SIMILAR PATTERNS OF AMINO ACIDS FOR 5X24_A_LSNA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		5 PHE A 207
LEU A 299
VAL A 282
VAL A 306
LEU A 201
 None
 1.14A 5x24A-1b7eA:
undetectable		 5x24A-1b7eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 ALA A 385
ARG A 322
VAL A 354
GLY A 389
LEU A 419
 None
 1.04A 5x24A-1c0aA:
0.0		 5x24A-1c0aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 VAL A 111
VAL A 124
GLY A 145
THR A 201
LEU A 328
 None
 1.09A 5x24A-1dcuA:
undetectable		 5x24A-1dcuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 ALA A  34
PHE A 115
LEU A  33
GLY A  57
LEU A 119
 None
 1.00A 5x24A-1efvA:
0.0		 5x24A-1efvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		5 ALA A 112
LEU A 115
VAL A  51
GLY A  23
THR A  26
 None
 1.15A 5x24A-1g5bA:
0.1		 5x24A-1g5bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 ALA A 278
PHE A 274
VAL A 293
GLY A 296
LEU A 329
 None
 1.19A 5x24A-1j1wA:
0.0		 5x24A-1j1wA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		5 ALA A 120
LEU A  83
MET A  62
GLY A  52
LEU A 131
 None
 1.24A 5x24A-1j5sA:
undetectable		 5x24A-1j5sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 ALA A 179
PHE A 182
LEU A 134
VAL A  96
LEU A 224
 None
 1.11A 5x24A-1mt5A:
0.0		 5x24A-1mt5A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		6 ASN A 204
LEU A 233
ASP A 290
GLY A 293
THR A 298
LEU A 363
 None
None
None
DIF  A 501 (-3.8A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.86A 5x24A-1nr6A:
55.2		 5x24A-1nr6A:
76.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 PHE A 114
LEU A 233
ASP A 290
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
None
None
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.84A 5x24A-1nr6A:
55.2		 5x24A-1nr6A:
76.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A 237
LEU A 307
VAL A 309
VAL A 263
GLY A 296
 None
 1.13A 5x24A-1ofuA:
undetectable		 5x24A-1ofuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		5 ALA A 505
LEU A 583
GLY A 418
THR A 163
LEU A 148
 None
 1.16A 5x24A-1pemA:
undetectable		 5x24A-1pemA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 313
ARG A 373
LEU A 161
VAL A 376
THR A 208
 None
 1.24A 5x24A-1pffA:
undetectable		 5x24A-1pffA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		5 PHE A 214
LEU A 195
VAL A 116
GLY A 114
LEU A 220
 None
 1.24A 5x24A-1pjaA:
undetectable		 5x24A-1pjaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ALA A 288
PHE A 250
VAL A 343
GLY A 347
LEU A 166
 None
 1.08A 5x24A-1re5A:
0.3		 5x24A-1re5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		5 ALA A  59
LEU A  16
GLY A 100
THR A 103
LEU A  83
 None
 1.16A 5x24A-1tv8A:
undetectable		 5x24A-1tv8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		5 ALA A  95
ARG A 462
LEU A  96
VAL A 100
ASP A  21
 None
 1.21A 5x24A-1tz7A:
undetectable		 5x24A-1tz7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 ALA A 652
LEU A 585
MET A 503
THR A 709
LEU A 669
 None
 1.02A 5x24A-1v7vA:
undetectable		 5x24A-1v7vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 273
VAL A 268
VAL A 331
GLY A 325
THR A 305
 LEU  A 273 ( 0.6A)
VAL  A 268 ( 0.6A)
VAL  A 331 ( 0.6A)
GLY  A 325 ( 0.0A)
THR  A 305 ( 0.8A)
 1.13A 5x24A-1wqaA:
undetectable		 5x24A-1wqaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 ALA A 304
PHE A 451
ASN A 281
GLY A 357
THR A  33
 None
 1.03A 5x24A-1wzaA:
undetectable		 5x24A-1wzaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		5 ARG A  51
ASN A 139
VAL A  87
ASP A 105
GLY A 111
 None
 1.11A 5x24A-1xnyA:
undetectable		 5x24A-1xnyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		5 ALA A 346
VAL A 312
ASP A 285
GLY A 215
LEU A 294
 None
 1.19A 5x24A-1zmrA:
undetectable		 5x24A-1zmrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ALA A 229
LEU A  71
MET A 216
VAL A  68
GLY A  58
 None
None
GLA  A 529 ( 4.9A)
None
None
 1.21A 5x24A-2aj4A:
undetectable		 5x24A-2aj4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		5 ALA A 126
LEU A 115
VAL A 117
GLY A  88
LEU A  13
 None
 1.13A 5x24A-2bszA:
undetectable		 5x24A-2bszA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 LEU A  19
VAL A 127
ASP A 125
GLY A 123
LEU A  99
 None
 1.19A 5x24A-2cbrA:
undetectable		 5x24A-2cbrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 ALA A 221
LEU A 204
GLY A 225
THR A  90
LEU A  41
 None
 1.05A 5x24A-2d42A:
undetectable		 5x24A-2d42A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddz 190AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF04017
(DUF366) 		5 ALA A 169
PHE A 164
LEU A  37
GLY A 137
LEU A  99
 None
 1.13A 5x24A-2ddzA:
undetectable		 5x24A-2ddzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 ALA A  63
VAL A 121
VAL A  33
ASP A  56
GLY A  10
 None
 1.19A 5x24A-2ppvA:
undetectable		 5x24A-2ppvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psb YERB PROTEIN

(Bacillus
subtilis) 		PF11258
(DUF3048)
PF17479
(DUF3048_C) 		5 ALA A  69
PHE A  89
LEU A  49
VAL A  79
VAL A  82
 None
 1.19A 5x24A-2psbA:
undetectable		 5x24A-2psbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		5 PHE A 393
LEU A 214
VAL A 222
VAL A 431
THR A 356
 None
 1.08A 5x24A-2pyjA:
undetectable		 5x24A-2pyjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		5 ALA A  83
LEU A  84
VAL A 109
ASP A 111
GLY A  73
 None
 1.19A 5x24A-2q8nA:
undetectable		 5x24A-2q8nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 161
LEU A 159
VAL A 231
GLY A 193
LEU A 365
 None
 1.06A 5x24A-2qygA:
undetectable		 5x24A-2qygA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 PHE A 461
LEU A 482
VAL A 379
MET A 382
VAL A 442
 None
 1.15A 5x24A-2r9vA:
undetectable		 5x24A-2r9vA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 ALA A 131
PHE A 141
ASN A 108
LEU A 164
LEU A 145
 None
 1.19A 5x24A-2rafA:
undetectable		 5x24A-2rafA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yho E3 UBIQUITIN-PROTEIN
LIGASE MYLIP

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		5 ALA A 412
LEU A 415
VAL A 425
GLY A 403
LEU A 433
 None
 1.24A 5x24A-2yhoA:
undetectable		 5x24A-2yhoA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 190
VAL A 200
ASP A 201
GLY A 204
LEU A 160
 None
 1.17A 5x24A-3c0iA:
undetectable		 5x24A-3c0iA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA

(Methylosinus
trichosporium) 		PF02461
(AMO) 		5 PHE B  92
VAL B 130
VAL B  98
GLY B 100
LEU B  31
 None
 1.11A 5x24A-3chxB:
undetectable		 5x24A-3chxB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmf DETHIOBIOTIN
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 ALA A 215
LEU A 196
VAL A 192
GLY A 165
LEU A 224
 None
None
None
CSX  A 163 ( 3.7A)
None
 1.08A 5x24A-3fmfA:
undetectable		 5x24A-3fmfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		5 ALA A 275
LEU A 167
GLY A 298
THR A 312
LEU A 209
 None
 1.21A 5x24A-3i3vA:
undetectable		 5x24A-3i3vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		5 LEU A2334
VAL A2330
VAL A2205
GLY A2203
LEU A1904
 None
 1.14A 5x24A-3jbzA:
undetectable		 5x24A-3jbzA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khp MAOC FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 LEU A 139
VAL A 118
GLY A  84
THR A  55
LEU A 280
 None
 0.97A 5x24A-3khpA:
undetectable		 5x24A-3khpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2p DNA LIGASE 3

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ALA A 643
PHE A 611
VAL A 607
GLY A 627
THR A 709
 None
 1.18A 5x24A-3l2pA:
undetectable		 5x24A-3l2pA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		5 ALA A 223
VAL A 210
VAL A  87
ASP A  88
GLY A  93
 None
 0.98A 5x24A-3l7oA:
undetectable		 5x24A-3l7oA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 ALA A 204
VAL A 400
VAL A  50
GLY A  43
THR A 156
 None
 1.22A 5x24A-3ldoA:
undetectable		 5x24A-3ldoA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf0 NITROGEN REGULATORY
PROTEIN P-II

(Mycobacterium
tuberculosis) 		PF00543
(P-II) 		5 LEU A   3
VAL A  65
VAL A  25
GLY A  27
LEU A  13
 None
 0.83A 5x24A-3lf0A:
undetectable		 5x24A-3lf0A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		5 ALA A 183
PHE A 140
LEU A 180
VAL A 172
GLY A 144
 None
 1.13A 5x24A-3muqA:
undetectable		 5x24A-3muqA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A  77
VAL A  81
VAL A  67
GLY A 346
LEU A 353
 None
 1.12A 5x24A-3ogrA:
undetectable		 5x24A-3ogrA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1s Z13E1 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE H  78
VAL H   2
VAL H 114
GLY H 116
THR H 119
 None
 1.20A 5x24A-3q1sH:
undetectable		 5x24A-3q1sH:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6m YEAZ, RESUSCITATION
PROMOTING FACTOR

(Vibrio
parahaemolyticus) 		PF00814
(Peptidase_M22) 		6 ALA A  86
LEU A  88
VAL A 211
GLY A  77
THR A   9
LEU A  40
 None
 1.47A 5x24A-3r6mA:
undetectable		 5x24A-3r6mA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 ALA A  55
VAL A 177
VAL A 208
ASP A  48
GLY A  12
 None
 1.15A 5x24A-3rh9A:
undetectable		 5x24A-3rh9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sci SPIKE GLYCOPROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF09408
(Spike_rec_bind) 		5 VAL E 496
VAL E 394
ASP E 393
GLY E 391
THR E 487
 None
 1.24A 5x24A-3sciE:
undetectable		 5x24A-3sciE:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		5 ALA B  40
LEU B 161
VAL B 165
VAL B  93
THR A   6
 PEB  B 204 ( 4.0A)
None
None
None
None
 1.23A 5x24A-3v57B:
undetectable		 5x24A-3v57B:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		5 ALA A 369
LEU A 370
VAL A 384
GLY A  11
THR A 112
 None
 1.15A 5x24A-3zjkA:
undetectable		 5x24A-3zjkA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		5 ALA A 280
ASN A 210
LEU A 312
VAL A 315
LEU A 273
 None
 1.04A 5x24A-3zscA:
undetectable		 5x24A-3zscA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		5 LEU A   7
VAL A   5
VAL A  73
GLY A 161
LEU A 127
 None
 1.23A 5x24A-4aukA:
undetectable		 5x24A-4aukA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a POLY(A) RIBONUCLEASE
POP2

(Saccharomyces
cerevisiae) 		PF04857
(CAF1) 		5 ASN B 172
VAL B  73
MET B  69
ASP B 166
LEU B  83
 None
 1.23A 5x24A-4b8aB:
undetectable		 5x24A-4b8aB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		5 ALA B 164
LEU B 174
VAL B 160
GLY B 177
THR B 203
 None
 1.07A 5x24A-4g56B:
undetectable		 5x24A-4g56B:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 PHE A 334
LEU A  28
VAL A 123
VAL A  82
GLY A 115
LEU A 311
 None
 1.38A 5x24A-4gkvA:
undetectable		 5x24A-4gkvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE

(Homo sapiens) 		PF05301
(Acetyltransf_16) 		5 PHE A 186
ASN A 181
LEU A 104
VAL A 106
LEU A 164
 None
 1.15A 5x24A-4gs4A:
undetectable		 5x24A-4gs4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxd RNA-DIRECTED RNA
POLYMERASE L

(Dugbe
orthonairovirus) 		PF02338
(OTU) 		5 PHE B  29
VAL B 147
VAL B 121
THR B  19
LEU B   4
 None
 1.24A 5x24A-4hxdB:
undetectable		 5x24A-4hxdB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI

(Caulobacter
vibrioides) 		PF06230
(DUF1009) 		5 ALA A 213
LEU A 156
VAL A 158
VAL A 178
GLY A 176
 None
 1.17A 5x24A-4j6eA:
undetectable		 5x24A-4j6eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07732
(Cu-oxidase_3) 		5 PHE A 120
ASN A 185
VAL A 158
VAL A  60
GLY A  58
 CU  A 407 ( 4.9A)
None
None
None
None
 0.94A 5x24A-4kntA:
undetectable		 5x24A-4kntA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9f TRANSCRIPTIONAL
REGULATOR, PPSR

(Rhodobacter
sphaeroides) 		PF00989
(PAS) 		5 ALA A 179
LEU A 183
GLY A 192
THR A 169
LEU A 248
 None
 1.19A 5x24A-4l9fA:
undetectable		 5x24A-4l9fA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg4 PHOSPHONOMUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 ALA A  28
VAL A  69
MET A  66
VAL A  49
GLY A  45
 None
None
None
None
CL  A 301 (-3.4A)
 1.12A 5x24A-4mg4A:
undetectable		 5x24A-4mg4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		5 LEU A 120
VAL A 149
VAL A 160
ASP A 161
GLY A 135
 None
 0.86A 5x24A-4ml9A:
undetectable		 5x24A-4ml9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF05138
(PaaA_PaaC) 		5 ALA A  31
VAL A  94
VAL A 112
ASP A 113
GLY A 116
 None
 1.01A 5x24A-4mudA:
0.8		 5x24A-4mudA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 114
VAL A 236
ASP A 298
GLY A 301
THR A 306
 3QZ  A 601 ( 4.1A)
None
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 3.0A)
HEM  A 600 ( 3.2A)
 1.20A 5x24A-4nkyA:
42.6		 5x24A-4nkyA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		5 ALA A 222
PHE A 220
LEU A 209
VAL A 237
GLY A 235
 None
 1.24A 5x24A-4p05A:
undetectable		 5x24A-4p05A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF08003
(Methyltransf_9) 		5 PHE A 174
LEU A 183
VAL A 125
GLY A 146
LEU A  27
 None
None
ACT  A 403 ( 4.9A)
None
None
 1.15A 5x24A-4p7cA:
undetectable		 5x24A-4p7cA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		5 PHE A 175
LEU A 117
GLY A 180
THR A 228
LEU A 221
 None
 1.20A 5x24A-4pjuA:
undetectable		 5x24A-4pjuA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		5 ALA A  98
ASN A  58
LEU A  95
GLY A  53
LEU A  68
 None
 1.24A 5x24A-4rnzA:
undetectable		 5x24A-4rnzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 ALA A 215
LEU A 196
VAL A 192
GLY A 165
LEU A 224
 None
CTP  A 301 ( 4.4A)
None
None
None
 1.07A 5x24A-4wopA:
undetectable		 5x24A-4wopA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A  95
VAL A  79
GLY A 139
THR A 286
LEU A 143
 None
 1.19A 5x24A-4x0oA:
undetectable		 5x24A-4x0oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		5 LEU A 133
VAL A 131
VAL A 117
GLY A 152
LEU A  89
 None
 1.18A 5x24A-4yogA:
undetectable		 5x24A-4yogA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ALA A 105
VAL A 120
MET A 121
VAL A  88
GLY A  92
 None
 1.21A 5x24A-4yswA:
undetectable		 5x24A-4yswA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		5 ALA A  23
ARG A 334
VAL A 352
ASP A 355
GLY A 357
 None
 1.16A 5x24A-5bwiA:
undetectable		 5x24A-5bwiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 VAL A 174
VAL A 204
GLY A 206
THR A 217
LEU A 247
 None
 1.19A 5x24A-5c3mA:
undetectable		 5x24A-5c3mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		5 ALA A 284
PHE A 238
VAL A 114
GLY A 268
LEU A 210
 None
 1.00A 5x24A-5cbmA:
undetectable		 5x24A-5cbmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 ALA B 610
LEU B 500
VAL B 504
VAL B 617
LEU B 682
 None
 1.02A 5x24A-5dlqB:
undetectable		 5x24A-5dlqB:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGK

(Escherichia
coli) 		PF02626
(CT_A_B) 		5 ALA A 270
ASN A 247
LEU A  32
GLY A 232
LEU A 211
 None
 1.07A 5x24A-5dudA:
undetectable		 5x24A-5dudA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ALA A 107
VAL A 122
MET A 123
VAL A  89
GLY A  93
 None
 1.15A 5x24A-5epgA:
undetectable		 5x24A-5epgA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Entamoeba
histolytica) 		no annotation 5 PHE A 140
LEU A  58
VAL A 126
GLY A 124
LEU A  22
 None
 1.14A 5x24A-5f3qA:
undetectable		 5x24A-5f3qA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 ASN A 232
LEU A 121
VAL A 125
ASP A 225
LEU A 511
 None
X2N  A 590 (-4.6A)
None
None
None
 1.24A 5x24A-5fsaA:
30.4		 5x24A-5fsaA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		5 ALA A 280
VAL A 225
VAL A 231
ASP A 233
GLY A 248
 None
 1.24A 5x24A-5gl9A:
undetectable		 5x24A-5gl9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		5 ALA A 229
VAL A  48
ASP A 210
GLY A  56
LEU A 284
 None
 1.11A 5x24A-5hstA:
undetectable		 5x24A-5hstA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A 293
LEU A 290
VAL A 263
ASP A 264
GLY A 268
 None
 1.02A 5x24A-5hwsA:
undetectable		 5x24A-5hwsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ALA A1091
VAL A 871
VAL A 887
ASP A1403
LEU A1378
 None
 1.21A 5x24A-5iy9A:
undetectable		 5x24A-5iy9A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 2

(Mus musculus) 		PF02251
(PA28_alpha)
PF02252
(PA28_beta) 		5 VAL B 185
VAL B 201
ASP B 205
THR B 173
LEU B 114
 None
 1.09A 5x24A-5mx5B:
undetectable		 5x24A-5mx5B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 ALA A 232
PHE A 289
LEU A  29
GLY A 236
LEU A 285
 None
 1.05A 5x24A-5o0jA:
undetectable		 5x24A-5o0jA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 ALA A 351
LEU A 374
ASP A 247
GLY A 307
LEU A 252
 None
 1.16A 5x24A-5o3wA:
undetectable		 5x24A-5o3wA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  87
PHE A  63
VAL A  77
VAL A  71
GLY A  95
 None
 1.15A 5x24A-5uidA:
undetectable		 5x24A-5uidA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6

(Homo sapiens) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 LEU A 334
VAL A 423
VAL A 306
GLY A 298
THR A 666
 None
 1.24A 5x24A-5vxzA:
undetectable		 5x24A-5vxzA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 5 ALA A 399
ASN A 370
VAL A 344
ASP A 345
GLY A 293
 None
None
None
None
PEG  A 502 (-4.3A)
 1.21A 5x24A-5wkaA:
undetectable		 5x24A-5wkaA:
9.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 12 ALA A 106
ARG A 108
PHE A 114
ASN A 204
LEU A 233
VAL A 237
MET A 240
VAL A 292
ASP A 293
GLY A 296
THR A 301
LEU A 366
 LSN  A 501 ( 3.9A)
LSN  A 501 (-3.2A)
LSN  A 503 (-3.8A)
LSN  A 501 (-3.7A)
LSN  A 501 ( 4.0A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.3A)
LSN  A 501 (-4.9A)
LSN  A 501 (-3.9A)
LSN  A 501 (-3.5A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
 0.30A 5x24A-5xxiA:
62.5		 5x24A-5xxiA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyf ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
TERF1-INTERACTING
NUCLEAR FACTOR 2

(Homo sapiens) 		no annotation 5 ALA B 528
PHE A  37
LEU B 529
GLY A   8
LEU A 158
 None
 1.22A 5x24A-5xyfB:
undetectable		 5x24A-5xyfB:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 PHE B  83
VAL B  12
MET B  16
VAL B  22
LEU B  33
 None
 1.20A 5x24A-5y58B:
undetectable		 5x24A-5y58B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 VAL A 297
MET A 300
VAL A 339
ASP A 340
GLY A 341
 None
 1.07A 5x24A-5yvsA:
undetectable		 5x24A-5yvsA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 ARG A 487
VAL A 408
VAL A 291
GLY A 569
THR A 572
 None
 1.19A 5x24A-5ze4A:
undetectable		 5x24A-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 5 ALA A 204
VAL A 400
VAL A  50
GLY A  43
THR A 156
 None
 1.21A 5x24A-6eoeA:
undetectable		 5x24A-6eoeA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 LEU A 529
VAL A 532
ASP A 597
THR A 710
LEU A 722
 None
 1.20A 5x24A-6fuyA:
undetectable		 5x24A-6fuyA:
9.34