SIMILAR PATTERNS OF AMINO ACIDS FOR 5WP1_A_BEZA403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bco BACTERIOPHAGE MU
TRANSPOSASE

(Escherichia
virus Mu) 		PF02914
(DDE_2)
PF09299
(Mu-transpos_C) 		4 GLY A 282
PHE A 280
ASN A 281
LYS A 512
 None
 1.30A 5wp1A-1bcoA:
0.0		 5wp1A-1bcoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		4 GLY B  45
PHE B  44
ASN B  56
LYS B  58
 None
 1.14A 5wp1A-1hdsB:
undetectable		 5wp1A-1hdsB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmq HYPOTHETICAL PROTEIN
EF0006

(Enterococcus
faecalis) 		PF09627
(PrgU) 		4 GLY A 113
PHE A 112
ASN A  69
LYS A  71
 None
 1.08A 5wp1A-2gmqA:
0.1		 5wp1A-2gmqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 530
PHE C 451
ASN C 529
LYS C 449
 None
 1.46A 5wp1A-3j9uC:
0.0		 5wp1A-3j9uC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 150
PHE A 149
ASN A  22
LYS A 157
 None
 0.96A 5wp1A-3pv2A:
0.2		 5wp1A-3pv2A:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 199
PHE A 200
ASN A 274
LYS A 276
 None
None
CL  A 416 (-3.7A)
None
 0.79A 5wp1A-4qtbA:
37.9		 5wp1A-4qtbA:
82.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jif HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 GLY A 114
PHE A 115
ASN A 123
LYS A 116
 None
 1.29A 5wp1A-5jifA:
0.0		 5wp1A-5jifA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 GLY A 350
PHE A 348
ASN A 349
LYS A 397
 CA  A 504 ( 4.7A)
None
None
None
 1.50A 5wp1A-5k8rA:
0.0		 5wp1A-5k8rA:
23.85