SIMILAR PATTERNS OF AMINO ACIDS FOR 5X23_A_LSNA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ALA C 236
VAL C 520
GLY C 416
LEU C 356
LEU C 294
 None
 0.88A 5x23A-1a5lC:
0.0		 5x23A-1a5lC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 VAL A  89
PHE A  53
LEU A  79
GLY A 130
ALA A 131
 None
 1.46A 5x23A-1bhwA:
0.0		 5x23A-1bhwA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		5 ALA A  81
VAL A  97
GLY A  74
LEU A 242
LEU A 247
 None
 1.32A 5x23A-1bwzA:
0.0		 5x23A-1bwzA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 VAL A 104
ASN A 126
GLY A  62
ALA A  61
LEU A 110
 None
 1.28A 5x23A-1bxnA:
0.0		 5x23A-1bxnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 PHE A  55
MET A 125
ALA A 149
LEU A 189
LEU A 187
 None
 1.21A 5x23A-1ciaA:
0.0		 5x23A-1ciaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dle COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  66
GLY A  44
ALA A  31
LEU A 112
LEU A 108
 None
 1.08A 5x23A-1dleA:
0.0		 5x23A-1dleA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4y ADENYLATE KINASE

(Escherichia
coli) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 VAL A 196
PHE A 109
ALA A 194
LEU A 213
LEU A 209
 None
 1.01A 5x23A-1e4yA:
0.0		 5x23A-1e4yA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 PHE A 309
ASN A  57
LEU A 328
GLY A 355
ALA A 356
 None
 1.41A 5x23A-1h7wA:
0.0		 5x23A-1h7wA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhn CALNEXIN

(Canis lupus) 		PF00262
(Calreticulin) 		5 PHE A 190
LEU A 238
VAL A 448
LEU A 227
LEU A 201
 None
 1.27A 5x23A-1jhnA:
undetectable		 5x23A-1jhnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 ALA A 234
VAL A 130
GLY A 162
LEU A 210
LEU A 257
 None
None
None
None
EPE  A 455 (-4.9A)
 1.17A 5x23A-1jjiA:
undetectable		 5x23A-1jjiA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 PHE A 114
GLY A 293
ALA A 294
LEU A 359
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
DIF  A 501 (-4.4A)
HEM  A 500 (-4.0A)
 0.58A 5x23A-1nr6A:
55.6		 5x23A-1nr6A:
76.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		5 LEU A 251
VAL A 202
GLY A 248
LEU A 290
LEU A 264
 None
 1.20A 5x23A-1ogqA:
undetectable		 5x23A-1ogqA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 ALA C 816
PHE C 821
VAL C 803
GLY C 843
ALA C 879
 None
 1.02A 5x23A-1u6gC:
undetectable		 5x23A-1u6gC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 ALA A 215
LEU A 131
GLY A 134
ALA A 135
LEU A 190
 None
None
NAD  A1002 (-3.0A)
None
None
 0.99A 5x23A-1vrqA:
undetectable		 5x23A-1vrqA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 VAL A 167
LEU A 133
GLY A 181
LEU A 104
LEU A 126
 None
 1.38A 5x23A-1w5tA:
undetectable		 5x23A-1w5tA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		5 ALA B 434
VAL B 396
PHE B 335
GLY B 430
LEU B 398
 None
 1.17A 5x23A-1zunB:
undetectable		 5x23A-1zunB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A  40
VAL A 100
GLY A  43
ALA A  44
LEU A  51
 None
 1.38A 5x23A-2aifA:
undetectable		 5x23A-2aifA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		5 ALA A 261
VAL A  85
MET A  84
GLY A 294
ALA A 293
 None
 1.25A 5x23A-2cfbA:
undetectable		 5x23A-2cfbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Thermus
thermophilus) 		PF01451
(LMWPc) 		5 VAL A  40
LEU A 139
MET A  54
GLY A  23
LEU A 147
 None
 1.22A 5x23A-2cwdA:
undetectable		 5x23A-2cwdA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 361
MET A 362
GLY A 198
ALA A 261
LEU A 285
 None
 1.42A 5x23A-2dphA:
undetectable		 5x23A-2dphA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 5 VAL A  25
PHE A  45
GLY A  22
LEU A 120
LEU A 116
 None
 1.18A 5x23A-2dstA:
undetectable		 5x23A-2dstA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 ALA A 216
LEU A 132
GLY A 135
ALA A 136
LEU A 191
 None
None
NAD  A 999 (-3.0A)
None
None
 1.02A 5x23A-2gahA:
undetectable		 5x23A-2gahA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 PHE A 148
LEU A 155
GLY A 110
ALA A 111
LEU A 127
 None
None
FAD  A 601 (-3.5A)
FAD  A 601 (-4.1A)
None
 1.26A 5x23A-2gqtA:
undetectable		 5x23A-2gqtA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 VAL A 109
GLY A  45
ALA A  46
LEU A  55
LEU A  41
 SAH  A 301 (-3.8A)
SAH  A 301 (-3.7A)
None
None
None
 1.29A 5x23A-2gs9A:
undetectable		 5x23A-2gs9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		5 ALA A 100
ASN A 125
GLY A  90
ALA A  89
LEU A  47
 None
 1.29A 5x23A-2hi1A:
undetectable		 5x23A-2hi1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2

(Pseudomonas
aeruginosa) 		PF02127
(Peptidase_M18) 		5 ALA A 306
PHE A 352
LEU A 415
GLY A 420
ALA A 421
 None
 0.91A 5x23A-2ijzA:
undetectable		 5x23A-2ijzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 305
VAL A   3
MET A   1
LEU A 315
LEU A 193
 None
 1.32A 5x23A-2ip4A:
undetectable		 5x23A-2ip4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 ALA A  27
VAL A 254
ALA A 123
LEU A  72
LEU A 114
 None
 0.87A 5x23A-2jh3A:
undetectable		 5x23A-2jh3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		5 PHE A 223
GLY A 197
ALA A 198
LEU A 186
LEU A 208
 None
 1.47A 5x23A-2o6qA:
undetectable		 5x23A-2o6qA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A 395
VAL A 435
LEU A 399
ALA A 429
LEU A 232
 None
 1.07A 5x23A-2vqdA:
undetectable		 5x23A-2vqdA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 ALA A  89
VAL A 184
GLY A 187
ALA A 335
LEU A  13
 None
 1.20A 5x23A-2vz9A:
undetectable		 5x23A-2vz9A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		5 PHE A 254
LEU A 225
ALA A 213
LEU A 264
LEU A 256
 None
 1.27A 5x23A-2wzmA:
undetectable		 5x23A-2wzmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 157
VAL A 328
GLY A  13
ALA A  12
LEU A 120
 None
None
FAD  A1487 (-3.1A)
None
None
 1.18A 5x23A-2x50A:
undetectable		 5x23A-2x50A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 PHE A 548
LEU A 313
VAL A 491
GLY A 329
LEU A 556
 None
 1.28A 5x23A-2xgoA:
undetectable		 5x23A-2xgoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 ALA A 251
PHE A 301
VAL A 255
LEU A 315
LEU A 319
 None
 1.46A 5x23A-2zktA:
undetectable		 5x23A-2zktA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A  57
VAL A 188
ALA A 232
LEU A 165
LEU A 149
 None
 1.06A 5x23A-3ciaA:
undetectable		 5x23A-3ciaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		5 ALA A 120
LEU A  14
VAL A  31
LEU A  99
LEU A  96
 None
 0.97A 5x23A-3cm5A:
undetectable		 5x23A-3cm5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A3188
VAL A3037
GLY A3055
LEU A3075
LEU A3223
 None
 1.14A 5x23A-3cmvA:
undetectable		 5x23A-3cmvA:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		5 ALA A 105
ASN A 206
LEU A 210
VAL A 239
ALA A 299
 None
None
None
None
HEM  A 500 ( 3.3A)
 0.99A 5x23A-3e4eA:
50.6		 5x23A-3e4eA:
59.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7q TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 VAL A  46
PHE A   7
GLY A  49
LEU A  61
LEU A  19
 None
 0.98A 5x23A-3e7qA:
undetectable		 5x23A-3e7qA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		5 VAL A  78
VAL A 195
GLY A 210
ALA A  88
LEU A  76
 None
 1.18A 5x23A-3ff1A:
undetectable		 5x23A-3ff1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		5 ALA A1283
VAL A1107
MET A1106
GLY A1316
ALA A1315
 None
 1.25A 5x23A-3fq8A:
undetectable		 5x23A-3fq8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 ALA A 353
VAL A   6
GLY A  10
ALA A  47
LEU A  55
 None
None
FAD  A 444 (-3.1A)
None
None
 1.38A 5x23A-3g5sA:
undetectable		 5x23A-3g5sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		5 ALA A 329
VAL A 338
LEU A 352
LEU A  10
LEU A 345
 None
 1.36A 5x23A-3griA:
undetectable		 5x23A-3griA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 ALA A  31
VAL A  21
GLY A  17
ALA A  47
LEU A 312
 None
 1.08A 5x23A-3gwqA:
undetectable		 5x23A-3gwqA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  50
VAL A  45
ALA A  58
LEU A 135
LEU A  98
 None
 1.27A 5x23A-3h77A:
undetectable		 5x23A-3h77A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		5 VAL A  69
MET A 167
GLY A 116
ALA A 115
LEU A  61
 VAL  A  69 ( 0.6A)
MET  A 167 ( 0.0A)
GLY  A 116 ( 0.0A)
ALA  A 115 ( 0.0A)
LEU  A  61 ( 0.6A)
 1.06A 5x23A-3h7aA:
undetectable		 5x23A-3h7aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		5 ALA A  36
GLY A 229
ALA A 230
LEU A 146
LEU A 144
 None
 1.09A 5x23A-3k31A:
undetectable		 5x23A-3k31A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 ALA A 997
ASN A1057
GLY A1029
ALA A1025
LEU A1022
 None
 1.28A 5x23A-3kg7A:
undetectable		 5x23A-3kg7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13377
(Peripla_BP_3) 		5 ALA A  74
VAL A 249
VAL A 283
GLY A 257
ALA A 258
 None
 1.10A 5x23A-3kkeA:
undetectable		 5x23A-3kkeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3s ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		5 LEU A  23
VAL A 112
GLY A 120
ALA A 119
LEU A  97
 None
 1.17A 5x23A-3l3sA:
undetectable		 5x23A-3l3sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ASN A 196
LEU A 630
GLY A 145
ALA A 146
LEU A 642
 None
 1.47A 5x23A-3lk6A:
undetectable		 5x23A-3lk6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 VAL A 103
LEU A 117
GLY A 111
ALA A 107
LEU A 177
 None
 0.92A 5x23A-3moyA:
undetectable		 5x23A-3moyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 VAL A 299
GLY A 384
ALA A 507
LEU A 483
LEU A 499
 None
 1.24A 5x23A-3nvaA:
undetectable		 5x23A-3nvaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		5 ASN A  43
LEU A  69
GLY A  57
ALA A 138
LEU A  88
 None
 1.22A 5x23A-3nxlA:
undetectable		 5x23A-3nxlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyi FAT ACID-BINDING
PROTEIN

(Eubacterium
ventriosum) 		PF02645
(DegV) 		5 ALA A 274
VAL A 267
MET A 196
ALA A 129
LEU A  17
 None
None
STE  A 301 ( 4.6A)
None
None
 1.27A 5x23A-3nyiA:
undetectable		 5x23A-3nyiA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Ralstonia
pickettii) 		PF13378
(MR_MLE_C) 		5 ASN A  39
LEU A  65
GLY A  53
ALA A 134
LEU A  84
 None
 1.24A 5x23A-3p0wA:
undetectable		 5x23A-3p0wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 VAL A 339
ASN A 403
LEU A 397
LEU A 438
LEU A 343
 None
 1.09A 5x23A-3pdiA:
undetectable		 5x23A-3pdiA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnx PUTATIVE
SULFURTRANSFERASE
DSRE

(Syntrophomonas
wolfei) 		PF13686
(DrsE_2) 		5 VAL A 124
MET A 127
GLY A  43
LEU A  22
LEU A 107
 OCS  A 120 ( 3.8A)
None
None
None
None
 1.47A 5x23A-3pnxA:
undetectable		 5x23A-3pnxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 VAL A 101
GLY A 109
ALA A 105
LEU A 175
LEU A 119
 None
 1.02A 5x23A-3q0gA:
undetectable		 5x23A-3q0gA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		5 VAL A 253
MET A 207
GLY A 120
ALA A  59
LEU A  43
 None
 1.33A 5x23A-3qatA:
undetectable		 5x23A-3qatA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 638
VAL B 951
ALA B 922
LEU B1008
LEU B 936
 None
 1.06A 5x23A-3qd2B:
undetectable		 5x23A-3qd2B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF00155
(Aminotran_1_2) 		5 ALA A 252
VAL A 120
PHE A 124
GLY A 292
LEU A 335
 GOL  A 452 (-3.5A)
None
GOL  A 452 (-3.6A)
None
None
 0.94A 5x23A-3qguA:
undetectable		 5x23A-3qguA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A 366
VAL A 122
GLY A  99
ALA A  81
LEU A  46
 None
 1.45A 5x23A-3ramA:
undetectable		 5x23A-3ramA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		5 ALA A 111
GLY A  76
ALA A  75
LEU A 343
LEU A 337
 None
 1.20A 5x23A-3thcA:
undetectable		 5x23A-3thcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 VAL A1669
VAL A1640
ALA A1592
LEU A1582
LEU A1663
 None
 1.35A 5x23A-3va7A:
undetectable		 5x23A-3va7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
GLY A 372
ALA A 168
LEU A 346
LEU A 384
 VAL  A 382 ( 0.6A)
GLY  A 372 ( 0.0A)
ALA  A 168 ( 0.0A)
LEU  A 346 ( 0.6A)
LEU  A 384 ( 0.6A)
 1.37A 5x23A-3wd7A:
undetectable		 5x23A-3wd7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woz CLIP-ASSOCIATING
PROTEIN 2

(Mus musculus) 		no annotation 5 ALA A 796
PHE A 804
ALA A 813
LEU A 855
LEU A 851
 None
 0.99A 5x23A-3wozA:
undetectable		 5x23A-3wozA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 ALA H  56
PHE H  67
VAL H   5
LEU H  32
LEU H  71
 None
 1.46A 5x23A-3x1lH:
undetectable		 5x23A-3x1lH:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 LEU A 165
MET A 110
GLY A 144
ALA A 172
LEU A 251
 None
 1.08A 5x23A-3zheA:
undetectable		 5x23A-3zheA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		5 VAL A 898
LEU A 885
GLY A 890
LEU A 853
LEU A 869
 None
 1.16A 5x23A-3zqjA:
undetectable		 5x23A-3zqjA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		5 ALA A 279
MET A 325
GLY A 284
ALA A 292
LEU A 153
 None
 1.23A 5x23A-4c3yA:
undetectable		 5x23A-4c3yA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 VAL A  77
GLY A 204
ALA A 205
LEU A 224
LEU A 226
 None
 0.97A 5x23A-4faiA:
undetectable		 5x23A-4faiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ALA A 207
ASN A 169
GLY A 179
LEU A 119
LEU A 220
 None
 1.43A 5x23A-4fc7A:
undetectable		 5x23A-4fc7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ASN A 169
GLY A 179
ALA A 178
LEU A 119
LEU A 220
 None
 1.26A 5x23A-4fc7A:
undetectable		 5x23A-4fc7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		5 ASN A  41
LEU A  67
GLY A  55
ALA A 135
LEU A  86
 None
 1.23A 5x23A-4hn8A:
undetectable		 5x23A-4hn8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 VAL A 200
GLY A 165
ALA A 164
LEU A 360
LEU A 209
 None
None
EGR  A 501 (-3.7A)
None
None
 1.17A 5x23A-4j0kA:
undetectable		 5x23A-4j0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 VAL A  94
LEU A  76
GLY A  70
ALA A  69
LEU A  91
 None
 1.43A 5x23A-4k70A:
undetectable		 5x23A-4k70A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 ALA A 240
GLY A 232
ALA A 233
LEU A 207
LEU A 248
 None
 1.11A 5x23A-4kf7A:
undetectable		 5x23A-4kf7A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 ALA A  38
PHE A  83
GLY A  89
ALA A  88
LEU A 109
 None
 0.95A 5x23A-4nekA:
undetectable		 5x23A-4nekA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A 228
LEU A  88
GLY A 481
ALA A 482
LEU A 185
 None
 0.71A 5x23A-4qs9A:
undetectable		 5x23A-4qs9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		5 ARG A 258
GLY A 252
ALA A 253
LEU A 247
LEU A 265
 None
 1.38A 5x23A-4twbA:
undetectable		 5x23A-4twbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 VAL A 234
LEU A 242
GLY A 262
LEU A 272
LEU A 250
 None
 1.06A 5x23A-4u7lA:
undetectable		 5x23A-4u7lA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 248
GLY A  11
ALA A  12
LEU A  56
LEU A  37
 None
NAI  A 345 (-2.9A)
None
None
None
 1.47A 5x23A-4uupA:
undetectable		 5x23A-4uupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 VAL A  88
PHE A  52
LEU A  78
GLY A 129
ALA A 130
 None
 1.44A 5x23A-4xiaA:
undetectable		 5x23A-4xiaA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 234
VAL A 164
ALA A  91
LEU A  64
LEU A 303
 None
 1.38A 5x23A-4xvxA:
undetectable		 5x23A-4xvxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		5 VAL A 217
GLY A 149
ALA A 148
LEU A 141
LEU A 180
 None
 1.37A 5x23A-4y0xA:
undetectable		 5x23A-4y0xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 307
VAL A 355
GLY A 270
ALA A  91
LEU A 315
 None
 1.39A 5x23A-4zyjA:
undetectable		 5x23A-4zyjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 ALA A 672
LEU A 632
GLY A 687
ALA A 686
LEU A 612
 None
 1.36A 5x23A-5jwzA:
undetectable		 5x23A-5jwzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13481
(AAA_25)
PF13541
(ChlI) 		5 VAL A 294
VAL A 447
GLY A 391
ALA A 365
LEU A 361
 None
 1.16A 5x23A-5lkmA:
undetectable		 5x23A-5lkmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ALA A  72
GLY A 114
ALA A 113
LEU A 401
LEU A 405
 None
 1.17A 5x23A-5tp4A:
undetectable		 5x23A-5tp4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A  39
ASN A 185
LEU A 244
GLY A 187
ALA A 188
 None
 1.46A 5x23A-5u24A:
undetectable		 5x23A-5u24A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A 169
ASN A 272
GLY A 133
ALA A 159
LEU A 244
 None
 0.99A 5x23A-5u24A:
undetectable		 5x23A-5u24A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udf LIPOPROTEIN-RELEASIN
G SYSTEM
TRANSMEMBRANE
PROTEIN LOLE

(Acinetobacter
baumannii) 		PF12704
(MacB_PCD) 		5 LEU A 182
GLY A 126
ALA A 125
LEU A 174
LEU A 164
 None
 1.31A 5x23A-5udfA:
undetectable		 5x23A-5udfA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 5 ALA A  30
PHE A  22
ALA A  60
LEU A  84
LEU A  42
 None
 0.98A 5x23A-5wlyA:
undetectable		 5x23A-5wlyA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 VAL A1068
LEU A1021
ALA A1058
LEU A1113
LEU A1044
 None
 1.34A 5x23A-5x7sA:
undetectable		 5x23A-5x7sA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 12 ALA A 106
ARG A 108
VAL A 113
PHE A 114
ASN A 204
LEU A 208
VAL A 237
MET A 240
GLY A 296
ALA A 297
LEU A 362
LEU A 366
 LSN  A 501 ( 3.9A)
LSN  A 501 (-3.2A)
HEM  A 504 ( 3.7A)
LSN  A 503 (-3.8A)
LSN  A 501 (-3.7A)
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.3A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
 0.20A 5x23A-5xxiA:
63.7		 5x23A-5xxiA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		5 ASN A 255
GLY A 260
ALA A 263
LEU A 389
LEU A 393
 None
 1.35A 5x23A-5y1iA:
32.3		 5x23A-5y1iA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 5 ALA A 116
PHE A  90
GLY A  65
ALA A  66
LEU A  33
 None
 1.06A 5x23A-5z7rA:
undetectable		 5x23A-5z7rA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ASN C 878
GLY C 880
ALA C 881
LEU C 888
LEU C 892
 None
 0.98A 5x23A-6en4C:
undetectable		 5x23A-6en4C:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 LEU A 155
VAL A 421
ASP A 422
 None
 0.58A 5x23A-1c3cA:
0.0		 5x23A-1c3cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 LEU A 324
VAL A 536
ASP A 537
 None
 0.59A 5x23A-1gpeA:
0.0		 5x23A-1gpeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 3 LEU O  25
VAL O 322
ASP O 323
 None
 0.66A 5x23A-1jn0O:
0.0		 5x23A-1jn0O:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 LEU A 160
VAL A 342
ASP A 343
 None
 0.66A 5x23A-1kkrA:
undetectable		 5x23A-1kkrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 LEU A 169
VAL A 151
ASP A 152
 None
 0.65A 5x23A-1llpA:
0.0		 5x23A-1llpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 LEU A 307
VAL A 389
ASP A 388
 None
 0.59A 5x23A-1np7A:
0.0		 5x23A-1np7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 LEU A 405
VAL A 126
ASP A 127
 None
 0.66A 5x23A-1odoA:
29.5		 5x23A-1odoA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 426
VAL A 339
ASP A 340
 None
 0.00A 5x23A-1q5aA:
undetectable		 5x23A-1q5aA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LEU A 364
VAL A 579
ASP A 578
 None
 0.53A 5x23A-1qf7A:
0.0		 5x23A-1qf7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		3 LEU E   6
VAL E  30
ASP E  32
 None
HH0  E 327 ( 4.7A)
HH0  E 327 (-2.7A)
 0.65A 5x23A-1qrpE:
undetectable		 5x23A-1qrpE:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 LEU A 712
VAL A  45
ASP A  46
 None
 0.66A 5x23A-1t6pA:
undetectable		 5x23A-1t6pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq8 HYPOTHETICAL PROTEIN
RV1636

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		3 LEU A  47
VAL A  34
ASP A  35
 None
 0.59A 5x23A-1tq8A:
undetectable		 5x23A-1tq8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuz DIACYLGLYCEROL
KINASE ALPHA

(Homo sapiens) 		PF14513
(DAG_kinase_N) 		3 LEU A  31
VAL A  99
ASP A  98
 None
 0.65A 5x23A-1tuzA:
undetectable		 5x23A-1tuzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u83 PHOSPHOSULFOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF02679
(ComA) 		3 LEU A 153
VAL A 191
ASP A 192
 None
 0.55A 5x23A-1u83A:
undetectable		 5x23A-1u83A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		3 LEU A 184
VAL A 134
ASP A 135
 None
 0.56A 5x23A-1wkyA:
undetectable		 5x23A-1wkyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wm9 GTP CYCLOHYDROLASE I

(Thermus
thermophilus) 		PF01227
(GTP_cyclohydroI) 		3 LEU A 152
VAL A 139
ASP A 140
 None
 0.64A 5x23A-1wm9A:
undetectable		 5x23A-1wm9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi3 THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF02581
(TMP-TENI) 		3 LEU A 146
VAL A 157
ASP A 177
 None
 0.64A 5x23A-1xi3A:
undetectable		 5x23A-1xi3A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 LEU A 735
VAL A 762
ASP A 763
 None
 0.52A 5x23A-1ygpA:
undetectable		 5x23A-1ygpA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvw PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Bacillus cereus) 		PF01503
(PRA-PH) 		3 LEU A   8
VAL A  64
ASP A  65
 None
 0.59A 5x23A-1yvwA:
undetectable		 5x23A-1yvwA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap9 ACETYLGLUTAMATE
KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		3 LEU A 100
VAL A 189
ASP A 185
 None
 0.62A 5x23A-2ap9A:
undetectable		 5x23A-2ap9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn4 RAS-RELATED PROTEIN
R-RAS

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A 105
VAL A 179
ASP A 180
 None
 0.58A 5x23A-2fn4A:
undetectable		 5x23A-2fn4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		3 LEU A  97
VAL A 149
ASP A 150
 None
 0.63A 5x23A-2g7lA:
undetectable		 5x23A-2g7lA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		3 LEU A 188
VAL A 147
ASP A 148
 None
 0.57A 5x23A-2guuA:
undetectable		 5x23A-2guuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6h HYPOTHETICAL PROTEIN
ATU0120

(Agrobacterium
fabrum) 		PF06041
(DUF924) 		3 LEU A 109
VAL A  13
ASP A  14
 None
 0.60A 5x23A-2i6hA:
undetectable		 5x23A-2i6hA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A 306
VAL A 270
ASP A 271
 None
 0.61A 5x23A-2i6tA:
undetectable		 5x23A-2i6tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 LEU A 231
VAL A 247
ASP A 267
 None
 0.66A 5x23A-2jbmA:
undetectable		 5x23A-2jbmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		3 LEU A 455
VAL A 412
ASP A 413
 SF4  A 650 (-4.1A)
None
None
 0.49A 5x23A-2jh3A:
undetectable		 5x23A-2jh3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox5 SOXY PROTEIN

(Paracoccus
denitrificans) 		no annotation 3 LEU Y  88
VAL Y   3
ASP Y   4
 None
 0.64A 5x23A-2ox5Y:
undetectable		 5x23A-2ox5Y:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056

(Geobacillus
kaustophilus) 		PF08282
(Hydrolase_3) 		3 LEU A  82
VAL A 177
ASP A 176
 None
 0.62A 5x23A-2pq0A:
undetectable		 5x23A-2pq0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		3 LEU A 461
VAL A 423
ASP A 422
 None
 0.50A 5x23A-2qzpA:
undetectable		 5x23A-2qzpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		PF00500
(Late_protein_L1) 		3 LEU A 195
VAL A 201
ASP A 202
 None
 0.60A 5x23A-2r5jA:
undetectable		 5x23A-2r5jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 LEU B 271
VAL B 377
ASP B 378
 None
 0.43A 5x23A-2rhqB:
undetectable		 5x23A-2rhqB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		3 LEU A 483
VAL A 192
ASP A 193
 None
 0.59A 5x23A-2wsxA:
undetectable		 5x23A-2wsxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 LEU A 342
VAL A 384
ASP A 379
 GOL  A1733 (-4.6A)
CL  A1798 ( 3.9A)
PGR  A1760 ( 4.3A)
 0.64A 5x23A-2xe4A:
undetectable		 5x23A-2xe4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 LEU A 530
VAL A 725
ASP A 726
 None
 0.61A 5x23A-2xt6A:
undetectable		 5x23A-2xt6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A

(Mycobacterium
tuberculosis) 		PF00977
(His_biosynth) 		3 LEU A  74
VAL A  35
ASP A  36
 None
 0.65A 5x23A-2y89A:
undetectable		 5x23A-2y89A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		3 LEU A   4
VAL A  19
ASP A  20
 None
 0.48A 5x23A-2ykfA:
undetectable		 5x23A-2ykfA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 LEU A 272
VAL A 229
ASP A 230
 None
 0.61A 5x23A-3afgA:
undetectable		 5x23A-3afgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		3 LEU A 260
VAL A 218
ASP A 219
 None
 0.55A 5x23A-3at7A:
undetectable		 5x23A-3at7A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 LEU A  29
VAL A 327
ASP A 328
 None
 0.65A 5x23A-3b20A:
undetectable		 5x23A-3b20A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		3 LEU A 274
VAL A  50
ASP A  54
 None
 0.56A 5x23A-3by9A:
undetectable		 5x23A-3by9A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOC

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04896
(AmoC) 		3 LEU C 101
VAL B  23
ASP B  27
 None
 0.62A 5x23A-3chxC:
undetectable		 5x23A-3chxC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		3 LEU A 101
VAL A 189
ASP A 188
 None
None
FBP  A3499 (-2.8A)
 0.58A 5x23A-3d1rA:
undetectable		 5x23A-3d1rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 LEU A 245
VAL A 227
ASP A 228
 None
 0.56A 5x23A-3dbgA:
33.3		 5x23A-3dbgA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 LEU A 730
VAL A 687
ASP A 689
 None
 0.62A 5x23A-3f2bA:
undetectable		 5x23A-3f2bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		3 LEU A 296
VAL A 250
ASP A 253
 None
 0.62A 5x23A-3fpzA:
undetectable		 5x23A-3fpzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LEU A 696
VAL A 672
ASP A 673
 None
 0.56A 5x23A-3hkzA:
undetectable		 5x23A-3hkzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Schistosoma
mansoni) 		PF01652
(IF4E) 		3 LEU A 149
VAL A 110
ASP A 111
 None
 0.65A 5x23A-3hxgA:
undetectable		 5x23A-3hxgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		3 LEU A 123
VAL A  84
ASP A  85
 None
 0.65A 5x23A-3iuuA:
undetectable		 5x23A-3iuuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00682
(HMGL-like) 		3 LEU A 377
VAL A 395
ASP A 396
 None
 0.56A 5x23A-3ivuA:
undetectable		 5x23A-3ivuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		3 LEU A   6
VAL A  91
ASP A  94
 None
 0.64A 5x23A-3qm1A:
undetectable		 5x23A-3qm1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 LEU A 347
VAL A  39
ASP A  38
 None
 0.62A 5x23A-3ttsA:
undetectable		 5x23A-3ttsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		3 LEU A 214
VAL A 258
ASP A 259
 None
 0.62A 5x23A-3uzuA:
undetectable		 5x23A-3uzuA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		3 LEU A 356
VAL A 342
ASP A 343
 None
None
TRS  A 509 ( 3.0A)
 0.45A 5x23A-3vocA:
undetectable		 5x23A-3vocA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Streptomyces
chartreusis) 		PF01370
(Epimerase) 		3 LEU A  27
VAL A 217
ASP A 218
 None
 0.64A 5x23A-3vpsA:
undetectable		 5x23A-3vpsA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 LEU A 530
VAL A 725
ASP A 726
 None
 0.60A 5x23A-3zhrA:
undetectable		 5x23A-3zhrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 LEU A 490
VAL A 455
ASP A 456
 None
 0.55A 5x23A-4aioA:
undetectable		 5x23A-4aioA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 LEU A 690
VAL A 660
ASP A 661
 None
 0.66A 5x23A-4aioA:
undetectable		 5x23A-4aioA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LEU A 101
VAL A  42
ASP A  43
 None
 0.59A 5x23A-4b3iA:
undetectable		 5x23A-4b3iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		3 LEU A 205
VAL A 235
ASP A 234
 None
 0.63A 5x23A-4czeA:
undetectable		 5x23A-4czeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Bacillus
anthracis) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		3 LEU A 133
VAL A 167
ASP A 168
 LEU  A 133 ( 0.6A)
VAL  A 167 ( 0.6A)
ASP  A 168 ( 0.6A)
 0.64A 5x23A-4dlkA:
undetectable		 5x23A-4dlkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 LEU A  80
VAL A 119
ASP A 118
 None
 0.53A 5x23A-4fysA:
undetectable		 5x23A-4fysA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		3 LEU A  92
VAL A 121
ASP A 122
 None
 0.65A 5x23A-4g0bA:
undetectable		 5x23A-4g0bA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Rattus
norvegicus) 		PF01239
(PPTA) 		3 LEU A 363
VAL A 316
ASP A 317
 None
 0.53A 5x23A-4gtrA:
undetectable		 5x23A-4gtrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF15414
(DUF4621) 		3 LEU A 332
VAL A  54
ASP A  53
 MLY  A 333 ( 3.7A)
None
None
 0.66A 5x23A-4h3wA:
undetectable		 5x23A-4h3wA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		3 LEU A 323
VAL A 382
ASP A 383
 None
 0.65A 5x23A-4hpvA:
undetectable		 5x23A-4hpvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		3 LEU A  70
VAL A 241
ASP A 242
 None
 0.53A 5x23A-4i62A:
undetectable		 5x23A-4i62A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sus scrofa) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 LEU A 229
VAL A 245
ASP A 265
 None
 0.62A 5x23A-4i9aA:
undetectable		 5x23A-4i9aA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in0 THIOREDOXIN-LIKE
PROTEIN 4B

(Homo sapiens) 		PF02966
(DIM1) 		3 LEU A  26
VAL A  14
ASP A  15
 None
 0.58A 5x23A-4in0A:
undetectable		 5x23A-4in0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		3 LEU A  58
VAL A 316
ASP A 317
 BME  A 404 (-4.6A)
None
None
 0.62A 5x23A-4ixuA:
undetectable		 5x23A-4ixuA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k12 CHOLINE BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF05062
(RICH) 		3 LEU B  38
VAL B  73
ASP B  74
 None
 0.49A 5x23A-4k12B:
undetectable		 5x23A-4k12B:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LEU A 182
VAL A 171
ASP A 172
 None
 0.45A 5x23A-4l1kA:
undetectable		 5x23A-4l1kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 LEU A 555
VAL A 518
ASP A 519
 None
 0.56A 5x23A-4l68A:
undetectable		 5x23A-4l68A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		3 LEU A 204
VAL A 401
ASP A 402
 None
 0.65A 5x23A-4n7rA:
undetectable		 5x23A-4n7rA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		3 LEU A 797
VAL A 738
ASP A 739
 None
None
MN  A1206 (-4.6A)
 0.59A 5x23A-4ogcA:
undetectable		 5x23A-4ogcA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		3 LEU A 446
VAL A 381
ASP A 382
 None
 0.65A 5x23A-4po0A:
undetectable		 5x23A-4po0A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		3 LEU A 194
VAL A  61
ASP A  62
 4CS  A 405 (-4.9A)
None
None
 0.56A 5x23A-4q0mA:
undetectable		 5x23A-4q0mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		3 LEU A 207
VAL A 176
ASP A 177
 None
 0.58A 5x23A-4q62A:
undetectable		 5x23A-4q62A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		3 LEU A 228
VAL A  34
ASP A  35
 None
 0.58A 5x23A-4ql6A:
undetectable		 5x23A-4ql6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		3 LEU B 197
VAL B 166
ASP B 167
 None
 0.56A 5x23A-4qtuB:
undetectable		 5x23A-4qtuB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		3 LEU A 174
VAL A 122
ASP A 121
 None
 0.66A 5x23A-4r42A:
undetectable		 5x23A-4r42A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		3 LEU A  59
VAL A  68
ASP A  71
 None
 0.55A 5x23A-4ryaA:
undetectable		 5x23A-4ryaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF00628
(PHD)
PF12148
(TTD) 		3 LEU A 242
VAL A 302
ASP A 303
 None
UNX  A 409 ( 4.5A)
UNX  A 409 ( 3.6A)
 0.58A 5x23A-4tvrA:
undetectable		 5x23A-4tvrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 3 LEU D  43
VAL D  16
ASP D  17
 None
 0.51A 5x23A-4x28D:
undetectable		 5x23A-4x28D:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 LEU A 558
VAL A 381
ASP A 382
 None
 0.63A 5x23A-4y9lA:
undetectable		 5x23A-4y9lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 LEU A 306
VAL A 521
ASP A 522
 None
 0.55A 5x23A-4ynuA:
undetectable		 5x23A-4ynuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		3 LEU A 172
VAL A  65
ASP A  66
 None
 0.47A 5x23A-4z11A:
undetectable		 5x23A-4z11A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A 304
VAL A 270
ASP A 271
 None
 0.65A 5x23A-4z17A:
undetectable		 5x23A-4z17A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 3 LEU A 128
VAL A 112
ASP A 113
 None
 0.51A 5x23A-5a7tA:
undetectable		 5x23A-5a7tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 3 LEU A 128
VAL A 112
ASP A 113
 None
 0.55A 5x23A-5a7yA:
undetectable		 5x23A-5a7yA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		3 LEU A 463
VAL A 430
ASP A 431
 None
 0.59A 5x23A-5bp8A:
undetectable		 5x23A-5bp8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Mus musculus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 LEU O 108
VAL O 429
ASP O 430
 None
 0.59A 5x23A-5c7iO:
undetectable		 5x23A-5c7iO:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Homo sapiens) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 LEU O  76
VAL O 397
ASP O 398
 None
 0.55A 5x23A-5c7oO:
undetectable		 5x23A-5c7oO:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		3 LEU A 259
VAL A 179
ASP A 180
 None
 0.52A 5x23A-5ddsA:
undetectable		 5x23A-5ddsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 LEU A 433
VAL A1457
ASP A1458
 None
 0.59A 5x23A-5dotA:
undetectable		 5x23A-5dotA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		3 LEU A 234
VAL A 216
ASP A 217
 None
 0.30A 5x23A-5e78A:
35.1		 5x23A-5e78A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 LEU A 183
VAL A 242
ASP A 243
 None
 0.52A 5x23A-5eytA:
undetectable		 5x23A-5eytA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		3 LEU A 317
VAL A 295
ASP A 296
 None
 0.65A 5x23A-5fmqA:
undetectable		 5x23A-5fmqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		3 LEU A 312
VAL A 385
ASP A 386
 None
 0.61A 5x23A-5ft6A:
undetectable		 5x23A-5ft6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 LEU a 413
VAL a 181
ASP a 182
 None
 0.66A 5x23A-5gw5a:
undetectable		 5x23A-5gw5a:
21.05