SIMILAR PATTERNS OF AMINO ACIDS FOR 5X23_A_LSNA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ALA C 236
VAL C 520
GLY C 416
LEU C 356
LEU C 294
 None
 0.88A 5x23A-1a5lC:
0.0		 5x23A-1a5lC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 VAL A  89
PHE A  53
LEU A  79
GLY A 130
ALA A 131
 None
 1.46A 5x23A-1bhwA:
0.0		 5x23A-1bhwA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		5 ALA A  81
VAL A  97
GLY A  74
LEU A 242
LEU A 247
 None
 1.32A 5x23A-1bwzA:
0.0		 5x23A-1bwzA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 VAL A 104
ASN A 126
GLY A  62
ALA A  61
LEU A 110
 None
 1.28A 5x23A-1bxnA:
0.0		 5x23A-1bxnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 PHE A  55
MET A 125
ALA A 149
LEU A 189
LEU A 187
 None
 1.21A 5x23A-1ciaA:
0.0		 5x23A-1ciaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dle COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  66
GLY A  44
ALA A  31
LEU A 112
LEU A 108
 None
 1.08A 5x23A-1dleA:
0.0		 5x23A-1dleA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4y ADENYLATE KINASE

(Escherichia
coli) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 VAL A 196
PHE A 109
ALA A 194
LEU A 213
LEU A 209
 None
 1.01A 5x23A-1e4yA:
0.0		 5x23A-1e4yA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 PHE A 309
ASN A  57
LEU A 328
GLY A 355
ALA A 356
 None
 1.41A 5x23A-1h7wA:
0.0		 5x23A-1h7wA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhn CALNEXIN

(Canis lupus) 		PF00262
(Calreticulin) 		5 PHE A 190
LEU A 238
VAL A 448
LEU A 227
LEU A 201
 None
 1.27A 5x23A-1jhnA:
undetectable		 5x23A-1jhnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 ALA A 234
VAL A 130
GLY A 162
LEU A 210
LEU A 257
 None
None
None
None
EPE  A 455 (-4.9A)
 1.17A 5x23A-1jjiA:
undetectable		 5x23A-1jjiA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 PHE A 114
GLY A 293
ALA A 294
LEU A 359
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
DIF  A 501 (-4.4A)
HEM  A 500 (-4.0A)
 0.58A 5x23A-1nr6A:
55.6		 5x23A-1nr6A:
76.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		5 LEU A 251
VAL A 202
GLY A 248
LEU A 290
LEU A 264
 None
 1.20A 5x23A-1ogqA:
undetectable		 5x23A-1ogqA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 ALA C 816
PHE C 821
VAL C 803
GLY C 843
ALA C 879
 None
 1.02A 5x23A-1u6gC:
undetectable		 5x23A-1u6gC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 ALA A 215
LEU A 131
GLY A 134
ALA A 135
LEU A 190
 None
None
NAD  A1002 (-3.0A)
None
None
 0.99A 5x23A-1vrqA:
undetectable		 5x23A-1vrqA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 VAL A 167
LEU A 133
GLY A 181
LEU A 104
LEU A 126
 None
 1.38A 5x23A-1w5tA:
undetectable		 5x23A-1w5tA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		5 ALA B 434
VAL B 396
PHE B 335
GLY B 430
LEU B 398
 None
 1.17A 5x23A-1zunB:
undetectable		 5x23A-1zunB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A  40
VAL A 100
GLY A  43
ALA A  44
LEU A  51
 None
 1.38A 5x23A-2aifA:
undetectable		 5x23A-2aifA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		5 ALA A 261
VAL A  85
MET A  84
GLY A 294
ALA A 293
 None
 1.25A 5x23A-2cfbA:
undetectable		 5x23A-2cfbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Thermus
thermophilus) 		PF01451
(LMWPc) 		5 VAL A  40
LEU A 139
MET A  54
GLY A  23
LEU A 147
 None
 1.22A 5x23A-2cwdA:
undetectable		 5x23A-2cwdA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 361
MET A 362
GLY A 198
ALA A 261
LEU A 285
 None
 1.42A 5x23A-2dphA:
undetectable		 5x23A-2dphA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 5 VAL A  25
PHE A  45
GLY A  22
LEU A 120
LEU A 116
 None
 1.18A 5x23A-2dstA:
undetectable		 5x23A-2dstA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 ALA A 216
LEU A 132
GLY A 135
ALA A 136
LEU A 191
 None
None
NAD  A 999 (-3.0A)
None
None
 1.02A 5x23A-2gahA:
undetectable		 5x23A-2gahA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 PHE A 148
LEU A 155
GLY A 110
ALA A 111
LEU A 127
 None
None
FAD  A 601 (-3.5A)
FAD  A 601 (-4.1A)
None
 1.26A 5x23A-2gqtA:
undetectable		 5x23A-2gqtA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 VAL A 109
GLY A  45
ALA A  46
LEU A  55
LEU A  41
 SAH  A 301 (-3.8A)
SAH  A 301 (-3.7A)
None
None
None
 1.29A 5x23A-2gs9A:
undetectable		 5x23A-2gs9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		5 ALA A 100
ASN A 125
GLY A  90
ALA A  89
LEU A  47
 None
 1.29A 5x23A-2hi1A:
undetectable		 5x23A-2hi1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2

(Pseudomonas
aeruginosa) 		PF02127
(Peptidase_M18) 		5 ALA A 306
PHE A 352
LEU A 415
GLY A 420
ALA A 421
 None
 0.91A 5x23A-2ijzA:
undetectable		 5x23A-2ijzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 305
VAL A   3
MET A   1
LEU A 315
LEU A 193
 None
 1.32A 5x23A-2ip4A:
undetectable		 5x23A-2ip4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 ALA A  27
VAL A 254
ALA A 123
LEU A  72
LEU A 114
 None
 0.87A 5x23A-2jh3A:
undetectable		 5x23A-2jh3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		5 PHE A 223
GLY A 197
ALA A 198
LEU A 186
LEU A 208
 None
 1.47A 5x23A-2o6qA:
undetectable		 5x23A-2o6qA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A 395
VAL A 435
LEU A 399
ALA A 429
LEU A 232
 None
 1.07A 5x23A-2vqdA:
undetectable		 5x23A-2vqdA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 ALA A  89
VAL A 184
GLY A 187
ALA A 335
LEU A  13
 None
 1.20A 5x23A-2vz9A:
undetectable		 5x23A-2vz9A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		5 PHE A 254
LEU A 225
ALA A 213
LEU A 264
LEU A 256
 None
 1.27A 5x23A-2wzmA:
undetectable		 5x23A-2wzmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 157
VAL A 328
GLY A  13
ALA A  12
LEU A 120
 None
None
FAD  A1487 (-3.1A)
None
None
 1.18A 5x23A-2x50A:
undetectable		 5x23A-2x50A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 PHE A 548
LEU A 313
VAL A 491
GLY A 329
LEU A 556
 None
 1.28A 5x23A-2xgoA:
undetectable		 5x23A-2xgoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 ALA A 251
PHE A 301
VAL A 255
LEU A 315
LEU A 319
 None
 1.46A 5x23A-2zktA:
undetectable		 5x23A-2zktA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A  57
VAL A 188
ALA A 232
LEU A 165
LEU A 149
 None
 1.06A 5x23A-3ciaA:
undetectable		 5x23A-3ciaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		5 ALA A 120
LEU A  14
VAL A  31
LEU A  99
LEU A  96
 None
 0.97A 5x23A-3cm5A:
undetectable		 5x23A-3cm5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A3188
VAL A3037
GLY A3055
LEU A3075
LEU A3223
 None
 1.14A 5x23A-3cmvA:
undetectable		 5x23A-3cmvA:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		5 ALA A 105
ASN A 206
LEU A 210
VAL A 239
ALA A 299
 None
None
None
None
HEM  A 500 ( 3.3A)
 0.99A 5x23A-3e4eA:
50.6		 5x23A-3e4eA:
59.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7q TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 VAL A  46
PHE A   7
GLY A  49
LEU A  61
LEU A  19
 None
 0.98A 5x23A-3e7qA:
undetectable		 5x23A-3e7qA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		5 VAL A  78
VAL A 195
GLY A 210
ALA A  88
LEU A  76
 None
 1.18A 5x23A-3ff1A:
undetectable		 5x23A-3ff1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		5 ALA A1283
VAL A1107
MET A1106
GLY A1316
ALA A1315
 None
 1.25A 5x23A-3fq8A:
undetectable		 5x23A-3fq8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 ALA A 353
VAL A   6
GLY A  10
ALA A  47
LEU A  55
 None
None
FAD  A 444 (-3.1A)
None
None
 1.38A 5x23A-3g5sA:
undetectable		 5x23A-3g5sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		5 ALA A 329
VAL A 338
LEU A 352
LEU A  10
LEU A 345
 None
 1.36A 5x23A-3griA:
undetectable		 5x23A-3griA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 ALA A  31
VAL A  21
GLY A  17
ALA A  47
LEU A 312
 None
 1.08A 5x23A-3gwqA:
undetectable		 5x23A-3gwqA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  50
VAL A  45
ALA A  58
LEU A 135
LEU A  98
 None
 1.27A 5x23A-3h77A:
undetectable		 5x23A-3h77A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		5 VAL A  69
MET A 167
GLY A 116
ALA A 115
LEU A  61
 VAL  A  69 ( 0.6A)
MET  A 167 ( 0.0A)
GLY  A 116 ( 0.0A)
ALA  A 115 ( 0.0A)
LEU  A  61 ( 0.6A)
 1.06A 5x23A-3h7aA:
undetectable		 5x23A-3h7aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		5 ALA A  36
GLY A 229
ALA A 230
LEU A 146
LEU A 144
 None
 1.09A 5x23A-3k31A:
undetectable		 5x23A-3k31A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 ALA A 997
ASN A1057
GLY A1029
ALA A1025
LEU A1022
 None
 1.28A 5x23A-3kg7A:
undetectable		 5x23A-3kg7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13377
(Peripla_BP_3) 		5 ALA A  74
VAL A 249
VAL A 283
GLY A 257
ALA A 258
 None
 1.10A 5x23A-3kkeA:
undetectable		 5x23A-3kkeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3s ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		5 LEU A  23
VAL A 112
GLY A 120
ALA A 119
LEU A  97
 None
 1.17A 5x23A-3l3sA:
undetectable		 5x23A-3l3sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ASN A 196
LEU A 630
GLY A 145
ALA A 146
LEU A 642
 None
 1.47A 5x23A-3lk6A:
undetectable		 5x23A-3lk6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 VAL A 103
LEU A 117
GLY A 111
ALA A 107
LEU A 177
 None
 0.92A 5x23A-3moyA:
undetectable		 5x23A-3moyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 VAL A 299
GLY A 384
ALA A 507
LEU A 483
LEU A 499
 None
 1.24A 5x23A-3nvaA:
undetectable		 5x23A-3nvaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		5 ASN A  43
LEU A  69
GLY A  57
ALA A 138
LEU A  88
 None
 1.22A 5x23A-3nxlA:
undetectable		 5x23A-3nxlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyi FAT ACID-BINDING
PROTEIN

(Eubacterium
ventriosum) 		PF02645
(DegV) 		5 ALA A 274
VAL A 267
MET A 196
ALA A 129
LEU A  17
 None
None
STE  A 301 ( 4.6A)
None
None
 1.27A 5x23A-3nyiA:
undetectable		 5x23A-3nyiA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Ralstonia
pickettii) 		PF13378
(MR_MLE_C) 		5 ASN A  39
LEU A  65
GLY A  53
ALA A 134
LEU A  84
 None
 1.24A 5x23A-3p0wA:
undetectable		 5x23A-3p0wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 VAL A 339
ASN A 403
LEU A 397
LEU A 438
LEU A 343
 None
 1.09A 5x23A-3pdiA:
undetectable		 5x23A-3pdiA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnx PUTATIVE
SULFURTRANSFERASE
DSRE

(Syntrophomonas
wolfei) 		PF13686
(DrsE_2) 		5 VAL A 124
MET A 127
GLY A  43
LEU A  22
LEU A 107
 OCS  A 120 ( 3.8A)
None
None
None
None
 1.47A 5x23A-3pnxA:
undetectable		 5x23A-3pnxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 VAL A 101
GLY A 109
ALA A 105
LEU A 175
LEU A 119
 None
 1.02A 5x23A-3q0gA:
undetectable		 5x23A-3q0gA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		5 VAL A 253
MET A 207
GLY A 120
ALA A  59
LEU A  43
 None
 1.33A 5x23A-3qatA:
undetectable		 5x23A-3qatA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 638
VAL B 951
ALA B 922
LEU B1008
LEU B 936
 None
 1.06A 5x23A-3qd2B:
undetectable		 5x23A-3qd2B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF00155
(Aminotran_1_2) 		5 ALA A 252
VAL A 120
PHE A 124
GLY A 292
LEU A 335
 GOL  A 452 (-3.5A)
None
GOL  A 452 (-3.6A)
None
None
 0.94A 5x23A-3qguA:
undetectable		 5x23A-3qguA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A 366
VAL A 122
GLY A  99
ALA A  81
LEU A  46
 None
 1.45A 5x23A-3ramA:
undetectable		 5x23A-3ramA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		5 ALA A 111
GLY A  76
ALA A  75
LEU A 343
LEU A 337
 None
 1.20A 5x23A-3thcA:
undetectable		 5x23A-3thcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 VAL A1669
VAL A1640
ALA A1592
LEU A1582
LEU A1663
 None
 1.35A 5x23A-3va7A:
undetectable		 5x23A-3va7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
GLY A 372
ALA A 168
LEU A 346
LEU A 384
 VAL  A 382 ( 0.6A)
GLY  A 372 ( 0.0A)
ALA  A 168 ( 0.0A)
LEU  A 346 ( 0.6A)
LEU  A 384 ( 0.6A)
 1.37A 5x23A-3wd7A:
undetectable		 5x23A-3wd7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woz CLIP-ASSOCIATING
PROTEIN 2

(Mus musculus) 		no annotation 5 ALA A 796
PHE A 804
ALA A 813
LEU A 855
LEU A 851
 None
 0.99A 5x23A-3wozA:
undetectable		 5x23A-3wozA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 ALA H  56
PHE H  67
VAL H   5
LEU H  32
LEU H  71
 None
 1.46A 5x23A-3x1lH:
undetectable		 5x23A-3x1lH:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 LEU A 165
MET A 110
GLY A 144
ALA A 172
LEU A 251
 None
 1.08A 5x23A-3zheA:
undetectable		 5x23A-3zheA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		5 VAL A 898
LEU A 885
GLY A 890
LEU A 853
LEU A 869
 None
 1.16A 5x23A-3zqjA:
undetectable		 5x23A-3zqjA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		5 ALA A 279
MET A 325
GLY A 284
ALA A 292
LEU A 153
 None
 1.23A 5x23A-4c3yA:
undetectable		 5x23A-4c3yA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 VAL A  77
GLY A 204
ALA A 205
LEU A 224
LEU A 226
 None
 0.97A 5x23A-4faiA:
undetectable		 5x23A-4faiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ALA A 207
ASN A 169
GLY A 179
LEU A 119
LEU A 220
 None
 1.43A 5x23A-4fc7A:
undetectable		 5x23A-4fc7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ASN A 169
GLY A 179
ALA A 178
LEU A 119
LEU A 220
 None
 1.26A 5x23A-4fc7A:
undetectable		 5x23A-4fc7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		5 ASN A  41
LEU A  67
GLY A  55
ALA A 135
LEU A  86
 None
 1.23A 5x23A-4hn8A:
undetectable		 5x23A-4hn8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 VAL A 200
GLY A 165
ALA A 164
LEU A 360
LEU A 209
 None
None
EGR  A 501 (-3.7A)
None
None
 1.17A 5x23A-4j0kA:
undetectable		 5x23A-4j0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 VAL A  94
LEU A  76
GLY A  70
ALA A  69
LEU A  91
 None
 1.43A 5x23A-4k70A:
undetectable		 5x23A-4k70A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 ALA A 240
GLY A 232
ALA A 233
LEU A 207
LEU A 248
 None
 1.11A 5x23A-4kf7A:
undetectable		 5x23A-4kf7A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 ALA A  38
PHE A  83
GLY A  89
ALA A  88
LEU A 109
 None
 0.95A 5x23A-4nekA:
undetectable		 5x23A-4nekA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A 228
LEU A  88
GLY A 481
ALA A 482
LEU A 185
 None
 0.71A 5x23A-4qs9A:
undetectable		 5x23A-4qs9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		5 ARG A 258
GLY A 252
ALA A 253
LEU A 247
LEU A 265
 None
 1.38A 5x23A-4twbA:
undetectable		 5x23A-4twbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 VAL A 234
LEU A 242
GLY A 262
LEU A 272
LEU A 250
 None
 1.06A 5x23A-4u7lA:
undetectable		 5x23A-4u7lA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 248
GLY A  11
ALA A  12
LEU A  56
LEU A  37
 None
NAI  A 345 (-2.9A)
None
None
None
 1.47A 5x23A-4uupA:
undetectable		 5x23A-4uupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 VAL A  88
PHE A  52
LEU A  78
GLY A 129
ALA A 130
 None
 1.44A 5x23A-4xiaA:
undetectable		 5x23A-4xiaA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 234
VAL A 164
ALA A  91
LEU A  64
LEU A 303
 None
 1.38A 5x23A-4xvxA:
undetectable		 5x23A-4xvxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		5 VAL A 217
GLY A 149
ALA A 148
LEU A 141
LEU A 180
 None
 1.37A 5x23A-4y0xA:
undetectable		 5x23A-4y0xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 307
VAL A 355
GLY A 270
ALA A  91
LEU A 315
 None
 1.39A 5x23A-4zyjA:
undetectable		 5x23A-4zyjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 ALA A 672
LEU A 632
GLY A 687
ALA A 686
LEU A 612
 None
 1.36A 5x23A-5jwzA:
undetectable		 5x23A-5jwzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13481
(AAA_25)
PF13541
(ChlI) 		5 VAL A 294
VAL A 447
GLY A 391
ALA A 365
LEU A 361
 None
 1.16A 5x23A-5lkmA:
undetectable		 5x23A-5lkmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ALA A  72
GLY A 114
ALA A 113
LEU A 401
LEU A 405
 None
 1.17A 5x23A-5tp4A:
undetectable		 5x23A-5tp4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A  39
ASN A 185
LEU A 244
GLY A 187
ALA A 188
 None
 1.46A 5x23A-5u24A:
undetectable		 5x23A-5u24A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A 169
ASN A 272
GLY A 133
ALA A 159
LEU A 244
 None
 0.99A 5x23A-5u24A:
undetectable		 5x23A-5u24A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udf LIPOPROTEIN-RELEASIN
G SYSTEM
TRANSMEMBRANE
PROTEIN LOLE

(Acinetobacter
baumannii) 		PF12704
(MacB_PCD) 		5 LEU A 182
GLY A 126
ALA A 125
LEU A 174
LEU A 164
 None
 1.31A 5x23A-5udfA:
undetectable		 5x23A-5udfA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 5 ALA A  30
PHE A  22
ALA A  60
LEU A  84
LEU A  42
 None
 0.98A 5x23A-5wlyA:
undetectable		 5x23A-5wlyA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 VAL A1068
LEU A1021
ALA A1058
LEU A1113
LEU A1044
 None
 1.34A 5x23A-5x7sA:
undetectable		 5x23A-5x7sA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 12 ALA A 106
ARG A 108
VAL A 113
PHE A 114
ASN A 204
LEU A 208
VAL A 237
MET A 240
GLY A 296
ALA A 297
LEU A 362
LEU A 366
 LSN  A 501 ( 3.9A)
LSN  A 501 (-3.2A)
HEM  A 504 ( 3.7A)
LSN  A 503 (-3.8A)
LSN  A 501 (-3.7A)
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.3A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
 0.20A 5x23A-5xxiA:
63.7		 5x23A-5xxiA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		5 ASN A 255
GLY A 260
ALA A 263
LEU A 389
LEU A 393
 None
 1.35A 5x23A-5y1iA:
32.3		 5x23A-5y1iA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 5 ALA A 116
PHE A  90
GLY A  65
ALA A  66
LEU A  33
 None
 1.06A 5x23A-5z7rA:
undetectable		 5x23A-5z7rA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ASN C 878
GLY C 880
ALA C 881
LEU C 888
LEU C 892
 None
 0.98A 5x23A-6en4C:
undetectable		 5x23A-6en4C:
9.70