SIMILAR PATTERNS OF AMINO ACIDS FOR 5X1F_C_CHDC304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a75 PARVALBUMIN

(Merlangius
merlangus) 		PF13499
(EF-hand_7) 		4 ARG A  75
LEU A  67
PHE A  70
LEU A  77
 None
 1.16A 5x1fC-1a75A:
undetectable
5x1fJ-1a75A:
0.0		 5x1fC-1a75A:
14.84
5x1fJ-1a75A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 LEU A 205
PHE A 165
LEU A 199
PHE A 195
 None
 1.03A 5x1fC-1bixA:
1.2
5x1fJ-1bixA:
0.0		 5x1fC-1bixA:
18.33
5x1fJ-1bixA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex6 GUANYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00625
(Guanylate_kin) 		4 LEU A 178
PHE A 181
LEU A  18
PHE A  22
 None
 1.17A 5x1fC-1ex6A:
undetectable
5x1fJ-1ex6A:
0.0		 5x1fC-1ex6A:
20.45
5x1fJ-1ex6A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.84A 5x1fC-1jkwA:
0.6
5x1fJ-1jkwA:
0.0		 5x1fC-1jkwA:
20.52
5x1fJ-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 569
PHE A 566
LEU A 135
PHE A 140
 None
 1.15A 5x1fC-1ogyA:
undetectable
5x1fJ-1ogyA:
0.0		 5x1fC-1ogyA:
15.37
5x1fJ-1ogyA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 ARG A  39
LEU A 389
PHE A 391
LEU A 332
 None
 1.17A 5x1fC-1qfxA:
undetectable
5x1fJ-1qfxA:
0.0		 5x1fC-1qfxA:
18.36
5x1fJ-1qfxA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes;
Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 ARG B 136
LEU A 135
LEU A 653
PHE A 131
 None
 1.05A 5x1fC-1qlbB:
1.1
5x1fJ-1qlbB:
0.0		 5x1fC-1qlbB:
21.43
5x1fJ-1qlbB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnr TUMOR NECROSIS
FACTOR BETA

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A  33
PHE A 165
LEU A  65
PHE A  58
 None
 0.89A 5x1fC-1tnrA:
undetectable
5x1fJ-1tnrA:
0.0		 5x1fC-1tnrA:
20.16
5x1fJ-1tnrA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.82A 5x1fC-1u8vA:
3.8
5x1fJ-1u8vA:
undetectable		 5x1fC-1u8vA:
19.70
5x1fJ-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vph HYPOTHETICAL PROTEIN
SSO2532

(Sulfolobus
solfataricus) 		PF01894
(UPF0047) 		4 LEU A  95
PHE A  94
LEU A 121
PHE A  16
 None
 1.19A 5x1fC-1vphA:
undetectable
5x1fJ-1vphA:
undetectable		 5x1fC-1vphA:
18.39
5x1fJ-1vphA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 LEU B 110
PHE B 114
LEU B 100
PHE B 196
 None
 1.21A 5x1fC-1xt0B:
undetectable
5x1fJ-1xt0B:
undetectable		 5x1fC-1xt0B:
20.18
5x1fJ-1xt0B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 LEU A  75
PHE A  77
LEU A  92
PHE A  88
 None
 1.19A 5x1fC-1yirA:
undetectable
5x1fJ-1yirA:
undetectable		 5x1fC-1yirA:
21.09
5x1fJ-1yirA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 184
PHE A 158
LEU A 176
PHE A 172
 None
 0.83A 5x1fC-1yw6A:
undetectable
5x1fJ-1yw6A:
undetectable		 5x1fC-1yw6A:
20.54
5x1fJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.09A 5x1fC-2becA:
undetectable
5x1fJ-2becA:
undetectable		 5x1fC-2becA:
25.67
5x1fJ-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		4 LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.09A 5x1fC-2ghbA:
undetectable
5x1fJ-2ghbA:
undetectable		 5x1fC-2ghbA:
19.69
5x1fJ-2ghbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 LEU A  60
PHE A  37
LEU A  73
PHE A  74
 None
 1.19A 5x1fC-2jjyA:
undetectable
5x1fJ-2jjyA:
undetectable		 5x1fC-2jjyA:
21.14
5x1fJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqn CRK-LIKE PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		4 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.14A 5x1fC-2lqnA:
undetectable
5x1fJ-2lqnA:
undetectable		 5x1fC-2lqnA:
19.49
5x1fJ-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		4 LEU A  85
PHE A  86
LEU A  94
PHE A  99
 None
 1.16A 5x1fC-2nr4A:
2.4
5x1fJ-2nr4A:
undetectable		 5x1fC-2nr4A:
22.61
5x1fJ-2nr4A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 295
PHE A 291
LEU A  76
PHE A  72
 None
 1.08A 5x1fC-2ongA:
2.1
5x1fJ-2ongA:
undetectable		 5x1fC-2ongA:
19.05
5x1fJ-2ongA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.61A 5x1fC-2optA:
3.2
5x1fJ-2optA:
undetectable		 5x1fC-2optA:
23.19
5x1fJ-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB

(Escherichia
coli) 		PF01725
(Ham1p_like) 		4 ARG A 126
LEU A  -6
PHE A  24
LEU A 134
 None
 1.08A 5x1fC-2pyuA:
undetectable
5x1fJ-2pyuA:
undetectable		 5x1fC-2pyuA:
21.93
5x1fJ-2pyuA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		4 ARG A  83
LEU A  24
PHE A  26
LEU A  15
 None
 1.13A 5x1fC-2q2rA:
undetectable
5x1fJ-2q2rA:
undetectable		 5x1fC-2q2rA:
21.78
5x1fJ-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		4 LEU A 208
PHE A 223
LEU A 174
PHE A 168
 None
None
None
EDO  A 298 ( 4.9A)
 1.15A 5x1fC-2qhpA:
undetectable
5x1fJ-2qhpA:
undetectable		 5x1fC-2qhpA:
21.57
5x1fJ-2qhpA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		4 LEU A 103
PHE A 102
LEU A 109
PHE A 113
 None
 1.22A 5x1fC-2v95A:
undetectable
5x1fJ-2v95A:
undetectable		 5x1fC-2v95A:
20.05
5x1fJ-2v95A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25

(Homo sapiens) 		PF03801
(Ndc80_HEC)
PF08234
(Spindle_Spc25) 		4 LEU A 224
PHE A 225
LEU A 254
PHE A 258
 None
 1.19A 5x1fC-2ve7A:
undetectable
5x1fJ-2ve7A:
undetectable		 5x1fC-2ve7A:
20.06
5x1fJ-2ve7A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		4 ARG A 532
LEU A 536
PHE A 543
LEU A 501
 None
 1.12A 5x1fC-2xgoA:
undetectable
5x1fJ-2xgoA:
undetectable		 5x1fC-2xgoA:
16.90
5x1fJ-2xgoA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.03A 5x1fC-2xn6A:
undetectable
5x1fJ-2xn6A:
undetectable		 5x1fC-2xn6A:
20.83
5x1fJ-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF04146
(YTH) 		4 LEU A  40
PHE A  44
LEU A  52
PHE A  54
 None
 1.21A 5x1fC-2yu6A:
undetectable
5x1fJ-2yu6A:
undetectable		 5x1fC-2yu6A:
18.56
5x1fJ-2yu6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 424
PHE A 443
LEU A 404
PHE A 396
 None
 1.03A 5x1fC-2z66A:
undetectable
5x1fJ-2z66A:
undetectable		 5x1fC-2z66A:
21.77
5x1fJ-2z66A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b86 GENERAL
ODORANT-BINDING
PROTEIN LUSH

(Drosophila
melanogaster) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 0.95A 5x1fC-3b86A:
undetectable
5x1fJ-3b86A:
undetectable		 5x1fC-3b86A:
17.60
5x1fJ-3b86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 ARG A 144
LEU A 151
PHE A 152
LEU A 266
 None
 1.14A 5x1fC-3cttA:
undetectable
5x1fJ-3cttA:
undetectable		 5x1fC-3cttA:
14.24
5x1fJ-3cttA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ARG A 569
LEU A 575
LEU A 580
PHE A 566
 None
 1.13A 5x1fC-3e2sA:
undetectable
5x1fJ-3e2sA:
undetectable		 5x1fC-3e2sA:
18.23
5x1fJ-3e2sA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.13A 5x1fC-3evzA:
undetectable
5x1fJ-3evzA:
undetectable		 5x1fC-3evzA:
19.78
5x1fJ-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewe NUCLEOPORIN NUP85

(Saccharomyces
cerevisiae) 		PF07575
(Nucleopor_Nup85) 		4 LEU B 362
PHE B 360
LEU B 208
PHE B 204
 None
 1.18A 5x1fC-3eweB:
2.4
5x1fJ-3eweB:
undetectable		 5x1fC-3eweB:
18.94
5x1fJ-3eweB:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  63
PHE A  62
LEU A  22
PHE A  26
 None
 0.85A 5x1fC-3exnA:
undetectable
5x1fJ-3exnA:
undetectable		 5x1fC-3exnA:
23.02
5x1fJ-3exnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4a UNCHARACTERIZED
PROTEIN YGR203W

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 LEU A 121
PHE A 125
LEU A  17
PHE A  33
 None
 1.13A 5x1fC-3f4aA:
undetectable
5x1fJ-3f4aA:
undetectable		 5x1fC-3f4aA:
18.18
5x1fJ-3f4aA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		4 ARG A 129
LEU A 143
PHE A  30
LEU A 145
 None
None
SO4  A 457 ( 4.6A)
None
 1.21A 5x1fC-3gseA:
undetectable
5x1fJ-3gseA:
undetectable		 5x1fC-3gseA:
18.40
5x1fJ-3gseA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 LEU A  80
PHE A 230
LEU A 216
PHE A 212
 None
 0.94A 5x1fC-3gzgA:
undetectable
5x1fJ-3gzgA:
undetectable		 5x1fC-3gzgA:
24.09
5x1fJ-3gzgA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju5 ARGININE KINASE

(Apostichopus
japonicus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LEU A  79
PHE A  76
LEU A  25
PHE A  18
 None
 1.05A 5x1fC-3ju5A:
undetectable
5x1fJ-3ju5A:
undetectable		 5x1fC-3ju5A:
20.42
5x1fJ-3ju5A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		4 ARG A 197
LEU A 193
LEU A 211
PHE A 203
 None
 1.02A 5x1fC-3lmmA:
undetectable
5x1fJ-3lmmA:
undetectable		 5x1fC-3lmmA:
17.18
5x1fJ-3lmmA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 ARG A 172
LEU A 179
PHE A 180
LEU A 294
 None
 1.17A 5x1fC-3lppA:
undetectable
5x1fJ-3lppA:
undetectable		 5x1fC-3lppA:
13.92
5x1fJ-3lppA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 214
PHE A 218
LEU A  24
PHE A  66
 None
 1.14A 5x1fC-3m07A:
undetectable
5x1fJ-3m07A:
undetectable		 5x1fC-3m07A:
17.05
5x1fJ-3m07A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 LEU A 111
PHE A 135
LEU A  39
PHE A  63
 None
 1.18A 5x1fC-3m33A:
undetectable
5x1fJ-3m33A:
undetectable		 5x1fC-3m33A:
19.93
5x1fJ-3m33A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		4 ARG A 290
LEU A 246
LEU A 213
PHE A 209
 None
 1.16A 5x1fC-3m4uA:
undetectable
5x1fJ-3m4uA:
undetectable		 5x1fC-3m4uA:
22.98
5x1fJ-3m4uA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 LEU A 618
PHE A 621
LEU A 614
PHE A 604
 None
 1.18A 5x1fC-3m62A:
3.1
5x1fJ-3m62A:
undetectable		 5x1fC-3m62A:
12.63
5x1fJ-3m62A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A 204
PHE A 208
LEU A 187
PHE A 195
 None
None
None
EDO  A 231 (-3.8A)
 0.98A 5x1fC-3mvuA:
3.1
5x1fJ-3mvuA:
undetectable		 5x1fC-3mvuA:
20.30
5x1fJ-3mvuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8i ODORANT BINDING
PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 0.99A 5x1fC-3q8iA:
undetectable
5x1fJ-3q8iA:
undetectable		 5x1fC-3q8iA:
17.72
5x1fJ-3q8iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		4 LEU A  28
PHE A  98
LEU A 288
PHE A 287
 None
 1.19A 5x1fC-3qyjA:
undetectable
5x1fJ-3qyjA:
undetectable		 5x1fC-3qyjA:
22.86
5x1fJ-3qyjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 214
PHE A 183
LEU A 176
PHE A 205
 None
 1.21A 5x1fC-3r11A:
undetectable
5x1fJ-3r11A:
undetectable		 5x1fC-3r11A:
18.91
5x1fJ-3r11A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 0.99A 5x1fC-3rd5A:
undetectable
5x1fJ-3rd5A:
undetectable		 5x1fC-3rd5A:
21.79
5x1fJ-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 LEU A 169
PHE A 171
LEU A 199
PHE A 195
 None
 1.02A 5x1fC-3tk3A:
1.6
5x1fJ-3tk3A:
undetectable		 5x1fC-3tk3A:
18.93
5x1fJ-3tk3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjl PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		4 LEU A  28
PHE A  34
LEU A 184
PHE A  20
 None
 1.19A 5x1fC-3zjlA:
undetectable
5x1fJ-3zjlA:
undetectable		 5x1fC-3zjlA:
20.00
5x1fJ-3zjlA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE

(Pyrococcus
abyssi) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.92A 5x1fC-4a8eA:
undetectable
5x1fJ-4a8eA:
undetectable		 5x1fC-4a8eA:
19.68
5x1fJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF04153
(NOT2_3_5) 		4 LEU C 671
PHE C 673
LEU C 666
PHE C 662
 None
 1.13A 5x1fC-4c0dC:
undetectable
5x1fJ-4c0dC:
undetectable		 5x1fC-4c0dC:
22.39
5x1fJ-4c0dC:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0g CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF04153
(NOT2_3_5) 		4 LEU A 671
PHE A 673
LEU A 666
PHE A 662
 None
 1.11A 5x1fC-4c0gA:
undetectable
5x1fJ-4c0gA:
undetectable		 5x1fC-4c0gA:
19.83
5x1fJ-4c0gA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		4 LEU A 110
PHE A 114
LEU A 100
PHE A 196
 None
None
None
EPE  A1347 (-3.5A)
 1.17A 5x1fC-4d7qA:
undetectable
5x1fJ-4d7qA:
undetectable		 5x1fC-4d7qA:
19.79
5x1fJ-4d7qA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		4 LEU A 192
PHE A 228
LEU A 190
PHE A 118
 None
 1.22A 5x1fC-4dziA:
undetectable
5x1fJ-4dziA:
undetectable		 5x1fC-4dziA:
19.91
5x1fJ-4dziA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		4 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.17A 5x1fC-4e1eA:
2.8
5x1fJ-4e1eA:
undetectable		 5x1fC-4e1eA:
20.44
5x1fJ-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A 438
PHE A 432
LEU A 246
PHE A 250
 None
 0.93A 5x1fC-4eudA:
undetectable
5x1fJ-4eudA:
undetectable		 5x1fC-4eudA:
17.99
5x1fJ-4eudA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 LEU A 300
PHE A 272
LEU A 323
PHE A 332
 None
 1.04A 5x1fC-4fd0A:
undetectable
5x1fJ-4fd0A:
undetectable		 5x1fC-4fd0A:
20.25
5x1fJ-4fd0A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 LEU A 300
PHE A 272
LEU A 323
PHE A 332
 None
 1.04A 5x1fC-4fdwA:
undetectable
5x1fJ-4fdwA:
undetectable		 5x1fC-4fdwA:
19.90
5x1fJ-4fdwA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 5x1fC-4flxA:
undetectable
5x1fJ-4flxA:
undetectable		 5x1fC-4flxA:
13.49
5x1fJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 228
PHE A 230
LEU A 203
PHE A 199
 None
 0.95A 5x1fC-4j0mA:
undetectable
5x1fJ-4j0mA:
undetectable		 5x1fC-4j0mA:
16.01
5x1fJ-4j0mA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		4 ARG D   7
LEU D  26
LEU D 226
PHE D 256
 None
 1.19A 5x1fC-4mwaD:
undetectable
5x1fJ-4mwaD:
undetectable		 5x1fC-4mwaD:
22.33
5x1fJ-4mwaD:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt4 GILGAMESH, ISOFORM I

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 ARG A 298
LEU A 294
PHE A 290
LEU A 282
 None
 1.13A 5x1fC-4nt4A:
2.5
5x1fJ-4nt4A:
undetectable		 5x1fC-4nt4A:
22.09
5x1fJ-4nt4A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 272
PHE A 252
LEU A 269
PHE A 297
 None
 1.18A 5x1fC-4oaqA:
undetectable
5x1fJ-4oaqA:
undetectable		 5x1fC-4oaqA:
20.16
5x1fJ-4oaqA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ARG A 296
LEU A 506
PHE A 508
LEU A 503
 None
 0.87A 5x1fC-4pfwA:
undetectable
5x1fJ-4pfwA:
undetectable		 5x1fC-4pfwA:
19.14
5x1fJ-4pfwA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 LEU A 303
PHE A 290
LEU A 317
PHE A 273
 None
 1.05A 5x1fC-4pmzA:
undetectable
5x1fJ-4pmzA:
undetectable		 5x1fC-4pmzA:
21.81
5x1fJ-4pmzA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 LEU A 139
PHE A 135
LEU A 154
PHE A 149
 None
 1.13A 5x1fC-4po0A:
undetectable
5x1fJ-4po0A:
undetectable		 5x1fC-4po0A:
16.24
5x1fJ-4po0A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Chitinophaga
pinensis) 		PF00561
(Abhydrolase_1) 		4 LEU A  36
PHE A 101
LEU A 277
PHE A 276
 None
 1.21A 5x1fC-4pw0A:
undetectable
5x1fJ-4pw0A:
undetectable		 5x1fC-4pw0A:
23.38
5x1fJ-4pw0A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyz UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg) 		4 LEU A 622
PHE A 661
LEU A 609
PHE A 594
 None
 1.19A 5x1fC-4pyzA:
undetectable
5x1fJ-4pyzA:
undetectable		 5x1fC-4pyzA:
20.66
5x1fJ-4pyzA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 ARG A 488
LEU A 479
PHE A 475
LEU A 500
 None
 1.14A 5x1fC-4u7tA:
undetectable
5x1fJ-4u7tA:
undetectable		 5x1fC-4u7tA:
19.46
5x1fJ-4u7tA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		4 ARG A 221
LEU A 183
PHE A 205
LEU A 176
 None
 1.20A 5x1fC-4x3mA:
undetectable
5x1fJ-4x3mA:
undetectable		 5x1fC-4x3mA:
20.14
5x1fJ-4x3mA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS

(Influenza A
virus) 		no annotation 4 LEU D 179
PHE D 233
LEU D  71
PHE D 148
 None
 1.23A 5x1fC-4xnqD:
undetectable
5x1fJ-4xnqD:
undetectable		 5x1fC-4xnqD:
19.85
5x1fJ-4xnqD:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		4 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.17A 5x1fC-4xt1A:
0.0
5x1fJ-4xt1A:
undetectable		 5x1fC-4xt1A:
21.81
5x1fJ-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
PF14533
(USP7_C2) 		4 LEU A 622
PHE A 661
LEU A 609
PHE A 594
 None
 1.22A 5x1fC-4z96A:
undetectable
5x1fJ-4z96A:
undetectable		 5x1fC-4z96A:
19.42
5x1fJ-4z96A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 ARG A 261
LEU A 163
PHE A 126
LEU A 161
 None
 1.22A 5x1fC-4zajA:
2.4
5x1fJ-4zajA:
undetectable		 5x1fC-4zajA:
17.02
5x1fJ-4zajA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B 615
PHE B 616
LEU B 763
PHE B 608
 None
 1.03A 5x1fC-4zktB:
2.6
5x1fJ-4zktB:
undetectable		 5x1fC-4zktB:
10.56
5x1fJ-4zktB:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg) 		4 LEU A 622
PHE A 661
LEU A 609
PHE A 594
 LEU  A 622 ( 0.6A)
PHE  A 661 ( 1.3A)
LEU  A 609 ( 0.6A)
PHE  A 594 ( 1.3A)
 1.19A 5x1fC-5c6dA:
undetectable
5x1fJ-5c6dA:
undetectable		 5x1fC-5c6dA:
19.21
5x1fJ-5c6dA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG

(Homo sapiens) 		PF00632
(HECT) 		4 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.00A 5x1fC-5c7mA:
undetectable
5x1fJ-5c7mA:
undetectable		 5x1fC-5c7mA:
19.45
5x1fJ-5c7mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 LEU A  81
PHE A  84
LEU A  77
PHE A  91
 None
 1.22A 5x1fC-5dnwA:
undetectable
5x1fJ-5dnwA:
undetectable		 5x1fC-5dnwA:
21.77
5x1fJ-5dnwA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		4 LEU A 441
PHE A 442
LEU A 379
PHE A 474
 None
 1.16A 5x1fC-5do7A:
3.0
5x1fJ-5do7A:
undetectable		 5x1fC-5do7A:
16.82
5x1fJ-5do7A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 394
PHE A 396
LEU A 131
PHE A 135
 None
 1.08A 5x1fC-5du3A:
undetectable
5x1fJ-5du3A:
undetectable		 5x1fC-5du3A:
21.65
5x1fJ-5du3A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e32 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 179
PHE A 233
LEU A  71
PHE A 148
 None
 1.23A 5x1fC-5e32A:
undetectable
5x1fJ-5e32A:
undetectable		 5x1fC-5e32A:
20.47
5x1fJ-5e32A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		4 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 1.00A 5x1fC-5fn3B:
2.1
5x1fJ-5fn3B:
undetectable		 5x1fC-5fn3B:
20.04
5x1fJ-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu6 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF04153
(NOT2_3_5) 		4 LEU C 671
PHE C 673
LEU C 666
PHE C 662
 None
 0.98A 5x1fC-5fu6C:
undetectable
5x1fJ-5fu6C:
undetectable		 5x1fC-5fu6C:
18.59
5x1fJ-5fu6C:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		4 LEU A  63
PHE A 290
LEU A 310
PHE A  58
 None
None
None
HEM  A 501 (-4.8A)
 1.20A 5x1fC-5gnmA:
undetectable
5x1fJ-5gnmA:
undetectable		 5x1fC-5gnmA:
21.04
5x1fJ-5gnmA:
8.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		4 ARG C 156
LEU C 160
PHE C 164
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
None
 0.22A 5x1fC-5iy5C:
36.7
5x1fJ-5iy5C:
undetectable		 5x1fC-5iy5C:
100.00
5x1fJ-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 LEU A 365
PHE A 523
LEU A 367
PHE A 355
 None
 1.22A 5x1fC-5jozA:
undetectable
5x1fJ-5jozA:
undetectable		 5x1fC-5jozA:
18.59
5x1fJ-5jozA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		4 LEU A  75
PHE A 189
LEU A 163
PHE A 125
 None
 1.05A 5x1fC-5jxuA:
undetectable
5x1fJ-5jxuA:
undetectable		 5x1fC-5jxuA:
20.49
5x1fJ-5jxuA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 ARG A 138
LEU A 142
PHE A 146
PHE A 177
 None
 1.13A 5x1fC-5k04A:
undetectable
5x1fJ-5k04A:
undetectable		 5x1fC-5k04A:
16.13
5x1fJ-5k04A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Rattus
norvegicus) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		4 LEU A 670
PHE A 617
LEU A 668
PHE A 664
 None
 1.18A 5x1fC-5k7lA:
4.4
5x1fJ-5k7lA:
undetectable		 5x1fC-5k7lA:
14.96
5x1fJ-5k7lA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 ARG A 235
LEU A 232
PHE A 229
LEU A 311
 None
 1.19A 5x1fC-5t1pA:
undetectable
5x1fJ-5t1pA:
undetectable		 5x1fC-5t1pA:
22.49
5x1fJ-5t1pA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans) 		PF03332
(PMM) 		4 LEU A  14
PHE A  47
LEU A  12
PHE A 205
 None
 1.22A 5x1fC-5ue7A:
undetectable
5x1fJ-5ue7A:
undetectable		 5x1fC-5ue7A:
21.03
5x1fJ-5ue7A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulu CADHERIN-23

(Mus musculus) 		no annotation 4 LEU A2032
PHE A2033
LEU A1955
PHE A1987
 None
 1.14A 5x1fC-5uluA:
undetectable
5x1fJ-5uluA:
undetectable		 5x1fC-5uluA:
undetectable
5x1fJ-5uluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
PF01801
(Cytomega_gL) 		4 LEU B 221
PHE B 222
LEU A 106
PHE B 174
 None
 1.07A 5x1fC-5vocB:
undetectable
5x1fJ-5vocB:
undetectable		 5x1fC-5vocB:
19.32
5x1fJ-5vocB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		4 ARG A1087
LEU A1027
PHE A1028
LEU A1114
 None
 1.21A 5x1fC-5xeiA:
4.5
5x1fJ-5xeiA:
undetectable		 5x1fC-5xeiA:
17.16
5x1fJ-5xeiA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		4 LEU A 610
PHE A 611
LEU A 742
PHE A 734
 None
 1.14A 5x1fC-5xmcA:
undetectable
5x1fJ-5xmcA:
undetectable		 5x1fC-5xmcA:
15.72
5x1fJ-5xmcA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 4 LEU C 435
PHE C 434
LEU C 418
PHE C 417
 None
 1.16A 5x1fC-6c08C:
2.3
5x1fJ-6c08C:
undetectable		 5x1fC-6c08C:
undetectable
5x1fJ-6c08C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ARG A2301
LEU A2298
PHE A2297
LEU A2450
 None
 1.19A 5x1fC-6fb3A:
undetectable
5x1fJ-6fb3A:
undetectable		 5x1fC-6fb3A:
undetectable
5x1fJ-6fb3A:
undetectable