SIMILAR PATTERNS OF AMINO ACIDS FOR 5X6Y_A_SAMA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dts DETHIOBIOTIN
SYNTHETASE

(Escherichia
coli) 		PF13500
(AAA_26) 		5 GLY A  35
ASP A 110
ALA A 109
SER A  62
LEU A  64
 None
 0.85A 5x6yA-1dtsA:
3.0		 5x6yA-1dtsA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
 None
 1.22A 5x6yA-1e6vB:
undetectable		 5x6yA-1e6vB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A  15
GLY A  16
GLU A  39
LYS A  40
ALA A 119
 None
FAD  A 462 (-3.4A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.1A)
FAD  A 462 (-4.0A)
 0.67A 5x6yA-1ebdA:
undetectable		 5x6yA-1ebdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		5 VAL A 204
GLY A 205
SER A  22
ASP A  94
LEU A 200
 None
 1.24A 5x6yA-1ekqA:
undetectable		 5x6yA-1ekqA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 VAL A   7
GLY A   8
GLU A  31
LYS A  32
ASP A 212
 FAD  A 450 (-4.7A)
FAD  A 450 (-3.2A)
FAD  A 450 (-2.8A)
FAD  A 450 (-3.8A)
FAD  A 450 (-3.5A)
 0.79A 5x6yA-1i8tA:
undetectable		 5x6yA-1i8tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		5 GLY A1792
GLU A1672
LEU A1796
ASN A1795
ASN A1731
 None
 1.15A 5x6yA-1iahA:
undetectable		 5x6yA-1iahA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		5 VAL A1790
GLY A1792
LEU A1796
ASN A1795
ASN A1731
 None
 1.15A 5x6yA-1iahA:
undetectable		 5x6yA-1iahA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		5 VAL A  98
GLY A  99
GLU A 121
ASP A 148
LEU A 221
 None
ADN  A 500 (-3.2A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.2A)
 1.13A 5x6yA-1jg3A:
5.1		 5x6yA-1jg3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLU A 407
SER A 409
ASP A 426
ALA A 427
ASN A 312
 FAD  A 701 (-2.9A)
FAD  A 701 ( 3.9A)
FAD  A 701 (-3.8A)
FAD  A 701 (-3.5A)
FAD  A 701 (-4.0A)
 0.96A 5x6yA-1jscA:
2.6		 5x6yA-1jscA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		5 VAL A  96
ALA A  13
SER A 107
LEU A  80
ASN A  77
 None
 0.97A 5x6yA-1p8rA:
3.5		 5x6yA-1p8rA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		5 GLY E 181
ALA E 166
SER E 193
ASN E 161
ASN E 162
 None
 1.24A 5x6yA-1pekE:
undetectable		 5x6yA-1pekE:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		5 VAL A 206
GLY A 207
GLU A 238
SER A 235
ASN A 106
 None
None
None
None
BMD  A1001 ( 4.0A)
 1.02A 5x6yA-1qnlA:
2.2		 5x6yA-1qnlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 356
GLY A 355
ASP A 352
SER A 274
LEU A 275
 None
 0.96A 5x6yA-1skxA:
undetectable		 5x6yA-1skxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		6 VAL A 242
GLY A 241
ASP A 216
ALA A 214
SER A 288
LEU A 291
 PLP  A 962 (-4.8A)
PLP  A 962 (-4.3A)
None
None
PLP  A 962 (-4.2A)
None
 1.18A 5x6yA-1tdjA:
2.5		 5x6yA-1tdjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		5 ALA A 363
SER A 341
LEU A 342
ASN A 345
ASN A 361
 None
 1.21A 5x6yA-1uusA:
undetectable		 5x6yA-1uusA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		5 VAL A1879
GLY A1880
ASP A1938
ALA A1935
LEU A1870
 None
 0.96A 5x6yA-1uyvA:
3.2		 5x6yA-1uyvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2) 		6 VAL A   6
GLY A   7
LYS A  30
ALA A  75
LEU A 230
ASN A 227
 None
FAD  A 360 (-3.2A)
FAD  A 360 (-4.7A)
FAD  A 360 (-3.6A)
FAD  A 360 ( 4.3A)
None
 1.04A 5x6yA-1xhcA:
2.9		 5x6yA-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL B 275
GLY B 274
ASP B 271
SER B 192
LEU B 193
 None
 0.99A 5x6yA-1xv9B:
undetectable		 5x6yA-1xv9B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6z HEAT SHOCK PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00183
(HSP90) 		5 VAL A 160
ALA A 171
SER A 243
LEU A 244
ASN A 247
 None
 1.15A 5x6yA-1y6zA:
undetectable		 5x6yA-1y6zA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		5 VAL A 127
GLY A 135
ASP A 238
ALA A 239
LEU A 129
 None
 1.11A 5x6yA-1zc6A:
undetectable		 5x6yA-1zc6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 VAL A 203
GLY A 202
ALA A 194
SER A 243
LEU A 247
 None
 1.11A 5x6yA-2bi3A:
undetectable		 5x6yA-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Bacillus
subtilis) 		PF02390
(Methyltransf_4) 		5 VAL A  45
GLY A  46
GLU A  69
ASP A  96
ALA A  97
 None
K  A 250 (-3.9A)
None
None
None
 1.10A 5x6yA-2fcaA:
5.3		 5x6yA-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		5 VAL A  41
GLY A  42
GLU A  71
ALA A 167
LEU A 219
 FAD  A 611 (-4.9A)
FAD  A 611 (-3.3A)
FAD  A 611 (-2.9A)
FAD  A 611 (-3.3A)
FAD  A 611 (-4.4A)
 0.73A 5x6yA-2gmhA:
undetectable		 5x6yA-2gmhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		5 VAL A 144
GLY A 145
ALA A 132
LEU A 193
ASN A 196
 None
 0.99A 5x6yA-2hs5A:
undetectable		 5x6yA-2hs5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.93A 5x6yA-2pt6A:
4.5		 5x6yA-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7t PROTEIN TRAI

(Escherichia
coli) 		PF08751
(TrwC) 		5 GLY A 184
GLU A 187
SER A 176
LEU A 175
ASN A 164
 None
 1.09A 5x6yA-2q7tA:
undetectable		 5x6yA-2q7tA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 VAL A 779
GLY A 780
SER A 776
LEU A 775
ASN A 815
 None
 1.13A 5x6yA-2zxqA:
undetectable		 5x6yA-2zxqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes) 		PF08241
(Methyltransf_11) 		5 VAL A  68
GLY A  69
ASP A 119
ALA A 120
SER A 138
 None
SAH  A 274 (-3.1A)
SAH  A 274 (-3.6A)
SAH  A 274 (-3.5A)
None
 0.87A 5x6yA-3busA:
5.9		 5x6yA-3busA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		5 VAL A 105
SER A   2
ASP A 100
ALA A  97
LEU A   7
 None
 1.00A 5x6yA-3cgxA:
1.9		 5x6yA-3cgxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 GLY A 212
GLU A 240
ASP A 293
ALA A 294
SER A 216
 None
 1.22A 5x6yA-3ed4A:
undetectable		 5x6yA-3ed4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE

(Clostridioides
difficile) 		PF02861
(Clp_N) 		5 VAL A  28
GLY A  29
GLU A  31
ALA A  16
SER A  83
 None
 1.16A 5x6yA-3fesA:
undetectable		 5x6yA-3fesA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		7 VAL A  53
GLY A  54
GLU A  75
LYS A  76
ASP A  99
ALA A 100
LEU A 126
 None
 0.96A 5x6yA-3futA:
8.1		 5x6yA-3futA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 VAL A  53
GLY A  54
GLU A  75
LYS A  76
LEU A 118
 None
 1.04A 5x6yA-3futA:
8.1		 5x6yA-3futA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL

(Escherichia
coli) 		PF02254
(TrkA_N) 		5 VAL A 423
GLY A 424
GLU A 447
ALA A 468
LEU A 487
 AMP  A 601 ( 4.9A)
AMP  A 601 (-3.5A)
AMP  A 601 (-2.8A)
AMP  A 601 (-3.9A)
None
 1.06A 5x6yA-3fwzA:
4.8		 5x6yA-3fwzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		5 VAL A 257
GLY A 256
ALA A 233
LEU A 261
ASN A 262
 None
 1.16A 5x6yA-3g85A:
3.1		 5x6yA-3g85A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 VAL A 331
GLY A 314
ALA A 340
LEU A 271
ASN A 311
 None
 1.21A 5x6yA-3i04A:
4.6		 5x6yA-3i04A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		5 GLY A 206
SER A 227
ASP A 203
ALA A 202
LEU A 140
 GNG  A 800 (-3.6A)
None
None
None
None
 1.24A 5x6yA-3iomA:
undetectable		 5x6yA-3iomA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 VAL A1171
GLY A1170
ASP A  14
ALA A  15
LEU A1161
 None
 1.14A 5x6yA-3jroA:
undetectable		 5x6yA-3jroA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrp FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 VAL A1171
GLY A1170
ASP A  14
ALA A  15
LEU A1161
 None
 1.23A 5x6yA-3jrpA:
undetectable		 5x6yA-3jrpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A  19
GLY A  20
GLU A  44
ALA A 232
LEU A 277
 None
FDA  A 547 (-3.2A)
FDA  A 547 (-2.7A)
FDA  A 547 (-3.6A)
None
 0.79A 5x6yA-3ljpA:
undetectable		 5x6yA-3ljpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE

(Oleispira
antarctica) 		PF00857
(Isochorismatase) 		5 VAL A 118
GLY A 119
ASP A 145
ALA A 143
LEU A  42
 None
 1.03A 5x6yA-3lqyA:
undetectable		 5x6yA-3lqyA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 142
GLY A 143
GLU A 308
ALA A 310
LEU A 312
 None
 1.20A 5x6yA-3moiA:
2.3		 5x6yA-3moiA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		5 GLY A 192
ASP A   8
ALA A  41
SER A 190
ASN A 217
 None
CA  A 267 ( 2.6A)
None
None
EPE  A 268 (-3.1A)
 1.19A 5x6yA-3pgvA:
3.5		 5x6yA-3pgvA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		5 VAL A1264
ASP A1184
LEU A1268
ASN A1270
ASN A1271
 None
 1.04A 5x6yA-3swhA:
undetectable		 5x6yA-3swhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 GLY A  40
GLU A  61
ASP A  86
ALA A  87
LEU A 115
 None
 0.91A 5x6yA-3tqsA:
4.3		 5x6yA-3tqsA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		5 GLY A  46
GLU A  71
ASP A  94
ALA A  95
LEU A 126
 None
 1.07A 5x6yA-3uzuA:
4.4		 5x6yA-3uzuA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 VAL A 454
GLY A 449
ASP A 276
ALA A 277
LEU A 357
 None
 1.19A 5x6yA-3wbhA:
2.3		 5x6yA-3wbhA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 163
GLY A 164
GLU A 305
ASP A 309
ALA A 308
 None
 1.13A 5x6yA-3wjpA:
undetectable		 5x6yA-3wjpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 VAL A 345
GLY A 347
ALA A 319
LEU A 256
ASN A 260
 None
 1.20A 5x6yA-3x0yA:
undetectable		 5x6yA-3x0yA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c98 CAS6B

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		5 VAL A 250
GLY A 251
ALA A 245
SER A 167
LEU A 168
 None
 1.22A 5x6yA-4c98A:
undetectable		 5x6yA-4c98A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		5 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
 None
 1.01A 5x6yA-4e2iA:
3.1		 5x6yA-4e2iA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 337
GLU A 343
ALA A 346
SER A 246
LEU A 245
 None
 1.23A 5x6yA-4eclA:
undetectable		 5x6yA-4eclA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacteroides
abscessus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 110
ALA A 238
SER A 263
ASN A  23
ASN A 232
 None
 1.24A 5x6yA-4emdA:
undetectable		 5x6yA-4emdA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A   7
GLY A   8
GLU A  33
LYS A  34
ASN A 242
 FAD  A 501 (-4.8A)
FAD  A 501 (-3.1A)
FAD  A 501 (-2.7A)
FAD  A 501 (-2.7A)
FAD  A 501 (-4.2A)
 1.21A 5x6yA-4emwA:
undetectable		 5x6yA-4emwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		5 VAL A 101
GLY A 100
ASP A  43
ALA A  44
LEU A  36
 None
None
IOD  A 301 ( 4.6A)
None
None
 1.02A 5x6yA-4fd7A:
undetectable		 5x6yA-4fd7A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A  25
GLY A 445
ASP A 454
ALA A 450
SER A  23
 None
 1.17A 5x6yA-4fxsA:
undetectable		 5x6yA-4fxsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C) 		5 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
 None
 0.95A 5x6yA-4gdfA:
2.7		 5x6yA-4gdfA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 GLY A 357
LYS A 349
ASP A 345
SER A 438
LEU A 439
 None
 0.99A 5x6yA-4gl2A:
2.1		 5x6yA-4gl2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 GLY A 358
ASP A 397
ALA A 398
LEU A 428
ASN A 425
 AMP  A 602 (-3.6A)
AMP  A 602 (-3.1A)
AMP  A 602 (-3.7A)
None
None
 1.17A 5x6yA-4gvlA:
undetectable		 5x6yA-4gvlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Archaeoglobus
fulgidus) 		PF02289
(MCH) 		5 VAL A 235
GLY A 207
GLU A  80
ALA A 188
LEU A 237
 None
 1.06A 5x6yA-4gvrA:
undetectable		 5x6yA-4gvrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikh GLUTATHIONE
S-TRANSFERASE

(Pseudomonas
protegens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 133
GLY A 134
ALA A 199
LEU A 193
ASN A 192
 None
 1.14A 5x6yA-4ikhA:
undetectable		 5x6yA-4ikhA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 VAL A 238
GLY A 239
GLU A 261
ASP A 283
ALA A 284
 None
AGS  A 502 (-3.3A)
AGS  A 502 (-2.4A)
AGS  A 502 (-2.9A)
AGS  A 502 (-3.2A)
 0.79A 5x6yA-4j9vA:
3.4		 5x6yA-4j9vA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 167
GLU A 165
SER A 162
ALA A 184
LEU A 229
 None
 1.08A 5x6yA-4jbhA:
3.3		 5x6yA-4jbhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		5 GLY A 185
LYS A 215
SER A 218
SER A 181
ASN A 179
 None
 1.24A 5x6yA-4l7mA:
undetectable		 5x6yA-4l7mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqx TENA/THI-4
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4)
PF16293
(zf-C2H2_9) 		6 VAL A  96
GLY A  95
GLU A 294
SER A 296
ALA A  88
LEU A 287
 None
None
None
CL  A 406 (-3.1A)
None
None
 1.46A 5x6yA-4lqxA:
undetectable		 5x6yA-4lqxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 GLY A  38
GLU A  39
SER A 236
ALA A 369
ASN A 177
 None
 1.21A 5x6yA-4my5A:
undetectable		 5x6yA-4my5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Pseudomonas
putida) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 133
GLY A 134
ALA A 198
LEU A 192
ASN A 191
 None
 1.17A 5x6yA-4naxA:
undetectable		 5x6yA-4naxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o29 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrobaculum
aerophilum) 		PF01135
(PCMT) 		5 VAL A  79
GLY A  80
GLU A 104
ASP A 132
LEU A 204
 None
SAH  A 500 (-3.1A)
SAH  A 500 (-2.8A)
SAH  A 500 (-4.0A)
SAH  A 500 (-4.3A)
 1.08A 5x6yA-4o29A:
5.8		 5x6yA-4o29A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 VAL A  37
SER A  41
ASP A  66
ALA A  65
LEU A  77
 None
 1.09A 5x6yA-4o3sA:
undetectable		 5x6yA-4o3sA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		5 VAL A  79
GLY A  80
ASP A 130
ALA A 131
SER A 149
 None
SAH  A 301 (-2.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.7A)
 0.87A 5x6yA-4pneA:
3.4		 5x6yA-4pneA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		5 VAL A 338
GLY A 335
SER A 329
ALA A 216
ASN A 203
 None
 1.24A 5x6yA-4qfhA:
2.8		 5x6yA-4qfhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
MTA  A 401 (-4.4A)
 0.87A 5x6yA-4uoeA:
4.1		 5x6yA-4uoeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 VAL A 218
GLY A 219
ALA A  40
LEU A 223
ASN A 267
 None
 0.91A 5x6yA-4uwqA:
undetectable		 5x6yA-4uwqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 VAL A 332
ASP A 252
LEU A 336
ASN A 338
ASN A 339
 None
 1.02A 5x6yA-4y21A:
undetectable		 5x6yA-4y21A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zal UBIX

(Pseudomonas
aeruginosa) 		PF02441
(Flavoprotein) 		5 GLY A 114
SER A 109
ALA A 124
ASN A 117
ASN A 118
 None
 1.10A 5x6yA-4zalA:
3.8		 5x6yA-4zalA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 VAL A 225
SER A 521
ALA A 236
LEU A 141
ASN A 138
 None
 1.22A 5x6yA-5a5gA:
undetectable		 5x6yA-5a5gA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 VAL B 347
GLY B 346
GLU B 339
ALA B 352
LEU B 310
 None
 1.14A 5x6yA-5a8rB:
undetectable		 5x6yA-5a8rB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 5 VAL A 276
GLY A 250
ALA A 103
SER A 279
LEU A 280
 None
 1.17A 5x6yA-5czcA:
undetectable		 5x6yA-5czcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 5 GLY E  12
GLU E  35
LYS E  36
LEU E 185
ASN E 183
 FAD  E 501 (-3.1A)
FAD  E 501 (-2.4A)
FAD  E 501 (-3.4A)
FAD  E 501 ( 4.1A)
FAD  E 501 (-3.8A)
 1.23A 5x6yA-5dbjE:
undetectable		 5x6yA-5dbjE:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 VAL A  12
GLU A  36
SER A 204
LEU A 203
ASN A 209
 FAD  A 401 (-4.7A)
FAD  A 401 (-2.8A)
None
None
None
 1.21A 5x6yA-5ez7A:
undetectable		 5x6yA-5ez7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 VAL A  12
GLY A  13
GLU A  36
SER A 204
LEU A 203
 FAD  A 401 (-4.7A)
FAD  A 401 (-3.3A)
FAD  A 401 (-2.8A)
None
None
 1.08A 5x6yA-5ez7A:
undetectable		 5x6yA-5ez7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 VAL A 422
GLY A 423
ASP A 352
ALA A 353
ASN A 419
 None
 1.06A 5x6yA-5fbzA:
undetectable		 5x6yA-5fbzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjy MHC CLASS I ANTIGEN
BETA-2-MICROGLOBULIN

(Anas
platyrhynchos;
Anas
platyrhynchos) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF07654
(C1-set) 		5 VAL A  31
GLY A  33
SER B  60
SER A   7
LEU A   8
 None
 1.17A 5x6yA-5gjyA:
undetectable		 5x6yA-5gjyA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 VAL A1920
GLY A1921
ASP A1979
ALA A1976
LEU A1911
 None
 0.93A 5x6yA-5i6gA:
2.4		 5x6yA-5i6gA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 VAL A1920
GLY A1921
ASP A1979
ALA A1976
LEU A1911
 None
 0.92A 5x6yA-5i6hA:
3.1		 5x6yA-5i6hA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 VAL A1920
GLY A1921
ASP A1979
ALA A1976
LEU A1911
 None
 0.95A 5x6yA-5i6iA:
2.7		 5x6yA-5i6iA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 VAL A 106
ALA A 145
SER A 109
LEU A 110
ASN A 113
 None
 1.17A 5x6yA-5lrbA:
undetectable		 5x6yA-5lrbA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		5 VAL A 353
GLY A 332
SER A 313
ASP A 341
ALA A 342
 None
 1.07A 5x6yA-5mvdA:
undetectable		 5x6yA-5mvdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
 None
 1.13A 5x6yA-5n28B:
undetectable		 5x6yA-5n28B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A 612
GLY A 613
SER A 682
ASP A 714
LEU A 608
 None
 1.05A 5x6yA-5v9xA:
3.1		 5x6yA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcu RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1 ISOFORM
X2

(Naegleria
fowleri) 		PF00071
(Ras) 		5 VAL A 113
GLY A 114
SER A 158
ALA A 168
LEU A  79
 None
None
GDP  A 301 (-3.5A)
None
None
 1.23A 5x6yA-5vcuA:
2.5		 5x6yA-5vcuA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A   6
GLY A   7
GLU A  32
LEU A 248
ASN A 245
 None
FAD  A 501 (-3.1A)
FAD  A 501 (-2.4A)
FAD  A 501 (-4.7A)
FAD  A 501 (-2.8A)
 1.11A 5x6yA-5vohA:
2.4		 5x6yA-5vohA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		5 VAL A 114
GLY A 115
SER A 146
ALA A 156
LEU A  79
 None
None
GNP  A 203 (-3.5A)
None
None
 1.23A 5x6yA-5wdrA:
2.0		 5x6yA-5wdrA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6v RAGULATOR COMPLEX
PROTEIN LAMTOR2
RAS-RELATED
GTP-BINDING PROTEIN
C

(Homo sapiens;
Mus musculus) 		no annotation
no annotation 		5 GLY G 349
ALA B  46
SER B  30
LEU B  31
ASN B  26
 None
 0.98A 5x6yA-5x6vG:
undetectable		 5x6yA-5x6vG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 SER C 232
ASP C 471
ALA C 472
SER C 488
ASN C 494
 None
 0.81A 5x6yA-5x6xC:
55.9		 5x6yA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 9 VAL C 209
GLY C 210
GLU C 230
ASP C 471
ALA C 472
SER C 488
LEU C 489
ASN C 491
ASN C 494
 None
 1.10A 5x6yA-5x6xC:
55.9		 5x6yA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 8 VAL C 209
GLY C 210
LYS C 231
ALA C 472
SER C 488
LEU C 489
ASN C 491
ASN C 494
 None
 1.15A 5x6yA-5x6xC:
55.9		 5x6yA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US13

(Toxoplasma
gondii) 		PF00416
(Ribosomal_S13) 		5 VAL S 101
GLY S  37
SER S  43
ALA S  73
LEU S  18
 None
U  21565 ( 3.3A)
None
None
None
 1.17A 5x6yA-5xxuS:
undetectable		 5x6yA-5xxuS:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 5 VAL A 253
GLY A 252
ALA A 240
SER A 267
LEU A 268
 None
 1.05A 5x6yA-6b2yA:
undetectable		 5x6yA-6b2yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f76 -

(-) 		no annotation 5 VAL B 114
GLY B 115
SER B 145
ALA B 155
LEU B  79
 None
None
GNP  B 202 (-3.6A)
None
None
 1.23A 5x6yA-6f76B:
2.3		 5x6yA-6f76B:
undetectable