
 1.04A 5x6yC-1q50A:
2.2		 5x6yC-1q50A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLY A 242
ASP A 266
LYS A 265
GLU A 259
THR A 243
 None
 1.24A 5x6yC-1qdlA:
undetectable		 5x6yC-1qdlA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 334
GLY A 310
ALA A 132
LYS A 115
THR A 308
 None
 1.23A 5x6yC-1uouA:
0.6		 5x6yC-1uouA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y89 DEVB PROTEIN

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 LEU A 137
GLY A 140
PRO A 214
ALA A 215
ASP A 142
 None
PO4  A 241 (-3.3A)
None
None
PO4  A 241 (-3.6A)
 1.24A 5x6yC-1y89A:
0.4		 5x6yC-1y89A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 GLY A  94
ALA A 167
HIS A 166
PRO A  84
THR A 116
 None
 1.22A 5x6yC-2bi3A:
undetectable		 5x6yC-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 LEU A 138
GLY A  94
ALA A 167
HIS A 166
PRO A  84
 None
 1.18A 5x6yC-2bi3A:
undetectable		 5x6yC-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A  10
ALA A  16
ASP A  33
GLU A 218
PHE A 219
 FAD  A1385 (-3.1A)
None
FAD  A1385 (-2.7A)
None
None
 1.09A 5x6yC-2bi7A:
1.1		 5x6yC-2bi7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 LEU A 179
PRO A 275
ALA A 184
GLU A 260
PHE A 252
 None
 1.03A 5x6yC-2dulA:
3.8		 5x6yC-2dulA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		5 LEU A  65
GLY A 117
ALA A  61
PRO A 142
PHE A 120
 None
 1.16A 5x6yC-2fukA:
2.0		 5x6yC-2fukA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF03480
(DctP) 		5 GLY A 214
ALA A 206
ASP A 213
PHE A 159
THR A 161
 None
 1.29A 5x6yC-2hpgA:
0.1		 5x6yC-2hpgA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		5 LEU A 179
TYR A 195
GLY A 197
ASP A 224
PRO A 225
 None
 0.37A 5x6yC-2jh9A:
15.8		 5x6yC-2jh9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8w DESIGNED PROTEIN
DA05R1

(synthetic
construct) 		no annotation 5 LEU A  71
GLY A  32
ALA A  74
GLU A   9
PHE A   8
 None
 1.24A 5x6yC-2n8wA:
undetectable		 5x6yC-2n8wA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 GLY A 352
ALA A 544
HIS A 548
PRO A 536
THR A 351
 None
 1.08A 5x6yC-2o2cA:
2.5		 5x6yC-2o2cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 LEU A 272
TYR A 302
GLY A 301
ALA A 268
GLU A 291
 ALY  A 275 (-4.8A)
ALY  A 275 ( 4.8A)
None
ALY  A 275 ( 4.1A)
None
 1.25A 5x6yC-2ou2A:
undetectable		 5x6yC-2ou2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		5 GLY B 261
ASP B 287
GLU B 290
PHE B 292
THR B 259
 None
 1.23A 5x6yC-2pffB:
undetectable		 5x6yC-2pffB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		5 GLY A  30
PRO A  33
ASP A  55
LYS A  57
GLU A  71
 SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.2A)
SAM  A 203 (-4.9A)
 0.69A 5x6yC-2plwA:
undetectable		 5x6yC-2plwA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 150
GLY A 116
ALA A 151
PHE A 255
THR A 115
 None
None
None
FAD  A 400 (-3.6A)
None
 1.31A 5x6yC-2qdxA:
undetectable		 5x6yC-2qdxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 LEU A 421
TYR A 255
ALA A 392
GLU A 377
PHE A 379
 None
 1.23A 5x6yC-2r9hA:
undetectable		 5x6yC-2r9hA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		6 LEU A  42
TYR A  66
GLY A  68
PRO A  71
HIS A  74
ASP A  95
 SAH  A 400 (-4.7A)
SAH  A 400 (-4.6A)
SAH  A 400 (-3.4A)
SAH  A 400 (-3.7A)
SAH  A 400 (-3.9A)
SAH  A 400 (-2.6A)
 0.58A 5x6yC-2vp3A:
12.5		 5x6yC-2vp3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 GLY A 244
PRO A 239
ALA A 238
PHE A 291
THR A 286
 None
 1.32A 5x6yC-2w9mA:
undetectable		 5x6yC-2w9mA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waw MOBA RELATE PROTEIN

(Mycobacterium
sp. DSM 3803) 		PF12804
(NTP_transf_3) 		5 LEU A  53
GLY A 104
ALA A  13
ASP A 105
THR A  37
 None
 1.36A 5x6yC-2wawA:
undetectable		 5x6yC-2wawA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A  76
GLY A 247
ALA A 208
PRO A 318
GLU A 316
 None
None
None
None
ZN  A1673 ( 4.5A)
 1.25A 5x6yC-2xpzA:
undetectable		 5x6yC-2xpzA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 GLY A 609
PRO A 603
ASP A 161
PRO A 160
GLU A 595
 None
 1.26A 5x6yC-2xvgA:
undetectable		 5x6yC-2xvgA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 LEU A 271
TYR A 301
GLY A 300
ALA A 267
GLU A 290
 ALY  A 274 (-4.3A)
ALY  A 274 ( 4.8A)
None
ALY  A 274 ( 4.0A)
None
 1.04A 5x6yC-2y0mA:
undetectable		 5x6yC-2y0mA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01135
(PCMT) 		5 PRO A  51
ALA A  62
HIS A  64
GLU A 109
THR A 153
 None
 1.31A 5x6yC-2yxeA:
undetectable		 5x6yC-2yxeA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		6 TYR A 220
GLY A 223
ALA A 201
HIS A 199
PRO A 214
THR A 224
 None
 1.19A 5x6yC-2yzwA:
undetectable		 5x6yC-2yzwA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE

(Pseudomonas
putida) 		PF00202
(Aminotran_3) 		5 LEU X 345
GLY X 264
GLU X 226
PHE X 258
THR X 263
 None
None
PLP  X 450 (-4.0A)
None
None
 1.20A 5x6yC-3a8uX:
undetectable		 5x6yC-3a8uX:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 LEU A  55
ASP A 321
PRO A 289
PHE A 286
THR A 325
 None
 1.29A 5x6yC-3bc8A:
undetectable		 5x6yC-3bc8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLY A 383
ALA A1015
ASP A 384
GLU A 419
THR A 382
 None
 1.18A 5x6yC-3dy5A:
undetectable		 5x6yC-3dy5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 408
PRO A 280
ALA A 279
ASP A 273
THR A 409
 None
 1.16A 5x6yC-3e60A:
undetectable		 5x6yC-3e60A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ex7 RNA-BINDING PROTEIN
8A

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU B 104
GLY B  79
ALA B  84
PRO B 143
THR B  78
 None
 1.34A 5x6yC-3ex7B:
undetectable		 5x6yC-3ex7B:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLY A 383
ALA A1015
ASP A 384
GLU A 419
THR A 382
 GOL  A2305 (-3.4A)
GOL  A2305 (-3.6A)
GOL  A2305 (-3.9A)
None
None
 1.35A 5x6yC-3fg4A:
undetectable		 5x6yC-3fg4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		5 LEU A 241
TYR A  81
GLY A  11
PRO A  15
THR A  12
 None
 1.34A 5x6yC-3hc7A:
undetectable		 5x6yC-3hc7A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 GLY A 125
ALA A 131
ASP A 150
PRO A 151
THR A 188
 None
 0.88A 5x6yC-3hdjA:
4.3		 5x6yC-3hdjA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 LEU A 158
TYR A 181
ASP A  14
PRO A  68
GLU A  71
 None
 1.36A 5x6yC-3hs0A:
undetectable		 5x6yC-3hs0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 GLY A 742
PRO A 775
ASP A 769
PRO A 770
LYS A 771
 None
 1.13A 5x6yC-3ihyA:
undetectable		 5x6yC-3ihyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF) 		5 LEU C 188
PRO C 238
ALA C 237
GLU C 249
PHE C 247
 None
 1.34A 5x6yC-3kwvC:
undetectable		 5x6yC-3kwvC:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 408
PRO A 280
ALA A 279
ASP A 273
THR A 409
 None
 1.06A 5x6yC-3kzuA:
undetectable		 5x6yC-3kzuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llv EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Archaeoglobus
fulgidus) 		PF02254
(TrkA_N) 		5 LEU A  21
GLY A  78
ALA A  17
GLU A  82
PHE A  83
 None
None
PO4  A 142 (-3.0A)
None
None
 1.26A 5x6yC-3llvA:
undetectable		 5x6yC-3llvA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		5 LEU A 133
GLY A 169
ALA A 134
GLU A  28
THR A  22
 None
 1.21A 5x6yC-3lmaA:
undetectable		 5x6yC-3lmaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 5 GLY A 435
PRO A 409
ALA A 410
ASP A 407
THR A 433
 None
 1.14A 5x6yC-3nlcA:
undetectable		 5x6yC-3nlcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 390
GLY A 197
PRO A 364
ASP A 193
THR A 198
 None
 1.22A 5x6yC-3nv9A:
undetectable		 5x6yC-3nv9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 LEU A 354
GLY A 411
ASP A 410
GLU A  27
THR A 414
 None
 1.23A 5x6yC-3pplA:
undetectable		 5x6yC-3pplA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 143
GLY A 330
ALA A 142
PRO A 306
GLU A 308
 None
 1.24A 5x6yC-3pzrA:
4.0		 5x6yC-3pzrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		5 LEU A 151
GLY A 130
ALA A 156
ASP A 127
PHE A 120
 None
 1.27A 5x6yC-3re2A:
undetectable		 5x6yC-3re2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 LEU A 118
GLY A  58
ALA A 111
PRO A  24
THR A  20
 None
 1.34A 5x6yC-3rrvA:
undetectable		 5x6yC-3rrvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A  38
GLY A  44
ALA A  40
ASP A  43
THR A  57
 ANP  A 401 (-4.3A)
None
GOL  A 414 (-3.4A)
MG  A 404 ( 3.1A)
None
 1.23A 5x6yC-3wjpA:
undetectable		 5x6yC-3wjpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 GLY A 135
HIS A 122
ASP A  83
GLU A  92
THR A 136
 None
 1.28A 5x6yC-3wn6A:
undetectable		 5x6yC-3wn6A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 390
GLY A 114
ALA A 174
PRO A 141
PHE A 166
 None
None
None
CO8  A1446 ( 4.4A)
CO8  A1446 (-4.2A)
 1.25A 5x6yC-4a0sA:
2.5		 5x6yC-4a0sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE

(Xanthomonas
citri) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 151
GLY A 117
ALA A 152
PHE A 256
THR A 116
 None
None
None
FAD  A1260 (-3.7A)
None
 1.34A 5x6yC-4b4dA:
undetectable		 5x6yC-4b4dA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 LEU A 352
GLY B 327
ALA A 323
GLU B 476
PHE A 669
 None
 1.05A 5x6yC-4cakA:
undetectable		 5x6yC-4cakA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY A 295
PRO A 278
ASP A 294
PHE A 260
THR A 298
 None
 1.36A 5x6yC-4dibA:
undetectable		 5x6yC-4dibA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4do7 AMIDOHYDROLASE 2

(Burkholderia
multivorans) 		PF04909
(Amidohydro_2) 		5 ALA A 117
ASP A 149
PRO A 148
GLU A 144
PHE A 143
 None
 1.00A 5x6yC-4do7A:
undetectable		 5x6yC-4do7A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 LEU A  75
GLY A   7
ALA A  51
PHE A 128
THR A  30
 None
 1.20A 5x6yC-4e69A:
undetectable		 5x6yC-4e69A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 GLY C 199
PRO C 176
ALA C 175
GLU C 202
PHE C 201
 None
 1.32A 5x6yC-4fl4C:
undetectable		 5x6yC-4fl4C:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		5 LEU A 323
TYR A 345
GLY A 346
PRO A 341
GLU A 275
 None
 1.25A 5x6yC-4gdnA:
undetectable		 5x6yC-4gdnA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 5 GLY A 234
PRO A 191
ALA A 192
PRO A 212
GLU A 214
 None
 1.30A 5x6yC-4i4nA:
undetectable		 5x6yC-4i4nA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 416
PRO A 287
ALA A 286
ASP A 280
THR A 417
 None
 1.14A 5x6yC-4jgaA:
undetectable		 5x6yC-4jgaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 GLY A 331
PRO A 325
ALA A  74
ASP A 327
THR A 315
 None
 1.30A 5x6yC-4m38A:
undetectable		 5x6yC-4m38A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		5 GLY B 213
PRO B 211
HIS A 410
ASP B 151
PHE B 182
 None
CA  B 705 (-4.7A)
None
CA  B 705 (-3.4A)
None
 1.16A 5x6yC-4nenB:
undetectable		 5x6yC-4nenB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 LEU A 145
GLY A 247
PRO A 527
ALA A 260
GLU A 538
 None
 1.27A 5x6yC-4nurA:
undetectable		 5x6yC-4nurA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 437
PRO A 297
ALA A 296
ASP A 287
THR A 438
 None
 1.20A 5x6yC-4oqjA:
undetectable		 5x6yC-4oqjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		5 GLY A 353
ALA A 545
HIS A 549
PRO A 537
THR A 352
 None
 1.07A 5x6yC-4qfhA:
undetectable		 5x6yC-4qfhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		5 TYR A 356
HIS A  81
ASP A 324
PRO A 319
GLU A 285
 None
None
None
None
4VP  A 601 (-2.3A)
 1.22A 5x6yC-4s13A:
undetectable		 5x6yC-4s13A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 249
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.12A 5x6yC-4tmcA:
undetectable		 5x6yC-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 293
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.27A 5x6yC-4tmcA:
undetectable		 5x6yC-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 434
PRO A 297
ALA A 296
ASP A 287
THR A 435
 None
 1.22A 5x6yC-4wkyA:
undetectable		 5x6yC-4wkyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 LEU A  98
GLY A 114
PRO A 183
PHE A 178
THR A 115
 None
None
None
X9X  A 401 ( 4.6A)
None
 1.33A 5x6yC-4wt7A:
2.7		 5x6yC-4wt7A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 349
ALA A 311
PRO A 283
GLU A 284
THR A 332
 None
None
NAG  A2004 (-4.3A)
None
None
 1.28A 5x6yC-4xwhA:
undetectable		 5x6yC-4xwhA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis) 		PF04255
(DUF433) 		5 LEU A  18
GLY A  72
ALA A  21
PHE A  11
THR A  56
 None
 1.28A 5x6yC-5af3A:
undetectable		 5x6yC-5af3A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 TYR A 341
GLY A 305
PRO A 302
ASP A 308
GLU A 290
 None
None
None
None
TRS  A 902 ( 4.1A)
 1.30A 5x6yC-5bwdA:
undetectable		 5x6yC-5bwdA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 177
GLY A 156
ALA A 182
ASP A 153
PHE A 146
 59Q  A 601 (-3.8A)
None
59Q  A 601 (-3.7A)
None
None
 1.28A 5x6yC-5ddbA:
undetectable		 5x6yC-5ddbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 GLY A 130
ASP A 153
PRO A 155
LYS A 156
THR A 182
 NAD  A 401 (-3.6A)
NAD  A 401 (-2.3A)
NAD  A 401 ( 4.5A)
NAD  A 401 (-4.7A)
NAD  A 401 (-4.5A)
 0.99A 5x6yC-5dt9A:
3.5		 5x6yC-5dt9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 GLY B 213
PRO B 211
HIS A 404
ASP B 151
PHE B 182
 None
None
None
CA  B2003 (-3.4A)
None
 1.10A 5x6yC-5e6sB:
undetectable		 5x6yC-5e6sB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 5 GLY C 426
PRO C 288
ALA C 287
ASP C 278
THR C 427
 None
 1.14A 5x6yC-5elpC:
undetectable		 5x6yC-5elpC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 LEU A 477
GLY A  92
ALA A 476
ASP A  42
PRO A  43
 None
 1.30A 5x6yC-5fxeA:
undetectable		 5x6yC-5fxeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqq HEME-BINDING PROTEIN
2

(Homo sapiens) 		PF04832
(SOUL) 		5 TYR A 110
GLY A  24
PRO A  45
ALA A  46
GLU A  39
 None
 1.26A 5x6yC-5gqqA:
undetectable		 5x6yC-5gqqA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		5 LEU A 378
GLY A 426
PRO A 380
ALA A 379
PRO A 385
 None
 1.29A 5x6yC-5h6sA:
undetectable		 5x6yC-5h6sA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 386
GLY A 106
ASP A 107
PHE A 104
THR A 109
 None
 1.32A 5x6yC-5h7kA:
undetectable		 5x6yC-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 5 LEU B1081
GLY B1145
ASP B1144
GLU B1141
PHE B1142
 None
 1.01A 5x6yC-5hb0B:
undetectable		 5x6yC-5hb0B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		5 LEU A 140
PRO A 138
ALA A 139
ASP A 136
PHE A  59
 None
None
None
None
V55  A 503 (-3.4A)
 1.22A 5x6yC-5j55A:
undetectable		 5x6yC-5j55A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 LEU A  35
GLY A 480
ALA A  17
PRO A 415
THR A 479
 None
 1.32A 5x6yC-5jjhA:
undetectable		 5x6yC-5jjhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 LEU B 705
GLY B 710
PRO B 648
ALA B 649
THR B 711
 None
 1.28A 5x6yC-5ldrB:
undetectable		 5x6yC-5ldrB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 5 LEU A  84
GLY A  61
PRO A  70
GLU A  65
PHE A  63
 None
 1.13A 5x6yC-5oshA:
undetectable		 5x6yC-5oshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thx FERREDOXIN--NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 150
GLY A 116
ALA A 151
PHE A 255
THR A 115
 None
NAP  A 301 ( 3.9A)
None
FAD  A 303 (-3.4A)
NAP  A 301 (-3.5A)
 1.33A 5x6yC-5thxA:
undetectable		 5x6yC-5thxA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		5 GLY A  73
PRO A  76
ALA A  77
ASP A  74
LYS A 131
 None
 1.14A 5x6yC-5tkfA:
undetectable		 5x6yC-5tkfA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9z PHOSPHOGLYCEROL
TRANSFERASE

(Streptococcus
pyogenes) 		no annotation 5 LEU A 683
GLY A 710
PRO A 714
ASP A 711
GLU A 534
 None
None
None
MN  A 901 (-2.6A)
None
 1.34A 5x6yC-5u9zA:
undetectable		 5x6yC-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 5 LEU A 110
GLY A 115
ALA A 134
GLU A 325
PHE A 324
 None
 1.31A 5x6yC-5v2mA:
undetectable		 5x6yC-5v2mA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve6 TYROSINE-PROTEIN
KINASE SGK223

(Homo sapiens) 		no annotation 5 LEU A1287
TYR A1262
ALA A1304
HIS A1305
GLU A1149
 None
 1.29A 5x6yC-5ve6A:
undetectable		 5x6yC-5ve6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 LEU C 269
TYR C 285
GLY C 287
GLU C 333
PHE C 307
 None
 1.35A 5x6yC-5x6xC:
53.1		 5x6yC-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 11 LEU C 269
TYR C 285
GLY C 287
PRO C 290
ALA C 291
HIS C 293
ASP C 308
PRO C 309
GLU C 333
PHE C 334
THR C 360
 None
 0.49A 5x6yC-5x6xC:
53.1		 5x6yC-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 11 LEU C 269
TYR C 285
GLY C 287
PRO C 290
ALA C 291
HIS C 293
ASP C 308
PRO C 309
LYS C 310
PHE C 334
THR C 360
 None
 0.42A 5x6yC-5x6xC:
53.1		 5x6yC-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 383
GLY A 630
ALA A 323
PRO A 564
THR A 629
 None
 1.34A 5x6yC-5x9wA:
2.2		 5x6yC-5x9wA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 LEU D 904
GLY D 880
ALA D 919
GLU D 837
THR D 881
 None
 1.13A 5x6yC-5xbkD:
undetectable		 5x6yC-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 GLY A 289
ALA A 292
ASP A 160
PRO A 161
THR A 288
 None
 1.35A 5x6yC-6c49A:
undetectable		 5x6yC-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 5 LEU A 290
GLY A 255
ALA A 289
GLU A 198
THR A 253
 None
None
None
None
PLP  A 601 ( 4.1A)
 1.29A 5x6yC-6enzA:
undetectable		 5x6yC-6enzA:
undetectable