SIMILAR PATTERNS OF AMINO ACIDS FOR 5X19_C_CHDC304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.90A 5x19C-1914A:
0.8
5x19J-1914A:
0.0		 5x19C-1914A:
19.40
5x19J-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 LEU A 313
PHE A 205
LEU A 104
PHE A 100
 None
 0.94A 5x19C-1agxA:
undetectable
5x19J-1agxA:
0.0		 5x19C-1agxA:
21.25
5x19J-1agxA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.98A 5x19C-1bucA:
1.8
5x19J-1bucA:
0.0		 5x19C-1bucA:
17.69
5x19J-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.62A 5x19C-1dj3A:
undetectable
5x19J-1dj3A:
0.0		 5x19C-1dj3A:
19.00
5x19J-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 200
PHE A 183
LEU A 179
PHE A 175
 None
 0.73A 5x19C-1dj3A:
undetectable
5x19J-1dj3A:
0.0		 5x19C-1dj3A:
19.00
5x19J-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		4 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.00A 5x19C-1e2tA:
undetectable
5x19J-1e2tA:
0.0		 5x19C-1e2tA:
23.15
5x19J-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3p PHOSPHOGLUCOSE
ISOMERASE

(Thermococcus
litoralis) 		PF06560
(GPI) 		4 LEU A  11
PHE A  13
LEU A 103
PHE A 101
 None
 1.04A 5x19C-1j3pA:
undetectable
5x19J-1j3pA:
undetectable		 5x19C-1j3pA:
21.27
5x19J-1j3pA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.97A 5x19C-1js6A:
undetectable
5x19J-1js6A:
0.0		 5x19C-1js6A:
19.84
5x19J-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.86A 5x19C-1kl7A:
undetectable
5x19J-1kl7A:
0.0		 5x19C-1kl7A:
21.24
5x19J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A  64
PHE A  68
LEU A 117
PHE A 116
 None
 1.03A 5x19C-1m0uA:
3.6
5x19J-1m0uA:
0.0		 5x19C-1m0uA:
21.20
5x19J-1m0uA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.96A 5x19C-1ny5A:
undetectable
5x19J-1ny5A:
undetectable		 5x19C-1ny5A:
19.75
5x19J-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 592
LEU B 596
PHE B 598
 None
 0.95A 5x19C-1ovlB:
undetectable
5x19J-1ovlB:
undetectable		 5x19C-1ovlB:
19.94
5x19J-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p32 MITOCHONDRIAL MATRIX
PROTEIN, SF2P32

(Homo sapiens) 		PF02330
(MAM33) 		4 LEU A  86
PHE A  82
LEU A 275
PHE A 271
 None
 1.04A 5x19C-1p32A:
undetectable
5x19J-1p32A:
undetectable		 5x19C-1p32A:
20.22
5x19J-1p32A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5q FK506-BINDING
PROTEIN 4

(Homo sapiens) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF07719
(TPR_2) 		4 ARG A 186
LEU A 188
PHE A 190
LEU A 200
 None
 1.04A 5x19C-1p5qA:
4.1
5x19J-1p5qA:
2.4		 5x19C-1p5qA:
20.24
5x19J-1p5qA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.91A 5x19C-1pjaA:
undetectable
5x19J-1pjaA:
undetectable		 5x19C-1pjaA:
22.12
5x19J-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmj BETA-1,4-MANNANASE

(Caldicellulosiruptor
saccharolyticus) 		PF09212
(CBM27) 		4 LEU X  50
PHE X 162
LEU X  65
PHE X  19
 None
 1.04A 5x19C-1pmjX:
undetectable
5x19J-1pmjX:
undetectable		 5x19C-1pmjX:
19.08
5x19J-1pmjX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 LEU A 537
PHE A 529
LEU A 525
PHE A 521
 None
 1.00A 5x19C-1qf6A:
undetectable
5x19J-1qf6A:
undetectable		 5x19C-1qf6A:
17.24
5x19J-1qf6A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.85A 5x19C-1u8vA:
3.7
5x19J-1u8vA:
undetectable		 5x19C-1u8vA:
19.70
5x19J-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.84A 5x19C-1vkuA:
undetectable
5x19J-1vkuA:
undetectable		 5x19C-1vkuA:
13.64
5x19J-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A   5
PHE A 235
LEU A 231
PHE A 227
 None
 0.87A 5x19C-1xw8A:
undetectable
5x19J-1xw8A:
undetectable		 5x19C-1xw8A:
18.97
5x19J-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A 188
PHE A 227
LEU A 231
PHE A 235
 None
 1.04A 5x19C-1xw8A:
undetectable
5x19J-1xw8A:
undetectable		 5x19C-1xw8A:
18.97
5x19J-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw0 TRYPTOPHAN
2,3-DIOXYGENASE

(Xanthomonas
campestris) 		PF03301
(Trp_dioxygenase) 		4 LEU A 129
PHE A 149
LEU A 159
PHE A 136
 None
 0.99A 5x19C-1yw0A:
4.6
5x19J-1yw0A:
undetectable		 5x19C-1yw0A:
22.04
5x19J-1yw0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		4 LEU A  65
PHE A  61
LEU A  88
PHE A  87
 None
 1.05A 5x19C-1z72A:
3.8
5x19J-1z72A:
undetectable		 5x19C-1z72A:
21.56
5x19J-1z72A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 1.04A 5x19C-1za4A:
undetectable
5x19J-1za4A:
undetectable		 5x19C-1za4A:
20.43
5x19J-1za4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2a TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF11474
(N-Term_TEN) 		4 LEU A  36
PHE A  59
LEU A 139
PHE A 148
 None
 1.00A 5x19C-2b2aA:
undetectable
5x19J-2b2aA:
undetectable		 5x19C-2b2aA:
21.99
5x19J-2b2aA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU X  53
PHE X 368
LEU X 364
PHE X 353
 None
 1.05A 5x19C-2b5dX:
3.8
5x19J-2b5dX:
undetectable		 5x19C-2b5dX:
18.95
5x19J-2b5dX:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		4 LEU A 232
PHE A 197
LEU A 193
PHE A 225
 None
 0.99A 5x19C-2epjA:
undetectable
5x19J-2epjA:
undetectable		 5x19C-2epjA:
19.55
5x19J-2epjA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.82A 5x19C-2hajA:
undetectable
5x19J-2hajA:
undetectable		 5x19C-2hajA:
19.01
5x19J-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkl ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF15445
(ATS) 		4 LEU A  54
PHE A  21
LEU A  17
PHE A   9
 None
 0.90A 5x19C-2lklA:
undetectable
5x19J-2lklA:
undetectable		 5x19C-2lklA:
13.41
5x19J-2lklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.88A 5x19C-2nt8A:
2.7
5x19J-2nt8A:
undetectable		 5x19C-2nt8A:
21.30
5x19J-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oum 50S RIBOSOMAL
PROTEIN L1

(Thermus
thermophilus) 		PF00687
(Ribosomal_L1) 		4 LEU A  47
PHE A 208
LEU A 196
PHE A 163
 None
 1.05A 5x19C-2oumA:
undetectable
5x19J-2oumA:
undetectable		 5x19C-2oumA:
16.73
5x19J-2oumA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe4 HYALURONIDASE-1

(Homo sapiens) 		PF01630
(Glyco_hydro_56) 		4 ARG A 194
LEU A 193
PHE A 110
LEU A 114
 None
 1.03A 5x19C-2pe4A:
undetectable
5x19J-2pe4A:
undetectable		 5x19C-2pe4A:
21.24
5x19J-2pe4A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		4 LEU A  37
PHE A  96
LEU A  91
PHE A  87
 None
 1.02A 5x19C-2qvpA:
undetectable
5x19J-2qvpA:
undetectable		 5x19C-2qvpA:
21.97
5x19J-2qvpA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens) 		PF05712
(MRG) 		4 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.88A 5x19C-2y0nA:
undetectable
5x19J-2y0nA:
undetectable		 5x19C-2y0nA:
18.22
5x19J-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.90A 5x19C-3cfxA:
undetectable
5x19J-3cfxA:
undetectable		 5x19C-3cfxA:
20.43
5x19J-3cfxA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqh L-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE ULAE

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 LEU A 175
PHE A 180
LEU A 138
PHE A 134
 None
 1.00A 5x19C-3cqhA:
undetectable
5x19J-3cqhA:
undetectable		 5x19C-3cqhA:
21.36
5x19J-3cqhA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04051
(TRAPP)
PF04051
(TRAPP) 		4 LEU D  29
PHE B 192
LEU B 218
PHE B  66
 None
 1.03A 5x19C-3cueD:
undetectable
5x19J-3cueD:
undetectable		 5x19C-3cueD:
19.35
5x19J-3cueD:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.88A 5x19C-3gajA:
2.7
5x19J-3gajA:
undetectable		 5x19C-3gajA:
21.16
5x19J-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 227
PHE A 187
LEU A 183
PHE A 179
 None
 1.00A 5x19C-3iayA:
2.1
5x19J-3iayA:
undetectable		 5x19C-3iayA:
13.74
5x19J-3iayA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 5x19C-3iv0A:
undetectable
5x19J-3iv0A:
undetectable		 5x19C-3iv0A:
20.57
5x19J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 530
PHE A 569
LEU A 566
PHE A 526
 None
 0.92A 5x19C-3j9dA:
undetectable
5x19J-3j9dA:
undetectable		 5x19C-3j9dA:
13.31
5x19J-3j9dA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.97A 5x19C-3k40A:
undetectable
5x19J-3k40A:
undetectable		 5x19C-3k40A:
19.79
5x19J-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.87A 5x19C-3k6xA:
undetectable
5x19J-3k6xA:
undetectable		 5x19C-3k6xA:
20.87
5x19J-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.89A 5x19C-3lcrA:
undetectable
5x19J-3lcrA:
undetectable		 5x19C-3lcrA:
20.45
5x19J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		4 ARG A 197
LEU A 193
LEU A 211
PHE A 203
 None
 1.04A 5x19C-3lmmA:
undetectable
5x19J-3lmmA:
undetectable		 5x19C-3lmmA:
17.18
5x19J-3lmmA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 1.02A 5x19C-3n3zA:
undetectable
5x19J-3n3zA:
undetectable		 5x19C-3n3zA:
21.17
5x19J-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.96A 5x19C-3pjaA:
3.8
5x19J-3pjaA:
undetectable		 5x19C-3pjaA:
20.88
5x19J-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 LEU A 198
PHE A 181
LEU A 177
PHE A 173
 None
 1.01A 5x19C-3pjaA:
3.8
5x19J-3pjaA:
undetectable		 5x19C-3pjaA:
20.88
5x19J-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 LEU A  81
PHE A  83
LEU A  94
PHE A 148
 None
 0.81A 5x19C-3q4iA:
3.5
5x19J-3q4iA:
undetectable		 5x19C-3q4iA:
20.44
5x19J-3q4iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE

(Pyrococcus
abyssi) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.92A 5x19C-4a8eA:
undetectable
5x19J-4a8eA:
undetectable		 5x19C-4a8eA:
19.68
5x19J-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE

(Trypanosoma
cruzi) 		PF00102
(Y_phosphatase) 		4 LEU A 176
PHE A 186
LEU A 108
PHE A 104
 None
None
None
FMT  A1306 ( 4.8A)
 1.03A 5x19C-4az1A:
undetectable
5x19J-4az1A:
undetectable		 5x19C-4az1A:
19.87
5x19J-4az1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 LEU A 276
PHE A 237
LEU A 226
PHE A 222
 None
 0.91A 5x19C-4bgbA:
undetectable
5x19J-4bgbA:
undetectable		 5x19C-4bgbA:
19.53
5x19J-4bgbA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt1 TRANSCRIPTIONAL
REGULATOR

(Escherichia
virus Mu) 		PF00158
(Sigma54_activat) 		4 LEU B 194
PHE B 204
LEU B 208
PHE B 227
 None
 0.97A 5x19C-4bt1B:
undetectable
5x19J-4bt1B:
undetectable		 5x19C-4bt1B:
18.22
5x19J-4bt1B:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.73A 5x19C-4c8qH:
undetectable
5x19J-4c8qH:
undetectable		 5x19C-4c8qH:
19.40
5x19J-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 ARG A 176
LEU A 172
PHE A 198
LEU A 202
 None
 0.98A 5x19C-4hqfA:
undetectable
5x19J-4hqfA:
undetectable		 5x19C-4hqfA:
20.74
5x19J-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		no annotation 4 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 0.94A 5x19C-4kd5C:
undetectable
5x19J-4kd5C:
undetectable		 5x19C-4kd5C:
19.08
5x19J-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.94A 5x19C-4l4uA:
undetectable
5x19J-4l4uA:
undetectable		 5x19C-4l4uA:
18.32
5x19J-4l4uA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A  67
PHE A 104
LEU A  94
PHE A   4
 None
 0.91A 5x19C-4nreA:
undetectable
5x19J-4nreA:
undetectable		 5x19C-4nreA:
18.02
5x19J-4nreA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nso EFFECTOR PROTEIN

(Vibrio cholerae) 		no annotation 4 ARG A 981
LEU A 982
PHE A 943
LEU A 949
 None
 0.89A 5x19C-4nsoA:
undetectable
5x19J-4nsoA:
undetectable		 5x19C-4nsoA:
20.21
5x19J-4nsoA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213

(Methanocaldococcus
jannaschii) 		PF01435
(Peptidase_M48) 		4 LEU A  72
PHE A  84
LEU A  88
PHE A  65
 None
 0.96A 5x19C-4qhiA:
undetectable
5x19J-4qhiA:
undetectable		 5x19C-4qhiA:
16.09
5x19J-4qhiA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 LEU A  77
PHE A 157
LEU A 103
PHE A  52
 None
 1.00A 5x19C-4qjyA:
undetectable
5x19J-4qjyA:
undetectable		 5x19C-4qjyA:
16.02
5x19J-4qjyA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 LEU A 113
PHE A  52
LEU A 103
PHE A 157
 None
 1.01A 5x19C-4qjyA:
undetectable
5x19J-4qjyA:
undetectable		 5x19C-4qjyA:
16.02
5x19J-4qjyA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B  75
PHE B  83
LEU B  87
PHE B  91
 None
 0.72A 5x19C-4r0mB:
undetectable
5x19J-4r0mB:
undetectable		 5x19C-4r0mB:
17.42
5x19J-4r0mB:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 213
PHE A 345
LEU A 353
PHE A 261
 None
 1.04A 5x19C-4rjkA:
undetectable
5x19J-4rjkA:
undetectable		 5x19C-4rjkA:
18.58
5x19J-4rjkA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ARG A 196
LEU A 163
PHE A 185
LEU A 189
 None
 0.82A 5x19C-4rncA:
undetectable
5x19J-4rncA:
undetectable		 5x19C-4rncA:
21.32
5x19J-4rncA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 LEU A  31
PHE A  29
LEU A  42
PHE A  38
 None
None
None
INS  A 401 (-4.5A)
 0.98A 5x19C-4rxmA:
undetectable
5x19J-4rxmA:
undetectable		 5x19C-4rxmA:
20.81
5x19J-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 LEU A 145
PHE A 130
LEU A 125
PHE A 121
 None
 1.02A 5x19C-4ud4A:
undetectable
5x19J-4ud4A:
undetectable		 5x19C-4ud4A:
19.95
5x19J-4ud4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		4 LEU A 495
PHE A 507
LEU A  97
PHE A 488
 None
 1.02A 5x19C-4zcfA:
undetectable
5x19J-4zcfA:
undetectable		 5x19C-4zcfA:
17.05
5x19J-4zcfA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 LEU B  86
PHE B  17
LEU B  13
PHE B   9
 None
 0.88A 5x19C-5aoxB:
undetectable
5x19J-5aoxB:
undetectable		 5x19C-5aoxB:
17.86
5x19J-5aoxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 ARG A 195
LEU A 236
PHE A 162
LEU A 191
 None
 0.87A 5x19C-5bzaA:
undetectable
5x19J-5bzaA:
undetectable		 5x19C-5bzaA:
17.12
5x19J-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		4 LEU A 435
PHE A 416
LEU A 420
PHE A 428
 None
 1.00A 5x19C-5cb2A:
3.0
5x19J-5cb2A:
undetectable		 5x19C-5cb2A:
15.17
5x19J-5cb2A:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 ARG A 223
LEU A 200
PHE A 196
LEU A 193
PHE A 189
 None
 1.44A 5x19C-5cqfA:
undetectable
5x19J-5cqfA:
undetectable		 5x19C-5cqfA:
21.84
5x19J-5cqfA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 1.04A 5x19C-5ddbA:
1.9
5x19J-5ddbA:
undetectable		 5x19C-5ddbA:
17.43
5x19J-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 LEU A 246
PHE A 270
LEU A 242
PHE A 107
 None
 0.93A 5x19C-5e5uA:
undetectable
5x19J-5e5uA:
undetectable		 5x19C-5e5uA:
19.59
5x19J-5e5uA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6g DE NOVO DESIGNED
PROTEIN CA01

(synthetic
construct) 		no annotation 4 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.81A 5x19C-5e6gA:
3.6
5x19J-5e6gA:
undetectable		 5x19C-5e6gA:
19.51
5x19J-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgr CELL SURFACE PROTEIN
SPAA

(Lactobacillus
rhamnosus) 		no annotation 4 LEU A 210
PHE A 245
LEU A 255
PHE A 258
 None
 0.96A 5x19C-5fgrA:
undetectable
5x19J-5fgrA:
undetectable		 5x19C-5fgrA:
16.15
5x19J-5fgrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		4 ARG A  36
LEU A  38
PHE A  14
LEU A  13
 None
 0.97A 5x19C-5gnmA:
undetectable
5x19J-5gnmA:
undetectable		 5x19C-5gnmA:
21.04
5x19J-5gnmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdl CELL SURFACE PROTEIN
SPAA

(Lactobacillus
rhamnosus) 		no annotation 4 LEU A 210
PHE A 245
LEU A 255
PHE A 258
 None
 0.93A 5x19C-5hdlA:
undetectable
5x19J-5hdlA:
undetectable		 5x19C-5hdlA:
22.39
5x19J-5hdlA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED

(Oryza sativa) 		PF03514
(GRAS) 		4 ARG A 427
LEU A 431
PHE A 398
LEU A 393
 None
 1.03A 5x19C-5hyzA:
undetectable
5x19J-5hyzA:
undetectable		 5x19C-5hyzA:
21.39
5x19J-5hyzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ARG A 293
LEU A 295
PHE A 173
LEU A 177
 None
 1.02A 5x19C-5i2hA:
undetectable
5x19J-5i2hA:
undetectable		 5x19C-5i2hA:
22.46
5x19J-5i2hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 LEU A 109
PHE A 132
LEU A 150
PHE A  84
 None
 1.00A 5x19C-5iclA:
undetectable
5x19J-5iclA:
undetectable		 5x19C-5iclA:
20.22
5x19J-5iclA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 LEU A 109
PHE A 132
LEU A 150
PHE A  84
 None
 0.96A 5x19C-5ij6A:
undetectable
5x19J-5ij6A:
undetectable		 5x19C-5ij6A:
20.78
5x19J-5ij6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 LEU A  87
PHE A 204
LEU A 208
PHE A 212
 None
 0.77A 5x19C-5ipxA:
3.7
5x19J-5ipxA:
undetectable		 5x19C-5ipxA:
20.47
5x19J-5ipxA:
11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		4 ARG C 156
LEU C 160
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 ( 3.9A)
None
None
 0.08A 5x19C-5iy5C:
36.5
5x19J-5iy5C:
undetectable		 5x19C-5iy5C:
100.00
5x19J-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 385
PHE A 434
LEU A 432
PHE A 360
 None
 0.96A 5x19C-5jbgA:
3.1
5x19J-5jbgA:
undetectable		 5x19C-5jbgA:
15.81
5x19J-5jbgA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Myxococcus
xanthus) 		PF00378
(ECH_1) 		4 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.84A 5x19C-5jbwA:
undetectable
5x19J-5jbwA:
undetectable		 5x19C-5jbwA:
20.91
5x19J-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A  82
LEU A  83
PHE A  50
LEU A  54
 None
 0.88A 5x19C-5ju6A:
undetectable
5x19J-5ju6A:
undetectable		 5x19C-5ju6A:
13.89
5x19J-5ju6A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llq METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 1.00A 5x19C-5llqA:
undetectable
5x19J-5llqA:
undetectable		 5x19C-5llqA:
19.92
5x19J-5llqA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.80A 5x19C-5lmgA:
3.5
5x19J-5lmgA:
undetectable		 5x19C-5lmgA:
18.33
5x19J-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 4 LEU A 153
PHE A 181
LEU A 179
PHE A 201
 None
 0.78A 5x19C-5ly8A:
undetectable
5x19J-5ly8A:
undetectable		 5x19C-5ly8A:
20.48
5x19J-5ly8A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 LEU B 636
PHE B   9
LEU B  85
PHE B  81
 None
 1.00A 5x19C-5mrwB:
2.1
5x19J-5mrwB:
undetectable		 5x19C-5mrwB:
18.06
5x19J-5mrwB:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ARG A  78
LEU A  79
PHE A  46
LEU A  50
 None
 0.96A 5x19C-5nbsA:
undetectable
5x19J-5nbsA:
undetectable		 5x19C-5nbsA:
undetectable
5x19J-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 LEU A 415
PHE A 396
LEU A 392
PHE A 388
 None
 1.01A 5x19C-5oglA:
undetectable
5x19J-5oglA:
undetectable		 5x19C-5oglA:
16.25
5x19J-5oglA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		4 LEU A 641
PHE A 550
LEU A 673
PHE A 648
 None
 0.97A 5x19C-5tr1A:
2.8
5x19J-5tr1A:
undetectable		 5x19C-5tr1A:
15.99
5x19J-5tr1A:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE

(Synechococcus
sp. RS9917) 		no annotation 4 LEU A 106
PHE A 200
LEU A 204
PHE A 209
 None
 1.04A 5x19C-5ux2A:
3.4
5x19J-5ux2A:
undetectable		 5x19C-5ux2A:
undetectable
5x19J-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 LEU A 510
PHE A 909
LEU A 592
PHE A 588
 None
 1.01A 5x19C-5wlhA:
undetectable
5x19J-5wlhA:
undetectable		 5x19C-5wlhA:
9.83
5x19J-5wlhA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 4 LEU A  52
PHE A  86
LEU A  35
PHE A  21
 None
 0.97A 5x19C-5x7uA:
undetectable
5x19J-5x7uA:
undetectable		 5x19C-5x7uA:
undetectable
5x19J-5x7uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo7 HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Plasmodium
vivax) 		no annotation 4 LEU A  50
PHE A 191
LEU A 173
PHE A  82
 None
 0.99A 5x19C-6bo7A:
undetectable
5x19J-6bo7A:
undetectable		 5x19C-6bo7A:
undetectable
5x19J-6bo7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekt P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 LEU A 109
PHE A 166
LEU A 162
PHE A 158
 None
 0.96A 5x19C-6ektA:
undetectable
5x19J-6ektA:
undetectable		 5x19C-6ektA:
19.06
5x19J-6ektA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 LEU A 352
PHE A 474
LEU A 470
PHE A 466
 None
 0.71A 5x19C-6gneA:
undetectable
5x19J-6gneA:
undetectable		 5x19C-6gneA:
undetectable
5x19J-6gneA:
undetectable