SIMILAR PATTERNS OF AMINO ACIDS FOR 5WEO_C_CYZC1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		5 PRO A  27
SER A  87
GLY A  84
PRO A  77
MET A  72
 None
 1.39A 5weoB-1iybA:
0.0
5weoC-1iybA:
0.1		 5weoB-1iybA:
11.55
5weoC-1iybA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PRO A 687
SER A 527
GLY A 518
PRO A 551
ASP A 458
 None
 1.19A 5weoB-2vxoA:
2.5
5weoC-2vxoA:
2.6		 5weoB-2vxoA:
21.82
5weoC-2vxoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 PRO A 246
SER A 236
SER A 386
GLY A 243
ASP A 438
 None
 1.36A 5weoB-4iv9A:
0.0
5weoC-4iv9A:
0.0		 5weoB-4iv9A:
20.34
5weoC-4iv9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 SER A  74
GLY A 164
PRO A  77
ASP A 298
LYS A 421
 None
 1.40A 5weoB-4ky0A:
0.2
5weoC-4ky0A:
0.9		 5weoB-4ky0A:
19.30
5weoC-4ky0A:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 PRO A 494
MET A 496
SER A 497
ASP A 760
LYS A 763
 None
 0.67A 5weoB-5welA:
54.3
5weoC-5welA:
35.0		 5weoB-5welA:
81.51
5weoC-5welA:
81.51