SIMILAR PATTERNS OF AMINO ACIDS FOR 5X23_A_LSNA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)


(Thermotoga
maritima)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
3 LEU A 155
VAL A 421
ASP A 422
None
0.58A 5x23A-1c3cA:
0.0
5x23A-1c3cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)


(Penicillium
amagasakiense)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 LEU A 324
VAL A 536
ASP A 537
None
0.59A 5x23A-1gpeA:
0.0
5x23A-1gpeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A


(Spinacia
oleracea)
no annotation 3 LEU O  25
VAL O 322
ASP O 323
None
0.66A 5x23A-1jn0O:
0.0
5x23A-1jn0O:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE


(Citrobacter
amalonaticus)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
3 LEU A 160
VAL A 342
ASP A 343
None
0.66A 5x23A-1kkrA:
undetectable
5x23A-1kkrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
3 LEU A 169
VAL A 151
ASP A 152
None
0.65A 5x23A-1llpA:
0.0
5x23A-1llpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 LEU A 307
VAL A 389
ASP A 388
None
0.59A 5x23A-1np7A:
0.0
5x23A-1np7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1


(Streptomyces
coelicolor)
PF00067
(p450)
3 LEU A 405
VAL A 126
ASP A 127
None
0.66A 5x23A-1odoA:
29.5
5x23A-1odoA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 LEU A 426
VAL A 339
ASP A 340
None
0.00A 5x23A-1q5aA:
undetectable
5x23A-1q5aA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)


(Escherichia
coli)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 LEU A 364
VAL A 579
ASP A 578
None
0.53A 5x23A-1qf7A:
0.0
5x23A-1qf7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens)
PF00026
(Asp)
3 LEU E   6
VAL E  30
ASP E  32
None
HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
0.65A 5x23A-1qrpE:
undetectable
5x23A-1qrpE:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
3 LEU A 712
VAL A  45
ASP A  46
None
0.66A 5x23A-1t6pA:
undetectable
5x23A-1t6pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq8 HYPOTHETICAL PROTEIN
RV1636


(Mycobacterium
tuberculosis)
PF00582
(Usp)
3 LEU A  47
VAL A  34
ASP A  35
None
0.59A 5x23A-1tq8A:
undetectable
5x23A-1tq8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuz DIACYLGLYCEROL
KINASE ALPHA


(Homo sapiens)
PF14513
(DAG_kinase_N)
3 LEU A  31
VAL A  99
ASP A  98
None
0.65A 5x23A-1tuzA:
undetectable
5x23A-1tuzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u83 PHOSPHOSULFOLACTATE
SYNTHASE


(Bacillus
subtilis)
PF02679
(ComA)
3 LEU A 153
VAL A 191
ASP A 192
None
0.55A 5x23A-1u83A:
undetectable
5x23A-1u83A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE


(Bacillus sp.
JAMB-602)
PF00150
(Cellulase)
3 LEU A 184
VAL A 134
ASP A 135
None
0.56A 5x23A-1wkyA:
undetectable
5x23A-1wkyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wm9 GTP CYCLOHYDROLASE I

(Thermus
thermophilus)
PF01227
(GTP_cyclohydroI)
3 LEU A 152
VAL A 139
ASP A 140
None
0.64A 5x23A-1wm9A:
undetectable
5x23A-1wm9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi3 THIAMINE PHOSPHATE
PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF02581
(TMP-TENI)
3 LEU A 146
VAL A 157
ASP A 177
None
0.64A 5x23A-1xi3A:
undetectable
5x23A-1xi3A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
3 LEU A 735
VAL A 762
ASP A 763
None
0.52A 5x23A-1ygpA:
undetectable
5x23A-1ygpA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvw PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE


(Bacillus cereus)
PF01503
(PRA-PH)
3 LEU A   8
VAL A  64
ASP A  65
None
0.59A 5x23A-1yvwA:
undetectable
5x23A-1yvwA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap9 ACETYLGLUTAMATE
KINASE


(Mycobacterium
tuberculosis)
PF00696
(AA_kinase)
3 LEU A 100
VAL A 189
ASP A 185
None
0.62A 5x23A-2ap9A:
undetectable
5x23A-2ap9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn4 RAS-RELATED PROTEIN
R-RAS


(Homo sapiens)
PF00071
(Ras)
3 LEU A 105
VAL A 179
ASP A 180
None
0.58A 5x23A-2fn4A:
undetectable
5x23A-2fn4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
3 LEU A  97
VAL A 149
ASP A 150
None
0.63A 5x23A-2g7lA:
undetectable
5x23A-2g7lA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax)
PF00215
(OMPdecase)
3 LEU A 188
VAL A 147
ASP A 148
None
0.57A 5x23A-2guuA:
undetectable
5x23A-2guuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6h HYPOTHETICAL PROTEIN
ATU0120


(Agrobacterium
fabrum)
PF06041
(DUF924)
3 LEU A 109
VAL A  13
ASP A  14
None
0.60A 5x23A-2i6hA:
undetectable
5x23A-2i6hA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A


(Homo sapiens)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
3 LEU A 306
VAL A 270
ASP A 271
None
0.61A 5x23A-2i6tA:
undetectable
5x23A-2i6tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Homo sapiens)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
3 LEU A 231
VAL A 247
ASP A 267
None
0.66A 5x23A-2jbmA:
undetectable
5x23A-2jbmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN


(Deinococcus
radiodurans)
PF01903
(CbiX)
3 LEU A 455
VAL A 412
ASP A 413
SF4  A 650 (-4.1A)
None
None
0.49A 5x23A-2jh3A:
undetectable
5x23A-2jh3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox5 SOXY PROTEIN

(Paracoccus
denitrificans)
no annotation 3 LEU Y  88
VAL Y   3
ASP Y   4
None
0.64A 5x23A-2ox5Y:
undetectable
5x23A-2ox5Y:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056


(Geobacillus
kaustophilus)
PF08282
(Hydrolase_3)
3 LEU A  82
VAL A 177
ASP A 176
None
0.62A 5x23A-2pq0A:
undetectable
5x23A-2pq0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME


(Aeropyrum
pernix)
PF00326
(Peptidase_S9)
3 LEU A 461
VAL A 423
ASP A 422
None
0.50A 5x23A-2qzpA:
undetectable
5x23A-2qzpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1


(Alphapapillomavirus
9)
PF00500
(Late_protein_L1)
3 LEU A 195
VAL A 201
ASP A 202
None
0.60A 5x23A-2r5jA:
undetectable
5x23A-2r5jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Staphylococcus
haemolyticus)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
3 LEU B 271
VAL B 377
ASP B 378
None
0.43A 5x23A-2rhqB:
undetectable
5x23A-2rhqB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER


(Escherichia
coli)
PF02028
(BCCT)
3 LEU A 483
VAL A 192
ASP A 193
None
0.59A 5x23A-2wsxA:
undetectable
5x23A-2wsxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
3 LEU A 342
VAL A 384
ASP A 379
GOL  A1733 (-4.6A)
CL  A1798 ( 3.9A)
PGR  A1760 ( 4.3A)
0.64A 5x23A-2xe4A:
undetectable
5x23A-2xe4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE


(Mycolicibacterium
smegmatis)
PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C)
3 LEU A 530
VAL A 725
ASP A 726
None
0.61A 5x23A-2xt6A:
undetectable
5x23A-2xt6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A


(Mycobacterium
tuberculosis)
PF00977
(His_biosynth)
3 LEU A  74
VAL A  35
ASP A  36
None
0.65A 5x23A-2y89A:
undetectable
5x23A-2y89A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS


(Mycobacterium
tuberculosis)
PF12282
(H_kinase_N)
3 LEU A   4
VAL A  19
ASP A  20
None
0.48A 5x23A-2ykfA:
undetectable
5x23A-2ykfA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
3 LEU A 272
VAL A 229
ASP A 230
None
0.61A 5x23A-3afgA:
undetectable
5x23A-3afgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN


(Sphingomonas
sp. A1)
PF09375
(Peptidase_M75)
3 LEU A 260
VAL A 218
ASP A 219
None
0.55A 5x23A-3at7A:
undetectable
5x23A-3at7A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)


(Synechococcus
elongatus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
3 LEU A  29
VAL A 327
ASP A 328
None
0.65A 5x23A-3b20A:
undetectable
5x23A-3b20A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae)
PF02743
(dCache_1)
3 LEU A 274
VAL A  50
ASP A  54
None
0.56A 5x23A-3by9A:
undetectable
5x23A-3by9A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOC


(Methylosinus
trichosporium)
PF02461
(AMO)
PF04896
(AmoC)
3 LEU C 101
VAL B  23
ASP B  27
None
0.62A 5x23A-3chxC:
undetectable
5x23A-3chxC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX


(Escherichia
coli)
PF03320
(FBPase_glpX)
3 LEU A 101
VAL A 189
ASP A 188
None
None
FBP  A3499 (-2.8A)
0.58A 5x23A-3d1rA:
undetectable
5x23A-3d1rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450


(Streptomyces
coelicolor)
PF00067
(p450)
3 LEU A 245
VAL A 227
ASP A 228
None
0.56A 5x23A-3dbgA:
33.3
5x23A-3dbgA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN


(Geobacillus
kaustophilus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
3 LEU A 730
VAL A 687
ASP A 689
None
0.62A 5x23A-3f2bA:
undetectable
5x23A-3f2bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME


(Saccharomyces
cerevisiae)
PF01946
(Thi4)
3 LEU A 296
VAL A 250
ASP A 253
None
0.62A 5x23A-3fpzA:
undetectable
5x23A-3fpzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'


(Sulfolobus
solfataricus)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
3 LEU A 696
VAL A 672
ASP A 673
None
0.56A 5x23A-3hkzA:
undetectable
5x23A-3hkzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E


(Schistosoma
mansoni)
PF01652
(IF4E)
3 LEU A 149
VAL A 110
ASP A 111
None
0.65A 5x23A-3hxgA:
undetectable
5x23A-3hxgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE


(Chelativorans
sp. BNC1)
PF07171
(MlrC_C)
PF07364
(DUF1485)
3 LEU A 123
VAL A  84
ASP A  85
None
0.65A 5x23A-3iuuA:
undetectable
5x23A-3iuuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL


(Schizosaccharomyces
pombe)
PF00682
(HMGL-like)
3 LEU A 377
VAL A 395
ASP A 396
None
0.56A 5x23A-3ivuA:
undetectable
5x23A-3ivuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii)
PF12146
(Hydrolase_4)
3 LEU A   6
VAL A  91
ASP A  94
None
0.64A 5x23A-3qm1A:
undetectable
5x23A-3qm1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
3 LEU A 347
VAL A  39
ASP A  38
None
0.62A 5x23A-3ttsA:
undetectable
5x23A-3ttsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Burkholderia
pseudomallei)
PF00398
(RrnaAD)
3 LEU A 214
VAL A 258
ASP A 259
None
0.62A 5x23A-3uzuA:
undetectable
5x23A-3uzuA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa)
PF01373
(Glyco_hydro_14)
3 LEU A 356
VAL A 342
ASP A 343
None
None
TRS  A 509 ( 3.0A)
0.45A 5x23A-3vocA:
undetectable
5x23A-3vocA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Streptomyces
chartreusis)
PF01370
(Epimerase)
3 LEU A  27
VAL A 217
ASP A 218
None
0.64A 5x23A-3vpsA:
undetectable
5x23A-3vpsA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME


(Mycolicibacterium
smegmatis)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C)
3 LEU A 530
VAL A 725
ASP A 726
None
0.60A 5x23A-3zhrA:
undetectable
5x23A-3zhrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
3 LEU A 490
VAL A 455
ASP A 456
None
0.55A 5x23A-4aioA:
undetectable
5x23A-4aioA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
3 LEU A 690
VAL A 660
ASP A 661
None
0.66A 5x23A-4aioA:
undetectable
5x23A-4aioA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
3 LEU A 101
VAL A  42
ASP A  43
None
0.59A 5x23A-4b3iA:
undetectable
5x23A-4b3iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB


(Caulobacter
vibrioides)
PF06723
(MreB_Mbl)
3 LEU A 205
VAL A 235
ASP A 234
None
0.63A 5x23A-4czeA:
undetectable
5x23A-4czeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT


(Bacillus
anthracis)
PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C)
3 LEU A 133
VAL A 167
ASP A 168
LEU  A 133 ( 0.6A)
VAL  A 167 ( 0.6A)
ASP  A 168 ( 0.6A)
0.64A 5x23A-4dlkA:
undetectable
5x23A-4dlkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
3 LEU A  80
VAL A 119
ASP A 118
None
0.53A 5x23A-4fysA:
undetectable
5x23A-4fysA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE


(Coffea
canephora)
PF02458
(Transferase)
3 LEU A  92
VAL A 121
ASP A 122
None
0.65A 5x23A-4g0bA:
undetectable
5x23A-4g0bA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA


(Rattus
norvegicus)
PF01239
(PPTA)
3 LEU A 363
VAL A 316
ASP A 317
None
0.53A 5x23A-4gtrA:
undetectable
5x23A-4gtrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF15414
(DUF4621)
3 LEU A 332
VAL A  54
ASP A  53
MLY  A 333 ( 3.7A)
None
None
0.66A 5x23A-4h3wA:
undetectable
5x23A-4h3wA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE


(Sulfolobus
solfataricus)
PF01941
(AdoMet_Synthase)
3 LEU A 323
VAL A 382
ASP A 383
None
0.65A 5x23A-4hpvA:
undetectable
5x23A-4hpvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE


(Streptococcus
pneumoniae)
PF00497
(SBP_bac_3)
3 LEU A  70
VAL A 241
ASP A 242
None
0.53A 5x23A-4i62A:
undetectable
5x23A-4i62A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Sus scrofa)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
3 LEU A 229
VAL A 245
ASP A 265
None
0.62A 5x23A-4i9aA:
undetectable
5x23A-4i9aA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in0 THIOREDOXIN-LIKE
PROTEIN 4B


(Homo sapiens)
PF02966
(DIM1)
3 LEU A  26
VAL A  14
ASP A  15
None
0.58A 5x23A-4in0A:
undetectable
5x23A-4in0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL


(Homo sapiens)
PF00491
(Arginase)
3 LEU A  58
VAL A 316
ASP A 317
BME  A 404 (-4.6A)
None
None
0.62A 5x23A-4ixuA:
undetectable
5x23A-4ixuA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k12 CHOLINE BINDING
PROTEIN A


(Streptococcus
pneumoniae)
PF05062
(RICH)
3 LEU B  38
VAL B  73
ASP B  74
None
0.49A 5x23A-4k12B:
undetectable
5x23A-4k12B:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE


(Xanthomonas
oryzae)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
3 LEU A 182
VAL A 171
ASP A 172
None
0.45A 5x23A-4l1kA:
undetectable
5x23A-4l1kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
3 LEU A 555
VAL A 518
ASP A 519
None
0.56A 5x23A-4l68A:
undetectable
5x23A-4l68A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N)
3 LEU A 204
VAL A 401
ASP A 402
None
0.65A 5x23A-4n7rA:
undetectable
5x23A-4n7rA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN


(Actinomyces
naeslundii)
PF01844
(HNH)
3 LEU A 797
VAL A 738
ASP A 739
None
None
MN  A1206 (-4.6A)
0.59A 5x23A-4ogcA:
undetectable
5x23A-4ogcA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
3 LEU A 446
VAL A 381
ASP A 382
None
0.65A 5x23A-4po0A:
undetectable
5x23A-4po0A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus)
PF00710
(Asparaginase)
3 LEU A 194
VAL A  61
ASP A  62
4CS  A 405 (-4.9A)
None
None
0.56A 5x23A-4q0mA:
undetectable
5x23A-4q0mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN


(Legionella
pneumophila)
PF13855
(LRR_8)
3 LEU A 207
VAL A 176
ASP A 177
None
0.58A 5x23A-4q62A:
undetectable
5x23A-4q62A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE


(Chlamydia
trachomatis)
PF00595
(PDZ)
PF03572
(Peptidase_S41)
3 LEU A 228
VAL A  34
ASP A  35
None
0.58A 5x23A-4ql6A:
undetectable
5x23A-4ql6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23


(Saccharomyces
cerevisiae)
PF08241
(Methyltransf_11)
3 LEU B 197
VAL B 166
ASP B 167
None
0.56A 5x23A-4qtuB:
undetectable
5x23A-4qtuB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120)
PF05067
(Mn_catalase)
3 LEU A 174
VAL A 122
ASP A 121
None
0.66A 5x23A-4r42A:
undetectable
5x23A-4r42A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)


(Agrobacterium
vitis)
PF01547
(SBP_bac_1)
3 LEU A  59
VAL A  68
ASP A  71
None
0.55A 5x23A-4ryaA:
undetectable
5x23A-4ryaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2


(Homo sapiens)
PF00628
(PHD)
PF12148
(TTD)
3 LEU A 242
VAL A 302
ASP A 303
None
UNX  A 409 ( 4.5A)
UNX  A 409 ( 3.6A)
0.58A 5x23A-4tvrA:
undetectable
5x23A-4tvrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE


(Mycobacterium
tuberculosis)
no annotation 3 LEU D  43
VAL D  16
ASP D  17
None
0.51A 5x23A-4x28D:
undetectable
5x23A-4x28D:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B


(Caenorhabditis
elegans)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
3 LEU A 558
VAL A 381
ASP A 382
None
0.63A 5x23A-4y9lA:
undetectable
5x23A-4y9lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE


(Aspergillus
flavus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 LEU A 306
VAL A 521
ASP A 522
None
0.55A 5x23A-4ynuA:
undetectable
5x23A-4ynuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV)
3 LEU A 172
VAL A  65
ASP A  66
None
0.47A 5x23A-4z11A:
undetectable
5x23A-4z11A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
3 LEU A 304
VAL A 270
ASP A 271
None
0.65A 5x23A-4z17A:
undetectable
5x23A-4z17A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE


(Sulfolobus
acidocaldarius)
no annotation 3 LEU A 128
VAL A 112
ASP A 113
None
0.51A 5x23A-5a7tA:
undetectable
5x23A-5a7tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE


(Sulfolobus
acidocaldarius)
no annotation 3 LEU A 128
VAL A 112
ASP A 113
None
0.55A 5x23A-5a7yA:
undetectable
5x23A-5a7yA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE


(Streptomyces
platensis)
PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C)
3 LEU A 463
VAL A 430
ASP A 431
None
0.59A 5x23A-5bp8A:
undetectable
5x23A-5bp8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC


(Mus musculus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
3 LEU O 108
VAL O 429
ASP O 430
None
0.59A 5x23A-5c7iO:
undetectable
5x23A-5c7iO:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC


(Homo sapiens)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
3 LEU O  76
VAL O 397
ASP O 398
None
0.55A 5x23A-5c7oO:
undetectable
5x23A-5c7oO:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6)
PF00202
(Aminotran_3)
3 LEU A 259
VAL A 179
ASP A 180
None
0.52A 5x23A-5ddsA:
undetectable
5x23A-5ddsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL


(Homo sapiens)
PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3)
3 LEU A 433
VAL A1457
ASP A1458
None
0.59A 5x23A-5dotA:
undetectable
5x23A-5dotA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
3 LEU A 234
VAL A 216
ASP A 217
None
0.30A 5x23A-5e78A:
35.1
5x23A-5e78A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE


(Schistosoma
mansoni)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
3 LEU A 183
VAL A 242
ASP A 243
None
0.52A 5x23A-5eytA:
undetectable
5x23A-5eytA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT


(Influenza A
virus)
PF00604
(Flu_PB2)
3 LEU A 317
VAL A 295
ASP A 296
None
0.65A 5x23A-5fmqA:
undetectable
5x23A-5fmqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA


(Escherichia
coli)
PF00266
(Aminotran_5)
3 LEU A 312
VAL A 385
ASP A 386
None
0.61A 5x23A-5ft6A:
undetectable
5x23A-5ft6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
3 LEU a 413
VAL a 181
ASP a 182
None
0.66A 5x23A-5gw5a:
undetectable
5x23A-5gw5a:
21.05