SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_A_SAMA902_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR

(Homo sapiens) 		PF00041
(fn3) 		3 TYR A 354
ASP A 350
ASP A 352
 None
 0.73A 5x6yA-1egjA:
undetectable		 5x6yA-1egjA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		3 TYR A  90
ASP A  92
ASP A  54
 None
 0.70A 5x6yA-1gfnA:
undetectable		 5x6yA-1gfnA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pi2 BOWMAN-BIRK
INHIBITOR (PI-II)

(Glycine max) 		PF00228
(Bowman-Birk_leg) 		3 TYR A  57
ASP A  51
ASP A  33
 None
 0.75A 5x6yA-1pi2A:
undetectable		 5x6yA-1pi2A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF00878
(CIMR) 		3 TYR A  28
ASP A  51
ASP A  21
 None
 0.73A 5x6yA-1q25A:
undetectable		 5x6yA-1q25A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		3 TYR A  78
ASP A 439
ASP A 444
 None
 0.64A 5x6yA-1w18A:
undetectable		 5x6yA-1w18A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		3 TYR A  71
ASP A  93
ASP A  69
 None
 0.57A 5x6yA-1yggA:
undetectable		 5x6yA-1yggA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		3 TYR A 155
ASP A  58
ASP A 127
 None
 0.84A 5x6yA-2fpoA:
7.4		 5x6yA-2fpoA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		3 TYR A 143
ASP A 145
ASP A 142
 None
 0.82A 5x6yA-2hz7A:
undetectable		 5x6yA-2hz7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		3 TYR A 195
ASP A 224
ASP A 265
 None
 0.28A 5x6yA-2jh9A:
15.7		 5x6yA-2jh9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5q HYPOTHETICAL
MEMBRANE ASSOCIATED
PROTEIN BCR97A

(Bacillus cereus) 		PF06486
(DUF1093) 		3 TYR A  11
ASP A  45
ASP A   9
 None
 0.84A 5x6yA-2k5qA:
undetectable		 5x6yA-2k5qA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0m LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		3 TYR A 109
ASP A  58
ASP A 106
 None
 0.55A 5x6yA-2n0mA:
undetectable		 5x6yA-2n0mA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbi HEP200 PROTEIN

(Cylindrotheca
fusiformis) 		no annotation 3 TYR A 307
ASP A 309
ASP A 357
 None
 0.85A 5x6yA-2nbiA:
undetectable		 5x6yA-2nbiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvm FDXN ELEMENT
EXCISION CONTROLLING
FACTOR XISI

(Trichormus
variabilis) 		PF08869
(XisI) 		3 TYR A  55
ASP A  49
ASP A  53
 None
 0.82A 5x6yA-2nvmA:
undetectable		 5x6yA-2nvmA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus) 		PF13609
(Porin_4) 		3 TYR A 232
ASP A 203
ASP A 253
 C8E  A 548 (-4.8A)
None
None
 0.69A 5x6yA-2porA:
undetectable		 5x6yA-2porA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 TYR A 374
ASP A 415
ASP A 381
 None
 0.76A 5x6yA-2pwhA:
undetectable		 5x6yA-2pwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		3 TYR A 215
ASP A 231
ASP A 341
 None
 0.86A 5x6yA-2py6A:
6.0		 5x6yA-2py6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1y FAB, ANTIBODY
FRAGMENT (IGG1K),
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR B  32
ASP B  95
ASP B  97
 None
 0.83A 5x6yA-2r1yB:
undetectable		 5x6yA-2r1yB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v91 STRICTOSIDINE
SYNTHASE

(Rauvolfia
serpentina) 		PF03088
(Str_synth) 		3 TYR A 163
ASP A 193
ASP A 156
 None
 0.73A 5x6yA-2v91A:
undetectable		 5x6yA-2v91A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 TYR D 820
ASP D 873
ASP D 878
 None
 0.68A 5x6yA-2vnuD:
undetectable		 5x6yA-2vnuD:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 TYR A  66
ASP A  95
ASP A 138
 SAH  A 400 (-4.6A)
SAH  A 400 (-2.6A)
SAH  A 400 (-3.7A)
 0.14A 5x6yA-2vp3A:
3.1		 5x6yA-2vp3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  83
ASP A  40
ASP A  76
 None
 0.75A 5x6yA-2w5hA:
undetectable		 5x6yA-2w5hA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 TYR A 680
ASP A 675
ASP A 644
 None
 0.83A 5x6yA-2wghA:
undetectable		 5x6yA-2wghA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqk 5'-NUCLEOTIDASE SURE

(Aquifex
aeolicus) 		PF01975
(SurE) 		3 TYR A  62
ASP A  58
ASP A  60
 None
 0.83A 5x6yA-2wqkA:
2.4		 5x6yA-2wqkA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 TYR A 192
ASP A  52
ASP A 125
 None
None
ZN  A 902 (-3.5A)
 0.86A 5x6yA-2wyhA:
undetectable		 5x6yA-2wyhA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		3 TYR A 350
ASP A 148
ASP A 352
 None
 0.62A 5x6yA-2xdqA:
3.0		 5x6yA-2xdqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yop PROTEIN FAM3B

(Mus musculus) 		PF15711
(ILEI) 		3 TYR A  87
ASP A 157
ASP A  85
 None
GOL  A1192 (-3.0A)
None
 0.74A 5x6yA-2yopA:
undetectable		 5x6yA-2yopA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 TYR A 451
ASP A 405
ASP A 453
 None
 0.59A 5x6yA-2z63A:
undetectable		 5x6yA-2z63A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 TYR A 451
ASP A 405
ASP A 453
 None
 0.59A 5x6yA-2z66A:
undetectable		 5x6yA-2z66A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Mus musculus) 		PF02182
(SAD_SRA) 		3 TYR A 563
ASP A 588
ASP A 560
 None
 0.83A 5x6yA-2zkgA:
undetectable		 5x6yA-2zkgA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		3 TYR A 235
ASP A 291
ASP A 327
 None
 0.79A 5x6yA-3b4yA:
2.2		 5x6yA-3b4yA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 253
ASP A 216
ASP A 249
 None
 0.86A 5x6yA-3bewA:
undetectable		 5x6yA-3bewA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum) 		PF05448
(AXE1) 		3 TYR A  60
ASP A 115
ASP A  58
 None
 0.68A 5x6yA-3fcyA:
undetectable		 5x6yA-3fcyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frm UNCHARACTERIZED
CONSERVED PROTEIN

(Staphylococcus
epidermidis) 		PF13673
(Acetyltransf_10) 		3 TYR A  10
ASP A 177
ASP A  12
 None
 0.78A 5x6yA-3frmA:
undetectable		 5x6yA-3frmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 TYR A 451
ASP A 405
ASP A 453
 None
 0.62A 5x6yA-3fxiA:
undetectable		 5x6yA-3fxiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		3 TYR A  88
ASP A  86
ASP A  40
 None
 0.84A 5x6yA-3g6sA:
2.6		 5x6yA-3g6sA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		3 TYR A 293
ASP A 306
ASP A 286
 None
EDO  A   7 (-4.2A)
None
 0.63A 5x6yA-3hbcA:
undetectable		 5x6yA-3hbcA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhj MUTATOR MUTT PROTEIN

(Bartonella
henselae) 		PF14815
(NUDIX_4) 		3 TYR A 140
ASP A 138
ASP A 136
 None
 0.82A 5x6yA-3hhjA:
undetectable		 5x6yA-3hhjA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj9 OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		PF00881
(Nitroreductase) 		3 TYR A 106
ASP A  94
ASP A 107
 None
 0.85A 5x6yA-3hj9A:
undetectable		 5x6yA-3hj9A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		3 TYR A 102
ASP A  90
ASP A 103
 None
 0.82A 5x6yA-3hoiA:
undetectable		 5x6yA-3hoiA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		3 TYR B1129
ASP B1128
ASP B1130
 None
 0.83A 5x6yA-3k70B:
2.8		 5x6yA-3k70B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 TYR A 177
ASP A 190
ASP A 169
 None
ZN  A 519 (-2.5A)
EDO  A  11 ( 4.2A)
 0.75A 5x6yA-3kyaA:
undetectable		 5x6yA-3kyaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		3 TYR A  79
ASP A 114
ASP A  83
 None
 0.79A 5x6yA-3li9A:
undetectable		 5x6yA-3li9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 TYR A 241
ASP A 267
ASP A 181
 None
 0.82A 5x6yA-3lv4A:
undetectable		 5x6yA-3lv4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 3 TYR B 330
ASP B 344
ASP B 342
 None
 0.67A 5x6yA-3ozvB:
2.1		 5x6yA-3ozvB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 253
ASP A 216
ASP A 249
 None
 0.74A 5x6yA-3p77A:
undetectable		 5x6yA-3p77A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc9 HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 TYR A 180
ASP A 192
ASP A 172
 None
 0.86A 5x6yA-3tc9A:
undetectable		 5x6yA-3tc9A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 TYR A1167
ASP A1420
ASP A1157
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
 0.84A 5x6yA-3topA:
undetectable		 5x6yA-3topA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		3 TYR A 137
ASP A 287
ASP A 130
 None
 0.77A 5x6yA-3vh1A:
2.8		 5x6yA-3vh1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		3 TYR A 133
ASP A 272
ASP A 126
 None
 0.80A 5x6yA-3vx6A:
undetectable		 5x6yA-3vx6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 TYR A 288
ASP A 284
ASP A 286
 None
 0.73A 5x6yA-3w1gA:
undetectable		 5x6yA-3w1gA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a04 T-BOX TRANSCRIPTION
FACTOR TBX1

(Homo sapiens) 		PF00907
(T-box) 		3 TYR A 245
ASP A 155
ASP A 151
 None
 0.86A 5x6yA-4a04A:
undetectable		 5x6yA-4a04A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 3 TYR C 896
ASP C 903
ASP C 853
 None
 0.69A 5x6yA-4aq1C:
undetectable		 5x6yA-4aq1C:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqs LAMININ SUBUNIT
BETA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 TYR A 414
ASP A 412
ASP A 416
 None
 0.79A 5x6yA-4aqsA:
undetectable		 5x6yA-4aqsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		3 TYR A 243
ASP A 124
ASP A 294
 None
 0.84A 5x6yA-4bokA:
undetectable		 5x6yA-4bokA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 TYR A 237
ASP A 263
ASP A 177
 None
 0.79A 5x6yA-4cotA:
undetectable		 5x6yA-4cotA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		3 TYR A 187
ASP A 107
ASP A 112
 None
 0.70A 5x6yA-4d1iA:
undetectable		 5x6yA-4d1iA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgc NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Bacillus
subtilis) 		PF14489
(QueF) 		3 TYR A  85
ASP A  28
ASP A 106
 None
 0.82A 5x6yA-4fgcA:
undetectable		 5x6yA-4fgcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		3 TYR A 138
ASP A 156
ASP A 136
 None
 0.85A 5x6yA-4jo8A:
undetectable		 5x6yA-4jo8A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		3 TYR A  43
ASP A  41
ASP A  37
 None
 0.85A 5x6yA-4jp0A:
undetectable		 5x6yA-4jp0A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 TYR A 387
ASP A 421
ASP A 314
 None
 0.76A 5x6yA-4kcaA:
undetectable		 5x6yA-4kcaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kys THIAMINE
PYRIDINYLASE I

(Clostridium
botulinum) 		PF01547
(SBP_bac_1) 		3 TYR A  46
ASP A  78
ASP A  94
 VIB  A 501 (-4.4A)
None
VIB  A 501 (-3.4A)
 0.82A 5x6yA-4kysA:
undetectable		 5x6yA-4kysA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		3 TYR A  71
ASP A  74
ASP A  77
 None
 0.84A 5x6yA-4ovkA:
undetectable		 5x6yA-4ovkA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		3 TYR A 237
ASP A 199
ASP A 239
 None
 0.69A 5x6yA-4ow2A:
undetectable		 5x6yA-4ow2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		3 TYR A 277
ASP A 239
ASP A 279
 None
 0.73A 5x6yA-4ow2A:
undetectable		 5x6yA-4ow2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		3 TYR A 154
ASP A  49
ASP A 163
 None
 0.81A 5x6yA-4oy4A:
undetectable		 5x6yA-4oy4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA

(Homo sapiens;
Sus scrofa) 		PF00076
(RRM_1)
PF12220
(U1snRNP70_N) 		3 TYR B 226
ASP B 230
ASP B 242
 None
None
U  V  95 ( 3.8A)
 0.84A 5x6yA-4pkdB:
undetectable		 5x6yA-4pkdB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN

(Pseudomonas
putida) 		PF13557
(Phenol_MetA_deg) 		3 TYR A 144
ASP A 155
ASP A 108
 C8E  A 301 (-3.6A)
None
C8E  A 301 (-4.0A)
 0.83A 5x6yA-4rl8A:
undetectable		 5x6yA-4rl8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		3 TYR A 456
ASP A 437
ASP A 488
 None
 0.83A 5x6yA-4ru4A:
undetectable		 5x6yA-4ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TYR A 311
ASP A 231
ASP A 335
 None
 0.76A 5x6yA-4rvwA:
undetectable		 5x6yA-4rvwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 3 TYR D   9
ASP D  32
ASP D   7
 None
 0.85A 5x6yA-4s1vD:
1.8		 5x6yA-4s1vD:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 TYR A 253
ASP A 250
ASP A 135
 None
 0.82A 5x6yA-4wd9A:
undetectable		 5x6yA-4wd9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 TYR A 233
ASP A 229
ASP A 231
 None
 0.64A 5x6yA-4y9lA:
undetectable		 5x6yA-4y9lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z48 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF17131
(LolA_like) 		3 TYR A  85
ASP A 113
ASP A  83
 None
 0.83A 5x6yA-4z48A:
undetectable		 5x6yA-4z48A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 3 TYR A1104
ASP A1115
ASP A 648
 None
 0.79A 5x6yA-5b2oA:
undetectable		 5x6yA-5b2oA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6f ANTI-LEUKOTRIENE C4
MONOCLONAL ANTIBODY
IMMUNOGLOBULIN
GAMMA1 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR B 115
ASP B  65
ASP B 111
 None
 0.85A 5x6yA-5b6fB:
undetectable		 5x6yA-5b6fB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 3 TYR E 299
ASP E 196
ASP E 322
 FAD  E 501 ( 4.3A)
None
None
 0.67A 5x6yA-5dbjE:
undetectable		 5x6yA-5dbjE:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TYR A 632
ASP A 629
ASP A 654
 None
 0.82A 5x6yA-5favA:
undetectable		 5x6yA-5favA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcd MCCD

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		3 TYR A 104
ASP A  80
ASP A  56
 None
 0.84A 5x6yA-5fcdA:
4.0		 5x6yA-5fcdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		3 TYR A 271
ASP A 255
ASP A 211
 None
 0.68A 5x6yA-5fifA:
2.3		 5x6yA-5fifA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 TYR A1119
ASP A1123
ASP A1090
 None
 0.81A 5x6yA-5fkuA:
undetectable		 5x6yA-5fkuA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5t ARGONAUTE

(Methanocaldococcus
jannaschii) 		PF02171
(Piwi) 		3 TYR A 150
ASP A 296
ASP A 148
 None
SO4  A1719 (-4.1A)
None
 0.56A 5x6yA-5g5tA:
1.9		 5x6yA-5g5tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 SEGREGATION AND
CONDENSATION PROTEIN
A

(Bacillus
subtilis) 		PF02616
(SMC_ScpA) 		3 TYR C 241
ASP C 203
ASP C 239
 None
 0.79A 5x6yA-5h67C:
undetectable		 5x6yA-5h67C:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		3 TYR A 449
ASP A 403
ASP A 451
 None
 0.58A 5x6yA-5ijbA:
undetectable		 5x6yA-5ijbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myk FAB C#17 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR B 107
ASP B 106
ASP B 100
 None
 0.81A 5x6yA-5mykB:
undetectable		 5x6yA-5mykB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 3 TYR A 327
ASP A 325
ASP A 322
 None
 0.62A 5x6yA-5nijA:
2.9		 5x6yA-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 3 TYR A 409
ASP A 407
ASP A 263
 None
None
NA  A 501 (-2.9A)
 0.80A 5x6yA-5oeeA:
3.4		 5x6yA-5oeeA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5onu OUTER MEMBRANE
PROTEIN OMPU

(Vibrio cholerae) 		no annotation 3 TYR A 215
ASP A 213
ASP A 236
 None
 0.86A 5x6yA-5onuA:
undetectable		 5x6yA-5onuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6u CATHEPSIN K

(Mus musculus) 		PF00112
(Peptidase_C1) 		3 TYR A 150
ASP A 136
ASP A 152
 None
 0.79A 5x6yA-5t6uA:
undetectable		 5x6yA-5t6uA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfq BETA-LACTAMASE

(Bacteroides
cellulosilyticus) 		PF13354
(Beta-lactamase2) 		3 TYR A 245
ASP A  32
ASP A 175
 None
 0.72A 5x6yA-5tfqA:
undetectable		 5x6yA-5tfqA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		3 TYR A 227
ASP A 233
ASP A 320
 None
ZN  A 603 (-3.4A)
None
 0.85A 5x6yA-5tj3A:
undetectable		 5x6yA-5tj3A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 TYR A 680
ASP A 675
ASP A 644
 None
 0.86A 5x6yA-5tusA:
undetectable		 5x6yA-5tusA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 3 TYR C 285
ASP C 308
ASP C 359
 None
 0.23A 5x6yA-5x6xC:
55.9		 5x6yA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		3 TYR A 249
ASP A  78
ASP A 213
 None
 0.70A 5x6yA-5x7sA:
undetectable		 5x6yA-5x7sA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq NEUROLIGIN-2

(Homo sapiens) 		PF00135
(COesterase) 		3 TYR A 479
ASP A 377
ASP A 546
 None
 0.79A 5x6yA-5xeqA:
undetectable		 5x6yA-5xeqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS

(Homo sapiens) 		no annotation 3 TYR C  88
ASP C  38
ASP C  84
 None
 0.85A 5x6yA-6bnlC:
undetectable		 5x6yA-6bnlC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 TYR A1663
ASP A1707
ASP A2043
 None
 0.73A 5x6yA-6bq1A:
2.8		 5x6yA-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 3 TYR A  71
ASP A  93
ASP A  69
 None
 0.64A 5x6yA-6d5iA:
undetectable		 5x6yA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehc OUTER MEMBRANE
PROTEIN U

(Vibrio cholerae) 		no annotation 3 TYR A 185
ASP A 183
ASP A 206
 None
 0.75A 5x6yA-6ehcA:
undetectable		 5x6yA-6ehcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 3 TYR A 345
ASP A 381
ASP A 596
 None
 0.80A 5x6yA-6fbtA:
undetectable		 5x6yA-6fbtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghc -

(-) 		no annotation 3 TYR A  46
ASP A  39
ASP A   5
 None
 0.84A 5x6yA-6ghcA:
undetectable		 5x6yA-6ghcA:
undetectable