SIMILAR PATTERNS OF AMINO ACIDS FOR 5X23_A_LSNA504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE


(Hordeum vulgare)
PF00332
(Glyco_hydro_17)
4 ILE A 274
PHE A 306
ASN A  25
PRO A 245
None
1.07A 5x23A-1aq0A:
0.0
5x23A-1aq0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN


(Salmonella
enterica)
PF00496
(SBP_bac_5)
4 ILE A 450
ASN A 437
PRO A 319
THR A 318
None
0.94A 5x23A-1b2hA:
0.0
5x23A-1b2hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE


(Pisum sativum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ILE A 417
PHE A 385
ASN A 388
PRO A 420
None
1.10A 5x23A-1dxlA:
0.0
5x23A-1dxlA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 PHE A 277
ILE A 108
ASN A 312
PRO A  24
None
0.97A 5x23A-1f8wA:
0.0
5x23A-1f8wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 ILE A 212
ASN A 409
THR A 332
PHE A 327
None
1.02A 5x23A-1g8kA:
0.0
5x23A-1g8kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jb7 TELOMERE-BINDING
PROTEIN BETA SUBUNIT


(Sterkiella nova)
PF07404
(TEBP_beta)
4 PHE B  14
PRO B 131
THR B 132
PRO B 135
None
1.15A 5x23A-1jb7B:
undetectable
5x23A-1jb7B:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica)
PF00069
(Pkinase)
4 PHE A 136
ILE A 331
THR A 213
PHE A 216
None
0.92A 5x23A-1kobA:
0.0
5x23A-1kobA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00632
(HECT)
4 PHE A 657
ILE A 660
PHE A 631
PHE A 682
None
1.11A 5x23A-1nd7A:
0.0
5x23A-1nd7A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q40 MRNA EXPORT FACTOR
MEX67


(Candida
albicans)
no annotation 4 ILE B 498
ASN B 368
PRO B 469
PRO B 400
None
1.14A 5x23A-1q40B:
undetectable
5x23A-1q40B:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus)
PF01403
(Sema)
4 PHE A 226
PHE A 245
PRO A 210
THR A 204
None
1.10A 5x23A-1q47A:
undetectable
5x23A-1q47A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2x CAG-Z

(Helicobacter
pylori)
PF09053
(CagZ)
4 PHE A  31
ILE A  32
ASN A  58
PRO A 137
None
1.11A 5x23A-1s2xA:
undetectable
5x23A-1s2xA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus)
PF00063
(Myosin_head)
4 ILE A 105
PHE A 465
ASN A 466
THR A  75
None
0.83A 5x23A-1w8jA:
undetectable
5x23A-1w8jA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii)
PF01266
(DAO)
4 ILE B 318
ASN B 199
PRO B 312
THR B 311
None
1.12A 5x23A-1y56B:
undetectable
5x23A-1y56B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY


(Streptococcus
pneumoniae)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 PHE A  28
ILE A  15
PRO A  66
THR A  65
None
1.15A 5x23A-1ydfA:
undetectable
5x23A-1ydfA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yns E-1 ENZYME

(Homo sapiens)
no annotation 4 ILE A 151
PRO A  23
THR A  22
PHE A 131
None
1.05A 5x23A-1ynsA:
undetectable
5x23A-1ynsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D


(Methanosarcina
mazei)
PF01142
(TruD)
4 ILE A 277
THR A 346
PRO A 340
PHE A 348
None
1.08A 5x23A-1z2zA:
undetectable
5x23A-1z2zA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo2 NUCLEAR TRANSPORT
FACTOR 2


(Cryptosporidium
parvum)
PF02136
(NTF2)
4 PHE A  69
ILE A  71
PHE A 102
PHE A 106
None
0.71A 5x23A-1zo2A:
undetectable
5x23A-1zo2A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj0 THIOREDOXIN-RELATED
TRANSMEMBRANE
PROTEIN 2


(Homo sapiens)
PF00085
(Thioredoxin)
4 PHE A 126
ILE A  30
PRO A  46
PHE A  44
None
1.15A 5x23A-2dj0A:
undetectable
5x23A-2dj0A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT


(Gallus gallus)
PF00079
(Serpin)
4 PHE A 195
ILE A 193
PHE A 401
PRO A  32
None
1.15A 5x23A-2dutA:
undetectable
5x23A-2dutA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE


(Candida
tropicalis)
PF00106
(adh_short)
4 ILE A 547
PHE A 262
ASN A 310
PRO A 523
None
1.15A 5x23A-2et6A:
undetectable
5x23A-2et6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN


(Escherichia
coli)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 PHE A 122
ILE A 125
PHE A 102
PRO A 132
None
1.07A 5x23A-2gepA:
undetectable
5x23A-2gepA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0q TELOMERE-BINDING
PROTEIN BETA SUBUNIT


(Sterkiella nova)
PF07404
(TEBP_beta)
4 PHE B  14
PRO B 131
THR B 132
PRO B 135
None
1.14A 5x23A-2i0qB:
undetectable
5x23A-2i0qB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT


(Thermotoga
maritima)
PF01174
(SNO)
4 PHE D 129
ILE D 121
PHE D 169
PHE D  75
None
0.85A 5x23A-2issD:
undetectable
5x23A-2issD:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 ASN A 515
PRO A 766
THR A 765
PRO A 734
None
1.17A 5x23A-2iukA:
undetectable
5x23A-2iukA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iun AVIAN ADENOVIRUS
CELO LONG FIBRE


(Fowl
aviadenovirus A)
PF16812
(AdHead_fibreRBD)
4 ILE A 653
PRO A 723
THR A 781
PHE A 779
None
1.17A 5x23A-2iunA:
undetectable
5x23A-2iunA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
5 ILE A  74
ASN A 217
PRO A 363
THR A 364
PRO A 367
None
None
None
None
225  A 501 ( 4.7A)
0.58A 5x23A-2nnjA:
58.2
5x23A-2nnjA:
78.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oez UPF0289 PROTEIN
VP2528


(Vibrio
parahaemolyticus)
PF07072
(ZapD)
4 PHE A 221
ILE A 214
PRO A 205
PHE A 240
None
1.00A 5x23A-2oezA:
undetectable
5x23A-2oezA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxg OUTER MEMBRANE
PROTEIN


(Xanthomonas
citri)
PF04355
(SmpA_OmlA)
4 PHE A  89
ILE A  18
PRO A  42
THR A  41
None
1.08A 5x23A-2pxgA:
undetectable
5x23A-2pxgA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc5 STREPTOGRAMIN B
LACTONASE


(Staphylococcus
cohnii)
no annotation 4 PHE A 198
ILE A 230
PRO A 221
PRO A 227
PHE  A 198 ( 1.3A)
ILE  A 230 ( 0.6A)
PRO  A 221 ( 1.1A)
PRO  A 227 ( 1.1A)
1.08A 5x23A-2qc5A:
undetectable
5x23A-2qc5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Yersinia
enterocolitica)
PF13416
(SBP_bac_8)
4 ILE A 195
PHE A 396
THR A 207
PHE A 387
None
0.84A 5x23A-2uvjA:
undetectable
5x23A-2uvjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voa EXODEOXYRIBONUCLEASE
III


(Archaeoglobus
fulgidus)
PF03372
(Exo_endo_phos)
4 ILE A 102
PRO A 225
THR A 223
PHE A 137
None
1.12A 5x23A-2voaA:
undetectable
5x23A-2voaA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE


(Saccharomyces
cerevisiae)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
4 ILE A 248
ASN A  75
THR A 159
PHE A 157
None
1.09A 5x23A-2xpzA:
undetectable
5x23A-2xpzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt4 MCBG-LIKE PROTEIN

(Xanthomonas
albilineans)
PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4)
4 PHE A  41
ILE A  64
THR A  69
PHE A  51
None
1.16A 5x23A-2xt4A:
undetectable
5x23A-2xt4A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE


(Aspergillus
fumigatus)
PF13088
(BNR_2)
4 ILE A 211
PRO A 125
THR A 126
PRO A 221
None
1.12A 5x23A-2xziA:
undetectable
5x23A-2xziA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE


(Burkholderia
cepacia)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 PHE A  81
ILE A   5
ASN A 152
PHE A 165
None
None
None
ACT  A1463 (-3.7A)
1.13A 5x23A-2y0eA:
undetectable
5x23A-2y0eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN


(Yersinia pestis)
PF00496
(SBP_bac_5)
4 ILE A 450
ASN A 437
PRO A 319
THR A 318
None
0.88A 5x23A-2z23A:
undetectable
5x23A-2z23A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2n VIRGINIAMYCIN B
LYASE


(Staphylococcus
aureus)
no annotation 4 PHE A 156
ILE A 188
PRO A 179
PRO A 185
None
1.16A 5x23A-2z2nA:
undetectable
5x23A-2z2nA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2n VIRGINIAMYCIN B
LYASE


(Staphylococcus
aureus)
no annotation 4 PHE A 198
ILE A 230
PRO A 221
PRO A 227
None
1.09A 5x23A-2z2nA:
undetectable
5x23A-2z2nA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Archaeoglobus
fulgidus)
PF01336
(tRNA_anti-codon)
PF08489
(DUF1743)
4 ILE A 336
PHE A 287
PRO A 303
THR A 304
None
0.91A 5x23A-3au7A:
undetectable
5x23A-3au7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccq 50S RIBOSOMAL
PROTEIN L4P


(Haloarcula
marismortui)
PF00573
(Ribosomal_L4)
4 ILE C  31
ASN C 219
PRO C 137
THR C 118
None
G  0 672 ( 3.6A)
None
None
0.90A 5x23A-3ccqC:
undetectable
5x23A-3ccqC:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpx AMINOPEPTIDASE, M42
FAMILY


(Cytophaga
hutchinsonii)
PF05343
(Peptidase_M42)
4 ILE A 288
PRO A 143
THR A 142
PHE A 133
None
1.15A 5x23A-3cpxA:
undetectable
5x23A-3cpxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1


(Thermotoga
maritima)
PF13507
(GATase_5)
4 ILE D  46
PHE D 204
ASN D  26
PRO D 187
None
0.92A 5x23A-3d54D:
undetectable
5x23A-3d54D:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3due PUTATIVE PERIPLASMIC
PROTEIN


(Bacteroides
vulgatus)
PF11396
(PepSY_like)
4 PHE A  43
PHE A  66
PRO A  32
PHE A  74
None
1.00A 5x23A-3dueA:
undetectable
5x23A-3dueA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ha4 MIX1

(Leishmania
major)
no annotation 4 ILE A 170
ASN A 148
THR A 117
PRO A 113
None
1.00A 5x23A-3ha4A:
undetectable
5x23A-3ha4A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR


(Lactobacillus
acidophilus)
PF13377
(Peripla_BP_3)
4 ILE A 285
ASN A  71
PRO A 184
THR A 185
None
1.09A 5x23A-3hs3A:
undetectable
5x23A-3hs3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV


(Corynebacterium
glutamicum)
PF00465
(Fe-ADH)
4 ILE A 178
PHE A 285
ASN A 202
PRO A 304
None
0.93A 5x23A-3iv7A:
undetectable
5x23A-3iv7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf8 PROTEIN TEN1

(Candida
tropicalis)
PF12658
(Ten1)
4 ILE B  82
ASN B  59
PRO B  48
PRO B   8
None
0.86A 5x23A-3kf8B:
undetectable
5x23A-3kf8B:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN


(Coxiella
burnetii)
PF07515
(TraI_2_C)
4 ILE A 176
PHE A 147
ASN A 145
PHE A  68
None
1.12A 5x23A-3kq5A:
undetectable
5x23A-3kq5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Hahella
chejuensis)
PF13407
(Peripla_BP_4)
4 ILE A 244
PHE A 253
PRO A 232
THR A 231
None
1.01A 5x23A-3ksmA:
undetectable
5x23A-3ksmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE


(Staphylococcus
aureus)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 ILE A 374
PRO A 476
THR A 464
PRO A 462
None
None
NA  A 498 (-3.9A)
None
1.12A 5x23A-3kzwA:
undetectable
5x23A-3kzwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfz ASPARTOACYLASE-2

(Mus musculus)
PF04952
(AstE_AspA)
4 ILE A 127
PHE A 281
PRO A 150
PHE A 251
3NF  A 322 (-4.0A)
None
None
None
1.01A 5x23A-3nfzA:
undetectable
5x23A-3nfzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
4 ILE A 830
PHE A 783
THR A 872
PRO A 786
None
1.09A 5x23A-3nzuA:
undetectable
5x23A-3nzuA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2e BROMODOMAIN AND WD
REPEAT-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00439
(Bromodomain)
4 PHE A1411
ILE A1329
PHE A1386
PRO A1341
None
1.15A 5x23A-3q2eA:
undetectable
5x23A-3q2eA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE


(Paenarthrobacter
aurescens)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
4 PHE A 431
PRO A 133
PRO A 483
PHE A 135
None
1.16A 5x23A-3rcnA:
undetectable
5x23A-3rcnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Roseovarius sp.
TM1035)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 PHE A  94
ILE A  91
PHE A  74
THR A  83
None
1.08A 5x23A-3rcyA:
undetectable
5x23A-3rcyA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans)
PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set)
4 PHE A 239
ILE A 435
THR A 316
PHE A 319
None
0.83A 5x23A-3utoA:
undetectable
5x23A-3utoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae)
PF00079
(Serpin)
4 PHE A 380
ILE A 377
PHE A  13
THR A 269
None
0.89A 5x23A-3vvjA:
undetectable
5x23A-3vvjA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea)
no annotation 4 PHE A 321
ILE A 306
PHE A 346
PRO A 446
None
None
None
TRQ  A 581 ( 3.6A)
1.09A 5x23A-3wevA:
undetectable
5x23A-3wevA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA


(Streptococcus
pneumoniae)
PF13306
(LRR_5)
4 ILE A 322
ASN A 293
PRO A 279
THR A 278
None
0.98A 5x23A-4cp6A:
undetectable
5x23A-4cp6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE


(Pseudomonas sp.
ADP)
PF01425
(Amidase)
4 ILE A 444
PHE A 417
THR A 379
PHE A 307
None
1.05A 5x23A-4cp8A:
undetectable
5x23A-4cp8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans)
PF14884
(EFF-AFF)
4 PHE A 191
ILE A  83
PRO A  22
THR A  21
None
1.13A 5x23A-4cylA:
undetectable
5x23A-4cylA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djt GTP-BINDING NUCLEAR
PROTEIN GSP1


(Encephalitozoon
cuniculi)
PF00071
(Ras)
4 PHE A  59
ILE A  10
PHE A 169
PRO A 115
None
0.70A 5x23A-4djtA:
undetectable
5x23A-4djtA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doi CHALCONE--FLAVONONE
ISOMERASE 1


(Arabidopsis
thaliana)
PF02431
(Chalcone)
4 ILE A  95
PHE A 100
ASN A  68
PHE A  40
None
1.13A 5x23A-4doiA:
undetectable
5x23A-4doiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN


(Schizosaccharomyces
pombe)
PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind)
4 ILE A1114
PHE A1128
PRO A1093
PRO A1126
None
1.06A 5x23A-4fbqA:
undetectable
5x23A-4fbqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgc NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE


(Bacillus
subtilis)
PF14489
(QueF)
4 PHE A  51
PHE A 122
THR A 134
PRO A 132
None
1.08A 5x23A-4fgcA:
undetectable
5x23A-4fgcA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
4 PHE A 680
ILE A 557
PRO A 549
PHE A 550
None
1.15A 5x23A-4gl2A:
undetectable
5x23A-4gl2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana)
PF00491
(Arginase)
4 PHE A 265
ILE A 247
PRO A 291
PRO A 253
None
1.08A 5x23A-4iu4A:
undetectable
5x23A-4iu4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2k TRYPSIN INHIBITOR

(Enterolobium
contortisiliquum)
PF00197
(Kunitz_legume)
4 PHE A  78
ILE A 106
THR A  35
PRO A  41
None
1.07A 5x23A-4j2kA:
undetectable
5x23A-4j2kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juu EPIMERASE

(Xanthomonas
campestris)
PF05544
(Pro_racemase)
4 ILE A 131
PRO A 115
THR A 114
PHE A  78
None
0.93A 5x23A-4juuA:
undetectable
5x23A-4juuA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1


(Rattus
norvegicus)
PF00245
(Alk_phosphatase)
4 PHE A  39
ILE A 354
PHE A 334
PRO A  68
None
1.12A 5x23A-4kjdA:
undetectable
5x23A-4kjdA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN


(Escherichia
coli)
PF00989
(PAS)
4 PHE C 102
ILE C  84
PRO C 149
THR C 160
None
1.06A 5x23A-4lryC:
undetectable
5x23A-4lryC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 PHE A 345
ILE A 344
PRO A 334
THR A 333
None
1.12A 5x23A-4lxfA:
undetectable
5x23A-4lxfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00171
(Aldedh)
4 ILE A 282
ASN A 276
THR A 224
PHE A 154
NO3  A 502 (-4.8A)
None
None
None
1.13A 5x23A-4o6rA:
undetectable
5x23A-4o6rA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron)
PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos)
4 PHE A  55
ILE A  52
ASN A  72
PRO A 107
None
1.10A 5x23A-4oueA:
undetectable
5x23A-4oueA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima)
PF00005
(ABC_tran)
4 PHE A 354
PHE A 548
THR A 520
PHE A 522
None
1.01A 5x23A-4q7kA:
undetectable
5x23A-4q7kA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE


(Crassicarpon
hotsonii)
PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
4 PHE A 230
ILE A 233
PRO A 457
THR A 438
None
1.18A 5x23A-4qi4A:
undetectable
5x23A-4qi4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli)
PF00557
(Peptidase_M24)
4 PHE A 389
ILE A 411
PHE A 332
THR A 316
None
1.15A 5x23A-4qr8A:
undetectable
5x23A-4qr8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B


(Pseudobacteroides
cellulosolvens)
PF00963
(Cohesin)
4 ILE A1061
PHE A1076
PRO A1099
PHE A1103
None
1.10A 5x23A-4umsA:
undetectable
5x23A-4umsA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus)
no annotation 4 PHE B 139
ILE B 180
PHE B 158
PHE B 211
None
1.05A 5x23A-4w5uB:
undetectable
5x23A-4w5uB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8


(Homo sapiens)
PF03540
(TFIID_30kDa)
PF07524
(Bromo_TP)
4 ILE B  93
PHE A 144
THR B  83
PRO B  88
None
1.15A 5x23A-4wv4B:
undetectable
5x23A-4wv4B:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyk NTF2-RELATED EXPORT
PROTEIN 1


(Homo sapiens)
PF02136
(NTF2)
4 PHE B  70
ILE B  72
PHE B 109
PHE B 113
None
0.65A 5x23A-4wykB:
undetectable
5x23A-4wykB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF03734
(YkuD)
4 PHE A  61
PHE A 205
PRO A 116
PRO A 281
GOL  A 403 ( 4.8A)
None
None
None
1.16A 5x23A-4y4vA:
undetectable
5x23A-4y4vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
4 PHE C 252
ILE C 446
PHE C 136
PRO C 243
None
1.07A 5x23A-5aa5C:
undetectable
5x23A-5aa5C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG


(Homo sapiens)
PF00632
(HECT)
4 PHE A 638
ILE A 641
PHE A 612
PHE A 663
None
1.10A 5x23A-5c7mA:
undetectable
5x23A-5c7mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3


(Homo sapiens)
PF03571
(Peptidase_M49)
4 ILE A 485
PHE A 363
THR A 481
PRO A 479
None
1.06A 5x23A-5e3cA:
undetectable
5x23A-5e3cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enf PH-INTERACTING
PROTEIN


(Homo sapiens)
PF00439
(Bromodomain)
4 PHE A1414
ILE A1332
PHE A1389
PRO A1344
None
1.15A 5x23A-5enfA:
undetectable
5x23A-5enfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es2 UNCHARACTERIZED
PROTEIN LPG0634


(Legionella
pneumophila)
PF16848
(SoDot-IcmSS)
4 ILE A  35
ASN A  54
THR A  22
PHE A  19
None
1.04A 5x23A-5es2A:
undetectable
5x23A-5es2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7


(Homo sapiens)
PF00575
(S1)
PF00623
(RNA_pol_Rpb1_2)
PF01192
(RNA_pol_Rpb6)
PF03876
(SHS2_Rpb7-N)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 ILE F  92
PHE A 397
ASN A 398
PRO G  15
None
1.05A 5x23A-5iy9F:
undetectable
5x23A-5iy9F:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF03971
(IDH)
4 PHE A 394
ILE A 391
PHE A 401
PRO A 410
None
0.97A 5x23A-5kvuA:
undetectable
5x23A-5kvuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG)
4 ILE A 241
PRO A 263
THR A 262
PRO A 260
None
1.05A 5x23A-5l5gA:
undetectable
5x23A-5l5gA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula)
no annotation 4 ILE A  49
PHE A 105
PRO A  59
PHE A  56
None
1.08A 5x23A-5nzbA:
undetectable
5x23A-5nzbA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udg NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE


(Bacillus
subtilis)
PF14489
(QueF)
4 ILE A  66
PHE A 122
THR A 134
PRO A 132
None
1.06A 5x23A-5udgA:
undetectable
5x23A-5udgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udg NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE


(Bacillus
subtilis)
PF14489
(QueF)
4 PHE A  51
PHE A 122
THR A 134
PRO A 132
None
1.09A 5x23A-5udgA:
undetectable
5x23A-5udgA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum)
no annotation 4 PHE A  61
PHE A  60
PRO A 418
PHE A 353
None
0.94A 5x23A-5v2dA:
undetectable
5x23A-5v2dA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Trypanosoma
brucei)
no annotation 4 ILE A 287
ASN A  42
THR A 370
PRO A 347
None
1.04A 5x23A-5x8oA:
undetectable
5x23A-5x8oA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A


(Leptotrichia
buccalis)
no annotation 4 PHE A 478
ILE A 487
PHE A 375
ASN A 372
None
1.01A 5x23A-5xwyA:
undetectable
5x23A-5xwyA:
17.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 8 PHE A  69
ILE A  74
PHE A 100
ASN A 218
PRO A 363
THR A 364
PRO A 367
PHE A 476
LSN  A 503 ( 4.8A)
LSN  A 503 (-4.7A)
LSN  A 503 (-4.1A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.6A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.1A)
LSN  A 503 (-3.8A)
0.36A 5x23A-5xxiA:
63.7
5x23A-5xxiA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3


(Armillaria
tabescens)
no annotation 4 ILE A 478
PHE A 358
THR A 474
PRO A 472
None
1.07A 5x23A-5yfbA:
undetectable
5x23A-5yfbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE


(Pseudomonas
aeruginosa)
no annotation 4 PHE A  93
ILE A  95
PHE A 152
PRO A 336
KCX  A 150 ( 4.0A)
None
KCX  A 150 ( 4.0A)
None
1.12A 5x23A-5ykdA:
undetectable
5x23A-5ykdA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-)
no annotation 4 ILE A 353
PHE A 411
ASN A 421
THR A 399
NAG  A1003 ( 4.4A)
None
None
None
1.17A 5x23A-5zicA:
undetectable
5x23A-5zicA:
undetectable