SIMILAR PATTERNS OF AMINO ACIDS FOR 5WEO_D_CYZD1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		5 PRO A  27
SER A  87
GLY A  84
PRO A  77
MET A  72
 None
 1.39A 5weoA-1iybA:
0.5
5weoD-1iybA:
undetectable		 5weoA-1iybA:
11.55
5weoD-1iybA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE

(Methanopyrus
kandleri) 		PF01993
(MTD) 		5 ILE A  96
PRO A  75
SER A  17
GLY A  98
PRO A  80
 None
 1.27A 5weoA-1qv9A:
1.9
5weoD-1qv9A:
2.2		 5weoA-1qv9A:
14.39
5weoD-1qv9A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grk EVM001

(Ectromelia
virus) 		PF02250
(Orthopox_35kD) 		5 ILE A  24
PRO A  87
SER A 109
GLY A  23
SER A 116
 None
 1.42A 5weoA-2grkA:
0.0
5weoD-2grkA:
0.0		 5weoA-2grkA:
13.00
5weoD-2grkA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PRO A 687
SER A 527
GLY A 518
PRO A 551
ASP A 458
 None
 1.22A 5weoA-2vxoA:
3.0
5weoD-2vxoA:
2.4		 5weoA-2vxoA:
21.82
5weoD-2vxoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 ILE A 295
PRO A 309
SER A 279
GLY A 311
PRO A 203
 None
 1.48A 5weoA-3g05A:
0.0
5weoD-3g05A:
0.0		 5weoA-3g05A:
19.48
5weoD-3g05A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 ILE A  86
SER A  90
GLY A  87
SER A 225
ASP A 190
 None
LLP  A 226 ( 2.9A)
None
LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
 1.22A 5weoA-3getA:
0.9
5weoD-3getA:
4.0		 5weoA-3getA:
15.74
5weoD-3getA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 SER A  74
GLY A 164
PRO A  77
ASP A 298
LYS A 421
 None
 1.38A 5weoA-4ky0A:
0.3
5weoD-4ky0A:
0.3		 5weoA-4ky0A:
19.30
5weoD-4ky0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN

(Homo sapiens) 		PF00084
(Sushi)
PF00431
(CUB) 		5 ILE A 346
PRO A 347
GLY A 345
PRO A 358
SER A 365
 None
 1.12A 5weoA-4lotA:
undetectable
5weoD-4lotA:
undetectable		 5weoA-4lotA:
13.47
5weoD-4lotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ILE A 884
PRO A 933
SER A 952
GLY A 885
SER A1093
 None
 1.23A 5weoA-5a22A:
2.5
5weoD-5a22A:
0.6		 5weoA-5a22A:
19.58
5weoD-5a22A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 ILE A 285
PRO A 277
GLY A 281
MET A 306
ASP A 299
 ADP  A 401 (-4.2A)
None
None
None
None
 1.34A 5weoA-5eqtA:
undetectable
5weoD-5eqtA:
3.5		 5weoA-5eqtA:
13.83
5weoD-5eqtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ILE A2077
PRO A2076
SER A2054
GLY A2024
PRO A2020
 None
 1.15A 5weoA-5fbyA:
undetectable
5weoD-5fbyA:
3.7		 5weoA-5fbyA:
20.35
5weoD-5fbyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ILE A1928
PRO A1929
SER A1862
GLY A1927
PRO A1859
 None
 1.14A 5weoA-5i6gA:
undetectable
5weoD-5i6gA:
2.2		 5weoA-5i6gA:
22.03
5weoD-5i6gA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ILE A1928
PRO A1929
SER A1862
GLY A1927
PRO A1859
 None
 1.16A 5weoA-5i6hA:
2.3
5weoD-5i6hA:
undetectable		 5weoA-5i6hA:
21.26
5weoD-5i6hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ILE A1928
PRO A1929
SER A1862
GLY A1927
PRO A1859
 None
 1.29A 5weoA-5i6iA:
undetectable
5weoD-5i6iA:
undetectable		 5weoA-5i6iA:
19.12
5weoD-5i6iA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 PRO A 494
MET A 496
SER A 497
ASP A 760
LYS A 763
 None
 0.67A 5weoA-5welA:
54.3
5weoD-5welA:
54.3		 5weoA-5welA:
81.51
5weoD-5welA:
81.51