SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_C_SAMC901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dts DETHIOBIOTIN
SYNTHETASE


(Escherichia
coli)
PF13500
(AAA_26)
5 GLY A  35
ASP A 110
ALA A 109
SER A  62
LEU A  64
None
1.08A 5x6yC-1dtsA:
2.6
5x6yC-1dtsA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT


(Methanopyrus
kandleri)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
None
1.25A 5x6yC-1e6vB:
undetectable
5x6yC-1e6vB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 VAL A  15
GLY A  16
GLU A  39
LYS A  40
ALA A 119
ASN A 277
None
FAD  A 462 (-3.4A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.1A)
FAD  A 462 (-4.0A)
None
0.86A 5x6yC-1ebdA:
undetectable
5x6yC-1ebdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggv DIENELACTONE
HYDROLASE


(Pseudomonas
putida)
PF01738
(DLH)
5 VAL A 147
GLY A 148
GLU A 150
SER A 178
ASP A 171
SEB  A 123 ( 4.3A)
None
None
None
None
1.15A 5x6yC-1ggvA:
2.1
5x6yC-1ggvA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays)
PF01593
(Amino_oxidase)
5 VAL A 270
GLY A 269
ASP A 396
SER A 273
LEU A 275
FAD  A 579 ( 4.9A)
None
None
None
FAD  A 579 (-4.5A)
1.23A 5x6yC-1h81A:
undetectable
5x6yC-1h81A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE


(Escherichia
coli)
PF03275
(GLF)
PF13450
(NAD_binding_8)
5 VAL A   7
GLY A   8
GLU A  31
LYS A  32
ASP A 212
FAD  A 450 (-4.7A)
FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
0.51A 5x6yC-1i8tA:
undetectable
5x6yC-1i8tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN


(Mus musculus)
PF02816
(Alpha_kinase)
5 GLY A1792
GLU A1672
LEU A1796
ASN A1795
ASN A1731
None
1.06A 5x6yC-1iahA:
undetectable
5x6yC-1iahA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN


(Mus musculus)
PF02816
(Alpha_kinase)
5 VAL A1790
GLY A1792
LEU A1796
ASN A1795
ASN A1731
None
1.08A 5x6yC-1iahA:
undetectable
5x6yC-1iahA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Pyrococcus
furiosus)
PF01135
(PCMT)
5 VAL A  98
GLY A  99
GLU A 121
ASP A 148
LEU A 221
None
ADN  A 500 (-3.2A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.2A)
1.01A 5x6yC-1jg3A:
4.7
5x6yC-1jg3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Comamonas
testosteroni)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
5 VAL A  69
GLY A  68
ALA A 538
SER A  65
LEU A  63
None
1.11A 5x6yC-1kb0A:
undetectable
5x6yC-1kb0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Comamonas
testosteroni)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
5 VAL A  69
GLY A 540
ALA A 538
SER A  65
LEU A  63
None
1.19A 5x6yC-1kb0A:
undetectable
5x6yC-1kb0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7b DNA LIGASE

(Thermus
thermophilus)
PF00533
(BRCT)
5 VAL A  50
GLY A  51
SER A  20
ALA A  61
ASN A  53
None
1.14A 5x6yC-1l7bA:
undetectable
5x6yC-1l7bA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A  82
GLU A 104
ASP A 141
SER A 159
LEU A 169
None
0.98A 5x6yC-1mjfA:
6.9
5x6yC-1mjfA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE


(Pseudomonas sp.
P51)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 VAL A 356
GLY A 355
SER A 119
ALA A 306
LEU A 339
None
1.20A 5x6yC-1nu5A:
undetectable
5x6yC-1nu5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE


(Plasmodium
falciparum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A   8
GLU A  31
LYS A  32
SER A  33
ALA A 110
FAD  A 500 (-2.8A)
FAD  A 500 (-2.6A)
FAD  A 500 (-3.3A)
FAD  A 500 ( 4.0A)
FAD  A 500 (-3.3A)
0.74A 5x6yC-1onfA:
undetectable
5x6yC-1onfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus)
PF00491
(Arginase)
5 VAL A  96
ALA A  13
SER A 107
LEU A  80
ASN A  77
None
1.06A 5x6yC-1p8rA:
4.5
5x6yC-1p8rA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN


(Pseudomonas
aeruginosa)
PF13433
(Peripla_BP_5)
5 VAL A 206
GLY A 207
GLU A 238
SER A 235
ASN A 106
None
None
None
None
BMD  A1001 ( 4.0A)
1.18A 5x6yC-1qnlA:
3.2
5x6yC-1qnlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A  28
GLY A  71
ASP A 129
ALA A 128
LEU A  77
None
1.24A 5x6yC-1rjwA:
2.4
5x6yC-1rjwA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE


(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
5 VAL A   6
GLY A   7
ALA A  75
LEU A 230
ASN A 227
None
FAD  A 360 (-3.2A)
FAD  A 360 (-3.6A)
FAD  A 360 ( 4.3A)
None
1.02A 5x6yC-1xhcA:
undetectable
5x6yC-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE


(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
5 VAL A   6
GLY A   7
LYS A  30
ALA A  75
ASN A 227
None
FAD  A 360 (-3.2A)
FAD  A 360 (-4.7A)
FAD  A 360 (-3.6A)
None
1.05A 5x6yC-1xhcA:
undetectable
5x6yC-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6z HEAT SHOCK PROTEIN,
PUTATIVE


(Plasmodium
falciparum)
PF00183
(HSP90)
5 VAL A 160
ALA A 171
SER A 243
LEU A 244
ASN A 247
None
1.19A 5x6yC-1y6zA:
undetectable
5x6yC-1y6zA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE


(Luciola
cruciata)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 VAL A 325
GLY A 326
SER A 316
SER A 322
LEU A 461
None
1.16A 5x6yC-2d1qA:
4.4
5x6yC-2d1qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE


(Bacillus
subtilis)
PF02390
(Methyltransf_4)
5 VAL A  45
GLY A  46
GLU A  69
ASP A  96
ALA A  97
None
K  A 250 (-3.9A)
None
None
None
1.03A 5x6yC-2fcaA:
2.4
5x6yC-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN


(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 VAL A  37
GLY A  72
SER A 138
ALA A 100
LEU A  98
None
1.23A 5x6yC-2gkoA:
undetectable
5x6yC-2gkoA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
5 VAL A  41
GLY A  42
GLU A  71
ALA A 167
LEU A 219
FAD  A 611 (-4.9A)
FAD  A 611 (-3.3A)
FAD  A 611 (-2.9A)
FAD  A 611 (-3.3A)
FAD  A 611 (-4.4A)
0.65A 5x6yC-2gmhA:
undetectable
5x6yC-2gmhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR


(Rhodococcus
jostii)
PF00392
(GntR)
PF07729
(FCD)
5 VAL A 144
GLY A 145
ALA A 132
LEU A 193
ASN A 196
None
0.94A 5x6yC-2hs5A:
undetectable
5x6yC-2hs5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLU A 147
ASP A 178
ALA A 179
SER A 197
LEU A 207
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
None
S4M  A 501 (-4.4A)
1.11A 5x6yC-2pt6A:
8.0
5x6yC-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
6 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
0.79A 5x6yC-2pt6A:
8.0
5x6yC-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE


(Marichromatium
gracile)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A  11
GLU A  34
ALA A 114
LEU A 269
ASN A 265
FAD  A 500 (-3.1A)
FAD  A 500 (-2.7A)
FAD  A 500 (-3.8A)
FAD  A 500 (-4.6A)
FAD  A 500 ( 4.7A)
1.09A 5x6yC-2r9zA:
undetectable
5x6yC-2r9zA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE


(Staphylococcus
aureus)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 VAL A 366
GLY A 365
GLU A 393
ALA A 406
LEU A 389
None
1.24A 5x6yC-2vpqA:
2.3
5x6yC-2vpqA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes)
PF08241
(Methyltransf_11)
5 VAL A  68
GLY A  69
ASP A 119
ALA A 120
SER A 138
None
SAH  A 274 (-3.1A)
SAH  A 274 (-3.6A)
SAH  A 274 (-3.5A)
None
0.76A 5x6yC-3busA:
5.9
5x6yC-3busA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE


(Desulfovibrio
alaskensis)
PF09837
(DUF2064)
5 VAL A 105
SER A   2
ASP A 100
ALA A  97
LEU A   7
None
1.09A 5x6yC-3cgxA:
undetectable
5x6yC-3cgxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli)
PF00884
(Sulfatase)
5 GLY A 212
GLU A 240
ASP A 293
ALA A 294
SER A 216
None
1.03A 5x6yC-3ed4A:
2.7
5x6yC-3ed4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE


(Thermus
thermophilus)
PF00398
(RrnaAD)
7 VAL A  53
GLY A  54
GLU A  75
LYS A  76
ASP A  99
ALA A 100
LEU A 126
None
0.88A 5x6yC-3futA:
4.3
5x6yC-3futA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE


(Thermus
thermophilus)
PF00398
(RrnaAD)
5 VAL A  53
GLY A  54
GLU A  75
LYS A  76
LEU A 118
None
0.90A 5x6yC-3futA:
4.3
5x6yC-3futA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL


(Escherichia
coli)
PF02254
(TrkA_N)
5 VAL A 423
GLY A 424
GLU A 447
ALA A 468
LEU A 487
AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
AMP  A 601 (-3.9A)
None
1.23A 5x6yC-3fwzA:
3.1
5x6yC-3fwzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL


(Escherichia
coli)
PF02254
(TrkA_N)
5 VAL A 423
GLY A 424
GLU A 447
SER A 449
ALA A 468
AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
None
AMP  A 601 (-3.9A)
0.90A 5x6yC-3fwzA:
3.1
5x6yC-3fwzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)


(Clostridium
acetobutylicum)
PF13377
(Peripla_BP_3)
5 VAL A 257
GLY A 256
ALA A 233
LEU A 261
ASN A 262
None
1.12A 5x6yC-3g85A:
undetectable
5x6yC-3g85A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE


(Corynebacterium
glutamicum)
PF13649
(Methyltransf_25)
5 VAL A 105
GLY A 106
GLU A 127
SER A 168
LEU A 169
None
SAH  A 301 (-3.4A)
SAH  A 301 (-2.6A)
SAH  A 301 (-4.7A)
None
1.16A 5x6yC-3h2bA:
7.2
5x6yC-3h2bA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF03063
(Prismane)
5 VAL A 331
GLY A 314
ALA A 340
LEU A 271
ASN A 311
None
1.23A 5x6yC-3i04A:
2.2
5x6yC-3i04A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F


(Bacteroides
fragilis)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
5 VAL A 106
LYS A 109
SER A 110
ALA A 203
LEU A 199
None
1.25A 5x6yC-3ks7A:
undetectable
5x6yC-3ks7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 VAL A  19
GLY A  20
GLU A  44
ALA A 232
LEU A 277
None
FDA  A 547 (-3.2A)
FDA  A 547 (-2.7A)
FDA  A 547 (-3.6A)
None
0.75A 5x6yC-3ljpA:
undetectable
5x6yC-3ljpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE


(Oleispira
antarctica)
PF00857
(Isochorismatase)
5 VAL A 118
GLY A 119
ASP A 145
ALA A 143
LEU A  42
None
0.99A 5x6yC-3lqyA:
undetectable
5x6yC-3lqyA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE


(Bordetella
bronchiseptica)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 VAL A 142
GLY A 143
GLU A 308
ALA A 310
LEU A 312
None
1.09A 5x6yC-3moiA:
2.0
5x6yC-3moiA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A


(Rattus
norvegicus)
PF10540
(Membr_traf_MHD)
5 VAL A1264
ASP A1184
LEU A1268
ASN A1270
ASN A1271
None
1.03A 5x6yC-3swhA:
undetectable
5x6yC-3swhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE


(Leishmania
donovani)
PF00291
(PALP)
5 VAL A 185
GLY A 186
SER A 274
ALA A 209
LEU A 191
LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.5A)
LLP  A  51 ( 2.6A)
None
None
1.21A 5x6yC-3tbhA:
3.0
5x6yC-3tbhA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Coxiella
burnetii)
PF00398
(RrnaAD)
5 GLY A  40
GLU A  61
ASP A  86
ALA A  87
LEU A 115
None
0.89A 5x6yC-3tqsA:
4.5
5x6yC-3tqsA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Burkholderia
pseudomallei)
PF00398
(RrnaAD)
5 GLY A  46
GLU A  71
ASP A  94
ALA A  95
LEU A 126
None
0.97A 5x6yC-3uzuA:
4.4
5x6yC-3uzuA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum)
PF13378
(MR_MLE_C)
5 VAL A 381
GLY A 380
SER A 132
ALA A 329
LEU A 364
None
1.16A 5x6yC-3va8A:
undetectable
5x6yC-3va8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus)
PF05430
(Methyltransf_30)
5 GLU A 133
LYS A 134
ASP A 174
ALA A 175
LEU A 203
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.6A)
0.87A 5x6yC-3vywA:
6.0
5x6yC-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus)
PF05430
(Methyltransf_30)
5 GLY A 104
GLU A 133
ASP A 174
ALA A 175
LEU A 203
SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.6A)
0.81A 5x6yC-3vywA:
6.0
5x6yC-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
5 VAL A 345
GLY A 347
ALA A 319
LEU A 256
ASN A 260
None
1.19A 5x6yC-3x0yA:
undetectable
5x6yC-3x0yA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE


(Pyrococcus
furiosus)
PF01269
(Fibrillarin)
5 GLY E  81
GLU E 105
SER E 107
ASP E 130
ALA E 131
None
None
G  A  22 ( 2.7A)
None
None
0.78A 5x6yC-4by9E:
6.3
5x6yC-4by9E:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1)
PF06431
(Polyoma_lg_T_C)
5 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
None
1.05A 5x6yC-4e2iA:
2.9
5x6yC-4e2iA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0e POLY [ADP-RIBOSE]
POLYMERASE 15


(Homo sapiens)
PF00644
(PARP)
5 GLY A 589
LYS A 584
ASP A 540
ALA A 541
SER A 587
None
None
0RU  A 701 (-3.3A)
None
None
1.12A 5x6yC-4f0eA:
undetectable
5x6yC-4f0eA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
PF00571
(CBS)
5 VAL A  25
GLY A 445
ASP A 454
ALA A 450
SER A  23
None
1.18A 5x6yC-4fxsA:
undetectable
5x6yC-4fxsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1)
PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C)
5 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
None
0.97A 5x6yC-4gdfA:
undetectable
5x6yC-4gdfA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
5 GLY A 358
ASP A 397
ALA A 398
LEU A 428
ASN A 425
AMP  A 602 (-3.6A)
AMP  A 602 (-3.1A)
AMP  A 602 (-3.7A)
None
None
1.13A 5x6yC-4gvlA:
5.3
5x6yC-4gvlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE


(Archaeoglobus
fulgidus)
PF02289
(MCH)
5 VAL A 235
GLY A 207
GLU A  80
ALA A 188
LEU A 237
None
1.13A 5x6yC-4gvrA:
undetectable
5x6yC-4gvrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikh GLUTATHIONE
S-TRANSFERASE


(Pseudomonas
protegens)
PF00043
(GST_C)
PF02798
(GST_N)
5 VAL A 133
GLY A 134
ALA A 199
LEU A 193
ASN A 192
None
1.13A 5x6yC-4ikhA:
undetectable
5x6yC-4ikhA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
5 VAL A  25
GLY A 445
ASP A 454
ALA A 450
SER A  23
None
1.22A 5x6yC-4ix2A:
undetectable
5x6yC-4ix2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1


(Arabidopsis
thaliana)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 VAL A  53
SER A  48
SER A  87
LEU A  84
ASN A 112
None
1.19A 5x6yC-4j0mA:
2.8
5x6yC-4j0mA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA


(Vibrio
parahaemolyticus)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
5 VAL A 238
GLY A 239
GLU A 261
ASP A 283
ALA A 284
None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
0.63A 5x6yC-4j9vA:
5.1
5x6yC-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 VAL A 287
GLY A 309
SER A 341
ALA A 306
SER A 294
None
1.21A 5x6yC-4kg7A:
1.6
5x6yC-4kg7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqx TENA/THI-4
DOMAIN-CONTAINING
PROTEIN


(Sulfolobus
solfataricus)
PF03070
(TENA_THI-4)
PF16293
(zf-C2H2_9)
6 VAL A  96
GLY A  95
GLU A 294
SER A 296
ALA A  88
LEU A 287
None
None
None
CL  A 406 (-3.1A)
None
None
1.46A 5x6yC-4lqxA:
undetectable
5x6yC-4lqxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN


(Pseudomonas
putida)
PF00043
(GST_C)
PF02798
(GST_N)
5 VAL A 133
GLY A 134
ALA A 198
LEU A 192
ASN A 191
None
1.15A 5x6yC-4naxA:
undetectable
5x6yC-4naxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o29 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Pyrobaculum
aerophilum)
PF01135
(PCMT)
5 VAL A  79
GLY A  80
GLU A 104
ASP A 132
LEU A 204
None
SAH  A 500 (-3.1A)
SAH  A 500 (-2.8A)
SAH  A 500 (-4.0A)
SAH  A 500 (-4.3A)
0.96A 5x6yC-4o29A:
6.0
5x6yC-4o29A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens)
PF00817
(IMS)
PF11799
(IMS_C)
5 VAL A  37
SER A  41
ASP A  66
ALA A  65
LEU A  77
None
1.11A 5x6yC-4o3sA:
undetectable
5x6yC-4o3sA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
5 VAL A  79
GLY A  80
ASP A 130
ALA A 131
SER A 149
None
SAH  A 301 (-2.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.7A)
0.73A 5x6yC-4pneA:
5.1
5x6yC-4pneA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
6 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
None
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
MTA  A 401 (-4.4A)
0.74A 5x6yC-4uoeA:
7.2
5x6yC-4uoeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB


(Thermus
thermophilus)
PF02872
(5_nucleotid_C)
5 VAL A 218
GLY A 219
ALA A  40
LEU A 223
ASN A 267
None
0.89A 5x6yC-4uwqA:
3.2
5x6yC-4uwqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE


(Mycobacterium
tuberculosis)
no annotation 5 VAL D 152
GLY D 153
SER D  90
ALA D 124
LEU D 199
None
1.20A 5x6yC-4x28D:
undetectable
5x6yC-4x28D:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A


(Rattus
norvegicus)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD)
5 VAL A 332
ASP A 252
LEU A 336
ASN A 338
ASN A 339
None
1.01A 5x6yC-4y21A:
undetectable
5x6yC-4y21A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zal UBIX

(Pseudomonas
aeruginosa)
PF02441
(Flavoprotein)
5 GLY A 114
SER A 109
ALA A 124
ASN A 117
ASN A 118
None
1.08A 5x6yC-4zalA:
undetectable
5x6yC-4zalA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
5 VAL A 225
SER A 521
ALA A 236
LEU A 141
ASN A 138
None
1.19A 5x6yC-5a5gA:
undetectable
5x6yC-5a5gA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M


(Oryctolagus
cuniculus)
PF01399
(PCI)
5 VAL M 130
GLY M  96
GLU M  95
SER M 100
LEU M 103
None
1.09A 5x6yC-5a5tM:
undetectable
5x6yC-5a5tM:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA


(Methanothermobacter
marburgensis)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 VAL B 347
GLY B 346
GLU B 339
ALA B 352
LEU B 310
None
1.18A 5x6yC-5a8rB:
undetectable
5x6yC-5a8rB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
5 VAL A1879
GLY A1880
ASP A1938
ALA A1935
LEU A1870
None
0.89A 5x6yC-5cslA:
3.8
5x6yC-5cslA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
5 VAL A 317
GLU A 377
ALA A 290
LEU A 280
ASN A 283
None
0.85A 5x6yC-5e78A:
undetectable
5x6yC-5e78A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS


(Bacillus
halmapalus)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 VAL A 422
GLY A 423
ASP A 352
ALA A 353
ASN A 419
None
1.00A 5x6yC-5fbzA:
undetectable
5x6yC-5fbzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145


(Bacillus sp.
(in: Bacteria))
PF00082
(Peptidase_S8)
5 VAL A  38
GLY A  73
SER A 140
ALA A 102
LEU A 100
None
1.25A 5x6yC-5ffnA:
undetectable
5x6yC-5ffnA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 VAL A1920
GLY A1921
ASP A1979
ALA A1976
LEU A1911
None
0.85A 5x6yC-5i6iA:
undetectable
5x6yC-5i6iA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus)
no annotation 5 VAL A1731
GLY A1728
GLU A1660
ALA A1664
LEU A1776
None
1.21A 5x6yC-5ic1A:
undetectable
5x6yC-5ic1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A


(Aspergillus
niger)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
5 VAL A 155
GLY A 157
SER A 162
ALA A 169
LEU A 152
DMS  A3008 (-4.1A)
None
None
DMS  A3008 ( 4.1A)
None
1.19A 5x6yC-5ihrA:
undetectable
5x6yC-5ihrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
5 VAL A 179
ASP A 184
ALA A 183
LEU A 173
ASN A 136
None
1.25A 5x6yC-5m09A:
undetectable
5x6yC-5m09A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL


(Homo sapiens)
PF01180
(DHO_dh)
5 VAL A 353
GLY A 332
SER A 313
ASP A 341
ALA A 342
None
1.06A 5x6yC-5mvdA:
undetectable
5x6yC-5mvdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT


(Methanotorris
formicicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
None
1.17A 5x6yC-5n28B:
undetectable
5x6yC-5n28B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae)
PF01116
(F_bP_aldolase)
5 VAL A 145
GLY A 144
SER A 107
LEU A 108
ASN A 121
None
1.25A 5x6yC-5u4nA:
undetectable
5x6yC-5u4nA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz4 SMALL RIBOSOMAL
SUBUNIT BIOGENESIS
GTPASE RSGA


(Escherichia
coli)
PF03193
(RsgA_GTPase)
5 VAL Z 270
GLY Z 269
GLU Z 272
ALA Z 213
SER Z 267
None
G  A1494 ( 2.2A)
GGM  Z 402 ( 4.2A)
None
G  A1494 ( 4.5A)
1.04A 5x6yC-5uz4Z:
undetectable
5x6yC-5uz4Z:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz4 SMALL RIBOSOMAL
SUBUNIT BIOGENESIS
GTPASE RSGA


(Escherichia
coli)
PF03193
(RsgA_GTPase)
5 VAL Z 270
GLY Z 269
GLU Z 272
SER Z 216
ALA Z 213
None
G  A1494 ( 2.2A)
GGM  Z 402 ( 4.2A)
None
None
1.07A 5x6yC-5uz4Z:
undetectable
5x6yC-5uz4Z:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 VAL A   6
GLY A   7
GLU A  32
LEU A 248
ASN A 245
None
FAD  A 501 (-3.1A)
FAD  A 501 (-2.4A)
FAD  A 501 (-4.7A)
FAD  A 501 (-2.8A)
1.09A 5x6yC-5vohA:
undetectable
5x6yC-5vohA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida)
PF00071
(Ras)
5 VAL A 114
GLY A 115
SER A 146
ALA A 156
LEU A  79
None
None
GNP  A 203 (-3.5A)
None
None
1.24A 5x6yC-5wdrA:
undetectable
5x6yC-5wdrA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus)
no annotation 5 GLY B  91
GLU B 114
ALA B 195
LEU B 354
ASN B 350
FAD  B 601 (-3.3A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.8A)
FAD  B 601 (-4.6A)
FAD  B 601 ( 4.1A)
1.20A 5x6yC-5x1yB:
undetectable
5x6yC-5x1yB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 9 VAL C 209
GLY C 210
GLU C 230
LYS C 231
ASP C 471
ALA C 472
LEU C 489
ASN C 491
ASN C 494
None
1.04A 5x6yC-5x6xC:
53.1
5x6yC-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 9 VAL C 209
GLY C 210
LYS C 231
ASP C 471
ALA C 472
SER C 488
LEU C 489
ASN C 491
ASN C 494
None
1.23A 5x6yC-5x6xC:
53.1
5x6yC-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 8 VAL C 209
LYS C 231
SER C 232
ASP C 471
ALA C 472
SER C 488
LEU C 489
ASN C 494
None
1.00A 5x6yC-5x6xC:
53.1
5x6yC-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US13


(Toxoplasma
gondii)
PF00416
(Ribosomal_S13)
5 VAL S 101
GLY S  37
SER S  43
ALA S  73
LEU S  18
None
U  21565 ( 3.3A)
None
None
None
1.21A 5x6yC-5xxuS:
undetectable
5x6yC-5xxuS:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra)
no annotation 5 VAL A  58
GLY A  59
GLU A  82
SER A  84
SER A 311
FAD  A 604 (-4.5A)
FAD  A 604 (-3.2A)
FAD  A 604 (-2.7A)
FAD  A 604 ( 4.0A)
FAD  A 604 (-4.2A)
1.04A 5x6yC-5z2gA:
undetectable
5x6yC-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER


(Yersinia pestis)
no annotation 5 VAL A 253
GLY A 252
ALA A 240
SER A 267
LEU A 268
None
0.87A 5x6yC-6b2yA:
undetectable
5x6yC-6b2yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f76 -

(-)
no annotation 5 VAL B 114
GLY B 115
SER B 145
ALA B 155
LEU B  79
None
None
GNP  B 202 (-3.6A)
None
None
1.24A 5x6yC-6f76B:
undetectable
5x6yC-6f76B:
undetectable