SIMILAR PATTERNS OF AMINO ACIDS FOR 5WYQ_A_SAMA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLN A  87
GLY A 351
ILE A 190
GLY A 193
GLY A 192
 None
 1.10A 5wyqA-1e5mA:
undetectable		 5wyqA-1e5mA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 ILE A 209
LEU A  49
GLY A  46
GLY A  45
PRO A 192
 None
 1.06A 5wyqA-1fztA:
undetectable		 5wyqA-1fztA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 GLY A 216
GLY A  88
VAL A  37
GLY A  46
GLY A  47
 None
 0.95A 5wyqA-1jxnA:
undetectable		 5wyqA-1jxnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 GLY A 419
GLY A  62
SER A  66
LEU A 408
GLY A 407
 None
 1.02A 5wyqA-1m7jA:
undetectable		 5wyqA-1m7jA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A  98
GLY A  96
ILE A  47
GLY A  91
GLY A  62
 None
 1.00A 5wyqA-1o8cA:
undetectable		 5wyqA-1o8cA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		5 GLY A  54
GLY A  26
ILE A  69
GLY A  59
GLY A  61
 None
 1.11A 5wyqA-1opeA:
undetectable		 5wyqA-1opeA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 115
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.28A 5wyqA-1oy5A:
19.6		 5wyqA-1oy5A:
38.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		12 LEU A  87
PRO A  89
GLN A  90
GLY A 113
GLY A 117
SER A 132
ILE A 133
VAL A 137
LEU A 138
GLY A 140
GLY A 141
PRO A 144
 SAH  A 300 (-4.4A)
SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.6A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.4A)
SAH  A 300 ( 4.0A)
SAH  A 300 (-4.1A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.5A)
SAH  A 300 (-4.5A)
 0.26A 5wyqA-1p9pA:
29.2		 5wyqA-1p9pA:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		6 LEU A  87
PRO A  89
GLN A  90
SER A 132
GLY A 113
GLY A 141
 SAH  A 300 (-4.4A)
SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.6A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.5A)
 1.47A 5wyqA-1p9pA:
29.2		 5wyqA-1p9pA:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  89
GLN A  90
GLY A 113
GLY A 117
LEU A 138
GLY A 141
 SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.1A)
SAH  A 300 (-3.5A)
 1.25A 5wyqA-1p9pA:
29.2		 5wyqA-1p9pA:
62.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 GLY A  16
GLY A  22
ILE A  76
VAL A  12
GLY A  38
 NAD  A 360 (-3.4A)
None
None
None
None
 1.09A 5wyqA-1rkxA:
undetectable		 5wyqA-1rkxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 GLY A  49
SER A  89
GLY A  46
GLY A  47
PRO A 134
 None
SO4  A 709 (-3.1A)
None
SO4  A 709 ( 4.8A)
SO4  A 709 (-4.2A)
 0.88A 5wyqA-1tzbA:
undetectable		 5wyqA-1tzbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca;
Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU)
PF02288
(Dehydratase_MU) 		5 GLN B 197
GLY A 261
SER A 307
ILE A 313
GLY A 298
 CNC  B2601 ( 4.6A)
NH4  A2604 (-4.1A)
None
None
None
 1.03A 5wyqA-1uc4B:
undetectable		 5wyqA-1uc4B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8c MOAD RELATED PROTEIN

(Thermus
thermophilus) 		PF02597
(ThiS)
PF09189
(DUF1952) 		5 GLY A 149
GLY A 122
VAL A  84
GLY A  86
GLY A  87
 None
 0.98A 5wyqA-1v8cA:
undetectable		 5wyqA-1v8cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 156
GLY A 162
VAL A 152
LEU A 177
GLY A 178
 NAP  A 801 ( 3.1A)
CL  A 816 (-3.3A)
None
None
None
 1.07A 5wyqA-1yb5A:
undetectable		 5wyqA-1yb5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 159
ILE A 131
VAL A  47
GLY A 160
PRO A 132
 CL  A 816 ( 3.1A)
NAP  A 801 (-4.5A)
None
NAP  A 801 ( 3.9A)
None
 0.98A 5wyqA-1yb5A:
undetectable		 5wyqA-1yb5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PRO A 244
GLY A 530
GLY A 318
ILE A 110
GLY A 527
 None
None
AMP  A1001 (-3.5A)
None
None
 0.99A 5wyqA-2d1qA:
undetectable		 5wyqA-2d1qA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d74 TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT

(Pyrococcus
furiosus) 		PF01873
(eIF-5_eIF-2B) 		5 GLY B  41
ILE B  93
VAL B  83
LEU B  84
GLY B  86
 None
 0.93A 5wyqA-2d74B:
undetectable		 5wyqA-2d74B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 193
GLY A 198
ILE A 246
VAL A 213
GLY A 216
 NAD  A1403 (-3.4A)
None
None
None
None
 1.00A 5wyqA-2dphA:
undetectable		 5wyqA-2dphA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		5 GLY A 123
GLY A 145
ILE A 232
GLY A 218
GLY A 217
 None
 0.98A 5wyqA-2f9tA:
undetectable		 5wyqA-2f9tA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 843
ILE A 883
VAL A 849
GLY A 855
GLY A 856
 None
 0.85A 5wyqA-2fgeA:
undetectable		 5wyqA-2fgeA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		5 GLY A 145
GLY A 129
ILE A 188
LEU A 159
GLY A 161
 None
 1.08A 5wyqA-2g8sA:
undetectable		 5wyqA-2g8sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.70A 5wyqA-2gzsA:
undetectable		 5wyqA-2gzsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 661
GLY A 689
GLY A 659
GLY A 660
PRO A 445
 None
 1.07A 5wyqA-2ipcA:
undetectable		 5wyqA-2ipcA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 PRO A 261
GLY A 197
GLY A 357
GLY A 199
GLY A 200
 None
None
None
ASP  A 502 (-3.1A)
ASP  A 502 (-4.2A)
 0.68A 5wyqA-2j0wA:
undetectable		 5wyqA-2j0wA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 GLY A  37
VAL A 112
GLY A  39
GLY A  40
PRO A  43
 SO4  A 301 ( 4.1A)
5GP  A 300 (-4.9A)
None
None
None
 1.02A 5wyqA-2jkyA:
undetectable		 5wyqA-2jkyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbw H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A 110
GLY A 114
SER A 121
ILE A  81
GLY A 111
 None
 0.91A 5wyqA-2lbwA:
undetectable		 5wyqA-2lbwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 LEU A 211
GLY A 337
ILE A 223
GLY A 213
GLY A 212
 None
ATP  A 500 (-3.1A)
None
ATP  A 500 (-2.8A)
None
 1.05A 5wyqA-2paaA:
undetectable		 5wyqA-2paaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 210
GLY A 212
SER A  97
ILE A 463
GLY A  94
 None
 1.02A 5wyqA-2wyaA:
undetectable		 5wyqA-2wyaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 GLY A 137
GLY A 143
ILE A 191
GLY A 162
GLY A 163
 None
 0.96A 5wyqA-2y27A:
undetectable		 5wyqA-2y27A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 GLN A 414
GLY A  65
GLY A 118
GLY A  67
GLY A  68
 FAD  A 801 ( 3.1A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.2A)
FAD  A 801 (-3.4A)
None
 1.00A 5wyqA-2yr5A:
undetectable		 5wyqA-2yr5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 PRO A 411
GLN A 414
GLY A  65
GLY A 118
GLY A  67
 FAD  A 801 (-4.2A)
FAD  A 801 ( 3.1A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.2A)
FAD  A 801 (-3.4A)
 0.91A 5wyqA-2yr5A:
undetectable		 5wyqA-2yr5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 GLY A  96
GLY A 155
ILE A  40
GLY A  99
GLY A  98
 None
 1.10A 5wyqA-3ai7A:
undetectable		 5wyqA-3ai7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		5 GLY A 182
GLY A 282
ILE A 178
LEU A 292
GLY A 310
 None
 1.07A 5wyqA-3btuA:
undetectable		 5wyqA-3btuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 LEU A 281
GLY A 279
LEU A 274
GLY A 275
GLY A 277
 None
 1.10A 5wyqA-3dwiA:
undetectable		 5wyqA-3dwiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 LEU A 281
GLY A 279
LEU A 274
GLY A 277
PRO A  24
 None
 1.02A 5wyqA-3dwiA:
undetectable		 5wyqA-3dwiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Brucella suis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 LEU A 165
ILE A 185
VAL A 208
LEU A 209
GLY A 192
 None
 0.88A 5wyqA-3eg4A:
undetectable		 5wyqA-3eg4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		5 GLY A  86
ILE A  70
LEU A  83
GLY A  84
GLY A 225
 PO4  A 362 (-3.4A)
None
None
None
None
 0.95A 5wyqA-3ftbA:
undetectable		 5wyqA-3ftbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i99 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Vibrio cholerae) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 LEU A  58
GLY A  74
ILE A  60
VAL A  35
LEU A  34
 FAD  A 358 ( 4.9A)
None
FAD  A 358 (-4.0A)
None
None
 0.80A 5wyqA-3i99A:
undetectable		 5wyqA-3i99A:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		7 PRO A  87
GLY A 111
SER A 130
ILE A 131
LEU A 136
GLY A 138
GLY A 139
 None
 0.58A 5wyqA-3iefA:
21.5		 5wyqA-3iefA:
42.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF01960
(ArgJ)
PF01960
(ArgJ) 		5 GLY A  15
GLY A 157
LEU B 205
GLY A 186
GLY A 185
 None
 1.12A 5wyqA-3it4A:
undetectable		 5wyqA-3it4A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		9 PRO A  88
GLY A 112
GLY A 116
SER A 131
ILE A 132
VAL A 136
LEU A 137
GLY A 139
GLY A 140
 None
 0.36A 5wyqA-3knuA:
21.5		 5wyqA-3knuA:
41.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 143
GLY A 140
VAL A 279
GLY A 245
GLY A 242
 None
 1.04A 5wyqA-3kuxA:
undetectable		 5wyqA-3kuxA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  87
GLY A 111
LEU A 136
GLY A 138
GLY A 139
PRO A 142
 OCS  A  86 ( 2.5A)
None
None
None
None
None
 0.66A 5wyqA-3ky7A:
20.2		 5wyqA-3ky7A:
39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		7 PRO A  87
SER A 130
VAL A 135
LEU A 136
GLY A 138
GLY A 139
PRO A 142
 OCS  A  86 ( 2.5A)
OCS  A  86 ( 3.8A)
None
None
None
None
None
 0.72A 5wyqA-3ky7A:
20.2		 5wyqA-3ky7A:
39.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmg NUCLEAR INCLUSION
PROTEIN A

(Tobacco vein
mottling virus) 		PF00863
(Peptidase_C4) 		5 GLY A 152
ILE A 131
VAL A 156
LEU A 164
GLY A 165
 None
 1.11A 5wyqA-3mmgA:
undetectable		 5wyqA-3mmgA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 GLY K  99
GLY K  56
ILE K 122
VAL K  88
LEU K  87
 None
 0.91A 5wyqA-3mvdK:
undetectable		 5wyqA-3mvdK:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 LEU A 208
GLY A 206
GLY A 164
ILE A 281
GLY A 243
 None
 1.06A 5wyqA-3n6zA:
undetectable		 5wyqA-3n6zA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		5 LEU A  39
GLY A  41
GLY A  44
ILE A 122
GLY A 115
 None
EDO  A 312 ( 4.5A)
None
None
None
 1.02A 5wyqA-3nwoA:
undetectable		 5wyqA-3nwoA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		5 LEU A 211
GLY A 337
ILE A 223
GLY A 213
GLY A 212
 None
None
None
SO4  A 501 (-3.2A)
None
 1.11A 5wyqA-3oz7A:
undetectable		 5wyqA-3oz7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr7 USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 LEU A  92
GLY A  76
GLY A  60
GLY A  90
GLY A  91
 None
 1.07A 5wyqA-3pr7A:
undetectable		 5wyqA-3pr7A:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		7 GLY A 109
GLY A 113
ILE A 133
VAL A 137
LEU A 138
GLY A 140
GLY A 141
 EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
None
EDO  A 243 (-4.0A)
EDO  A 243 (-4.1A)
EDO  A 243 (-3.6A)
 0.50A 5wyqA-3quvA:
21.0		 5wyqA-3quvA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		7 PRO A  85
GLY A 109
GLY A 113
ILE A 133
VAL A 137
LEU A 138
GLY A 141
 EDO  A 243 (-3.7A)
EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
None
EDO  A 243 (-4.0A)
EDO  A 243 (-3.6A)
 0.67A 5wyqA-3quvA:
21.0		 5wyqA-3quvA:
41.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 105
GLY A 143
ILE A 100
GLY A 103
GLY A 102
 None
None
None
DSH  A 303 (-3.5A)
DSH  A 303 ( 4.7A)
 1.09A 5wyqA-3rw9A:
undetectable		 5wyqA-3rw9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 GLY A  10
GLY A  37
ILE A 120
GLY A 101
GLY A 100
 None
 0.89A 5wyqA-3s2uA:
undetectable		 5wyqA-3s2uA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 LEU A  99
GLY A  10
GLY A  37
GLY A 101
GLY A 100
 None
 0.91A 5wyqA-3s2uA:
undetectable		 5wyqA-3s2uA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 5 LEU B  66
PRO B 100
GLN B  99
GLY B  96
GLY B  91
 None
 1.09A 5wyqA-3wlxB:
undetectable		 5wyqA-3wlxB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  13
ILE A 243
VAL A 237
GLY A  17
GLY A  16
 None
 0.90A 5wyqA-3zh2A:
undetectable		 5wyqA-3zh2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		5 PRO A 204
LEU A 118
GLY A 160
GLY A 161
PRO A 110
 None
 0.92A 5wyqA-4ayjA:
undetectable		 5wyqA-4ayjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU C 199
GLY C 130
SER C 212
ILE C 211
VAL C 192
 None
 0.82A 5wyqA-4bujC:
undetectable		 5wyqA-4bujC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 LEU A  42
GLY A 171
LEU A  38
GLY A  11
GLY A  12
 None
FAD  A1392 (-3.5A)
None
FAD  A1392 ( 4.6A)
FAD  A1392 (-3.4A)
 0.94A 5wyqA-4cnkA:
undetectable		 5wyqA-4cnkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dy0 GLIA-DERIVED NEXIN

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 374
SER A 233
ILE A 232
VAL A 370
LEU A 371
 None
 0.74A 5wyqA-4dy0A:
undetectable		 5wyqA-4dy0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecd CHORISMATE SYNTHASE

(Bifidobacterium
longum) 		PF01264
(Chorismate_synt) 		5 PRO A 349
GLY A 220
SER A 352
VAL A 194
GLY A 221
 None
None
None
None
CL  A 402 (-3.5A)
 0.93A 5wyqA-4ecdA:
undetectable		 5wyqA-4ecdA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01583
(APS_kinase) 		5 LEU A 109
GLY A 250
ILE A 181
VAL A 106
GLY A 113
 None
None
ADX  A 301 (-3.9A)
None
SO4  A 302 (-3.2A)
 1.07A 5wyqA-4fxpA:
undetectable		 5wyqA-4fxpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzl BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		5 PRO A 152
ILE A 263
VAL A 126
LEU A 127
GLY A 129
 None
 1.07A 5wyqA-4fzlA:
undetectable		 5wyqA-4fzlA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 153
GLY A 150
VAL A 298
GLY A 284
GLY A 281
 None
 1.00A 5wyqA-4gqaA:
undetectable		 5wyqA-4gqaA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		8 PRO A  93
GLY A 117
SER A 136
VAL A 141
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.22A 5wyqA-4h3zA:
27.8		 5wyqA-4h3zA:
53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR

(Rhodobacter
sphaeroides) 		PF13188
(PAS_8)
PF13426
(PAS_9) 		5 LEU A 338
GLY A 336
SER A 358
VAL A 371
LEU A 370
 None
 1.11A 5wyqA-4hh2A:
undetectable		 5wyqA-4hh2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 GLY A 116
GLY A 146
SER A 133
GLY A 113
GLY A 114
 None
 0.90A 5wyqA-4j2uA:
undetectable		 5wyqA-4j2uA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY C 112
GLY C  68
ILE C 133
VAL C 101
LEU C 100
 None
 1.03A 5wyqA-4jhpC:
undetectable		 5wyqA-4jhpC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY C 198
GLY C 148
SER C 301
GLY C 252
GLY C 251
 None
 1.03A 5wyqA-4jhpC:
undetectable		 5wyqA-4jhpC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 LEU A  13
PRO A   4
GLY A  15
ILE A 321
PRO A 279
 None
 1.09A 5wyqA-4lx4A:
undetectable		 5wyqA-4lx4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 440
GLY A 404
ILE A 522
LEU A 458
GLY A 460
 None
 1.04A 5wyqA-4nenA:
3.3		 5wyqA-4nenA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzl ADENYLATE KINASE

(Francisella
tularensis) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 GLY A 200
ILE A 179
VAL A 107
LEU A   6
GLY A   7
 None
 0.91A 5wyqA-4pzlA:
undetectable		 5wyqA-4pzlA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 GLY A 132
ILE A 351
LEU A 359
GLY A 358
GLY A 357
 None
 0.94A 5wyqA-4qb9A:
undetectable		 5wyqA-4qb9A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 GLY A 236
GLY A 241
ILE A 467
VAL A 255
LEU A 256
 FAD  A 902 (-3.5A)
None
None
None
None
 1.09A 5wyqA-4qi7A:
undetectable		 5wyqA-4qi7A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		5 LEU A  83
ILE A  11
VAL A  45
GLY A  43
GLY A  42
 None
None
LLP  A  46 ( 2.7A)
None
None
 1.09A 5wyqA-4r2vA:
undetectable		 5wyqA-4r2vA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Clostridium
perfringens) 		PF00936
(BMC) 		5 GLY A  98
ILE A  84
VAL A  13
LEU A  38
GLY A  37
 None
 1.05A 5wyqA-4tlhA:
undetectable		 5wyqA-4tlhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 154
PRO A 163
GLY A 152
GLY A 167
ILE A 261
 None
 0.91A 5wyqA-4xiiA:
undetectable		 5wyqA-4xiiA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 320
GLY A 522
ILE A 397
VAL A 325
GLY A 435
 None
 1.04A 5wyqA-4ye5A:
undetectable		 5wyqA-4ye5A:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Haemophilus
influenzae) 		PF01746
(tRNA_m1G_MT) 		12 LEU A  87
PRO A  89
GLN A  90
GLY A 113
GLY A 117
SER A 132
ILE A 133
VAL A 137
LEU A 138
GLY A 140
GLY A 141
PRO A 144
 None
4FD  A 301 ( 3.6A)
None
4FD  A 301 (-4.7A)
4FD  A 301 (-3.6A)
4FD  A 301 (-3.2A)
4FD  A 301 (-4.1A)
4FD  A 301 ( 4.4A)
4FD  A 301 (-3.9A)
4FD  A 301 (-3.6A)
4FD  A 301 (-3.9A)
4FD  A 301 (-4.5A)
 0.28A 5wyqA-4ypwA:
29.1		 5wyqA-4ypwA:
62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 PRO A 544
GLY A 462
ILE A 228
GLY A 536
GLY A 247
 None
None
None
SF4  A 701 ( 4.3A)
SF4  A 701 (-3.6A)
 0.89A 5wyqA-4z3yA:
undetectable		 5wyqA-4z3yA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 PRO A 544
GLY A 462
LEU A 537
GLY A 536
GLY A 247
 None
None
None
SF4  A 701 ( 4.3A)
SF4  A 701 (-3.6A)
 0.98A 5wyqA-4z3yA:
undetectable		 5wyqA-4z3yA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		5 SER A 391
ILE A 393
LEU A 385
GLY A 382
GLY A 381
 SO4  A 709 (-3.9A)
None
None
None
ZN  A 703 ( 4.8A)
 0.90A 5wyqA-5cbmA:
2.3		 5wyqA-5cbmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Pyrobaculum
calidifontis) 		PF13685
(Fe-ADH_2) 		5 GLY A 221
GLY A 109
ILE A 193
VAL A 214
GLY A 219
 None
 0.86A 5wyqA-5fb3A:
undetectable		 5wyqA-5fb3A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 GLY A 179
GLY A 169
ILE A 221
GLY A 182
GLY A 183
 None
None
None
NA  A 403 (-4.6A)
NA  A 403 (-3.9A)
 0.91A 5wyqA-5ffnA:
2.6		 5wyqA-5ffnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 136
GLY A  36
VAL A  64
GLY A 149
GLY A 148
 None
 1.02A 5wyqA-5fp2A:
undetectable		 5wyqA-5fp2A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 GLY b 200
GLY b 349
VAL b 368
LEU b 369
GLY b 371
 None
 1.08A 5wyqA-5gw5b:
undetectable		 5wyqA-5gw5b:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 GLY A 147
GLY A 228
VAL A 163
GLY A 160
GLY A 159
 None
 0.68A 5wyqA-5lh9A:
undetectable		 5wyqA-5lh9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 LEU A 195
GLY A 166
LEU A 137
GLY A 138
GLY A 141
 None
 0.89A 5wyqA-5lunA:
undetectable		 5wyqA-5lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 5 GLY A 434
VAL A 455
LEU A 454
GLY A 450
PRO A 515
 None
None
None
None
SME  A 519 ( 4.7A)
 1.01A 5wyqA-5mhfA:
undetectable		 5wyqA-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		5 LEU A  67
GLY A  65
GLY A 279
LEU A  60
GLY A  61
 None
 1.09A 5wyqA-5mjuA:
undetectable		 5wyqA-5mjuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 GLY A  20
GLY A 145
ILE A  87
GLY A   6
GLY A   5
 None
 1.05A 5wyqA-5mrrA:
undetectable		 5wyqA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 129
GLY A  29
VAL A  57
GLY A 142
GLY A 141
 None
 1.07A 5wyqA-5mzsA:
undetectable		 5wyqA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 5 LEU A 225
GLY A 105
GLY A 103
GLY A 223
GLY A 224
 None
 0.81A 5wyqA-5ndlA:
undetectable		 5wyqA-5ndlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLY A 475
ILE A 504
LEU A 481
GLY A 479
GLY A 480
 None
 1.11A 5wyqA-5t88A:
2.6		 5wyqA-5t88A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usx THIOREDOXIN
REDUCTASE

(Vibrio
vulnificus) 		PF07992
(Pyr_redox_2) 		5 GLY A 217
GLY A 132
VAL A 221
LEU A 212
GLY A 213
 None
 0.96A 5wyqA-5usxA:
undetectable		 5wyqA-5usxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vog PUTATIVE
PHOSPHORIBOSYLTRANSF
ERASE

(Neisseria
gonorrhoeae) 		PF00156
(Pribosyltran) 		5 GLY A  37
VAL A  99
GLY A  39
GLY A  40
PRO A  43
 None
G4P  A 203 (-4.9A)
G4P  A 203 (-3.5A)
None
None
 1.11A 5wyqA-5vogA:
undetectable		 5wyqA-5vogA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 12 LEU A  92
PRO A  94
GLN A  95
GLY A 118
GLY A 122
SER A 137
ILE A 138
VAL A 142
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 ( 4.1A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.22A 5wyqA-5wyrA:
32.6		 5wyqA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 LEU A 292
GLY A 276
GLY A 152
LEU A 290
GLY A 293
 None
FAD  A 501 ( 3.9A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.7A)
None
 0.99A 5wyqA-6brdA:
undetectable		 5wyqA-6brdA:
undetectable