SIMILAR PATTERNS OF AMINO ACIDS FOR 5WWS_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b12 SIGNAL PEPTIDASE I

(Escherichia
coli) 		PF00717
(Peptidase_S24)
PF10502
(Peptidase_S26) 		5 PRO A 241
ASP A 276
ASP A 280
GLY A 272
LEU A 164
 None
 1.13A 5wwsA-1b12A:
undetectable		 5wwsA-1b12A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		5 ALA A  61
PRO A  62
GLY A  64
ASP A  57
LEU A 109
 SAM  A 301 (-4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
None
None
 1.15A 5wwsA-1eizA:
11.0		 5wwsA-1eizA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		7 ALA A  61
PRO A  62
GLY A  64
ASP A  83
ASP A  99
ASP A 124
LEU A 143
 SAM  A 301 (-4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.6A)
 0.74A 5wwsA-1eizA:
11.0		 5wwsA-1eizA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 PRO A 367
GLY A 365
GLY A 378
LEU A 356
LEU A 301
 None
 1.03A 5wwsA-1htqA:
undetectable		 5wwsA-1htqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  87
ASP A 141
GLY A 142
ASP A 158
LEU A 169
 None
 1.07A 5wwsA-1mjfA:
9.4		 5wwsA-1mjfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		5 ALA A 251
PRO A 252
GLY A 153
GLY A 104
LEU A  34
 AKA  A 600 ( 3.8A)
None
None
None
SO4  A3482 (-4.6A)
 1.12A 5wwsA-1q0zA:
undetectable		 5wwsA-1q0zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		5 PRO A 178
GLY A 139
ASP A 311
GLY A 295
ASP A 188
 None
 1.03A 5wwsA-1skaA:
undetectable		 5wwsA-1skaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		9 CYH A 254
ALA A 256
PRO A 257
GLY A 259
ASP A 277
ASP A 303
GLY A 304
ASP A 322
LEU A 352
 None
 0.83A 5wwsA-1sqgA:
31.3		 5wwsA-1sqgA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		5 CYH A 254
GLY A 258
GLY A 304
ASP A 322
LEU A 352
 None
 0.85A 5wwsA-1sqgA:
31.3		 5wwsA-1sqgA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC

(Escherichia
coli) 		PF04127
(DFP) 		6 CYH A 274
ALA A 276
PRO A 197
GLY A 236
GLY A 326
LEU A 392
 None
None
None
None
CTP  A 500 (-3.6A)
None
 1.17A 5wwsA-1u7wA:
3.4		 5wwsA-1u7wA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		5 ALA A 167
PRO A 168
GLY A 147
ASP A 209
ASP A 308
 None
 1.13A 5wwsA-1vblA:
undetectable		 5wwsA-1vblA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 ALA A 222
PRO A 223
GLY A 134
GLY A  26
LEU A 176
 None
None
None
PGO  A 601 ( 3.7A)
None
 0.93A 5wwsA-1womA:
undetectable		 5wwsA-1womA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 ALA A 222
PRO A 223
GLY A 135
GLY A  26
LEU A 176
 None
None
None
PGO  A 601 ( 3.7A)
None
 1.06A 5wwsA-1womA:
undetectable		 5wwsA-1womA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 ALA A 515
PRO A 516
GLY A 217
GLY A 573
LEU A 471
 None
 1.15A 5wwsA-1xf1A:
undetectable		 5wwsA-1xf1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A  51
GLY A 344
GLY A  70
LEU A  42
LEU A  44
 IMP  A 500 (-3.4A)
IMP  A 500 ( 3.7A)
None
None
None
 1.13A 5wwsA-1zfjA:
undetectable		 5wwsA-1zfjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 234
ALA A 236
PRO A 237
ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-4.1A)
SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.40A 5wwsA-2b9eA:
28.8		 5wwsA-2b9eA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwq REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Rattus
norvegicus) 		PF00168
(C2) 		5 PRO A 762
GLY A 760
GLY A 832
LEU A 731
LEU A 852
 None
 1.17A 5wwsA-2bwqA:
undetectable		 5wwsA-2bwqA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 ALA A 127
PRO A 128
ASP A 176
GLY A 177
ASP A 194
 None
 1.05A 5wwsA-2frxA:
31.2		 5wwsA-2frxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 ALA A 127
PRO A 128
GLY A 177
ASP A 194
LEU A 228
 None
 0.60A 5wwsA-2frxA:
31.2		 5wwsA-2frxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7c TOXIN A

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		5 ALA A 180
ASP A 188
GLY A 166
LEU A 202
LEU A 201
 None
 1.02A 5wwsA-2g7cA:
undetectable		 5wwsA-2g7cA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF09455
(Cas_DxTHG) 		5 GLY A 226
LYS A 369
ASP A 368
GLY A 367
LEU A 325
 None
 1.14A 5wwsA-2i71A:
undetectable		 5wwsA-2i71A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 PRO A 357
GLY A 359
LYS A 300
ASP A 255
GLY A 256
 None
 1.17A 5wwsA-2iceA:
undetectable		 5wwsA-2iceA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 CYH A 324
ALA A 322
GLY A 350
ASP A 207
GLY A 224
 None
 1.02A 5wwsA-2ip4A:
2.7		 5wwsA-2ip4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		5 PRO A  98
GLY A 334
GLY A 327
LEU A 118
LEU A 120
 None
 1.11A 5wwsA-2iv0A:
undetectable		 5wwsA-2iv0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		6 ALA A  32
PRO A  33
ASP A  62
ASP A  79
ASP A 104
LEU A 123
 SAM  A 201 (-3.8A)
SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
None
 0.78A 5wwsA-2nyuA:
10.6		 5wwsA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 ALA A  32
PRO A  33
ASP A  62
ASP A  79
LEU A 123
 SAM  A 201 (-3.8A)
SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
None
 0.58A 5wwsA-2nyuA:
10.6		 5wwsA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 ALA A  32
PRO A  33
ASP A  79
ASP A  28
LEU A 123
 SAM  A 201 (-3.8A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.3A)
SAM  A 201 ( 4.8A)
None
 1.15A 5wwsA-2nyuA:
10.6		 5wwsA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 ALA A 568
GLY A 507
ASP A 635
LEU A 667
LEU A 674
 None
 1.15A 5wwsA-2olsA:
undetectable		 5wwsA-2olsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		5 ALA A 390
GLY A 149
GLY A 330
LEU A 380
LEU A 329
 None
ADP  A1002 (-3.2A)
None
None
None
 1.11A 5wwsA-2owmA:
undetectable		 5wwsA-2owmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ALA A  56
GLY A 111
GLY A  63
LEU A 324
LEU A 318
 None
 1.13A 5wwsA-2xn6A:
undetectable		 5wwsA-2xn6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ALA A 212
ASP A 158
GLY A 156
LEU A 289
LEU A 155
 None
 1.11A 5wwsA-2ymvA:
undetectable		 5wwsA-2ymvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 ALA A 269
PRO A 270
ASP A 291
ASP A 318
LEU A 367
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
None
 0.93A 5wwsA-2yxlA:
32.2		 5wwsA-2yxlA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		8 ALA A 269
PRO A 270
GLY A 272
ASP A 291
ASP A 318
ASP A 337
LEU A 367
LEU A 371
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
None
None
 0.31A 5wwsA-2yxlA:
32.2		 5wwsA-2yxlA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  89
ASP A 144
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.97A 5wwsA-2zsuA:
9.8		 5wwsA-2zsuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 ALA A  93
PRO A  94
ASP A 142
ASP A  89
LEU A 193
 SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 ( 4.4A)
None
 1.08A 5wwsA-3a4tA:
29.5		 5wwsA-3a4tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		7 CYH A  91
ALA A  93
PRO A  94
GLY A  96
ASP A 142
ASP A 163
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
None
 0.50A 5wwsA-3a4tA:
29.5		 5wwsA-3a4tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 GLY A 111
GLY A 102
ASP A 116
LEU A 239
LEU A 235
 None
 1.05A 5wwsA-3bsfA:
undetectable		 5wwsA-3bsfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		5 ALA A  44
GLY A  71
GLY A 236
LEU A 197
LEU A 239
 None
None
None
None
ADP  A 411 (-4.4A)
 1.03A 5wwsA-3c4nA:
2.5		 5wwsA-3c4nA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE

(Bdellovibrio
bacteriovorus) 		no annotation 5 ALA A 230
GLY A  28
ASP A  53
LEU A  60
LEU A  56
 None
 1.07A 5wwsA-3cawA:
undetectable		 5wwsA-3cawA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		5 ALA A 303
PRO A 304
GLY A 285
LEU A 256
LEU A 246
 None
 1.15A 5wwsA-3d0qA:
3.6		 5wwsA-3d0qA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 PRO A  49
GLY A  51
ASP A  67
ASP A  83
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.2A)
SAM  A   1 (-2.7A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.7A)
 0.64A 5wwsA-3douA:
10.0		 5wwsA-3douA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ALA A 187
GLY A 191
ASP A 182
LEU A 382
LEU A 369
 None
 1.15A 5wwsA-3eh2A:
undetectable		 5wwsA-3eh2A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN

(Ralstonia
solanacearum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 121
PRO A 120
GLY A 311
GLY A 188
LEU A 172
 None
 1.10A 5wwsA-3gg9A:
5.4		 5wwsA-3gg9A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 GLY A  18
ASP A 415
GLY A 416
ASP A  33
LEU A 329
 None
 1.07A 5wwsA-3i4jA:
undetectable		 5wwsA-3i4jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igs N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE 2

(Salmonella
enterica) 		PF04131
(NanE) 		5 ALA A 103
ASP A 138
GLY A 139
LEU A 170
LEU A 174
 None
SO4  A 232 ( 4.9A)
None
None
None
 1.11A 5wwsA-3igsA:
undetectable		 5wwsA-3igsA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		5 GLY A 118
ASP A 390
GLY A 169
LEU A 465
LEU A  79
 None
 0.91A 5wwsA-3khzA:
undetectable		 5wwsA-3khzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 CYH A 113
ALA A 115
PRO A 116
GLY A 118
ASP A 182
 None
 0.47A 5wwsA-3m4xA:
32.5		 5wwsA-3m4xA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6q PEPTIDE DEFORMYLASE
1B

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		5 PRO A  47
GLY A  50
ASP A   8
LEU A 159
LEU A 162
 None
 1.06A 5wwsA-3m6qA:
undetectable		 5wwsA-3m6qA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 ALA A 111
PRO A 112
GLY A 114
ASP A 177
LEU A 211
 None
 0.43A 5wwsA-3m6xA:
33.7		 5wwsA-3m6xA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m97 CYTOCHROME C-552

(Paracoccus
denitrificans) 		PF00034
(Cytochrom_C) 		5 CYH X  54
ALA X  56
GLY X  65
LEU X 123
LEU X 132
 HEC  X 141 (-1.8A)
None
None
HEC  X 141 ( 4.8A)
HEC  X 141 (-4.8A)
 1.17A 5wwsA-3m97X:
undetectable		 5wwsA-3m97X:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyw PUTATIVE
OXIDOREDUCTASE

(Bacteroides
thetaiotaomicron) 		PF00106
(adh_short) 		5 ALA A  93
GLY A  18
GLY A 121
LEU A 166
LEU A 123
 None
 1.16A 5wwsA-3nywA:
7.6		 5wwsA-3nywA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2y ALANINE
DEHYDROGENASE/PYRIDI
NE NUCLEOTIDE
TRANSHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A  84
ASP A 331
ASP A  65
LEU A  27
LEU A  32
 None
None
CA  A 361 ( 4.1A)
None
None
 1.14A 5wwsA-3p2yA:
4.8		 5wwsA-3p2yA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr5 CARDIAC CA2+ RELEASE
CHANNEL

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		5 ALA A 206
ASP A 204
GLY A 148
LEU A  37
LEU A 130
 None
 1.17A 5wwsA-3qr5A:
undetectable		 5wwsA-3qr5A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 CYH A  65
ALA A 110
GLY A 131
LEU A  39
LEU A  22
 None
 1.17A 5wwsA-3r9qA:
undetectable		 5wwsA-3r9qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 106
ASP A 155
GLY A 156
ASP A 173
LEU A 184
 None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 1.04A 5wwsA-3rw9A:
9.6		 5wwsA-3rw9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		5 CYH A  37
ALA A  16
ASP A  38
ASP A  76
LEU A  83
 None
NAD  A 279 ( 4.0A)
NAD  A 279 (-2.9A)
NAD  A 279 (-3.6A)
None
 1.11A 5wwsA-3s55A:
7.2		 5wwsA-3s55A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13306
(LRR_5) 		5 ALA A 307
GLY A 285
LYS A 328
ASP A 327
GLY A 326
 None
 1.12A 5wwsA-3sb4A:
undetectable		 5wwsA-3sb4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A  49
GLY A 342
GLY A  68
LEU A  40
LEU A  42
 XMP  A 500 (-3.5A)
XMP  A 500 (-3.3A)
None
None
None
 1.13A 5wwsA-3tsdA:
undetectable		 5wwsA-3tsdA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		5 PRO A 243
ASP A 146
GLY A 196
ASP A 248
LEU A 209
 None
 1.08A 5wwsA-3v1zA:
undetectable		 5wwsA-3v1zA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ALA A 693
GLY A 743
ASP A 697
ASP A 680
LEU A 668
 None
 1.16A 5wwsA-3w5nA:
undetectable		 5wwsA-3w5nA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtg HEMOGLOBIN SUBUNIT
ALPHA-A

(Dromaius
novaehollandiae) 		PF00042
(Globin) 		5 ALA A 110
PRO A 114
GLY A 102
LEU A  66
LEU A 129
 None
None
None
HEM  A 201 (-4.8A)
None
 1.16A 5wwsA-3wtgA:
undetectable		 5wwsA-3wtgA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apm APICAL MEMBRANE
ANTIGEN 1

(Babesia
divergens) 		PF02430
(AMA-1) 		5 PRO A 438
LYS A 310
ASP A 311
GLY A 428
ASP A 335
 None
None
None
None
GOL  A1517 (-2.4A)
 1.08A 5wwsA-4apmA:
undetectable		 5wwsA-4apmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		5 ALA A 195
PRO A 209
GLY A 275
LEU A 250
LEU A 252
 None
 0.97A 5wwsA-4dimA:
3.6		 5wwsA-4dimA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		10 CYH A 181
ALA A 183
PRO A 185
GLY A 186
ASP A 204
ASP A 237
GLY A 238
ASP A 255
LEU A 287
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
None
None
 0.46A 5wwsA-4fzvA:
26.9		 5wwsA-4fzvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 CYH A 181
GLY A 185
ASP A 255
LEU A 287
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.7A)
None
None
 0.91A 5wwsA-4fzvA:
26.9		 5wwsA-4fzvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 ALA A  35
GLY A   8
ASP A 264
GLY A 305
LEU A  91
 GOL  A 401 (-3.9A)
None
None
None
None
 1.01A 5wwsA-4gm6A:
3.2		 5wwsA-4gm6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi0 UREASE ACCESSORY
PROTEIN UREG

(Helicobacter
pylori) 		PF02492
(cobW) 		5 ALA E 123
GLY E 154
ASP E 121
ASP E 126
LEU E 104
 None
 1.08A 5wwsA-4hi0E:
undetectable		 5wwsA-4hi0E:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PRO A 216
GLY A 178
GLY A 260
ASP A 241
LEU A 263
 None
 1.13A 5wwsA-4j3zA:
undetectable		 5wwsA-4j3zA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE

(Francisella
philomiragia) 		PF01048
(PNP_UDP_1) 		5 ALA A  91
GLY A 143
ASP A 219
LEU A 136
LEU A 138
 None
 1.13A 5wwsA-4josA:
undetectable		 5wwsA-4josA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		5 ALA A 394
GLY A 397
GLY A 157
LEU A 142
LEU A 144
 None
 1.16A 5wwsA-4ke4A:
undetectable		 5wwsA-4ke4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PRO A 327
GLY A 350
GLY A 318
LEU A 338
LEU A 341
 None
 1.02A 5wwsA-4mn8A:
undetectable		 5wwsA-4mn8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		6 CYH A 277
PRO A 280
GLY A 282
ASP A 335
ASP A 364
LEU A 383
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
 1.03A 5wwsA-4n49A:
8.5		 5wwsA-4n49A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 GLY A 295
GLY A 233
ASP A 345
LEU A 275
LEU A 277
 None
 0.99A 5wwsA-4o5pA:
undetectable		 5wwsA-4o5pA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 ALA A 156
PRO A 155
GLY A 191
GLY A 117
ASP A 162
 None
 0.94A 5wwsA-4pdxA:
undetectable		 5wwsA-4pdxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 ALA D 106
PRO D 105
GLY D 289
GLY D 165
LEU D 149
 None
 1.07A 5wwsA-4s1vD:
5.4		 5wwsA-4s1vD:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		5 GLY A1342
GLY A1361
ASP A1353
LEU A1454
LEU A1450
 None
 1.01A 5wwsA-4w4tA:
5.8		 5wwsA-4w4tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 ALA A 189
PRO A 190
GLY A 213
LEU A 134
LEU A 146
 None
 1.12A 5wwsA-4x2rA:
undetectable		 5wwsA-4x2rA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Mycobacterium
tuberculosis) 		PF01180
(DHO_dh) 		5 ALA A  66
GLY A 313
GLY A  72
LEU A 131
LEU A  75
 FMN  A 401 (-3.6A)
FMN  A 401 (-3.3A)
None
None
None
 1.11A 5wwsA-4xq6A:
undetectable		 5wwsA-4xq6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		5 GLY A 323
ASP A 283
GLY A 239
LEU A 313
LEU A 216
 FAD  A 700 (-3.1A)
None
None
None
None
 0.96A 5wwsA-4xvgA:
undetectable		 5wwsA-4xvgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		5 ALA A  60
GLY A  99
ASP A  44
GLY A  42
LEU A 203
 None
 1.15A 5wwsA-4y7dA:
undetectable		 5wwsA-4y7dA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 5 PRO A  49
GLY A  82
GLY A 118
LEU A 110
LEU A 117
 None
 1.12A 5wwsA-5awpA:
undetectable		 5wwsA-5awpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 ALA A  83
GLY A  49
ASP A 323
GLY A 324
ASP A 100
 None
 1.09A 5wwsA-5cfaA:
undetectable		 5wwsA-5cfaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 GLY A 192
ASP A 208
ASP A 235
ASP A 254
LEU A 271
 SAM  A 400 (-3.7A)
SAM  A 400 (-2.8A)
SAM  A 400 (-3.4A)
None
None
 1.09A 5wwsA-5e72A:
14.3		 5wwsA-5e72A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 ALA A 145
PRO A 146
GLY A 291
GLY A 358
LEU A 361
 None
None
MPG  A 625 ( 3.7A)
None
None
 1.09A 5wwsA-5f15A:
undetectable		 5wwsA-5f15A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcs DIABODY
DIABODY

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 ALA H 222
GLY L  90
ASP H 218
GLY H 151
LEU H 122
 None
 1.14A 5wwsA-5fcsH:
undetectable		 5wwsA-5fcsH:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ALA A 385
GLY A 389
ASP A 382
GLY A 464
LEU A 454
 None
 1.09A 5wwsA-5k3hA:
undetectable		 5wwsA-5k3hA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		5 ALA A  23
GLY A 248
GLY A  43
LEU A  14
LEU A  16
 FMN  A 401 (-3.3A)
FMN  A 401 (-3.6A)
None
None
None
 1.15A 5wwsA-5kswA:
undetectable		 5wwsA-5kswA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ALA A  33
GLY A  82
ASP A  31
GLY A  29
LEU A  47
 None
 1.11A 5wwsA-5mjsA:
2.4		 5wwsA-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		5 ALA A 120
GLY A 125
GLY A 108
LEU A  65
LEU A  37
 None
 1.14A 5wwsA-5swnA:
undetectable		 5wwsA-5swnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 ALA A 321
PRO A 322
GLY A 407
LEU A 374
LEU A 406
 None
 1.14A 5wwsA-5u2gA:
undetectable		 5wwsA-5u2gA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ALA A 380
GLY A 385
GLY A 243
LEU A 409
LEU A  12
 None
 1.13A 5wwsA-5ujsA:
undetectable		 5wwsA-5ujsA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 ALA A  49
GLY A 342
GLY A  68
LEU A  40
LEU A  42
 IMP  A 500 (-3.4A)
IMP  A 500 ( 3.7A)
None
None
None
 1.08A 5wwsA-5upyA:
undetectable		 5wwsA-5upyA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 ALA A  49
GLY A 342
GLY A  68
LEU A  40
LEU A  42
 IMP  A 501 (-3.2A)
IMP  A 501 (-3.1A)
None
None
None
 1.02A 5wwsA-5uuwA:
undetectable		 5wwsA-5uuwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ALA B 516
GLY B 520
ASP B 511
LEU B 702
LEU B 689
 None
 1.01A 5wwsA-5vniB:
undetectable		 5wwsA-5vniB:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 ALA A 244
PRO A 245
ASP A 266
LYS A 271
ASP A 293
LEU A 350
 None
C  C  72 ( 4.7A)
None
C  C  70 ( 3.9A)
None
G  C   3 ( 3.9A)
 1.12A 5wwsA-5wwtA:
65.1		 5wwsA-5wwtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		12 CYH A 242
ALA A 244
PRO A 245
GLY A 247
ASP A 266
LYS A 267
LYS A 271
ASP A 293
GLY A 294
ASP A 323
LEU A 350
LEU A 354
 None
None
C  C  72 ( 4.7A)
None
None
G  C   3 ( 3.5A)
C  C  70 ( 3.9A)
None
None
C  C  72 ( 2.8A)
G  C   3 ( 3.9A)
None
 0.16A 5wwsA-5wwtA:
65.1		 5wwsA-5wwtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		5 ALA A  51
GLY A  43
GLY A  94
LEU A  16
LEU A  12
 None
 1.13A 5wwsA-5xoyA:
undetectable		 5wwsA-5xoyA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzn -

(-) 		no annotation 5 ALA U  53
PRO U  54
ASP U  60
LEU U  67
LEU U  75
 DMS  U 202 ( 3.5A)
HTG  U 203 (-3.9A)
HTG  U 203 (-4.3A)
None
None
 1.04A 5wwsA-5zznU:
undetectable		 5wwsA-5zznU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		5 CYH A 606
ALA A 670
PRO A 671
ASP A 603
LEU A 648
 None
 1.16A 5wwsA-6axeA:
undetectable		 5wwsA-6axeA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 5 ALA A 223
GLY A 228
GLY A 288
LEU A 382
LEU A 289
 None
 1.08A 5wwsA-6cxdA:
undetectable		 5wwsA-6cxdA:
undetectable