SIMILAR PATTERNS OF AMINO ACIDS FOR 5X5Q_E_D16E402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 ILE A 194
ASP A 256
GLY A 253
TYR A 206
 None
 0.93A 5x5qE-1ayeA:
0.0		 5x5qE-1ayeA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		4 ILE A  93
ASP A 184
GLY A 188
TYR A 224
 None
 0.77A 5x5qE-1bsfA:
31.2		 5x5qE-1bsfA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		6 PHE A  58
ILE A  86
ASP A 202
LEU A 205
GLY A 206
TYR A 242
 CB3  A 768 (-3.6A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 3.6A)
CB3  A 768 ( 4.4A)
UMP  A 767 (-3.7A)
CB3  A 768 ( 4.7A)
 0.63A 5x5qE-1ci7A:
41.1		 5x5qE-1ci7A:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 114
LEU A 150
GLY A 149
TYR A 153
 None
 0.87A 5x5qE-1d6hA:
undetectable		 5x5qE-1d6hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 PHE A  94
ILE A 152
LEU A 218
GLY A 155
 None
 0.97A 5x5qE-1dubA:
undetectable		 5x5qE-1dubA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 ILE A1060
ASP A1056
LEU A1292
GLY A1057
 None
 0.96A 5x5qE-1eg7A:
0.0		 5x5qE-1eg7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		4 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.84A 5x5qE-1htwA:
0.0		 5x5qE-1htwA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		6 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.44A 5x5qE-1hvyA:
44.7		 5x5qE-1hvyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 ILE A 137
LEU A  45
GLY A 114
TYR A  24
 None
 1.01A 5x5qE-1idjA:
0.0		 5x5qE-1idjA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 ASP C 513
LEU C 516
GLY C 517
TYR C 553
 UMP  C 611 (-4.9A)
None
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
 0.58A 5x5qE-1j3jC:
40.3		 5x5qE-1j3jC:
53.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 ILE C 403
ASP C 513
GLY C 517
TYR C 553
 None
UMP  C 611 (-4.9A)
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
 0.49A 5x5qE-1j3jC:
40.3		 5x5qE-1j3jC:
53.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 PHE A 238
ILE A 213
LEU A 231
GLY A 232
 None
 0.55A 5x5qE-1mqsA:
undetectable		 5x5qE-1mqsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 PHE A  33
ILE A 441
ASP A 430
GLY A 426
 None
 0.91A 5x5qE-1o99A:
undetectable		 5x5qE-1o99A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		4 ILE A  80
ASP A  99
LEU A  98
GLY A  97
 None
 0.98A 5x5qE-1qoxA:
undetectable		 5x5qE-1qoxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		4 ILE A 183
ASP A 239
LEU A 235
GLY A 234
 None
 0.99A 5x5qE-1schA:
undetectable		 5x5qE-1schA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 ASP A 179
LEU A 182
GLY A 183
TYR A 219
 None
 0.54A 5x5qE-1tisA:
30.7		 5x5qE-1tisA:
43.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 PHE A 188
ILE A 163
ASP A 385
GLY A 386
 None
 0.95A 5x5qE-1wuuA:
undetectable		 5x5qE-1wuuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trypanosoma
cruzi) 		PF00160
(Pro_isomerase) 		4 PHE A  55
ILE A  12
ASP A  16
GLY A  15
 None
 0.97A 5x5qE-1xq7A:
undetectable		 5x5qE-1xq7A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbh 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T)
PF02037
(SAP) 		4 PHE A 154
ASP A 297
LEU A 296
GLY A 295
 None
None
None
MG  A1001 ( 4.3A)
 1.00A 5x5qE-1zbhA:
undetectable		 5x5qE-1zbhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 PHE A 154
ASP A 297
LEU A 296
GLY A 295
 None
None
None
MG  A1001 ( 4.1A)
 1.01A 5x5qE-1zbuA:
undetectable		 5x5qE-1zbuA:
23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		6 PHE A  72
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 CB3  A2351 (-3.9A)
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 0.73A 5x5qE-2aazA:
undetectable		 5x5qE-2aazA:
61.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 PHE A1097
ASP A1090
LEU A1093
GLY A1091
 None
 0.96A 5x5qE-2b5mA:
undetectable		 5x5qE-2b5mA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PHE A 182
ILE A 158
GLY A 189
TYR A 452
 None
 0.91A 5x5qE-2bvgA:
undetectable		 5x5qE-2bvgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		4 PHE A 218
ILE A 174
LEU A 260
GLY A 269
 None
 0.96A 5x5qE-2c0hA:
undetectable		 5x5qE-2c0hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.91A 5x5qE-2exrA:
undetectable		 5x5qE-2exrA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 PHE A  42
ILE A 155
ASP A 152
GLY A  49
 None
 0.98A 5x5qE-2fuvA:
undetectable		 5x5qE-2fuvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goy ADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01507
(PAPS_reduct) 		4 PHE A 193
ILE A  45
LEU A  69
GLY A 161
 None
 0.95A 5x5qE-2goyA:
undetectable		 5x5qE-2goyA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 PHE A 288
ILE A 316
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 None
None
None
None
DU  A 611 (-3.5A)
DU  A 611 (-4.6A)
 0.73A 5x5qE-2h2qA:
40.1		 5x5qE-2h2qA:
42.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		4 PHE A   9
ILE A 219
LEU A 194
GLY A 193
 None
 0.93A 5x5qE-2hszA:
undetectable		 5x5qE-2hszA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 ILE A  80
ASP A  99
LEU A  98
GLY A  97
 None
 1.00A 5x5qE-2j7cA:
undetectable		 5x5qE-2j7cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4j PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00486
(Trans_reg_C) 		4 ILE A  23
LEU A 113
GLY A  58
TYR A 111
 None
 0.85A 5x5qE-2k4jA:
undetectable		 5x5qE-2k4jA:
14.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.63A 5x5qE-2oipA:
41.4		 5x5qE-2oipA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 PHE A 207
ILE A 206
ASP A 164
GLY A 163
 None
None
ZN  A 301 (-2.5A)
None
 0.94A 5x5qE-2p18A:
undetectable		 5x5qE-2p18A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 PHE A 119
ASP A 122
LEU A 125
GLY A 121
 None
 0.89A 5x5qE-2pqdA:
undetectable		 5x5qE-2pqdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 PHE A 116
ILE A 149
ASP A 131
GLY A 108
 None
None
NAD  A 400 (-2.8A)
None
 0.93A 5x5qE-2pv7A:
undetectable		 5x5qE-2pv7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis) 		PF01381
(HTH_3) 		4 ILE A 135
ASP A 176
LEU A 177
GLY A 174
 None
 0.96A 5x5qE-2qfcA:
undetectable		 5x5qE-2qfcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 PHE A 195
ILE A 265
LEU A 237
GLY A 234
 None
 0.55A 5x5qE-2qtyA:
undetectable		 5x5qE-2qtyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG

(Helicobacter
pylori) 		PF00004
(AAA) 		4 PHE A 232
ILE A 266
ASP A 269
GLY A 235
 None
 0.85A 5x5qE-2r62A:
undetectable		 5x5qE-2r62A:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		4 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.83A 5x5qE-2tddA:
33.7		 5x5qE-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		4 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.65A 5x5qE-2tddA:
33.7		 5x5qE-2tddA:
45.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 PHE A 436
ILE A 416
ASP A 375
GLY A 374
 None
 0.97A 5x5qE-2w20A:
undetectable		 5x5qE-2w20A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		4 PHE A 121
ILE A 101
ASP A 125
GLY A 124
 None
 0.99A 5x5qE-2wgbA:
undetectable		 5x5qE-2wgbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa0 APOPTOSIS REGULATOR
BAX
APOPTOSIS REGULATOR
BCL-2

(Homo sapiens;
Mus musculus) 		PF00452
(Bcl-2)
PF02180
(BH4)
no annotation 		4 PHE A 150
ILE A 147
ASP C  68
GLY C  67
 None
 1.01A 5x5qE-2xa0A:
undetectable		 5x5qE-2xa0A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 4 PHE A  33
ILE A 225
LEU A   8
GLY A   7
 None
 0.95A 5x5qE-2xecA:
undetectable		 5x5qE-2xecA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yet GH61 ISOZYME A

(Thermoascus
aurantiacus) 		PF03443
(Glyco_hydro_61) 		4 PHE A 112
LEU A 199
GLY A 222
TYR A  49
 None
 0.79A 5x5qE-2yetA:
undetectable		 5x5qE-2yetA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 PHE A 405
ASP A 350
LEU A 349
GLY A 348
 None
 0.96A 5x5qE-2yw2A:
undetectable		 5x5qE-2yw2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE O 187
ILE O 283
LEU O 127
GLY O 126
 None
 0.89A 5x5qE-2zf5O:
undetectable		 5x5qE-2zf5O:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 ILE A 603
ASP A  34
LEU A  31
GLY A  32
 None
 0.90A 5x5qE-2zuyA:
undetectable		 5x5qE-2zuyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ILE A  18
LEU A 154
GLY A 322
TYR A 152
 None
 0.74A 5x5qE-3a31A:
undetectable		 5x5qE-3a31A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 PHE A 527
ILE A 116
GLY A 532
TYR A 562
 None
 0.91A 5x5qE-3bc9A:
undetectable		 5x5qE-3bc9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ILE A 520
LEU A 546
GLY A 576
TYR A 525
 None
 0.97A 5x5qE-3bgaA:
undetectable		 5x5qE-3bgaA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		4 ILE A 121
ASP A 144
LEU A 143
GLY A 142
 None
 0.74A 5x5qE-3bo7A:
undetectable		 5x5qE-3bo7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 ILE A  18
ASP A  34
LEU A  33
GLY A  32
 None
 0.90A 5x5qE-3d0cA:
undetectable		 5x5qE-3d0cA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 191
ILE A 289
LEU A 129
GLY A 128
 None
 0.92A 5x5qE-3g25A:
undetectable		 5x5qE-3g25A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		4 PHE A  85
ILE A 173
LEU A 216
GLY A 257
 None
 0.79A 5x5qE-3h9pA:
undetectable		 5x5qE-3h9pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF00072
(Response_reg) 		4 PHE A  48
ILE A  56
ASP A  40
GLY A  41
 None
 0.96A 5x5qE-3hdgA:
undetectable		 5x5qE-3hdgA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 ILE A 235
LEU A 250
GLY A 227
TYR A 408
 None
 1.01A 5x5qE-3i44A:
undetectable		 5x5qE-3i44A:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		4 ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
 0.72A 5x5qE-3ix6A:
33.8		 5x5qE-3ix6A:
41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		4 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 None
 0.67A 5x5qE-3ix6A:
33.8		 5x5qE-3ix6A:
41.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		4 ILE A 198
ASP A 223
LEU A 164
GLY A 227
 None
 0.99A 5x5qE-3k11A:
undetectable		 5x5qE-3k11A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 PHE A  57
ILE A  14
ASP A  32
GLY A  31
 None
 0.98A 5x5qE-3k2kA:
undetectable		 5x5qE-3k2kA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k32 UNCHARACTERIZED
PROTEIN MJ0690

(Methanocaldococcus
jannaschii) 		no annotation 4 PHE A 138
ILE A  22
ASP A 104
GLY A 105
 None
 0.82A 5x5qE-3k32A:
undetectable		 5x5qE-3k32A:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		4 PHE A  60
LEU A 200
GLY A 201
TYR A 237
 None
 0.82A 5x5qE-3kgbA:
36.7		 5x5qE-3kgbA:
58.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		4 ILE A  97
ASP A  35
LEU A  42
GLY A  43
 None
 0.98A 5x5qE-3kjeA:
undetectable		 5x5qE-3kjeA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ASP A 416
LEU A 419
GLY A 420
TYR A 456
 None
 0.60A 5x5qE-3kjrA:
41.0		 5x5qE-3kjrA:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 PHE A 293
ILE A 302
LEU A 325
GLY A 326
 GOL  A 387 (-4.5A)
None
None
None
 0.92A 5x5qE-3lduA:
undetectable		 5x5qE-3lduA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 PHE A 720
LEU A 726
GLY A 725
TYR A 746
 None
 0.94A 5x5qE-3mkqA:
undetectable		 5x5qE-3mkqA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7t CYCLOPHILIN A

(Moniliophthora
perniciosa) 		PF00160
(Pro_isomerase) 		4 ILE A 112
ASP A 135
LEU A 134
GLY A 133
 None
 0.82A 5x5qE-3o7tA:
undetectable		 5x5qE-3o7tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		4 PHE A 172
ILE A 168
ASP A 179
GLY A 178
 None
 0.82A 5x5qE-3pshA:
undetectable		 5x5qE-3pshA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0h INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		4 PHE A 560
ILE A 517
ASP A 627
GLY A 626
 None
 0.99A 5x5qE-3r0hA:
undetectable		 5x5qE-3r0hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ASP A 513
LEU A 516
GLY A 517
TYR A 553
 UMP  A 611 (-4.9A)
None
UMP  A 611 (-3.3A)
UMP  A 611 (-4.5A)
 0.61A 5x5qE-3um6A:
40.4		 5x5qE-3um6A:
27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ILE A 403
ASP A 513
GLY A 517
TYR A 553
 None
UMP  A 611 (-4.9A)
UMP  A 611 (-3.3A)
UMP  A 611 (-4.5A)
 0.50A 5x5qE-3um6A:
40.4		 5x5qE-3um6A:
27.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		4 ASP A 217
LEU A 220
GLY A 221
TYR A 257
 None
None
None
CIT  A 400 (-4.5A)
 0.73A 5x5qE-3v8hA:
34.7		 5x5qE-3v8hA:
35.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 PHE A 118
ILE A  87
GLY A  58
TYR A  91
 None
None
None
NAG  A 920 (-3.7A)
 0.94A 5x5qE-3zk4A:
undetectable		 5x5qE-3zk4A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ILE A 447
LEU A 472
GLY A 470
TYR A 489
 None
 0.80A 5x5qE-4aeeA:
undetectable		 5x5qE-4aeeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 PHE A 272
ASP A 216
LEU A 228
GLY A 227
TYR A 122
 None
 1.43A 5x5qE-4ag4A:
undetectable		 5x5qE-4ag4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 PHE A  98
LEU A  15
GLY A  12
TYR A 179
 None
None
None
GSP  A1342 (-3.8A)
 0.89A 5x5qE-4b45A:
undetectable		 5x5qE-4b45A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PHE A 182
ILE A 160
ASP A 248
GLY A 163
 None
 1.00A 5x5qE-4bziA:
undetectable		 5x5qE-4bziA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		4 ASP A 224
LEU A 227
GLY A 228
TYR A 264
 None
None
UMP  A 501 ( 4.0A)
UMP  A 501 (-4.2A)
 0.71A 5x5qE-4dq1A:
34.1		 5x5qE-4dq1A:
45.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		4 ILE A  84
ASP A 224
GLY A 228
TYR A 264
 None
None
UMP  A 501 ( 4.0A)
UMP  A 501 (-4.2A)
 0.64A 5x5qE-4dq1A:
34.1		 5x5qE-4dq1A:
45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PHE A 161
ILE A 155
LEU A 165
GLY A 166
 None
 0.96A 5x5qE-4f32A:
undetectable		 5x5qE-4f32A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		4 PHE A  15
ILE A  34
ASP A  43
GLY A  44
 None
 0.84A 5x5qE-4fhaA:
undetectable		 5x5qE-4fhaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		4 PHE A 198
ILE A 227
ASP A 206
GLY A 207
 None
 0.98A 5x5qE-4fhaA:
undetectable		 5x5qE-4fhaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 PHE A 522
ILE A 560
LEU A 574
GLY A 576
 None
 0.86A 5x5qE-4fn5A:
undetectable		 5x5qE-4fn5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ILE A 459
ASP A 382
LEU A 423
GLY A 381
 None
 0.99A 5x5qE-4fnqA:
undetectable		 5x5qE-4fnqA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00303
(Thymidylat_synt) 		4 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.50A 5x5qE-4fogA:
36.8		 5x5qE-4fogA:
50.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PHE A 129
ILE A 117
LEU A 133
GLY A 147
 None
 0.98A 5x5qE-4fspA:
undetectable		 5x5qE-4fspA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gib BETA-PHOSPHOGLUCOMUT
ASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		4 PHE A   7
ILE A  97
GLY A  11
TYR A  19
 None
None
NA  A 302 ( 4.7A)
None
 0.87A 5x5qE-4gibA:
undetectable		 5x5qE-4gibA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum) 		PF00303
(Thymidylat_synt) 		4 ASP A 172
LEU A 175
GLY A 176
TYR A 212
 None
None
UMP  A 301 (-3.6A)
UMP  A 301 (-4.5A)
 0.68A 5x5qE-4h0uA:
35.4		 5x5qE-4h0uA:
47.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum) 		PF00303
(Thymidylat_synt) 		4 ILE A  82
ASP A 172
GLY A 176
TYR A 212
 None
None
UMP  A 301 (-3.6A)
UMP  A 301 (-4.5A)
 0.53A 5x5qE-4h0uA:
35.4		 5x5qE-4h0uA:
47.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		5 PHE A 150
ILE A 151
ASP A 232
LEU A 184
GLY A 144
 None
 1.39A 5x5qE-4h1xA:
undetectable		 5x5qE-4h1xA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		4 ILE A 292
LEU A  36
GLY A  37
TYR A  24
 None
 0.79A 5x5qE-4ijrA:
undetectable		 5x5qE-4ijrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ily CHITOSANASE

(Streptomyces
sp. SirexAA-E) 		PF01374
(Glyco_hydro_46) 		4 ILE A  65
ASP A  58
LEU A  57
GLY A  56
 None
 0.96A 5x5qE-4ilyA:
undetectable		 5x5qE-4ilyA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		5 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.24A 5x5qE-4iqqA:
42.7		 5x5qE-4iqqA:
62.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5q O-ACETYL-ADP-RIBOSE
DEACETYLASE 1

(Homo sapiens) 		PF01661
(Macro) 		4 PHE A  48
ILE A  78
LEU A  58
GLY A  54
 None
 0.64A 5x5qE-4j5qA:
undetectable		 5x5qE-4j5qA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 ILE A 236
LEU A 251
GLY A 228
TYR A 405
 None
 0.92A 5x5qE-4jz6A:
undetectable		 5x5qE-4jz6A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica) 		PF03372
(Exo_endo_phos) 		4 ILE F 124
ASP F 131
LEU F 151
GLY F 150
 None
 0.79A 5x5qE-4k6lF:
undetectable		 5x5qE-4k6lF:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9z MALYL-COA LYASE

(Rhodobacter
sphaeroides) 		PF03328
(HpcH_HpaI) 		4 PHE A  28
ILE A  59
ASP A 101
LEU A  73
 None
 1.01A 5x5qE-4l9zA:
undetectable		 5x5qE-4l9zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE

([Clostridium]
scindens) 		PF00501
(AMP-binding) 		4 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.79A 5x5qE-4lgcA:
undetectable		 5x5qE-4lgcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3k CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-H7S

(Lama glama) 		PF07686
(V-set) 		4 PHE B  98
LEU B  50
GLY B  35
TYR B  59
 None
 0.88A 5x5qE-4m3kB:
undetectable		 5x5qE-4m3kB:
16.38