SIMILAR PATTERNS OF AMINO ACIDS FOR 5X24_A_LSNA503_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcw | CERULOPLASMIN (Homo sapiens) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PHE A1000PRO A1001GLY A1002THR A1003 | None | 0.54A | 5x24A-1kcwA:0.0 | 5x24A-1kcwA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lzk | HEROIN ESTERASE (Rhodococcus sp.) |
PF07859(Abhydrolase_3) | 4 | PHE A 285PRO A 286GLY A 287THR A 288 | None | 0.88A | 5x24A-1lzkA:0.0 | 5x24A-1lzkA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1md7 | C1R COMPLEMENTSERINE PROTEASE (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 4 | PRO A 459GLY A 456ASN A 457LYS A 454 | None | 0.89A | 5x24A-1md7A:undetectable | 5x24A-1md7A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhq | ADP-RIBOSYLATIONFACTOR BINDINGPROTEIN GGA2 (Homo sapiens) |
PF00790(VHS) | 4 | PHE A 97PRO A 60GLY A 59ASN A 58 | None | 0.96A | 5x24A-1mhqA:0.0 | 5x24A-1mhqA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mov | GFP-LIKENON-FLUORESCENTCHROMOPROTEIN (Montiporaefflorescens) |
PF01353(GFP) | 4 | PHE A 129PRO A 130GLY A 133ASN A 132 | NoneIOD A 302 ( 4.5A)NoneNone | 0.81A | 5x24A-1movA:0.0 | 5x24A-1movA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nne | DNA MISMATCH REPAIRPROTEIN MUTS (Thermusaquaticus) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 4 | PRO A 118GLY A 119THR A 120ASN A 132 | None | 1.00A | 5x24A-1nneA:0.0 | 5x24A-1nneA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nug | PROTEIN-GLUTAMINEGLUTAMYLTRANSFERASEE (Homo sapiens) |
PF00868(Transglut_N)PF00927(Transglut_C)PF01841(Transglut_core) | 4 | PHE A 275GLY A 277THR A 278ASN A 280 | None | 0.74A | 5x24A-1nugA:0.0 | 5x24A-1nugA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5o | URACILPHOSPHORIBOSYLTRANSFERASE (Thermotogamaritima) |
PF14681(UPRTase) | 4 | PHE A 29PRO A 26GLY A 25THR A 24 | NoneSO4 A 709 (-4.3A)SO4 A 709 (-3.4A)None | 0.93A | 5x24A-1o5oA:0.0 | 5x24A-1o5oA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oyj | GLUTATHIONES-TRANSFERASE (Oryza sativa) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | PHE A 80PRO A 81GLY A 82THR A 83 | None CL A 823 ( 4.1A) CL A 823 (-3.5A) CL A 823 ( 4.7A) | 0.41A | 5x24A-1oyjA:undetectable | 5x24A-1oyjA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3k | CREATININASE (Pseudomonasputida) |
PF02633(Creatininase) | 4 | PHE A 84PRO A 85GLY A 86THR A 87 | None | 0.73A | 5x24A-1q3kA:undetectable | 5x24A-1q3kA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qxy | METHIONYLAMINOPEPTIDASE (Staphylococcusaureus) |
PF00557(Peptidase_M24) | 4 | PRO A 139GLY A 140THR A 141LYS A 142 | None | 1.01A | 5x24A-1qxyA:undetectable | 5x24A-1qxyA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rvf | FAB 17-IA (Mus musculus) |
PF07686(V-set) | 4 | PHE L 14PRO L 15GLY L 16LYS L 18 | None | 0.84A | 5x24A-1rvfL:undetectable | 5x24A-1rvfL:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s8e | EXONUCLEASE PUTATIVE (Pyrococcusfuriosus) |
PF00149(Metallophos) | 4 | PRO A 58GLY A 59THR A 60LYS A 63 | None | 0.40A | 5x24A-1s8eA:undetectable | 5x24A-1s8eA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t61 | TYPE IV COLLAGEN (Bos taurus) |
PF01413(C4) | 4 | PRO A 22GLY A 23THR A 24LYS A 25 | None | 1.00A | 5x24A-1t61A:undetectable | 5x24A-1t61A:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uis | RED FLUORESCENTPROTEIN FP611 (Entacmaeaquadricolor) |
PF01353(GFP) | 4 | PHE A 126PRO A 127GLY A 130ASN A 129 | None | 0.89A | 5x24A-1uisA:undetectable | 5x24A-1uisA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | PRO A 471GLY A 470ASN A 467LYS A 468 | None | 0.96A | 5x24A-1v8bA:0.6 | 5x24A-1v8bA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9s | URACILPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF14681(UPRTase) | 4 | PHE A 28PRO A 25GLY A 24THR A 23 | None | 0.92A | 5x24A-1v9sA:undetectable | 5x24A-1v9sA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpv | UPF0230 PROTEINTM1468 (Thermotogamaritima) |
PF02645(DegV) | 4 | PRO A 274GLY A 275THR A 276ASN A 239 | None | 0.98A | 5x24A-1vpvA:undetectable | 5x24A-1vpvA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wd3 | ALPHA-L-ARABINOFURANOSIDASE B (Aspergilluskawachii) |
PF05270(AbfB)PF09206(ArabFuran-catal) | 4 | PRO A 142GLY A 143THR A 144ASN A 300 | None | 0.69A | 5x24A-1wd3A:undetectable | 5x24A-1wd3A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xed | POLYMERIC-IMMUNOGLOBULIN RECEPTOR (Homo sapiens) |
PF07686(V-set) | 4 | PHE A 69PRO A 70GLY A 73THR A 74 | None | 0.99A | 5x24A-1xedA:undetectable | 5x24A-1xedA:11.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yk4 | RUBREDOXIN (Pyrococcusabyssi) |
PF00301(Rubredoxin) | 4 | PRO A 26GLY A 27THR A 28LYS A 29 | None | 0.96A | 5x24A-1yk4A:undetectable | 5x24A-1yk4A:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azk | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sulfolobussolfataricus) |
PF00348(polyprenyl_synt) | 4 | PHE A 44GLY A 46THR A 47ASN A 49 | None | 0.64A | 5x24A-2azkA:0.0 | 5x24A-2azkA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btj | GREEN TO REDPHOTOCONVERTIBLEGPF-LIKE PROTEINEOSFP (Lobophylliahemprichii) |
PF01353(GFP) | 4 | PHE A 125PRO A 126GLY A 129ASN A 128 | None | 0.84A | 5x24A-2btjA:undetectable | 5x24A-2btjA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c9i | GREEN FLUORESCENTPROTEIN ASFP499 (Anemoniasulcata) |
PF01353(GFP) | 4 | PHE A 126PRO A 127GLY A 130ASN A 129 | None | 0.97A | 5x24A-2c9iA:undetectable | 5x24A-2c9iA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw1 | CATROCOLLASTATIN (Crotalus atrox) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 587GLY A 588THR A 589LYS A 590 | None | 0.98A | 5x24A-2dw1A:undetectable | 5x24A-2dw1A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7t | BASIC AGGLUTININ (Psophocarpustetragonolobus) |
PF00139(Lectin_legB) | 4 | PHE A 179PRO A 180GLY A 183THR A 184 | None | 0.99A | 5x24A-2e7tA:undetectable | 5x24A-2e7tA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ete | OXALATE OXIDASE 1 (Hordeum vulgare) |
PF00190(Cupin_1) | 4 | PRO A 65GLY A 66THR A 67ASN A 68 | None | 0.96A | 5x24A-2eteA:undetectable | 5x24A-2eteA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gi4 | POSSIBLEPHOSPHOTYROSINEPROTEIN PHOSPHATASE (Campylobacterjejuni) |
PF01451(LMWPc) | 4 | GLY A 54THR A 55ASN A 57LYS A 58 | None | 0.68A | 5x24A-2gi4A:undetectable | 5x24A-2gi4A:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw3 | KAEDE (Trachyphylliageoffroyi) |
PF01353(GFP) | 4 | PHE A 125PRO A 126GLY A 129ASN A 128 | None | 0.83A | 5x24A-2gw3A:undetectable | 5x24A-2gw3A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw4 | KAEDE (Trachyphylliageoffroyi) |
PF01353(GFP) | 4 | PHE B 125PRO B 126GLY B 129ASN B 128 | None | 0.82A | 5x24A-2gw4B:undetectable | 5x24A-2gw4B:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwm | 65 KDA VIRULENCEPROTEIN (Salmonellaenterica) |
PF03496(ADPrib_exo_Tox) | 4 | PHE A 541PRO A 542THR A 545ASN A 544 | None | 0.97A | 5x24A-2gwmA:undetectable | 5x24A-2gwmA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2icu | HYPOTHETICAL PROTEINYEDK (Escherichiacoli) |
PF02586(SRAP) | 4 | PRO A 47GLY A 48THR A 49LYS A 50 | None | 1.00A | 5x24A-2icuA:undetectable | 5x24A-2icuA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jh1 | MICRONEMAL PROTEIN 1 (Toxoplasmagondii) |
PF10564(MAR_sialic_bdg) | 4 | PHE A 142PRO A 143GLY A 144THR A 145 | NoneNoneACT A1257 ( 3.9A)None | 0.72A | 5x24A-2jh1A:undetectable | 5x24A-2jh1A:19.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 6 | PHE A 226PRO A 227GLY A 228THR A 229ASN A 231LYS A 232 | PLM A 502 (-3.9A)NoneNonePLM A 502 (-3.9A)NoneNone | 0.74A | 5x24A-2nnjA:57.6 | 5x24A-2nnjA:78.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nr7 | SECRETION ACTIVATORPROTEIN, PUTATIVE (Porphyromonasgingivalis) |
PF05838(Glyco_hydro_108)PF09374(PG_binding_3) | 4 | GLY A 119THR A 122ASN A 120LYS A 121 | None | 0.96A | 5x24A-2nr7A:1.7 | 5x24A-2nr7A:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ov9 | HYPOTHETICAL PROTEIN (Rhodococcusjostii) |
PF03061(4HBT) | 4 | PRO A 94GLY A 93THR A 92ASN A 96 | None | 1.01A | 5x24A-2ov9A:undetectable | 5x24A-2ov9A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vzx | GREEN FLUORESCENTPROTEIN (Dendronephthyasp. SSAL-2002) |
PF01353(GFP) | 4 | PHE A 125PRO A 126GLY A 129ASN A 128 | None | 0.90A | 5x24A-2vzxA:undetectable | 5x24A-2vzxA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wya | HYDROXYMETHYLGLUTARYL-COA SYNTHASE,MITOCHONDRIAL (Homo sapiens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | PHE A 486PRO A 487GLY A 488THR A 489 | None | 0.64A | 5x24A-2wyaA:undetectable | 5x24A-2wyaA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xly | CLOQ (Streptomycesroseochromogenus) |
PF11468(PTase_Orf2) | 4 | PHE A 10GLY A 286THR A 285ASN A 287 | None | 0.96A | 5x24A-2xlyA:undetectable | 5x24A-2xlyA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zws | NEUTRAL CERAMIDASE (Pseudomonasaeruginosa) |
PF04734(Ceramidase_alk)PF17048(Ceramidse_alk_C) | 4 | PRO A 387GLY A 381THR A 380ASN A 382 | None | 0.90A | 5x24A-2zwsA:undetectable | 5x24A-2zwsA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3adf | MONOMERIC AZAMIGREEN (Galaxeafascicularis) |
PF01353(GFP) | 4 | PHE A 125PRO A 126GLY A 129ASN A 128 | None | 0.88A | 5x24A-3adfA:undetectable | 5x24A-3adfA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayr | ENDOGLUCANASE (Piromycesrhizinflatus) |
PF00150(Cellulase) | 4 | PHE A 104GLY A 102ASN A 101LYS A 100 | None | 0.97A | 5x24A-3ayrA:undetectable | 5x24A-3ayrA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3u | 4-HYDROXYBUTYRATECOA-TRANSFERASE (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 4 | PRO A 24GLY A 25THR A 26ASN A 53 | None | 0.98A | 5x24A-3d3uA:undetectable | 5x24A-3d3uA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dsl | ZINCMETALLOPROTEINASE-DISINTEGRINBOTHROPASIN (Bothropsjararaca) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 399GLY A 400THR A 401LYS A 402 | None | 0.92A | 5x24A-3dslA:undetectable | 5x24A-3dslA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3frk | QDTB (Thermoanaerobacteriumthermosaccharolyticum) |
PF01041(DegT_DnrJ_EryC1) | 4 | PRO A 331GLY A 328THR A 327ASN A 329 | None | 0.95A | 5x24A-3frkA:undetectable | 5x24A-3frkA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyr | PHENOXAZINONESYNTHASE (Streptomycesantibioticus) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PRO A 448GLY A 449THR A 450LYS A 451 | None | 0.99A | 5x24A-3gyrA:undetectable | 5x24A-3gyrA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzd | SELENOCYSTEINE LYASE (Homo sapiens) |
PF00266(Aminotran_5) | 4 | PHE C 349PRO C 350GLY C 351THR C 352 | None | 0.68A | 5x24A-3gzdC:undetectable | 5x24A-3gzdC:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hm7 | ALLANTOINASE (Bacillushalodurans) |
PF01979(Amidohydro_1) | 4 | PHE A 56PRO A 57GLY A 58THR A 391 | None | 0.89A | 5x24A-3hm7A:undetectable | 5x24A-3hm7A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hq9 | CYTOCHROME C551PEROXIDASE (Geobactersulfurreducens) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 4 | PHE A 162PRO A 163GLY A 164LYS A 166 | None | 0.98A | 5x24A-3hq9A:undetectable | 5x24A-3hq9A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF02738(Ald_Xan_dh_C2) | 4 | PHE B 40GLY B 94THR B 93ASN B 95 | None | 0.83A | 5x24A-3hrdB:undetectable | 5x24A-3hrdB:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hum | PENICILLIN-BINDINGPROTEIN 4 (Staphylococcusaureus) |
PF00768(Peptidase_S11)PF09211(DUF1958) | 4 | PHE A 241GLY A 261THR A 260ASN A 269 | CEW A 501 (-4.1A)CEW A 501 (-3.1A)CEW A 501 ( 4.3A)None | 1.01A | 5x24A-3humA:undetectable | 5x24A-3humA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i23 | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Enterococcusfaecalis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | GLY A 315THR A 311ASN A 314LYS A 313 | None | 0.88A | 5x24A-3i23A:undetectable | 5x24A-3i23A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icu | E3 UBIQUITIN-PROTEINLIGASE RNF128 (Homo sapiens) |
PF02225(PA) | 4 | PHE A 148PRO A 149GLY A 150THR A 151 | None | 0.85A | 5x24A-3icuA:undetectable | 5x24A-3icuA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7l | ATRAGIN (Naja atra) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 591GLY A 592THR A 593LYS A 594 | None | 0.98A | 5x24A-3k7lA:undetectable | 5x24A-3k7lA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2e | GLYCOCYAMINE KINASEALPHA CHAIN (Namalycastissp. ST01) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 4 | GLY A 85THR A 84ASN A 39LYS A 83 | None | 0.89A | 5x24A-3l2eA:undetectable | 5x24A-3l2eA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mux | PUTATIVE4-HYDROXY-2-OXOGLUTARATE ALDOLASE (Bacillusanthracis) |
PF07071(KDGP_aldolase) | 4 | PHE A 97GLY A 132THR A 131ASN A 75 | None | 0.92A | 5x24A-3muxA:undetectable | 5x24A-3muxA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no4 | CREATININEAMIDOHYDROLASE (Nostocpunctiforme) |
PF02633(Creatininase) | 4 | PHE A 74PRO A 75GLY A 76THR A 77 | None | 0.70A | 5x24A-3no4A:undetectable | 5x24A-3no4A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwo | PROLINEIMINOPEPTIDASE (Mycolicibacteriumsmegmatis) |
PF00561(Abhydrolase_1) | 4 | PHE A 275PRO A 276GLY A 277THR A 278 | None | 0.63A | 5x24A-3nwoA:undetectable | 5x24A-3nwoA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfh | EPIDERMIN LEADERPEPTIDE PROCESSINGSERINE PROTEASE EPIP (Staphylococcusaureus) |
PF00082(Peptidase_S8) | 4 | PHE A 167GLY A 169THR A 170ASN A 165 | None | 0.75A | 5x24A-3qfhA:undetectable | 5x24A-3qfhA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rag | UNCHARACTERIZEDPROTEIN (Alicyclobacillusacidocaldarius) |
PF00092(VWA) | 4 | PHE A 176PRO A 177GLY A 178THR A 184 | None | 0.97A | 5x24A-3ragA:undetectable | 5x24A-3ragA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0w | IMMUNOGLOBULINVARIABLE LAMBDADOMAIN (Homo sapiens) |
PF07686(V-set) | 4 | PHE A 39PRO A 40GLY A 41THR A 42 | None | 0.86A | 5x24A-3t0wA:undetectable | 5x24A-3t0wA:11.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tej | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00550(PP-binding)PF00975(Thioesterase) | 4 | PRO A1277GLY A1278THR A1279LYS A1282 | None | 0.91A | 5x24A-3tejA:undetectable | 5x24A-3tejA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0k | RCAMP (Entacmaeaquadricolor) |
PF01353(GFP)PF13499(EF-hand_7) | 4 | PHE A 277PRO A 278GLY A 281ASN A 280 | None | 0.92A | 5x24A-3u0kA:undetectable | 5x24A-3u0kA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uaq | LBPB B-LOBE (Moraxella bovis) |
PF01298(TbpB_B_D)PF17484(TbpB_A) | 4 | PHE A 313GLY A 315THR A 163ASN A 161 | None | 0.89A | 5x24A-3uaqA:undetectable | 5x24A-3uaqA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut2 | CATALASE-PEROXIDASE2 (Magnaportheoryzae) |
PF00141(peroxidase) | 4 | PHE A 135GLY A 202THR A 201ASN A 203 | None | 0.80A | 5x24A-3ut2A:undetectable | 5x24A-3ut2A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3a | V-TYPE ATP SYNTHASEALPHA CHAIN (Thermusthermophilus) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 4 | PHE A 141GLY A 278THR A 277LYS A 276 | None | 1.01A | 5x24A-3w3aA:undetectable | 5x24A-3w3aA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuy | NITRILASE (Synechocystissp. PCC 6803) |
PF00795(CN_hydrolase) | 4 | PHE A 193PRO A 194GLY A 195THR A 225 | None | 0.89A | 5x24A-3wuyA:undetectable | 5x24A-3wuyA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhh | NUCLEOPROTEIN (Californiaencephalitisorthobunyavirus) |
PF00952(Bunya_nucleocap) | 4 | PHE B 146PRO B 147GLY B 148THR B 149 | None | 0.84A | 5x24A-4bhhB:undetectable | 5x24A-4bhhB:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4epp | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Tetrahymenathermophila) |
PF05028(PARG_cat) | 4 | PHE A 230PRO A 231GLY A 232THR A 233 | None | 0.63A | 5x24A-4eppA:undetectable | 5x24A-4eppA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gf2 | ERYTHROCYTE BINDINGANTIGEN 140 (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 4 | PHE A 476PRO A 477GLY A 478THR A 479 | None | 0.52A | 5x24A-4gf2A:undetectable | 5x24A-4gf2A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0o | PROTEIN ELYS (Mus musculus) |
PF16687(ELYS-bb) | 4 | PHE A 38GLY A 44ASN A 43LYS A 42 | None | 0.80A | 5x24A-4i0oA:undetectable | 5x24A-4i0oA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwn | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 4 | PRO A 56GLY A 57THR A 58ASN A 82 | None | 1.00A | 5x24A-4iwnA:undetectable | 5x24A-4iwnA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jj9 | 5-CARBOXYMETHYL-2-HYDROXYMUCONATEDELTA-ISOMERASE (Bordetellabronchiseptica) |
PF02962(CHMI) | 4 | PHE A 41PRO A 42GLY A 45THR A 46 | None | 0.83A | 5x24A-4jj9A:undetectable | 5x24A-4jj9A:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4js5 | EXODEOXYRIBONUCLEASEI (Escherichiacoli) |
PF00929(RNase_T)PF08411(Exonuc_X-T_C) | 4 | PHE A 415PRO A 416GLY A 417THR A 418 | None | 0.48A | 5x24A-4js5A:undetectable | 5x24A-4js5A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kgb | SUCCINYL-COA:3-KETOACID-COENZYME ATRANSFERASE (Drosophilamelanogaster) |
PF01144(CoA_trans) | 4 | PRO A 429GLY A 430THR A 431LYS A 432 | None | 1.01A | 5x24A-4kgbA:undetectable | 5x24A-4kgbA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfy | DIHYDROOROTASE (Burkholderiacenocepacia) |
PF01979(Amidohydro_1) | 4 | PHE A 183PRO A 184GLY A 185LYS A 187 | NoneNoneNoneEDO A 403 (-2.8A) | 0.97A | 5x24A-4lfyA:undetectable | 5x24A-4lfyA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ohs | FAR-RED FLUORESCENTPROTEIN AQ143 (Actinia equina) |
PF01353(GFP) | 4 | PHE A 126PRO A 127GLY A 130ASN A 129 | None | 0.87A | 5x24A-4ohsA:undetectable | 5x24A-4ohsA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oy2 | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 1 (Saccharomycescerevisiae) |
PF12157(DUF3591) | 4 | PRO A 504GLY A 505THR A 506LYS A 507 | None | 0.95A | 5x24A-4oy2A:undetectable | 5x24A-4oy2A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oy4 | CHIMERA PROTEIN OFCALMODULIN, GPF-LIKEPROTEIN EOSFP, ANDMYOSIN LIGHT CHAINKINASE (Gallus gallus;Lobophylliahemprichii;Rattusnorvegicus) |
PF01353(GFP)PF13499(EF-hand_7) | 4 | PHE A 365PRO A 366GLY A 369ASN A 368 | None | 0.79A | 5x24A-4oy4A:undetectable | 5x24A-4oy4A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjk | ACETOLACTATESYNTHASE (Bacillussubtilis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | PHE A 132PRO A 134THR A 136LYS A 137 | None | 0.99A | 5x24A-4rjkA:undetectable | 5x24A-4rjkA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tza | FLUORESCENT PROTEIN (syntheticconstruct) |
no annotation | 4 | PHE C 125PRO C 126GLY C 129ASN C 128 | None | 0.82A | 5x24A-4tzaC:undetectable | 5x24A-4tzaC:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud1 | N PROTEIN (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
PF00937(Corona_nucleoca) | 4 | PRO A 152GLY A 153THR A 154LYS A 155 | None | 1.02A | 5x24A-4ud1A:undetectable | 5x24A-4ud1A:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d4k | POLYMERICIMMUNOGLOBULINRECEPTOR (Homo sapiens) |
PF07686(V-set) | 4 | PHE A 69PRO A 70GLY A 73THR A 74 | NAG A 602 ( 2.9A)NoneNoneNAG A 602 ( 4.2A) | 0.94A | 5x24A-5d4kA:undetectable | 5x24A-5d4kA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej1 | PUTATIVE CELLULOSESYNTHASE (Rhodobactersphaeroides) |
PF00535(Glycos_transf_2)PF03552(Cellulose_synt)PF07238(PilZ) | 4 | PHE A 598PRO A 596GLY A 599ASN A 600 | None | 1.01A | 5x24A-5ej1A:undetectable | 5x24A-5ej1A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijl | DNA POLYMERASE IILARGE SUBUNIT (Pyrococcusabyssi) |
PF03833(PolC_DP2) | 4 | PHE A 816GLY A 819THR A 820ASN A 971 | None | 0.95A | 5x24A-5ijlA:undetectable | 5x24A-5ijlA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwz | CELLULOSE-BINDINGFAMILY II (Streptomycessp. SirexAA-E) |
PF02012(BNR) | 4 | PRO A 486GLY A 487THR A 488ASN A 507 | None | 0.93A | 5x24A-5jwzA:undetectable | 5x24A-5jwzA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kp7 | CURD (Mooreaproducens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | PHE A 391PRO A 392GLY A 393LYS A 397 | None | 0.76A | 5x24A-5kp7A:0.0 | 5x24A-5kp7A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9o | DEOXYFRUCTOSYL-AMINOACID TRANSPORTERPERIPLASMIC BINDINGPROTEIN (Agrobacteriumfabrum) |
PF00497(SBP_bac_3) | 4 | PHE A 264PRO A 265GLY A 266THR A 267 | NoneNoneNoneEDO A 306 (-4.6A) | 0.89A | 5x24A-5l9oA:undetectable | 5x24A-5l9oA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 4 | PHE A 994PRO A 995GLY A 996THR A 997 | None | 0.57A | 5x24A-5n4lA:undetectable | 5x24A-5n4lA:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opt | 40S RIBOSOMALPROTEIN SA (Trypanosomacruzi) |
no annotation | 4 | PHE f 111GLY f 109THR f 110ASN f 113 | None A E1789 ( 3.9A)None U E1761 ( 2.8A) | 0.92A | 5x24A-5optf:undetectable | 5x24A-5optf:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM IREACTION CENTERSUBUNIT PSAK 2 (Synechocystissp. PCC 6803) |
no annotation | 4 | PHE k 61GLY k 45THR k 44LYS k 43 | None | 0.75A | 5x24A-5oy0k:undetectable | 5x24A-5oy0k:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t2u | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 4 | PHE A 141PRO A 142GLY A 143THR A 144 | None | 0.64A | 5x24A-5t2uA:undetectable | 5x24A-5t2uA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ukg | K-GECO (Entacmaeaquadricolor) |
no annotation | 4 | PHE A 248PRO A 249GLY A 252ASN A 251 | None | 0.95A | 5x24A-5ukgA:undetectable | 5x24A-5ukgA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0m | TERMINALURIDYLYLTRANSFERASE7 (Homo sapiens) |
PF00098(zf-CCHC)PF03828(PAP_assoc) | 5 | PHE A1037PRO A1038GLY A1039THR A1040LYS A1041 | None | 0.95A | 5x24A-5w0mA:undetectable | 5x24A-5w0mA:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoz | TRYPSIN PROTEININHIBITOR 2 (Cicer arietinum) |
no annotation | 4 | PHE A 83GLY A 85THR A 86ASN A 136 | None | 0.51A | 5x24A-5xozA:undetectable | 5x24A-5xozA:12.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 6 | PHE A 226PRO A 227GLY A 228THR A 229ASN A 231LYS A 232 | LSN A 502 (-4.7A)LSN A 502 (-3.7A)LSN A 502 (-3.4A)LSN A 502 (-3.9A)LSN A 502 (-4.3A)LSN A 502 (-2.9A) | 0.39A | 5x24A-5xxiA:62.5 | 5x24A-5xxiA:99.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yax | SCFV1 ANTIBODY (Homo sapiens) |
no annotation | 4 | PHE A1045PRO A1046GLY A1047THR A1048 | None | 0.75A | 5x24A-5yaxA:undetectable | 5x24A-5yaxA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z4g | SAHS4 (Ramazzottiusvarieornatus) |
no annotation | 4 | PHE A 90PRO A 91GLY A 92THR A 93 | None | 0.70A | 5x24A-5z4gA:undetectable | 5x24A-5z4gA:12.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az1 | RIBOSOMAL PROTEIN S2 (Leishmaniadonovani) |
no annotation | 4 | PHE B 111GLY B 109THR B 110ASN B 113 | None A 11673 ( 3.9A)None U 11645 ( 3.2A) | 0.90A | 5x24A-6az1B:undetectable | 5x24A-6az1B:9.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b0k | IOTA-CARRAGEENANSULFATASE (Pseudoalteromonas) |
no annotation | 4 | PHE A 323GLY A 65THR A 66LYS A 333 | None | 0.98A | 5x24A-6b0kA:undetectable | 5x24A-6b0kA:11.06 |