SIMILAR PATTERNS OF AMINO ACIDS FOR 5X19_P_CHDP305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE


(Megasphaera
elsdenii)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
None
0.96A 5x19P-1bucA:
3.5
5x19P-1bucA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE


(Salmonella
enterica)
PF00797
(Acetyltransf_2)
4 ARG A  88
LEU A  90
PHE A 174
LEU A 176
None
1.02A 5x19P-1e2tA:
undetectable
5x19P-1e2tA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE


(Paraburkholderia
xenovorans)
PF00355
(Rieske)
4 LYS A  87
LEU A  86
PHE A  70
LEU A  50
None
0.97A 5x19P-1fqtA:
undetectable
5x19P-1fqtA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens)
PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2)
4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
None
0.85A 5x19P-1jkwA:
0.7
5x19P-1jkwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE


(Bos taurus)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 LEU A  57
PHE A  61
PHE A  27
LEU A  35
None
1.07A 5x19P-1lamA:
0.0
5x19P-1lamA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 LEU A  31
PHE A  27
PHE A  93
LEU A  56
None
1.06A 5x19P-1mdfA:
undetectable
5x19P-1mdfA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpy CATECHOL
2,3-DIOXYGENASE


(Pseudomonas
putida)
PF00903
(Glyoxalase)
4 LEU A 119
PHE A 117
PHE A 109
LEU A  85
None
1.18A 5x19P-1mpyA:
undetectable
5x19P-1mpyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE


(Plasmodium
falciparum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LYS A 173
LEU A  76
PHE A  74
LEU A 197
None
1.03A 5x19P-1onfA:
undetectable
5x19P-1onfA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE


(Sus scrofa)
PF02971
(FTCD)
PF07837
(FTCD_N)
4 LEU A 246
PHE A 250
PHE A 185
LEU A 269
None
0.94A 5x19P-1qd1A:
undetectable
5x19P-1qd1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qql FIBROBLAST GROWTH
FACTOR 7/1 CHIMERA


(Homo sapiens;
Rattus
norvegicus)
PF00167
(FGF)
4 LYS A 112
LEU A 111
PHE A 132
LEU A  23
None
1.12A 5x19P-1qqlA:
undetectable
5x19P-1qqlA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suj CONE ARRESTIN

(Ambystoma
tigrinum)
PF00339
(Arrestin_N)
PF02752
(Arrestin_C)
4 LYS A 144
LEU A 163
PHE A 369
LEU A  21
None
1.22A 5x19P-1sujA:
undetectable
5x19P-1sujA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
4 LYS A 152
LEU A 153
PHE A 156
LEU A 125
None
1.09A 5x19P-1ua2A:
1.8
5x19P-1ua2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhf PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN


(Thermotoga
maritima)
PF03091
(CutA1)
4 LEU A  21
PHE A  30
PHE A  55
LEU A  69
None
1.09A 5x19P-1vhfA:
undetectable
5x19P-1vhfA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I


(Thermoproteus
tenax)
PF01791
(DeoC)
4 LYS A 215
LEU A 214
PHE A 243
LEU A 247
None
1.05A 5x19P-1w8sA:
undetectable
5x19P-1w8sA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yln HYPOTHETICAL PROTEIN
VCA0042


(Vibrio cholerae)
PF07238
(PilZ)
PF12945
(YcgR_2)
4 LYS A 205
LEU A 220
PHE A 170
LEU A 187
None
1.16A 5x19P-1ylnA:
undetectable
5x19P-1ylnA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT


(Lactococcus
lactis)
PF13393
(tRNA-synt_His)
4 LEU A 236
PHE A 240
PHE A 168
LEU A 172
None
0.69A 5x19P-1z7mA:
undetectable
5x19P-1z7mA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvf 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE


(Saccharomyces
cerevisiae)
PF06052
(3-HAO)
4 LYS A  67
LEU A  66
PHE A  57
LEU A  91
None
1.16A 5x19P-1zvfA:
undetectable
5x19P-1zvfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atp T-CELL SURFACE
GLYCOPROTEIN CD8
ALPHA CHAIN


(Mus musculus)
PF07686
(V-set)
4 LYS A  68
LEU A  69
PHE A  75
LEU A  74
None
1.17A 5x19P-2atpA:
undetectable
5x19P-2atpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnd NADH-DEPENDENT
NITRATE REDUCTASE


(Zea mays)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 LEU A  34
PHE A  32
PHE A  76
LEU A  41
None
1.21A 5x19P-2cndA:
undetectable
5x19P-2cndA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edz PDZ
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
PF00595
(PDZ)
4 LYS A  18
LEU A  19
PHE A  29
LEU A  56
None
1.13A 5x19P-2edzA:
undetectable
5x19P-2edzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA


(Homo sapiens)
no annotation 4 LEU I 319
PHE I 257
PHE I 305
LEU I 359
None
1.18A 5x19P-2gk1I:
undetectable
5x19P-2gk1I:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF00440
(TetR_N)
4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
None
0.88A 5x19P-2ibdA:
undetectable
5x19P-2ibdA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2


(Homo sapiens)
PF02174
(IRS)
4 LYS A  20
PHE A  89
PHE A  72
LEU A 101
None
1.16A 5x19P-2mfqA:
undetectable
5x19P-2mfqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE


(Homo sapiens)
PF01053
(Cys_Met_Meta_PP)
4 LEU A  78
PHE A  15
PHE A  18
LEU A 262
None
1.03A 5x19P-2nmpA:
undetectable
5x19P-2nmpA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
None
0.62A 5x19P-2optA:
3.0
5x19P-2optA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE


(Bacillus
anthracis)
PF01678
(DAP_epimerase)
4 ARG A  81
LYS A 271
LEU A 258
LEU A  12
None
0.69A 5x19P-2otnA:
undetectable
5x19P-2otnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron)
PF00294
(PfkB)
4 LYS A 175
LEU A 174
PHE A 168
LEU A 202
None
None
EDO  A 298 ( 4.9A)
EDO  A 298 (-4.9A)
1.02A 5x19P-2qhpA:
undetectable
5x19P-2qhpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii)
PF01823
(MACPF)
5 LYS A 335
LEU A 338
PHE A 342
PHE A 195
LEU A 194
None
1.26A 5x19P-2qp2A:
undetectable
5x19P-2qp2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 LYS A 106
LEU A 109
PHE A 115
LEU A 176
None
0.90A 5x19P-2wrdA:
undetectable
5x19P-2wrdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 LYS A 440
LEU A 441
PHE A 356
LEU A 396
None
1.22A 5x19P-2x40A:
undetectable
5x19P-2x40A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris)
PF13432
(TPR_16)
PF13844
(Glyco_transf_41)
4 ARG A 532
LEU A 536
PHE A 543
LEU A 501
None
1.01A 5x19P-2xgoA:
undetectable
5x19P-2xgoA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Prochlorococcus
marinus)
PF00148
(Oxidored_nitro)
4 LEU C  35
PHE C  60
PHE C  33
LEU C  87
None
1.02A 5x19P-2ynmC:
undetectable
5x19P-2ynmC:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus)
PF01261
(AP_endonuc_2)
4 LEU A 247
PHE A 245
PHE A 263
LEU A 222
None
1.12A 5x19P-3aamA:
undetectable
5x19P-3aamA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Rhodobacter
capsulatus)
PF00148
(Oxidored_nitro)
4 LEU A  44
PHE A  69
PHE A  42
LEU A  96
None
1.01A 5x19P-3aeuA:
undetectable
5x19P-3aeuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 ARG A 144
LEU A 151
PHE A 152
LEU A 266
None
1.05A 5x19P-3cttA:
undetectable
5x19P-3cttA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
4 LEU C 299
PHE C 338
PHE C 310
LEU C 355
None
1.09A 5x19P-3degC:
undetectable
5x19P-3degC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl0 ADENYLATE KINASE

(Bacillus
subtilis)
PF00406
(ADK)
PF05191
(ADK_lid)
4 LYS A  69
LEU A  72
PHE A  81
LEU A  83
None
1.12A 5x19P-3dl0A:
undetectable
5x19P-3dl0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens)
PF00067
(p450)
4 LYS A 461
LEU A 460
PHE A 458
LEU A 312
None
1.12A 5x19P-3e4eA:
1.3
5x19P-3e4eA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN


(Aeropyrum
pernix)
PF13458
(Peripla_BP_6)
4 LYS A 362
LEU A 365
PHE A 370
LEU A 340
None
1.23A 5x19P-3eafA:
undetectable
5x19P-3eafA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE


(Salmonella
enterica)
PF00152
(tRNA-synt_2)
4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
None
0.87A 5x19P-3g1zA:
undetectable
5x19P-3g1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrt METALLOREGULATOR
SCAR


(Streptococcus
gordonii)
PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA)
4 ARG A  74
LYS A  75
LEU A  78
PHE A  82
None
0.66A 5x19P-3hrtA:
undetectable
5x19P-3hrtA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster)
no annotation 4 LYS B 233
LEU B 232
PHE B 285
LEU B 281
None
1.05A 5x19P-3k1lB:
undetectable
5x19P-3k1lB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA


(Methylobacillus
flagellatus)
PF08886
(GshA)
4 ARG A 400
LEU A  14
PHE A  54
LEU A   6
None
1.21A 5x19P-3k1tA:
undetectable
5x19P-3k1tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile)
PF01170
(UPF0020)
PF02926
(THUMP)
4 LYS A 359
LEU A 360
PHE A  11
LEU A 184
None
1.13A 5x19P-3lduA:
undetectable
5x19P-3lduA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llb UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF03471
(CorC_HlyC)
4 LEU A  58
PHE A  61
PHE A  30
LEU A  41
None
1.23A 5x19P-3llbA:
undetectable
5x19P-3llbA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 ARG A 172
LEU A 179
PHE A 180
LEU A 294
None
1.11A 5x19P-3lppA:
undetectable
5x19P-3lppA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
4 LYS A   4
LEU A   7
PHE A  18
LEU A  22
None
1.05A 5x19P-3m6xA:
undetectable
5x19P-3m6xA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nre ALDOSE 1-EPIMERASE

(Escherichia
coli)
PF01263
(Aldose_epim)
4 LEU A 153
PHE A 151
PHE A 250
LEU A 194
None
1.19A 5x19P-3nreA:
undetectable
5x19P-3nreA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00266
(Aminotran_5)
4 LEU A 350
PHE A   5
PHE A   7
LEU A 325
None
1.19A 5x19P-3qm2A:
undetectable
5x19P-3qm2A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium)
PF00106
(adh_short)
4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
None
0.96A 5x19P-3rd5A:
undetectable
5x19P-3rd5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus)
PF00506
(Flu_NP)
4 ARG A 411
LEU A 384
PHE A 385
PHE A 419
None
1.18A 5x19P-3tj0A:
3.4
5x19P-3tj0A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF10672
(Methyltrans_SAM)
4 ARG A  55
LEU A  60
PHE A  38
LEU A  32
None
1.15A 5x19P-3vseA:
undetectable
5x19P-3vseA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4y PROTEIN MXIG

(Shigella
flexneri)
PF09480
(PrgH)
4 LYS A 106
LEU A 105
PHE A 103
PHE A  79
None
0.65A 5x19P-4a4yA:
undetectable
5x19P-4a4yA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acj WU:FB25H12 PROTEIN,

(Danio rerio)
PF07534
(TLD)
4 LYS A 652
LEU A 654
PHE A 800
LEU A 691
None
1.22A 5x19P-4acjA:
undetectable
5x19P-4acjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1


(Mytilus
galloprovincialis)
PF00092
(VWA)
4 LYS A 234
LEU A 233
PHE A  79
LEU A  83
None
0.91A 5x19P-4cn8A:
undetectable
5x19P-4cn8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum)
PF00224
(PK)
PF02887
(PK_C)
4 ARG A  93
LEU A  89
PHE A 224
LEU A 230
ACT  A 607 (-4.1A)
ACT  A 607 ( 4.9A)
None
None
1.12A 5x19P-4drsA:
undetectable
5x19P-4drsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN


(Labrenzia
alexandrii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 321
PHE A  23
PHE A  25
LEU A 376
None
1.03A 5x19P-4e5tA:
undetectable
5x19P-4e5tA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
0.90A 5x19P-4flxA:
2.7
5x19P-4flxA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA


(Pseudomonas sp.
C18)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
4 LYS A 136
LEU A 135
PHE A 108
LEU A  88
None
1.22A 5x19P-4hjlA:
undetectable
5x19P-4hjlA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP


(Plasmodium
falciparum)
PF00092
(VWA)
5 ARG A 176
LYS A 173
LEU A 172
PHE A 198
LEU A 202
None
1.09A 5x19P-4hqfA:
undetectable
5x19P-4hqfA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5


(Sus scrofa)
PF00271
(Helicase_C)
4 LYS A 681
LEU A 684
PHE A 549
LEU A 553
None
0.67A 5x19P-4i1sA:
2.3
5x19P-4i1sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT


(Saccharomyces
cerevisiae)
PF01896
(DNA_primase_S)
4 ARG A  58
LYS A  57
PHE A  80
LEU A 324
None
1.14A 5x19P-4limA:
undetectable
5x19P-4limA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6q VOSA

(Aspergillus
nidulans)
PF11754
(Velvet)
4 LYS A 132
LEU A 131
PHE A 129
LEU A 121
None
0.85A 5x19P-4n6qA:
undetectable
5x19P-4n6qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
4 LEU A 636
PHE A 621
PHE A 623
LEU A 921
None
None
None
SEP  A 922 ( 4.5A)
1.17A 5x19P-4otdA:
undetectable
5x19P-4otdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN


(Legionella
pneumophila)
PF13855
(LRR_8)
5 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
None
1.46A 5x19P-4q62A:
undetectable
5x19P-4q62A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmi CYTOSKELETON-ASSOCIA
TED PROTEIN 5


(Homo sapiens)
PF12348
(CLASP_N)
4 LYS A1005
LEU A1006
PHE A1045
LEU A1016
None
1.19A 5x19P-4qmiA:
undetectable
5x19P-4qmiA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans)
PF09659
(Cas_Csm6)
4 LEU A 221
PHE A 220
PHE A  98
LEU A  86
None
0.94A 5x19P-4rgpA:
2.4
5x19P-4rgpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013)
PF12697
(Abhydrolase_6)
4 ARG A 196
LEU A 163
PHE A 185
LEU A 189
None
0.85A 5x19P-4rncA:
undetectable
5x19P-4rncA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae)
PF00079
(Serpin)
4 ARG A 384
LEU A 262
PHE A 260
PHE A 380
None
1.04A 5x19P-4roaA:
undetectable
5x19P-4roaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5j ADENYLATE KINASE

(Streptococcus
pneumoniae)
PF00406
(ADK)
4 LYS A  69
LEU A  72
PHE A  82
LEU A  84
None
1.03A 5x19P-4w5jA:
undetectable
5x19P-4w5jA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN


(Chaetomium
thermophilum)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
None
1.09A 5x19P-4wpxA:
undetectable
5x19P-4wpxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1


(Encephalitozoon
cuniculi)
no annotation 4 LYS C 281
LEU C 282
PHE C 304
LEU C 300
None
1.11A 5x19P-4wzsC:
undetectable
5x19P-4wzsC:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
4 ARG A 221
LEU A 183
PHE A 205
LEU A 176
None
1.19A 5x19P-4x3mA:
undetectable
5x19P-4x3mA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt8 RV2671

(Mycobacterium
tuberculosis)
PF01872
(RibD_C)
4 ARG A 155
LEU A 156
PHE A 133
LEU A 126
None
1.22A 5x19P-4xt8A:
undetectable
5x19P-4xt8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED


(Bacteroides
thetaiotaomicron)
PF04041
(Glyco_hydro_130)
4 LYS B 253
LEU B 254
PHE B 317
PHE B 309
None
0.86A 5x19P-5a7vB:
undetectable
5x19P-5a7vB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajh CUTINASE

(Fusarium
oxysporum)
PF01083
(Cutinase)
4 LYS A  59
LEU A  60
PHE A  37
LEU A 204
None
1.19A 5x19P-5ajhA:
undetectable
5x19P-5ajhA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2


(Rattus
norvegicus)
PF00431
(CUB)
PF07645
(EGF_CA)
4 ARG A  80
LEU A  70
PHE A 111
PHE A  42
None
1.00A 5x19P-5ckmA:
undetectable
5x19P-5ckmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82
NUCLEOPORIN NUP159


(Chaetomium
thermophilum;
Chaetomium
thermophilum)
no annotation
no annotation
4 ARG C1447
LYS C1448
LEU C1451
LEU B 425
None
0.94A 5x19P-5cwwC:
undetectable
5x19P-5cwwC:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis)
PF08659
(KR)
4 LYS A 208
PHE A 205
PHE A 159
LEU A 155
None
1.20A 5x19P-5d2eA:
undetectable
5x19P-5d2eA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens)
PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C)
4 LYS A  57
LEU A  58
PHE A  60
LEU A 182
LYS  A  57 ( 0.0A)
LEU  A  58 ( 0.6A)
PHE  A  60 ( 1.3A)
LEU  A 182 ( 0.6A)
0.91A 5x19P-5d7wA:
undetectable
5x19P-5d7wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE


(Schistosoma
mansoni)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
4 LEU A  47
PHE A  49
PHE A 207
LEU A 217
None
0.98A 5x19P-5eytA:
3.9
5x19P-5eytA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3y ADENYLATE KINSE

(synthetic
construct)
PF00406
(ADK)
PF05191
(ADK_lid)
4 LYS A  69
LEU A  72
PHE A  81
LEU A  83
None
0.84A 5x19P-5g3yA:
undetectable
5x19P-5g3yA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7


(Homo sapiens)
PF01853
(MOZ_SAS)
4 LYS A 602
LEU A 601
PHE A 493
LEU A 497
None
1.13A 5x19P-5gk9A:
undetectable
5x19P-5gk9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)


(Nostoc sp. PCC
7120)
PF02136
(NTF2)
PF09150
(Carot_N)
4 LYS A  69
LEU A  68
PHE A 109
LEU A 113
None
None
None
45D  A 501 ( 4.8A)
1.07A 5x19P-5hgrA:
undetectable
5x19P-5hgrA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2


(Planctopirus
limnophila)
PF00891
(Methyltransf_2)
PF16864
(Dimerisation2)
4 ARG A 293
LEU A 295
PHE A 173
LEU A 177
None
1.02A 5x19P-5i2hA:
undetectable
5x19P-5i2hA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3


(Bos taurus)
PF00510
(COX3)
6 ARG C 156
LYS C 157
LEU C 160
PHE C 164
PHE C 219
LEU C 223
CHD  C 307 (-4.0A)
None
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
None
None
0.33A 5x19P-5iy5C:
36.5
5x19P-5iy5C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 ARG A  82
LEU A  83
PHE A  50
LEU A  54
None
0.88A 5x19P-5ju6A:
undetectable
5x19P-5ju6A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8)
PF11991
(Trp_DMAT)
4 LEU A 164
PHE A 153
PHE A 154
LEU A 129
None
1.16A 5x19P-5jxmA:
undetectable
5x19P-5jxmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1


(Homo sapiens;
Homo sapiens)
PF05859
(Mis12)
PF03980
(Nnf1)
4 LEU A  78
PHE A  79
PHE B  45
LEU B  49
None
0.82A 5x19P-5lskA:
3.1
5x19P-5lskA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC


(Vibrio cholerae)
PF05943
(VipB)
4 LYS A 121
LEU A 124
PHE A 128
LEU A 139
None
1.15A 5x19P-5myuA:
undetectable
5x19P-5myuA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa)
no annotation 4 ARG A  78
LEU A  79
PHE A  46
LEU A  50
None
0.96A 5x19P-5nbsA:
undetectable
5x19P-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umq GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE


(Streptomyces
sp. CB03234)
no annotation 4 LEU A 121
PHE A 119
PHE A 111
LEU A  88
None
0.85A 5x19P-5umqA:
undetectable
5x19P-5umqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyh INTERAPTIN

(Legionella
pneumophila)
no annotation 4 ARG B  85
LYS B  86
LEU B  89
PHE B  94
None
1.20A 5x19P-5wyhB:
2.1
5x19P-5wyhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus)
no annotation 4 LEU D  30
PHE D  33
PHE D  79
LEU D  26
None
1.13A 5x19P-5x2bD:
undetectable
5x19P-5x2bD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER


(Camelina sativa)
PF01554
(MatE)
4 LEU A 348
PHE A 344
PHE A 380
LEU A 376
None
0.78A 5x19P-5xjjA:
3.2
5x19P-5xjjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE


(Plasmodium
vivax)
no annotation 4 LYS A 437
LEU A 440
PHE A 388
LEU A 392
None
0.60A 5x19P-6bpcA:
6.8
5x19P-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cer PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
ALPHA, SOMATIC FORM,
MITOCHONDRIAL


(Homo sapiens)
no annotation 4 ARG A 234
LEU A 231
PHE A   7
LEU A  27
None
1.22A 5x19P-6cerA:
undetectable
5x19P-6cerA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE


(Plasmodium
vivax)
no annotation 4 LYS E 437
LEU E 440
PHE E 388
LEU E 392
None
0.72A 5x19P-6d04E:
5.2
5x19P-6d04E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER


(Enterococcus
casseliflavus)
no annotation 4 LEU A 169
PHE A 361
PHE A 177
LEU A 182
None
1.18A 5x19P-6d0nA:
undetectable
5x19P-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2


(Eremothecium
gossypii)
no annotation 4 ARG B  36
LEU B  38
PHE B  39
PHE B 158
None
0.97A 5x19P-6dexB:
undetectable
5x19P-6dexB:
undetectable