SIMILAR PATTERNS OF AMINO ACIDS FOR 5WZ1_G_SAMG601_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eiz | FTSJ (Escherichiacoli) |
PF01728(FtsJ) | 5 | GLY A 59GLY A 64TRP A 65ASP A 99ASP A 124 | SAM A 301 (-3.6A)SAM A 301 (-3.1A)SAM A 301 (-3.6A)SAM A 301 (-3.5A)SAM A 301 (-3.6A) | 0.46A | 5wz1G-1eizA:14.7 | 5wz1G-1eizA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jax | CONSERVEDHYPOTHETICAL PROTEIN (Archaeoglobusfulgidus) |
PF03807(F420_oxidored) | 5 | GLY A 30GLY A 8HIS A 25VAL A 164ILE A 67 | None | 0.98A | 5wz1G-1jaxA:3.7 | 5wz1G-1jaxA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jjf | ENDO-1,4-BETA-XYLANASE Z (Ruminiclostridiumthermocellum) |
PF00756(Esterase) | 5 | GLY A 174GLY A 182GLY A 170LYS A 188ASP A 187 | None | 0.99A | 5wz1G-1jjfA:undetectable | 5wz1G-1jjfA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llu | ALCOHOLDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 336GLY A 156GLY A 180THR A 158ILE A 152 | NoneNoneNAD A1250 (-3.4A)NAD A1250 (-3.0A)None | 0.96A | 5wz1G-1lluA:4.5 | 5wz1G-1lluA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ltm | 36 KDA SOLUBLE LYTICTRANSGLYCOSYLASE (Escherichiacoli) |
PF13406(SLT_2) | 5 | GLY A 170GLY A 224GLY A 215VAL A 256ILE A 159 | None | 0.93A | 5wz1G-1ltmA:undetectable | 5wz1G-1ltmA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q50 | GLUCOSE-6-PHOSPHATEISOMERASE (Leishmaniamexicana) |
PF00342(PGI) | 5 | GLY A 206GLY A 210GLU A 545ASP A 457VAL A 390 | None | 0.95A | 5wz1G-1q50A:undetectable | 5wz1G-1q50A:19.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r6a | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A 887 (-3.0A)SAH A 887 (-3.6A)SAH A 887 (-3.3A)SAH A 887 (-3.5A)SAH A 887 (-4.5A)SO4 A 902 (-2.7A)NoneSAH A 887 ( 3.3A)SAH A 887 (-3.5A)SAH A 887 (-3.9A)SAH A 887 ( 4.2A) | 0.78A | 5wz1G-1r6aA:39.9 | 5wz1G-1r6aA:58.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r6a | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146 | SAH A 887 (-3.0A)SAH A 887 (-3.6A)SAH A 887 (-3.3A)SAH A 887 (-3.5A)SAH A 887 (-4.5A)SO4 A 902 (-2.7A)SO4 A 901 ( 3.9A)NoneSAH A 887 ( 3.3A)SAH A 887 (-3.5A)SAH A 887 (-3.9A) | 0.88A | 5wz1G-1r6aA:39.9 | 5wz1G-1r6aA:58.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rpn | GDP-MANNOSE4,6-DEHYDRATASE (Pseudomonasaeruginosa) |
PF16363(GDP_Man_Dehyd) | 5 | GLY A 212ASP A 215VAL A 214ASP A 274ILE A 273 | GDP A1601 (-3.3A)NoneNoneNoneNone | 0.92A | 5wz1G-1rpnA:undetectable | 5wz1G-1rpnA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 5 | GLY A 297GLY A 239GLY A 299THR A 318ASP A 335 | None | 0.95A | 5wz1G-1vheA:undetectable | 5wz1G-1vheA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wii | HYPOTHETICAL UPF0222PROTEIN MGC4549 (Mus musculus) |
PF05129(Elf1) | 5 | GLY A 46ASP A 73VAL A 70ASP A 40ILE A 61 | None | 1.03A | 5wz1G-1wiiA:undetectable | 5wz1G-1wiiA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2drm | ACANTHAMOEBA MYOSINIB (Acanthamoeba) |
PF00018(SH3_1) | 5 | GLY A 38GLY A 42TRP A 40GLU A 20ILE A 29 | None | 1.00A | 5wz1G-2drmA:undetectable | 5wz1G-2drmA:12.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iu4 | DIHYDROXYACETONEKINASE (Lactococcuslactis) |
PF02733(Dak1) | 5 | GLY A 324GLY A 60THR A 323HIS A 331GLU A 330 | None | 0.94A | 5wz1G-2iu4A:undetectable | 5wz1G-2iu4A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyu | PUTATIVE RIBOSOMALRNAMETHYLTRANSFERASE 2 (Homo sapiens) |
PF01728(FtsJ) | 5 | GLY A 30TRP A 36ASP A 79VAL A 80ASP A 104 | SAM A 201 (-3.5A)SAM A 201 (-3.9A)SAM A 201 (-3.3A)SAM A 201 (-3.9A)SAM A 201 (-3.7A) | 0.40A | 5wz1G-2nyuA:13.9 | 5wz1G-2nyuA:25.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oxt | NUCLEOSIDE-2'-O-METHYLTRANSFERASE (Meaban virus) |
PF01728(FtsJ) | 8 | GLY A 59GLY A 82GLY A 87TRP A 88THR A 105GLU A 112ASP A 132ASP A 147 | SAM A 300 (-3.1A)SAM A 300 (-3.3A)SAM A 300 (-3.2A)SAM A 300 (-3.8A)SAM A 300 (-4.6A)NoneSAM A 300 (-3.9A)SAM A 300 (-3.9A) | 0.44A | 5wz1G-2oxtA:39.4 | 5wz1G-2oxtA:50.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oxt | NUCLEOSIDE-2'-O-METHYLTRANSFERASE (Meaban virus) |
PF01728(FtsJ) | 8 | GLY A 59GLY A 82GLY A 87TRP A 88THR A 105HIS A 111GLU A 112ASP A 147 | SAM A 300 (-3.1A)SAM A 300 (-3.3A)SAM A 300 (-3.2A)SAM A 300 (-3.8A)SAM A 300 (-4.6A)SAM A 300 (-3.6A)NoneSAM A 300 (-3.9A) | 0.47A | 5wz1G-2oxtA:39.4 | 5wz1G-2oxtA:50.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oy0 | METHYLTRANSFERASE (West Nile virus) |
PF01728(FtsJ) | 12 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A 301 (-3.4A)SAH A 301 (-3.0A)SAH A 301 (-3.0A)SAH A 301 (-3.7A)SAH A 301 (-4.4A)NoneSAH A 301 (-4.4A)SAH A 301 (-3.5A)SAH A 301 (-3.2A)SAH A 301 (-3.8A)SAH A 301 (-4.2A)SAH A 301 ( 4.3A) | 0.70A | 5wz1G-2oy0A:40.0 | 5wz1G-2oy0A:68.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p9j | HYPOTHETICAL PROTEINAQ2171 (Aquifexaeolicus) |
PF08282(Hydrolase_3) | 5 | GLY A 144GLY A 18VAL A 75ASP A 41ILE A 45 | None | 0.84A | 5wz1G-2p9jA:undetectable | 5wz1G-2p9jA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pes | URICASE (Aspergillusflavus) |
PF01014(Uricase) | 5 | GLY A 137GLY A 139HIS A 86GLU A 89VAL A 36 | None | 0.99A | 5wz1G-2pesA:undetectable | 5wz1G-2pesA:22.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2px5 | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN) ENVELOPE PROTEIN M(MATRIX PROTEIN) MAJOR ENVELOPEPROTEIN E NON-STRUCTURALPROTEIN 1 (NS1) NON-STRUCTURALPROTEIN 2A (NS2A) FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT NON-STRUCTURALPROTEIN 4A (NS4A) NON-STRUCTURALPROTEIN 4B (NS4B) RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] (Murray Valleyencephalitisvirus) |
PF01728(FtsJ) | 8 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104GLU A 111ASP A 131ASP A 146 | SAH A 500 (-3.3A)SAH A 500 (-3.4A)SAH A 500 (-3.2A)SAH A 500 (-3.4A)SAH A 500 ( 4.6A)SAH A 500 ( 3.2A)SAH A 500 (-3.5A)SAH A 500 (-3.6A) | 0.66A | 5wz1G-2px5A:41.5 | 5wz1G-2px5A:66.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2px5 | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN) ENVELOPE PROTEIN M(MATRIX PROTEIN) MAJOR ENVELOPEPROTEIN E NON-STRUCTURALPROTEIN 1 (NS1) NON-STRUCTURALPROTEIN 2A (NS2A) FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT NON-STRUCTURALPROTEIN 4A (NS4A) NON-STRUCTURALPROTEIN 4B (NS4B) RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] (Murray Valleyencephalitisvirus) |
PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A 500 (-3.3A)SAH A 500 (-3.4A)SAH A 500 (-3.2A)SAH A 500 (-3.4A)SAH A 500 ( 4.6A)SAH A 500 (-3.9A)SAH A 500 (-3.5A)SAH A 500 (-3.6A)SAH A 500 (-3.6A)SAH A 500 ( 4.3A) | 0.51A | 5wz1G-2px5A:41.5 | 5wz1G-2px5A:66.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2px5 | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN) ENVELOPE PROTEIN M(MATRIX PROTEIN) MAJOR ENVELOPEPROTEIN E NON-STRUCTURALPROTEIN 1 (NS1) NON-STRUCTURALPROTEIN 2A (NS2A) FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT NON-STRUCTURALPROTEIN 4A (NS4A) NON-STRUCTURALPROTEIN 4B (NS4B) RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] (Murray Valleyencephalitisvirus) |
PF01728(FtsJ) | 10 | GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A 500 (-3.4A)SAH A 500 (-3.2A)SAH A 500 (-3.4A)SAH A 500 ( 4.6A)NoneSAH A 500 (-3.9A)SAH A 500 (-3.5A)SAH A 500 (-3.6A)SAH A 500 (-3.6A)SAH A 500 ( 4.3A) | 0.74A | 5wz1G-2px5A:41.5 | 5wz1G-2px5A:66.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy6 | UPF0209 PROTEIN YFCK (Escherichiacoli) |
PF05430(Methyltransf_30) | 5 | GLY A 86GLY A 90LYS A 122ASP A 176ASP A 198 | None | 1.04A | 5wz1G-2qy6A:5.5 | 5wz1G-2qy6A:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5o | ALPHA-L-ARABINOFURANOSIDASE (Fusariumgraminearum) |
no annotation | 5 | GLY A 246GLY A 244TRP A 256VAL A 306ILE A 278 | None | 1.04A | 5wz1G-2w5oA:undetectable | 5wz1G-2w5oA:22.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wa2 | NON-STRUCTURALPROTEIN 5 (Modoc virus) |
PF01728(FtsJ) | 10 | GLY A 59GLY A 82TRP A 88THR A 105HIS A 111GLU A 112ASP A 132VAL A 133ASP A 147ILE A 148 | SAM A1248 ( 3.7A)SAM A1248 (-3.3A)SAM A1248 (-3.7A)SAM A1248 (-4.5A)SAM A1248 (-3.8A)NoneSAM A1248 (-3.6A)SAM A1248 (-3.4A)SAM A1248 (-3.7A)SAM A1248 ( 4.0A) | 0.48A | 5wz1G-2wa2A:32.8 | 5wz1G-2wa2A:52.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu8 | GLUCOSE-6-PHOSPHATEISOMERASE (Mycobacteriumtuberculosis) |
PF00342(PGI) | 5 | GLY A 159GLY A 163GLU A 490ASP A 404VAL A 337 | None | 0.94A | 5wz1G-2wu8A:undetectable | 5wz1G-2wu8A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x26 | PERIPLASMICALIPHATICSULPHONATES-BINDINGPROTEIN (Escherichiacoli) |
PF09084(NMT1) | 5 | GLY A 223GLY A 316THR A 312GLU A 220ILE A 226 | None | 0.97A | 5wz1G-2x26A:undetectable | 5wz1G-2x26A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xz3 | MALTOSE ABCTRANSPORTERPERIPLASMIC PROTEIN,ENVELOPEGLYCOPROTEIN (Escherichiacoli;Bovine leukemiavirus) |
PF00429(TLV_coat)PF13416(SBP_bac_8) | 5 | GLY A 286LYS A 323ASP A 322VAL A 319ILE A 37 | None | 1.00A | 5wz1G-2xz3A:undetectable | 5wz1G-2xz3A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yms | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMB (Escherichiacoli) |
PF13360(PQQ_2) | 5 | GLY A 149GLY A 113LYS A 62GLU A 127ILE A 124 | None | 1.01A | 5wz1G-2ymsA:undetectable | 5wz1G-2ymsA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxd | PROBABLECOBALT-PRECORRIN-6YC(15)-METHYLTRANSFERASE[DECARBOXYLATING] (Methanocaldococcusjannaschii) |
PF13847(Methyltransf_31) | 5 | GLY A 68GLY A 90VAL A 95ASP A 64ILE A 63 | None | 1.05A | 5wz1G-2yxdA:9.7 | 5wz1G-2yxdA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yys | PROLINEIMINOPEPTIDASE-RELATED PROTEIN (Thermusthermophilus) |
PF12697(Abhydrolase_6) | 5 | GLY A 62GLU A 14ASP A 19VAL A 56ASP A 84 | None | 1.00A | 5wz1G-2yysA:undetectable | 5wz1G-2yysA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bpu | MEMBRANE-ASSOCIATEDGUANYLATE KINASE, WWAND PDZDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00595(PDZ) | 5 | GLY A 649ASP A 684VAL A 668ASP A 673ILE A 671 | None | 0.94A | 5wz1G-3bpuA:undetectable | 5wz1G-3bpuA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dou | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Thermoplasmavolcanium) |
PF01728(FtsJ) | 5 | GLY A 46GLY A 51TRP A 52ASP A 83ASP A 111 | SAM A 1 (-3.5A)SAM A 1 (-3.2A)SAM A 1 (-4.0A)SAM A 1 (-3.6A)SAM A 1 (-3.7A) | 0.52A | 5wz1G-3douA:13.8 | 5wz1G-3douA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3elu | METHYLTRANSFERASE (Wesselsbronvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110GLU A 111VAL A 132ASP A 146ILE A 147 | SAM A4633 ( 3.7A)SAM A4633 (-3.2A)SAM A4633 (-3.4A)SAM A4633 (-3.5A)SAM A4633 (-4.5A)SAM A4633 (-3.6A)NoneSAM A4633 (-3.4A)SAM A4633 (-3.7A)SAM A4633 ( 4.2A) | 0.72A | 5wz1G-3eluA:39.1 | 5wz1G-3eluA:53.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3evc | RNA-DIRECTED RNAPOLYMERASE NS5 (Yellow fevervirus) |
PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110ASP A 131ASP A 146ILE A 147 | SAH A 901 (-3.2A)SAH A 901 (-3.4A)SAH A 901 (-3.1A)SAH A 901 (-3.6A)SAH A 901 (-4.5A)SAH A 901 (-3.8A)SAH A 901 (-3.7A)SAH A 901 (-3.8A)SAH A 901 ( 4.2A) | 0.34A | 5wz1G-3evcA:41.3 | 5wz1G-3evcA:52.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3evc | RNA-DIRECTED RNAPOLYMERASE NS5 (Yellow fevervirus) |
PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110GLU A 111ASP A 131ASP A 146 | SAH A 901 (-3.2A)SAH A 901 (-3.4A)SAH A 901 (-3.1A)SAH A 901 (-3.6A)SAH A 901 (-4.5A)SAH A 901 (-3.8A)SAH A 901 (-3.1A)SAH A 901 (-3.7A)SAH A 901 (-3.8A) | 0.74A | 5wz1G-3evcA:41.3 | 5wz1G-3evcA:52.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3evc | RNA-DIRECTED RNAPOLYMERASE NS5 (Yellow fevervirus) |
PF01728(FtsJ) | 6 | GLY A 86TRP A 87HIS A 110ASP A 131ASP A 146ILE A 147 | SAH A 901 (-3.1A)SAH A 901 (-3.6A)SAH A 901 (-3.8A)SAH A 901 (-3.7A)SAH A 901 (-3.8A)SAH A 901 ( 4.2A) | 1.40A | 5wz1G-3evcA:41.3 | 5wz1G-3evcA:52.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gcz | POLYPROTEIN (Yokose virus) |
PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A4633 (-3.5A)SAM A4633 (-3.4A)SAM A4633 (-3.2A)SAM A4633 (-3.6A)SAM A4633 (-4.5A)SAM A4633 (-3.5A)SAM A4633 (-3.7A)SAM A4633 (-3.6A)SAM A4633 (-3.7A)SAM A4633 ( 4.2A) | 0.45A | 5wz1G-3gczA:41.3 | 5wz1G-3gczA:54.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gcz | POLYPROTEIN (Yokose virus) |
PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110GLU A 111VAL A 132ASP A 146ILE A 147 | SAM A4633 (-3.5A)SAM A4633 (-3.4A)SAM A4633 (-3.2A)SAM A4633 (-3.6A)SAM A4633 (-4.5A)SAM A4633 (-3.5A)NoneSAM A4633 (-3.6A)SAM A4633 (-3.7A)SAM A4633 ( 4.2A) | 0.65A | 5wz1G-3gczA:41.3 | 5wz1G-3gczA:54.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gcz | POLYPROTEIN (Yokose virus) |
PF01728(FtsJ) | 6 | GLY A 86TRP A 87HIS A 110ASP A 131ASP A 146ILE A 147 | SAM A4633 (-3.2A)SAM A4633 (-3.6A)SAM A4633 (-3.5A)SAM A4633 (-3.7A)SAM A4633 (-3.7A)SAM A4633 ( 4.2A) | 1.49A | 5wz1G-3gczA:41.3 | 5wz1G-3gczA:54.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gd5 | ORNITHINECARBAMOYLTRANSFERASE (Gloeobacterviolaceus) |
PF00185(OTCace)PF02729(OTCace_N) | 6 | GLY A 48GLY A 106GLY A 75ASP A 15ASP A 105ILE A 126 | None | 1.31A | 5wz1G-3gd5A:3.9 | 5wz1G-3gd5A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h41 | NLP/P60 FAMILYPROTEIN (Bacillus cereus) |
PF00877(NLPC_P60) | 5 | GLY A 235GLY A 218GLY A 233THR A 217ILE A 302 | None | 0.87A | 5wz1G-3h41A:undetectable | 5wz1G-3h41A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kuu | PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASECATALYTIC SUBUNITPURE (Yersinia pestis) |
PF00731(AIRC) | 5 | GLY A 122GLY A 95LYS A 14HIS A 69VAL A 40 | None | 0.92A | 5wz1G-3kuuA:undetectable | 5wz1G-3kuuA:21.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lkz | NON-STRUCTURALPROTEIN 5 (West Nile virus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SFG A 301 (-2.9A)SFG A 301 (-3.5A)SFG A 301 (-3.4A)SFG A 301 (-3.7A)SFG A 301 ( 4.7A)NoneSFG A 301 (-3.9A)SFG A 301 (-3.1A)SFG A 301 (-4.1A)SFG A 301 (-3.8A)SFG A 301 (-4.1A) | 0.45A | 5wz1G-3lkzA:41.6 | 5wz1G-3lkzA:61.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lkz | NON-STRUCTURALPROTEIN 5 (West Nile virus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111VAL A 132ASP A 146ILE A 147 | SFG A 301 (-2.9A)SFG A 301 (-3.5A)SFG A 301 (-3.4A)SFG A 301 (-3.7A)SFG A 301 ( 4.7A)NoneSFG A 301 (-3.9A)SFG A 301 (-3.7A)SFG A 301 (-4.1A)SFG A 301 (-3.8A)SFG A 301 (-4.1A) | 0.59A | 5wz1G-3lkzA:41.6 | 5wz1G-3lkzA:61.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n94 | FUSION PROTEIN OFMALTOSE-BINDINGPERIPLASMIC PROTEINAND PITUITARYADENYLATE CYCLASE 1RECEPTOR-SHORT (Escherichiacoli;Homo sapiens) |
PF02793(HRM)PF13416(SBP_bac_8) | 5 | GLY A -88LYS A -51ASP A -52VAL A -55ILE A-337 | None | 1.04A | 5wz1G-3n94A:undetectable | 5wz1G-3n94A:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oai | MALTOSE-BINDINGPERIPLASMIC PROTEIN,MYELIN PROTEIN P0 (Escherichiacoli;Homo sapiens) |
PF07686(V-set)PF13416(SBP_bac_8) | 5 | GLY A 260LYS A 297ASP A 296VAL A 293ILE A 11 | None | 1.03A | 5wz1G-3oaiA:undetectable | 5wz1G-3oaiA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pea | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Bacillusanthracis) |
PF00378(ECH_1) | 5 | GLY A 62GLY A 84GLY A 110THR A 87HIS A 32 | None | 0.66A | 5wz1G-3peaA:undetectable | 5wz1G-3peaA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ps9 | TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC (Escherichiacoli) |
PF01266(DAO)PF05430(Methyltransf_30) | 5 | GLY A 66GLY A 70LYS A 102ASP A 156ASP A 178 | SAM A 670 (-3.5A)SAM A 670 ( 4.5A)SAM A 670 (-4.9A)SAM A 670 (-3.5A)SAM A 670 (-3.4A) | 0.93A | 5wz1G-3ps9A:4.2 | 5wz1G-3ps9A:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvc | TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC (Yersinia pestis) |
PF01266(DAO)PF05430(Methyltransf_30) | 6 | GLY A 66GLY A 70LYS A 102ASP A 156VAL A 157ASP A 178 | None | 0.95A | 5wz1G-3pvcA:4.9 | 5wz1G-3pvcA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r8e | HYPOTHETICAL SUGARKINASE (Cytophagahutchinsonii) |
PF00480(ROK) | 5 | GLY A 115GLY A 62GLY A 290GLU A 106ILE A 298 | None | 0.80A | 5wz1G-3r8eA:undetectable | 5wz1G-3r8eA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3soe | MEMBRANE-ASSOCIATEDGUANYLATE KINASE, WWAND PDZDOMAIN-CONTAININGPROTEIN 3 (Homo sapiens) |
no annotation | 5 | GLY A 609ASP A 642VAL A 626ASP A 631ILE A 629 | None | 1.05A | 5wz1G-3soeA:undetectable | 5wz1G-3soeA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmy | EXTRACELLULAREXO-ALPHA-L-ARABINOFURANOSIDASE (Streptomycescoelicolor) |
PF03664(Glyco_hydro_62) | 6 | GLY A 382GLY A 385HIS A 427GLU A 361ASP A 429ILE A 377 | NoneNone CA A 501 ( 3.6A)TRS A 503 (-2.9A)NoneNone | 1.46A | 5wz1G-3wmyA:undetectable | 5wz1G-3wmyA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4auk | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE M (Escherichiacoli) |
PF01728(FtsJ) | 5 | GLY A 219GLY A 224TRP A 225ASP A 260ASP A 277 | EDO A1373 (-3.8A)NoneNoneNoneNone | 0.78A | 5wz1G-4aukA:12.7 | 5wz1G-4aukA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4t | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Burkholderiaambifaria) |
PF02222(ATP-grasp) | 5 | GLY A 161GLY A 166HIS A 130GLU A 191ILE A 114 | None | 1.04A | 5wz1G-4e4tA:2.0 | 5wz1G-4e4tA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exr | PUTATIVE LIPOPROTEIN (Clostridioidesdifficile) |
PF03413(PepSY) | 6 | GLY A 132GLY A 99GLU A 137VAL A 97ASP A 80ILE A 81 | None | 1.21A | 5wz1G-4exrA:undetectable | 5wz1G-4exrA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr9 | UNCHARACTERIZEDPROTEIN (Bacteroidesfragilis) |
PF11396(PepSY_like) | 5 | GLY A 146GLY A 148GLU A 105VAL A 113ILE A 92 | None | 0.99A | 5wz1G-4fr9A:undetectable | 5wz1G-4fr9A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 5 | GLY A 63GLY A 68LYS A 86ASP A 111VAL A 112 | ACT A 402 (-3.4A)NoneNoneNoneNone | 0.87A | 5wz1G-4gc5A:8.0 | 5wz1G-4gc5A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gkv | ALCOHOLDEHYDROGENASE,PROPANOL-PREFERRING (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 328GLY A 147GLY A 171THR A 149ILE A 143 | NoneNoneNAD A 401 (-3.2A)NAD A 401 (-3.3A)None | 0.97A | 5wz1G-4gkvA:3.6 | 5wz1G-4gkvA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikh | GLUTATHIONES-TRANSFERASE (Pseudomonasprotegens) |
PF00043(GST_C)PF02798(GST_N) | 5 | GLY A 134GLY A 131ASP A 165VAL A 211ILE A 205 | NoneGSH A 303 (-3.3A)NoneNoneNone | 0.88A | 5wz1G-4ikhA:undetectable | 5wz1G-4ikhA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86THR A 104HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.1A)SAH A1001 (-3.3A)SAH A1001 (-3.2A)SAH A1001 (-4.7A)SAH A1001 ( 3.6A)SAH A1001 (-3.7A)SAH A1001 (-3.7A)SAH A1001 (-3.6A)SAH A1001 ( 4.3A) | 0.41A | 5wz1G-4k6mA:41.3 | 5wz1G-4k6mA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146 | SAH A1001 (-3.1A)SAH A1001 (-3.3A)SAH A1001 (-3.2A)SAH A1001 (-4.7A)SAH A1001 ( 3.6A)SO4 A1011 (-4.9A)SAH A1001 (-3.7A)SAH A1001 (-3.7A)SAH A1001 (-3.6A) | 0.68A | 5wz1G-4k6mA:41.3 | 5wz1G-4k6mA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86THR A 104LYS A 105ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.1A)SAH A1001 (-3.3A)SAH A1001 (-3.2A)SAH A1001 (-4.7A)NoneSAH A1001 (-3.7A)SAH A1001 (-3.7A)SAH A1001 (-3.6A)SAH A1001 ( 4.3A) | 0.60A | 5wz1G-4k6mA:41.3 | 5wz1G-4k6mA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110GLU A 111VAL A 132ASP A 146 | SAH A1001 (-3.1A)SAH A1001 (-3.3A)SAH A1001 (-3.2A)SAH A1001 (-3.9A)SAH A1001 (-4.7A)SAH A1001 ( 3.6A)SO4 A1011 (-4.9A)SAH A1001 (-3.7A)SAH A1001 (-3.6A) | 0.79A | 5wz1G-4k6mA:41.3 | 5wz1G-4k6mA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.1A)SAH A1001 (-3.3A)SAH A1001 (-3.2A)SAH A1001 (-3.9A)SAH A1001 (-4.7A)SAH A1001 ( 3.6A)SAH A1001 (-3.7A)SAH A1001 (-3.6A)SAH A1001 ( 4.3A) | 0.58A | 5wz1G-4k6mA:41.3 | 5wz1G-4k6mA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfn | GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNITAGALACTOSE-6-PHOSPHATE ISOMERASE SUBUNITB (Lactobacillusrhamnosus;Lactobacillusrhamnosus) |
PF02502(LacAB_rpiB)PF02502(LacAB_rpiB) | 5 | GLY B 46GLY B 66THR B 67HIS A 96ILE B 10 | NoneRBL B 201 (-3.4A)RBL B 201 (-3.4A)RBL B 201 (-3.7A)RBL B 201 (-4.1A) | 0.92A | 5wz1G-4lfnB:undetectable | 5wz1G-4lfnB:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nf2 | ORNITHINECARBAMOYLTRANSFERASE (Bacillusanthracis) |
PF00185(OTCace)PF02729(OTCace_N) | 6 | GLY A 46GLY A 104GLY A 73ASP A 13ASP A 103ILE A 124 | None | 1.27A | 5wz1G-4nf2A:3.2 | 5wz1G-4nf2A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qc8 | VP2 (Ungulatebocaparvovirus1) |
PF00740(Parvo_coat) | 5 | GLY A 347GLY A 302THR A 433LYS A 432ASP A 436 | None | 1.03A | 5wz1G-4qc8A:undetectable | 5wz1G-4qc8A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tz5 | PUTATIVE SECRETEDPROTEIN (Streptomycessp. SirexAA-E) |
no annotation | 5 | GLY A 166GLY A 185THR A 132ASP A 136ILE A 111 | NoneNoneNoneBGC A 709 ( 4.5A)None | 1.00A | 5wz1G-4tz5A:undetectable | 5wz1G-4tz5A:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u36 | SEED LECTIN (Vataireamacrocarpa) |
PF00139(Lectin_legB) | 5 | GLY A 105GLY A 139GLU A 146VAL A 189ASP A 125 | TNR A 303 (-3.2A)NoneNoneNone CA A 302 ( 2.1A) | 0.99A | 5wz1G-4u36A:undetectable | 5wz1G-4u36A:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6z | ALCOHOLDEHYDROGENASE 1 (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 339GLY A 155GLY A 180THR A 157ILE A 151 | NoneNone8ID A 403 (-3.0A)8ID A 403 (-2.9A)None | 1.02A | 5wz1G-4w6zA:4.1 | 5wz1G-4w6zA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcq | TUBZ (Clostridiumphage c-st) |
PF00091(Tubulin) | 5 | GLY A 57GLY A 101GLY A 59THR A 95ILE A 10 | NoneGDP A 401 (-3.3A)NoneGDP A 401 (-3.0A)None | 0.89A | 5wz1G-4xcqA:undetectable | 5wz1G-4xcqA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a1n | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASEAMINOACYL TRNASYNTHASECOMPLEX-INTERACTINGMULTIFUNCTIONALPROTEIN 2 (Homo sapiens;Homo sapiens) |
PF00043(GST_C)PF00043(GST_C) | 5 | GLY B 211GLY B 209VAL A 113ASP A 79ILE A 78 | None | 0.95A | 5wz1G-5a1nB:undetectable | 5wz1G-5a1nB:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ccx | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRMT61A (Homo sapiens) |
PF08704(GCD14) | 6 | GLY A 111GLY A 115ASP A 163VAL A 164ASP A 181ILE A 182 | SAH A 301 (-3.2A)SAH A 301 (-3.9A)SAH A 301 (-2.7A)SAH A 301 (-4.0A)SAH A 301 (-2.4A)SAH A 301 ( 3.8A) | 0.88A | 5wz1G-5ccxA:8.8 | 5wz1G-5ccxA:22.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e9q | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 301 (-3.2A)SAM A 301 (-3.3A)SAM A 301 (-3.1A)SAM A 301 (-3.6A)SAM A 301 (-4.6A)NoneSAM A 301 ( 3.7A)SAM A 301 (-3.4A)SAM A 301 (-3.6A)SAM A 301 (-3.8A)SAM A 301 ( 4.2A) | 0.34A | 5wz1G-5e9qA:41.4 | 5wz1G-5e9qA:65.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e9q | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131 | SAM A 301 (-3.2A)SAM A 301 (-3.3A)SAM A 301 (-3.1A)SAM A 301 (-3.6A)SAM A 301 (-4.6A)NoneSAM A 301 ( 3.7A)SAM A 301 ( 3.4A)SAM A 301 (-3.4A) | 0.69A | 5wz1G-5e9qA:41.4 | 5wz1G-5e9qA:65.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e9q | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 7 | GLY A 86TRP A 87LYS A 105HIS A 110ASP A 131ASP A 146ILE A 147 | SAM A 301 (-3.1A)SAM A 301 (-3.6A)NoneSAM A 301 ( 3.7A)SAM A 301 (-3.4A)SAM A 301 (-3.8A)SAM A 301 ( 4.2A) | 1.40A | 5wz1G-5e9qA:41.4 | 5wz1G-5e9qA:65.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5erg | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRM61 (Saccharomycescerevisiae) |
PF08704(GCD14) | 5 | GLY B 118GLY B 122ASP B 168VAL B 169ASP B 203 | SAM B 401 (-3.4A)SAM B 401 (-3.9A)SAM B 401 (-3.5A)SAM B 401 (-3.7A)SAM B 401 (-3.3A) | 1.01A | 5wz1G-5ergB:8.6 | 5wz1G-5ergB:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ghf | AMINOTRANSFERASECLASS-III (Ochrobactrumanthropi) |
PF00202(Aminotran_3) | 5 | GLY A 272GLY A 263GLU A 225VAL A 125ILE A 256 | NoneNonePMP A 501 (-3.9A)NoneNone | 0.89A | 5wz1G-5ghfA:undetectable | 5wz1G-5ghfA:18.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikm | NS5 METHYLTRANSFERASE (Dengue virus) |
PF01728(FtsJ) | 12 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 311 (-3.3A)SAM A 311 (-3.2A)SAM A 311 (-3.3A)SAM A 311 (-3.5A)SAM A 311 (-4.5A)MLT A 313 ( 3.0A)SAM A 311 (-4.1A)NoneMLT A 313 ( 2.6A)SAM A 311 (-3.7A)SAM A 311 (-3.8A)SAM A 311 ( 4.3A) | 0.72A | 5wz1G-5ikmA:40.8 | 5wz1G-5ikmA:60.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j72 | PUTATIVEN-ACETYLMURAMOYL-L-ALANINEAMIDASE,AUTOLYSINCWP6 (Clostridioidesdifficile) |
PF01520(Amidase_3)PF04122(CW_binding_2) | 5 | GLY A 278GLY A 179GLY A 275VAL A 171ILE A 387 | None | 0.93A | 5wz1G-5j72A:undetectable | 5wz1G-5j72A:19.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1003 (-3.2A)SAH A1003 (-3.4A)SAH A1003 (-3.0A)SAH A1003 (-3.4A)SAH A1003 (-4.6A)SAH A1003 (-4.8A)SAH A1003 (-3.7A)SAH A1003 (-3.0A)SAH A1003 (-3.7A)SAH A1003 (-3.8A)SAH A1003 ( 4.3A) | 0.47A | 5wz1G-5jjrA:40.9 | 5wz1G-5jjrA:63.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 146 | SAH A1003 (-3.2A)SAH A1003 (-3.4A)SAH A1003 (-3.0A)SAH A1003 (-3.4A)SAH A1003 (-4.6A)SAH A1003 (-4.8A)SAH A1003 (-3.7A)SAH A1003 (-3.3A)SAH A1003 (-3.8A) | 0.73A | 5wz1G-5jjrA:40.9 | 5wz1G-5jjrA:63.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l5n | PLEXIN-A4 (Mus musculus) |
PF01403(Sema)PF01437(PSI)PF01833(TIG) | 5 | GLY A 420GLY A 298GLU A 416VAL A 293ILE A 366 | GLY A 420 ( 0.0A)GLY A 298 ( 0.0A)GLU A 416 ( 0.5A)VAL A 293 ( 0.6A)ILE A 366 ( 0.6A) | 0.97A | 5wz1G-5l5nA:undetectable | 5wz1G-5l5nA:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m41 | NIGRITOXINE (Vibrionigripulchritudo) |
no annotation | 6 | GLY A 612GLY A 623TRP A 628THR A 615VAL A 684ILE A 610 | None | 1.48A | 5wz1G-5m41A:undetectable | 5wz1G-5m41A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nju | GENOME POLYPROTEIN (Zika virus) |
no annotation | 10 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110GLU A 111VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.3A)SAH A1001 (-3.4A)SAH A1001 (-3.3A)SAH A1001 (-3.5A)SAH A1001 (-4.4A)SAH A1001 (-4.0A)NoneSAH A1001 (-3.6A)SAH A1001 (-3.7A)SAH A1001 (-4.2A) | 0.60A | 5wz1G-5njuA:42.9 | 5wz1G-5njuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nju | GENOME POLYPROTEIN (Zika virus) |
no annotation | 10 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104LYS A 105ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.3A)SAH A1001 (-3.4A)SAH A1001 (-3.3A)SAH A1001 (-3.5A)SAH A1001 (-4.4A)NoneSAH A1001 (-3.9A)SAH A1001 (-3.6A)SAH A1001 (-3.7A)SAH A1001 (-4.2A) | 0.60A | 5wz1G-5njuA:42.9 | 5wz1G-5njuA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tmh | POLYPROTEIN (Zika virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 86TRP A 87THR A 104HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.2A)SAH A1001 (-3.4A)SAH A1001 (-3.6A)SAH A1001 (-3.5A)SAH A1001 ( 4.9A)SAH A1001 (-3.6A)SAH A1001 (-4.0A)SAH A1001 (-4.0A)SAH A1001 (-3.8A)SAH A1001 ( 4.8A) | 0.35A | 5wz1G-5tmhA:42.7 | 5wz1G-5tmhA:94.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tmh | POLYPROTEIN (Zika virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 86TRP A 87THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146 | SAH A1001 (-3.2A)SAH A1001 (-3.6A)SAH A1001 (-3.5A)SAH A1001 ( 4.9A)SAH A1001 (-3.6A)NoneSAH A1001 (-4.0A)SAH A1001 (-4.0A)SAH A1001 (-3.8A) | 0.73A | 5wz1G-5tmhA:42.7 | 5wz1G-5tmhA:94.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tok | SINGLE-DOMAINANTIBODY F-VHH-L66 (Lama glama) |
PF07686(V-set) | 5 | GLY D 100GLY D 35GLY D 100VAL D 78ILE D 51 | None | 1.03A | 5wz1G-5tokD:undetectable | 5wz1G-5tokD:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4q | DTDP-GLUCOSE4,6-DEHYDRATASE (Klebsiellapneumoniae) |
PF16363(GDP_Man_Dehyd) | 5 | GLY A 183GLY A 13GLY A 186VAL A 5ILE A 16 | CL A 402 (-4.3A)None CL A 402 ( 4.4A)NoneNone | 0.85A | 5wz1G-5u4qA:5.9 | 5wz1G-5u4qA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubj | ALPHA-L-ARABINOFURANOSIDASE AXHA-2 (Aspergillusnidulans) |
PF03664(Glyco_hydro_62) | 6 | GLY A 233GLY A 236HIS A 278GLU A 210ASP A 280ILE A 228 | NoneNone CA A 401 (-3.7A) CA A 403 ( 4.2A)NoneNone | 1.46A | 5wz1G-5ubjA:undetectable | 5wz1G-5ubjA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 5 | GLY A 348GLY A 444GLY A 438HIS A 453ASP A 24 | None | 0.98A | 5wz1G-5upyA:undetectable | 5wz1G-5upyA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uxb | MACROLIDE2'-PHOSPHOTRANSFERASE MPHH (Brachybacteriumfaecium) |
PF01636(APH) | 5 | GLY A 256GLY A 184TRP A 254GLU A 263ASP A 158 | None | 0.92A | 5wz1G-5uxbA:undetectable | 5wz1G-5uxbA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xg9 | UNCONVENTIONALMYOSIN IB (Entamoebahistolytica) |
no annotation | 5 | GLY B 35GLY B 39TRP B 37GLU B 18ILE B 27 | 1PE B 101 (-4.1A)NoneNonePEU B 102 (-4.4A)None | 0.97A | 5wz1G-5xg9B:undetectable | 5wz1G-5xg9B:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0r | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY1,VIRAL GENOMEPROTEIN (Escherichiacoli) |
no annotation | 5 | GLY A 261LYS A 298ASP A 297VAL A 294ILE A 12 | MAL A 501 ( 4.8A)NoneNoneNoneNone | 1.01A | 5wz1G-5z0rA:undetectable | 5wz1G-5z0rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6amn | HEAT SHOCK PROTEIN104 (Saccharomycescerevisiae) |
no annotation | 5 | GLY A 212GLY A 314THR A 317GLU A 285ILE A 216 | None | 1.03A | 5wz1G-6amnA:2.1 | 5wz1G-6amnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | PROBABLEMEMBRANE-BOUNDHYDROGENASE SUBUNITMBHJMEMBRANE-BOUNDHYDROGENASE SUBUNITALPHA (Pyrococcusfuriosus;Pyrococcusfuriosus) |
no annotationno annotation | 5 | GLY J 37GLY J 33VAL L 150ASP J 39ILE J 40 | SF4 J 201 ( 4.6A)NoneNoneNoneNone | 0.99A | 5wz1G-6cfwJ:undetectable | 5wz1G-6cfwJ:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6day | DIHYDROPTEROATESYNTHASE (Xanthomonasalbilineans) |
no annotation | 5 | GLY A 24HIS A 249ASP A 264ASP A 61ILE A 25 | NoneNoneNoneNoneSO4 A 403 (-4.3A) | 0.85A | 5wz1G-6dayA:undetectable | 5wz1G-6dayA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fik | POLYKETIDE SYNTHASE (Cercosporanicotianae) |
no annotation | 5 | GLY A 732GLY A 440GLY A 617GLU A 414VAL A 427 | None | 0.83A | 5wz1G-6fikA:undetectable | 5wz1G-6fikA:undetectable |