SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_C_SAMC901
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dts | DETHIOBIOTINSYNTHETASE (Escherichiacoli) |
PF13500(AAA_26) | 5 | GLY A 35ASP A 110ALA A 109SER A 62LEU A 64 | None | 1.08A | 5x6yC-1dtsA:2.6 | 5x6yC-1dtsA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I BETASUBUNIT (Methanopyruskandleri) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | VAL B 348GLY B 347GLU B 340ALA B 353LEU B 311 | None | 1.25A | 5x6yC-1e6vB:undetectable | 5x6yC-1e6vB:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 6 | VAL A 15GLY A 16GLU A 39LYS A 40ALA A 119ASN A 277 | NoneFAD A 462 (-3.4A)FAD A 462 (-2.5A)FAD A 462 (-4.1A)FAD A 462 (-4.0A)None | 0.86A | 5x6yC-1ebdA:undetectable | 5x6yC-1ebdA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggv | DIENELACTONEHYDROLASE (Pseudomonasputida) |
PF01738(DLH) | 5 | VAL A 147GLY A 148GLU A 150SER A 178ASP A 171 | SEB A 123 ( 4.3A)NoneNoneNoneNone | 1.15A | 5x6yC-1ggvA:2.1 | 5x6yC-1ggvA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h81 | POLYAMINE OXIDASE (Zea mays) |
PF01593(Amino_oxidase) | 5 | VAL A 270GLY A 269ASP A 396SER A 273LEU A 275 | FAD A 579 ( 4.9A)NoneNoneNoneFAD A 579 (-4.5A) | 1.23A | 5x6yC-1h81A:undetectable | 5x6yC-1h81A:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i8t | UDP-GALACTOPYRANOSEMUTASE (Escherichiacoli) |
PF03275(GLF)PF13450(NAD_binding_8) | 5 | VAL A 7GLY A 8GLU A 31LYS A 32ASP A 212 | FAD A 450 (-4.7A)FAD A 450 (-3.2A)FAD A 450 (-2.8A)FAD A 450 (-3.8A)FAD A 450 (-3.5A) | 0.51A | 5x6yC-1i8tA:undetectable | 5x6yC-1i8tA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iah | TRANSIENT RECEPTORPOTENTIAL-RELATEDPROTEIN (Mus musculus) |
PF02816(Alpha_kinase) | 5 | GLY A1792GLU A1672LEU A1796ASN A1795ASN A1731 | None | 1.06A | 5x6yC-1iahA:undetectable | 5x6yC-1iahA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iah | TRANSIENT RECEPTORPOTENTIAL-RELATEDPROTEIN (Mus musculus) |
PF02816(Alpha_kinase) | 5 | VAL A1790GLY A1792LEU A1796ASN A1795ASN A1731 | None | 1.08A | 5x6yC-1iahA:undetectable | 5x6yC-1iahA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jg3 | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Pyrococcusfuriosus) |
PF01135(PCMT) | 5 | VAL A 98GLY A 99GLU A 121ASP A 148LEU A 221 | NoneADN A 500 (-3.2A)ADN A 500 (-2.9A)ADN A 500 (-3.7A)ADN A 500 (-4.2A) | 1.01A | 5x6yC-1jg3A:4.7 | 5x6yC-1jg3A:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | VAL A 69GLY A 68ALA A 538SER A 65LEU A 63 | None | 1.11A | 5x6yC-1kb0A:undetectable | 5x6yC-1kb0A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | VAL A 69GLY A 540ALA A 538SER A 65LEU A 63 | None | 1.19A | 5x6yC-1kb0A:undetectable | 5x6yC-1kb0A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l7b | DNA LIGASE (Thermusthermophilus) |
PF00533(BRCT) | 5 | VAL A 50GLY A 51SER A 20ALA A 61ASN A 53 | None | 1.14A | 5x6yC-1l7bA:undetectable | 5x6yC-1l7bA:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjf | SPERMIDINE SYNTHASE (Pyrococcusfuriosus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 82GLU A 104ASP A 141SER A 159LEU A 169 | None | 0.98A | 5x6yC-1mjfA:6.9 | 5x6yC-1mjfA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nu5 | CHLOROMUCONATECYCLOISOMERASE (Pseudomonas sp.P51) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 356GLY A 355SER A 119ALA A 306LEU A 339 | None | 1.20A | 5x6yC-1nu5A:undetectable | 5x6yC-1nu5A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1onf | GLUTATHIONEREDUCTASE (Plasmodiumfalciparum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 8GLU A 31LYS A 32SER A 33ALA A 110 | FAD A 500 (-2.8A)FAD A 500 (-2.6A)FAD A 500 (-3.3A)FAD A 500 ( 4.0A)FAD A 500 (-3.3A) | 0.74A | 5x6yC-1onfA:undetectable | 5x6yC-1onfA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p8r | ARGINASE 1 (Rattusnorvegicus) |
PF00491(Arginase) | 5 | VAL A 96ALA A 13SER A 107LEU A 80ASN A 77 | None | 1.06A | 5x6yC-1p8rA:4.5 | 5x6yC-1p8rA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnl | ALIPHATIC AMIDASEEXPRESSION-REGULATING PROTEIN (Pseudomonasaeruginosa) |
PF13433(Peripla_BP_5) | 5 | VAL A 206GLY A 207GLU A 238SER A 235ASN A 106 | NoneNoneNoneNoneBMD A1001 ( 4.0A) | 1.18A | 5x6yC-1qnlA:3.2 | 5x6yC-1qnlA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjw | ALCOHOLDEHYDROGENASE (Geobacillusstearothermophilus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 28GLY A 71ASP A 129ALA A 128LEU A 77 | None | 1.24A | 5x6yC-1rjwA:2.4 | 5x6yC-1rjwA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhc | NADH OXIDASE/NITRITE REDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2) | 5 | VAL A 6GLY A 7ALA A 75LEU A 230ASN A 227 | NoneFAD A 360 (-3.2A)FAD A 360 (-3.6A)FAD A 360 ( 4.3A)None | 1.02A | 5x6yC-1xhcA:undetectable | 5x6yC-1xhcA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhc | NADH OXIDASE/NITRITE REDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2) | 5 | VAL A 6GLY A 7LYS A 30ALA A 75ASN A 227 | NoneFAD A 360 (-3.2A)FAD A 360 (-4.7A)FAD A 360 (-3.6A)None | 1.05A | 5x6yC-1xhcA:undetectable | 5x6yC-1xhcA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y6z | HEAT SHOCK PROTEIN,PUTATIVE (Plasmodiumfalciparum) |
PF00183(HSP90) | 5 | VAL A 160ALA A 171SER A 243LEU A 244ASN A 247 | None | 1.19A | 5x6yC-1y6zA:undetectable | 5x6yC-1y6zA:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1q | LUCIFERIN4-MONOOXYGENASE (Luciolacruciata) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | VAL A 325GLY A 326SER A 316SER A 322LEU A 461 | None | 1.16A | 5x6yC-2d1qA:4.4 | 5x6yC-2d1qA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fca | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Bacillussubtilis) |
PF02390(Methyltransf_4) | 5 | VAL A 45GLY A 46GLU A 69ASP A 96ALA A 97 | None K A 250 (-3.9A)NoneNoneNone | 1.03A | 5x6yC-2fcaA:2.4 | 5x6yC-2fcaA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gko | MICROBIAL SERINEPROTEINASES SUBTILISIN (Bacillussubtilis) |
PF00082(Peptidase_S8) | 5 | VAL A 37GLY A 72SER A 138ALA A 100LEU A 98 | None | 1.23A | 5x6yC-2gkoA:undetectable | 5x6yC-2gkoA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 5 | VAL A 41GLY A 42GLU A 71ALA A 167LEU A 219 | FAD A 611 (-4.9A)FAD A 611 (-3.3A)FAD A 611 (-2.9A)FAD A 611 (-3.3A)FAD A 611 (-4.4A) | 0.65A | 5x6yC-2gmhA:undetectable | 5x6yC-2gmhA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hs5 | PUTATIVETRANSCRIPTIONALREGULATOR GNTR (Rhodococcusjostii) |
PF00392(GntR)PF07729(FCD) | 5 | VAL A 144GLY A 145ALA A 132LEU A 193ASN A 196 | None | 0.94A | 5x6yC-2hs5A:undetectable | 5x6yC-2hs5A:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLU A 147ASP A 178ALA A 179SER A 197LEU A 207 | S4M A 501 (-2.7A)S4M A 501 (-3.3A)S4M A 501 (-3.5A)NoneS4M A 501 (-4.4A) | 1.11A | 5x6yC-2pt6A:8.0 | 5x6yC-2pt6A:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 6 | VAL A 123GLY A 124GLU A 147ASP A 178ALA A 179LEU A 207 | NoneS4M A 501 (-3.4A)S4M A 501 (-2.7A)S4M A 501 (-3.3A)S4M A 501 (-3.5A)S4M A 501 (-4.4A) | 0.79A | 5x6yC-2pt6A:8.0 | 5x6yC-2pt6A:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9z | GLUTATHIONE AMIDEREDUCTASE (Marichromatiumgracile) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 11GLU A 34ALA A 114LEU A 269ASN A 265 | FAD A 500 (-3.1A)FAD A 500 (-2.7A)FAD A 500 (-3.8A)FAD A 500 (-4.6A)FAD A 500 ( 4.7A) | 1.09A | 5x6yC-2r9zA:undetectable | 5x6yC-2r9zA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpq | ACETYL-COACARBOXYLASE (Staphylococcusaureus) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | VAL A 366GLY A 365GLU A 393ALA A 406LEU A 389 | None | 1.24A | 5x6yC-2vpqA:2.3 | 5x6yC-2vpqA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bus | METHYLTRANSFERASE (Lechevalieriaaerocolonigenes) |
PF08241(Methyltransf_11) | 5 | VAL A 68GLY A 69ASP A 119ALA A 120SER A 138 | NoneSAH A 274 (-3.1A)SAH A 274 (-3.6A)SAH A 274 (-3.5A)None | 0.76A | 5x6yC-3busA:5.9 | 5x6yC-3busA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgx | PUTATIVENUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE (Desulfovibrioalaskensis) |
PF09837(DUF2064) | 5 | VAL A 105SER A 2ASP A 100ALA A 97LEU A 7 | None | 1.09A | 5x6yC-3cgxA:undetectable | 5x6yC-3cgxA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed4 | ARYLSULFATASE (Escherichiacoli) |
PF00884(Sulfatase) | 5 | GLY A 212GLU A 240ASP A 293ALA A 294SER A 216 | None | 1.03A | 5x6yC-3ed4A:2.7 | 5x6yC-3ed4A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fut | DIMETHYLADENOSINETRANSFERASE (Thermusthermophilus) |
PF00398(RrnaAD) | 7 | VAL A 53GLY A 54GLU A 75LYS A 76ASP A 99ALA A 100LEU A 126 | None | 0.88A | 5x6yC-3futA:4.3 | 5x6yC-3futA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fut | DIMETHYLADENOSINETRANSFERASE (Thermusthermophilus) |
PF00398(RrnaAD) | 5 | VAL A 53GLY A 54GLU A 75LYS A 76LEU A 118 | None | 0.90A | 5x6yC-3futA:4.3 | 5x6yC-3futA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fwz | INNER MEMBRANEPROTEIN YBAL (Escherichiacoli) |
PF02254(TrkA_N) | 5 | VAL A 423GLY A 424GLU A 447ALA A 468LEU A 487 | AMP A 601 ( 4.9A)AMP A 601 (-3.5A)AMP A 601 (-2.8A)AMP A 601 (-3.9A)None | 1.23A | 5x6yC-3fwzA:3.1 | 5x6yC-3fwzA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fwz | INNER MEMBRANEPROTEIN YBAL (Escherichiacoli) |
PF02254(TrkA_N) | 5 | VAL A 423GLY A 424GLU A 447SER A 449ALA A 468 | AMP A 601 ( 4.9A)AMP A 601 (-3.5A)AMP A 601 (-2.8A)NoneAMP A 601 (-3.9A) | 0.90A | 5x6yC-3fwzA:3.1 | 5x6yC-3fwzA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g85 | TRANSCRIPTIONALREGULATOR (LACIFAMILY) (Clostridiumacetobutylicum) |
PF13377(Peripla_BP_3) | 5 | VAL A 257GLY A 256ALA A 233LEU A 261ASN A 262 | None | 1.12A | 5x6yC-3g85A:undetectable | 5x6yC-3g85A:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2b | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 5 | VAL A 105GLY A 106GLU A 127SER A 168LEU A 169 | NoneSAH A 301 (-3.4A)SAH A 301 (-2.6A)SAH A 301 (-4.7A)None | 1.16A | 5x6yC-3h2bA:7.2 | 5x6yC-3h2bA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i04 | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT BETA (Moorellathermoacetica) |
PF03063(Prismane) | 5 | VAL A 331GLY A 314ALA A 340LEU A 271ASN A 311 | None | 1.23A | 5x6yC-3i04A:2.2 | 5x6yC-3i04A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ks7 | PUTATIVE PUTATIVEPNGASE F (Bacteroidesfragilis) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 5 | VAL A 106LYS A 109SER A 110ALA A 203LEU A 199 | None | 1.25A | 5x6yC-3ks7A:undetectable | 5x6yC-3ks7A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljp | CHOLINE OXIDASE (Arthrobacterglobiformis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | VAL A 19GLY A 20GLU A 44ALA A 232LEU A 277 | NoneFDA A 547 (-3.2A)FDA A 547 (-2.7A)FDA A 547 (-3.6A)None | 0.75A | 5x6yC-3ljpA:undetectable | 5x6yC-3ljpA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lqy | PUTATIVEISOCHORISMATASEHYDROLASE (Oleispiraantarctica) |
PF00857(Isochorismatase) | 5 | VAL A 118GLY A 119ASP A 145ALA A 143LEU A 42 | None | 0.99A | 5x6yC-3lqyA:undetectable | 5x6yC-3lqyA:12.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moi | PROBABLEDEHYDROGENASE (Bordetellabronchiseptica) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | VAL A 142GLY A 143GLU A 308ALA A 310LEU A 312 | None | 1.09A | 5x6yC-3moiA:2.0 | 5x6yC-3moiA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swh | PROTEIN UNC-13HOMOLOG A (Rattusnorvegicus) |
PF10540(Membr_traf_MHD) | 5 | VAL A1264ASP A1184LEU A1268ASN A1270ASN A1271 | None | 1.03A | 5x6yC-3swhA:undetectable | 5x6yC-3swhA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbh | O-ACETYL SERINESULFHYDRYLASE (Leishmaniadonovani) |
PF00291(PALP) | 5 | VAL A 185GLY A 186SER A 274ALA A 209LEU A 191 | LLP A 51 ( 4.2A)LLP A 51 ( 3.5A)LLP A 51 ( 2.6A)NoneNone | 1.21A | 5x6yC-3tbhA:3.0 | 5x6yC-3tbhA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqs | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE A (Coxiellaburnetii) |
PF00398(RrnaAD) | 5 | GLY A 40GLU A 61ASP A 86ALA A 87LEU A 115 | None | 0.89A | 5x6yC-3tqsA:4.5 | 5x6yC-3tqsA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uzu | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE A (Burkholderiapseudomallei) |
PF00398(RrnaAD) | 5 | GLY A 46GLU A 71ASP A 94ALA A 95LEU A 126 | None | 0.97A | 5x6yC-3uzuA:4.4 | 5x6yC-3uzuA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va8 | PROBABLE DEHYDRATASE (Fusariumgraminearum) |
PF13378(MR_MLE_C) | 5 | VAL A 381GLY A 380SER A 132ALA A 329LEU A 364 | None | 1.16A | 5x6yC-3va8A:undetectable | 5x6yC-3va8A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vyw | MNMC2 (Aquifexaeolicus) |
PF05430(Methyltransf_30) | 5 | GLU A 133LYS A 134ASP A 174ALA A 175LEU A 203 | SAM A 501 (-2.3A)SAM A 501 (-4.4A)SAM A 501 (-3.4A)SAM A 501 (-3.8A)SAM A 501 (-4.6A) | 0.87A | 5x6yC-3vywA:6.0 | 5x6yC-3vywA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vyw | MNMC2 (Aquifexaeolicus) |
PF05430(Methyltransf_30) | 5 | GLY A 104GLU A 133ASP A 174ALA A 175LEU A 203 | SAM A 501 (-3.6A)SAM A 501 (-2.3A)SAM A 501 (-3.4A)SAM A 501 (-3.8A)SAM A 501 (-4.6A) | 0.81A | 5x6yC-3vywA:6.0 | 5x6yC-3vywA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0y | DSZC (Rhodococcuserythropolis) |
PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 5 | VAL A 345GLY A 347ALA A 319LEU A 256ASN A 260 | None | 1.19A | 5x6yC-3x0yA:undetectable | 5x6yC-3x0yA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4by9 | FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Pyrococcusfuriosus) |
PF01269(Fibrillarin) | 5 | GLY E 81GLU E 105SER E 107ASP E 130ALA E 131 | NoneNone G A 22 ( 2.7A)NoneNone | 0.78A | 5x6yC-4by9E:6.3 | 5x6yC-4by9E:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2i | LARGE T ANTIGEN (Macaca mulattapolyomavirus 1) |
PF06431(Polyoma_lg_T_C) | 5 | VAL A 625GLY A 624ALA A 389SER A 560LEU A 563 | None | 1.05A | 5x6yC-4e2iA:2.9 | 5x6yC-4e2iA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0e | POLY [ADP-RIBOSE]POLYMERASE 15 (Homo sapiens) |
PF00644(PARP) | 5 | GLY A 589LYS A 584ASP A 540ALA A 541SER A 587 | NoneNone0RU A 701 (-3.3A)NoneNone | 1.12A | 5x6yC-4f0eA:undetectable | 5x6yC-4f0eA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 5 | VAL A 25GLY A 445ASP A 454ALA A 450SER A 23 | None | 1.18A | 5x6yC-4fxsA:undetectable | 5x6yC-4fxsA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gdf | LARGE T ANTIGEN (Macaca mulattapolyomavirus 1) |
PF02217(T_Ag_DNA_bind)PF06431(Polyoma_lg_T_C) | 5 | VAL A 625GLY A 624ALA A 389SER A 560LEU A 563 | None | 0.97A | 5x6yC-4gdfA:undetectable | 5x6yC-4gdfA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvl | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | GLY A 358ASP A 397ALA A 398LEU A 428ASN A 425 | AMP A 602 (-3.6A)AMP A 602 (-3.1A)AMP A 602 (-3.7A)NoneNone | 1.13A | 5x6yC-4gvlA:5.3 | 5x6yC-4gvlA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvr | METHENYLTETRAHYDROMETHANOPTERINCYCLOHYDROLASE (Archaeoglobusfulgidus) |
PF02289(MCH) | 5 | VAL A 235GLY A 207GLU A 80ALA A 188LEU A 237 | None | 1.13A | 5x6yC-4gvrA:undetectable | 5x6yC-4gvrA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikh | GLUTATHIONES-TRANSFERASE (Pseudomonasprotegens) |
PF00043(GST_C)PF02798(GST_N) | 5 | VAL A 133GLY A 134ALA A 199LEU A 193ASN A 192 | None | 1.13A | 5x6yC-4ikhA:undetectable | 5x6yC-4ikhA:15.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ix2 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH) | 5 | VAL A 25GLY A 445ASP A 454ALA A 450SER A 23 | None | 1.22A | 5x6yC-4ix2A:undetectable | 5x6yC-4ix2A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0m | SERINE/THREONINE-PROTEIN KINASEBRI1-LIKE 1 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | VAL A 53SER A 48SER A 87LEU A 84ASN A 112 | None | 1.19A | 5x6yC-4j0mA:2.8 | 5x6yC-4j0mA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9v | POTASSIUM UPTAKEPROTEIN TRKA (Vibrioparahaemolyticus) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | VAL A 238GLY A 239GLU A 261ASP A 283ALA A 284 | NoneAGS A 502 (-3.3A)AGS A 502 (-2.4A)AGS A 502 (-2.9A)AGS A 502 (-3.2A) | 0.63A | 5x6yC-4j9vA:5.1 | 5x6yC-4j9vA:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kg7 | PEPTIDASE S8 ANDS53, SUBTILISIN,KEXIN, SEDOLISIN (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | VAL A 287GLY A 309SER A 341ALA A 306SER A 294 | None | 1.21A | 5x6yC-4kg7A:1.6 | 5x6yC-4kg7A:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lqx | TENA/THI-4DOMAIN-CONTAININGPROTEIN (Sulfolobussolfataricus) |
PF03070(TENA_THI-4)PF16293(zf-C2H2_9) | 6 | VAL A 96GLY A 95GLU A 294SER A 296ALA A 88LEU A 287 | NoneNoneNone CL A 406 (-3.1A)NoneNone | 1.46A | 5x6yC-4lqxA:undetectable | 5x6yC-4lqxA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nax | GLUTATHIONES-TRANSFERASE,N-TERMINAL DOMAINPROTEIN (Pseudomonasputida) |
PF00043(GST_C)PF02798(GST_N) | 5 | VAL A 133GLY A 134ALA A 198LEU A 192ASN A 191 | None | 1.15A | 5x6yC-4naxA:undetectable | 5x6yC-4naxA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o29 | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Pyrobaculumaerophilum) |
PF01135(PCMT) | 5 | VAL A 79GLY A 80GLU A 104ASP A 132LEU A 204 | NoneSAH A 500 (-3.1A)SAH A 500 (-2.8A)SAH A 500 (-4.0A)SAH A 500 (-4.3A) | 0.96A | 5x6yC-4o29A:6.0 | 5x6yC-4o29A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o3s | DNA POLYMERASE ETA (Homo sapiens) |
PF00817(IMS)PF11799(IMS_C) | 5 | VAL A 37SER A 41ASP A 66ALA A 65LEU A 77 | None | 1.11A | 5x6yC-4o3sA:undetectable | 5x6yC-4o3sA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 5 | VAL A 79GLY A 80ASP A 130ALA A 131SER A 149 | NoneSAH A 301 (-2.7A)SAH A 301 (-2.7A)SAH A 301 (-3.5A)SAH A 301 (-4.7A) | 0.73A | 5x6yC-4pneA:5.1 | 5x6yC-4pneA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 6 | VAL A 123GLY A 124GLU A 147ASP A 178ALA A 179LEU A 207 | NoneMTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)MTA A 401 (-3.6A)MTA A 401 (-4.4A) | 0.74A | 5x6yC-4uoeA:7.2 | 5x6yC-4uoeA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwq | SULFUR OXIDATIONPROTEIN SOXB (Thermusthermophilus) |
PF02872(5_nucleotid_C) | 5 | VAL A 218GLY A 219ALA A 40LEU A 223ASN A 267 | None | 0.89A | 5x6yC-4uwqA:3.2 | 5x6yC-4uwqA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x28 | ACYL-COADEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 5 | VAL D 152GLY D 153SER D 90ALA D 124LEU D 199 | None | 1.20A | 5x6yC-4x28D:undetectable | 5x6yC-4x28D:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y21 | PROTEIN UNC-13HOMOLOG A (Rattusnorvegicus) |
PF06292(DUF1041)PF10540(Membr_traf_MHD) | 5 | VAL A 332ASP A 252LEU A 336ASN A 338ASN A 339 | None | 1.01A | 5x6yC-4y21A:undetectable | 5x6yC-4y21A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zal | UBIX (Pseudomonasaeruginosa) |
PF02441(Flavoprotein) | 5 | GLY A 114SER A 109ALA A 124ASN A 117ASN A 118 | None | 1.08A | 5x6yC-4zalA:undetectable | 5x6yC-4zalA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5g | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 5 | VAL A 225SER A 521ALA A 236LEU A 141ASN A 138 | None | 1.19A | 5x6yC-5a5gA:undetectable | 5x6yC-5a5gA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5t | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT M (Oryctolaguscuniculus) |
PF01399(PCI) | 5 | VAL M 130GLY M 96GLU M 95SER M 100LEU M 103 | None | 1.09A | 5x6yC-5a5tM:undetectable | 5x6yC-5a5tM:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITGAMMA (Methanothermobactermarburgensis) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | VAL B 347GLY B 346GLU B 339ALA B 352LEU B 310 | None | 1.18A | 5x6yC-5a8rB:undetectable | 5x6yC-5a8rB:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 5 | VAL A1879GLY A1880ASP A1938ALA A1935LEU A1870 | None | 0.89A | 5x6yC-5cslA:3.8 | 5x6yC-5cslA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e78 | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00067(p450) | 5 | VAL A 317GLU A 377ALA A 290LEU A 280ASN A 283 | None | 0.85A | 5x6yC-5e78A:undetectable | 5x6yC-5e78A:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fbz | ENZYME SUBTILASESUBHAL FROM BACILLUSHALMAPALUS (Bacillushalmapalus) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | VAL A 422GLY A 423ASP A 352ALA A 353ASN A 419 | None | 1.00A | 5x6yC-5fbzA:undetectable | 5x6yC-5fbzA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffn | ENZYME SUBTILASESUBTY FROM BACILLUSSP. TY145 (Bacillus sp.(in: Bacteria)) |
PF00082(Peptidase_S8) | 5 | VAL A 38GLY A 73SER A 140ALA A 102LEU A 100 | None | 1.25A | 5x6yC-5ffnA:undetectable | 5x6yC-5ffnA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6i | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | VAL A1920GLY A1921ASP A1979ALA A1976LEU A1911 | None | 0.85A | 5x6yC-5i6iA:undetectable | 5x6yC-5i6iA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic1 | TALIN-1 (Mus musculus) |
no annotation | 5 | VAL A1731GLY A1728GLU A1660ALA A1664LEU A1776 | None | 1.21A | 5x6yC-5ic1A:undetectable | 5x6yC-5ic1A:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihr | PROBABLEBETA-GALACTOSIDASE A (Aspergillusniger) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | VAL A 155GLY A 157SER A 162ALA A 169LEU A 152 | DMS A3008 (-4.1A)NoneNoneDMS A3008 ( 4.1A)None | 1.19A | 5x6yC-5ihrA:undetectable | 5x6yC-5ihrA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m09 | SERINE/THREONINE-PROTEIN KINASE PKNI (Mycobacteriumtuberculosis) |
PF00069(Pkinase) | 5 | VAL A 179ASP A 184ALA A 183LEU A 173ASN A 136 | None | 1.25A | 5x6yC-5m09A:undetectable | 5x6yC-5m09A:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mvd | DIHYDROOROTATEDEHYDROGENASE(QUINONE),MITOCHONDRIAL (Homo sapiens) |
PF01180(DHO_dh) | 5 | VAL A 353GLY A 332SER A 313ASP A 341ALA A 342 | None | 1.06A | 5x6yC-5mvdA:undetectable | 5x6yC-5mvdA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE, BETASUBUNIT (Methanotorrisformicicus) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | VAL B 348GLY B 347GLU B 340ALA B 353LEU B 311 | None | 1.17A | 5x6yC-5n28B:undetectable | 5x6yC-5n28B:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4n | FRUCTOSE-1 (Neisseriagonorrhoeae) |
PF01116(F_bP_aldolase) | 5 | VAL A 145GLY A 144SER A 107LEU A 108ASN A 121 | None | 1.25A | 5x6yC-5u4nA:undetectable | 5x6yC-5u4nA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz4 | SMALL RIBOSOMALSUBUNIT BIOGENESISGTPASE RSGA (Escherichiacoli) |
PF03193(RsgA_GTPase) | 5 | VAL Z 270GLY Z 269GLU Z 272ALA Z 213SER Z 267 | None G A1494 ( 2.2A)GGM Z 402 ( 4.2A)None G A1494 ( 4.5A) | 1.04A | 5x6yC-5uz4Z:undetectable | 5x6yC-5uz4Z:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz4 | SMALL RIBOSOMALSUBUNIT BIOGENESISGTPASE RSGA (Escherichiacoli) |
PF03193(RsgA_GTPase) | 5 | VAL Z 270GLY Z 269GLU Z 272SER Z 216ALA Z 213 | None G A1494 ( 2.2A)GGM Z 402 ( 4.2A)NoneNone | 1.07A | 5x6yC-5uz4Z:undetectable | 5x6yC-5uz4Z:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voh | NADH OXIDASE (Lactobacillusbrevis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | VAL A 6GLY A 7GLU A 32LEU A 248ASN A 245 | NoneFAD A 501 (-3.1A)FAD A 501 (-2.4A)FAD A 501 (-4.7A)FAD A 501 (-2.8A) | 1.09A | 5x6yC-5vohA:undetectable | 5x6yC-5vohA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdr | RAS PROTEIN (Choanoflagellida) |
PF00071(Ras) | 5 | VAL A 114GLY A 115SER A 146ALA A 156LEU A 79 | NoneNoneGNP A 203 (-3.5A)NoneNone | 1.24A | 5x6yC-5wdrA:undetectable | 5x6yC-5wdrA:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1y | MERCURIC REDUCTASE (Lysinibacillussphaericus) |
no annotation | 5 | GLY B 91GLU B 114ALA B 195LEU B 354ASN B 350 | FAD B 601 (-3.3A)FAD B 601 (-2.6A)FAD B 601 (-3.8A)FAD B 601 (-4.6A)FAD B 601 ( 4.1A) | 1.20A | 5x6yC-5x1yB:undetectable | 5x6yC-5x1yB:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 9 | VAL C 209GLY C 210GLU C 230LYS C 231ASP C 471ALA C 472LEU C 489ASN C 491ASN C 494 | None | 1.04A | 5x6yC-5x6xC:53.1 | 5x6yC-5x6xC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 9 | VAL C 209GLY C 210LYS C 231ASP C 471ALA C 472SER C 488LEU C 489ASN C 491ASN C 494 | None | 1.23A | 5x6yC-5x6xC:53.1 | 5x6yC-5x6xC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 8 | VAL C 209LYS C 231SER C 232ASP C 471ALA C 472SER C 488LEU C 489ASN C 494 | None | 1.00A | 5x6yC-5x6xC:53.1 | 5x6yC-5x6xC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINUS13 (Toxoplasmagondii) |
PF00416(Ribosomal_S13) | 5 | VAL S 101GLY S 37SER S 43ALA S 73LEU S 18 | None U 21565 ( 3.3A)NoneNoneNone | 1.21A | 5x6yC-5xxuS:undetectable | 5x6yC-5xxuS:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z2g | L-AMINO ACID OXIDASE (Naja atra) |
no annotation | 5 | VAL A 58GLY A 59GLU A 82SER A 84SER A 311 | FAD A 604 (-4.5A)FAD A 604 (-3.2A)FAD A 604 (-2.7A)FAD A 604 ( 4.0A)FAD A 604 (-4.2A) | 1.04A | 5x6yC-5z2gA:undetectable | 5x6yC-5z2gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2y | SOLUTE-BINDINGPERIPLASMIC PROTEINOF IRON/SIDEROPHOREABC TRANSPORTER (Yersinia pestis) |
no annotation | 5 | VAL A 253GLY A 252ALA A 240SER A 267LEU A 268 | None | 0.87A | 5x6yC-6b2yA:undetectable | 5x6yC-6b2yA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f76 | - (-) |
no annotation | 5 | VAL B 114GLY B 115SER B 145ALA B 155LEU B 79 | NoneNoneGNP B 202 (-3.6A)NoneNone | 1.24A | 5x6yC-6f76B:undetectable | 5x6yC-6f76B:undetectable |