SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_A_SAMA902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		5 GLY A 245
ALA A  63
GLU A 238
THR A 246
PHE A 123
 None
 1.08A 5x6yA-1d5yA:
0.0		 5x6yA-1d5yA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 GLY A  14
ALA A 229
HIS A 228
VAL A  28
PHE A  57
 None
 1.21A 5x6yA-1db3A:
2.4		 5x6yA-1db3A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxx DYSTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  81
GLY A 109
GLU A  14
THR A 107
PHE A  41
 None
 1.27A 5x6yA-1dxxA:
0.7		 5x6yA-1dxxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A
PROTEASE A INHIBITOR
3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00026
(Asp)
PF10466
(Inhibitor_I34) 		5 LEU A 298
GLY A  34
ALA B  23
THR A  33
PHE A 151
 None
 1.34A 5x6yA-1g0vA:
0.0		 5x6yA-1g0vA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum
bicolor;
Sorghum bicolor) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		5 GLY A  26
ALA B 306
PHE A  43
VAL A  29
PHE A 136
 None
 1.27A 5x6yA-1gxsA:
undetectable		 5x6yA-1gxsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqb APO-D-ALANYL CARRIER
PROTEIN

(Lactobacillus
casei) 		PF00550
(PP-binding) 		5 LEU A  11
ALA A  15
GLU A  33
PHE A  32
THR A  69
 None
 1.29A 5x6yA-1hqbA:
undetectable		 5x6yA-1hqbA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		5 LEU A 412
GLY A 300
PRO A 359
VAL A 115
PHE A  39
 None
 1.22A 5x6yA-1irxA:
undetectable		 5x6yA-1irxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6r METHIONINE SYNTHASE

(Thermotoga
maritima) 		no annotation 5 LEU A  47
GLY A  96
ALA A  50
THR A  94
VAL A  55
 None
 1.35A 5x6yA-1j6rA:
undetectable		 5x6yA-1j6rA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 GLY A 185
PRO A 193
ALA A 192
THR A  46
VAL A  42
 None
 1.35A 5x6yA-1kplA:
undetectable		 5x6yA-1kplA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aeropyrum
pernix) 		PF01791
(DeoC) 		5 GLY A 176
ALA A 211
LYS A 167
GLU A 142
VAL A 172
 None
 1.34A 5x6yA-1n7kA:
undetectable		 5x6yA-1n7kA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 5 LEU B   5
PRO B   7
ALA B   6
PRO B  10
THR B  28
 None
 1.12A 5x6yA-1pbyB:
undetectable		 5x6yA-1pbyB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		5 LEU A 188
PRO A 238
ALA A 237
GLU A 249
PHE A 247
 None
 1.09A 5x6yA-1pwwA:
undetectable		 5x6yA-1pwwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 344
GLY A 203
THR A 205
VAL A 208
PHE A 268
 ANP  A 901 (-4.6A)
ANP  A 901 (-3.0A)
ANP  A 901 (-3.2A)
None
None
 1.15A 5x6yA-1qvrA:
2.8		 5x6yA-1qvrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PRO A  54
ALA A  53
GLU A  63
PHE A  65
VAL A   6
 None
 1.20A 5x6yA-1rvkA:
undetectable		 5x6yA-1rvkA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 LEU A  22
GLY A  17
PRO A  20
THR A 291
VAL A 284
 None
 1.30A 5x6yA-1sh2A:
undetectable		 5x6yA-1sh2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		5 GLY A 106
HIS A  11
PRO A 111
THR A 104
PHE A 102
 None
ZN  A 302 ( 3.4A)
None
None
None
 1.21A 5x6yA-1su1A:
undetectable		 5x6yA-1su1A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ui1 URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		5 LEU A 159
GLY A  59
ALA A 157
PRO A  53
GLU A  29
 None
 1.22A 5x6yA-1ui1A:
undetectable		 5x6yA-1ui1A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		5 LEU A  10
GLY A  80
ALA A   9
VAL A  75
PHE A  51
 None
 1.22A 5x6yA-1wloA:
undetectable		 5x6yA-1wloA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 691
GLY A 491
PRO A 486
PRO A 517
VAL A 507
 None
 1.31A 5x6yA-1zcjA:
3.1		 5x6yA-1zcjA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		5 LEU A  77
GLY A  67
ALA A  72
VAL A  89
PHE A 121
 None
MG  A 401 ( 4.3A)
None
None
None
 1.32A 5x6yA-1zlpA:
undetectable		 5x6yA-1zlpA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		5 GLY H  64
PRO H  39
ALA H  40
HIS H 362
PHE H 101
 None
 1.23A 5x6yA-2bbkH:
undetectable		 5x6yA-2bbkH:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 GLY A  94
ALA A 167
HIS A 166
PRO A  84
THR A 116
 None
 1.27A 5x6yA-2bi3A:
1.2		 5x6yA-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 LEU A 138
GLY A  94
ALA A 167
HIS A 166
PRO A  84
 None
 1.19A 5x6yA-2bi3A:
1.2		 5x6yA-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		5 GLY A 103
ALA A 133
THR A 106
VAL A 109
PHE A  68
 CO  A 603 (-3.1A)
None
CO  A 603 (-4.0A)
None
None
 1.00A 5x6yA-2d2xA:
2.0		 5x6yA-2d2xA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 LEU A 179
PRO A 275
ALA A 184
GLU A 260
PHE A 252
 None
 1.05A 5x6yA-2dulA:
6.3		 5x6yA-2dulA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE

(Archaeoglobus
fulgidus) 		PF01884
(PcrB) 		5 GLY A1123
PRO A1162
PHE A1159
THR A1082
VAL A1080
 None
None
None
None
MPD  A4001 (-4.5A)
 1.07A 5x6yA-2f6xA:
undetectable		 5x6yA-2f6xA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0s RNA-BINDING PROTEIN
8A

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU D 104
GLY D  79
ALA D  84
PRO D 143
THR D  78
 None
 1.34A 5x6yA-2j0sD:
undetectable		 5x6yA-2j0sD:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8w DESIGNED PROTEIN
DA05R1

(synthetic
construct) 		no annotation 5 LEU A  71
GLY A  32
ALA A  74
GLU A   9
PHE A   8
 None
 1.32A 5x6yA-2n8wA:
2.4		 5x6yA-2n8wA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		5 GLY A  34
ALA A  31
GLU A 231
PHE A  36
PHE A   8
 None
 1.26A 5x6yA-2opjA:
undetectable		 5x6yA-2opjA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		5 GLY A  30
PRO A  33
LYS A  57
GLU A  71
VAL A 116
 SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.2A)
SAM  A 203 (-4.9A)
None
 0.69A 5x6yA-2plwA:
8.7		 5x6yA-2plwA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 231
GLY A 278
ALA A 223
GLU A 304
VAL A 319
 None
SO4  A2009 ( 4.0A)
None
None
None
 1.22A 5x6yA-2q27A:
2.8		 5x6yA-2q27A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		5 LEU A 257
GLY A 139
PRO A 136
PRO A 290
PHE A 312
 None
 1.31A 5x6yA-2tbvA:
undetectable		 5x6yA-2tbvA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 GLY A 244
PRO A 239
ALA A 238
PHE A 291
THR A 286
 None
 1.30A 5x6yA-2w9mA:
undetectable		 5x6yA-2w9mA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		5 GLY A 223
ALA A 201
HIS A 199
PRO A 214
THR A 224
 None
 1.22A 5x6yA-2yzwA:
undetectable		 5x6yA-2yzwA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 337
PRO A 340
ALA A 129
GLU A 155
VAL A 134
 None
 1.23A 5x6yA-2zc8A:
undetectable		 5x6yA-2zc8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 LEU A  94
ALA A  90
PHE A 147
VAL A 268
PHE A 188
 None
WO4  A 400 (-3.5A)
None
None
None
 1.32A 5x6yA-3cijA:
2.5		 5x6yA-3cijA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		5 GLY A 148
ALA A 144
THR A 109
VAL A  61
PHE A 246
 None
 1.34A 5x6yA-3e59A:
undetectable		 5x6yA-3e59A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		5 GLY A 196
PRO A 192
ALA A 226
VAL A 166
PHE A 207
 None
 1.25A 5x6yA-3en0A:
undetectable		 5x6yA-3en0A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ex7 RNA-BINDING PROTEIN
8A

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU B 104
GLY B  79
ALA B  84
PRO B 143
THR B  78
 None
 1.33A 5x6yA-3ex7B:
undetectable		 5x6yA-3ex7B:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		5 LEU A1320
GLY A1257
ALA A1110
PHE A1262
THR A1249
 None
 1.33A 5x6yA-3fq8A:
undetectable		 5x6yA-3fq8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		5 GLY A 209
ALA A 102
PRO A 243
THR A 207
PHE A 226
 None
 1.27A 5x6yA-3grhA:
undetectable		 5x6yA-3grhA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		5 GLY A 377
PRO A 355
ALA A 353
HIS A 348
THR A 270
 None
 1.23A 5x6yA-3hmuA:
undetectable		 5x6yA-3hmuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Bacteroides
thetaiotaomicron) 		PF01012
(ETF) 		5 LEU A 115
GLY A  95
ALA A 165
GLU A 169
THR A  97
 None
 1.26A 5x6yA-3ih5A:
2.2		 5x6yA-3ih5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwr CHITINASE

(Oryza sativa) 		PF00182
(Glyco_hydro_19) 		5 GLY A 279
PRO A 276
ALA A 275
THR A 282
VAL A 285
 None
MPD  A 341 (-4.8A)
None
None
MES  A   1 (-4.8A)
 1.21A 5x6yA-3iwrA:
undetectable		 5x6yA-3iwrA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 LEU A 253
GLY A 105
ALA A 123
GLU A  62
PHE A 145
 None
 1.28A 5x6yA-3krzA:
undetectable		 5x6yA-3krzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 LEU X 216
GLY X 144
ALA X 164
THR X 143
VAL X  10
 None
 1.19A 5x6yA-3kvnX:
undetectable		 5x6yA-3kvnX:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF) 		5 LEU C 188
PRO C 238
ALA C 237
GLU C 249
PHE C 247
 None
 1.34A 5x6yA-3kwvC:
undetectable		 5x6yA-3kwvC:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 242
ALA A 354
PRO A  14
PHE A  62
VAL A 201
 None
 1.20A 5x6yA-3kzuA:
undetectable		 5x6yA-3kzuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		5 LEU A  30
GLY A 134
PRO A  93
PRO A 140
VAL A 181
 None
 1.28A 5x6yA-3l3bA:
undetectable		 5x6yA-3l3bA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		5 LEU A  20
GLY A  15
PRO A  29
HIS A  27
GLU A 404
 None
None
None
SO4  A 450 (-4.1A)
None
 1.28A 5x6yA-3mznA:
undetectable		 5x6yA-3mznA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw9 UPF0603 PROTEIN
AT1G54780,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04536
(TPM_phosphatase) 		5 GLY A 166
PRO A 183
ALA A 184
PHE A 132
VAL A 151
 None
 1.23A 5x6yA-3pw9A:
undetectable		 5x6yA-3pw9A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 LEU A 118
GLY A  58
ALA A 111
PRO A  24
THR A  20
 None
 1.34A 5x6yA-3rrvA:
undetectable		 5x6yA-3rrvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 LEU A 274
GLY A 338
PHE A 393
THR A 341
VAL A 344
 GST  A 511 (-4.6A)
None
None
None
None
 1.29A 5x6yA-3v1vA:
undetectable		 5x6yA-3v1vA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 246
GLY A 238
ALA A 244
PHE A 236
VAL A 103
 None
 1.33A 5x6yA-3viuA:
undetectable		 5x6yA-3viuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 LEU A 259
GLY A 265
PRO A 262
ALA A 261
PHE A 491
 None
 1.28A 5x6yA-3x0vA:
undetectable		 5x6yA-3x0vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zv8 3C PROTEASE

(Enterovirus D) 		PF00548
(Peptidase_C3) 		5 LEU A 174
GLY A 148
ALA A 172
THR A  26
VAL A  17
 None
 1.27A 5x6yA-3zv8A:
undetectable		 5x6yA-3zv8A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE

(Sphingomonas
elodea) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 365
GLY A 321
ALA A 361
PRO A 326
GLU A 389
 None
 1.28A 5x6yA-4a7pA:
2.0		 5x6yA-4a7pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP

(Acidothermus
cellulolyticus) 		PF03136
(Pup_ligase) 		5 ALA A 309
PRO A 282
GLU A 212
PHE A 209
VAL A 170
 None
 1.25A 5x6yA-4b0sA:
undetectable		 5x6yA-4b0sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnq NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01725
(Ham1p_like) 		5 LEU A 105
GLY A  78
ALA A  75
VAL A 116
PHE A  45
 None
 1.19A 5x6yA-4bnqA:
undetectable		 5x6yA-4bnqA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 LEU A 161
PRO A 184
ALA A 183
GLU A  24
PHE A 224
 None
 1.15A 5x6yA-4bo6A:
3.4		 5x6yA-4bo6A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 LEU A 352
GLY B 327
ALA A 323
GLU B 476
PHE A 669
 None
 1.07A 5x6yA-4cakA:
undetectable		 5x6yA-4cakA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 GLY I 226
HIS I 365
GLU I 283
THR I 230
PHE I 280
 None
 1.21A 5x6yA-4cr2I:
undetectable		 5x6yA-4cr2I:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		5 LEU A  93
GLY A  73
PRO A 197
THR A  71
VAL A  69
 None
 1.29A 5x6yA-4e4jA:
undetectable		 5x6yA-4e4jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		5 LEU A 344
GLY A 203
THR A 205
VAL A 208
PHE A 268
 ADP  A 602 (-4.6A)
ADP  A 602 (-3.4A)
ADP  A 602 (-4.0A)
None
None
 1.15A 5x6yA-4hseA:
undetectable		 5x6yA-4hseA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip3 ORF169B

(Shigella
flexneri) 		no annotation 5 LEU A 127
GLY A 149
ALA A 123
VAL A 192
PHE A 197
 None
 1.25A 5x6yA-4ip3A:
undetectable		 5x6yA-4ip3A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		5 LEU A  26
ALA A 322
GLU A 247
THR A 397
VAL A 395
 None
None
None
FMT  A 504 (-3.0A)
FMT  A 504 (-3.8A)
 1.20A 5x6yA-4j6cA:
undetectable		 5x6yA-4j6cA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		PF02128
(Peptidase_M36)
PF07504
(FTP) 		5 LEU A 562
GLY A 597
HIS A 541
THR A 592
PHE B 127
 None
None
None
None
GOL  B 305 (-4.2A)
 1.33A 5x6yA-4k90A:
undetectable		 5x6yA-4k90A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  24
ALA A  78
GLU A 363
THR A  85
VAL A  89
 None
 1.16A 5x6yA-4m9aA:
undetectable		 5x6yA-4m9aA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 GLY B 149
ALA B  72
PHE B 198
THR B 174
VAL B 202
 None
 1.30A 5x6yA-4nfuB:
undetectable		 5x6yA-4nfuB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 LEU A 145
GLY A 247
PRO A 527
ALA A 260
GLU A 538
 None
 1.22A 5x6yA-4nurA:
undetectable		 5x6yA-4nurA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8c THERMOSTABLE NPPASE

(Geobacillus
stearothermophilus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A 151
GLY A 119
PHE A  91
THR A 145
VAL A 179
 None
 1.20A 5x6yA-4o8cA:
undetectable		 5x6yA-4o8cA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 188
PRO A 215
HIS A 312
THR A 116
VAL A 114
 None
 1.33A 5x6yA-4q05A:
undetectable		 5x6yA-4q05A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 249
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.24A 5x6yA-4tmcA:
undetectable		 5x6yA-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 293
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.27A 5x6yA-4tmcA:
undetectable		 5x6yA-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 349
ALA A 311
PRO A 283
GLU A 284
THR A 332
 None
None
NAG  A2004 (-4.3A)
None
None
 1.21A 5x6yA-4xwhA:
undetectable		 5x6yA-4xwhA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis) 		PF04255
(DUF433) 		5 LEU A  18
GLY A  72
ALA A  21
PHE A  11
THR A  56
 None
 1.31A 5x6yA-5af3A:
undetectable		 5x6yA-5af3A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H   8
PRO H 202
GLU H  10
THR H 107
VAL H 109
 None
 1.13A 5x6yA-5alcH:
undetectable		 5x6yA-5alcH:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cu1 DMSP LYASE

(Ruegeria
pomeroyi) 		PF16867
(DMSP_lyase) 		5 LEU A  80
PRO A  46
PHE A  69
VAL A  75
PHE A   8
 None
 1.34A 5x6yA-5cu1A:
undetectable		 5x6yA-5cu1A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A 149
PRO A 147
ALA A 148
GLU A 182
THR A 186
 None
 1.09A 5x6yA-5ebbA:
undetectable		 5x6yA-5ebbA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		5 LEU A 194
GLY A 220
ALA A 191
GLU A 243
THR A 237
 None
 1.09A 5x6yA-5h0iA:
2.6		 5x6yA-5h0iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 386
GLY A 106
PRO A  99
PHE A 104
THR A 109
 None
 1.34A 5x6yA-5h7kA:
undetectable		 5x6yA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgq LYSINE--TRNA LIGASE

(Loa loa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 128
GLY A 118
ALA A 121
GLU A 134
PHE A  31
 None
 1.33A 5x6yA-5hgqA:
undetectable		 5x6yA-5hgqA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		5 HIS A  13
PHE A 345
THR A  95
VAL A   7
PHE A  97
 None
 1.20A 5x6yA-5hxzA:
undetectable		 5x6yA-5hxzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 199
ALA A 334
HIS A 333
THR A 123
VAL A 155
 None
 1.14A 5x6yA-5iq0A:
undetectable		 5x6yA-5iq0A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		5 LEU 1 128
GLY 1 305
ALA 1 131
THR 1 307
PHE 1 219
 None
 1.34A 5x6yA-5mz61:
undetectable		 5x6yA-5mz61:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S9

(Mycolicibacterium
smegmatis) 		PF00380
(Ribosomal_S9) 		5 LEU I  67
GLY I 122
PRO I  71
ALA I  70
THR I 125
 None
None
None
None
A  A1161 ( 2.6A)
 1.32A 5x6yA-5o5jI:
undetectable		 5x6yA-5o5jI:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 5 PRO A  35
ALA A  29
GLU A 121
VAL A  72
PHE A  70
 None
 1.26A 5x6yA-5ok4A:
undetectable		 5x6yA-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 5 LEU A  84
GLY A  61
PRO A  70
GLU A  65
PHE A  63
 None
 1.03A 5x6yA-5oshA:
undetectable		 5x6yA-5oshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv9 BOR1P BORON
TRANSPORTER

(Saccharomyces
mikatae) 		PF00955
(HCO3_cotransp) 		5 GLY A 354
PRO A 357
ALA A 359
HIS A 362
PHE A 306
 None
 1.12A 5x6yA-5sv9A:
undetectable		 5x6yA-5sv9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 GLY A  11
ALA A 290
PRO A  17
VAL A  39
PHE A 123
 FAD  A 405 (-3.3A)
None
None
None
None
 1.23A 5x6yA-5tufA:
undetectable		 5x6yA-5tufA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 5 LEU A 363
GLY A 290
PRO A 214
GLU A 216
THR A 336
 None
 1.14A 5x6yA-5w7qA:
undetectable		 5x6yA-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 LEU A  87
GLY A 972
ALA A  85
VAL A 573
PHE A 569
 None
 1.19A 5x6yA-5wblA:
2.2		 5x6yA-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 11 LEU C 269
GLY C 287
PRO C 290
ALA C 291
HIS C 293
LYS C 310
GLU C 333
PHE C 334
THR C 360
VAL C 362
PHE C 369
 None
 0.64A 5x6yA-5x6xC:
55.9		 5x6yA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 11 LEU C 269
GLY C 287
PRO C 290
ALA C 291
HIS C 293
PRO C 309
LYS C 310
GLU C 333
PHE C 334
THR C 360
PHE C 369
 None
 0.60A 5x6yA-5x6xC:
55.9		 5x6yA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 8 LEU C 269
GLY C 287
PRO C 290
ALA C 291
HIS C 293
PRO C 309
LYS C 310
PHE C 336
 None
 1.33A 5x6yA-5x6xC:
55.9		 5x6yA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9u THERMOSOME, ALPHA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		no annotation 5 LEU A  17
GLY A 103
ALA A  21
GLU A 421
PHE A 419
 None
 1.25A 5x6yA-5x9uA:
undetectable		 5x6yA-5x9uA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 LEU D 904
GLY D 880
ALA D 919
GLU D 837
THR D 881
 None
 1.28A 5x6yA-5xbkD:
undetectable		 5x6yA-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 PRO A  72
ALA A  73
PRO A 355
THR A  92
VAL A  79
 None
 1.31A 5x6yA-5xh9A:
undetectable		 5x6yA-5xh9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 GLY A 199
PRO A 220
ALA A 187
VAL A 215
PHE A 174
 None
 1.29A 5x6yA-5y0mA:
undetectable		 5x6yA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 5 LEU A 290
GLY A 255
ALA A 289
GLU A 198
THR A 253
 None
None
None
None
PLP  A 601 ( 4.1A)
 1.24A 5x6yA-6enzA:
undetectable		 5x6yA-6enzA:
undetectable