SIMILAR PATTERNS OF AMINO ACIDS FOR 5WEA_A_IPHA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a79 TRNA ENDONUCLEASE

(Methanocaldococcus
jannaschii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		4 LEU A  51
TYR A  77
LEU A  85
GLU A  82
 None
 1.33A 5weaA-1a79A:
undetectable		 5weaA-1a79A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad9 IGG CTM01 FAB (LIGHT
CHAIN)

(Homo sapiens) 		no annotation 4 LEU L  27
LYS L  27
LEU L  92
GLU L  93
 None
 1.18A 5weaA-1ad9L:
undetectable		 5weaA-1ad9L:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7f PROTEIN (SXL-LETHAL
PROTEIN)

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		4 LEU A 196
TYR A 131
LYS A 194
LEU A 132
 None
U  P   6 ( 3.7A)
U  P   7 ( 3.8A)
None
 1.34A 5weaA-1b7fA:
3.2		 5weaA-1b7fA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 LEU A 122
TYR A 120
LEU A   4
GLU A  13
 None
 1.32A 5weaA-1bqcA:
undetectable		 5weaA-1bqcA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 LEU A 164
LYS A 168
LEU A 231
GLU A 134
 None
 1.24A 5weaA-1bxtA:
undetectable		 5weaA-1bxtA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		4 LEU A 335
LYS A 331
LEU A 290
GLU A 296
 None
GDP  A 432 (-3.0A)
None
None
 1.27A 5weaA-1cg4A:
1.7		 5weaA-1cg4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cun PROTEIN (ALPHA
SPECTRIN)

(Gallus gallus) 		PF00435
(Spectrin) 		4 LEU A  97
LYS A  25
LEU A  55
GLU A  54
 None
 0.99A 5weaA-1cunA:
undetectable		 5weaA-1cunA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU A 137
TYR A 328
LEU A  11
GLU A   7
 None
 1.34A 5weaA-1d6mA:
3.2		 5weaA-1d6mA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 LEU A1110
TYR A1113
LEU A1083
GLU A1080
 None
 1.23A 5weaA-1e69A:
undetectable		 5weaA-1e69A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR B 545
LYS B 544
LEU B 667
GLU B 671
 None
 1.18A 5weaA-1gl9B:
4.8		 5weaA-1gl9B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 207
LYS A 322
LEU A 310
GLU A 309
 None
 1.33A 5weaA-1gsoA:
4.2		 5weaA-1gsoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 LEU A 635
LYS A 632
LEU A 586
GLU A 589
 None
 1.26A 5weaA-1gxkA:
undetectable		 5weaA-1gxkA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hml ALPHA-LACTALBUMIN

(Homo sapiens) 		PF00062
(Lys) 		4 LEU A  52
LYS A   1
LEU A   8
GLU A   7
 None
 1.21A 5weaA-1hmlA:
undetectable		 5weaA-1hmlA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		4 LEU A 249
LYS A 358
LEU A 282
GLU A 279
 HEM  A 410 ( 4.3A)
None
None
None
 0.96A 5weaA-1jioA:
undetectable		 5weaA-1jioA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 336
LYS A 345
LEU A  71
GLU A  70
 None
 1.31A 5weaA-1m0wA:
undetectable		 5weaA-1m0wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		4 LEU A 367
LYS A 363
LEU A 322
GLU A 328
 None
 1.26A 5weaA-1mf1A:
undetectable		 5weaA-1mf1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.15A 5weaA-1p9bA:
undetectable		 5weaA-1p9bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		4 LEU A 139
LYS A 501
LEU A 418
GLU A 415
 None
ADP  A1528 ( 4.3A)
None
None
 1.20A 5weaA-1q3sA:
2.8		 5weaA-1q3sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF13177
(DNA_pol3_delta2) 		4 LEU E 202
TYR E   8
LEU E 237
GLU E 238
 None
 1.31A 5weaA-1sxjE:
2.8		 5weaA-1sxjE:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t06 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		4 LEU A 175
LYS A 157
LEU A 153
GLU A 154
 None
 1.27A 5weaA-1t06A:
undetectable		 5weaA-1t06A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 LEU A 159
LYS A   6
LEU A  23
GLU A  27
 None
 1.22A 5weaA-1t9kA:
undetectable		 5weaA-1t9kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 4 LEU A 348
LYS A  45
LEU A 150
GLU A 151
 HEM  A 999 ( 4.5A)
None
HEM  A 999 ( 4.3A)
None
 0.86A 5weaA-1u5uA:
undetectable		 5weaA-1u5uA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  82
LYS A 147
LEU A 150
GLU A 194
 None
 1.19A 5weaA-1ukwA:
undetectable		 5weaA-1ukwA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyn CALPONIN-2

(Homo sapiens) 		PF00307
(CH) 		4 LEU A 113
TYR A  14
LEU A  22
GLU A  19
 None
 1.34A 5weaA-1wynA:
undetectable		 5weaA-1wynA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6z HEAT SHOCK PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00183
(HSP90) 		4 LEU A 244
TYR A 252
LYS A 250
LEU A 188
 None
 1.02A 5weaA-1y6zA:
undetectable		 5weaA-1y6zA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		4 LEU A  23
LYS A 231
LEU A 224
GLU A 225
 None
 1.14A 5weaA-1zzgA:
3.9		 5weaA-1zzgA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9h VOLTAGE-GATED
POTASSIUM CHANNEL

(Streptomyces
lividans) 		PF07885
(Ion_trans_2) 		4 LEU A  81
TYR A  82
LEU A  59
GLU A  51
 None
 1.29A 5weaA-2a9hA:
undetectable		 5weaA-2a9hA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czt PROSTAGLANDIN-H2
D-ISOMERASE

(Mus musculus) 		PF00061
(Lipocalin) 		4 LEU A 148
LYS A 162
LEU A 130
GLU A 122
 None
 1.28A 5weaA-2cztA:
undetectable		 5weaA-2cztA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 LEU A 107
LYS A  51
LEU A  47
GLU A  48
 None
 1.25A 5weaA-2d58A:
undetectable		 5weaA-2d58A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eql HORSE MILK LYSOZYME

(Equus caballus) 		PF00062
(Lys) 		4 LEU A  56
LYS A   1
LEU A   8
GLU A   7
 None
 1.26A 5weaA-2eqlA:
undetectable		 5weaA-2eqlA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 205
LYS A 202
LEU A 166
GLU A 163
 None
 1.34A 5weaA-2hpiA:
2.9		 5weaA-2hpiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 LEU A 307
LYS A 240
LEU A 279
GLU A 282
 None
 1.15A 5weaA-2iu4A:
3.4		 5weaA-2iu4A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsp TRANSCRIPTIONAL
REGULATORY PROTEIN
ROS

(Agrobacterium
tumefaciens) 		PF05443
(ROS_MUCR) 		4 LEU A  55
LYS A  52
LEU A  25
GLU A  26
 None
 1.33A 5weaA-2jspA:
undetectable		 5weaA-2jspA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 LEU A 229
LYS A 280
LEU A 245
GLU A 248
 None
 1.17A 5weaA-2nuxA:
2.2		 5weaA-2nuxA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptt CD48 ANTIGEN

(Mus musculus) 		PF07686
(V-set) 		4 LEU A  43
LYS A  51
LEU A  64
GLU A  66
 None
 1.18A 5weaA-2pttA:
undetectable		 5weaA-2pttA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0z PROTEIN PRO2281

(Homo sapiens) 		PF02889
(Sec63) 		4 LEU X  64
LYS X  83
LEU X  60
GLU X  57
 None
 1.35A 5weaA-2q0zX:
undetectable		 5weaA-2q0zX:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 LEU A 514
TYR A 601
LYS A 516
GLU A 512
 None
 1.33A 5weaA-2quqA:
undetectable		 5weaA-2quqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6i UNCHARACTERIZED
PROTEIN ATU1473

(Agrobacterium
fabrum) 		PF07542
(ATP12) 		4 LEU A 180
LYS A 182
LEU A 206
GLU A 210
 None
 1.33A 5weaA-2r6iA:
undetectable		 5weaA-2r6iA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		4 LEU A 366
LYS A 362
LEU A 321
GLU A 327
 None
GDP  A1457 (-3.0A)
None
None
 1.31A 5weaA-2v40A:
undetectable		 5weaA-2v40A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwx DRRA

(Legionella
pneumophila) 		no annotation 4 LEU B 389
LYS B 350
LEU B 346
GLU B 347
 None
 1.33A 5weaA-2wwxB:
undetectable		 5weaA-2wwxB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		4 LEU A  78
TYR A 219
LEU A  99
GLU A  96
 None
 1.32A 5weaA-2x66A:
undetectable		 5weaA-2x66A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		4 LEU A 147
TYR A 113
LYS A 115
GLU A 172
 None
None
CIT  A1249 (-2.7A)
None
 0.84A 5weaA-2xu2A:
2.2		 5weaA-2xu2A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xv9 ABA-1A1 REPEAT UNIT

(Ascaris suum) 		PF16469
(NPA) 		4 LEU A  37
LYS A  28
LEU A   5
GLU A   6
 None
 1.19A 5weaA-2xv9A:
undetectable		 5weaA-2xv9A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		4 LEU B 127
LYS B 490
LEU B 407
GLU B 404
 None
 1.08A 5weaA-3aq1B:
2.0		 5weaA-3aq1B:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 348
LYS A  45
LEU A 150
GLU A 151
 HEM  A1100 ( 4.5A)
None
None
None
 0.83A 5weaA-3dy5A:
undetectable		 5weaA-3dy5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4

(Rattus
norvegicus) 		PF13848
(Thioredoxin_6) 		4 LEU A 394
LYS A 441
LEU A 437
GLU A 438
 None
 1.25A 5weaA-3ec3A:
undetectable		 5weaA-3ec3A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		4 LEU A 336
LYS A 332
LEU A 291
GLU A 297
 None
 1.26A 5weaA-3hidA:
undetectable		 5weaA-3hidA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 1.20A 5weaA-3i23A:
4.3		 5weaA-3i23A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2

(Thermus
thermophilus) 		PF01257
(2Fe-2S_thioredx) 		4 LEU 2  11
LYS 2   3
LEU 2  52
GLU 2  48
 None
 1.26A 5weaA-3i9v2:
undetectable		 5weaA-3i9v2:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iey TRNA-SPLICING
ENDONUCLEASE

(Nanoarchaeum
equitans) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		4 LEU A  17
TYR A  24
LEU A  31
GLU A  30
 None
 1.27A 5weaA-3ieyA:
undetectable		 5weaA-3ieyA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 LEU K 455
TYR K 487
LEU K 398
GLU K 399
 None
 1.23A 5weaA-3jblK:
2.1		 5weaA-3jblK:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k60 HEAT SHOCK PROTEIN
86

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A  75
TYR A 184
LEU A 185
GLU A 186
 None
 1.30A 5weaA-3k60A:
undetectable		 5weaA-3k60A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		4 LEU A  48
TYR A 276
LEU A 299
GLU A 298
 None
 1.01A 5weaA-3licA:
undetectable		 5weaA-3licA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 207
LYS A 322
LEU A 310
GLU A 309
 None
 1.29A 5weaA-3mjfA:
3.8		 5weaA-3mjfA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myd FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Helicobacter
pylori) 		PF00771
(FHIPEP) 		4 LEU A 657
LYS A 647
LEU A 659
GLU A 663
 None
 1.26A 5weaA-3mydA:
undetectable		 5weaA-3mydA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		4 LEU A 104
TYR A 106
LEU A 113
GLU A 112
 None
UNL  A 288 ( 4.4A)
None
None
 1.35A 5weaA-3nrbA:
3.0		 5weaA-3nrbA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 TYR A 542
LYS A 627
LEU A 538
GLU A 539
 None
 1.27A 5weaA-3q9oA:
undetectable		 5weaA-3q9oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnl SULFOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF13469
(Sulfotransfer_3) 		4 LEU A 155
TYR A 152
LEU A 127
GLU A 133
 GOL  A 313 (-3.9A)
None
None
None
 1.32A 5weaA-3rnlA:
3.9		 5weaA-3rnlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9j F-BOX/LRR-REPEAT
PROTEIN 5

(Homo sapiens) 		PF01814
(Hemerythrin) 		4 LEU A  44
TYR A  48
LEU A  96
GLU A  93
 None
 1.30A 5weaA-3u9jA:
undetectable		 5weaA-3u9jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		4 LEU A 353
LYS A 349
LEU A 308
GLU A 314
 None
 1.22A 5weaA-3ue9A:
1.7		 5weaA-3ue9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 LEU A 409
TYR A 408
LYS A 407
GLU A 244
 None
 1.31A 5weaA-3uowA:
3.0		 5weaA-3uowA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 409
TYR A 407
LYS A 343
LEU A 560
 None
 1.23A 5weaA-3v4oA:
3.6		 5weaA-3v4oA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 TYR A 198
LYS A 197
LEU A 133
GLU A 194
 None
 1.26A 5weaA-3vohA:
undetectable		 5weaA-3vohA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 286
LYS A 263
LEU A 276
GLU A 273
 None
 1.33A 5weaA-3vthA:
2.8		 5weaA-3vthA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x29 CLAUDIN-19
HEAT-LABILE
ENTEROTOXIN B CHAIN

(Mus musculus;
Clostridium
perfringens) 		PF00822
(PMP22_Claudin)
PF03505
(Clenterotox) 		4 LEU B 223
TYR B 224
LEU A  46
GLU A  48
 None
 1.20A 5weaA-3x29B:
undetectable		 5weaA-3x29B:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ack TSSL

(Francisella
tularensis) 		PF09850
(DotU) 		4 LEU A  50
TYR A  53
LYS A  52
GLU A   6
 None
 1.32A 5weaA-4ackA:
undetectable		 5weaA-4ackA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 409
TYR A 407
LYS A 343
LEU A 560
 None
 1.22A 5weaA-4i1pA:
3.0		 5weaA-4i1pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		4 LEU A 270
LYS A 262
LEU A 301
GLU A 305
 None
 1.30A 5weaA-4ijrA:
undetectable		 5weaA-4ijrA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus) 		PF03051
(Peptidase_C1_2) 		4 LEU A 187
LYS A 204
LEU A 116
GLU A 113
 None
 1.26A 5weaA-4k7cA:
undetectable		 5weaA-4k7cA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkb HYPOTHETICAL PROTEIN
ALR4568/PUTATIVE
4-OXALOCROTONATE
TAUTOMERASE

(Nostoc sp. PCC
7120) 		no annotation 4 LEU F  81
LYS F  77
LEU F 103
GLU F 105
 None
 1.29A 5weaA-4lkbF:
undetectable		 5weaA-4lkbF:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx1 PUTATIVE RRNA
METHYLTRANSFERASE

(Sorangium
cellulosum) 		no annotation 4 LEU A  81
LYS A   1
LEU A  17
GLU A  93
 None
 1.15A 5weaA-4rx1A:
2.5		 5weaA-4rx1A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 LEU A 544
LYS A 531
LEU A 120
GLU A 124
 None
 1.16A 5weaA-4s28A:
2.9		 5weaA-4s28A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3q 17 KDA LIPOPROTEIN

(Treponema
pallidum) 		PF04170
(NlpE) 		4 TYR A  67
LYS A  51
LEU A  81
GLU A  96
 None
 1.26A 5weaA-4u3qA:
undetectable		 5weaA-4u3qA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE

(Pyrococcus sp.
ST04) 		PF13419
(HAD_2) 		4 LEU A 195
TYR A 197
LEU A 216
GLU A 215
 None
 1.24A 5weaA-4uw9A:
4.4		 5weaA-4uw9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		4 LEU A 443
TYR A 441
LEU A 412
GLU A 413
 None
 1.22A 5weaA-4woyA:
2.1		 5weaA-4woyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x7m TARM

(Staphylococcus
aureus) 		PF00534
(Glycos_transf_1) 		4 LEU A  54
LYS A  15
LEU A  11
GLU A  10
 None
 1.32A 5weaA-4x7mA:
4.8		 5weaA-4x7mA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xci THERMOSOME SUBUNIT
ALPHA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		4 LEU A 135
LYS A 507
LEU A 423
GLU A 420
 None
 1.09A 5weaA-4xciA:
undetectable		 5weaA-4xciA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 LEU A 367
LYS A 361
LEU A 279
GLU A 282
 None
 1.06A 5weaA-4zr5A:
undetectable		 5weaA-4zr5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 LEU A 505
LYS A 450
LEU A 217
GLU A 218
 None
 1.06A 5weaA-5a2rA:
undetectable		 5weaA-5a2rA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2

(Saccharomyces
cerevisiae) 		PF07651
(ANTH) 		4 TYR F 228
LYS F 225
LEU F 230
GLU F 229
 None
 1.33A 5weaA-5ahvF:
undetectable		 5weaA-5ahvF:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT C-3

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		4 LEU B 142
TYR A  97
LEU B 108
GLU B 107
 None
 1.35A 5weaA-5g49B:
undetectable		 5weaA-5g49B:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N) 		4 LEU B1004
LYS B 999
LEU A 195
GLU A 199
 None
 1.03A 5weaA-5h67B:
undetectable		 5weaA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 LEU A 340
LYS A 336
LEU A 295
GLU A 301
 None
 1.29A 5weaA-5i33A:
undetectable		 5weaA-5i33A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 LEU A 492
TYR A 403
LYS A 460
GLU A 426
 None
 1.19A 5weaA-5imyA:
undetectable		 5weaA-5imyA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A 115
LYS A 127
LEU A 119
GLU A 124
 None
 1.33A 5weaA-5iwwA:
2.9		 5weaA-5iwwA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 LEU A 211
TYR A 254
LEU A 216
GLU A 217
 None
 1.33A 5weaA-5l51A:
2.2		 5weaA-5l51A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A  12
TYR A  19
LYS A  15
GLU A  53
 None
 1.33A 5weaA-5macA:
undetectable		 5weaA-5macA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 LEU A  60
LYS A 262
LEU A  56
GLU A  53
 None
 1.34A 5weaA-5svcA:
undetectable		 5weaA-5svcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf3 PUTATIVE MEMBRANE
PROTEIN

(Yersinia pestis) 		PF06711
(DUF1198) 		4 LEU A  75
TYR A  74
LYS A  71
GLU A 110
 None
 0.92A 5weaA-5tf3A:
undetectable		 5weaA-5tf3A:
10.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 LEU A 651
LYS A 661
LEU A 695
GLU A 696
 None
 1.01A 5weaA-5vm9A:
55.7		 5weaA-5vm9A:
79.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 LEU A 651
TYR A 655
LEU A 695
GLU A 696
 None
 0.80A 5weaA-5vm9A:
55.7		 5weaA-5vm9A:
79.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU J 354
TYR J 361
LEU J 253
GLU J 240
 None
None
None
A  M  17 ( 4.0A)
 1.22A 5weaA-5vzjJ:
undetectable		 5weaA-5vzjJ:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 LEU A 650
TYR A 654
LYS A 660
LEU A 694
GLU A 695
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
 0.00A 5weaA-5weaA:
68.4		 5weaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whg PROTEIN VMS1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 210
TYR A 190
LEU A 389
GLU A 388
 None
 1.28A 5weaA-5whgA:
undetectable		 5weaA-5whgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 4 LEU A  94
TYR A 130
LEU A 102
GLU A 106
 None
 1.23A 5weaA-6cv9A:
undetectable		 5weaA-6cv9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdt -

(-) 		no annotation 4 TYR A 349
LYS A 351
LEU A 379
GLU A 380
 None
 1.17A 5weaA-6fdtA:
undetectable		 5weaA-6fdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 352
TYR A 460
LEU A 388
GLU A 392
 None
 1.30A 5weaA-6fyoA:
undetectable		 5weaA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 352
TYR A 460
LEU A 388
GLU A 392
 None
 1.33A 5weaA-6fyvA:
undetectable		 5weaA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdr -

(-) 		no annotation 4 LEU A 190
TYR A  17
LEU A 179
GLU A 176
 None
 1.33A 5weaA-6gdrA:
undetectable		 5weaA-6gdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gxz -

(-) 		no annotation 4 TYR A 349
LYS A 351
LEU A 379
GLU A 380
 None
 1.17A 5weaA-6gxzA:
undetectable		 5weaA-6gxzA:
undetectable