SIMILAR PATTERNS OF AMINO ACIDS FOR 5WM2_A_ACTA605

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		3 THR A 356
THR A 355
ARG A 328
 None
 0.89A 5wm2A-1d5tA:
undetectable		 5wm2A-1d5tA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 THR A 132
THR A 144
ARG A  18
 None
 0.95A 5wm2A-1dgsA:
undetectable		 5wm2A-1dgsA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 THR A 142
THR A 120
ARG A 341
 None
 0.81A 5wm2A-1e8cA:
2.3		 5wm2A-1e8cA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 THR A 462
THR A 476
ARG A 489
 None
 1.03A 5wm2A-1ggmA:
undetectable		 5wm2A-1ggmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		3 THR A 709
THR A 556
ARG A 678
 None
 0.86A 5wm2A-1gm5A:
undetectable		 5wm2A-1gm5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 THR A 393
THR A 471
ARG A 484
 None
 0.50A 5wm2A-1gytA:
undetectable		 5wm2A-1gytA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 THR O 207
THR O 206
ARG O 195
 None
None
SO4  O 338 (-3.8A)
 0.99A 5wm2A-1hdgO:
2.0		 5wm2A-1hdgO:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		3 THR A 216
THR A 235
ARG A 244
 CFX  A1300 (-3.2A)
CFX  A1300 (-3.6A)
CFX  A1300 (-3.5A)
 0.99A 5wm2A-1i2wA:
undetectable		 5wm2A-1i2wA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		3 THR A 391
THR A 266
ARG A 270
 None
 1.04A 5wm2A-1morA:
2.2		 5wm2A-1morA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 THR A1314
THR A 510
ARG A1306
 None
 1.04A 5wm2A-1n5xA:
undetectable		 5wm2A-1n5xA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 THR A 275
THR A 154
ARG A  77
 None
 0.77A 5wm2A-1q33A:
undetectable		 5wm2A-1q33A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 THR A 557
THR A 558
ARG A 559
 None
 1.07A 5wm2A-1r5nA:
undetectable		 5wm2A-1r5nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		3 THR A 554
THR A 203
ARG A 218
 None
NAD  A1002 ( 4.4A)
None
 1.01A 5wm2A-1vrqA:
undetectable		 5wm2A-1vrqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 THR A 162
THR A 190
ARG A 202
 None
 0.59A 5wm2A-1w8oA:
undetectable		 5wm2A-1w8oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		3 THR A 252
THR A 254
ARG A 260
 None
 1.07A 5wm2A-1z3zA:
3.2		 5wm2A-1z3zA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  30
THR H  73
ARG H  71
 None
 1.06A 5wm2A-1zanH:
undetectable		 5wm2A-1zanH:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		3 THR A 320
THR A 323
ARG A 331
 None
 0.98A 5wm2A-2a0uA:
3.1		 5wm2A-2a0uA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 THR A 213
THR A 225
ARG A 216
 None
 0.88A 5wm2A-2c11A:
undetectable		 5wm2A-2c11A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		3 THR A 555
THR A 204
ARG A 219
 None
NAD  A 999 (-4.2A)
None
 0.98A 5wm2A-2gahA:
undetectable		 5wm2A-2gahA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 THR A  55
THR A 575
ARG A 526
 None
 1.05A 5wm2A-2gskA:
undetectable		 5wm2A-2gskA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 THR A 453
THR A 457
ARG A 460
 None
 1.04A 5wm2A-2h8hA:
undetectable		 5wm2A-2h8hA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 THR A  54
THR A 475
ARG A 478
 None
 1.04A 5wm2A-2ihtA:
3.1		 5wm2A-2ihtA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k70 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1943

(Thermus
thermophilus) 		PF04314
(PCuAC) 		3 THR A   4
THR A  21
ARG A  74
 None
 0.64A 5wm2A-2k70A:
undetectable		 5wm2A-2k70A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		3 THR A 152
THR A 209
ARG A 213
 None
 0.74A 5wm2A-2p4zA:
undetectable		 5wm2A-2p4zA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		3 THR A 318
THR A 369
ARG A 363
 None
 1.02A 5wm2A-2qbyA:
undetectable		 5wm2A-2qbyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 THR A 180
THR A 158
ARG A 377
 UAG  A1498 ( 4.6A)
None
None
 1.01A 5wm2A-2wtzA:
2.2		 5wm2A-2wtzA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		3 THR A 277
THR A 119
ARG A 122
 None
 0.88A 5wm2A-2xikA:
undetectable		 5wm2A-2xikA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01128
(IspD) 		3 THR A 187
THR A 115
ARG A 118
 None
 1.04A 5wm2A-2ycmA:
undetectable		 5wm2A-2ycmA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 THR A 212
THR A 211
ARG A 200
 None
None
SO4  A1340 (-3.8A)
 0.97A 5wm2A-3b20A:
2.1		 5wm2A-3b20A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 THR A 147
THR A 190
ARG A 193
 None
 1.02A 5wm2A-3e97A:
undetectable		 5wm2A-3e97A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faj PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
two-tailed
virus) 		no annotation 3 THR A  51
THR A 107
ARG A 110
 CL  A 132 (-4.0A)
None
CL  A 132 (-4.0A)
 1.04A 5wm2A-3fajA:
undetectable		 5wm2A-3fajA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		3 THR A 294
THR A 293
ARG A 318
 None
 0.98A 5wm2A-3gd9A:
undetectable		 5wm2A-3gd9A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 THR A 390
THR A 468
ARG A 482
 None
 0.46A 5wm2A-3h8fA:
undetectable		 5wm2A-3h8fA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		3 THR A  55
THR A 234
ARG A 189
 None
 0.97A 5wm2A-3isrA:
undetectable		 5wm2A-3isrA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 3 THR D 233
THR D 268
ARG D 265
 None
 1.04A 5wm2A-3jazD:
undetectable		 5wm2A-3jazD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5r CADHERIN 13

(Mus musculus) 		PF00028
(Cadherin) 		3 THR A  86
THR A  80
ARG A  36
 None
 1.07A 5wm2A-3k5rA:
undetectable		 5wm2A-3k5rA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6f T-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 THR A  86
THR A  80
ARG A  36
 None
 1.06A 5wm2A-3k6fA:
undetectable		 5wm2A-3k6fA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 THR A 161
THR A  14
ARG A  18
 None
 0.92A 5wm2A-3l7gA:
undetectable		 5wm2A-3l7gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9l HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
protegens) 		PF13419
(HAD_2) 		3 THR A 181
THR A 167
ARG A 161
 None
 1.07A 5wm2A-3m9lA:
2.1		 5wm2A-3m9lA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 3 THR A  32
THR A  74
ARG A  77
 None
 1.04A 5wm2A-3n6zA:
undetectable		 5wm2A-3n6zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		3 THR A1709
THR A1625
ARG A1590
 None
 0.82A 5wm2A-3pg7A:
undetectable		 5wm2A-3pg7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		3 THR A 298
THR A 284
ARG A 288
 None
 1.00A 5wm2A-3qatA:
undetectable		 5wm2A-3qatA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tow MULTIVESICULAR BODY
SUBUNIT 12B

(Homo sapiens) 		PF10240
(DUF2464) 		3 THR A 136
THR A 133
ARG A  92
 None
 0.97A 5wm2A-3towA:
undetectable		 5wm2A-3towA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		3 THR A 118
THR A 248
ARG A  30
 None
 1.08A 5wm2A-3wafA:
undetectable		 5wm2A-3wafA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		3 THR A 154
THR A 124
ARG A 122
 SAH  A 701 (-3.4A)
SAH  A 701 ( 4.9A)
SAH  A 701 (-4.0A)
 1.07A 5wm2A-3wstA:
2.2		 5wm2A-3wstA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 3 THR A  70
THR A  64
ARG A  97
 None
 0.79A 5wm2A-3wweA:
1.9		 5wm2A-3wweA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		3 THR A 391
THR A 394
ARG A 272
 None
 0.94A 5wm2A-3zyoA:
undetectable		 5wm2A-3zyoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		3 THR A 234
THR A 187
ARG A 104
 None
 0.91A 5wm2A-4a3uA:
2.3		 5wm2A-4a3uA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 THR A 137
THR A 115
ARG A 335
 MG  A 503 (-3.3A)
MG  A 503 ( 3.7A)
PO4  A 601 (-3.9A)
 0.67A 5wm2A-4c13A:
undetectable		 5wm2A-4c13A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		3 THR B 328
THR A 348
ARG A 327
 None
 0.81A 5wm2A-4cakB:
undetectable		 5wm2A-4cakB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 THR A  61
THR A 152
ARG A 155
 None
 1.01A 5wm2A-4dfeA:
undetectable		 5wm2A-4dfeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 THR A 208
THR A 207
ARG A 196
 None
 0.98A 5wm2A-4dibA:
2.1		 5wm2A-4dibA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebj AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF01909
(NTP_transf_2) 		3 THR A 197
THR A 210
ARG A 205
 None
 1.05A 5wm2A-4ebjA:
2.3		 5wm2A-4ebjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 THR A  20
THR A  64
ARG A  52
 None
 0.98A 5wm2A-4ewjA:
undetectable		 5wm2A-4ewjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj4 UNCHARACTERIZED
PROTEIN

(Halobacterium
salinarum) 		PF07920
(DUF1684) 		3 THR A 122
THR A 127
ARG A 132
 None
 1.01A 5wm2A-4fj4A:
undetectable		 5wm2A-4fj4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		3 THR A 439
THR A 436
ARG A 432
 None
 0.62A 5wm2A-4fnmA:
1.9		 5wm2A-4fnmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftf ALTERNATE SECRETIN
PATHWAY SUBUNIT S
(VC395_1821, VC1703)

(Vibrio cholerae) 		PF16549
(T2SSS_2) 		3 THR A  54
THR A  96
ARG A  97
 None
 0.92A 5wm2A-4ftfA:
undetectable		 5wm2A-4ftfA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		3 THR C 223
THR C  85
ARG C  50
 None
 1.04A 5wm2A-4ifdC:
undetectable		 5wm2A-4ifdC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		3 THR A 162
THR A 190
ARG A 202
 None
 0.89A 5wm2A-4j9tA:
undetectable		 5wm2A-4j9tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		3 THR A 588
THR A 626
ARG A 707
 None
 0.87A 5wm2A-4k3bA:
undetectable		 5wm2A-4k3bA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 THR A 363
THR A 304
ARG A 598
 None
 1.04A 5wm2A-4k6mA:
undetectable		 5wm2A-4k6mA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		3 THR A 114
THR A 141
ARG A 359
 None
 1.04A 5wm2A-4kv7A:
2.7		 5wm2A-4kv7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C

(Butyrivibrio
proteoclasticus) 		PF00150
(Cellulase) 		3 THR A  35
THR A 237
ARG A 267
 None
 1.00A 5wm2A-4nf7A:
2.0		 5wm2A-4nf7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 THR A 139
THR A  83
ARG A  86
 None
 1.05A 5wm2A-4o5hA:
2.5		 5wm2A-4o5hA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A

(Burkholderia
cenocepacia) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 THR A   8
THR A 195
ARG A  17
 None
 0.76A 5wm2A-4qq7A:
undetectable		 5wm2A-4qq7A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 THR A 163
THR A  14
ARG A  18
 None
 0.85A 5wm2A-4qr8A:
undetectable		 5wm2A-4qr8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		3 THR A 140
THR A 144
ARG A 123
 None
 1.07A 5wm2A-4rk0A:
undetectable		 5wm2A-4rk0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
HEMOPEXIN

(Haemophilus
influenzae;
Oryctolagus
cuniculus) 		PF05860
(Haemagg_act)
PF00045
(Hemopexin) 		3 THR B 151
THR B 153
ARG A 516
 None
 0.99A 5wm2A-4rt6B:
undetectable		 5wm2A-4rt6B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toq CLASS III CHITINASE

(Punica granatum) 		PF00704
(Glyco_hydro_18) 		3 THR A  19
THR A  22
ARG A  24
 None
 1.08A 5wm2A-4toqA:
undetectable		 5wm2A-4toqA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		3 THR A 344
THR A 371
ARG A 347
 None
 0.95A 5wm2A-4uq9A:
undetectable		 5wm2A-4uq9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		3 THR A  78
THR A  81
ARG A  60
 None
 1.04A 5wm2A-4usqA:
undetectable		 5wm2A-4usqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG

(Paracoccus
denitrificans) 		PF03150
(CCP_MauG) 		3 THR A 275
THR A  42
ARG A  39
 None
 0.94A 5wm2A-4y5rA:
undetectable		 5wm2A-4y5rA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yii ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
UBIQUITIN-CONJUGATIN
G ENZYME E2 C

(Homo sapiens;
Homo sapiens) 		PF08672
(ANAPC2)
PF00179
(UQ_con) 		3 THR A 763
THR U  65
ARG U  78
 None
 1.06A 5wm2A-4yiiA:
undetectable		 5wm2A-4yiiA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 THR A1313
THR A 509
ARG A1305
 None
 1.01A 5wm2A-4yswA:
undetectable		 5wm2A-4yswA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 THR A 161
THR A  14
ARG A  18
 None
 0.93A 5wm2A-4zwoA:
undetectable		 5wm2A-4zwoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		3 THR A 543
THR A 542
ARG A 409
 None
 1.00A 5wm2A-5b2dA:
undetectable		 5wm2A-5b2dA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 THR A 205
THR A 254
ARG A 279
 None
 1.04A 5wm2A-5e7qA:
36.7		 5wm2A-5e7qA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 THR A 205
THR A 254
ARG A 281
 None
 0.71A 5wm2A-5e7qA:
36.7		 5wm2A-5e7qA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 THR A1320
THR A 517
ARG A1312
 None
 0.86A 5wm2A-5epgA:
undetectable		 5wm2A-5epgA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7o METHYLTHIOADENOSINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		3 THR A 181
THR A 111
ARG A 114
 None
 1.02A 5wm2A-5f7oA:
2.1		 5wm2A-5f7oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		3 THR A 617
THR A 592
ARG A 589
 None
 1.04A 5wm2A-5f7uA:
2.3		 5wm2A-5f7uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		3 THR A 211
THR A 230
ARG A 238
 IM2  A 301 (-4.1A)
IM2  A 301 (-3.6A)
IM2  A 301 (-3.5A)
 1.00A 5wm2A-5f83A:
undetectable		 5wm2A-5f83A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 THR A 402
THR A 396
ARG A 326
 None
 1.06A 5wm2A-5fokA:
undetectable		 5wm2A-5fokA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 THR A  40
THR A 198
ARG A 199
 None
 1.05A 5wm2A-5i1wA:
undetectable		 5wm2A-5i1wA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 THR A 774
THR A 302
ARG A 306
 None
 1.06A 5wm2A-5im3A:
2.2		 5wm2A-5im3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 THR A 360
THR A 301
ARG A 594
 None
 1.02A 5wm2A-5iq6A:
2.7		 5wm2A-5iq6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 THR A 360
THR A 301
ARG A 594
 None
 0.98A 5wm2A-5jjrA:
undetectable		 5wm2A-5jjrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 THR A 681
THR A 686
ARG A 677
 THR  A 681 ( 0.8A)
THR  A 686 ( 0.8A)
ARG  A 677 ( 0.6A)
 1.03A 5wm2A-5l5nA:
undetectable		 5wm2A-5l5nA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5

(Schizosaccharomyces
pombe) 		no annotation 3 THR A 484
THR A 487
ARG A 514
 None
 1.08A 5wm2A-5mg8A:
undetectable		 5wm2A-5mg8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17) 		3 THR W 504
THR W 500
ARG W 477
 None
 0.90A 5wm2A-5n9jW:
undetectable		 5wm2A-5n9jW:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		3 THR A 242
THR A 247
ARG A 248
 None
 1.05A 5wm2A-5nyyA:
undetectable		 5wm2A-5nyyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN

(Zea mays) 		PF07714
(Pkinase_Tyr) 		3 THR A 842
THR A 846
ARG A 854
 None
 1.03A 5wm2A-5uv4A:
undetectable		 5wm2A-5uv4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5w MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		3 THR A 192
THR A 196
ARG A 156
 None
 0.78A 5wm2A-5v5wA:
undetectable		 5wm2A-5v5wA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4m TRANSCRIPTIONAL
REGULATOR

(Streptococcus
dysgalactiae) 		no annotation 3 THR A  65
THR A   8
ARG A  11
 None
 1.04A 5wm2A-5w4mA:
undetectable		 5wm2A-5w4mA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 3 THR A 245
THR A 295
ARG A 322
 ACT  A 604 (-3.0A)
ACT  A 604 (-3.6A)
ACT  A 604 (-3.9A)
 0.09A 5wm2A-5wm4A:
71.8		 5wm2A-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 3 THR A 391
THR A 318
ARG A 330
 None
 0.90A 5wm2A-5x7nA:
2.1		 5wm2A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		3 THR A 349
THR A 217
ARG A 402
 None
None
FLC  A 501 (-3.7A)
 1.04A 5wm2A-5x9rA:
undetectable		 5wm2A-5x9rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus) 		no annotation 3 THR A 370
THR A 373
ARG A 377
 None
 1.06A 5wm2A-5xflA:
undetectable		 5wm2A-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S12E

(Leishmania
donovani) 		no annotation 3 THR Q  53
THR Q  58
ARG Q 124
 None
 1.04A 5wm2A-6az1Q:
undetectable		 5wm2A-6az1Q:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 3 THR A 252
THR A 441
ARG A 449
 ATP  A 601 (-4.4A)
ATP  A 601 ( 4.1A)
ATP  A 601 (-3.1A)
 0.88A 5wm2A-6d5iA:
undetectable		 5wm2A-6d5iA:
undetectable