SIMILAR PATTERNS OF AMINO ACIDS FOR 5X23_A_LSNA502_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3c | PROTEIN(ADENYLOSUCCINATELYASE) (Thermotogamaritima) |
PF00206(Lyase_1)PF10397(ADSL_C) | 3 | LEU A 155VAL A 421ASP A 422 | None | 0.58A | 5x23A-1c3cA:0.0 | 5x23A-1c3cA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | LEU A 324VAL A 536ASP A 537 | None | 0.59A | 5x23A-1gpeA:0.0 | 5x23A-1gpeA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jn0 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEA (Spinaciaoleracea) |
no annotation | 3 | LEU O 25VAL O 322ASP O 323 | None | 0.66A | 5x23A-1jn0O:0.0 | 5x23A-1jn0O:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkr | 3-METHYLASPARTATEAMMONIA-LYASE (Citrobacteramalonaticus) |
PF05034(MAAL_N)PF07476(MAAL_C) | 3 | LEU A 160VAL A 342ASP A 343 | None | 0.66A | 5x23A-1kkrA:undetectable | 5x23A-1kkrA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llp | LIGNIN PEROXIDASE (Phanerochaetechrysosporium) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | LEU A 169VAL A 151ASP A 152 | None | 0.65A | 5x23A-1llpA:0.0 | 5x23A-1llpA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1np7 | DNA PHOTOLYASE (Synechocystissp. PCC 6803) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | LEU A 307VAL A 389ASP A 388 | None | 0.59A | 5x23A-1np7A:0.0 | 5x23A-1np7A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odo | PUTATIVE CYTOCHROMEP450 154A1 (Streptomycescoelicolor) |
PF00067(p450) | 3 | LEU A 405VAL A 126ASP A 127 | None | 0.66A | 5x23A-1odoA:29.5 | 5x23A-1odoA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 3 | LEU A 426VAL A 339ASP A 340 | None | 0.00A | 5x23A-1q5aA:undetectable | 5x23A-1q5aA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qf7 | PROTEIN (CATALASEHPII) (Escherichiacoli) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | LEU A 364VAL A 579ASP A 578 | None | 0.53A | 5x23A-1qf7A:0.0 | 5x23A-1qf7A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qrp | PEPSIN 3A (Homo sapiens) |
PF00026(Asp) | 3 | LEU E 6VAL E 30ASP E 32 | NoneHH0 E 327 ( 4.7A)HH0 E 327 (-2.7A) | 0.65A | 5x23A-1qrpE:undetectable | 5x23A-1qrpE:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 3 | LEU A 712VAL A 45ASP A 46 | None | 0.66A | 5x23A-1t6pA:undetectable | 5x23A-1t6pA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tq8 | HYPOTHETICAL PROTEINRV1636 (Mycobacteriumtuberculosis) |
PF00582(Usp) | 3 | LEU A 47VAL A 34ASP A 35 | None | 0.59A | 5x23A-1tq8A:undetectable | 5x23A-1tq8A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuz | DIACYLGLYCEROLKINASE ALPHA (Homo sapiens) |
PF14513(DAG_kinase_N) | 3 | LEU A 31VAL A 99ASP A 98 | None | 0.65A | 5x23A-1tuzA:undetectable | 5x23A-1tuzA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u83 | PHOSPHOSULFOLACTATESYNTHASE (Bacillussubtilis) |
PF02679(ComA) | 3 | LEU A 153VAL A 191ASP A 192 | None | 0.55A | 5x23A-1u83A:undetectable | 5x23A-1u83A:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wky | ENDO-BETA-1,4-MANNANASE (Bacillus sp.JAMB-602) |
PF00150(Cellulase) | 3 | LEU A 184VAL A 134ASP A 135 | None | 0.56A | 5x23A-1wkyA:undetectable | 5x23A-1wkyA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wm9 | GTP CYCLOHYDROLASE I (Thermusthermophilus) |
PF01227(GTP_cyclohydroI) | 3 | LEU A 152VAL A 139ASP A 140 | None | 0.64A | 5x23A-1wm9A:undetectable | 5x23A-1wm9A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xi3 | THIAMINE PHOSPHATEPYROPHOSPHORYLASE (Pyrococcusfuriosus) |
PF02581(TMP-TENI) | 3 | LEU A 146VAL A 157ASP A 177 | None | 0.64A | 5x23A-1xi3A:undetectable | 5x23A-1xi3A:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 3 | LEU A 735VAL A 762ASP A 763 | None | 0.52A | 5x23A-1ygpA:undetectable | 5x23A-1ygpA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvw | PHOSPHORIBOSYL-ATPPYROPHOSPHATASE (Bacillus cereus) |
PF01503(PRA-PH) | 3 | LEU A 8VAL A 64ASP A 65 | None | 0.59A | 5x23A-1yvwA:undetectable | 5x23A-1yvwA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ap9 | ACETYLGLUTAMATEKINASE (Mycobacteriumtuberculosis) |
PF00696(AA_kinase) | 3 | LEU A 100VAL A 189ASP A 185 | None | 0.62A | 5x23A-2ap9A:undetectable | 5x23A-2ap9A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fn4 | RAS-RELATED PROTEINR-RAS (Homo sapiens) |
PF00071(Ras) | 3 | LEU A 105VAL A 179ASP A 180 | None | 0.58A | 5x23A-2fn4A:undetectable | 5x23A-2fn4A:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g7l | TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 3 | LEU A 97VAL A 149ASP A 150 | None | 0.63A | 5x23A-2g7lA:undetectable | 5x23A-2g7lA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2guu | ODCASE (Plasmodiumvivax) |
PF00215(OMPdecase) | 3 | LEU A 188VAL A 147ASP A 148 | None | 0.57A | 5x23A-2guuA:undetectable | 5x23A-2guuA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6h | HYPOTHETICAL PROTEINATU0120 (Agrobacteriumfabrum) |
PF06041(DUF924) | 3 | LEU A 109VAL A 13ASP A 14 | None | 0.60A | 5x23A-2i6hA:undetectable | 5x23A-2i6hA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6t | UBIQUITIN-CONJUGATING ENZYME E2-LIKEISOFORM A (Homo sapiens) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | LEU A 306VAL A 270ASP A 271 | None | 0.61A | 5x23A-2i6tA:undetectable | 5x23A-2i6tA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jbm | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Homo sapiens) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 3 | LEU A 231VAL A 247ASP A 267 | None | 0.66A | 5x23A-2jbmA:undetectable | 5x23A-2jbmA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jh3 | RIBOSOMAL PROTEINS2-RELATED PROTEIN (Deinococcusradiodurans) |
PF01903(CbiX) | 3 | LEU A 455VAL A 412ASP A 413 | SF4 A 650 (-4.1A)NoneNone | 0.49A | 5x23A-2jh3A:undetectable | 5x23A-2jh3A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ox5 | SOXY PROTEIN (Paracoccusdenitrificans) |
no annotation | 3 | LEU Y 88VAL Y 3ASP Y 4 | None | 0.64A | 5x23A-2ox5Y:undetectable | 5x23A-2ox5Y:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq0 | HYPOTHETICALCONSERVED PROTEINGK1056 (Geobacilluskaustophilus) |
PF08282(Hydrolase_3) | 3 | LEU A 82VAL A 177ASP A 176 | None | 0.62A | 5x23A-2pq0A:undetectable | 5x23A-2pq0A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzp | ACYLAMINO-ACID-RELEASING ENZYME (Aeropyrumpernix) |
PF00326(Peptidase_S9) | 3 | LEU A 461VAL A 423ASP A 422 | None | 0.50A | 5x23A-2qzpA:undetectable | 5x23A-2qzpA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5j | MAJOR CAPSID PROTEINL1 (Alphapapillomavirus9) |
PF00500(Late_protein_L1) | 3 | LEU A 195VAL A 201ASP A 202 | None | 0.60A | 5x23A-2r5jA:undetectable | 5x23A-2r5jA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Staphylococcushaemolyticus) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 3 | LEU B 271VAL B 377ASP B 378 | None | 0.43A | 5x23A-2rhqB:undetectable | 5x23A-2rhqB:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsx | L-CARNITINE/GAMMA-BUTYROBETAINEANTIPORTER (Escherichiacoli) |
PF02028(BCCT) | 3 | LEU A 483VAL A 192ASP A 193 | None | 0.59A | 5x23A-2wsxA:undetectable | 5x23A-2wsxA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xe4 | OLIGOPEPTIDASE B (Leishmaniamajor) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 3 | LEU A 342VAL A 384ASP A 379 | GOL A1733 (-4.6A) CL A1798 ( 3.9A)PGR A1760 ( 4.3A) | 0.64A | 5x23A-2xe4A:undetectable | 5x23A-2xe4A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xt6 | 2-OXOGLUTARATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00198(2-oxoacid_dh)PF00676(E1_dh)PF02779(Transket_pyr)PF16870(OxoGdeHyase_C) | 3 | LEU A 530VAL A 725ASP A 726 | None | 0.61A | 5x23A-2xt6A:undetectable | 5x23A-2xt6A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y89 | PHOSPHORIBOSYLISOMERASE A (Mycobacteriumtuberculosis) |
PF00977(His_biosynth) | 3 | LEU A 74VAL A 35ASP A 36 | None | 0.65A | 5x23A-2y89A:undetectable | 5x23A-2y89A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ykf | PROBABLE SENSORHISTIDINE KINASEPDTAS (Mycobacteriumtuberculosis) |
PF12282(H_kinase_N) | 3 | LEU A 4VAL A 19ASP A 20 | None | 0.48A | 5x23A-2ykfA:undetectable | 5x23A-2ykfA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 3 | LEU A 272VAL A 229ASP A 230 | None | 0.61A | 5x23A-3afgA:undetectable | 5x23A-3afgA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3at7 | ALGINATE-BINDINGFLAGELLIN (Sphingomonassp. A1) |
PF09375(Peptidase_M75) | 3 | LEU A 260VAL A 218ASP A 219 | None | 0.55A | 5x23A-3at7A:undetectable | 5x23A-3at7A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b20 | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE(NADP+) (Synechococcuselongatus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | LEU A 29VAL A 327ASP A 328 | None | 0.65A | 5x23A-3b20A:undetectable | 5x23A-3b20A:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3by9 | SENSOR PROTEIN (Vibrio cholerae) |
PF02743(dCache_1) | 3 | LEU A 274VAL A 50ASP A 54 | None | 0.56A | 5x23A-3by9A:undetectable | 5x23A-3by9A:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3chx | PMOAPMOC (Methylosinustrichosporium) |
PF02461(AMO)PF04896(AmoC) | 3 | LEU C 101VAL B 23ASP B 27 | None | 0.62A | 5x23A-3chxC:undetectable | 5x23A-3chxC:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1r | FRUCTOSE-1,6-BISPHOSPHATASE CLASS IIGLPX (Escherichiacoli) |
PF03320(FBPase_glpX) | 3 | LEU A 101VAL A 189ASP A 188 | NoneNoneFBP A3499 (-2.8A) | 0.58A | 5x23A-3d1rA:undetectable | 5x23A-3d1rA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbg | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 3 | LEU A 245VAL A 227ASP A 228 | None | 0.56A | 5x23A-3dbgA:33.3 | 5x23A-3dbgA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | LEU A 730VAL A 687ASP A 689 | None | 0.62A | 5x23A-3f2bA:undetectable | 5x23A-3f2bA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpz | THIAZOLEBIOSYNTHETIC ENZYME (Saccharomycescerevisiae) |
PF01946(Thi4) | 3 | LEU A 296VAL A 250ASP A 253 | None | 0.62A | 5x23A-3fpzA:undetectable | 5x23A-3fpzA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNITA' (Sulfolobussolfataricus) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 3 | LEU A 696VAL A 672ASP A 673 | None | 0.56A | 5x23A-3hkzA:undetectable | 5x23A-3hkzA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hxg | EUKARYOTICTRANSLATIONINITIATION FACTOR 4E (Schistosomamansoni) |
PF01652(IF4E) | 3 | LEU A 149VAL A 110ASP A 111 | None | 0.65A | 5x23A-3hxgA:undetectable | 5x23A-3hxgA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 3 | LEU A 123VAL A 84ASP A 85 | None | 0.65A | 5x23A-3iuuA:undetectable | 5x23A-3iuuA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivu | HOMOCITRATESYNTHASE,MITOCHONDRIAL (Schizosaccharomycespombe) |
PF00682(HMGL-like) | 3 | LEU A 377VAL A 395ASP A 396 | None | 0.56A | 5x23A-3ivuA:undetectable | 5x23A-3ivuA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qm1 | CINNAMOYL ESTERASE (Lactobacillusjohnsonii) |
PF12146(Hydrolase_4) | 3 | LEU A 6VAL A 91ASP A 94 | None | 0.64A | 5x23A-3qm1A:undetectable | 5x23A-3qm1A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tts | BETA-GALACTOSIDASE (Bacilluscirculans) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 3 | LEU A 347VAL A 39ASP A 38 | None | 0.62A | 5x23A-3ttsA:undetectable | 5x23A-3ttsA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uzu | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE A (Burkholderiapseudomallei) |
PF00398(RrnaAD) | 3 | LEU A 214VAL A 258ASP A 259 | None | 0.62A | 5x23A-3uzuA:undetectable | 5x23A-3uzuA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3voc | BETA/ALPHA-AMYLASE (Paenibacilluspolymyxa) |
PF01373(Glyco_hydro_14) | 3 | LEU A 356VAL A 342ASP A 343 | NoneNoneTRS A 509 ( 3.0A) | 0.45A | 5x23A-3vocA:undetectable | 5x23A-3vocA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vps | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Streptomyceschartreusis) |
PF01370(Epimerase) | 3 | LEU A 27VAL A 217ASP A 218 | None | 0.64A | 5x23A-3vpsA:undetectable | 5x23A-3vpsA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zhr | MULTIFUNCTIONAL2-OXOGLUTARATEMETABOLISM ENZYME (Mycolicibacteriumsmegmatis) |
PF00676(E1_dh)PF02779(Transket_pyr)PF16870(OxoGdeHyase_C) | 3 | LEU A 530VAL A 725ASP A 726 | None | 0.60A | 5x23A-3zhrA:undetectable | 5x23A-3zhrA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aio | LIMIT DEXTRINASE (Hordeum vulgare) |
PF02922(CBM_48)PF11852(DUF3372) | 3 | LEU A 490VAL A 455ASP A 456 | None | 0.55A | 5x23A-4aioA:undetectable | 5x23A-4aioA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aio | LIMIT DEXTRINASE (Hordeum vulgare) |
PF02922(CBM_48)PF11852(DUF3372) | 3 | LEU A 690VAL A 660ASP A 661 | None | 0.66A | 5x23A-4aioA:undetectable | 5x23A-4aioA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX ALPHA-CHAINFADB (Mycobacteriumtuberculosis) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 3 | LEU A 101VAL A 42ASP A 43 | None | 0.59A | 5x23A-4b3iA:undetectable | 5x23A-4b3iA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cze | RODSHAPE-DETERMININGPROTEIN MREB (Caulobactervibrioides) |
PF06723(MreB_Mbl) | 3 | LEU A 205VAL A 235ASP A 234 | None | 0.63A | 5x23A-4czeA:undetectable | 5x23A-4czeA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dlk | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Bacillusanthracis) |
PF02222(ATP-grasp)PF02826(2-Hacid_dh_C) | 3 | LEU A 133VAL A 167ASP A 168 | LEU A 133 ( 0.6A)VAL A 167 ( 0.6A)ASP A 168 ( 0.6A) | 0.64A | 5x23A-4dlkA:undetectable | 5x23A-4dlkA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fys | AMINOPEPTIDASE N (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 3 | LEU A 80VAL A 119ASP A 118 | None | 0.53A | 5x23A-4fysA:undetectable | 5x23A-4fysA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g0b | HYDROXYCINNAMOYL-COASHIKIMATE/QUINATEHYDROXYCINNAMOYLTRANSFERASE (Coffeacanephora) |
PF02458(Transferase) | 3 | LEU A 92VAL A 121ASP A 122 | None | 0.65A | 5x23A-4g0bA:undetectable | 5x23A-4g0bA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gtr | PROTEINFARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNITALPHA (Rattusnorvegicus) |
PF01239(PPTA) | 3 | LEU A 363VAL A 316ASP A 317 | None | 0.53A | 5x23A-4gtrA:undetectable | 5x23A-4gtrA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3w | HYPOTHETICAL PROTEIN (Parabacteroidesdistasonis) |
PF15414(DUF4621) | 3 | LEU A 332VAL A 54ASP A 53 | MLY A 333 ( 3.7A)NoneNone | 0.66A | 5x23A-4h3wA:undetectable | 5x23A-4h3wA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpv | S-ADENOSYLMETHIONINESYNTHASE (Sulfolobussolfataricus) |
PF01941(AdoMet_Synthase) | 3 | LEU A 323VAL A 382ASP A 383 | None | 0.65A | 5x23A-4hpvA:undetectable | 5x23A-4hpvA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i62 | AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDINGPROTEIN, PUTATIVE (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 3 | LEU A 70VAL A 241ASP A 242 | None | 0.53A | 5x23A-4i62A:undetectable | 5x23A-4i62A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9a | QUINOLINATEPHOSPHORIBOSYLTRANSFERASE (Sus scrofa) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 3 | LEU A 229VAL A 245ASP A 265 | None | 0.62A | 5x23A-4i9aA:undetectable | 5x23A-4i9aA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4in0 | THIOREDOXIN-LIKEPROTEIN 4B (Homo sapiens) |
PF02966(DIM1) | 3 | LEU A 26VAL A 14ASP A 15 | None | 0.58A | 5x23A-4in0A:undetectable | 5x23A-4in0A:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ixu | ARGINASE-2,MITOCHONDRIAL (Homo sapiens) |
PF00491(Arginase) | 3 | LEU A 58VAL A 316ASP A 317 | BME A 404 (-4.6A)NoneNone | 0.62A | 5x23A-4ixuA:undetectable | 5x23A-4ixuA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k12 | CHOLINE BINDINGPROTEIN A (Streptococcuspneumoniae) |
PF05062(RICH) | 3 | LEU B 38VAL B 73ASP B 74 | None | 0.49A | 5x23A-4k12B:undetectable | 5x23A-4k12B:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l1k | D-ALANINE--D-ALANINELIGASE (Xanthomonasoryzae) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 3 | LEU A 182VAL A 171ASP A 172 | None | 0.45A | 5x23A-4l1kA:undetectable | 5x23A-4l1kA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l68 | LEUCINE-RICH REPEATPROTEIN KINASE-LIKEPROTEIN (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 3 | LEU A 555VAL A 518ASP A 519 | None | 0.56A | 5x23A-4l68A:undetectable | 5x23A-4l68A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n7r | GLUTAMYL-TRNAREDUCTASE 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00745(GlutR_dimer)PF01488(Shikimate_DH)PF05201(GlutR_N) | 3 | LEU A 204VAL A 401ASP A 402 | None | 0.65A | 5x23A-4n7rA:undetectable | 5x23A-4n7rA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ogc | HNH ENDONUCLEASEDOMAIN PROTEIN (Actinomycesnaeslundii) |
PF01844(HNH) | 3 | LEU A 797VAL A 738ASP A 739 | NoneNone MN A1206 (-4.6A) | 0.59A | 5x23A-4ogcA:undetectable | 5x23A-4ogcA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4po0 | SERUM ALBUMIN (Oryctolaguscuniculus) |
PF00273(Serum_albumin) | 3 | LEU A 446VAL A 381ASP A 382 | None | 0.65A | 5x23A-4po0A:undetectable | 5x23A-4po0A:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0m | L-ASPARAGINASE (Pyrococcusfuriosus) |
PF00710(Asparaginase) | 3 | LEU A 194VAL A 61ASP A 62 | 4CS A 405 (-4.9A)NoneNone | 0.56A | 5x23A-4q0mA:undetectable | 5x23A-4q0mA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q62 | LEUCINE-RICHREPEAT-AND COILEDCOIL-CONTAININGPROTEIN (Legionellapneumophila) |
PF13855(LRR_8) | 3 | LEU A 207VAL A 176ASP A 177 | None | 0.58A | 5x23A-4q62A:undetectable | 5x23A-4q62A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ql6 | CARBOXY-TERMINALPROCESSING PROTEASE (Chlamydiatrachomatis) |
PF00595(PDZ)PF03572(Peptidase_S41) | 3 | LEU A 228VAL A 34ASP A 35 | None | 0.58A | 5x23A-4ql6A:undetectable | 5x23A-4ql6A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtu | PUTATIVEMETHYLTRANSFERASEBUD23 (Saccharomycescerevisiae) |
PF08241(Methyltransf_11) | 3 | LEU B 197VAL B 166ASP B 167 | None | 0.56A | 5x23A-4qtuB:undetectable | 5x23A-4qtuB:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r42 | ALR3090 PROTEIN (Nostoc sp. PCC7120) |
PF05067(Mn_catalase) | 3 | LEU A 174VAL A 122ASP A 121 | None | 0.66A | 5x23A-4r42A:undetectable | 5x23A-4r42A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rya | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (SORBITOL) (Agrobacteriumvitis) |
PF01547(SBP_bac_1) | 3 | LEU A 59VAL A 68ASP A 71 | None | 0.55A | 5x23A-4ryaA:undetectable | 5x23A-4ryaA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvr | E3 UBIQUITIN-PROTEINLIGASE UHRF2 (Homo sapiens) |
PF00628(PHD)PF12148(TTD) | 3 | LEU A 242VAL A 302ASP A 303 | NoneUNX A 409 ( 4.5A)UNX A 409 ( 3.6A) | 0.58A | 5x23A-4tvrA:undetectable | 5x23A-4tvrA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x28 | ACYL-COADEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 3 | LEU D 43VAL D 16ASP D 17 | None | 0.51A | 5x23A-4x28D:undetectable | 5x23A-4x28D:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9l | PROTEIN ACDH-11,ISOFORM B (Caenorhabditiselegans) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 3 | LEU A 558VAL A 381ASP A 382 | None | 0.63A | 5x23A-4y9lA:undetectable | 5x23A-4y9lA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynu | GLUCOSE OXIDASE,PUTATIVE (Aspergillusflavus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 3 | LEU A 306VAL A 521ASP A 522 | None | 0.55A | 5x23A-4ynuA:undetectable | 5x23A-4ynuA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z11 | AURONE SYNTHASE (Coreopsisgrandiflora) |
PF00264(Tyrosinase)PF12142(PPO1_DWL)PF12143(PPO1_KFDV) | 3 | LEU A 172VAL A 65ASP A 66 | None | 0.47A | 5x23A-4z11A:undetectable | 5x23A-4z11A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z17 | ENOLASE (Chloroflexusaurantiacus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 3 | LEU A 304VAL A 270ASP A 271 | None | 0.65A | 5x23A-4z17A:undetectable | 5x23A-4z17A:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7t | TRNA(ADENINE(9)-N1)-METHYLTRANSFERASE (Sulfolobusacidocaldarius) |
no annotation | 3 | LEU A 128VAL A 112ASP A 113 | None | 0.51A | 5x23A-5a7tA:undetectable | 5x23A-5a7tA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7y | TRNA(ADENINE(9)-N1)-METHYLTRANSFERASE (Sulfolobusacidocaldarius) |
no annotation | 3 | LEU A 128VAL A 112ASP A 113 | None | 0.55A | 5x23A-5a7yA:undetectable | 5x23A-5a7yA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp8 | ENT-COPALYLDIPHOSPHATE SYNTHASE (Streptomycesplatensis) |
PF00432(Prenyltrans)PF13243(SQHop_cyclase_C) | 3 | LEU A 463VAL A 430ASP A 431 | None | 0.59A | 5x23A-5bp8A:undetectable | 5x23A-5bp8A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c7i | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE,TESTIS-SPECIFIC (Mus musculus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | LEU O 108VAL O 429ASP O 430 | None | 0.59A | 5x23A-5c7iO:undetectable | 5x23A-5c7iO:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c7o | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE,TESTIS-SPECIFIC (Homo sapiens) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | LEU O 76VAL O 397ASP O 398 | None | 0.55A | 5x23A-5c7oO:undetectable | 5x23A-5c7oO:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dds | CRMG (Actinoalloteichussp. WH1-2216-6) |
PF00202(Aminotran_3) | 3 | LEU A 259VAL A 179ASP A 180 | None | 0.52A | 5x23A-5ddsA:undetectable | 5x23A-5ddsA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dot | CARBAMOYL-PHOSPHATESYNTHASE [AMMONIA],MITOCHONDRIAL (Homo sapiens) |
PF00117(GATase)PF00988(CPSase_sm_chain)PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 3 | LEU A 433VAL A1457ASP A1458 | None | 0.59A | 5x23A-5dotA:undetectable | 5x23A-5dotA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e78 | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00067(p450) | 3 | LEU A 234VAL A 216ASP A 217 | None | 0.30A | 5x23A-5e78A:35.1 | 5x23A-5e78A:28.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyt | ADENYLOSUCCINATELYASE (Schistosomamansoni) |
PF00206(Lyase_1)PF10397(ADSL_C) | 3 | LEU A 183VAL A 242ASP A 243 | None | 0.52A | 5x23A-5eytA:undetectable | 5x23A-5eytA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmq | INFLUENZA A PB2SUBUNIT (Influenza Avirus) |
PF00604(Flu_PB2) | 3 | LEU A 317VAL A 295ASP A 296 | None | 0.65A | 5x23A-5fmqA:undetectable | 5x23A-5fmqA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ft6 | CYSTEINE DESULFURASECSDA (Escherichiacoli) |
PF00266(Aminotran_5) | 3 | LEU A 312VAL A 385ASP A 386 | None | 0.61A | 5x23A-5ft6A:undetectable | 5x23A-5ft6A:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw5 | T-COMPLEX PROTEIN 1SUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 3 | LEU a 413VAL a 181ASP a 182 | None | 0.66A | 5x23A-5gw5a:undetectable | 5x23A-5gw5a:21.05 |