SIMILAR PATTERNS OF AMINO ACIDS FOR 5X19_P_CHDP305
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1buc | BUTYRYL-COADEHYDROGENASE (Megasphaeraelsdenii) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | ARG A 31LEU A 41PHE A 19LEU A 24 | None | 0.96A | 5x19P-1bucA:3.5 | 5x19P-1bucA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e2t | N-HYDROXYARYLAMINEO-ACETYLTRANSFERASE (Salmonellaenterica) |
PF00797(Acetyltransf_2) | 4 | ARG A 88LEU A 90PHE A 174LEU A 176 | None | 1.02A | 5x19P-1e2tA:undetectable | 5x19P-1e2tA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fqt | RIESKE-TYPEFERREDOXIN OFBIPHENYL DIOXYGENASE (Paraburkholderiaxenovorans) |
PF00355(Rieske) | 4 | LYS A 87LEU A 86PHE A 70LEU A 50 | None | 0.97A | 5x19P-1fqtA:undetectable | 5x19P-1fqtA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jkw | CYCLIN H (Homo sapiens) |
PF00134(Cyclin_N)PF16899(Cyclin_C_2) | 4 | ARG A 102LEU A 106PHE A 110LEU A 129 | None | 0.85A | 5x19P-1jkwA:0.7 | 5x19P-1jkwA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lam | LEUCINEAMINOPEPTIDASE (Bos taurus) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 4 | LEU A 57PHE A 61PHE A 27LEU A 35 | None | 1.07A | 5x19P-1lamA:0.0 | 5x19P-1lamA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mdf | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | LEU A 31PHE A 27PHE A 93LEU A 56 | None | 1.06A | 5x19P-1mdfA:undetectable | 5x19P-1mdfA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpy | CATECHOL2,3-DIOXYGENASE (Pseudomonasputida) |
PF00903(Glyoxalase) | 4 | LEU A 119PHE A 117PHE A 109LEU A 85 | None | 1.18A | 5x19P-1mpyA:undetectable | 5x19P-1mpyA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1onf | GLUTATHIONEREDUCTASE (Plasmodiumfalciparum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | LYS A 173LEU A 76PHE A 74LEU A 197 | None | 1.03A | 5x19P-1onfA:undetectable | 5x19P-1onfA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qd1 | FORMIMINOTRANSFERASE-CYCLODEAMINASE (Sus scrofa) |
PF02971(FTCD)PF07837(FTCD_N) | 4 | LEU A 246PHE A 250PHE A 185LEU A 269 | None | 0.94A | 5x19P-1qd1A:undetectable | 5x19P-1qd1A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qql | FIBROBLAST GROWTHFACTOR 7/1 CHIMERA (Homo sapiens;Rattusnorvegicus) |
PF00167(FGF) | 4 | LYS A 112LEU A 111PHE A 132LEU A 23 | None | 1.12A | 5x19P-1qqlA:undetectable | 5x19P-1qqlA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suj | CONE ARRESTIN (Ambystomatigrinum) |
PF00339(Arrestin_N)PF02752(Arrestin_C) | 4 | LYS A 144LEU A 163PHE A 369LEU A 21 | None | 1.22A | 5x19P-1sujA:undetectable | 5x19P-1sujA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua2 | CELL DIVISIONPROTEIN KINASE 7 (Homo sapiens) |
PF00069(Pkinase) | 4 | LYS A 152LEU A 153PHE A 156LEU A 125 | None | 1.09A | 5x19P-1ua2A:1.8 | 5x19P-1ua2A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhf | PERIPLASMIC DIVALENTCATION TOLERANCEPROTEIN (Thermotogamaritima) |
PF03091(CutA1) | 4 | LEU A 21PHE A 30PHE A 55LEU A 69 | None | 1.09A | 5x19P-1vhfA:undetectable | 5x19P-1vhfA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8s | FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS I (Thermoproteustenax) |
PF01791(DeoC) | 4 | LYS A 215LEU A 214PHE A 243LEU A 247 | None | 1.05A | 5x19P-1w8sA:undetectable | 5x19P-1w8sA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yln | HYPOTHETICAL PROTEINVCA0042 (Vibrio cholerae) |
PF07238(PilZ)PF12945(YcgR_2) | 4 | LYS A 205LEU A 220PHE A 170LEU A 187 | None | 1.16A | 5x19P-1ylnA:undetectable | 5x19P-1ylnA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7m | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Lactococcuslactis) |
PF13393(tRNA-synt_His) | 4 | LEU A 236PHE A 240PHE A 168LEU A 172 | None | 0.69A | 5x19P-1z7mA:undetectable | 5x19P-1z7mA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zvf | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Saccharomycescerevisiae) |
PF06052(3-HAO) | 4 | LYS A 67LEU A 66PHE A 57LEU A 91 | None | 1.16A | 5x19P-1zvfA:undetectable | 5x19P-1zvfA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atp | T-CELL SURFACEGLYCOPROTEIN CD8ALPHA CHAIN (Mus musculus) |
PF07686(V-set) | 4 | LYS A 68LEU A 69PHE A 75LEU A 74 | None | 1.17A | 5x19P-2atpA:undetectable | 5x19P-2atpA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cnd | NADH-DEPENDENTNITRATE REDUCTASE (Zea mays) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | LEU A 34PHE A 32PHE A 76LEU A 41 | None | 1.21A | 5x19P-2cndA:undetectable | 5x19P-2cndA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2edz | PDZDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
PF00595(PDZ) | 4 | LYS A 18LEU A 19PHE A 29LEU A 56 | None | 1.13A | 5x19P-2edzA:undetectable | 5x19P-2edzA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk1 | BETA-HEXOSAMINIDASESUBUNIT ALPHA (Homo sapiens) |
no annotation | 4 | LEU I 319PHE I 257PHE I 305LEU I 359 | None | 1.18A | 5x19P-2gk1I:undetectable | 5x19P-2gk1I:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibd | POSSIBLETRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF00440(TetR_N) | 4 | LEU A 131PHE A 135PHE A 74LEU A 70 | None | 0.88A | 5x19P-2ibdA:undetectable | 5x19P-2ibdA:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mfq | FIBROBLAST GROWTHFACTOR RECEPTORSUBSTRATE 2 (Homo sapiens) |
PF02174(IRS) | 4 | LYS A 20PHE A 89PHE A 72LEU A 101 | None | 1.16A | 5x19P-2mfqA:undetectable | 5x19P-2mfqA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nmp | CYSTATHIONINEGAMMA-LYASE (Homo sapiens) |
PF01053(Cys_Met_Meta_PP) | 4 | LEU A 78PHE A 15PHE A 18LEU A 262 | None | 1.03A | 5x19P-2nmpA:undetectable | 5x19P-2nmpA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2opt | ACTII PROTEIN (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 4 | ARG A 75LEU A 79PHE A 83LEU A 49 | None | 0.62A | 5x19P-2optA:3.0 | 5x19P-2optA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otn | DIAMINOPIMELATEEPIMERASE (Bacillusanthracis) |
PF01678(DAP_epimerase) | 4 | ARG A 81LYS A 271LEU A 258LEU A 12 | None | 0.69A | 5x19P-2otnA:undetectable | 5x19P-2otnA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qhp | FRUCTOKINASE (Bacteroidesthetaiotaomicron) |
PF00294(PfkB) | 4 | LYS A 175LEU A 174PHE A 168LEU A 202 | NoneNoneEDO A 298 ( 4.9A)EDO A 298 (-4.9A) | 1.02A | 5x19P-2qhpA:undetectable | 5x19P-2qhpA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qp2 | UNKNOWN PROTEIN (Photorhabduslaumondii) |
PF01823(MACPF) | 5 | LYS A 335LEU A 338PHE A 342PHE A 195LEU A 194 | None | 1.26A | 5x19P-2qp2A:undetectable | 5x19P-2qp2A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wrd | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LYS A 106LEU A 109PHE A 115LEU A 176 | None | 0.90A | 5x19P-2wrdA:undetectable | 5x19P-2wrdA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x40 | BETA-GLUCOSIDASE (Thermotoganeapolitana) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | LYS A 440LEU A 441PHE A 356LEU A 396 | None | 1.22A | 5x19P-2x40A:undetectable | 5x19P-2x40A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 4 | ARG A 532LEU A 536PHE A 543LEU A 501 | None | 1.01A | 5x19P-2xgoA:undetectable | 5x19P-2xgoA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Prochlorococcusmarinus) |
PF00148(Oxidored_nitro) | 4 | LEU C 35PHE C 60PHE C 33LEU C 87 | None | 1.02A | 5x19P-2ynmC:undetectable | 5x19P-2ynmC:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aam | ENDONUCLEASE IV (Thermusthermophilus) |
PF01261(AP_endonuc_2) | 4 | LEU A 247PHE A 245PHE A 263LEU A 222 | None | 1.12A | 5x19P-3aamA:undetectable | 5x19P-3aamA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeu | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Rhodobactercapsulatus) |
PF00148(Oxidored_nitro) | 4 | LEU A 44PHE A 69PHE A 42LEU A 96 | None | 1.01A | 5x19P-3aeuA:undetectable | 5x19P-3aeuA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctt | MALTASE-GLUCOAMYLASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 4 | ARG A 144LEU A 151PHE A 152LEU A 266 | None | 1.05A | 5x19P-3cttA:undetectable | 5x19P-3cttA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3deg | GTP-BINDING PROTEINLEPA (Escherichiacoli) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF06421(LepA_C) | 4 | LEU C 299PHE C 338PHE C 310LEU C 355 | None | 1.09A | 5x19P-3degC:undetectable | 5x19P-3degC:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dl0 | ADENYLATE KINASE (Bacillussubtilis) |
PF00406(ADK)PF05191(ADK_lid) | 4 | LYS A 69LEU A 72PHE A 81LEU A 83 | None | 1.12A | 5x19P-3dl0A:undetectable | 5x19P-3dl0A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4e | CYTOCHROME P450 2E1 (Homo sapiens) |
PF00067(p450) | 4 | LYS A 461LEU A 460PHE A 458LEU A 312 | None | 1.12A | 5x19P-3e4eA:1.3 | 5x19P-3e4eA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eaf | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Aeropyrumpernix) |
PF13458(Peripla_BP_6) | 4 | LYS A 362LEU A 365PHE A 370LEU A 340 | None | 1.23A | 5x19P-3eafA:undetectable | 5x19P-3eafA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1z | PUTATIVE LYSYL-TRNASYNTHETASE (Salmonellaenterica) |
PF00152(tRNA-synt_2) | 4 | ARG A 188LEU A 192PHE A 196PHE A 153 | None | 0.87A | 5x19P-3g1zA:undetectable | 5x19P-3g1zA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrt | METALLOREGULATORSCAR (Streptococcusgordonii) |
PF01325(Fe_dep_repress)PF02742(Fe_dep_repr_C)PF04023(FeoA) | 4 | ARG A 74LYS A 75LEU A 78PHE A 82 | None | 0.66A | 5x19P-3hrtA:undetectable | 5x19P-3hrtA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1l | FANCL (Drosophilamelanogaster) |
no annotation | 4 | LYS B 233LEU B 232PHE B 285LEU B 281 | None | 1.05A | 5x19P-3k1lB:undetectable | 5x19P-3k1lB:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1t | GLUTAMATE--CYSTEINELIGASE GSHA (Methylobacillusflagellatus) |
PF08886(GshA) | 4 | ARG A 400LEU A 14PHE A 54LEU A 6 | None | 1.21A | 5x19P-3k1tA:undetectable | 5x19P-3k1tA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 4 | LYS A 359LEU A 360PHE A 11LEU A 184 | None | 1.13A | 5x19P-3lduA:undetectable | 5x19P-3lduA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llb | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF03471(CorC_HlyC) | 4 | LEU A 58PHE A 61PHE A 30LEU A 41 | None | 1.23A | 5x19P-3llbA:undetectable | 5x19P-3llbA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 4 | ARG A 172LEU A 179PHE A 180LEU A 294 | None | 1.11A | 5x19P-3lppA:undetectable | 5x19P-3lppA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 4 | LYS A 4LEU A 7PHE A 18LEU A 22 | None | 1.05A | 5x19P-3m6xA:undetectable | 5x19P-3m6xA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nre | ALDOSE 1-EPIMERASE (Escherichiacoli) |
PF01263(Aldose_epim) | 4 | LEU A 153PHE A 151PHE A 250LEU A 194 | None | 1.19A | 5x19P-3nreA:undetectable | 5x19P-3nreA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qm2 | PHOSPHOSERINEAMINOTRANSFERASE (Salmonellaenterica) |
PF00266(Aminotran_5) | 4 | LEU A 350PHE A 5PHE A 7LEU A 325 | None | 1.19A | 5x19P-3qm2A:undetectable | 5x19P-3qm2A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd5 | MYPAA.01249.C (Mycobacteriumavium) |
PF00106(adh_short) | 4 | ARG A 131LEU A 191PHE A 246LEU A 241 | None | 0.96A | 5x19P-3rd5A:undetectable | 5x19P-3rd5A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tj0 | NUCLEOPROTEIN (Influenza Bvirus) |
PF00506(Flu_NP) | 4 | ARG A 411LEU A 384PHE A 385PHE A 419 | None | 1.18A | 5x19P-3tj0A:3.4 | 5x19P-3tj0A:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vse | PUTATIVEUNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF10672(Methyltrans_SAM) | 4 | ARG A 55LEU A 60PHE A 38LEU A 32 | None | 1.15A | 5x19P-3vseA:undetectable | 5x19P-3vseA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4y | PROTEIN MXIG (Shigellaflexneri) |
PF09480(PrgH) | 4 | LYS A 106LEU A 105PHE A 103PHE A 79 | None | 0.65A | 5x19P-4a4yA:undetectable | 5x19P-4a4yA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4acj | WU:FB25H12 PROTEIN, (Danio rerio) |
PF07534(TLD) | 4 | LYS A 652LEU A 654PHE A 800LEU A 691 | None | 1.22A | 5x19P-4acjA:undetectable | 5x19P-4acjA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cn8 | PROXIMAL THREADMATRIX PROTEIN 1 (Mytilusgalloprovincialis) |
PF00092(VWA) | 4 | LYS A 234LEU A 233PHE A 79LEU A 83 | None | 0.91A | 5x19P-4cn8A:undetectable | 5x19P-4cn8A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4drs | PYRUVATE KINASE (Cryptosporidiumparvum) |
PF00224(PK)PF02887(PK_C) | 4 | ARG A 93LEU A 89PHE A 224LEU A 230 | ACT A 607 (-4.1A)ACT A 607 ( 4.9A)NoneNone | 1.12A | 5x19P-4drsA:undetectable | 5x19P-4drsA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e5t | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME, C-TERMINALDOMAIN PROTEIN (Labrenziaalexandrii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 321PHE A 23PHE A 25LEU A 376 | None | 1.03A | 5x19P-4e5tA:undetectable | 5x19P-4e5tA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flx | DNA POLYMERASE 1 (Pyrococcusabyssi) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | ARG A 266LEU A 352PHE A 356LEU A 333 | ARG A 266 ( 0.6A)LEU A 352 ( 0.6A)PHE A 356 ( 1.3A)LEU A 333 ( 0.6A) | 0.90A | 5x19P-4flxA:2.7 | 5x19P-4flxA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjl | NAPHTHALENE1,2-DIOXYGENASESUBUNIT ALPHA (Pseudomonas sp.C18) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 4 | LYS A 136LEU A 135PHE A 108LEU A 88 | None | 1.22A | 5x19P-4hjlA:undetectable | 5x19P-4hjlA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hqf | THROMBOSPONDIN-RELATED ANONYMOUSPROTEIN, TRAP (Plasmodiumfalciparum) |
PF00092(VWA) | 5 | ARG A 176LYS A 173LEU A 172PHE A 198LEU A 202 | None | 1.09A | 5x19P-4hqfA:undetectable | 5x19P-4hqfA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1s | MELANOMADIFFERENTIATIONASSOCIATED PROTEIN-5 (Sus scrofa) |
PF00271(Helicase_C) | 4 | LYS A 681LEU A 684PHE A 549LEU A 553 | None | 0.67A | 5x19P-4i1sA:2.3 | 5x19P-4i1sA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lim | DNA PRIMASE SMALLSUBUNIT (Saccharomycescerevisiae) |
PF01896(DNA_primase_S) | 4 | ARG A 58LYS A 57PHE A 80LEU A 324 | None | 1.14A | 5x19P-4limA:undetectable | 5x19P-4limA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6q | VOSA (Aspergillusnidulans) |
PF11754(Velvet) | 4 | LYS A 132LEU A 131PHE A 129LEU A 121 | None | 0.85A | 5x19P-4n6qA:undetectable | 5x19P-4n6qA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 4 | LEU A 636PHE A 621PHE A 623LEU A 921 | NoneNoneNoneSEP A 922 ( 4.5A) | 1.17A | 5x19P-4otdA:undetectable | 5x19P-4otdA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q62 | LEUCINE-RICHREPEAT-AND COILEDCOIL-CONTAININGPROTEIN (Legionellapneumophila) |
PF13855(LRR_8) | 5 | LYS A 159LEU A 161PHE A 179PHE A 164LEU A 136 | None | 1.46A | 5x19P-4q62A:undetectable | 5x19P-4q62A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmi | CYTOSKELETON-ASSOCIATED PROTEIN 5 (Homo sapiens) |
PF12348(CLASP_N) | 4 | LYS A1005LEU A1006PHE A1045LEU A1016 | None | 1.19A | 5x19P-4qmiA:undetectable | 5x19P-4qmiA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgp | CSM6_III-A (Streptococcusmutans) |
PF09659(Cas_Csm6) | 4 | LEU A 221PHE A 220PHE A 98LEU A 86 | None | 0.94A | 5x19P-4rgpA:2.4 | 5x19P-4rgpA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnc | ESTERASE (Rhodococcus sp.ECU1013) |
PF12697(Abhydrolase_6) | 4 | ARG A 196LEU A 163PHE A 185LEU A 189 | None | 0.85A | 5x19P-4rncA:undetectable | 5x19P-4rncA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4roa | SERPIN 2 (Anophelesgambiae) |
PF00079(Serpin) | 4 | ARG A 384LEU A 262PHE A 260PHE A 380 | None | 1.04A | 5x19P-4roaA:undetectable | 5x19P-4roaA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5j | ADENYLATE KINASE (Streptococcuspneumoniae) |
PF00406(ADK) | 4 | LYS A 69LEU A 72PHE A 82LEU A 84 | None | 1.03A | 5x19P-4w5jA:undetectable | 5x19P-4w5jA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wpx | CELL DIVISIONCONTROL PROTEIN31-LIKE PROTEIN (Chaetomiumthermophilum) |
PF00036(EF-hand_1)PF13499(EF-hand_7) | 4 | ARG A 27PHE A 50PHE A 35LEU A 34 | None | 1.09A | 5x19P-4wpxA:undetectable | 5x19P-4wpxA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzs | SIMILARITY TOHELICASE MOT1 (Encephalitozooncuniculi) |
no annotation | 4 | LYS C 281LEU C 282PHE C 304LEU C 300 | None | 1.11A | 5x19P-4wzsC:undetectable | 5x19P-4wzsC:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x3m | RNA 2'-O RIBOSEMETHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase) | 4 | ARG A 221LEU A 183PHE A 205LEU A 176 | None | 1.19A | 5x19P-4x3mA:undetectable | 5x19P-4x3mA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xt8 | RV2671 (Mycobacteriumtuberculosis) |
PF01872(RibD_C) | 4 | ARG A 155LEU A 156PHE A 133LEU A 126 | None | 1.22A | 5x19P-4xt8A:undetectable | 5x19P-4xt8A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7v | PUTATIVE GLYCOSIDASEPH117-RELATED (Bacteroidesthetaiotaomicron) |
PF04041(Glyco_hydro_130) | 4 | LYS B 253LEU B 254PHE B 317PHE B 309 | None | 0.86A | 5x19P-5a7vB:undetectable | 5x19P-5a7vB:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ajh | CUTINASE (Fusariumoxysporum) |
PF01083(Cutinase) | 4 | LYS A 59LEU A 60PHE A 37LEU A 204 | None | 1.19A | 5x19P-5ajhA:undetectable | 5x19P-5ajhA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ckm | MANNAN-BINDINGLECTIN SERINEPEPTIDASE 2 (Rattusnorvegicus) |
PF00431(CUB)PF07645(EGF_CA) | 4 | ARG A 80LEU A 70PHE A 111PHE A 42 | None | 1.00A | 5x19P-5ckmA:undetectable | 5x19P-5ckmA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cww | NUCLEOPORIN NUP82NUCLEOPORIN NUP159 (Chaetomiumthermophilum;Chaetomiumthermophilum) |
no annotationno annotation | 4 | ARG C1447LYS C1448LEU C1451LEU B 425 | None | 0.94A | 5x19P-5cwwC:undetectable | 5x19P-5cwwC:8.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d2e | MLNE (Bacillusvelezensis) |
PF08659(KR) | 4 | LYS A 208PHE A 205PHE A 159LEU A 155 | None | 1.20A | 5x19P-5d2eA:undetectable | 5x19P-5d2eA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7w | SERRALYSIN (Serratiamarcescens) |
PF00353(HemolysinCabind)PF00413(Peptidase_M10)PF08548(Peptidase_M10_C) | 4 | LYS A 57LEU A 58PHE A 60LEU A 182 | LYS A 57 ( 0.0A)LEU A 58 ( 0.6A)PHE A 60 ( 1.3A)LEU A 182 ( 0.6A) | 0.91A | 5x19P-5d7wA:undetectable | 5x19P-5d7wA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyt | ADENYLOSUCCINATELYASE (Schistosomamansoni) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | LEU A 47PHE A 49PHE A 207LEU A 217 | None | 0.98A | 5x19P-5eytA:3.9 | 5x19P-5eytA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g3y | ADENYLATE KINSE (syntheticconstruct) |
PF00406(ADK)PF05191(ADK_lid) | 4 | LYS A 69LEU A 72PHE A 81LEU A 83 | None | 0.84A | 5x19P-5g3yA:undetectable | 5x19P-5g3yA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gk9 | HISTONEACETYLTRANSFERASEKAT7 (Homo sapiens) |
PF01853(MOZ_SAS) | 4 | LYS A 602LEU A 601PHE A 493LEU A 497 | None | 1.13A | 5x19P-5gk9A:undetectable | 5x19P-5gk9A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgr | ORANGE CAROTENOIDPROTEIN (OCP) (Nostoc sp. PCC7120) |
PF02136(NTF2)PF09150(Carot_N) | 4 | LYS A 69LEU A 68PHE A 109LEU A 113 | NoneNoneNone45D A 501 ( 4.8A) | 1.07A | 5x19P-5hgrA:undetectable | 5x19P-5hgrA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2h | O-METHYLTRANSFERASEFAMILY 2 (Planctopiruslimnophila) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 4 | ARG A 293LEU A 295PHE A 173LEU A 177 | None | 1.02A | 5x19P-5i2hA:undetectable | 5x19P-5i2hA:22.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5iy5 | CYTOCHROME C OXIDASESUBUNIT 3 (Bos taurus) |
PF00510(COX3) | 6 | ARG C 156LYS C 157LEU C 160PHE C 164PHE C 219LEU C 223 | CHD C 307 (-4.0A)NoneCHD C 307 ( 3.9A)CHD C 307 (-3.9A)NoneNone | 0.33A | 5x19P-5iy5C:36.5 | 5x19P-5iy5C:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ju6 | BETA-GLUCOSIDASE (Rasamsoniaemersonii) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ARG A 82LEU A 83PHE A 50LEU A 54 | None | 0.88A | 5x19P-5ju6A:undetectable | 5x19P-5ju6A:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxm | PRIB (Streptomycessp. RM-5-8) |
PF11991(Trp_DMAT) | 4 | LEU A 164PHE A 153PHE A 154LEU A 129 | None | 1.16A | 5x19P-5jxmA:undetectable | 5x19P-5jxmA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsk | PROTEIN MIS12HOMOLOGPOLYAMINE-MODULATEDFACTOR 1 (Homo sapiens;Homo sapiens) |
PF05859(Mis12)PF03980(Nnf1) | 4 | LEU A 78PHE A 79PHE B 45LEU B 49 | None | 0.82A | 5x19P-5lskA:3.1 | 5x19P-5lskA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5myu | TYPE VI SECRETIONSYSTEM PROTEIN IMPC (Vibrio cholerae) |
PF05943(VipB) | 4 | LYS A 121LEU A 124PHE A 128LEU A 139 | None | 1.15A | 5x19P-5myuA:undetectable | 5x19P-5myuA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nbs | BETA-GLUCOSIDASE (Neurosporacrassa) |
no annotation | 4 | ARG A 78LEU A 79PHE A 46LEU A 50 | None | 0.96A | 5x19P-5nbsA:undetectable | 5x19P-5nbsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5umq | GLYOXALASE/BLEOMYCINRESISANCEPROTEIN/DIOXYGENASE (Streptomycessp. CB03234) |
no annotation | 4 | LEU A 121PHE A 119PHE A 111LEU A 88 | None | 0.85A | 5x19P-5umqA:undetectable | 5x19P-5umqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyh | INTERAPTIN (Legionellapneumophila) |
no annotation | 4 | ARG B 85LYS B 86LEU B 89PHE B 94 | None | 1.20A | 5x19P-5wyhB:2.1 | 5x19P-5wyhB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2b | SULFOTRANSFERASE (Mus musculus) |
no annotation | 4 | LEU D 30PHE D 33PHE D 79LEU D 26 | None | 1.13A | 5x19P-5x2bD:undetectable | 5x19P-5x2bD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjj | MULTI DRUG EFFLUXTRANSPORTER (Camelina sativa) |
PF01554(MatE) | 4 | LEU A 348PHE A 344PHE A 380LEU A 376 | None | 0.78A | 5x19P-5xjjA:3.2 | 5x19P-5xjjA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bpc | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 4 | LYS A 437LEU A 440PHE A 388LEU A 392 | None | 0.60A | 5x19P-6bpcA:6.8 | 5x19P-6bpcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cer | PYRUVATEDEHYDROGENASE E1COMPONENT SUBUNITALPHA, SOMATIC FORM,MITOCHONDRIAL (Homo sapiens) |
no annotation | 4 | ARG A 234LEU A 231PHE A 7LEU A 27 | None | 1.22A | 5x19P-6cerA:undetectable | 5x19P-6cerA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d04 | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 4 | LYS E 437LEU E 440PHE E 388LEU E 392 | None | 0.72A | 5x19P-6d04E:5.2 | 5x19P-6d04E:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) |
no annotation | 4 | LEU A 169PHE A 361PHE A 177LEU A 182 | None | 1.18A | 5x19P-6d0nA:undetectable | 5x19P-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dex | SUPPRESSOR OFHYDROXYUREASENSITIVITY PROTEIN2 (Eremotheciumgossypii) |
no annotation | 4 | ARG B 36LEU B 38PHE B 39PHE B 158 | None | 0.97A | 5x19P-6dexB:undetectable | 5x19P-6dexB:undetectable |