SIMILAR PATTERNS OF AMINO ACIDS FOR 5X2T_I_PEMI202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A  86
THR A  90
THR A  93
ALA A 407
 None
 1.02A 5x2tI-1b3bA:
undetectable
5x2tJ-1b3bA:
undetectable
5x2tK-1b3bA:
undetectable
5x2tL-1b3bA:
undetectable		 5x2tI-1b3bA:
18.09
5x2tJ-1b3bA:
17.75
5x2tK-1b3bA:
18.09
5x2tL-1b3bA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		4 PRO A 253
THR A 192
THR A 195
ALA A 158
 None
 1.00A 5x2tI-1bg6A:
undetectable
5x2tJ-1bg6A:
undetectable
5x2tK-1bg6A:
undetectable
5x2tL-1bg6A:
undetectable		 5x2tI-1bg6A:
17.66
5x2tJ-1bg6A:
22.55
5x2tK-1bg6A:
17.66
5x2tL-1bg6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		4 PRO A 183
ALA A 244
THR A 265
ALA A 286
 None
 0.97A 5x2tI-1bueA:
undetectable
5x2tJ-1bueA:
undetectable
5x2tK-1bueA:
undetectable
5x2tL-1bueA:
undetectable		 5x2tI-1bueA:
17.98
5x2tJ-1bueA:
18.90
5x2tK-1bueA:
17.98
5x2tL-1bueA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A  86
THR A  90
THR A  93
ALA A 409
 None
 0.93A 5x2tI-1bvuA:
undetectable
5x2tJ-1bvuA:
undetectable
5x2tK-1bvuA:
undetectable
5x2tL-1bvuA:
undetectable		 5x2tI-1bvuA:
16.39
5x2tJ-1bvuA:
16.79
5x2tK-1bvuA:
16.39
5x2tL-1bvuA:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA

(Homo sapiens) 		PF00042
(Globin) 		4 PRO A 100
ALA A 135
THR A 139
THR A 142
 None
 0.27A 5x2tI-1ch4A:
21.7
5x2tJ-1ch4A:
25.4
5x2tK-1ch4A:
21.9
5x2tL-1ch4A:
24.1		 5x2tI-1ch4A:
60.81
5x2tJ-1ch4A:
82.19
5x2tK-1ch4A:
60.81
5x2tL-1ch4A:
82.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		4 PRO A 183
ALA A 244
THR A 265
ALA A 286
 None
 0.94A 5x2tI-1dy6A:
undetectable
5x2tJ-1dy6A:
undetectable
5x2tK-1dy6A:
undetectable
5x2tL-1dy6A:
undetectable		 5x2tI-1dy6A:
17.84
5x2tJ-1dy6A:
21.54
5x2tK-1dy6A:
17.84
5x2tL-1dy6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		4 ALA A 157
THR A 160
THR A 313
ALA A 350
 None
 0.98A 5x2tI-1e5fA:
undetectable
5x2tJ-1e5fA:
undetectable
5x2tK-1e5fA:
undetectable
5x2tL-1e5fA:
undetectable		 5x2tI-1e5fA:
17.13
5x2tJ-1e5fA:
13.76
5x2tK-1e5fA:
17.13
5x2tL-1e5fA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 PRO B  98
ALA B 106
THR B 131
ALA A 103
 AMP  A 400 ( 4.6A)
None
AMP  A 400 (-3.3A)
None
 1.03A 5x2tI-1efpB:
undetectable
5x2tJ-1efpB:
undetectable
5x2tK-1efpB:
undetectable
5x2tL-1efpB:
undetectable		 5x2tI-1efpB:
23.11
5x2tJ-1efpB:
19.43
5x2tK-1efpB:
23.11
5x2tL-1efpB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 PRO A 193
ALA A  45
THR A 188
THR A 191
 None
GLC  A3100 ( 3.9A)
None
None
 1.02A 5x2tI-1fbwA:
undetectable
5x2tJ-1fbwA:
undetectable
5x2tK-1fbwA:
undetectable
5x2tL-1fbwA:
undetectable		 5x2tI-1fbwA:
11.98
5x2tJ-1fbwA:
12.70
5x2tK-1fbwA:
11.98
5x2tL-1fbwA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 PRO A 107
ALA A 122
THR A 126
THR A 129
 None
 0.85A 5x2tI-1g68A:
undetectable
5x2tJ-1g68A:
undetectable
5x2tK-1g68A:
undetectable
5x2tL-1g68A:
undetectable		 5x2tI-1g68A:
21.03
5x2tJ-1g68A:
21.65
5x2tK-1g68A:
21.03
5x2tL-1g68A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 380
THR A 383
TRP A  54
ALA A 220
 None
 1.03A 5x2tI-1geuA:
undetectable
5x2tJ-1geuA:
undetectable
5x2tK-1geuA:
undetectable
5x2tL-1geuA:
undetectable		 5x2tI-1geuA:
15.33
5x2tJ-1geuA:
18.14
5x2tK-1geuA:
15.33
5x2tL-1geuA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A  86
THR A  90
THR A  93
ALA A 410
 None
 0.92A 5x2tI-1gtmA:
undetectable
5x2tJ-1gtmA:
undetectable
5x2tK-1gtmA:
undetectable
5x2tL-1gtmA:
undetectable		 5x2tI-1gtmA:
16.79
5x2tJ-1gtmA:
16.90
5x2tK-1gtmA:
16.79
5x2tL-1gtmA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		4 PRO A 307
ALA A 303
THR A 301
TRP A 310
 None
 0.81A 5x2tI-1hdiA:
undetectable
5x2tJ-1hdiA:
undetectable
5x2tK-1hdiA:
undetectable
5x2tL-1hdiA:
undetectable		 5x2tI-1hdiA:
17.76
5x2tJ-1hdiA:
16.80
5x2tK-1hdiA:
17.76
5x2tL-1hdiA:
16.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		5 PRO A  95
ALA A 130
THR A 134
THR A 137
TRP B  36
 None
 0.58A 5x2tI-1hdsA:
24.0
5x2tJ-1hdsA:
20.0
5x2tK-1hdsA:
24.0
5x2tL-1hdsA:
18.5		 5x2tI-1hdsA:
77.30
5x2tJ-1hdsA:
41.22
5x2tK-1hdsA:
77.30
5x2tL-1hdsA:
41.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ALA A 183
THR A 185
THR A 293
ALA A 285
 None
 0.89A 5x2tI-1mpxA:
undetectable
5x2tJ-1mpxA:
undetectable
5x2tK-1mpxA:
undetectable
5x2tL-1mpxA:
undetectable		 5x2tI-1mpxA:
13.17
5x2tJ-1mpxA:
15.80
5x2tK-1mpxA:
13.17
5x2tL-1mpxA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 PRO A 143
THR A 139
ALA A 300
TRP A 136
 None
 0.95A 5x2tI-1np7A:
undetectable
5x2tJ-1np7A:
undetectable
5x2tK-1np7A:
undetectable
5x2tL-1np7A:
undetectable		 5x2tI-1np7A:
13.42
5x2tJ-1np7A:
15.32
5x2tK-1np7A:
13.42
5x2tL-1np7A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		4 ALA A  65
THR A 230
ALA A 102
TRP A  84
 None
 0.96A 5x2tI-1nrkA:
undetectable
5x2tJ-1nrkA:
undetectable
5x2tK-1nrkA:
undetectable
5x2tL-1nrkA:
undetectable		 5x2tI-1nrkA:
16.77
5x2tJ-1nrkA:
18.04
5x2tK-1nrkA:
16.77
5x2tL-1nrkA:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1j HEMOGLOBIN ALPHA
CHAIN

(Homo sapiens) 		PF00042
(Globin) 		5 PRO A  95
ALA A 130
THR A 134
THR A 137
ALA A 272
 None
 0.28A 5x2tI-1o1jA:
27.2
5x2tJ-1o1jA:
21.4
5x2tK-1o1jA:
27.3
5x2tL-1o1jA:
20.3		 5x2tI-1o1jA:
98.58
5x2tJ-1o1jA:
24.48
5x2tK-1o1jA:
98.58
5x2tL-1o1jA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1j HEMOGLOBIN ALPHA
CHAIN

(Homo sapiens) 		PF00042
(Globin) 		5 PRO A 237
ALA A 272
THR A 276
THR A 279
ALA A 130
 None
 0.31A 5x2tI-1o1jA:
27.2
5x2tJ-1o1jA:
21.4
5x2tK-1o1jA:
27.3
5x2tL-1o1jA:
20.3		 5x2tI-1o1jA:
98.58
5x2tJ-1o1jA:
24.48
5x2tK-1o1jA:
98.58
5x2tL-1o1jA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpw PORCINE HEMOGLOBIN
(ALPHA SUBUNIT)
PORCINE HEMOGLOBIN
(BETA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		5 PRO A  95
ALA A 130
THR A 134
THR A 137
TRP B  37
 None
 0.55A 5x2tI-1qpwA:
26.2
5x2tJ-1qpwA:
21.2
5x2tK-1qpwA:
26.1
5x2tL-1qpwA:
19.9		 5x2tI-1qpwA:
84.40
5x2tJ-1qpwA:
41.22
5x2tK-1qpwA:
84.40
5x2tL-1qpwA:
41.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 PRO 1 591
THR 1 223
THR 1 224
ALA 1 337
 None
 1.04A 5x2tI-1y791:
undetectable
5x2tJ-1y791:
undetectable
5x2tK-1y791:
undetectable
5x2tL-1y791:
undetectable		 5x2tI-1y791:
11.60
5x2tJ-1y791:
12.72
5x2tK-1y791:
11.60
5x2tL-1y791:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		4 THR A1366
THR A1408
ALA A1505
TRP A1035
 None
 1.00A 5x2tI-1yrzA:
undetectable
5x2tJ-1yrzA:
undetectable
5x2tK-1yrzA:
undetectable
5x2tL-1yrzA:
undetectable		 5x2tI-1yrzA:
17.23
5x2tJ-1yrzA:
14.23
5x2tK-1yrzA:
17.23
5x2tL-1yrzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1n SIXTEEN HEME
CYTOCHROME

(Desulfovibrio
gigas) 		PF02085
(Cytochrom_CIII)
PF14522
(Cytochrome_C7) 		4 ALA X 230
THR X 227
THR X 120
ALA X  15
 None
 0.98A 5x2tI-1z1nX:
undetectable
5x2tJ-1z1nX:
undetectable
5x2tK-1z1nX:
undetectable
5x2tL-1z1nX:
undetectable		 5x2tI-1z1nX:
13.89
5x2tJ-1z1nX:
15.40
5x2tK-1z1nX:
13.89
5x2tL-1z1nX:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 ALA A 165
THR A 162
THR A 195
ALA A 184
 SAH  A4001 (-3.4A)
None
None
None
 1.01A 5x2tI-2a14A:
undetectable
5x2tJ-2a14A:
undetectable
5x2tK-2a14A:
undetectable
5x2tL-2a14A:
undetectable		 5x2tI-2a14A:
20.16
5x2tJ-2a14A:
19.16
5x2tK-2a14A:
20.16
5x2tL-2a14A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 ALA A 420
THR A 417
THR A 468
ALA A 312
 COA  A2600 ( 4.3A)
COA  A2600 ( 4.8A)
None
None
 1.03A 5x2tI-2ahwA:
undetectable
5x2tJ-2ahwA:
undetectable
5x2tK-2ahwA:
undetectable
5x2tL-2ahwA:
undetectable		 5x2tI-2ahwA:
13.49
5x2tJ-2ahwA:
15.20
5x2tK-2ahwA:
13.49
5x2tL-2ahwA:
15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b7h HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 PRO A  95
THR A 134
THR A 137
TRP B  37
 None
 0.55A 5x2tI-2b7hA:
25.9
5x2tJ-2b7hA:
21.9
5x2tK-2b7hA:
26.3
5x2tL-2b7hA:
20.1		 5x2tI-2b7hA:
82.98
5x2tJ-2b7hA:
43.24
5x2tK-2b7hA:
82.98
5x2tL-2b7hA:
43.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		4 PRO A 246
ALA A 238
THR A 241
ALA A 262
 None
 0.98A 5x2tI-2i4cA:
undetectable
5x2tJ-2i4cA:
undetectable
5x2tK-2i4cA:
undetectable
5x2tL-2i4cA:
undetectable		 5x2tI-2i4cA:
15.38
5x2tJ-2i4cA:
16.32
5x2tK-2i4cA:
15.38
5x2tL-2i4cA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		4 PRO A 266
ALA A 109
THR A 215
ALA A 182
 None
 1.00A 5x2tI-2imrA:
undetectable
5x2tJ-2imrA:
undetectable
5x2tK-2imrA:
undetectable
5x2tL-2imrA:
undetectable		 5x2tI-2imrA:
15.95
5x2tJ-2imrA:
17.35
5x2tK-2imrA:
15.95
5x2tL-2imrA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lyi PROTEIN (ENTITY)

(Nephila
antipodiana) 		PF12042
(RP1-2) 		4 ALA A  13
THR A  17
THR A  19
ALA A  27
 None
 0.87A 5x2tI-2lyiA:
4.1
5x2tJ-2lyiA:
3.7
5x2tK-2lyiA:
4.3
5x2tL-2lyiA:
3.8		 5x2tI-2lyiA:
24.44
5x2tJ-2lyiA:
24.57
5x2tK-2lyiA:
24.44
5x2tL-2lyiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PRO A 150
ALA A 135
THR A  99
ALA A 112
 None
 0.99A 5x2tI-2qquA:
undetectable
5x2tJ-2qquA:
undetectable
5x2tK-2qquA:
undetectable
5x2tL-2qquA:
undetectable		 5x2tI-2qquA:
14.48
5x2tJ-2qquA:
14.89
5x2tK-2qquA:
14.48
5x2tL-2qquA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ALA A 156
THR A 152
ALA A 181
TRP A 393
 None
 1.02A 5x2tI-2v7gA:
undetectable
5x2tJ-2v7gA:
undetectable
5x2tK-2v7gA:
undetectable
5x2tL-2v7gA:
undetectable		 5x2tI-2v7gA:
13.36
5x2tJ-2v7gA:
13.92
5x2tK-2v7gA:
13.36
5x2tL-2v7gA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PRO B 306
THR B 460
TRP B 674
ALA B 528
 HPA  B1780 (-4.8A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
 1.01A 5x2tI-2w55B:
undetectable
5x2tJ-2w55B:
undetectable
5x2tK-2w55B:
undetectable
5x2tL-2w55B:
undetectable		 5x2tI-2w55B:
11.04
5x2tJ-2w55B:
10.86
5x2tK-2w55B:
11.04
5x2tL-2w55B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 ALA A  12
THR A  49
THR A  95
ALA A  67
 MET  A 600 (-3.8A)
None
None
None
 0.95A 5x2tI-2x1mA:
undetectable
5x2tJ-2x1mA:
undetectable
5x2tK-2x1mA:
undetectable
5x2tL-2x1mA:
undetectable		 5x2tI-2x1mA:
15.19
5x2tJ-2x1mA:
15.69
5x2tK-2x1mA:
15.19
5x2tL-2x1mA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 ALA A  12
THR A  49
THR A  95
ALA A  68
 MET  A 600 (-3.8A)
None
None
None
 0.87A 5x2tI-2x1mA:
undetectable
5x2tJ-2x1mA:
undetectable
5x2tK-2x1mA:
undetectable
5x2tL-2x1mA:
undetectable		 5x2tI-2x1mA:
15.19
5x2tJ-2x1mA:
15.69
5x2tK-2x1mA:
15.19
5x2tL-2x1mA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 ALA A  87
THR A  91
THR A  94
TRP A 152
 None
 0.80A 5x2tI-2xdrA:
undetectable
5x2tJ-2xdrA:
undetectable
5x2tK-2xdrA:
undetectable
5x2tL-2xdrA:
undetectable		 5x2tI-2xdrA:
16.38
5x2tJ-2xdrA:
16.53
5x2tK-2xdrA:
16.38
5x2tL-2xdrA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		4 PRO A 197
ALA A 253
THR A 151
ALA A 117
 None
 1.01A 5x2tI-2xrmA:
undetectable
5x2tJ-2xrmA:
undetectable
5x2tK-2xrmA:
undetectable
5x2tL-2xrmA:
undetectable		 5x2tI-2xrmA:
20.48
5x2tJ-2xrmA:
16.35
5x2tK-2xrmA:
20.48
5x2tL-2xrmA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ALA A 663
THR A 665
THR A 668
ALA A 682
 None
 0.89A 5x2tI-2xsgA:
undetectable
5x2tJ-2xsgA:
undetectable
5x2tK-2xsgA:
undetectable
5x2tL-2xsgA:
undetectable		 5x2tI-2xsgA:
11.71
5x2tJ-2xsgA:
11.07
5x2tK-2xsgA:
11.71
5x2tL-2xsgA:
11.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a0g HEMOGLOBIN SUBUNIT
ALPHA

(Cavia porcellus) 		PF00042
(Globin) 		4 PRO A  95
ALA A 130
THR A 134
THR A 137
 None
 0.49A 5x2tI-3a0gA:
25.1
5x2tJ-3a0gA:
20.9
5x2tK-3a0gA:
25.1
5x2tL-3a0gA:
19.6		 5x2tI-3a0gA:
75.89
5x2tJ-3a0gA:
38.00
5x2tK-3a0gA:
75.89
5x2tL-3a0gA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a0g HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		4 PRO A  95
ALA A 130
THR A 134
TRP B  37
 None
 0.81A 5x2tI-3a0gA:
25.1
5x2tJ-3a0gA:
20.9
5x2tK-3a0gA:
25.1
5x2tL-3a0gA:
19.6		 5x2tI-3a0gA:
75.89
5x2tJ-3a0gA:
38.00
5x2tK-3a0gA:
75.89
5x2tL-3a0gA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		4 PRO A 175
ALA A  70
ALA A 257
TRP A 166
 None
 1.01A 5x2tI-3a3uA:
undetectable
5x2tJ-3a3uA:
undetectable
5x2tK-3a3uA:
undetectable
5x2tL-3a3uA:
undetectable		 5x2tI-3a3uA:
22.06
5x2tJ-3a3uA:
24.26
5x2tK-3a3uA:
22.06
5x2tL-3a3uA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 PRO A 342
ALA A 185
THR A 361
ALA A 126
 None
EDO  A 489 ( 3.7A)
EDO  A 489 (-4.3A)
None
 1.01A 5x2tI-3b9tA:
undetectable
5x2tJ-3b9tA:
undetectable
5x2tK-3b9tA:
undetectable
5x2tL-3b9tA:
undetectable		 5x2tI-3b9tA:
16.03
5x2tJ-3b9tA:
20.06
5x2tK-3b9tA:
16.03
5x2tL-3b9tA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d1a HEMOGLOBIN SUBUNIT
ALPHA-1/2

(Capra hircus) 		PF00042
(Globin) 		4 PRO A  95
ALA A 130
THR A 134
THR A 137
 None
 0.59A 5x2tI-3d1aA:
26.5
5x2tJ-3d1aA:
21.9
5x2tK-3d1aA:
26.4
5x2tL-3d1aA:
20.5		 5x2tI-3d1aA:
86.52
5x2tJ-3d1aA:
43.24
5x2tK-3d1aA:
86.52
5x2tL-3d1aA:
43.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP3

(Rhinovirus A) 		PF00073
(Rhv) 		4 PRO C 199
ALA C 206
THR C 202
TRP C 155
 None
 1.01A 5x2tI-3dprC:
undetectable
5x2tJ-3dprC:
undetectable
5x2tK-3dprC:
undetectable
5x2tL-3dprC:
undetectable		 5x2tI-3dprC:
21.11
5x2tJ-3dprC:
19.57
5x2tK-3dprC:
21.11
5x2tL-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		4 PRO A 205
ALA A 247
THR A 217
ALA A 155
 None
 0.95A 5x2tI-3e0gA:
undetectable
5x2tJ-3e0gA:
undetectable
5x2tK-3e0gA:
undetectable
5x2tL-3e0gA:
undetectable		 5x2tI-3e0gA:
14.85
5x2tJ-3e0gA:
18.89
5x2tK-3e0gA:
14.85
5x2tL-3e0gA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eet PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00392
(GntR)
PF07702
(UTRA) 		4 ALA A 156
THR A 158
THR A 161
ALA A 181
 None
 1.03A 5x2tI-3eetA:
undetectable
5x2tJ-3eetA:
undetectable
5x2tK-3eetA:
undetectable
5x2tL-3eetA:
undetectable		 5x2tI-3eetA:
18.18
5x2tJ-3eetA:
20.22
5x2tK-3eetA:
18.18
5x2tL-3eetA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		4 ALA A  92
THR A  96
ALA A 286
TRP A 157
 None
 0.66A 5x2tI-3ek1A:
undetectable
5x2tJ-3ek1A:
undetectable
5x2tK-3ek1A:
undetectable
5x2tL-3ek1A:
undetectable		 5x2tI-3ek1A:
15.89
5x2tJ-3ek1A:
14.74
5x2tK-3ek1A:
15.89
5x2tL-3ek1A:
14.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fh9 HEMOGLOBIN ALPHA
CHAIN

(Pteropus
giganteus) 		PF00042
(Globin) 		4 PRO A  95
ALA A 130
THR A 134
THR A 137
 None
 0.55A 5x2tI-3fh9A:
24.3
5x2tJ-3fh9A:
20.1
5x2tK-3fh9A:
24.5
5x2tL-3fh9A:
18.8		 5x2tI-3fh9A:
86.52
5x2tJ-3fh9A:
44.59
5x2tK-3fh9A:
86.52
5x2tL-3fh9A:
44.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		4 ALA A 255
THR A 259
THR A 262
ALA A  24
 None
 0.97A 5x2tI-3fhxA:
undetectable
5x2tJ-3fhxA:
undetectable
5x2tK-3fhxA:
undetectable
5x2tL-3fhxA:
undetectable		 5x2tI-3fhxA:
17.63
5x2tJ-3fhxA:
19.18
5x2tK-3fhxA:
17.63
5x2tL-3fhxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		4 ALA A 255
THR A 259
THR A 262
ALA A 235
 None
None
None
SO4  A 314 (-3.6A)
 0.95A 5x2tI-3fhxA:
undetectable
5x2tJ-3fhxA:
undetectable
5x2tK-3fhxA:
undetectable
5x2tL-3fhxA:
undetectable		 5x2tI-3fhxA:
17.63
5x2tJ-3fhxA:
19.18
5x2tK-3fhxA:
17.63
5x2tL-3fhxA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gdj HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA

(Camelus
dromedarius) 		PF00042
(Globin) 		5 PRO A  95
ALA A 130
THR A 134
THR A 137
TRP B  37
 None
 0.61A 5x2tI-3gdjA:
26.0
5x2tJ-3gdjA:
21.9
5x2tK-3gdjA:
25.9
5x2tL-3gdjA:
20.2		 5x2tI-3gdjA:
84.40
5x2tJ-3gdjA:
42.95
5x2tK-3gdjA:
84.40
5x2tL-3gdjA:
42.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gqp HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA-A/B

(Felis catus) 		PF00042
(Globin) 		4 PRO A  95
THR A 134
THR A 137
TRP B  37
 None
 0.60A 5x2tI-3gqpA:
25.5
5x2tJ-3gqpA:
21.2
5x2tK-3gqpA:
25.8
5x2tL-3gqpA:
19.8		 5x2tI-3gqpA:
85.11
5x2tJ-3gqpA:
41.89
5x2tK-3gqpA:
85.11
5x2tL-3gqpA:
41.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtz PUTATIVE TRANSLATION
INITIATION INHIBITOR

(Salmonella
enterica) 		PF01042
(Ribonuc_L-PSP) 		4 ALA A  35
THR A  39
THR A  42
ALA A  63
 None
 0.71A 5x2tI-3gtzA:
undetectable
5x2tJ-3gtzA:
undetectable
5x2tK-3gtzA:
undetectable
5x2tL-3gtzA:
undetectable		 5x2tI-3gtzA:
16.78
5x2tJ-3gtzA:
24.84
5x2tK-3gtzA:
16.78
5x2tL-3gtzA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 PRO A 504
ALA A 510
THR A 113
THR A 116
 None
 0.86A 5x2tI-3i6sA:
undetectable
5x2tJ-3i6sA:
undetectable
5x2tK-3i6sA:
undetectable
5x2tL-3i6sA:
undetectable		 5x2tI-3i6sA:
13.23
5x2tJ-3i6sA:
12.78
5x2tK-3i6sA:
13.23
5x2tL-3i6sA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 PRO W 454
ALA W 673
THR W 671
ALA W 636
 None
 0.94A 5x2tI-3iylW:
undetectable
5x2tJ-3iylW:
undetectable
5x2tK-3iylW:
undetectable
5x2tL-3iylW:
undetectable		 5x2tI-3iylW:
8.68
5x2tJ-3iylW:
7.43
5x2tK-3iylW:
8.68
5x2tL-3iylW:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		4 ALA A  90
THR A  94
ALA A 284
TRP A 155
 None
None
None
NAP  A 482 (-3.9A)
 0.66A 5x2tI-3jz4A:
undetectable
5x2tJ-3jz4A:
undetectable
5x2tK-3jz4A:
undetectable
5x2tL-3jz4A:
undetectable		 5x2tI-3jz4A:
17.13
5x2tJ-3jz4A:
16.70
5x2tK-3jz4A:
17.13
5x2tL-3jz4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 PRO A 192
ALA A 178
THR A 155
THR A 136
ALA A 159
 None
 1.35A 5x2tI-3ldrA:
undetectable
5x2tJ-3ldrA:
undetectable
5x2tK-3ldrA:
undetectable
5x2tL-3ldrA:
undetectable		 5x2tI-3ldrA:
11.11
5x2tJ-3ldrA:
11.99
5x2tK-3ldrA:
11.11
5x2tL-3ldrA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
marinum) 		PF00797
(Acetyltransf_2) 		4 ALA A 150
THR A 136
ALA A 211
TRP A  97
 None
 0.93A 5x2tI-3ltwA:
undetectable
5x2tJ-3ltwA:
undetectable
5x2tK-3ltwA:
undetectable
5x2tL-3ltwA:
undetectable		 5x2tI-3ltwA:
20.57
5x2tJ-3ltwA:
18.84
5x2tK-3ltwA:
20.57
5x2tL-3ltwA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ALA A 298
THR A 302
THR A 304
ALA A 166
 None
 0.84A 5x2tI-3o7qA:
undetectable
5x2tJ-3o7qA:
undetectable
5x2tK-3o7qA:
undetectable
5x2tL-3o7qA:
undetectable		 5x2tI-3o7qA:
14.35
5x2tJ-3o7qA:
16.58
5x2tK-3o7qA:
14.35
5x2tL-3o7qA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PRO A 164
ALA A 157
TRP A 427
ALA A 281
 None
 0.97A 5x2tI-3tktA:
undetectable
5x2tJ-3tktA:
undetectable
5x2tK-3tktA:
undetectable
5x2tL-3tktA:
undetectable		 5x2tI-3tktA:
15.92
5x2tJ-3tktA:
15.67
5x2tK-3tktA:
15.92
5x2tL-3tktA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		4 PRO A 259
ALA A 155
THR A 159
ALA A 264
 None
 0.98A 5x2tI-3ubmA:
undetectable
5x2tJ-3ubmA:
undetectable
5x2tK-3ubmA:
undetectable
5x2tL-3ubmA:
undetectable		 5x2tI-3ubmA:
14.32
5x2tJ-3ubmA:
18.44
5x2tK-3ubmA:
14.32
5x2tL-3ubmA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 PRO A1261
ALA A1090
ALA A1219
TRP A1283
 None
 0.91A 5x2tI-3ummA:
undetectable
5x2tJ-3ummA:
undetectable
5x2tK-3ummA:
undetectable
5x2tL-3ummA:
undetectable		 5x2tI-3ummA:
8.01
5x2tJ-3ummA:
8.04
5x2tK-3ummA:
8.01
5x2tL-3ummA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7b UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF09449
(DUF2020) 		4 PRO A  13
ALA A  63
THR A  67
ALA A  86
 None
EDO  A 401 ( 3.7A)
EDO  A 401 (-3.5A)
None
 0.78A 5x2tI-3v7bA:
undetectable
5x2tJ-3v7bA:
undetectable
5x2tK-3v7bA:
undetectable
5x2tL-3v7bA:
undetectable		 5x2tI-3v7bA:
21.64
5x2tJ-3v7bA:
20.00
5x2tK-3v7bA:
21.64
5x2tL-3v7bA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		4 PRO A  95
THR A 134
THR A 137
TRP B  37
 None
 0.65A 5x2tI-3vreA:
26.5
5x2tJ-3vreA:
21.5
5x2tK-3vreA:
27.2
5x2tL-3vreA:
20.2		 5x2tI-3vreA:
82.98
5x2tJ-3vreA:
40.94
5x2tK-3vreA:
82.98
5x2tL-3vreA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		4 PRO A 353
THR A 313
THR A 316
ALA A 336
 None
 0.91A 5x2tI-4atbA:
undetectable
5x2tJ-4atbA:
undetectable
5x2tK-4atbA:
undetectable
5x2tL-4atbA:
undetectable		 5x2tI-4atbA:
19.82
5x2tJ-4atbA:
21.14
5x2tK-4atbA:
19.82
5x2tL-4atbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ALA A 210
THR A 202
TRP A 194
ALA A   4
 None
None
BTB  A 315 ( 4.9A)
None
 1.04A 5x2tI-4awnA:
undetectable
5x2tJ-4awnA:
undetectable
5x2tK-4awnA:
undetectable
5x2tL-4awnA:
undetectable		 5x2tI-4awnA:
20.50
5x2tJ-4awnA:
21.58
5x2tK-4awnA:
20.50
5x2tL-4awnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE

(Methylomicrobium
album) 		no annotation 4 PRO A  92
ALA A 221
THR A 223
THR A  85
 None
 1.03A 5x2tI-4bz4A:
undetectable
5x2tJ-4bz4A:
undetectable
5x2tK-4bz4A:
undetectable
5x2tL-4bz4A:
undetectable		 5x2tI-4bz4A:
18.86
5x2tJ-4bz4A:
22.51
5x2tK-4bz4A:
18.86
5x2tL-4bz4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ALA A 195
THR A 253
TRP A 144
ALA A 169
 None
None
None
CL  A1493 ( 3.7A)
 0.99A 5x2tI-4cnsA:
undetectable
5x2tJ-4cnsA:
undetectable
5x2tK-4cnsA:
undetectable
5x2tL-4cnsA:
undetectable		 5x2tI-4cnsA:
14.53
5x2tJ-4cnsA:
13.33
5x2tK-4cnsA:
14.53
5x2tL-4cnsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ALA A 195
THR A 253
TRP A 144
ALA A 169
 None
None
EDO  A1497 (-4.2A)
None
 1.02A 5x2tI-4cntA:
undetectable
5x2tJ-4cntA:
undetectable
5x2tK-4cntA:
undetectable
5x2tL-4cntA:
undetectable		 5x2tI-4cntA:
14.39
5x2tJ-4cntA:
13.03
5x2tK-4cntA:
14.39
5x2tL-4cntA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 PRO A 315
ALA A 215
TRP A 188
ALA A  55
 None
 1.04A 5x2tI-4cvcA:
undetectable
5x2tJ-4cvcA:
undetectable
5x2tK-4cvcA:
undetectable
5x2tL-4cvcA:
undetectable		 5x2tI-4cvcA:
14.31
5x2tJ-4cvcA:
13.59
5x2tK-4cvcA:
14.31
5x2tL-4cvcA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF13458
(Peripla_BP_6) 		4 PRO A 138
ALA A 120
THR A 117
ALA A  59
 None
None
ILE  A 401 (-4.1A)
None
 0.99A 5x2tI-4gnrA:
undetectable
5x2tJ-4gnrA:
undetectable
5x2tK-4gnrA:
undetectable
5x2tL-4gnrA:
undetectable		 5x2tI-4gnrA:
17.73
5x2tJ-4gnrA:
18.58
5x2tK-4gnrA:
17.73
5x2tL-4gnrA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
multivorans) 		PF13561
(adh_short_C2) 		4 ALA A  73
THR A  77
THR A  80
ALA A  57
 None
 0.93A 5x2tI-4gvxA:
undetectable
5x2tJ-4gvxA:
undetectable
5x2tK-4gvxA:
undetectable
5x2tL-4gvxA:
undetectable		 5x2tI-4gvxA:
22.31
5x2tJ-4gvxA:
18.99
5x2tK-4gvxA:
22.31
5x2tL-4gvxA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h2l ALPHA-GLOBIN
BETA GLOBIN

(Peromyscus
maniculatus) 		PF00042
(Globin) 		5 PRO A  95
ALA A 130
THR A 134
THR A 137
TRP B  37
 None
 0.60A 5x2tI-4h2lA:
26.3
5x2tJ-4h2lA:
22.1
5x2tK-4h2lA:
26.3
5x2tL-4h2lA:
20.5		 5x2tI-4h2lA:
85.11
5x2tJ-4h2lA:
40.54
5x2tK-4h2lA:
85.11
5x2tL-4h2lA:
40.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		4 PRO A  42
ALA A 192
THR A 217
ALA A 200
 None
NA  A 602 ( 4.6A)
None
None
 0.97A 5x2tI-4i8pA:
undetectable
5x2tJ-4i8pA:
undetectable
5x2tK-4i8pA:
undetectable
5x2tL-4i8pA:
undetectable		 5x2tI-4i8pA:
14.81
5x2tJ-4i8pA:
14.17
5x2tK-4i8pA:
14.81
5x2tL-4i8pA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp9 PAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 PRO A 209
ALA A  27
THR A  33
ALA A 105
 None
 1.00A 5x2tI-4kp9A:
undetectable
5x2tJ-4kp9A:
undetectable
5x2tK-4kp9A:
undetectable
5x2tL-4kp9A:
undetectable		 5x2tI-4kp9A:
19.72
5x2tJ-4kp9A:
20.00
5x2tK-4kp9A:
19.72
5x2tL-4kp9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lly MUTATED PERTUZUMAB
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO A  53
ALA A  49
THR A  33
ALA A  24
 None
 1.03A 5x2tI-4llyA:
undetectable
5x2tJ-4llyA:
undetectable
5x2tK-4llyA:
undetectable
5x2tL-4llyA:
undetectable		 5x2tI-4llyA:
17.16
5x2tJ-4llyA:
16.67
5x2tK-4llyA:
17.16
5x2tL-4llyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mob ACYL-COENZYME A
THIOESTERASE 12

(Homo sapiens) 		PF03061
(4HBT) 		4 ALA A 207
THR A 211
THR A 214
ALA A  22
 None
 0.84A 5x2tI-4mobA:
undetectable
5x2tJ-4mobA:
undetectable
5x2tK-4mobA:
undetectable
5x2tL-4mobA:
undetectable		 5x2tI-4mobA:
19.09
5x2tJ-4mobA:
20.24
5x2tK-4mobA:
19.09
5x2tL-4mobA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E

(Aeropyrum
pernix) 		PF01040
(UbiA) 		4 ALA A 231
THR A 235
THR A 238
ALA A 166
 None
 0.89A 5x2tI-4od5A:
undetectable
5x2tJ-4od5A:
undetectable
5x2tK-4od5A:
undetectable
5x2tL-4od5A:
undetectable		 5x2tI-4od5A:
19.93
5x2tJ-4od5A:
18.69
5x2tK-4od5A:
19.93
5x2tL-4od5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 ALA A  67
THR A  71
ALA A 259
TRP A 131
 None
None
None
NAP  A 501 (-4.3A)
 0.73A 5x2tI-4ohtA:
undetectable
5x2tJ-4ohtA:
undetectable
5x2tK-4ohtA:
undetectable
5x2tL-4ohtA:
undetectable		 5x2tI-4ohtA:
15.38
5x2tJ-4ohtA:
15.49
5x2tK-4ohtA:
15.38
5x2tL-4ohtA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcg VP1

(Human
polyomavirus 6) 		PF00718
(Polyoma_coat) 		4 ALA A 185
THR A  77
THR A 246
ALA A  40
 SCN  A 301 (-3.5A)
SCN  A 301 ( 4.2A)
None
SCN  A 303 (-4.9A)
 0.95A 5x2tI-4pcgA:
undetectable
5x2tJ-4pcgA:
undetectable
5x2tK-4pcgA:
undetectable
5x2tL-4pcgA:
undetectable		 5x2tI-4pcgA:
19.48
5x2tJ-4pcgA:
20.68
5x2tK-4pcgA:
19.48
5x2tL-4pcgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phq HEMOLYSIN E,
CHROMOSOMAL

(Escherichia
coli) 		PF06109
(HlyE) 		4 ALA A  16
THR A 257
THR A 260
ALA A 109
 None
 0.96A 5x2tI-4phqA:
undetectable
5x2tJ-4phqA:
undetectable
5x2tK-4phqA:
undetectable
5x2tL-4phqA:
undetectable		 5x2tI-4phqA:
19.52
5x2tJ-4phqA:
19.33
5x2tK-4phqA:
19.52
5x2tL-4phqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 5 ALA B 189
THR B 246
THR B 249
ALA B 214
TRP B 449
 None
 1.48A 5x2tI-4ritB:
undetectable
5x2tJ-4ritB:
undetectable
5x2tK-4ritB:
undetectable
5x2tL-4ritB:
undetectable		 5x2tI-4ritB:
16.78
5x2tJ-4ritB:
14.72
5x2tK-4ritB:
16.78
5x2tL-4ritB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		4 ALA A 432
THR A 436
THR A 439
ALA A 455
 None
 0.94A 5x2tI-4u3tA:
undetectable
5x2tJ-4u3tA:
undetectable
5x2tK-4u3tA:
undetectable
5x2tL-4u3tA:
undetectable		 5x2tI-4u3tA:
17.58
5x2tJ-4u3tA:
20.73
5x2tK-4u3tA:
17.58
5x2tL-4u3tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 ALA A 104
THR A 268
THR A 107
ALA A 223
 None
None
None
CAC  A 501 ( 3.9A)
 1.01A 5x2tI-4wb0A:
undetectable
5x2tJ-4wb0A:
undetectable
5x2tK-4wb0A:
undetectable
5x2tL-4wb0A:
undetectable		 5x2tI-4wb0A:
19.17
5x2tJ-4wb0A:
18.12
5x2tK-4wb0A:
19.17
5x2tL-4wb0A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt8 RV2671

(Mycobacterium
tuberculosis) 		PF01872
(RibD_C) 		4 ALA A 216
THR A 214
THR A 253
ALA A  43
 None
TMQ  A 302 (-4.0A)
None
None
 0.92A 5x2tI-4xt8A:
undetectable
5x2tJ-4xt8A:
undetectable
5x2tK-4xt8A:
undetectable
5x2tL-4xt8A:
undetectable		 5x2tI-4xt8A:
19.92
5x2tJ-4xt8A:
22.92
5x2tK-4xt8A:
19.92
5x2tL-4xt8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xu4 UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
vanbaalenii) 		no annotation 4 ALA A  85
THR A  89
THR A  92
ALA A 106
 BNG  A 304 ( 3.7A)
None
None
None
 0.74A 5x2tI-4xu4A:
undetectable
5x2tJ-4xu4A:
undetectable
5x2tK-4xu4A:
undetectable
5x2tL-4xu4A:
undetectable		 5x2tI-4xu4A:
20.95
5x2tJ-4xu4A:
24.19
5x2tK-4xu4A:
20.95
5x2tL-4xu4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 ALA A  91
THR A  95
THR A  98
TRP A 156
 None
None
None
NAD  A 501 (-4.3A)
 0.72A 5x2tI-4zwlA:
undetectable
5x2tJ-4zwlA:
undetectable
5x2tK-4zwlA:
undetectable
5x2tL-4zwlA:
undetectable		 5x2tI-4zwlA:
14.09
5x2tJ-4zwlA:
15.34
5x2tK-4zwlA:
14.09
5x2tL-4zwlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 THR A  95
THR A  98
ALA A 285
TRP A 156
 None
None
None
NAD  A 501 (-4.3A)
 0.89A 5x2tI-4zwlA:
undetectable
5x2tJ-4zwlA:
undetectable
5x2tK-4zwlA:
undetectable
5x2tL-4zwlA:
undetectable		 5x2tI-4zwlA:
14.09
5x2tJ-4zwlA:
15.34
5x2tK-4zwlA:
14.09
5x2tL-4zwlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 ALA A 334
THR A 332
THR A 330
ALA A 351
 None
 0.86A 5x2tI-5a42A:
undetectable
5x2tJ-5a42A:
undetectable
5x2tK-5a42A:
undetectable
5x2tL-5a42A:
undetectable		 5x2tI-5a42A:
6.48
5x2tJ-5a42A:
7.08
5x2tK-5a42A:
6.48
5x2tL-5a42A:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 4 ALA A 175
THR A 181
TRP A  41
ALA A 250
 None
 0.94A 5x2tI-5ah0A:
undetectable
5x2tJ-5ah0A:
undetectable
5x2tK-5ah0A:
undetectable
5x2tL-5ah0A:
undetectable		 5x2tI-5ah0A:
15.45
5x2tJ-5ah0A:
19.52
5x2tK-5ah0A:
15.45
5x2tL-5ah0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PRO A 365
ALA A 381
THR A 384
ALA A 185
 None
 0.98A 5x2tI-5ah4A:
undetectable
5x2tJ-5ah4A:
undetectable
5x2tK-5ah4A:
undetectable
5x2tL-5ah4A:
undetectable		 5x2tI-5ah4A:
16.75
5x2tJ-5ah4A:
20.23
5x2tK-5ah4A:
16.75
5x2tL-5ah4A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 PRO A 313
ALA A 377
TRP A 418
ALA A 163
 None
 0.89A 5x2tI-5aqaA:
undetectable
5x2tJ-5aqaA:
undetectable
5x2tK-5aqaA:
undetectable
5x2tL-5aqaA:
undetectable		 5x2tI-5aqaA:
17.23
5x2tJ-5aqaA:
18.62
5x2tK-5aqaA:
17.23
5x2tL-5aqaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5s ACETIC ACID

(Talaromyces
cellulolyticus) 		PF13472
(Lipase_GDSL_2) 		4 PRO A 183
THR A  12
THR A  15
ALA A 192
 None
 0.90A 5x2tI-5b5sA:
undetectable
5x2tJ-5b5sA:
undetectable
5x2tK-5b5sA:
undetectable
5x2tL-5b5sA:
undetectable		 5x2tI-5b5sA:
23.46
5x2tJ-5b5sA:
18.45
5x2tK-5b5sA:
23.46
5x2tL-5b5sA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE

(Thymus vulgaris) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ALA A 339
THR A 343
THR A 346
ALA A 305
 ALA  A 339 ( 0.0A)
THR  A 343 ( 0.8A)
THR  A 346 ( 0.8A)
ALA  A 305 ( 0.0A)
 0.99A 5x2tI-5c05A:
undetectable
5x2tJ-5c05A:
undetectable
5x2tK-5c05A:
undetectable
5x2tL-5c05A:
undetectable		 5x2tI-5c05A:
12.16
5x2tJ-5c05A:
13.06
5x2tK-5c05A:
12.16
5x2tL-5c05A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce5 TRIACYLGLYCEROL
LIPASE

(Geobacillus
thermocatenulatus) 		no annotation 4 ALA A 163
THR A 169
TRP A  31
ALA A 241
 None
P15  A 403 ( 4.4A)
None
None
 0.96A 5x2tI-5ce5A:
undetectable
5x2tJ-5ce5A:
undetectable
5x2tK-5ce5A:
undetectable
5x2tL-5ce5A:
undetectable		 5x2tI-5ce5A:
15.26
5x2tJ-5ce5A:
16.40
5x2tK-5ce5A:
15.26
5x2tL-5ce5A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1)
PF00604
(Flu_PB2) 		4 ALA B 282
THR B 286
THR B 289
ALA C 384
 None
 0.87A 5x2tI-5d9aB:
undetectable
5x2tJ-5d9aB:
4.0
5x2tK-5d9aB:
undetectable
5x2tL-5d9aB:
undetectable		 5x2tI-5d9aB:
11.32
5x2tJ-5d9aB:
10.99
5x2tK-5d9aB:
11.32
5x2tL-5d9aB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans) 		PF00344
(SecY) 		4 ALA Y 153
THR Y 157
THR Y 160
ALA Y  80
 None
 0.88A 5x2tI-5eulY:
undetectable
5x2tJ-5eulY:
undetectable
5x2tK-5eulY:
undetectable
5x2tL-5eulY:
undetectable		 5x2tI-5eulY:
17.20
5x2tJ-5eulY:
15.31
5x2tK-5eulY:
17.20
5x2tL-5eulY:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		4 ALA A 115
THR A 119
THR A 122
TRP A 180
 None
None
None
NAD  A 601 (-4.4A)
 0.81A 5x2tI-5fhzA:
undetectable
5x2tJ-5fhzA:
undetectable
5x2tK-5fhzA:
undetectable
5x2tL-5fhzA:
undetectable		 5x2tI-5fhzA:
13.72
5x2tJ-5fhzA:
13.91
5x2tK-5fhzA:
13.72
5x2tL-5fhzA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfn CEPHALOSPORIN-C
DEACETYLASE

(Thermotoga
maritima) 		PF05448
(AXE1) 		4 PRO A  16
ALA A 220
THR A 281
ALA A 259
 None
 0.99A 5x2tI-5hfnA:
undetectable
5x2tJ-5hfnA:
undetectable
5x2tK-5hfnA:
undetectable
5x2tL-5hfnA:
undetectable		 5x2tI-5hfnA:
18.97
5x2tJ-5hfnA:
18.41
5x2tK-5hfnA:
18.97
5x2tL-5hfnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i20 UNCHARACTERIZED
PROTEIN

(Starkeya
novella) 		PF00892
(EamA) 		4 PRO A 248
ALA A 125
THR A 132
ALA A  98
 None
None
None
OLC  A 301 ( 3.7A)
 0.95A 5x2tI-5i20A:
undetectable
5x2tJ-5i20A:
undetectable
5x2tK-5i20A:
undetectable
5x2tL-5i20A:
undetectable		 5x2tI-5i20A:
18.79
5x2tJ-5i20A:
21.67
5x2tK-5i20A:
18.79
5x2tL-5i20A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 ALA A 978
THR A 993
TRP A 984
ALA A1051
 None
 0.95A 5x2tI-5ikzA:
undetectable
5x2tJ-5ikzA:
undetectable
5x2tK-5ikzA:
undetectable
5x2tL-5ikzA:
undetectable		 5x2tI-5ikzA:
8.17
5x2tJ-5ikzA:
8.63
5x2tK-5ikzA:
8.17
5x2tL-5ikzA:
8.63