SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_B_SAMB901
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dts | DETHIOBIOTINSYNTHETASE (Escherichiacoli) |
PF13500(AAA_26) | 5 | GLY A 35ASP A 110ALA A 109SER A 62LEU A 64 | None | 0.88A | 5x6yB-1dtsA:3.3 | 5x6yB-1dtsA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 6 | VAL A 15GLY A 16GLU A 39LYS A 40ALA A 119ASN A 277 | NoneFAD A 462 (-3.4A)FAD A 462 (-2.5A)FAD A 462 (-4.1A)FAD A 462 (-4.0A)None | 0.72A | 5x6yB-1ebdA:2.7 | 5x6yB-1ebdA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu8 | TREHALOSE/MALTOSEBINDING PROTEIN (Thermococcuslitoralis) |
PF01547(SBP_bac_1) | 5 | VAL A 188GLY A 193GLU A 211ALA A 215ASN A 208 | None | 1.11A | 5x6yB-1eu8A:undetectable | 5x6yB-1eu8A:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i8t | UDP-GALACTOPYRANOSEMUTASE (Escherichiacoli) |
PF03275(GLF)PF13450(NAD_binding_8) | 5 | VAL A 7GLY A 8GLU A 31LYS A 32ASP A 212 | FAD A 450 (-4.7A)FAD A 450 (-3.2A)FAD A 450 (-2.8A)FAD A 450 (-3.8A)FAD A 450 (-3.5A) | 0.74A | 5x6yB-1i8tA:2.0 | 5x6yB-1i8tA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iah | TRANSIENT RECEPTORPOTENTIAL-RELATEDPROTEIN (Mus musculus) |
PF02816(Alpha_kinase) | 5 | GLY A1792GLU A1672LEU A1796ASN A1795ASN A1731 | None | 1.10A | 5x6yB-1iahA:undetectable | 5x6yB-1iahA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jg3 | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Pyrococcusfuriosus) |
PF01135(PCMT) | 5 | VAL A 98GLY A 99GLU A 121ASP A 148LEU A 221 | NoneADN A 500 (-3.2A)ADN A 500 (-2.9A)ADN A 500 (-3.7A)ADN A 500 (-4.2A) | 1.11A | 5x6yB-1jg3A:undetectable | 5x6yB-1jg3A:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lla | HEMOCYANIN (SUBUNITTYPE II) (Limuluspolyphemus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | VAL A 84GLY A 38ALA A 80LEU A 60ASN A 36 | None | 1.06A | 5x6yB-1llaA:undetectable | 5x6yB-1llaA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjt | NITRIC-OXIDESYNTHASE HOMOLOG (Staphylococcusaureus) |
PF02898(NO_synthase) | 5 | VAL A 284GLY A 283ALA A 201LEU A 102ASN A 98 | None | 1.15A | 5x6yB-1mjtA:undetectable | 5x6yB-1mjtA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p8r | ARGINASE 1 (Rattusnorvegicus) |
PF00491(Arginase) | 5 | VAL A 96ALA A 13SER A 107LEU A 80ASN A 77 | None | 0.93A | 5x6yB-1p8rA:undetectable | 5x6yB-1p8rA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgs | PEPTIDE-N(4)-(N-ACETYL-BETA-D-GLUCOSAMINYL)ASPARAGINEAMIDASE F (Elizabethkingiameningoseptica) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 5 | GLY A 203ASP A 290ALA A 291ASN A 285ASN A 284 | None | 1.17A | 5x6yB-1pgsA:undetectable | 5x6yB-1pgsA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pov | POLIOVIRUS NATIVEEMPTY CAPSID (TYPE1) (Enterovirus C) |
PF00073(Rhv)PF02226(Pico_P1A) | 5 | VAL 0 193GLY 0 192ALA 0 275ASN 0 268ASN 0 272 | None | 1.22A | 5x6yB-1pov0:undetectable | 5x6yB-1pov0:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdj | BIOSYNTHETICTHREONINE DEAMINASE (Escherichiacoli) |
PF00291(PALP)PF00585(Thr_dehydrat_C) | 6 | VAL A 242GLY A 241ASP A 216ALA A 214SER A 288LEU A 291 | PLP A 962 (-4.8A)PLP A 962 (-4.3A)NoneNonePLP A 962 (-4.2A)None | 1.16A | 5x6yB-1tdjA:2.7 | 5x6yB-1tdjA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usv | HEAT SHOCK PROTEINHSP82 (Saccharomycescerevisiae) |
PF00183(HSP90) | 5 | VAL A 429GLY A 428ASP A 506ALA A 509LEU A 443 | None | 1.20A | 5x6yB-1usvA:2.1 | 5x6yB-1usvA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhc | NADH OXIDASE/NITRITE REDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2) | 5 | VAL A 6GLY A 7ALA A 75LEU A 230ASN A 227 | NoneFAD A 360 (-3.2A)FAD A 360 (-3.6A)FAD A 360 ( 4.3A)None | 0.68A | 5x6yB-1xhcA:3.1 | 5x6yB-1xhcA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhc | NADH OXIDASE/NITRITE REDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2) | 5 | VAL A 6GLY A 7LYS A 30ALA A 75ASN A 227 | NoneFAD A 360 (-3.2A)FAD A 360 (-4.7A)FAD A 360 (-3.6A)None | 0.80A | 5x6yB-1xhcA:3.1 | 5x6yB-1xhcA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xv9 | ORPHAN NUCLEARRECEPTOR NR1I3 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | VAL B 275GLY B 274ASP B 271SER B 192LEU B 193 | None | 1.05A | 5x6yB-1xv9B:undetectable | 5x6yB-1xv9B:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yub | RRNAMETHYLTRANSFERASE (Streptococcuspneumoniae) |
PF00398(RrnaAD) | 5 | VAL A 54GLU A 35ALA A 48LEU A 66ASN A 65 | None | 1.02A | 5x6yB-1yubA:3.1 | 5x6yB-1yubA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7s | HUMAN COXSACKIEVIRUSA21 (Enterovirus C) |
PF00073(Rhv) | 5 | VAL 2 124GLY 2 123ALA 2 206ASN 2 199ASN 2 203 | None | 1.10A | 5x6yB-1z7s2:undetectable | 5x6yB-1z7s2:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azn | PUTATIVE5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACILREDUCTASE (Methanocaldococcusjannaschii) |
PF01872(RibD_C) | 5 | VAL A 134GLY A 130GLU A 106ALA A 103LEU A 139 | NAP A2001 (-4.0A)NoneNoneNoneNone | 1.01A | 5x6yB-2aznA:undetectable | 5x6yB-2aznA:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi3 | PHOSPHOSERINEAMINOTRANSFERASE (Bacillusalcalophilus) |
PF00266(Aminotran_5) | 5 | VAL A 203GLY A 202ALA A 194SER A 243LEU A 247 | None | 1.15A | 5x6yB-2bi3A:undetectable | 5x6yB-2bi3A:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | FATTY OXIDATIONCOMPLEX ALPHASUBUNIT (Pseudomonasfragi) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | VAL A 153GLY A 151GLU A 120LEU A 271ASN A 89 | None | 1.18A | 5x6yB-2d3tA:2.2 | 5x6yB-2d3tA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT B (Staphylococcusaureus) |
PF02637(GatB_Yqey)PF02934(GatB_N) | 5 | VAL B 348GLY B 347GLU B 350LEU B 344ASN B 342 | None | 1.14A | 5x6yB-2f2aB:undetectable | 5x6yB-2f2aB:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fca | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Bacillussubtilis) |
PF02390(Methyltransf_4) | 5 | VAL A 45GLY A 46GLU A 69ALA A 97LEU A 130 | None K A 250 (-3.9A)NoneNoneNone | 0.93A | 5x6yB-2fcaA:3.1 | 5x6yB-2fcaA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fca | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Bacillussubtilis) |
PF02390(Methyltransf_4) | 5 | VAL A 45GLY A 46GLU A 69ASP A 96ALA A 97 | None K A 250 (-3.9A)NoneNoneNone | 1.09A | 5x6yB-2fcaA:3.1 | 5x6yB-2fcaA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 5 | VAL A 41GLY A 42GLU A 71ALA A 167LEU A 219 | FAD A 611 (-4.9A)FAD A 611 (-3.3A)FAD A 611 (-2.9A)FAD A 611 (-3.3A)FAD A 611 (-4.4A) | 0.74A | 5x6yB-2gmhA:undetectable | 5x6yB-2gmhA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hs5 | PUTATIVETRANSCRIPTIONALREGULATOR GNTR (Rhodococcusjostii) |
PF00392(GntR)PF07729(FCD) | 5 | VAL A 144GLY A 145ALA A 132LEU A 193ASN A 196 | None | 0.99A | 5x6yB-2hs5A:undetectable | 5x6yB-2hs5A:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p5u | UDP-GLUCOSE4-EPIMERASE (Thermusthermophilus) |
PF01370(Epimerase) | 5 | VAL A 166GLY A 236ALA A 230LEU A 168ASN A 239 | None | 0.89A | 5x6yB-2p5uA:2.3 | 5x6yB-2p5uA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 6 | VAL A 123GLY A 124GLU A 147ASP A 178ALA A 179LEU A 207 | NoneS4M A 501 (-3.4A)S4M A 501 (-2.7A)S4M A 501 (-3.3A)S4M A 501 (-3.5A)S4M A 501 (-4.4A) | 0.87A | 5x6yB-2pt6A:3.6 | 5x6yB-2pt6A:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7t | PROTEIN TRAI (Escherichiacoli) |
PF08751(TrwC) | 5 | GLY A 184GLU A 187SER A 176LEU A 175ASN A 164 | None | 1.12A | 5x6yB-2q7tA:undetectable | 5x6yB-2q7tA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qec | HISTONEACETYLTRANSFERASEHPA2 AND RELATEDACETYLTRANSFERASES (Corynebacteriumglutamicum) |
PF00583(Acetyltransf_1) | 5 | VAL A 141GLY A 140ALA A 65LEU A 145ASN A 147 | None | 0.94A | 5x6yB-2qecA:undetectable | 5x6yB-2qecA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhh | CG3027-PA (Drosophilamelanogaster) |
PF00795(CN_hydrolase) | 5 | LYS A 56ASP A 54SER A 330ASN A 10ASN A 8 | None | 1.18A | 5x6yB-2vhhA:undetectable | 5x6yB-2vhhA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wzr | POLYPROTEIN (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 5 | VAL 2 123ALA 2 156LEU 2 148ASN 2 149ASN 2 153 | None | 1.11A | 5x6yB-2wzr2:undetectable | 5x6yB-2wzr2:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7l | AGGLUTININ-LIKE ALS9PROTEIN (Candidaalbicans) |
PF11766(Candida_ALS_N) | 5 | VAL A 6GLY A 5ASP A 48LEU A 39ASN A 40 | None | 1.21A | 5x6yB-2y7lA:undetectable | 5x6yB-2y7lA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzw | ADP-RIBOSYLGLYCOHYDROLASE (Thermusthermophilus) |
PF03747(ADP_ribosyl_GH) | 5 | VAL A 255GLY A 256ALA A 227LEU A 248ASN A 247 | None | 1.09A | 5x6yB-2yzwA:undetectable | 5x6yB-2yzwA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8u | TATA-BOX-BINDINGPROTEIN (Methanocaldococcusjannaschii) |
PF00352(TBP) | 5 | VAL A 51GLY A 65ALA A 75LEU A 53ASN A 62 | None | 0.96A | 5x6yB-2z8uA:undetectable | 5x6yB-2z8uA:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9c | TRANSLATIONINITIATION FACTOREIF-2B, DELTASUBUNIT (Thermococcuskodakarensis) |
PF01008(IF-2B) | 5 | GLY A 23ALA A 29SER A 68LEU A 69ASN A 71 | None | 1.20A | 5x6yB-3a9cA:undetectable | 5x6yB-3a9cA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bus | METHYLTRANSFERASE (Lechevalieriaaerocolonigenes) |
PF08241(Methyltransf_11) | 5 | VAL A 68GLY A 69ASP A 119ALA A 120SER A 138 | NoneSAH A 274 (-3.1A)SAH A 274 (-3.6A)SAH A 274 (-3.5A)None | 0.83A | 5x6yB-3busA:2.3 | 5x6yB-3busA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed4 | ARYLSULFATASE (Escherichiacoli) |
PF00884(Sulfatase) | 5 | GLY A 212GLU A 240ASP A 293ALA A 294SER A 216 | None | 1.21A | 5x6yB-3ed4A:3.1 | 5x6yB-3ed4A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epc | PROTEIN VP2 (Enterovirus C) |
PF00073(Rhv) | 5 | VAL 2 124GLY 2 123ALA 2 206ASN 2 199ASN 2 203 | None | 1.08A | 5x6yB-3epc2:undetectable | 5x6yB-3epc2:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epd | PROTEIN VP2 (Enterovirus C) |
PF00073(Rhv) | 5 | VAL 2 124GLY 2 123ALA 2 205ASN 2 198ASN 2 202 | None | 1.11A | 5x6yB-3epd2:undetectable | 5x6yB-3epd2:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epf | PROTEIN VP2 (Enterovirus C) |
PF00073(Rhv) | 5 | VAL 2 124GLY 2 123ALA 2 205ASN 2 198ASN 2 202 | None | 1.10A | 5x6yB-3epf2:undetectable | 5x6yB-3epf2:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fes | ATP-DEPENDENT CLPENDOPEPTIDASE (Clostridioidesdifficile) |
PF02861(Clp_N) | 5 | VAL A 28GLY A 29GLU A 31ALA A 16SER A 83 | None | 1.12A | 5x6yB-3fesA:undetectable | 5x6yB-3fesA:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fut | DIMETHYLADENOSINETRANSFERASE (Thermusthermophilus) |
PF00398(RrnaAD) | 7 | VAL A 53GLY A 54GLU A 75LYS A 76ASP A 99ALA A 100LEU A 126 | None | 0.95A | 5x6yB-3futA:3.3 | 5x6yB-3futA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fut | DIMETHYLADENOSINETRANSFERASE (Thermusthermophilus) |
PF00398(RrnaAD) | 5 | VAL A 53GLY A 54GLU A 75LYS A 76LEU A 118 | None | 0.93A | 5x6yB-3futA:3.3 | 5x6yB-3futA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fwz | INNER MEMBRANEPROTEIN YBAL (Escherichiacoli) |
PF02254(TrkA_N) | 5 | VAL A 423GLY A 424GLU A 447ALA A 468LEU A 487 | AMP A 601 ( 4.9A)AMP A 601 (-3.5A)AMP A 601 (-2.8A)AMP A 601 (-3.9A)None | 1.09A | 5x6yB-3fwzA:4.0 | 5x6yB-3fwzA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljp | CHOLINE OXIDASE (Arthrobacterglobiformis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | VAL A 19GLY A 20GLU A 44ALA A 232LEU A 277 | NoneFDA A 547 (-3.2A)FDA A 547 (-2.7A)FDA A 547 (-3.6A)None | 0.68A | 5x6yB-3ljpA:undetectable | 5x6yB-3ljpA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lqy | PUTATIVEISOCHORISMATASEHYDROLASE (Oleispiraantarctica) |
PF00857(Isochorismatase) | 5 | VAL A 118GLY A 119ASP A 145ALA A 143LEU A 42 | None | 1.10A | 5x6yB-3lqyA:undetectable | 5x6yB-3lqyA:12.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moi | PROBABLEDEHYDROGENASE (Bordetellabronchiseptica) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | VAL A 142GLY A 143GLU A 308ALA A 310LEU A 312 | None | 1.17A | 5x6yB-3moiA:2.6 | 5x6yB-3moiA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nze | PUTATIVETRANSCRIPTIONALREGULATOR,SUGAR-BINDING FAMILY (Paenarthrobacteraurescens) |
PF04198(Sugar-bind) | 5 | VAL A 210GLY A 211ALA A 294LEU A 291ASN A 289 | None | 1.08A | 5x6yB-3nzeA:undetectable | 5x6yB-3nzeA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8l | 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE (Oryctolaguscuniculus) |
PF00365(PFK) | 5 | VAL A 115GLY A 160ALA A 125LEU A 113ASN A 157 | None | 1.17A | 5x6yB-3o8lA:undetectable | 5x6yB-3o8lA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pgv | HALOACIDDEHALOGENASE-LIKEHYDROLASE (Klebsiellapneumoniae) |
PF08282(Hydrolase_3) | 5 | GLY A 192ASP A 8ALA A 41SER A 190ASN A 217 | None CA A 267 ( 2.6A)NoneNoneEPE A 268 (-3.1A) | 1.20A | 5x6yB-3pgvA:2.5 | 5x6yB-3pgvA:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxp | ADP-L-GLYCERO-D-MANNOHEPTOSE-6-EPIMERASE (Helicobacterpylori) |
PF01370(Epimerase) | 5 | VAL A 182GLY A 249ALA A 242LEU A 184ASN A 252 | None | 1.02A | 5x6yB-3sxpA:2.5 | 5x6yB-3sxpA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqs | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE A (Coxiellaburnetii) |
PF00398(RrnaAD) | 5 | GLY A 40GLU A 61ASP A 86ALA A 87LEU A 115 | None | 0.84A | 5x6yB-3tqsA:5.1 | 5x6yB-3tqsA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uzu | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE A (Burkholderiapseudomallei) |
PF00398(RrnaAD) | 5 | GLY A 46GLU A 71ASP A 94ALA A 95LEU A 126 | None | 1.00A | 5x6yB-3uzuA:4.5 | 5x6yB-3uzuA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vyw | MNMC2 (Aquifexaeolicus) |
PF05430(Methyltransf_30) | 5 | GLY A 104GLU A 133LYS A 134ASP A 174ALA A 175 | SAM A 501 (-3.6A)SAM A 501 (-2.3A)SAM A 501 (-4.4A)SAM A 501 (-3.4A)SAM A 501 (-3.8A) | 0.84A | 5x6yB-3vywA:2.4 | 5x6yB-3vywA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vyw | MNMC2 (Aquifexaeolicus) |
PF05430(Methyltransf_30) | 5 | GLY A 104LYS A 134ASP A 174ALA A 175LEU A 203 | SAM A 501 (-3.6A)SAM A 501 (-4.4A)SAM A 501 (-3.4A)SAM A 501 (-3.8A)SAM A 501 (-4.6A) | 0.98A | 5x6yB-3vywA:2.4 | 5x6yB-3vywA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wbh | ALKALINE PHOSPHATASE (Halomonas sp.#593) |
PF00245(Alk_phosphatase) | 5 | VAL A 454GLY A 449ASP A 276ALA A 277LEU A 357 | None | 1.10A | 5x6yB-3wbhA:2.6 | 5x6yB-3wbhA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjp | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPE (Thermococcuskodakarensis) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | VAL A 163GLY A 164GLU A 305ASP A 309ALA A 308 | None | 1.12A | 5x6yB-3wjpA:undetectable | 5x6yB-3wjpA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 406GLY A 407ALA A 260SER A 385ASN A 437 | None | 0.92A | 5x6yB-4a0sA:undetectable | 5x6yB-4a0sA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bok | ALPHA-1,6-MANNANASE (Bacilluscirculans) |
PF03663(Glyco_hydro_76) | 5 | VAL A 253GLY A 254ALA A 268LEU A 265ASN A 261 | None | 1.19A | 5x6yB-4bokA:undetectable | 5x6yB-4bokA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c8y | CAS6A (Thermusthermophilus) |
PF10040(CRISPR_Cas6) | 5 | VAL A 223GLY A 224ALA A 218SER A 146LEU A 147 | None G C 26 ( 3.5A)None G C 26 ( 3.8A)None | 1.20A | 5x6yB-4c8yA:undetectable | 5x6yB-4c8yA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c98 | CAS6B (Thermusthermophilus) |
PF10040(CRISPR_Cas6) | 5 | VAL A 250GLY A 251ALA A 245SER A 167LEU A 168 | None | 1.14A | 5x6yB-4c98A:undetectable | 5x6yB-4c98A:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2i | LARGE T ANTIGEN (Macaca mulattapolyomavirus 1) |
PF06431(Polyoma_lg_T_C) | 5 | VAL A 625GLY A 624ALA A 389SER A 560LEU A 563 | None | 0.92A | 5x6yB-4e2iA:2.9 | 5x6yB-4e2iA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exp | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTOR (Mus musculus) |
PF00047(ig) | 5 | VAL X 195ALA X 167SER X 172LEU X 193ASN X 173 | None | 1.10A | 5x6yB-4expX:undetectable | 5x6yB-4expX:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f7a | PUTATIVEUNCHARACTERIZEDPROTEIN (Bacteroidesvulgatus) |
PF12741(SusD-like) | 5 | VAL A 390GLY A 389ASP A 401ALA A 402LEU A 406 | None | 1.06A | 5x6yB-4f7aA:undetectable | 5x6yB-4f7aA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fd7 | PUTATIVEARYLALKYLAMINEN-ACETYLTRANSFERASE7 (Aedes aegypti) |
PF00583(Acetyltransf_1) | 5 | VAL A 101GLY A 100ASP A 43ALA A 44LEU A 36 | NoneNoneIOD A 301 ( 4.6A)NoneNone | 1.01A | 5x6yB-4fd7A:undetectable | 5x6yB-4fd7A:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 5 | VAL A 25GLY A 445ASP A 454ALA A 450SER A 23 | None | 1.14A | 5x6yB-4fxsA:undetectable | 5x6yB-4fxsA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gdf | LARGE T ANTIGEN (Macaca mulattapolyomavirus 1) |
PF02217(T_Ag_DNA_bind)PF06431(Polyoma_lg_T_C) | 5 | VAL A 625GLY A 624ALA A 389SER A 560LEU A 563 | None | 0.87A | 5x6yB-4gdfA:2.8 | 5x6yB-4gdfA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvr | METHENYLTETRAHYDROMETHANOPTERINCYCLOHYDROLASE (Archaeoglobusfulgidus) |
PF02289(MCH) | 5 | VAL A 235GLY A 207GLU A 80ALA A 188LEU A 237 | None | 1.04A | 5x6yB-4gvrA:undetectable | 5x6yB-4gvrA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4id9 | SHORT-CHAINDEHYDROGENASE/REDUCTASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 5 | VAL A 155GLY A 248ALA A 239LEU A 157ASN A 251 | None | 1.09A | 5x6yB-4id9A:2.6 | 5x6yB-4id9A:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9v | POTASSIUM UPTAKEPROTEIN TRKA (Vibrioparahaemolyticus) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | VAL A 238GLY A 239GLU A 261ALA A 284ASN A 306 | NoneAGS A 502 (-3.3A)AGS A 502 (-2.4A)AGS A 502 (-3.2A)AGS A 502 (-2.8A) | 1.19A | 5x6yB-4j9vA:undetectable | 5x6yB-4j9vA:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9v | POTASSIUM UPTAKEPROTEIN TRKA (Vibrioparahaemolyticus) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | VAL A 238GLY A 239GLU A 261ASP A 283ALA A 284 | NoneAGS A 502 (-3.3A)AGS A 502 (-2.4A)AGS A 502 (-2.9A)AGS A 502 (-3.2A) | 0.76A | 5x6yB-4j9vA:undetectable | 5x6yB-4j9vA:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4knt | MULTICOPPER OXIDASETYPE 1 (Nitrosomonaseuropaea) |
PF07732(Cu-oxidase_3) | 5 | VAL A 118GLY A 117ASP A 258ALA A 259ASN A 244 | None | 1.06A | 5x6yB-4kntA:undetectable | 5x6yB-4kntA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ku4 | RAS-3 FROMCRYPHONECTRIAPARASITICA (Cryphonectriaparasitica) |
PF00071(Ras) | 5 | VAL A 140GLY A 141GLU A 170ALA A 182LEU A 27 | None | 1.06A | 5x6yB-4ku4A:undetectable | 5x6yB-4ku4A:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o29 | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Pyrobaculumaerophilum) |
PF01135(PCMT) | 5 | VAL A 79GLY A 80GLU A 104ASP A 132LEU A 204 | NoneSAH A 500 (-3.1A)SAH A 500 (-2.8A)SAH A 500 (-4.0A)SAH A 500 (-4.3A) | 1.07A | 5x6yB-4o29A:undetectable | 5x6yB-4o29A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oye | 425AA LONGHYPOTHETICAL PROTONGLUTAMATE SYMPORTPROTEIN (Pyrococcushorikoshii) |
PF00375(SDF) | 5 | VAL A 176GLU A 174SER A 171LEU A 168ASN A 170 | None | 1.20A | 5x6yB-4oyeA:undetectable | 5x6yB-4oyeA:19.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 5 | VAL A 79GLY A 80ASP A 130ALA A 131SER A 149 | NoneSAH A 301 (-2.7A)SAH A 301 (-2.7A)SAH A 301 (-3.5A)SAH A 301 (-4.7A) | 0.84A | 5x6yB-4pneA:5.5 | 5x6yB-4pneA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2c | CRISPR-ASSOCIATEDHELICASE CAS3 (Thermobaculumterrenum) |
PF00271(Helicase_C) | 5 | VAL A 414GLY A 413ALA A 429SER A 241ASN A 242 | NI A1003 ( 4.6A)NoneNone NI A1003 ( 4.8A)None | 0.82A | 5x6yB-4q2cA:undetectable | 5x6yB-4q2cA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q4y | COXSACKIEVIRUSCAPSID PROTEIN VP2 (Enterovirus C) |
PF00073(Rhv) | 5 | VAL 2 124GLY 2 123ALA 2 205ASN 2 198ASN 2 202 | None | 1.07A | 5x6yB-4q4y2:undetectable | 5x6yB-4q4y2:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rm7 | ACYL-COADEHYDROGENASE (Slackiaheliotrinireducens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | VAL A 330GLU A 329ALA A 254LEU A 292ASN A 294 | None | 1.06A | 5x6yB-4rm7A:undetectable | 5x6yB-4rm7A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 6 | VAL A 123GLY A 124GLU A 147ASP A 178ALA A 179LEU A 207 | NoneMTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)MTA A 401 (-3.6A)MTA A 401 (-4.4A) | 0.81A | 5x6yB-4uoeA:3.3 | 5x6yB-4uoeA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uwq | SULFUR OXIDATIONPROTEIN SOXB (Thermusthermophilus) |
PF02872(5_nucleotid_C) | 5 | VAL A 218GLY A 219ALA A 40LEU A 223ASN A 267 | None | 1.13A | 5x6yB-4uwqA:undetectable | 5x6yB-4uwqA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wmy | INTELECTIN-1 (Homo sapiens) |
no annotation | 5 | VAL A 256GLY A 258GLU A 230ASN A 242ASN A 248 | None | 1.05A | 5x6yB-4wmyA:undetectable | 5x6yB-4wmyA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzo | PUTATIVE ACYL-COAACYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 327GLY A 79ALA A 204SER A 41ASN A 42 | None | 1.19A | 5x6yB-4yzoA:undetectable | 5x6yB-4yzoA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zo6 | LIN1840 PROTEIN (Listeriainnocua) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | GLU A 373ALA A 375SER A 544LEU A 539ASN A 545 | None | 1.17A | 5x6yB-4zo6A:undetectable | 5x6yB-4zo6A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITGAMMA (Methanothermobactermarburgensis) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | VAL B 347GLY B 346GLU B 339ALA B 352LEU B 310 | None | 1.22A | 5x6yB-5a8rB:undetectable | 5x6yB-5a8rB:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amq | RNA POLYMERASE L (Californiaencephalitisorthobunyavirus) |
PF04196(Bunya_RdRp)PF15518(L_protein_N) | 5 | VAL A1347GLY A1348SER A1351LEU A1354ASN A1353 | None | 0.99A | 5x6yB-5amqA:undetectable | 5x6yB-5amqA:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czc | MALONYL-COA-[ACYL-CARRIER-PROTEIN]TRANSACYLASE (Streptomyceshalstedii) |
no annotation | 5 | VAL A 276GLY A 250ALA A 103SER A 279LEU A 280 | None | 1.17A | 5x6yB-5czcA:undetectable | 5x6yB-5czcA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ez7 | FLAVOENZYME PA4991 (Pseudomonasaeruginosa) |
PF01266(DAO) | 5 | VAL A 12GLY A 13GLU A 36SER A 204LEU A 203 | FAD A 401 (-4.7A)FAD A 401 (-3.3A)FAD A 401 (-2.8A)NoneNone | 1.10A | 5x6yB-5ez7A:undetectable | 5x6yB-5ez7A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6i | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | VAL A1920GLY A1921ASP A1979ALA A1976LEU A1911 | None | 0.98A | 5x6yB-5i6iA:undetectable | 5x6yB-5i6iA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic1 | TALIN-1 (Mus musculus) |
no annotation | 5 | VAL A1731GLY A1728GLU A1660ALA A1664LEU A1776 | None | 1.16A | 5x6yB-5ic1A:undetectable | 5x6yB-5ic1A:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jr3 | CARMINOMYCIN4-O-METHYLTRANSFERASE DNRK (Streptomycespeucetius) |
PF00891(Methyltransf_2) | 5 | VAL A 186GLY A 187GLU A 210ASP A 237ASN A 257 | NoneSAH A 401 (-3.9A)SAH A 401 (-2.8A)SAH A 401 (-3.7A)SAH A 401 (-4.2A) | 1.04A | 5x6yB-5jr3A:3.1 | 5x6yB-5jr3A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m77 | ALPHA-1,6-MANNANASE (Bacilluscirculans) |
PF03422(CBM_6)PF03663(Glyco_hydro_76) | 5 | VAL A 253GLY A 254ALA A 268LEU A 265ASN A 261 | NoneEDO A 605 (-3.5A)NoneNoneNone | 1.21A | 5x6yB-5m77A:undetectable | 5x6yB-5m77A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE, BETASUBUNIT (Methanotorrisformicicus) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | VAL B 348GLY B 347GLU B 340ALA B 353LEU B 311 | None | 1.21A | 5x6yB-5n28B:undetectable | 5x6yB-5n28B:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 9 | VAL C 209GLY C 210GLU C 230LYS C 231ASP C 471ALA C 472SER C 488LEU C 489ASN C 494 | None | 0.83A | 5x6yB-5x6xC:59.0 | 5x6yB-5x6xC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 8 | VAL C 209GLY C 210GLU C 230LYS C 231ASP C 471LEU C 489ASN C 491ASN C 494 | None | 0.85A | 5x6yB-5x6xC:59.0 | 5x6yB-5x6xC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xj6 | GLYCEROL-3-PHOSPHATEACYLTRANSFERASE (Aquifexaeolicus) |
no annotation | 5 | VAL A 33GLY A 34ALA A 46LEU A 30ASN A 37 | NoneNoneNoneNonePO4 A 306 (-3.2A) | 1.05A | 5x6yB-5xj6A:undetectable | 5x6yB-5xj6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yg7 | RIBOSE1,5-BISPHOSPHATEISOMERASE (Pyrococcushorikoshii) |
no annotation | 5 | GLY A 25ALA A 31SER A 70LEU A 71ASN A 73 | RI2 A 401 (-3.5A)NoneNoneNoneNone | 1.18A | 5x6yB-5yg7A:2.4 | 5x6yB-5yg7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2y | SOLUTE-BINDINGPERIPLASMIC PROTEINOF IRON/SIDEROPHOREABC TRANSPORTER (Yersinia pestis) |
no annotation | 5 | VAL A 253GLY A 252ALA A 240SER A 267LEU A 268 | None | 1.13A | 5x6yB-6b2yA:undetectable | 5x6yB-6b2yA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gh2 | LAMINARIBIOSEPHOSPHORYLASE (Paenibacillussp. YM1) |
no annotation | 5 | VAL A 60GLU A 58SER A 64LEU A 65ASN A 67 | None | 1.04A | 5x6yB-6gh2A:undetectable | 5x6yB-6gh2A:undetectable |