SIMILAR PATTERNS OF AMINO ACIDS FOR 5X1F_P_CHDP304
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1914 | SIGNAL RECOGNITIONPARTICLE 9/14 FUSIONPROTEIN (Mus musculus) |
PF02290(SRP14)PF05486(SRP9-21) | 4 | LEU A2086PHE A2017LEU A2013PHE A2009 | None | 0.81A | 5x1fP-1914A:undetectable5x1fW-1914A:0.0 | 5x1fP-1914A:19.405x1fW-1914A:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1buc | BUTYRYL-COADEHYDROGENASE (Megasphaeraelsdenii) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | ARG A 31LEU A 41PHE A 19LEU A 24 | None | 0.97A | 5x1fP-1bucA:4.45x1fW-1bucA:0.0 | 5x1fP-1bucA:17.695x1fW-1bucA:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dj3 | ADENYLOSUCCINATESYNTHETASE (Triticumaestivum) |
PF00709(Adenylsucc_synt) | 4 | LEU A 164PHE A 175LEU A 179PHE A 183 | None | 0.64A | 5x1fP-1dj3A:undetectable5x1fW-1dj3A:0.0 | 5x1fP-1dj3A:19.005x1fW-1dj3A:9.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e2t | N-HYDROXYARYLAMINEO-ACETYLTRANSFERASE (Salmonellaenterica) |
PF00797(Acetyltransf_2) | 4 | ARG A 88LEU A 90PHE A 174LEU A 176 | None | 1.01A | 5x1fP-1e2tA:undetectable5x1fW-1e2tA:0.0 | 5x1fP-1e2tA:23.155x1fW-1e2tA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fqt | RIESKE-TYPEFERREDOXIN OFBIPHENYL DIOXYGENASE (Paraburkholderiaxenovorans) |
PF00355(Rieske) | 4 | LYS A 87LEU A 86PHE A 70LEU A 50 | None | 0.95A | 5x1fP-1fqtA:undetectable5x1fW-1fqtA:undetectable | 5x1fP-1fqtA:15.485x1fW-1fqtA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fym | HEAT SHOCKTRANSCRIPTIONPROTEIN (Kluyveromyceslactis) |
PF00447(HSF_DNA-bind) | 4 | LEU A 201PHE A 197LEU A 252PHE A 278 | None | 1.02A | 5x1fP-1fymA:undetectable5x1fW-1fymA:undetectable | 5x1fP-1fymA:13.905x1fW-1fymA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jkw | CYCLIN H (Homo sapiens) |
PF00134(Cyclin_N)PF16899(Cyclin_C_2) | 4 | ARG A 102LEU A 106PHE A 110LEU A 129 | None | 0.85A | 5x1fP-1jkwA:0.75x1fW-1jkwA:0.0 | 5x1fP-1jkwA:20.525x1fW-1jkwA:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kl7 | THREONINE SYNTHASE (Saccharomycescerevisiae) |
PF00291(PALP)PF14821(Thr_synth_N) | 4 | LEU A 83PHE A 130LEU A 134PHE A 138 | None | 0.73A | 5x1fP-1kl7A:undetectable5x1fW-1kl7A:0.0 | 5x1fP-1kl7A:21.245x1fW-1kl7A:8.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mdf | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | LEU A 31PHE A 27PHE A 93LEU A 56 | None | 1.03A | 5x1fP-1mdfA:undetectable5x1fW-1mdfA:0.0 | 5x1fP-1mdfA:17.855x1fW-1mdfA:8.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ny5 | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00072(Response_reg)PF00158(Sigma54_activat) | 4 | LEU A 194PHE A 204LEU A 208PHE A 227 | None | 0.90A | 5x1fP-1ny5A:undetectable5x1fW-1ny5A:undetectable | 5x1fP-1ny5A:19.755x1fW-1ny5A:9.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oj4 | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE (Escherichiacoli) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 4 | LYS A 271LEU A 35PHE A 34PHE A 245 | None | 0.93A | 5x1fP-1oj4A:undetectable5x1fW-1oj4A:undetectable | 5x1fP-1oj4A:23.795x1fW-1oj4A:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p32 | MITOCHONDRIAL MATRIXPROTEIN, SF2P32 (Homo sapiens) |
PF02330(MAM33) | 4 | LEU A 86PHE A 82LEU A 275PHE A 271 | None | 1.02A | 5x1fP-1p32A:undetectable5x1fW-1p32A:undetectable | 5x1fP-1p32A:20.225x1fW-1p32A:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sk7 | HYPOTHETICAL PROTEINPA-HO (Pseudomonasaeruginosa) |
PF01126(Heme_oxygenase) | 4 | LYS A 34PHE A 197LEU A 193PHE A 189 | NoneNoneNoneHEM A 300 (-3.7A) | 0.89A | 5x1fP-1sk7A:1.85x1fW-1sk7A:undetectable | 5x1fP-1sk7A:21.295x1fW-1sk7A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhf | PERIPLASMIC DIVALENTCATION TOLERANCEPROTEIN (Thermotogamaritima) |
PF03091(CutA1) | 4 | LEU A 21PHE A 30PHE A 55LEU A 69 | None | 1.03A | 5x1fP-1vhfA:undetectable5x1fW-1vhfA:undetectable | 5x1fP-1vhfA:15.715x1fW-1vhfA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vku | ACYL CARRIER PROTEIN (Thermotogamaritima) |
PF00550(PP-binding) | 4 | LEU A 70PHE A 48LEU A 44PHE A 36 | None | 0.80A | 5x1fP-1vkuA:undetectable5x1fW-1vkuA:undetectable | 5x1fP-1vkuA:13.645x1fW-1vkuA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vyn | ARGONAUTE2 (Drosophilamelanogaster) |
PF02170(PAZ) | 5 | ARG A 30LEU A 11PHE A 14LEU A 33PHE A 32 | None | 1.48A | 5x1fP-1vynA:undetectable5x1fW-1vynA:undetectable | 5x1fP-1vynA:22.735x1fW-1vynA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8s | FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS I (Thermoproteustenax) |
PF01791(DeoC) | 4 | LYS A 215LEU A 214PHE A 243LEU A 247 | None | 1.02A | 5x1fP-1w8sA:undetectable5x1fW-1w8sA:undetectable | 5x1fP-1w8sA:22.115x1fW-1w8sA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wrj | METHYLATED-DNA--PROTEIN-CYSTEINEMETHYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF01035(DNA_binding_1) | 4 | LEU A 60PHE A 45LEU A 49PHE A 53 | None | 0.95A | 5x1fP-1wrjA:undetectable5x1fW-1wrjA:undetectable | 5x1fP-1wrjA:16.605x1fW-1wrjA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2haj | DNA PRIMASE (Escherichiacoli) |
PF08278(DnaG_DnaB_bind) | 4 | LEU A 454PHE A 535LEU A 539PHE A 543 | None | 0.78A | 5x1fP-2hajA:undetectable5x1fW-2hajA:undetectable | 5x1fP-2hajA:19.015x1fW-2hajA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibd | POSSIBLETRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF00440(TetR_N) | 4 | LEU A 131PHE A 135PHE A 74LEU A 70 | None | 0.92A | 5x1fP-2ibdA:2.25x1fW-2ibdA:undetectable | 5x1fP-2ibdA:24.735x1fW-2ibdA:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ngr | PROTEIN (GTPASEACTIVATING PROTEIN(RHG)) (Homo sapiens) |
PF00620(RhoGAP) | 4 | LEU B 391PHE B 454LEU B 446PHE B 442 | None | 1.04A | 5x1fP-2ngrB:undetectable5x1fW-2ngrB:undetectable | 5x1fP-2ngrB:21.655x1fW-2ngrB:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nmp | CYSTATHIONINEGAMMA-LYASE (Homo sapiens) |
PF01053(Cys_Met_Meta_PP) | 4 | LEU A 78PHE A 15PHE A 18LEU A 262 | None | 1.04A | 5x1fP-2nmpA:undetectable5x1fW-2nmpA:undetectable | 5x1fP-2nmpA:20.255x1fW-2nmpA:10.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nt8 | COBALAMINADENOSYLTRANSFERASE (Lactobacillusreuteri) |
PF01923(Cob_adeno_trans) | 4 | LEU A 95PHE A 154LEU A 158PHE A 162 | None | 0.81A | 5x1fP-2nt8A:2.75x1fW-2nt8A:undetectable | 5x1fP-2nt8A:21.305x1fW-2nt8A:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2opt | ACTII PROTEIN (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 4 | ARG A 75LEU A 79PHE A 83LEU A 49 | None | 0.66A | 5x1fP-2optA:3.15x1fW-2optA:undetectable | 5x1fP-2optA:23.195x1fW-2optA:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otn | DIAMINOPIMELATEEPIMERASE (Bacillusanthracis) |
PF01678(DAP_epimerase) | 4 | ARG A 81LYS A 271LEU A 258LEU A 12 | None | 0.72A | 5x1fP-2otnA:undetectable5x1fW-2otnA:undetectable | 5x1fP-2otnA:21.785x1fW-2otnA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1n | SKP1-LIKE PROTEIN 1ATRANSPORT INHIBITORRESPONSE 1 PROTEIN (Arabidopsisthaliana;Arabidopsisthaliana) |
PF01466(Skp1)PF03931(Skp1_POZ)PF12937(F-box-like) | 4 | PHE A 99PHE B 9LEU B 14PHE B 18 | None | 0.93A | 5x1fP-2p1nA:undetectable5x1fW-2p1nA:undetectable | 5x1fP-2p1nA:18.585x1fW-2p1nA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qhp | FRUCTOKINASE (Bacteroidesthetaiotaomicron) |
PF00294(PfkB) | 4 | LYS A 175LEU A 174PHE A 168LEU A 202 | NoneNoneEDO A 298 ( 4.9A)EDO A 298 (-4.9A) | 0.98A | 5x1fP-2qhpA:undetectable5x1fW-2qhpA:undetectable | 5x1fP-2qhpA:21.575x1fW-2qhpA:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2riu | 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATESYNTHASE (Candidaalbicans) |
PF00926(DHBP_synthase) | 4 | LEU A 113PHE A 93PHE A 123LEU A 70 | None | 0.97A | 5x1fP-2riuA:undetectable5x1fW-2riuA:undetectable | 5x1fP-2riuA:21.665x1fW-2riuA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 4 | ARG A 532LEU A 536PHE A 543LEU A 501 | None | 1.02A | 5x1fP-2xgoA:undetectable5x1fW-2xgoA:undetectable | 5x1fP-2xgoA:16.905x1fW-2xgoA:7.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Prochlorococcusmarinus) |
PF00148(Oxidored_nitro) | 4 | LEU C 35PHE C 60PHE C 33LEU C 87 | None | 0.99A | 5x1fP-2ynmC:undetectable5x1fW-2ynmC:undetectable | 5x1fP-2ynmC:21.925x1fW-2ynmC:9.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeu | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Rhodobactercapsulatus) |
PF00148(Oxidored_nitro) | 4 | LEU A 44PHE A 69PHE A 42LEU A 96 | None | 0.97A | 5x1fP-3aeuA:undetectable5x1fW-3aeuA:undetectable | 5x1fP-3aeuA:22.025x1fW-3aeuA:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ba3 | PYRIDOXAMINE5'-PHOSPHATEOXIDASE-LIKE PROTEIN (Lactobacillusplantarum) |
no annotation | 4 | LEU A 123PHE A 121PHE A 45LEU A 18 | None | 0.94A | 5x1fP-3ba3A:undetectable5x1fW-3ba3A:undetectable | 5x1fP-3ba3A:21.195x1fW-3ba3A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9b | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 75 (Saccharomycescerevisiae) |
PF00956(NAP) | 4 | LYS A 59LEU A 62PHE A 68PHE A 107 | None | 1.05A | 5x1fP-3c9bA:undetectable5x1fW-3c9bA:undetectable | 5x1fP-3c9bA:17.545x1fW-3c9bA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3deg | GTP-BINDING PROTEINLEPA (Escherichiacoli) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF06421(LepA_C) | 4 | LEU C 73PHE C 75PHE C 7LEU C 176 | None | 1.04A | 5x1fP-3degC:undetectable5x1fW-3degC:undetectable | 5x1fP-3degC:17.435x1fW-3degC:7.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4e | CYTOCHROME P450 2E1 (Homo sapiens) |
PF00067(p450) | 4 | LYS A 461LEU A 460PHE A 458LEU A 312 | None | 1.03A | 5x1fP-3e4eA:undetectable5x1fW-3e4eA:undetectable | 5x1fP-3e4eA:19.835x1fW-3e4eA:7.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3evz | METHYLTRANSFERASE (Pyrococcusfuriosus) |
PF05175(MTS) | 4 | LEU A 202PHE A 153LEU A 186PHE A 182 | None | 0.96A | 5x1fP-3evzA:undetectable5x1fW-3evzA:undetectable | 5x1fP-3evzA:19.785x1fW-3evzA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1z | PUTATIVE LYSYL-TRNASYNTHETASE (Salmonellaenterica) |
PF00152(tRNA-synt_2) | 4 | ARG A 188LEU A 192PHE A 196PHE A 153 | None | 0.91A | 5x1fP-3g1zA:undetectable5x1fW-3g1zA:undetectable | 5x1fP-3g1zA:20.945x1fW-3g1zA:9.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gaj | COBALAMINADENOSYLTRANSFERASEPDUO-LIKE PROTEIN (Lactobacillusreuteri) |
PF01923(Cob_adeno_trans) | 4 | LEU A 95PHE A 154LEU A 158PHE A 162 | None | 0.81A | 5x1fP-3gajA:2.75x1fW-3gajA:undetectable | 5x1fP-3gajA:21.165x1fW-3gajA:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrt | METALLOREGULATORSCAR (Streptococcusgordonii) |
PF01325(Fe_dep_repress)PF02742(Fe_dep_repr_C)PF04023(FeoA) | 4 | ARG A 74LYS A 75LEU A 78PHE A 82 | None | 0.68A | 5x1fP-3hrtA:undetectable5x1fW-3hrtA:undetectable | 5x1fP-3hrtA:18.615x1fW-3hrtA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iay | DNA POLYMERASE DELTACATALYTIC SUBUNIT (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | LEU A 227PHE A 187LEU A 183PHE A 179 | None | 0.98A | 5x1fP-3iayA:3.25x1fW-3iayA:undetectable | 5x1fP-3iayA:13.745x1fW-3iayA:5.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iv0 | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | LEU A 230PHE A 151LEU A 155PHE A 159 | None | 0.85A | 5x1fP-3iv0A:1.95x1fW-3iv0A:undetectable | 5x1fP-3iv0A:20.575x1fW-3iv0A:8.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 4 | LEU A 530PHE A 569LEU A 566PHE A 526 | None | 0.96A | 5x1fP-3j9dA:undetectable5x1fW-3j9dA:undetectable | 5x1fP-3j9dA:13.315x1fW-3j9dA:5.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6x | SOLUTE-BINDINGPROTEIN MA_0280 (Methanosarcinaacetivorans) |
PF13531(SBP_bac_11) | 4 | LEU A 58PHE A 311LEU A 315PHE A 118 | None | 0.87A | 5x1fP-3k6xA:undetectable5x1fW-3k6xA:undetectable | 5x1fP-3k6xA:20.875x1fW-3k6xA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lcr | TAUTOMYCETINBIOSYNTHETIC PKS (Streptomycessp. CK4412) |
PF00975(Thioesterase) | 4 | LEU A 229PHE A 174LEU A 178PHE A 182 | None | 0.90A | 5x1fP-3lcrA:undetectable5x1fW-3lcrA:undetectable | 5x1fP-3lcrA:20.455x1fW-3lcrA:9.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvu | TENA FAMILYTRANSCRIPTIONALREGULATOR (Ruegeria sp.TM1040) |
PF03070(TENA_THI-4) | 4 | LEU A 204PHE A 208LEU A 187PHE A 195 | NoneNoneNoneEDO A 231 (-3.8A) | 0.84A | 5x1fP-3mvuA:undetectable5x1fW-3mvuA:undetectable | 5x1fP-3mvuA:20.305x1fW-3mvuA:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q8i | ODORANT BINDINGPROTEIN (Anophelesgambiae) |
PF01395(PBP_GOBP) | 4 | LEU A 44PHE A 21LEU A 31PHE A 36 | None | 1.03A | 5x1fP-3q8iA:undetectable5x1fW-3q8iA:undetectable | 5x1fP-3q8iA:17.725x1fW-3q8iA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd5 | MYPAA.01249.C (Mycobacteriumavium) |
PF00106(adh_short) | 4 | ARG A 131LEU A 191PHE A 246LEU A 241 | None | 0.96A | 5x1fP-3rd5A:undetectable5x1fW-3rd5A:undetectable | 5x1fP-3rd5A:21.795x1fW-3rd5A:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4y | PROTEIN MXIG (Shigellaflexneri) |
PF09480(PrgH) | 4 | LYS A 106LEU A 105PHE A 103PHE A 79 | None | 0.70A | 5x1fP-4a4yA:undetectable5x1fW-4a4yA:undetectable | 5x1fP-4a4yA:19.175x1fW-4a4yA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4abn | TETRATRICOPEPTIDEREPEAT PROTEIN 5 (Mus musculus) |
PF16669(TTC5_OB) | 4 | LYS A 281PHE A 355LEU A 274PHE A 405 | None | 0.99A | 5x1fP-4abnA:undetectable5x1fW-4abnA:undetectable | 5x1fP-4abnA:19.535x1fW-4abnA:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c8q | DNA TOPOISOMERASE2-ASSOCIATED PROTEINPAT1 (Saccharomycescerevisiae) |
PF09770(PAT1) | 4 | LEU H 562PHE H 587LEU H 527PHE H 523 | None | 0.74A | 5x1fP-4c8qH:undetectable5x1fW-4c8qH:undetectable | 5x1fP-4c8qH:19.405x1fW-4c8qH:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cn8 | PROXIMAL THREADMATRIX PROTEIN 1 (Mytilusgalloprovincialis) |
PF00092(VWA) | 4 | LYS A 234LEU A 233PHE A 79LEU A 83 | None | 0.89A | 5x1fP-4cn8A:undetectable5x1fW-4cn8A:undetectable | 5x1fP-4cn8A:20.005x1fW-4cn8A:7.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e5t | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME, C-TERMINALDOMAIN PROTEIN (Labrenziaalexandrii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 321PHE A 23PHE A 25LEU A 376 | None | 0.97A | 5x1fP-4e5tA:undetectable5x1fW-4e5tA:undetectable | 5x1fP-4e5tA:21.585x1fW-4e5tA:9.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flx | DNA POLYMERASE 1 (Pyrococcusabyssi) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | ARG A 266LEU A 352PHE A 356LEU A 333 | ARG A 266 ( 0.6A)LEU A 352 ( 0.6A)PHE A 356 ( 1.3A)LEU A 333 ( 0.6A) | 0.91A | 5x1fP-4flxA:undetectable5x1fW-4flxA:undetectable | 5x1fP-4flxA:13.495x1fW-4flxA:6.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hqf | THROMBOSPONDIN-RELATED ANONYMOUSPROTEIN, TRAP (Plasmodiumfalciparum) |
PF00092(VWA) | 5 | ARG A 176LYS A 173LEU A 172PHE A 198LEU A 202 | None | 1.07A | 5x1fP-4hqfA:undetectable5x1fW-4hqfA:undetectable | 5x1fP-4hqfA:20.745x1fW-4hqfA:10.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1s | MELANOMADIFFERENTIATIONASSOCIATED PROTEIN-5 (Sus scrofa) |
PF00271(Helicase_C) | 4 | LYS A 681LEU A 684PHE A 549LEU A 553 | None | 0.70A | 5x1fP-4i1sA:undetectable5x1fW-4i1sA:undetectable | 5x1fP-4i1sA:19.635x1fW-4i1sA:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4it4 | CG17282 (Drosophilamelanogaster) |
no annotation | 4 | LEU A 83PHE A 110LEU A 112PHE A 90 | None | 1.05A | 5x1fP-4it4A:4.75x1fW-4it4A:undetectable | 5x1fP-4it4A:20.445x1fW-4it4A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0m | SERINE/THREONINE-PROTEIN KINASEBRI1-LIKE 1 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 4 | LEU A 228PHE A 230LEU A 203PHE A 199 | None | 0.97A | 5x1fP-4j0mA:undetectable5x1fW-4j0mA:undetectable | 5x1fP-4j0mA:16.015x1fW-4j0mA:5.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgv | NUCLEAR RECEPTORSUBFAMILY 4 GROUP AMEMBER 1 (Homo sapiens) |
PF00104(Hormone_recep) | 4 | LEU A 570PHE A 592LEU A 596PHE A 598 | None | 1.00A | 5x1fP-4jgvA:undetectable5x1fW-4jgvA:undetectable | 5x1fP-4jgvA:21.995x1fW-4jgvA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kd5 | ABC-TYPE TRANSPORTSYSTEM,MOLYBDENUM-SPECIFICEXTRACELLULARSOLUTE-BINDINGPROTEIN (Clostridioidesdifficile) |
no annotation | 4 | LEU C 121PHE C 261LEU C 252PHE C 248 | None | 0.99A | 5x1fP-4kd5C:undetectable5x1fW-4kd5C:undetectable | 5x1fP-4kd5C:19.085x1fW-4kd5C:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4u | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00072(Response_reg)PF00158(Sigma54_activat) | 4 | LEU A 194PHE A 204LEU A 208PHE A 227 | None | 0.83A | 5x1fP-4l4uA:undetectable5x1fW-4l4uA:undetectable | 5x1fP-4l4uA:18.325x1fW-4l4uA:10.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lnq | INTERFERON-ACTIVABLEPROTEIN 202 (Mus musculus) |
PF02760(HIN) | 4 | LEU A 218PHE A 239LEU A 216PHE A 188 | None | 1.02A | 5x1fP-4lnqA:undetectable5x1fW-4lnqA:undetectable | 5x1fP-4lnqA:19.625x1fW-4lnqA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6q | VOSA (Aspergillusnidulans) |
PF11754(Velvet) | 4 | LYS A 132LEU A 131PHE A 129LEU A 121 | None | 0.82A | 5x1fP-4n6qA:undetectable5x1fW-4n6qA:undetectable | 5x1fP-4n6qA:22.185x1fW-4n6qA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q62 | LEUCINE-RICHREPEAT-AND COILEDCOIL-CONTAININGPROTEIN (Legionellapneumophila) |
PF13855(LRR_8) | 5 | LYS A 159LEU A 161PHE A 179PHE A 164LEU A 136 | None | 1.47A | 5x1fP-4q62A:undetectable5x1fW-4q62A:undetectable | 5x1fP-4q62A:18.185x1fW-4q62A:9.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0m | MCYG PROTEIN (Microcystisaeruginosa) |
no annotation | 4 | LEU B 75PHE B 83LEU B 87PHE B 91 | None | 0.70A | 5x1fP-4r0mB:undetectable5x1fW-4r0mB:undetectable | 5x1fP-4r0mB:17.425x1fW-4r0mB:7.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgp | CSM6_III-A (Streptococcusmutans) |
PF09659(Cas_Csm6) | 4 | LEU A 221PHE A 220PHE A 98LEU A 86 | None | 0.94A | 5x1fP-4rgpA:2.45x1fW-4rgpA:undetectable | 5x1fP-4rgpA:20.825x1fW-4rgpA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnc | ESTERASE (Rhodococcus sp.ECU1013) |
PF12697(Abhydrolase_6) | 4 | ARG A 196LEU A 163PHE A 185LEU A 189 | None | 0.80A | 5x1fP-4rncA:undetectable5x1fW-4rncA:undetectable | 5x1fP-4rncA:21.325x1fW-4rncA:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxm | POSSIBLE SUGAR ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Mannheimiahaemolytica) |
PF13407(Peripla_BP_4) | 4 | LEU A 31PHE A 29LEU A 42PHE A 38 | NoneNoneNoneINS A 401 (-4.5A) | 0.97A | 5x1fP-4rxmA:undetectable5x1fW-4rxmA:undetectable | 5x1fP-4rxmA:20.815x1fW-4rxmA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud4 | POLY(A) RNAPOLYMERASE PROTEINCID1 (Schizosaccharomycespombe) |
PF01909(NTP_transf_2)PF03828(PAP_assoc) | 4 | LYS A 144LEU A 145LEU A 125PHE A 121 | None | 0.75A | 5x1fP-4ud4A:undetectable5x1fW-4ud4A:undetectable | 5x1fP-4ud4A:19.955x1fW-4ud4A:10.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5j | ADENYLATE KINASE (Streptococcuspneumoniae) |
PF00406(ADK) | 4 | LYS A 69LEU A 72PHE A 82LEU A 84 | None | 1.03A | 5x1fP-4w5jA:undetectable5x1fW-4w5jA:undetectable | 5x1fP-4w5jA:20.165x1fW-4w5jA:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wn9 | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Clostridiumpasteurianum) |
PF00148(Oxidored_nitro) | 4 | LYS A 331LEU A 334LEU A 503PHE A 499 | NoneNone XE A 604 ( 4.2A) XE A 604 (-3.8A) | 0.59A | 5x1fP-4wn9A:undetectable5x1fW-4wn9A:undetectable | 5x1fP-4wn9A:17.155x1fW-4wn9A:8.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7v | PUTATIVE GLYCOSIDASEPH117-RELATED (Bacteroidesthetaiotaomicron) |
PF04041(Glyco_hydro_130) | 4 | LYS B 253LEU B 254PHE B 317PHE B 309 | None | 0.84A | 5x1fP-5a7vB:undetectable5x1fW-5a7vB:undetectable | 5x1fP-5a7vB:20.785x1fW-5a7vB:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aox | SIGNAL RECOGNITIONPARTICLE 14 KDAPROTEIN (Homo sapiens) |
PF02290(SRP14) | 4 | LEU B 86PHE B 17LEU B 13PHE B 9 | None | 0.79A | 5x1fP-5aoxB:undetectable5x1fW-5aoxB:undetectable | 5x1fP-5aoxB:17.865x1fW-5aoxB:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ckm | MANNAN-BINDINGLECTIN SERINEPEPTIDASE 2 (Rattusnorvegicus) |
PF00431(CUB)PF07645(EGF_CA) | 4 | ARG A 80LEU A 70PHE A 111PHE A 42 | None | 0.98A | 5x1fP-5ckmA:undetectable5x1fW-5ckmA:undetectable | 5x1fP-5ckmA:22.335x1fW-5ckmA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cww | NUCLEOPORIN NUP82NUCLEOPORIN NUP159 (Chaetomiumthermophilum;Chaetomiumthermophilum) |
no annotationno annotation | 4 | ARG C1447LYS C1448LEU C1451LEU B 425 | None | 0.96A | 5x1fP-5cwwC:undetectable5x1fW-5cwwC:undetectable | 5x1fP-5cwwC:8.895x1fW-5cwwC:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7w | SERRALYSIN (Serratiamarcescens) |
PF00353(HemolysinCabind)PF00413(Peptidase_M10)PF08548(Peptidase_M10_C) | 4 | LYS A 57LEU A 58PHE A 60LEU A 182 | LYS A 57 ( 0.0A)LEU A 58 ( 0.6A)PHE A 60 ( 1.3A)LEU A 182 ( 0.6A) | 0.90A | 5x1fP-5d7wA:undetectable5x1fW-5d7wA:undetectable | 5x1fP-5d7wA:19.925x1fW-5d7wA:8.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ddb | MENIN (Homo sapiens) |
PF05053(Menin) | 4 | LEU A 551PHE A 553LEU A 414PHE A 410 | None | 0.98A | 5x1fP-5ddbA:1.95x1fW-5ddbA:undetectable | 5x1fP-5ddbA:17.435x1fW-5ddbA:9.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyt | ADENYLOSUCCINATELYASE (Schistosomamansoni) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | LEU A 47PHE A 49PHE A 207LEU A 217 | None | 1.00A | 5x1fP-5eytA:3.95x1fW-5eytA:undetectable | 5x1fP-5eytA:18.885x1fW-5eytA:9.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g3y | ADENYLATE KINSE (syntheticconstruct) |
PF00406(ADK)PF05191(ADK_lid) | 4 | LYS A 69LEU A 72PHE A 81LEU A 83 | None | 0.85A | 5x1fP-5g3yA:undetectable5x1fW-5g3yA:undetectable | 5x1fP-5g3yA:19.195x1fW-5g3yA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgr | ORANGE CAROTENOIDPROTEIN (OCP) (Nostoc sp. PCC7120) |
PF02136(NTF2)PF09150(Carot_N) | 4 | LYS A 69LEU A 68PHE A 109LEU A 113 | NoneNoneNone45D A 501 ( 4.8A) | 1.00A | 5x1fP-5hgrA:undetectable5x1fW-5hgrA:undetectable | 5x1fP-5hgrA:20.255x1fW-5hgrA:12.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipx | ORF49 PROTEIN (Humangammaherpesvirus8) |
PF04793(Herpes_BBRF1) | 4 | LEU A 87PHE A 204LEU A 208PHE A 212 | None | 0.81A | 5x1fP-5ipxA:8.25x1fW-5ipxA:undetectable | 5x1fP-5ipxA:20.475x1fW-5ipxA:11.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5iy5 | CYTOCHROME C OXIDASESUBUNIT 3 (Bos taurus) |
PF00510(COX3) | 6 | ARG C 156LYS C 157LEU C 160PHE C 164PHE C 219LEU C 223 | CHD C 307 (-4.0A)NoneCHD C 307 ( 3.9A)CHD C 307 (-3.9A)NoneNone | 0.21A | 5x1fP-5iy5C:36.65x1fW-5iy5C:undetectable | 5x1fP-5iy5C:100.005x1fW-5iy5C:10.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbg | LGP2 (Gallus gallus) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 4 | LEU A 385PHE A 434LEU A 432PHE A 360 | None | 0.94A | 5x1fP-5jbgA:2.05x1fW-5jbgA:undetectable | 5x1fP-5jbgA:15.815x1fW-5jbgA:6.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbw | 3-HYDROXYBUTYRYL-COADEHYDRATASE (Myxococcusxanthus) |
PF00378(ECH_1) | 4 | LEU A 31PHE A 80LEU A 84PHE A 88 | None | 0.73A | 5x1fP-5jbwA:undetectable5x1fW-5jbwA:undetectable | 5x1fP-5jbwA:20.915x1fW-5jbwA:13.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jlt | MIDDLE TRANSCRIPTIONREGULATORY PROTEINMOTA (Escherichiavirus T4) |
PF09158(MotCF) | 4 | LYS A 130LEU A 128LEU A 121PHE A 152 | None | 1.03A | 5x1fP-5jltA:undetectable5x1fW-5jltA:undetectable | 5x1fP-5jltA:16.675x1fW-5jltA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ju6 | BETA-GLUCOSIDASE (Rasamsoniaemersonii) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ARG A 82LEU A 83PHE A 50LEU A 54 | None | 0.85A | 5x1fP-5ju6A:undetectable5x1fW-5ju6A:undetectable | 5x1fP-5ju6A:13.895x1fW-5ju6A:5.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5llq | METHYLATED-DNA--PROTEIN-CYSTEINEMETHYLTRANSFERASE (Sulfolobussolfataricus) |
PF01035(DNA_binding_1) | 4 | LEU A 60PHE A 45LEU A 49PHE A 53 | None | 0.88A | 5x1fP-5llqA:undetectable5x1fW-5llqA:undetectable | 5x1fP-5llqA:19.925x1fW-5llqA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsk | PROTEIN MIS12HOMOLOGPOLYAMINE-MODULATEDFACTOR 1 (Homo sapiens;Homo sapiens) |
PF05859(Mis12)PF03980(Nnf1) | 4 | LEU A 78PHE A 79PHE B 45LEU B 49 | None | 0.82A | 5x1fP-5lskA:3.35x1fW-5lskA:2.7 | 5x1fP-5lskA:21.825x1fW-5lskA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nbs | BETA-GLUCOSIDASE (Neurosporacrassa) |
no annotation | 4 | ARG A 78LEU A 79PHE A 46LEU A 50 | None | 0.94A | 5x1fP-5nbsA:undetectable5x1fW-5nbsA:undetectable | 5x1fP-5nbsA:undetectable5x1fW-5nbsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oen | INTERFERONREGULATORY FACTOR 9 (Mus musculus) |
no annotation | 4 | PHE A 339PHE A 322LEU A 326PHE A 330 | None | 0.83A | 5x1fP-5oenA:undetectable5x1fW-5oenA:undetectable | 5x1fP-5oenA:undetectable5x1fW-5oenA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u47 | PENICILLIN BINDINGPROTEIN 2X (Streptococcusthermophilus) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF03793(PASTA) | 4 | LYS A 167LEU A 170LEU A 130PHE A 155 | None | 0.82A | 5x1fP-5u47A:undetectable5x1fW-5u47A:undetectable | 5x1fP-5u47A:13.825x1fW-5u47A:6.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umq | GLYOXALASE/BLEOMYCINRESISANCEPROTEIN/DIOXYGENASE (Streptomycessp. CB03234) |
no annotation | 4 | LEU A 121PHE A 119PHE A 111LEU A 88 | None | 0.87A | 5x1fP-5umqA:undetectable5x1fW-5umqA:undetectable | 5x1fP-5umqA:undetectable5x1fW-5umqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xge | UNCHARACTERIZEDPROTEIN PA0861 (Pseudomonasaeruginosa) |
no annotation | 4 | LYS A 699PHE A 665LEU A 661PHE A 657 | None | 0.79A | 5x1fP-5xgeA:undetectable5x1fW-5xgeA:undetectable | 5x1fP-5xgeA:undetectable5x1fW-5xgeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjj | MULTI DRUG EFFLUXTRANSPORTER (Camelina sativa) |
PF01554(MatE) | 4 | LEU A 348PHE A 344PHE A 380LEU A 376 | None | 0.78A | 5x1fP-5xjjA:3.35x1fW-5xjjA:undetectable | 5x1fP-5xjjA:22.225x1fW-5xjjA:8.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6r | GENOME POLYPROTEIN (Pestivirus C) |
no annotation | 4 | LYS A 592PHE A 547LEU A 551PHE A 323 | None | 1.02A | 5x1fP-5y6rA:undetectable5x1fW-5y6rA:undetectable | 5x1fP-5y6rA:undetectable5x1fW-5y6rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6al7 | 12-EPI-HAPALINDOLEC/U SYNTHASE (Fischerella sp.ATCC 43239) |
no annotation | 4 | LYS A 144PHE A 88LEU A 147PHE A 210 | None | 0.99A | 5x1fP-6al7A:undetectable5x1fW-6al7A:undetectable | 5x1fP-6al7A:undetectable5x1fW-6al7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bo7 | HYPOXANTHINEPHOSPHORIBOSYLTRANSFERASE (Plasmodiumvivax) |
no annotation | 4 | LEU A 50PHE A 191LEU A 173PHE A 82 | None | 0.96A | 5x1fP-6bo7A:undetectable5x1fW-6bo7A:undetectable | 5x1fP-6bo7A:undetectable5x1fW-6bo7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bpc | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 4 | LYS A 437LEU A 440PHE A 388LEU A 392 | None | 0.63A | 5x1fP-6bpcA:6.85x1fW-6bpcA:undetectable | 5x1fP-6bpcA:undetectable5x1fW-6bpcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c26 | DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT 1DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT OST5 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
no annotationno annotation | 4 | LEU 5 73PHE 5 28PHE 5 77PHE 1 447 | None | 0.93A | 5x1fP-6c265:3.35x1fW-6c265:undetectable | 5x1fP-6c265:undetectable5x1fW-6c265:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d04 | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 4 | LYS E 437LEU E 440PHE E 388LEU E 392 | None | 0.78A | 5x1fP-6d04E:5.25x1fW-6d04E:undetectable | 5x1fP-6d04E:undetectable5x1fW-6d04E:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dex | SUPPRESSOR OFHYDROXYUREASENSITIVITY PROTEIN2 (Eremotheciumgossypii) |
no annotation | 4 | ARG B 36LEU B 38PHE B 39PHE B 158 | None | 0.95A | 5x1fP-6dexB:undetectable5x1fW-6dexB:undetectable | 5x1fP-6dexB:undetectable5x1fW-6dexB:undetectable |