SIMILAR PATTERNS OF AMINO ACIDS FOR 5X24_A_LSNA503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 PHE A1000
PRO A1001
GLY A1002
THR A1003
None
0.54A 5x24A-1kcwA:
0.0
5x24A-1kcwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.)
PF07859
(Abhydrolase_3)
4 PHE A 285
PRO A 286
GLY A 287
THR A 288
None
0.88A 5x24A-1lzkA:
0.0
5x24A-1lzkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
4 PRO A 459
GLY A 456
ASN A 457
LYS A 454
None
0.89A 5x24A-1md7A:
undetectable
5x24A-1md7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2


(Homo sapiens)
PF00790
(VHS)
4 PHE A  97
PRO A  60
GLY A  59
ASN A  58
None
0.96A 5x24A-1mhqA:
0.0
5x24A-1mhqA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mov GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN


(Montipora
efflorescens)
PF01353
(GFP)
4 PHE A 129
PRO A 130
GLY A 133
ASN A 132
None
IOD  A 302 ( 4.5A)
None
None
0.81A 5x24A-1movA:
0.0
5x24A-1movA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS


(Thermus
aquaticus)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
4 PRO A 118
GLY A 119
THR A 120
ASN A 132
None
1.00A 5x24A-1nneA:
0.0
5x24A-1nneA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E


(Homo sapiens)
PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core)
4 PHE A 275
GLY A 277
THR A 278
ASN A 280
None
0.74A 5x24A-1nugA:
0.0
5x24A-1nugA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermotoga
maritima)
PF14681
(UPRTase)
4 PHE A  29
PRO A  26
GLY A  25
THR A  24
None
SO4  A 709 (-4.3A)
SO4  A 709 (-3.4A)
None
0.93A 5x24A-1o5oA:
0.0
5x24A-1o5oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyj GLUTATHIONE
S-TRANSFERASE


(Oryza sativa)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
4 PHE A  80
PRO A  81
GLY A  82
THR A  83
None
CL  A 823 ( 4.1A)
CL  A 823 (-3.5A)
CL  A 823 ( 4.7A)
0.41A 5x24A-1oyjA:
undetectable
5x24A-1oyjA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida)
PF02633
(Creatininase)
4 PHE A  84
PRO A  85
GLY A  86
THR A  87
None
0.73A 5x24A-1q3kA:
undetectable
5x24A-1q3kA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE


(Staphylococcus
aureus)
PF00557
(Peptidase_M24)
4 PRO A 139
GLY A 140
THR A 141
LYS A 142
None
1.01A 5x24A-1qxyA:
undetectable
5x24A-1qxyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA

(Mus musculus)
PF07686
(V-set)
4 PHE L  14
PRO L  15
GLY L  16
LYS L  18
None
0.84A 5x24A-1rvfL:
undetectable
5x24A-1rvfL:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus)
PF00149
(Metallophos)
4 PRO A  58
GLY A  59
THR A  60
LYS A  63
None
0.40A 5x24A-1s8eA:
undetectable
5x24A-1s8eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus)
PF01413
(C4)
4 PRO A  22
GLY A  23
THR A  24
LYS A  25
None
1.00A 5x24A-1t61A:
undetectable
5x24A-1t61A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uis RED FLUORESCENT
PROTEIN FP611


(Entacmaea
quadricolor)
PF01353
(GFP)
4 PHE A 126
PRO A 127
GLY A 130
ASN A 129
None
0.89A 5x24A-1uisA:
undetectable
5x24A-1uisA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE


(Plasmodium
falciparum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 PRO A 471
GLY A 470
ASN A 467
LYS A 468
None
0.96A 5x24A-1v8bA:
0.6
5x24A-1v8bA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermus
thermophilus)
PF14681
(UPRTase)
4 PHE A  28
PRO A  25
GLY A  24
THR A  23
None
0.92A 5x24A-1v9sA:
undetectable
5x24A-1v9sA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpv UPF0230 PROTEIN
TM1468


(Thermotoga
maritima)
PF02645
(DegV)
4 PRO A 274
GLY A 275
THR A 276
ASN A 239
None
0.98A 5x24A-1vpvA:
undetectable
5x24A-1vpvA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B


(Aspergillus
kawachii)
PF05270
(AbfB)
PF09206
(ArabFuran-catal)
4 PRO A 142
GLY A 143
THR A 144
ASN A 300
None
0.69A 5x24A-1wd3A:
undetectable
5x24A-1wd3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xed POLYMERIC-IMMUNOGLOB
ULIN RECEPTOR


(Homo sapiens)
PF07686
(V-set)
4 PHE A  69
PRO A  70
GLY A  73
THR A  74
None
0.99A 5x24A-1xedA:
undetectable
5x24A-1xedA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk4 RUBREDOXIN

(Pyrococcus
abyssi)
PF00301
(Rubredoxin)
4 PRO A  26
GLY A  27
THR A  28
LYS A  29
None
0.96A 5x24A-1yk4A:
undetectable
5x24A-1yk4A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
4 PHE A  44
GLY A  46
THR A  47
ASN A  49
None
0.64A 5x24A-2azkA:
0.0
5x24A-2azkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP


(Lobophyllia
hemprichii)
PF01353
(GFP)
4 PHE A 125
PRO A 126
GLY A 129
ASN A 128
None
0.84A 5x24A-2btjA:
undetectable
5x24A-2btjA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9i GREEN FLUORESCENT
PROTEIN ASFP499


(Anemonia
sulcata)
PF01353
(GFP)
4 PHE A 126
PRO A 127
GLY A 130
ASN A 129
None
0.97A 5x24A-2c9iA:
undetectable
5x24A-2c9iA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 587
GLY A 588
THR A 589
LYS A 590
None
0.98A 5x24A-2dw1A:
undetectable
5x24A-2dw1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7t BASIC AGGLUTININ

(Psophocarpus
tetragonolobus)
PF00139
(Lectin_legB)
4 PHE A 179
PRO A 180
GLY A 183
THR A 184
None
0.99A 5x24A-2e7tA:
undetectable
5x24A-2e7tA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ete OXALATE OXIDASE 1

(Hordeum vulgare)
PF00190
(Cupin_1)
4 PRO A  65
GLY A  66
THR A  67
ASN A  68
None
0.96A 5x24A-2eteA:
undetectable
5x24A-2eteA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gi4 POSSIBLE
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE


(Campylobacter
jejuni)
PF01451
(LMWPc)
4 GLY A  54
THR A  55
ASN A  57
LYS A  58
None
0.68A 5x24A-2gi4A:
undetectable
5x24A-2gi4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi)
PF01353
(GFP)
4 PHE A 125
PRO A 126
GLY A 129
ASN A 128
None
0.83A 5x24A-2gw3A:
undetectable
5x24A-2gw3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE

(Trachyphyllia
geoffroyi)
PF01353
(GFP)
4 PHE B 125
PRO B 126
GLY B 129
ASN B 128
None
0.82A 5x24A-2gw4B:
undetectable
5x24A-2gw4B:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwm 65 KDA VIRULENCE
PROTEIN


(Salmonella
enterica)
PF03496
(ADPrib_exo_Tox)
4 PHE A 541
PRO A 542
THR A 545
ASN A 544
None
0.97A 5x24A-2gwmA:
undetectable
5x24A-2gwmA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK


(Escherichia
coli)
PF02586
(SRAP)
4 PRO A  47
GLY A  48
THR A  49
LYS A  50
None
1.00A 5x24A-2icuA:
undetectable
5x24A-2icuA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh1 MICRONEMAL PROTEIN 1

(Toxoplasma
gondii)
PF10564
(MAR_sialic_bdg)
4 PHE A 142
PRO A 143
GLY A 144
THR A 145
None
None
ACT  A1257 ( 3.9A)
None
0.72A 5x24A-2jh1A:
undetectable
5x24A-2jh1A:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
6 PHE A 226
PRO A 227
GLY A 228
THR A 229
ASN A 231
LYS A 232
PLM  A 502 (-3.9A)
None
None
PLM  A 502 (-3.9A)
None
None
0.74A 5x24A-2nnjA:
57.6
5x24A-2nnjA:
78.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr7 SECRETION ACTIVATOR
PROTEIN, PUTATIVE


(Porphyromonas
gingivalis)
PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3)
4 GLY A 119
THR A 122
ASN A 120
LYS A 121
None
0.96A 5x24A-2nr7A:
1.7
5x24A-2nr7A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii)
PF03061
(4HBT)
4 PRO A  94
GLY A  93
THR A  92
ASN A  96
None
1.01A 5x24A-2ov9A:
undetectable
5x24A-2ov9A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzx GREEN FLUORESCENT
PROTEIN


(Dendronephthya
sp. SSAL-2002)
PF01353
(GFP)
4 PHE A 125
PRO A 126
GLY A 129
ASN A 128
None
0.90A 5x24A-2vzxA:
undetectable
5x24A-2vzxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL


(Homo sapiens)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
4 PHE A 486
PRO A 487
GLY A 488
THR A 489
None
0.64A 5x24A-2wyaA:
undetectable
5x24A-2wyaA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus)
PF11468
(PTase_Orf2)
4 PHE A  10
GLY A 286
THR A 285
ASN A 287
None
0.96A 5x24A-2xlyA:
undetectable
5x24A-2xlyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa)
PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C)
4 PRO A 387
GLY A 381
THR A 380
ASN A 382
None
0.90A 5x24A-2zwsA:
undetectable
5x24A-2zwsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN


(Galaxea
fascicularis)
PF01353
(GFP)
4 PHE A 125
PRO A 126
GLY A 129
ASN A 128
None
0.88A 5x24A-3adfA:
undetectable
5x24A-3adfA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus)
PF00150
(Cellulase)
4 PHE A 104
GLY A 102
ASN A 101
LYS A 100
None
0.97A 5x24A-3ayrA:
undetectable
5x24A-3ayrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 PRO A  24
GLY A  25
THR A  26
ASN A  53
None
0.98A 5x24A-3d3uA:
undetectable
5x24A-3d3uA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN


(Bothrops
jararaca)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 399
GLY A 400
THR A 401
LYS A 402
None
0.92A 5x24A-3dslA:
undetectable
5x24A-3dslA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frk QDTB

(Thermoanaerobacterium
thermosaccharolyticum)
PF01041
(DegT_DnrJ_EryC1)
4 PRO A 331
GLY A 328
THR A 327
ASN A 329
None
0.95A 5x24A-3frkA:
undetectable
5x24A-3frkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE


(Streptomyces
antibioticus)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 PRO A 448
GLY A 449
THR A 450
LYS A 451
None
0.99A 5x24A-3gyrA:
undetectable
5x24A-3gyrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens)
PF00266
(Aminotran_5)
4 PHE C 349
PRO C 350
GLY C 351
THR C 352
None
0.68A 5x24A-3gzdC:
undetectable
5x24A-3gzdC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans)
PF01979
(Amidohydro_1)
4 PHE A  56
PRO A  57
GLY A  58
THR A 391
None
0.89A 5x24A-3hm7A:
undetectable
5x24A-3hm7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE


(Geobacter
sulfurreducens)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
4 PHE A 162
PRO A 163
GLY A 164
LYS A 166
None
0.98A 5x24A-3hq9A:
undetectable
5x24A-3hq9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT


(Eubacterium
barkeri)
PF02738
(Ald_Xan_dh_C2)
4 PHE B  40
GLY B  94
THR B  93
ASN B  95
None
0.83A 5x24A-3hrdB:
undetectable
5x24A-3hrdB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4


(Staphylococcus
aureus)
PF00768
(Peptidase_S11)
PF09211
(DUF1958)
4 PHE A 241
GLY A 261
THR A 260
ASN A 269
CEW  A 501 (-4.1A)
CEW  A 501 (-3.1A)
CEW  A 501 ( 4.3A)
None
1.01A 5x24A-3humA:
undetectable
5x24A-3humA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Enterococcus
faecalis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLY A 315
THR A 311
ASN A 314
LYS A 313
None
0.88A 5x24A-3i23A:
undetectable
5x24A-3i23A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128


(Homo sapiens)
PF02225
(PA)
4 PHE A 148
PRO A 149
GLY A 150
THR A 151
None
0.85A 5x24A-3icuA:
undetectable
5x24A-3icuA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7l ATRAGIN

(Naja atra)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 591
GLY A 592
THR A 593
LYS A 594
None
0.98A 5x24A-3k7lA:
undetectable
5x24A-3k7lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN


(Namalycastis
sp. ST01)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
4 GLY A  85
THR A  84
ASN A  39
LYS A  83
None
0.89A 5x24A-3l2eA:
undetectable
5x24A-3l2eA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE


(Bacillus
anthracis)
PF07071
(KDGP_aldolase)
4 PHE A  97
GLY A 132
THR A 131
ASN A  75
None
0.92A 5x24A-3muxA:
undetectable
5x24A-3muxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no4 CREATININE
AMIDOHYDROLASE


(Nostoc
punctiforme)
PF02633
(Creatininase)
4 PHE A  74
PRO A  75
GLY A  76
THR A  77
None
0.70A 5x24A-3no4A:
undetectable
5x24A-3no4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE


(Mycolicibacterium
smegmatis)
PF00561
(Abhydrolase_1)
4 PHE A 275
PRO A 276
GLY A 277
THR A 278
None
0.63A 5x24A-3nwoA:
undetectable
5x24A-3nwoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP


(Staphylococcus
aureus)
PF00082
(Peptidase_S8)
4 PHE A 167
GLY A 169
THR A 170
ASN A 165
None
0.75A 5x24A-3qfhA:
undetectable
5x24A-3qfhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF00092
(VWA)
4 PHE A 176
PRO A 177
GLY A 178
THR A 184
None
0.97A 5x24A-3ragA:
undetectable
5x24A-3ragA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0w IMMUNOGLOBULIN
VARIABLE LAMBDA
DOMAIN


(Homo sapiens)
PF07686
(V-set)
4 PHE A  39
PRO A  40
GLY A  41
THR A  42
None
0.86A 5x24A-3t0wA:
undetectable
5x24A-3t0wA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tej ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00550
(PP-binding)
PF00975
(Thioesterase)
4 PRO A1277
GLY A1278
THR A1279
LYS A1282
None
0.91A 5x24A-3tejA:
undetectable
5x24A-3tejA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor)
PF01353
(GFP)
PF13499
(EF-hand_7)
4 PHE A 277
PRO A 278
GLY A 281
ASN A 280
None
0.92A 5x24A-3u0kA:
undetectable
5x24A-3u0kA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis)
PF01298
(TbpB_B_D)
PF17484
(TbpB_A)
4 PHE A 313
GLY A 315
THR A 163
ASN A 161
None
0.89A 5x24A-3uaqA:
undetectable
5x24A-3uaqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2


(Magnaporthe
oryzae)
PF00141
(peroxidase)
4 PHE A 135
GLY A 202
THR A 201
ASN A 203
None
0.80A 5x24A-3ut2A:
undetectable
5x24A-3ut2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN


(Thermus
thermophilus)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
4 PHE A 141
GLY A 278
THR A 277
LYS A 276
None
1.01A 5x24A-3w3aA:
undetectable
5x24A-3w3aA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuy NITRILASE

(Synechocystis
sp. PCC 6803)
PF00795
(CN_hydrolase)
4 PHE A 193
PRO A 194
GLY A 195
THR A 225
None
0.89A 5x24A-3wuyA:
undetectable
5x24A-3wuyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhh NUCLEOPROTEIN

(California
encephalitis
orthobunyavirus)
PF00952
(Bunya_nucleocap)
4 PHE B 146
PRO B 147
GLY B 148
THR B 149
None
0.84A 5x24A-4bhhB:
undetectable
5x24A-4bhhB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE


(Tetrahymena
thermophila)
PF05028
(PARG_cat)
4 PHE A 230
PRO A 231
GLY A 232
THR A 233
None
0.63A 5x24A-4eppA:
undetectable
5x24A-4eppA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf2 ERYTHROCYTE BINDING
ANTIGEN 140


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
4 PHE A 476
PRO A 477
GLY A 478
THR A 479
None
0.52A 5x24A-4gf2A:
undetectable
5x24A-4gf2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0o PROTEIN ELYS

(Mus musculus)
PF16687
(ELYS-bb)
4 PHE A  38
GLY A  44
ASN A  43
LYS A  42
None
0.80A 5x24A-4i0oA:
undetectable
5x24A-4i0oA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
4 PRO A  56
GLY A  57
THR A  58
ASN A  82
None
1.00A 5x24A-4iwnA:
undetectable
5x24A-4iwnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj9 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE


(Bordetella
bronchiseptica)
PF02962
(CHMI)
4 PHE A  41
PRO A  42
GLY A  45
THR A  46
None
0.83A 5x24A-4jj9A:
undetectable
5x24A-4jj9A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I


(Escherichia
coli)
PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C)
4 PHE A 415
PRO A 416
GLY A 417
THR A 418
None
0.48A 5x24A-4js5A:
undetectable
5x24A-4js5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE


(Drosophila
melanogaster)
PF01144
(CoA_trans)
4 PRO A 429
GLY A 430
THR A 431
LYS A 432
None
1.01A 5x24A-4kgbA:
undetectable
5x24A-4kgbA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia)
PF01979
(Amidohydro_1)
4 PHE A 183
PRO A 184
GLY A 185
LYS A 187
None
None
None
EDO  A 403 (-2.8A)
0.97A 5x24A-4lfyA:
undetectable
5x24A-4lfyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohs FAR-RED FLUORESCENT
PROTEIN AQ143


(Actinia equina)
PF01353
(GFP)
4 PHE A 126
PRO A 127
GLY A 130
ASN A 129
None
0.87A 5x24A-4ohsA:
undetectable
5x24A-4ohsA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1


(Saccharomyces
cerevisiae)
PF12157
(DUF3591)
4 PRO A 504
GLY A 505
THR A 506
LYS A 507
None
0.95A 5x24A-4oy2A:
undetectable
5x24A-4oy2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE


(Gallus gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus)
PF01353
(GFP)
PF13499
(EF-hand_7)
4 PHE A 365
PRO A 366
GLY A 369
ASN A 368
None
0.79A 5x24A-4oy4A:
undetectable
5x24A-4oy4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE


(Bacillus
subtilis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 PHE A 132
PRO A 134
THR A 136
LYS A 137
None
0.99A 5x24A-4rjkA:
undetectable
5x24A-4rjkA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tza FLUORESCENT PROTEIN

(synthetic
construct)
no annotation 4 PHE C 125
PRO C 126
GLY C 129
ASN C 128
None
0.82A 5x24A-4tzaC:
undetectable
5x24A-4tzaC:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud1 N PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus)
PF00937
(Corona_nucleoca)
4 PRO A 152
GLY A 153
THR A 154
LYS A 155
None
1.02A 5x24A-4ud1A:
undetectable
5x24A-4ud1A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR


(Homo sapiens)
PF07686
(V-set)
4 PHE A  69
PRO A  70
GLY A  73
THR A  74
NAG  A 602 ( 2.9A)
None
None
NAG  A 602 ( 4.2A)
0.94A 5x24A-5d4kA:
undetectable
5x24A-5d4kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE


(Rhodobacter
sphaeroides)
PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ)
4 PHE A 598
PRO A 596
GLY A 599
ASN A 600
None
1.01A 5x24A-5ej1A:
undetectable
5x24A-5ej1A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT


(Pyrococcus
abyssi)
PF03833
(PolC_DP2)
4 PHE A 816
GLY A 819
THR A 820
ASN A 971
None
0.95A 5x24A-5ijlA:
undetectable
5x24A-5ijlA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II


(Streptomyces
sp. SirexAA-E)
PF02012
(BNR)
4 PRO A 486
GLY A 487
THR A 488
ASN A 507
None
0.93A 5x24A-5jwzA:
undetectable
5x24A-5jwzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
4 PHE A 391
PRO A 392
GLY A 393
LYS A 397
None
0.76A 5x24A-5kp7A:
0.0
5x24A-5kp7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9o DEOXYFRUCTOSYL-AMINO
ACID TRANSPORTER
PERIPLASMIC BINDING
PROTEIN


(Agrobacterium
fabrum)
PF00497
(SBP_bac_3)
4 PHE A 264
PRO A 265
GLY A 266
THR A 267
None
None
None
EDO  A 306 (-4.6A)
0.89A 5x24A-5l9oA:
undetectable
5x24A-5l9oA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus)
no annotation 4 PHE A 994
PRO A 995
GLY A 996
THR A 997
None
0.57A 5x24A-5n4lA:
undetectable
5x24A-5n4lA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN SA


(Trypanosoma
cruzi)
no annotation 4 PHE f 111
GLY f 109
THR f 110
ASN f 113
None
A  E1789 ( 3.9A)
None
U  E1761 ( 2.8A)
0.92A 5x24A-5optf:
undetectable
5x24A-5optf:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT PSAK 2


(Synechocystis
sp. PCC 6803)
no annotation 4 PHE k  61
GLY k  45
THR k  44
LYS k  43
None
0.75A 5x24A-5oy0k:
undetectable
5x24A-5oy0k:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Mycolicibacterium
smegmatis)
PF13561
(adh_short_C2)
4 PHE A 141
PRO A 142
GLY A 143
THR A 144
None
0.64A 5x24A-5t2uA:
undetectable
5x24A-5t2uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor)
no annotation 4 PHE A 248
PRO A 249
GLY A 252
ASN A 251
None
0.95A 5x24A-5ukgA:
undetectable
5x24A-5ukgA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7


(Homo sapiens)
PF00098
(zf-CCHC)
PF03828
(PAP_assoc)
5 PHE A1037
PRO A1038
GLY A1039
THR A1040
LYS A1041
None
0.95A 5x24A-5w0mA:
undetectable
5x24A-5w0mA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoz TRYPSIN PROTEIN
INHIBITOR 2


(Cicer arietinum)
no annotation 4 PHE A  83
GLY A  85
THR A  86
ASN A 136
None
0.51A 5x24A-5xozA:
undetectable
5x24A-5xozA:
12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 6 PHE A 226
PRO A 227
GLY A 228
THR A 229
ASN A 231
LYS A 232
LSN  A 502 (-4.7A)
LSN  A 502 (-3.7A)
LSN  A 502 (-3.4A)
LSN  A 502 (-3.9A)
LSN  A 502 (-4.3A)
LSN  A 502 (-2.9A)
0.39A 5x24A-5xxiA:
62.5
5x24A-5xxiA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yax SCFV1 ANTIBODY

(Homo sapiens)
no annotation 4 PHE A1045
PRO A1046
GLY A1047
THR A1048
None
0.75A 5x24A-5yaxA:
undetectable
5x24A-5yaxA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z4g SAHS4

(Ramazzottius
varieornatus)
no annotation 4 PHE A  90
PRO A  91
GLY A  92
THR A  93
None
0.70A 5x24A-5z4gA:
undetectable
5x24A-5z4gA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S2

(Leishmania
donovani)
no annotation 4 PHE B 111
GLY B 109
THR B 110
ASN B 113
None
A  11673 ( 3.9A)
None
U  11645 ( 3.2A)
0.90A 5x24A-6az1B:
undetectable
5x24A-6az1B:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0k IOTA-CARRAGEENAN
SULFATASE


(Pseudoalteromonas)
no annotation 4 PHE A 323
GLY A  65
THR A  66
LYS A 333
None
0.98A 5x24A-6b0kA:
undetectable
5x24A-6b0kA:
11.06