SIMILAR PATTERNS OF AMINO ACIDS FOR 5X1B_P_CHDP306_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqb | PROTEIN (AUREOLYSIN) (Staphylococcusaureus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | THR A 77TYR A 78TRP A 117HIS A 148 | NoneNoneNone ZN A 350 (-3.3A) | 1.21A | 5x1bN-1bqbA:0.55x1bP-1bqbA:0.1 | 5x1bN-1bqbA:20.965x1bP-1bqbA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpy | SERINECARBOXYPEPTIDASE (Saccharomycescerevisiae) |
PF00450(Peptidase_S10) | 4 | ASP A 180THR A 179TYR A 316HIS A 397 | None | 1.33A | 5x1bN-1cpyA:0.05x1bP-1cpyA:0.3 | 5x1bN-1cpyA:20.455x1bP-1cpyA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1i | META CLEAVAGECOMPOUND HYDROLASE (Janthinobacterium) |
PF12697(Abhydrolase_6) | 4 | ASP A 72THR A 28TYR A 30HIS A 96 | None | 1.45A | 5x1bN-1j1iA:0.05x1bP-1j1iA:undetectable | 5x1bN-1j1iA:20.045x1bP-1j1iA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js4 | ENDO/EXOCELLULASE E4 (Thermobifidafusca) |
PF00759(Glyco_hydro_9)PF00942(CBM_3) | 4 | HIS A 108ASP A 190TYR A 192HIS A 181 | None | 1.44A | 5x1bN-1js4A:2.15x1bP-1js4A:1.8 | 5x1bN-1js4A:22.635x1bP-1js4A:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lur | ALDOSE 1-EPIMERASE (Caenorhabditiselegans) |
PF01263(Aldose_epim) | 4 | HIS A1163ASP A1276TYR A1285HIS A1092 | None | 0.93A | 5x1bN-1lurA:undetectable5x1bP-1lurA:undetectable | 5x1bN-1lurA:21.015x1bP-1lurA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n81 | PLASMODIUMFALCIPARUM GAMETEANTIGEN 27/25 (Plasmodiumfalciparum) |
PF09216(Pfg27) | 4 | ASP A 164THR A 165TYR A 168HIS A 28 | None | 1.45A | 5x1bN-1n81A:0.85x1bP-1n81A:0.8 | 5x1bN-1n81A:14.405x1bP-1n81A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | HIS A 280ASP A 222THR A 223TYR A 201 | None | 1.26A | 5x1bN-1nj1A:0.05x1bP-1nj1A:0.0 | 5x1bN-1nj1A:20.075x1bP-1nj1A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw1 | CHOLINE KINASE (49.2KD) (Caenorhabditiselegans) |
PF01633(Choline_kinase) | 4 | HIS A 384ASP A 324TYR A 333HIS A 418 | None | 1.28A | 5x1bN-1nw1A:2.05x1bP-1nw1A:0.0 | 5x1bN-1nw1A:21.485x1bP-1nw1A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1snz | ALDOSE 1-EPIMERASE (Homo sapiens) |
PF01263(Aldose_epim) | 4 | HIS A 176ASP A 287TYR A 298HIS A 107 | None | 1.23A | 5x1bN-1snzA:undetectable5x1bP-1snzA:undetectable | 5x1bN-1snzA:19.695x1bP-1snzA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | HIS A 285ASP A 327THR A 329HIS A 267 | None | 1.07A | 5x1bN-1vknA:undetectable5x1bP-1vknA:0.0 | 5x1bN-1vknA:21.355x1bP-1vknA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfd | DIPEPTIDYLAMINOPEPTIDASE-LIKEPROTEIN 6 (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | ASP A 712TYR A 716TRP A 429HIS A 431 | None | 1.05A | 5x1bN-1xfdA:undetectable5x1bP-1xfdA:undetectable | 5x1bN-1xfdA:19.955x1bP-1xfdA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysj | PROTEIN YXEP (Bacillussubtilis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | HIS A 158ASP A 357THR A 343HIS A 100 | NI A 381 (-3.4A)NoneNone NI A 381 (-3.2A) | 1.28A | 5x1bN-1ysjA:undetectable5x1bP-1ysjA:undetectable | 5x1bN-1ysjA:19.865x1bP-1ysjA:22.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2eij | CYTOCHROME C OXIDASESUBUNIT 1 (Bos taurus) |
PF00115(COX1) | 4 | HIS A 233ASP A 300THR A 301TYR A 304 | None | 0.18A | 5x1bN-2eijA:63.15x1bP-2eijA:2.7 | 5x1bN-2eijA:100.005x1bP-2eijA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4o | PEPTIDE N-GLYCANASE (Mus musculus) |
PF01841(Transglut_core) | 4 | ASP A 332THR A 331TYR A 330TRP A 386 | None | 1.29A | 5x1bN-2f4oA:undetectable5x1bP-2f4oA:undetectable | 5x1bN-2f4oA:16.315x1bP-2f4oA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gs4 | PROTEIN YCIF (Escherichiacoli) |
PF05974(DUF892) | 4 | ASP A 16THR A 17TYR A 18HIS A 47 | None | 1.20A | 5x1bN-2gs4A:3.35x1bP-2gs4A:3.8 | 5x1bN-2gs4A:14.175x1bP-2gs4A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hyp | HYPOTHETICAL PROTEINRV0805 (Mycobacteriumtuberculosis) |
PF00149(Metallophos) | 4 | HIS A 261ASP A 257THR A 258TYR A 255 | None BR A 302 (-4.7A) BR A 302 ( 4.9A)None | 1.32A | 5x1bN-2hypA:undetectable5x1bP-2hypA:undetectable | 5x1bN-2hypA:20.495x1bP-2hypA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3x | POLYPHENOL OXIDASE,CHLOROPLAST (Vitis vinifera) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 4 | HIS A 243ASP A 181TYR A 182HIS A 272 | C2O A 340 (-3.3A)NoneNoneC2O A 340 (-3.1A) | 1.47A | 5x1bN-2p3xA:undetectable5x1bP-2p3xA:undetectable | 5x1bN-2p3xA:19.175x1bP-2p3xA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfz | TBC1 DOMAIN FAMILYMEMBER 22A (Homo sapiens) |
PF00566(RabGAP-TBC) | 4 | ASP A 275THR A 276TYR A 277HIS A 313 | None | 1.45A | 5x1bN-2qfzA:2.45x1bP-2qfzA:undetectable | 5x1bN-2qfzA:19.665x1bP-2qfzA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vqr | PUTATIVE SULFATASE (Rhizobiumleguminosarum) |
PF00884(Sulfatase)PF16347(DUF4976) | 4 | HIS A 411ASP A 482TYR A 447HIS A 494 | None | 1.30A | 5x1bN-2vqrA:undetectable5x1bP-2vqrA:undetectable | 5x1bN-2vqrA:20.485x1bP-2vqrA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vyc | BIODEGRADATIVEARGININEDECARBOXYLASE (Escherichiacoli) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 4 | HIS A 382ASP A 362TYR A 360HIS A 398 | None | 1.43A | 5x1bN-2vycA:undetectable5x1bP-2vycA:undetectable | 5x1bN-2vycA:21.375x1bP-2vycA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8s | PHOSPHONATEMONOESTER HYDROLASE (Paraburkholderiacaryophylli) |
PF00884(Sulfatase)PF16347(DUF4976) | 4 | HIS A 411ASP A 482TYR A 447HIS A 494 | NoneNoneNoneSO4 A1517 (-4.1A) | 1.28A | 5x1bN-2w8sA:undetectable5x1bP-2w8sA:undetectable | 5x1bN-2w8sA:19.335x1bP-2w8sA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1b | CARBONIC ANHYDRASE 1 (Chlamydomonasreinhardtii) |
PF00194(Carb_anhydrase) | 4 | HIS A 271ASP A 153TRP A 93HIS A 185 | None | 1.35A | 5x1bN-3b1bA:undetectable5x1bP-3b1bA:undetectable | 5x1bN-3b1bA:22.985x1bP-3b1bA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d23 | 3C-LIKE PROTEINASE (HumancoronavirusHKU1) |
no annotation | 4 | HIS B 41ASP B 176THR B 175TYR B 161 | None | 1.29A | 5x1bN-3d23B:undetectable5x1bP-3d23B:undetectable | 5x1bN-3d23B:20.695x1bP-3d23B:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ec7 | PUTATIVEDEHYDROGENASE (Salmonellaenterica) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | HIS A 176ASP A 277TYR A 129HIS A 155 | EPE A 401 (-4.0A)NoneNoneEPE A 401 (-4.4A) | 1.08A | 5x1bN-3ec7A:undetectable5x1bP-3ec7A:undetectable | 5x1bN-3ec7A:20.735x1bP-3ec7A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecn | HIGH AFFINITYCAMP-SPECIFIC ANDIBMX-INSENSITIVE3',5'-CYCLICPHOSPHODIESTERASE 8A (Homo sapiens) |
PF00233(PDEase_I) | 4 | ASP A 621THR A 622TYR A 619HIS A 676 | None | 1.36A | 5x1bN-3ecnA:undetectable5x1bP-3ecnA:undetectable | 5x1bN-3ecnA:18.325x1bP-3ecnA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnr | OS03G0212800 PROTEIN (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | HIS A 219ASP A 304THR A 302HIS A 220 | HIS A 219 ( 1.0A)ASP A 304 ( 0.6A)THR A 302 ( 0.8A)HIS A 220 ( 1.0A) | 1.46A | 5x1bN-3gnrA:undetectable5x1bP-3gnrA:undetectable | 5x1bN-3gnrA:21.635x1bP-3gnrA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib7 | ICC PROTEIN (Mycobacteriumtuberculosis) |
PF00149(Metallophos) | 4 | HIS A 261ASP A 257THR A 258TYR A 255 | None | 1.44A | 5x1bN-3ib7A:undetectable5x1bP-3ib7A:undetectable | 5x1bN-3ib7A:23.255x1bP-3ib7A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ig4 | XAA-PROAMINOPEPTIDASE (Bacillusanthracis) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 4 | HIS A 350ASP A 385THR A 367HIS A 239 | SO4 A 430 (-3.6A)None MN A 429 ( 4.6A)SO4 A 431 ( 3.4A) | 1.33A | 5x1bN-3ig4A:undetectable5x1bP-3ig4A:2.2 | 5x1bN-3ig4A:21.635x1bP-3ig4A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3izq | ELONGATION FACTOR 1ALPHA-LIKE PROTEIN (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF08938(HBS1_N) | 4 | ASP 1 366THR 1 365TYR 1 364HIS 1 243 | None | 1.41A | 5x1bN-3izq1:undetectable5x1bP-3izq1:undetectable | 5x1bN-3izq1:20.065x1bP-3izq1:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j97 | ALPHA-SOLUBLE NSFATTACHMENT PROTEIN (Rattusnorvegicus) |
no annotation | 4 | HIS H 124ASP H 113THR H 112HIS H 144 | None | 1.21A | 5x1bN-3j97H:2.75x1bP-3j97H:4.8 | 5x1bN-3j97H:19.265x1bP-3j97H:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi6 | ALPHA-GALACTOSIDASE (Lactobacillusbrevis) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 4 | ASP A 642THR A 652TYR A 669HIS A 205 | None | 1.27A | 5x1bN-3mi6A:undetectable5x1bP-3mi6A:undetectable | 5x1bN-3mi6A:21.285x1bP-3mi6A:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn8 | LP15968P (Drosophilamelanogaster) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 4 | ASP A 257THR A 254TYR A 255HIS A 336 | None | 1.48A | 5x1bN-3mn8A:undetectable5x1bP-3mn8A:undetectable | 5x1bN-3mn8A:23.475x1bP-3mn8A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | ASP A 115THR A 114TYR A 113HIS A 337 | NoneNoneNoneADN A 500 ( 3.6A) | 1.24A | 5x1bN-3n58A:undetectable5x1bP-3n58A:undetectable | 5x1bN-3n58A:21.155x1bP-3n58A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nad | FERULATEDECARBOXYLASE (Bacilluspumilus) |
PF05870(PA_decarbox) | 4 | ASP A 129THR A 12TYR A 13HIS A 8 | None | 1.45A | 5x1bN-3nadA:undetectable5x1bP-3nadA:undetectable | 5x1bN-3nadA:13.515x1bP-3nadA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qbw | ANHYDRO-N-ACETYLMURAMIC ACID KINASE (Pseudomonasaeruginosa) |
PF03702(AnmK) | 4 | HIS A 147ASP A 316THR A 315TYR A 318 | None | 1.14A | 5x1bN-3qbwA:undetectable5x1bP-3qbwA:undetectable | 5x1bN-3qbwA:21.435x1bP-3qbwA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sp1 | CYSTEINYL-TRNASYNTHETASE (Borreliellaburgdorferi) |
PF01406(tRNA-synt_1e) | 4 | HIS A 246ASP A 68THR A 67HIS A 236 | ZN A 481 (-3.3A)NoneNoneNone | 1.37A | 5x1bN-3sp1A:undetectable5x1bP-3sp1A:undetectable | 5x1bN-3sp1A:20.435x1bP-3sp1A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vte | TETRAHYDROCANNABINOLIC ACID SYNTHASE (Cannabis sativa) |
PF01565(FAD_binding_4)PF08031(BBE) | 4 | HIS A 318ASP A 349THR A 350TYR A 354 | None | 1.30A | 5x1bN-3vteA:undetectable5x1bP-3vteA:undetectable | 5x1bN-3vteA:20.625x1bP-3vteA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4el8 | GLYCOSIDE HYDROLASEFAMILY 48 (Caldicellulosiruptorbescii) |
PF02011(Glyco_hydro_48) | 4 | HIS A 191ASP A 223THR A 222TYR A 221 | None | 1.14A | 5x1bN-4el8A:1.75x1bP-4el8A:1.2 | 5x1bN-4el8A:20.225x1bP-4el8A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmg | IRON-REGULATEDTRANSCRIPTIONALACTIVATOR AFT2 (Saccharomycescerevisiae) |
PF08731(AFT) | 4 | ASP A 146THR A 145TYR A 148HIS A 135 | NoneNoneNone ZN A 201 (-3.2A) | 1.34A | 5x1bN-4lmgA:undetectable5x1bP-4lmgA:undetectable | 5x1bN-4lmgA:13.375x1bP-4lmgA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lq1 | 1,4-ALPHA-GLUCANBRANCHING ENZYMEGLGB (Escherichiacoli) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 4 | ASP A 491THR A 489TYR A 492TRP A 628 | None | 1.47A | 5x1bN-4lq1A:undetectable5x1bP-4lq1A:undetectable | 5x1bN-4lq1A:21.785x1bP-4lq1A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1a | CELLDIVISIONFTSK/SPOIIIE (Thermomonosporacurvata) |
PF01580(FtsK_SpoIIIE) | 4 | HIS A 877ASP A 790THR A 788TYR A 787 | None | 1.40A | 5x1bN-4n1aA:undetectable5x1bP-4n1aA:undetectable | 5x1bN-4n1aA:21.755x1bP-4n1aA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nh0 | CELLDIVISIONFTSK/SPOIIIE (Thermomonosporacurvata) |
PF01580(FtsK_SpoIIIE) | 4 | HIS A 877ASP A 790THR A 788TYR A 787 | None | 1.44A | 5x1bN-4nh0A:undetectable5x1bP-4nh0A:undetectable | 5x1bN-4nh0A:17.505x1bP-4nh0A:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p62 | METALLO-BETA-LACTAMASE AIM-1 (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 4 | HIS A 106ASP A 132THR A 133HIS A 182 | ZN A 301 (-3.1A)NoneNone ZN A 301 (-3.3A) | 1.48A | 5x1bN-4p62A:1.15x1bP-4p62A:undetectable | 5x1bN-4p62A:20.005x1bP-4p62A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 4 | HIS A 387ASP A 214THR A 213HIS A 389 | HEM A 602 (-3.7A)NoneHEM A 602 (-3.4A)HEM A 602 (-3.3A) | 1.26A | 5x1bN-4ph9A:undetectable5x1bP-4ph9A:undetectable | 5x1bN-4ph9A:20.295x1bP-4ph9A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6u | UNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
no annotation | 4 | ASP A 114THR A 113TYR A 132HIS A 198 | 1PE A 401 (-3.2A)NoneNoneNone | 1.48A | 5x1bN-4q6uA:undetectable5x1bP-4q6uA:undetectable | 5x1bN-4q6uA:21.765x1bP-4q6uA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkt | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | ASP A3187THR A3196TYR A3197HIS A3352 | None | 1.42A | 5x1bN-4tktA:undetectable5x1bP-4tktA:undetectable | 5x1bN-4tktA:21.345x1bP-4tktA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tn0 | UPF0141 PROTEIN YJDB (Campylobacterjejuni) |
PF00884(Sulfatase) | 4 | ASP A 402THR A 401TYR A 400HIS A 428 | NoneNoneNone ZN A 601 (-3.4A) | 1.33A | 5x1bN-4tn0A:undetectable5x1bP-4tn0A:undetectable | 5x1bN-4tn0A:21.765x1bP-4tn0A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xly | UNCHARACTERIZEDPROTEIN BLR2150 (Bradyrhizobiumdiazoefficiens) |
no annotation | 4 | ASP A 132THR A 133TYR A 136TRP A 14 | NoneNoneECP A 700 ( 4.9A)None | 1.03A | 5x1bN-4xlyA:1.95x1bP-4xlyA:2.2 | 5x1bN-4xlyA:19.805x1bP-4xlyA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjq | CARBOHYDRATE BINDINGPROTEIN, PUTATIVE,CPB33A (Cellvibriojaponicus) |
PF03067(LPMO_10) | 4 | HIS A 178ASP A 198THR A 138HIS A 165 | None | 1.26A | 5x1bN-5fjqA:undetectable5x1bP-5fjqA:undetectable | 5x1bN-5fjqA:14.545x1bP-5fjqA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftz | CHITIN BINDINGPROTEIN (Streptomyceslividans) |
PF03067(LPMO_10) | 4 | HIS A 120ASP A 124TYR A 155HIS A 30 | CU A 202 (-3.1A)NoneNone CU A 202 (-2.9A) | 1.33A | 5x1bN-5ftzA:undetectable5x1bP-5ftzA:undetectable | 5x1bN-5ftzA:16.945x1bP-5ftzA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 4 | HIS A 386ASP A 213THR A 212HIS A 388 | COH A 602 (-3.7A)NoneCOH A 602 (-2.4A)COH A 602 (-3.3A) | 1.16A | 5x1bN-5ikrA:undetectable5x1bP-5ikrA:undetectable | 5x1bN-5ikrA:21.045x1bP-5ikrA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oko | PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE5-PHOSPHATASE 2 (Homo sapiens) |
PF03372(Exo_endo_phos) | 4 | HIS A 674ASP A 669THR A 670TYR A 671 | None | 1.26A | 5x1bN-5okoA:undetectable5x1bP-5okoA:undetectable | 5x1bN-5okoA:22.945x1bP-5okoA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tir | SUPEROXIDE DISMUTASE (Trichodermareesei) |
no annotation | 4 | HIS A 30ASP A 16TYR A 13HIS A 34 | MN A 301 (-3.4A)NoneNoneNone | 1.45A | 5x1bN-5tirA:undetectable5x1bP-5tirA:2.1 | 5x1bN-5tirA:19.465x1bP-5tirA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y2v | RUBISCO OPERONTRANSCRIPTIONALREGULATOR (Synechocystissp. PCC 6803) |
no annotation | 4 | HIS A 0ASP A 72THR A 69HIS A -1 | None | 1.24A | 5x1bN-5y2vA:undetectable5x1bP-5y2vA:undetectable | 5x1bN-5y2vA:undetectable5x1bP-5y2vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9d | ACYL-COENZYME AOXIDASE 1 (Yarrowialipolytica) |
no annotation | 4 | ASP A 519THR A 518TYR A 521HIS A 548 | None | 1.10A | 5x1bN-5y9dA:2.25x1bP-5y9dA:2.2 | 5x1bN-5y9dA:undetectable5x1bP-5y9dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b74 | COAGULATION FACTORXII (Homo sapiens) |
no annotation | 4 | HIS B 57ASP B 230THR B 229TYR B 228 | SO4 B 304 (-3.8A)NoneNoneNone | 1.41A | 5x1bN-6b74B:undetectable5x1bP-6b74B:undetectable | 5x1bN-6b74B:undetectable5x1bP-6b74B:undetectable |