SIMILAR PATTERNS OF AMINO ACIDS FOR 5WEO_A_CYZA1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		5 PRO A  77
MET A  72
PRO A  27
SER A  87
GLY A  84
 None
 1.40A 5weoA-1iybA:
undetectable
5weoD-1iybA:
undetectable		 5weoA-1iybA:
11.55
5weoD-1iybA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 SER A  45
ILE A 225
SER A 220
SER A 208
GLY A 222
 FAD  A 800 (-3.3A)
None
None
None
None
 1.34A 5weoA-1knrA:
3.3
5weoD-1knrA:
3.3		 5weoA-1knrA:
19.01
5weoD-1knrA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 MET A 224
SER A 225
ILE A 200
SER A 187
GLY A 196
 None
 1.04A 5weoA-1kplA:
1.0
5weoD-1kplA:
undetectable		 5weoA-1kplA:
19.03
5weoD-1kplA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE

(Methanopyrus
kandleri) 		PF01993
(MTD) 		5 PRO A  80
ILE A  96
PRO A  75
SER A  17
GLY A  98
 None
 1.28A 5weoA-1qv9A:
2.0
5weoD-1qv9A:
2.2		 5weoA-1qv9A:
14.39
5weoD-1qv9A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 PRO A 181
SER A  55
ILE A  79
SER A  77
GLY A  78
 None
 1.45A 5weoA-1urtA:
undetectable
5weoD-1urtA:
undetectable		 5weoA-1urtA:
13.77
5weoD-1urtA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grk EVM001

(Ectromelia
virus) 		PF02250
(Orthopox_35kD) 		5 SER A 116
ILE A  24
PRO A  87
SER A 109
GLY A  23
 None
 1.42A 5weoA-2grkA:
undetectable
5weoD-2grkA:
0.0		 5weoA-2grkA:
13.00
5weoD-2grkA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kin KINESIN

(Rattus
norvegicus) 		PF00225
(Kinesin) 		5 PRO B 278
ILE B 266
SER B 260
SER B 258
GLY B 263
 None
 1.43A 5weoA-2kinB:
undetectable
5weoD-2kinB:
undetectable		 5weoA-2kinB:
6.92
5weoD-2kinB:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PRO A 551
ASP A 458
PRO A 687
SER A 527
GLY A 518
 None
 1.21A 5weoA-2vxoA:
2.9
5weoD-2vxoA:
2.5		 5weoA-2vxoA:
21.82
5weoD-2vxoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 SER X 164
ILE X  36
SER X  39
SER X  55
GLY X  40
 None
 1.44A 5weoA-2z22X:
4.0
5weoD-2z22X:
8.2		 5weoA-2z22X:
16.60
5weoD-2z22X:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 PRO A 203
ILE A 295
PRO A 309
SER A 279
GLY A 311
 None
 1.48A 5weoA-3g05A:
0.0
5weoD-3g05A:
0.0		 5weoA-3g05A:
19.48
5weoD-3g05A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 SER A 225
ASP A 190
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
None
LLP  A 226 ( 2.9A)
None
 1.21A 5weoA-3getA:
4.1
5weoD-3getA:
4.2		 5weoA-3getA:
15.74
5weoD-3getA:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 ILE A  92
PRO A 105
SER A 108
SER A 217
GLY A 219
 None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
None
 0.54A 5weoA-3h6tA:
8.2
5weoD-3h6tA:
7.2		 5weoA-3h6tA:
34.03
5weoD-3h6tA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 SER A 221
ILE A 235
PRO A 236
SER A 233
GLY A 234
 None
 1.35A 5weoA-4cgnA:
undetectable
5weoD-4cgnA:
undetectable		 5weoA-4cgnA:
16.55
5weoD-4cgnA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 ASP A 438
PRO A 246
SER A 236
SER A 386
GLY A 243
 None
 1.37A 5weoA-4iv9A:
2.7
5weoD-4iv9A:
2.6		 5weoA-4iv9A:
20.34
5weoD-4iv9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 PRO A  77
ASP A 298
LYS A 421
SER A  74
GLY A 164
 None
 1.37A 5weoA-4ky0A:
1.8
5weoD-4ky0A:
undetectable		 5weoA-4ky0A:
19.30
5weoD-4ky0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN

(Homo sapiens) 		PF00084
(Sushi)
PF00431
(CUB) 		5 PRO A 358
SER A 365
ILE A 346
PRO A 347
GLY A 345
 None
 1.12A 5weoA-4lotA:
undetectable
5weoD-4lotA:
undetectable		 5weoA-4lotA:
13.47
5weoD-4lotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 SER A1093
ILE A 884
PRO A 933
SER A 952
GLY A 885
 None
 1.23A 5weoA-5a22A:
2.5
5weoD-5a22A:
3.0		 5weoA-5a22A:
19.58
5weoD-5a22A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 MET A 306
ASP A 299
ILE A 285
PRO A 277
GLY A 281
 None
None
ADP  A 401 (-4.2A)
None
None
 1.34A 5weoA-5eqtA:
undetectable
5weoD-5eqtA:
3.5		 5weoA-5eqtA:
13.83
5weoD-5eqtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 PRO A2020
ILE A2077
PRO A2076
SER A2054
GLY A2024
 None
 1.15A 5weoA-5fbyA:
undetectable
5weoD-5fbyA:
3.8		 5weoA-5fbyA:
20.35
5weoD-5fbyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 5 SER A  89
ASP A 131
ILE A 204
SER A  14
GLY A 205
 None
 1.26A 5weoA-5fsbA:
undetectable
5weoD-5fsbA:
undetectable		 5weoA-5fsbA:
12.57
5weoD-5fsbA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 PRO A1859
ILE A1928
PRO A1929
SER A1862
GLY A1927
 None
 1.15A 5weoA-5i6gA:
undetectable
5weoD-5i6gA:
2.1		 5weoA-5i6gA:
22.03
5weoD-5i6gA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 PRO A1859
ILE A1928
PRO A1929
SER A1862
GLY A1927
 None
 1.17A 5weoA-5i6hA:
2.3
5weoD-5i6hA:
undetectable		 5weoA-5i6hA:
21.26
5weoD-5i6hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 PRO A1859
ILE A1928
PRO A1929
SER A1862
GLY A1927
 None
 1.30A 5weoA-5i6iA:
undetectable
5weoD-5i6iA:
undetectable		 5weoA-5i6iA:
19.12
5weoD-5i6iA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 PRO B 192
ILE B 194
SER B 369
SER B 237
GLY B 241
 None
 1.46A 5weoA-5n8nB:
undetectable
5weoD-5n8nB:
5.0		 5weoA-5n8nB:
5.86
5weoD-5n8nB:
5.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 ILE A 481
PRO A 494
SER A 497
SER A 729
GLY A 731
 None
 0.44A 5weoA-5welA:
54.3
5weoD-5welA:
54.3		 5weoA-5welA:
81.51
5weoD-5welA:
81.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 PRO A 494
MET A 496
SER A 497
ASP A 760
LYS A 763
 None
 0.65A 5weoA-5welA:
54.3
5weoD-5welA:
54.3		 5weoA-5welA:
81.51
5weoD-5welA:
81.51