SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_B_SAMB901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dts DETHIOBIOTIN
SYNTHETASE


(Escherichia
coli)
PF13500
(AAA_26)
5 GLY A  35
ASP A 110
ALA A 109
SER A  62
LEU A  64
None
0.88A 5x6yB-1dtsA:
3.3
5x6yB-1dtsA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 VAL A  15
GLY A  16
GLU A  39
LYS A  40
ALA A 119
ASN A 277
None
FAD  A 462 (-3.4A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.1A)
FAD  A 462 (-4.0A)
None
0.72A 5x6yB-1ebdA:
2.7
5x6yB-1ebdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN


(Thermococcus
litoralis)
PF01547
(SBP_bac_1)
5 VAL A 188
GLY A 193
GLU A 211
ALA A 215
ASN A 208
None
1.11A 5x6yB-1eu8A:
undetectable
5x6yB-1eu8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE


(Escherichia
coli)
PF03275
(GLF)
PF13450
(NAD_binding_8)
5 VAL A   7
GLY A   8
GLU A  31
LYS A  32
ASP A 212
FAD  A 450 (-4.7A)
FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
0.74A 5x6yB-1i8tA:
2.0
5x6yB-1i8tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN


(Mus musculus)
PF02816
(Alpha_kinase)
5 GLY A1792
GLU A1672
LEU A1796
ASN A1795
ASN A1731
None
1.10A 5x6yB-1iahA:
undetectable
5x6yB-1iahA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Pyrococcus
furiosus)
PF01135
(PCMT)
5 VAL A  98
GLY A  99
GLU A 121
ASP A 148
LEU A 221
None
ADN  A 500 (-3.2A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.2A)
1.11A 5x6yB-1jg3A:
undetectable
5x6yB-1jg3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)


(Limulus
polyphemus)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
5 VAL A  84
GLY A  38
ALA A  80
LEU A  60
ASN A  36
None
1.06A 5x6yB-1llaA:
undetectable
5x6yB-1llaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG


(Staphylococcus
aureus)
PF02898
(NO_synthase)
5 VAL A 284
GLY A 283
ALA A 201
LEU A 102
ASN A  98
None
1.15A 5x6yB-1mjtA:
undetectable
5x6yB-1mjtA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus)
PF00491
(Arginase)
5 VAL A  96
ALA A  13
SER A 107
LEU A  80
ASN A  77
None
0.93A 5x6yB-1p8rA:
undetectable
5x6yB-1p8rA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F


(Elizabethkingia
meningoseptica)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
5 GLY A 203
ASP A 290
ALA A 291
ASN A 285
ASN A 284
None
1.17A 5x6yB-1pgsA:
undetectable
5x6yB-1pgsA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pov POLIOVIRUS NATIVE
EMPTY CAPSID (TYPE
1)


(Enterovirus C)
PF00073
(Rhv)
PF02226
(Pico_P1A)
5 VAL 0 193
GLY 0 192
ALA 0 275
ASN 0 268
ASN 0 272
None
1.22A 5x6yB-1pov0:
undetectable
5x6yB-1pov0:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE


(Escherichia
coli)
PF00291
(PALP)
PF00585
(Thr_dehydrat_C)
6 VAL A 242
GLY A 241
ASP A 216
ALA A 214
SER A 288
LEU A 291
PLP  A 962 (-4.8A)
PLP  A 962 (-4.3A)
None
None
PLP  A 962 (-4.2A)
None
1.16A 5x6yB-1tdjA:
2.7
5x6yB-1tdjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usv HEAT SHOCK PROTEIN
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
5 VAL A 429
GLY A 428
ASP A 506
ALA A 509
LEU A 443
None
1.20A 5x6yB-1usvA:
2.1
5x6yB-1usvA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE


(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
5 VAL A   6
GLY A   7
ALA A  75
LEU A 230
ASN A 227
None
FAD  A 360 (-3.2A)
FAD  A 360 (-3.6A)
FAD  A 360 ( 4.3A)
None
0.68A 5x6yB-1xhcA:
3.1
5x6yB-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE


(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
5 VAL A   6
GLY A   7
LYS A  30
ALA A  75
ASN A 227
None
FAD  A 360 (-3.2A)
FAD  A 360 (-4.7A)
FAD  A 360 (-3.6A)
None
0.80A 5x6yB-1xhcA:
3.1
5x6yB-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3


(Homo sapiens)
PF00104
(Hormone_recep)
5 VAL B 275
GLY B 274
ASP B 271
SER B 192
LEU B 193
None
1.05A 5x6yB-1xv9B:
undetectable
5x6yB-1xv9B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yub RRNA
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF00398
(RrnaAD)
5 VAL A  54
GLU A  35
ALA A  48
LEU A  66
ASN A  65
None
1.02A 5x6yB-1yubA:
3.1
5x6yB-1yubA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7s HUMAN COXSACKIEVIRUS
A21


(Enterovirus C)
PF00073
(Rhv)
5 VAL 2 124
GLY 2 123
ALA 2 206
ASN 2 199
ASN 2 203
None
1.10A 5x6yB-1z7s2:
undetectable
5x6yB-1z7s2:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE


(Methanocaldococcus
jannaschii)
PF01872
(RibD_C)
5 VAL A 134
GLY A 130
GLU A 106
ALA A 103
LEU A 139
NAP  A2001 (-4.0A)
None
None
None
None
1.01A 5x6yB-2aznA:
undetectable
5x6yB-2aznA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE


(Bacillus
alcalophilus)
PF00266
(Aminotran_5)
5 VAL A 203
GLY A 202
ALA A 194
SER A 243
LEU A 247
None
1.15A 5x6yB-2bi3A:
undetectable
5x6yB-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT


(Pseudomonas
fragi)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 VAL A 153
GLY A 151
GLU A 120
LEU A 271
ASN A  89
None
1.18A 5x6yB-2d3tA:
2.2
5x6yB-2d3tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Staphylococcus
aureus)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
5 VAL B 348
GLY B 347
GLU B 350
LEU B 344
ASN B 342
None
1.14A 5x6yB-2f2aB:
undetectable
5x6yB-2f2aB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE


(Bacillus
subtilis)
PF02390
(Methyltransf_4)
5 VAL A  45
GLY A  46
GLU A  69
ALA A  97
LEU A 130
None
K  A 250 (-3.9A)
None
None
None
0.93A 5x6yB-2fcaA:
3.1
5x6yB-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE


(Bacillus
subtilis)
PF02390
(Methyltransf_4)
5 VAL A  45
GLY A  46
GLU A  69
ASP A  96
ALA A  97
None
K  A 250 (-3.9A)
None
None
None
1.09A 5x6yB-2fcaA:
3.1
5x6yB-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
5 VAL A  41
GLY A  42
GLU A  71
ALA A 167
LEU A 219
FAD  A 611 (-4.9A)
FAD  A 611 (-3.3A)
FAD  A 611 (-2.9A)
FAD  A 611 (-3.3A)
FAD  A 611 (-4.4A)
0.74A 5x6yB-2gmhA:
undetectable
5x6yB-2gmhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR


(Rhodococcus
jostii)
PF00392
(GntR)
PF07729
(FCD)
5 VAL A 144
GLY A 145
ALA A 132
LEU A 193
ASN A 196
None
0.99A 5x6yB-2hs5A:
undetectable
5x6yB-2hs5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE


(Thermus
thermophilus)
PF01370
(Epimerase)
5 VAL A 166
GLY A 236
ALA A 230
LEU A 168
ASN A 239
None
0.89A 5x6yB-2p5uA:
2.3
5x6yB-2p5uA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
6 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
0.87A 5x6yB-2pt6A:
3.6
5x6yB-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7t PROTEIN TRAI

(Escherichia
coli)
PF08751
(TrwC)
5 GLY A 184
GLU A 187
SER A 176
LEU A 175
ASN A 164
None
1.12A 5x6yB-2q7tA:
undetectable
5x6yB-2q7tA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES


(Corynebacterium
glutamicum)
PF00583
(Acetyltransf_1)
5 VAL A 141
GLY A 140
ALA A  65
LEU A 145
ASN A 147
None
0.94A 5x6yB-2qecA:
undetectable
5x6yB-2qecA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster)
PF00795
(CN_hydrolase)
5 LYS A  56
ASP A  54
SER A 330
ASN A  10
ASN A   8
None
1.18A 5x6yB-2vhhA:
undetectable
5x6yB-2vhhA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 VAL 2 123
ALA 2 156
LEU 2 148
ASN 2 149
ASN 2 153
None
1.11A 5x6yB-2wzr2:
undetectable
5x6yB-2wzr2:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7l AGGLUTININ-LIKE ALS9
PROTEIN


(Candida
albicans)
PF11766
(Candida_ALS_N)
5 VAL A   6
GLY A   5
ASP A  48
LEU A  39
ASN A  40
None
1.21A 5x6yB-2y7lA:
undetectable
5x6yB-2y7lA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE


(Thermus
thermophilus)
PF03747
(ADP_ribosyl_GH)
5 VAL A 255
GLY A 256
ALA A 227
LEU A 248
ASN A 247
None
1.09A 5x6yB-2yzwA:
undetectable
5x6yB-2yzwA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8u TATA-BOX-BINDING
PROTEIN


(Methanocaldococcus
jannaschii)
PF00352
(TBP)
5 VAL A  51
GLY A  65
ALA A  75
LEU A  53
ASN A  62
None
0.96A 5x6yB-2z8uA:
undetectable
5x6yB-2z8uA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT


(Thermococcus
kodakarensis)
PF01008
(IF-2B)
5 GLY A  23
ALA A  29
SER A  68
LEU A  69
ASN A  71
None
1.20A 5x6yB-3a9cA:
undetectable
5x6yB-3a9cA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes)
PF08241
(Methyltransf_11)
5 VAL A  68
GLY A  69
ASP A 119
ALA A 120
SER A 138
None
SAH  A 274 (-3.1A)
SAH  A 274 (-3.6A)
SAH  A 274 (-3.5A)
None
0.83A 5x6yB-3busA:
2.3
5x6yB-3busA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli)
PF00884
(Sulfatase)
5 GLY A 212
GLU A 240
ASP A 293
ALA A 294
SER A 216
None
1.21A 5x6yB-3ed4A:
3.1
5x6yB-3ed4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C)
PF00073
(Rhv)
5 VAL 2 124
GLY 2 123
ALA 2 206
ASN 2 199
ASN 2 203
None
1.08A 5x6yB-3epc2:
undetectable
5x6yB-3epc2:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C)
PF00073
(Rhv)
5 VAL 2 124
GLY 2 123
ALA 2 205
ASN 2 198
ASN 2 202
None
1.11A 5x6yB-3epd2:
undetectable
5x6yB-3epd2:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C)
PF00073
(Rhv)
5 VAL 2 124
GLY 2 123
ALA 2 205
ASN 2 198
ASN 2 202
None
1.10A 5x6yB-3epf2:
undetectable
5x6yB-3epf2:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE


(Clostridioides
difficile)
PF02861
(Clp_N)
5 VAL A  28
GLY A  29
GLU A  31
ALA A  16
SER A  83
None
1.12A 5x6yB-3fesA:
undetectable
5x6yB-3fesA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE


(Thermus
thermophilus)
PF00398
(RrnaAD)
7 VAL A  53
GLY A  54
GLU A  75
LYS A  76
ASP A  99
ALA A 100
LEU A 126
None
0.95A 5x6yB-3futA:
3.3
5x6yB-3futA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE


(Thermus
thermophilus)
PF00398
(RrnaAD)
5 VAL A  53
GLY A  54
GLU A  75
LYS A  76
LEU A 118
None
0.93A 5x6yB-3futA:
3.3
5x6yB-3futA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL


(Escherichia
coli)
PF02254
(TrkA_N)
5 VAL A 423
GLY A 424
GLU A 447
ALA A 468
LEU A 487
AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
AMP  A 601 (-3.9A)
None
1.09A 5x6yB-3fwzA:
4.0
5x6yB-3fwzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 VAL A  19
GLY A  20
GLU A  44
ALA A 232
LEU A 277
None
FDA  A 547 (-3.2A)
FDA  A 547 (-2.7A)
FDA  A 547 (-3.6A)
None
0.68A 5x6yB-3ljpA:
undetectable
5x6yB-3ljpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE


(Oleispira
antarctica)
PF00857
(Isochorismatase)
5 VAL A 118
GLY A 119
ASP A 145
ALA A 143
LEU A  42
None
1.10A 5x6yB-3lqyA:
undetectable
5x6yB-3lqyA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE


(Bordetella
bronchiseptica)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 VAL A 142
GLY A 143
GLU A 308
ALA A 310
LEU A 312
None
1.17A 5x6yB-3moiA:
2.6
5x6yB-3moiA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY


(Paenarthrobacter
aurescens)
PF04198
(Sugar-bind)
5 VAL A 210
GLY A 211
ALA A 294
LEU A 291
ASN A 289
None
1.08A 5x6yB-3nzeA:
undetectable
5x6yB-3nzeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
5 VAL A 115
GLY A 160
ALA A 125
LEU A 113
ASN A 157
None
1.17A 5x6yB-3o8lA:
undetectable
5x6yB-3o8lA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Klebsiella
pneumoniae)
PF08282
(Hydrolase_3)
5 GLY A 192
ASP A   8
ALA A  41
SER A 190
ASN A 217
None
CA  A 267 ( 2.6A)
None
None
EPE  A 268 (-3.1A)
1.20A 5x6yB-3pgvA:
2.5
5x6yB-3pgvA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE


(Helicobacter
pylori)
PF01370
(Epimerase)
5 VAL A 182
GLY A 249
ALA A 242
LEU A 184
ASN A 252
None
1.02A 5x6yB-3sxpA:
2.5
5x6yB-3sxpA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Coxiella
burnetii)
PF00398
(RrnaAD)
5 GLY A  40
GLU A  61
ASP A  86
ALA A  87
LEU A 115
None
0.84A 5x6yB-3tqsA:
5.1
5x6yB-3tqsA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Burkholderia
pseudomallei)
PF00398
(RrnaAD)
5 GLY A  46
GLU A  71
ASP A  94
ALA A  95
LEU A 126
None
1.00A 5x6yB-3uzuA:
4.5
5x6yB-3uzuA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus)
PF05430
(Methyltransf_30)
5 GLY A 104
GLU A 133
LYS A 134
ASP A 174
ALA A 175
SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
0.84A 5x6yB-3vywA:
2.4
5x6yB-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus)
PF05430
(Methyltransf_30)
5 GLY A 104
LYS A 134
ASP A 174
ALA A 175
LEU A 203
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.6A)
0.98A 5x6yB-3vywA:
2.4
5x6yB-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593)
PF00245
(Alk_phosphatase)
5 VAL A 454
GLY A 449
ASP A 276
ALA A 277
LEU A 357
None
1.10A 5x6yB-3wbhA:
2.6
5x6yB-3wbhA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE


(Thermococcus
kodakarensis)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 VAL A 163
GLY A 164
GLU A 305
ASP A 309
ALA A 308
None
1.12A 5x6yB-3wjpA:
undetectable
5x6yB-3wjpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E


(Streptomyces
cinnabarigriseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A 406
GLY A 407
ALA A 260
SER A 385
ASN A 437
None
0.92A 5x6yB-4a0sA:
undetectable
5x6yB-4a0sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans)
PF03663
(Glyco_hydro_76)
5 VAL A 253
GLY A 254
ALA A 268
LEU A 265
ASN A 261
None
1.19A 5x6yB-4bokA:
undetectable
5x6yB-4bokA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8y CAS6A

(Thermus
thermophilus)
PF10040
(CRISPR_Cas6)
5 VAL A 223
GLY A 224
ALA A 218
SER A 146
LEU A 147
None
G  C  26 ( 3.5A)
None
G  C  26 ( 3.8A)
None
1.20A 5x6yB-4c8yA:
undetectable
5x6yB-4c8yA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c98 CAS6B

(Thermus
thermophilus)
PF10040
(CRISPR_Cas6)
5 VAL A 250
GLY A 251
ALA A 245
SER A 167
LEU A 168
None
1.14A 5x6yB-4c98A:
undetectable
5x6yB-4c98A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1)
PF06431
(Polyoma_lg_T_C)
5 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
None
0.92A 5x6yB-4e2iA:
2.9
5x6yB-4e2iA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR


(Mus musculus)
PF00047
(ig)
5 VAL X 195
ALA X 167
SER X 172
LEU X 193
ASN X 173
None
1.10A 5x6yB-4expX:
undetectable
5x6yB-4expX:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN


(Bacteroides
vulgatus)
PF12741
(SusD-like)
5 VAL A 390
GLY A 389
ASP A 401
ALA A 402
LEU A 406
None
1.06A 5x6yB-4f7aA:
undetectable
5x6yB-4f7aA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7


(Aedes aegypti)
PF00583
(Acetyltransf_1)
5 VAL A 101
GLY A 100
ASP A  43
ALA A  44
LEU A  36
None
None
IOD  A 301 ( 4.6A)
None
None
1.01A 5x6yB-4fd7A:
undetectable
5x6yB-4fd7A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
PF00571
(CBS)
5 VAL A  25
GLY A 445
ASP A 454
ALA A 450
SER A  23
None
1.14A 5x6yB-4fxsA:
undetectable
5x6yB-4fxsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1)
PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C)
5 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
None
0.87A 5x6yB-4gdfA:
2.8
5x6yB-4gdfA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE


(Archaeoglobus
fulgidus)
PF02289
(MCH)
5 VAL A 235
GLY A 207
GLU A  80
ALA A 188
LEU A 237
None
1.04A 5x6yB-4gvrA:
undetectable
5x6yB-4gvrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Agrobacterium
fabrum)
PF01370
(Epimerase)
5 VAL A 155
GLY A 248
ALA A 239
LEU A 157
ASN A 251
None
1.09A 5x6yB-4id9A:
2.6
5x6yB-4id9A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA


(Vibrio
parahaemolyticus)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
5 VAL A 238
GLY A 239
GLU A 261
ALA A 284
ASN A 306
None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-3.2A)
AGS  A 502 (-2.8A)
1.19A 5x6yB-4j9vA:
undetectable
5x6yB-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA


(Vibrio
parahaemolyticus)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
5 VAL A 238
GLY A 239
GLU A 261
ASP A 283
ALA A 284
None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
0.76A 5x6yB-4j9vA:
undetectable
5x6yB-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1


(Nitrosomonas
europaea)
PF07732
(Cu-oxidase_3)
5 VAL A 118
GLY A 117
ASP A 258
ALA A 259
ASN A 244
None
1.06A 5x6yB-4kntA:
undetectable
5x6yB-4kntA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA


(Cryphonectria
parasitica)
PF00071
(Ras)
5 VAL A 140
GLY A 141
GLU A 170
ALA A 182
LEU A  27
None
1.06A 5x6yB-4ku4A:
undetectable
5x6yB-4ku4A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o29 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Pyrobaculum
aerophilum)
PF01135
(PCMT)
5 VAL A  79
GLY A  80
GLU A 104
ASP A 132
LEU A 204
None
SAH  A 500 (-3.1A)
SAH  A 500 (-2.8A)
SAH  A 500 (-4.0A)
SAH  A 500 (-4.3A)
1.07A 5x6yB-4o29A:
undetectable
5x6yB-4o29A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN


(Pyrococcus
horikoshii)
PF00375
(SDF)
5 VAL A 176
GLU A 174
SER A 171
LEU A 168
ASN A 170
None
1.20A 5x6yB-4oyeA:
undetectable
5x6yB-4oyeA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
5 VAL A  79
GLY A  80
ASP A 130
ALA A 131
SER A 149
None
SAH  A 301 (-2.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.7A)
0.84A 5x6yB-4pneA:
5.5
5x6yB-4pneA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3


(Thermobaculum
terrenum)
PF00271
(Helicase_C)
5 VAL A 414
GLY A 413
ALA A 429
SER A 241
ASN A 242
NI  A1003 ( 4.6A)
None
None
NI  A1003 ( 4.8A)
None
0.82A 5x6yB-4q2cA:
undetectable
5x6yB-4q2cA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2


(Enterovirus C)
PF00073
(Rhv)
5 VAL 2 124
GLY 2 123
ALA 2 205
ASN 2 198
ASN 2 202
None
1.07A 5x6yB-4q4y2:
undetectable
5x6yB-4q4y2:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm7 ACYL-COA
DEHYDROGENASE


(Slackia
heliotrinireducens)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 VAL A 330
GLU A 329
ALA A 254
LEU A 292
ASN A 294
None
1.06A 5x6yB-4rm7A:
undetectable
5x6yB-4rm7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
6 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
None
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
MTA  A 401 (-4.4A)
0.81A 5x6yB-4uoeA:
3.3
5x6yB-4uoeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB


(Thermus
thermophilus)
PF02872
(5_nucleotid_C)
5 VAL A 218
GLY A 219
ALA A  40
LEU A 223
ASN A 267
None
1.13A 5x6yB-4uwqA:
undetectable
5x6yB-4uwqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens)
no annotation 5 VAL A 256
GLY A 258
GLU A 230
ASN A 242
ASN A 248
None
1.05A 5x6yB-4wmyA:
undetectable
5x6yB-4wmyA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 VAL A 327
GLY A  79
ALA A 204
SER A  41
ASN A  42
None
1.19A 5x6yB-4yzoA:
undetectable
5x6yB-4yzoA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 GLU A 373
ALA A 375
SER A 544
LEU A 539
ASN A 545
None
1.17A 5x6yB-4zo6A:
undetectable
5x6yB-4zo6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA


(Methanothermobacter
marburgensis)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 VAL B 347
GLY B 346
GLU B 339
ALA B 352
LEU B 310
None
1.22A 5x6yB-5a8rB:
undetectable
5x6yB-5a8rB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
5 VAL A1347
GLY A1348
SER A1351
LEU A1354
ASN A1353
None
0.99A 5x6yB-5amqA:
undetectable
5x6yB-5amqA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE


(Streptomyces
halstedii)
no annotation 5 VAL A 276
GLY A 250
ALA A 103
SER A 279
LEU A 280
None
1.17A 5x6yB-5czcA:
undetectable
5x6yB-5czcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa)
PF01266
(DAO)
5 VAL A  12
GLY A  13
GLU A  36
SER A 204
LEU A 203
FAD  A 401 (-4.7A)
FAD  A 401 (-3.3A)
FAD  A 401 (-2.8A)
None
None
1.10A 5x6yB-5ez7A:
undetectable
5x6yB-5ez7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 VAL A1920
GLY A1921
ASP A1979
ALA A1976
LEU A1911
None
0.98A 5x6yB-5i6iA:
undetectable
5x6yB-5i6iA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus)
no annotation 5 VAL A1731
GLY A1728
GLU A1660
ALA A1664
LEU A1776
None
1.16A 5x6yB-5ic1A:
undetectable
5x6yB-5ic1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK


(Streptomyces
peucetius)
PF00891
(Methyltransf_2)
5 VAL A 186
GLY A 187
GLU A 210
ASP A 237
ASN A 257
None
SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-4.2A)
1.04A 5x6yB-5jr3A:
3.1
5x6yB-5jr3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans)
PF03422
(CBM_6)
PF03663
(Glyco_hydro_76)
5 VAL A 253
GLY A 254
ALA A 268
LEU A 265
ASN A 261
None
EDO  A 605 (-3.5A)
None
None
None
1.21A 5x6yB-5m77A:
undetectable
5x6yB-5m77A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT


(Methanotorris
formicicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
None
1.21A 5x6yB-5n28B:
undetectable
5x6yB-5n28B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 9 VAL C 209
GLY C 210
GLU C 230
LYS C 231
ASP C 471
ALA C 472
SER C 488
LEU C 489
ASN C 494
None
0.83A 5x6yB-5x6xC:
59.0
5x6yB-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 8 VAL C 209
GLY C 210
GLU C 230
LYS C 231
ASP C 471
LEU C 489
ASN C 491
ASN C 494
None
0.85A 5x6yB-5x6xC:
59.0
5x6yB-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE


(Aquifex
aeolicus)
no annotation 5 VAL A  33
GLY A  34
ALA A  46
LEU A  30
ASN A  37
None
None
None
None
PO4  A 306 (-3.2A)
1.05A 5x6yB-5xj6A:
undetectable
5x6yB-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE


(Pyrococcus
horikoshii)
no annotation 5 GLY A  25
ALA A  31
SER A  70
LEU A  71
ASN A  73
RI2  A 401 (-3.5A)
None
None
None
None
1.18A 5x6yB-5yg7A:
2.4
5x6yB-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER


(Yersinia pestis)
no annotation 5 VAL A 253
GLY A 252
ALA A 240
SER A 267
LEU A 268
None
1.13A 5x6yB-6b2yA:
undetectable
5x6yB-6b2yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE


(Paenibacillus
sp. YM1)
no annotation 5 VAL A  60
GLU A  58
SER A  64
LEU A  65
ASN A  67
None
1.04A 5x6yB-6gh2A:
undetectable
5x6yB-6gh2A:
undetectable